<PAGE>
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549
------------
SCHEDULE 13D
(RULE 13d-101)
INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO 13d-1(a)
AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2(a)
(AMENDMENT NO. __)(1)
GUILFORD PHARMACEUTICALS INC.
-----------------------------
(Name of Issuer)
COMMON STOCK
------------
(Title of Class of Securities)
401829 10 6
-----------
(CUSIP Number)
Marc Schneidman
BVF Partners L.P.
333 West Wacker Drive, Suite 1600
Chicago, Illinois 60606
(415) 288-2396
-----------------------------------------
(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)
September 8, 1998
-----------------
(Date of Event which Requires Filing of this Statement)
If the filing person has previously filed a statement on Schedule 13G to
report the acquisition which is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(b)(3) or (4), check the following box / /.
NOTE: Six copies of this statement, including all exhibits, should be filed
with the Commission. SEE Rule 13d-1(a) for other parties to whom copies are to
be sent.
(Continued on following pages)
(Page 1 of 8 Pages)
---------------------
(1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, SEE the
NOTES).
<PAGE>
- -------------------------------- ------------------------------------
CUSIP NO. 401829 10 6 13D Page 2 of 8 Pages
- -------------------------------- ------------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
BIOTECHNOLOGY VALUE FUND, L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) /X/ (b) / /
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 SOURCE OF FUNDS*
WC
- --------------------------------------------------------------------------------
5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) / /
- --------------------------------------------------------------------------------
6 CITIZENSHIP OR PLACE OF ORGANIZATION
DELAWARE
- --------------------------------------------------------------------------------
NUMBER 7 SOLE VOTING POWER
OF -0-
SHARES --------------------------------------------
BENEFICIALLY 8 SHARED VOTING POWER
OWNED BY EACH 574,547
REPORTING --------------------------------------------
PERSON 9 SOLE DISPOSITIVE POWER
WITH -0-
--------------------------------------------
10 SHARED DISPOSITIVE POWER
574,547
- --------------------------------------------------------------------------------
11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON
574,547
- --------------------------------------------------------------------------------
12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
CERTAIN SHARES* / /
- --------------------------------------------------------------------------------
13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
3.0%
- --------------------------------------------------------------------------------
14 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- -------------------------------- ------------------------------------
CUSIP NO. 401829 10 6 13D Page 3 of 8 Pages
- -------------------------------- ------------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
BVF PARTNERS L.P.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) /X/ (b) / /
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 SOURCE OF FUNDS*
OO
- --------------------------------------------------------------------------------
5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) / /
- --------------------------------------------------------------------------------
6 CITIZENSHIP OR PLACE OF ORGANIZATION
DELAWARE
- --------------------------------------------------------------------------------
NUMBER 7 SOLE VOTING POWER
OF -0-
SHARES --------------------------------------------
BENEFICIALLY 8 SHARED VOTING POWER
OWNED BY EACH 1,252,774
REPORTING --------------------------------------------
PERSON 9 SOLE DISPOSITIVE POWER
WITH -0-
--------------------------------------------
10 SHARED DISPOSITIVE POWER
1,252,774
- --------------------------------------------------------------------------------
11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON
1,252,774
- --------------------------------------------------------------------------------
12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
CERTAIN SHARES* / /
- --------------------------------------------------------------------------------
13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
6.4%
- --------------------------------------------------------------------------------
14 TYPE OF REPORTING PERSON*
PN
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- -------------------------------- ------------------------------------
CUSIP NO. 401829 10 6 13D Page 4 of 8 Pages
- -------------------------------- ------------------------------------
- --------------------------------------------------------------------------------
1 NAME OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
BVF INC.
- --------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
(a) /X/ (b) / /
- --------------------------------------------------------------------------------
3 SEC USE ONLY
- --------------------------------------------------------------------------------
4 SOURCE OF FUNDS*
WC, OO
- --------------------------------------------------------------------------------
5 CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS
REQUIRED PURSUANT TO ITEMS 2(d) OR 2(e) / /
- --------------------------------------------------------------------------------
6 CITIZENSHIP OR PLACE OF ORGANIZATION
DELAWARE
- --------------------------------------------------------------------------------
NUMBER 7 SOLE VOTING POWER
OF -0-
SHARES --------------------------------------------
BENEFICIALLY 8 SHARED VOTING POWER
OWNED BY EACH 1,252,774
REPORTING --------------------------------------------
PERSON 9 SOLE DISPOSITIVE POWER
WITH -0-
--------------------------------------------
10 SHARED DISPOSITIVE POWER
1,252,774
- --------------------------------------------------------------------------------
11 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
REPORTING PERSON
1,252,774
- --------------------------------------------------------------------------------
12 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
CERTAIN SHARES* / /
- --------------------------------------------------------------------------------
13 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
6.4%
- --------------------------------------------------------------------------------
14 TYPE OF REPORTING PERSON*
IA, CO
- --------------------------------------------------------------------------------
* SEE INSTRUCTIONS BEFORE FILLING OUT!
<PAGE>
- -------------------------------- ------------------------------------
CUSIP NO. 401829 10 6 13D Page 5 of 8 Pages
- -------------------------------- ------------------------------------
ITEM 1. SECURITY AND ISSUER.
This Statement on Schedule 13D (this "Statement") relates to the Common
Stock, par value $0.01 per share (the "Stock"), of Guilford Pharmaceuticals
Inc., a Delaware corporation ("Guilford"). The principal executive office of
Guilford is located at 6611 Tributary Street, Baltimore, Maryland 21224.
ITEM 2. IDENTITY AND BACKGROUND.
The persons filing this Statement, the persons enumerated in Instruction C
of Schedule 13D and, where applicable, their respective places of organization,
general partners, directors, executive officers and controlling persons, and
certain information regarding each of them, are as follows:
(a) Biotechnology Value Fund, L.P., a Delaware limited partnership
("BVF"), BVF Partners L.P., a Delaware limited partnership ("Partners"), BVF
Inc., a Delaware corporation ("BVF Inc."), and Mark N. Lampert, an individual
("Lampert") (collectively, the "Reporting Persons").
(b) The business address of BVF and Partners is 333 West Wacker Drive,
Suite 1600, Chicago, Illinois 60606. The business address of BVF Inc. and
Lampert is One Sansome Street, 39th Floor, San Francisco, California 94104.
(c) Partners is the general partner of BVF, which is an investment
limited partnership. BVF Inc. is an investment adviser to and general partner
of Partners. Lampert is the sole shareholder, sole director and an officer of
BVF Inc.
(d) During the last five years, none of such persons has been convicted
in a criminal proceeding (excluding traffic violations and similar
misdemeanors).
(e) During the last five years, none of such persons was a party to a
civil proceeding of a judicial or administrative body of competent jurisdiction
and as a result of such proceeding was or is subject to a judgment, decree or
final order enjoining future violations of, or prohibiting or mandating
activities subject to, federal or state securities laws or finding any violation
with respect to such laws.
(f) Lampert is a citizen of the United States of America.
<PAGE>
- -------------------------------- ------------------------------------
CUSIP NO. 401829 10 6 13D Page 6 of 8 Pages
- -------------------------------- ------------------------------------
ITEM 3. SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.
Since July 6, 1998, Partners, in its capacity as general partner of BVF,
has purchased on behalf of such limited partnership an aggregate number of
363,280 shares of the Stock for an aggregate consideration of $5,953,193.56,
utilizing funds provided by BVF from its working capital pursuant to the terms
of its limited partnership agreement with Partners. In addition, Partners, in
its capacity as investment manager with respect to certain managed accounts, has
purchased on behalf of such managed accounts an aggregate number of 456,420
shares of the Stock for an aggregate consideration of $8,544,946.18, utilizing
funds under management by Partners pursuant to investment management agreements
between Partners and such managed accounts.
ITEM 4. PURPOSE OF TRANSACTIONS.
The external environment for small, quality biotechnology companies is
undergoing a period of rapid and profound change. The convergence of a
depressed equity market, the possible slowing pace of a corporate partnering
activity, and escalating cash burn rates could produce an industry shake-out in
which financially conservative companies prosper and financially weak companies
falter. This changing environment may call for managements and Boards to
husband capital by significantly reducing cash burn rates and to otherwise alter
preconceived business plans. If managed pro-actively and intelligently, this
period could yield attractive returns for shareholders. However, the
consequences of complacency and the potential for irreparable missteps are
great. BVF may seek to work with company managements, Boards and shareholders
to maximize shareholder value and, specifically, to protect the substantial
value of funded, partnered programs from unnecessary dilution. BVF IS AMENDING
ALL ITS 13-D FILINGS WITH THIS NOTICE.
ITEM 5. INTEREST IN SECURITIES OF THE ISSUER.
(a) BVF beneficially owns 574,547 shares of the Stock, Partners
beneficially owns 1,252,774 shares of the Stock, and BVF Inc. beneficially owns
1,252,774 shares of the Stock, approximately 3.0%, 6.4% and 6.4%, respectively,
of the aggregate number of shares outstanding as of August 10, 1998 (as reported
in Guilford's most recent quarterly statement on Form 10-Q).
(b) BVF shares voting and dispositive power over the 574,547 shares of
the Stock it beneficially owns with Partners. Partners and BVF Inc. share
voting and dispositive power over the 1,252,774 shares of the Stock they
beneficially own with, in addition to BVF, the managed accounts on whose behalf
Partners, as investment manager, purchased such shares. The managed accounts on
whose behalf Partners owns shares of the Stock are Investment 10 L.L.C., an
Illinois limited liability company ("ILL10"), Palamundo, L.D.C., a limited
duration company organized under the laws of the Cayman Islands ("Palamundo"),
ZPG Securities, L.L.C., a New York limited liability company ("ZPG") and
Biotechnology Value
<PAGE>
- -------------------------------- ------------------------------------
CUSIP NO. 401829 10 6 13D Page 7 of 8 Pages
- -------------------------------- ------------------------------------
Fund, Ltd., a Cayman Islands Corporation ("BVF Ltd."). ILL10, Palamundo, ZPG
and BVF Ltd. are collectively referred to herein as the "Accounts." The
Accounts specialize in holding biotechnology stocks for investment purposes and
the business address of each is c/o BVF Partners L.P., 333 West Wacker Drive,
Suite 1600, Chicago, Illinois 60606.
(c) Exhibit B attached hereto contains information as to all
transactions in the Stock by the Reporting Persons during the past 60 days. All
such transactions were made for cash in open market, over-the-counter
transactions. No other transactions in the Stock have been effected by the
Reporting Persons during the past 60 days.
(d) The Accounts are entitled to receive dividends and any sale proceeds
with respect to the Stock in proportion to their respective ownership interests
therein.
ITEM 6. CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH
RESPECT TO SECURITIES OF THE ISSUER.
Partners is the general partner of BVF pursuant to a limited partnership
agreement which authorizes Partners, among other things, to invest the funds of
BVF in the Stock and to vote and dispose of the Stock. Pursuant to such limited
partnership agreement, Partners is entitled to allocations based on assets under
management and realized and unrealized gains thereon. Pursuant to investment
management agreements with the Accounts, Partners and BVF Inc. have the
authority, among other things, to invest funds of the Accounts in the Stock and
to vote and dispose of the Stock. Pursuant to such agreements, Partners and BVF
Inc. receive fees based on assets under management and realized and unrealized
gains thereon. BVF Inc. is the general partner of Partners and may be deemed to
own beneficially securities over which Partners exercises voting and dispositive
power.
ITEM 7. MATERIAL TO BE FILED AS EXHIBITS.
Exhibit A - Agreement Regarding Joint Filing
Exhibit B - Transactions in the Stock by the Reporting Persons during the
past 60 days.
<PAGE>
- -------------------------------- ------------------------------------
CUSIP NO. 401829 10 6 13D Page 8 of 8 Pages
- -------------------------------- ------------------------------------
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Dated: September 8, 1998
BIOTECHNOLOGY VALUE FUND, L.P.
By: BVF Partners L.P., its general partner
By: BVF Inc., its general partner
By: /s/ MARK N. LAMPERT
------------------------------
Mark N. Lampert
President
BVF PARTNERS L.P.
By: BVF Inc., its general partner
By: /s/ MARK N. LAMPERT
----------------------------------
Mark N. Lampert
President
BVF INC.
By: /s/ MARK N. LAMPERT
----------------------------------------
Mark N. Lampert
President
<PAGE>
EXHIBIT A
AGREEMENT REGARDING JOINT FILING
The undersigned, Biotechnology Value Fund, L.P., a Delaware limited
partnership, and BVF Partners L.P., a Delaware limited partnership, and BVF
Inc., a Delaware corporation, hereby agree and acknowledge that the statement
containing the information required by Schedule 13D, to which this Agreement is
attached as an exhibit, is filed on behalf of each of them. The undersigned
further agree that any amendments or supplements thereto shall also be filed on
behalf of each of them.
Dated: September 8, 1998
BIOTECHNOLOGY VALUE FUND, L.P.
By: BVF Partners L.P., its general partner
By: BVF Inc., its general partner
By: /s/ MARK N. LAMPERT
-----------------------------
Mark N. Lampert
President
BVF PARTNERS L.P.
By: BVF Inc., its general partner
By: /s/ MARK N. LAMPERT
---------------------------------
Mark N. Lampert
President
BVF INC.
By: /s/ MARK N. LAMPERT
---------------------------------------
Mark N. Lampert
President
<PAGE>
EXHIBIT B
TRANSACTIONS IN THE STOCK BY THE REPORTING PERSONS
DURING THE PAST 60 DAYS
<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------------------
SETTLEMENT FOR THE PRICE PER
DATE BY ACCOUNT OF QUANTITY SHARE TYPE OF TRADE BROKER
- -------------------------------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C>
07/07/98 Partners BVF 7,000 $17.2500 Purchase BTAB
- -------------------------------------------------------------------------------------------------------------
07/07/98 Partners ILL10 2,000 $17.2500 Purchase BTAB
- -------------------------------------------------------------------------------------------------------------
07/07/98 Partners PAL 2,000 $17.2500 Purchase BTAB
- -------------------------------------------------------------------------------------------------------------
07/07/98 Partners ZPG 1,000 $17.2500 Purchase BTAB
- -------------------------------------------------------------------------------------------------------------
07/07/98 Partners BVF Ltd. 11,000 $17.2500 Purchase BTAB
- -------------------------------------------------------------------------------------------------------------
07/07/98 Partners BVF 600 $17.6250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/0898 Partners BVF 5,000 $17.2500 Purchase BTAB
- -------------------------------------------------------------------------------------------------------------
07/08/98 Partners BVF Ltd. 15,000 $17.2500 Purchase BTAB
- -------------------------------------------------------------------------------------------------------------
07/09/98 Partners BVF 7,000 $17.1966 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/09/98 Partners BVF Ltd. 5,000 $17.1250 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
07/09/98 Partners BVF Ltd. 7,100 $17.1986 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/10/98 Partners BVF Ltd. 600 $17.2500 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/13/98 Partners BVF 3,200 $16.7171 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/13/98 Partners ILL10 2,000 $16.7171 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/13/98 Partners PAL 2,000 $16.7171 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/13/98 Partners BVF Ltd. 10,000 $16.7171 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/13/98 Partner BVF Ltd. 4,000 $16.8750 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/14/98 Partners BVF 4,000 $16.6250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/14/98 Partners BVF Ltd. 4,400 $16.6250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/16/98 Partners BVF 99,000 $17.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
07/16/98 Partners ILL10 10,000 $17.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
07/16/98 Partners PAL 6,000 $17.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
07/16/98 Partners ZPG 5,000 $17.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
07/16/98 Partners BVF Ltd. 80,000 $17.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
07/22/98 Partners BVF Ltd. 7,500 $18.0625 Purchase NB
- -------------------------------------------------------------------------------------------------------------
07/23/98 Partners BVF 1,000 $17.6875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/23/98 Partners ZPG 1,000 $17.6875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------------------
SETTLEMENT FOR THE PRICE PER
DATE BY ACCOUNT OF QUANTITY SHARE TYPE OF TRADE BROKER
- -------------------------------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C>
07/23/98 Partners BVF Ltd. 1,000 $17.6875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/24/98 Partners BVF 2,000 $17.5000 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/24/98 Partners PAL 1,000 $17.5000 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/24/98 Partners BVF Ltd. 1,000 $17.5000 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/27/98 Partners BVF 16,000 $17.2518 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/27/98 Partners ILL10 2,800 $17.2518 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/27/98 Partners BVF Ltd. 16,000 $17.2518 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/28/98 Partners BVF 12,000 $17.0118 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/28/98 Partners PAL 3,000 $17.0118 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/28/98 Partners ZPG 2,000 $17.0118 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/28/98 Partners BVF Ltd. 10,000 $17.0118 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/28/98 Partners BVF 12,000 $17.1250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/28/98 Partners PAL 3,000 $17.1250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/28/98 Partners ZPG 1,000 $17.1250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/28/98 Partners BVF Ltd. 9,000 $17.1250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners BVF 8,200 $16.9375 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners ILL10 1,600 $16.9375 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners PAL 1,200 $16.9375 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners ZPG 800 $16.9375 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners BVF Ltd. 8,200 $16.9375 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners BVF 1,000 $17.1213 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners ILL10 500 $17.1213 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners BVF Ltd. 1,000 $17.1213 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners BVF (31,320) $17.1250 Sale BEST
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners ILL10 (6,960) $17.1250 Sale BEST
- -------------------------------------------------------------------------------------------------------------
07/29/98 Partners BVF Ltd. (31,320) $17.1250 Sale BEST
- -------------------------------------------------------------------------------------------------------------
07/30/98 Partners BVF 1,500 $16.8196 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/30/98 Partners ILL10 2,300 $16.8196 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/30/98 Partners BVF Ltd. 1,500 $16.8196 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/30/98 Partners BVF 2,500 $17.0000 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
07/30/98 Partners BVF Ltd. 2,500 $17.0000 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------------------
SETTLEMENT FOR THE PRICE PER
DATE BY ACCOUNT OF QUANTITY SHARE TYPE OF TRADE BROKER
- -------------------------------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C>
07/31/98 Partners BVF 2,000 $16.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
07/31/98 Partners ILL10 8,000 $16.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
07/31/98 Partners BVF 8,000 $16.7500 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
07/31/98 Partners BVF Ltd. 7,000 $16.7500 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
07/31/98 Partners BVF 100 $16.8125 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/31/98 Partners BVF 5,000 $16.9375 Purchase INET
- -------------------------------------------------------------------------------------------------------------
07/31/98 Partners BVF Ltd. 5,000 $16.9375 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/03/98 Partners BVF 10,000 $16.8750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/03/98 Partners BVF Ltd. 10,000 $16.8750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/03/98 Partners BVF 6,000 $16.8750 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
08/03/98 Partners BVF Ltd. 9,000 $16.8750 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
08/03/98 Partners BVF 7,000 $16.6563 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/03/98 Partners ILL10 2,000 $16.6513 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/03/98 Partners ZPG 1,000 $16.6562 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/04/98 Partners BVF 2,000 $16.6250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/04/98 Partners BVF Ltd. 2,000 $16.6250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/04/98 Partners BVF 7,000 $16.8750 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
08/04/98 Partners BVF Ltd. 8,000 $16.8750 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners BVF 4,600 $16.2500 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners BVF Ltd. 4,000 $16.2500 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners BVF 10,000 $16.6250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners BVF Ltd. 10,000 $16.3750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners BVF 22,000 $16.5000 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners BVF Ltd. 19,750 $16.5000 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners ILL10 3,750 $16.4792 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners PAL 2,650 $16.4792 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/05/98 Partners ZPG 1,850 $16.4792 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/06/98 Partners BVF 7,000 $16.3125 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/06/98 Partners ILL10 1,000 $16.3125 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/06/98 Partners BVF Ltd. 7,000 $16.3125 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/06/98 Partners BVF 2,000 $16.3727 Purchase INET
- -------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------------------
SETTLEMENT FOR THE PRICE PER
DATE BY ACCOUNT OF QUANTITY SHARE TYPE OF TRADE BROKER
- -------------------------------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C>
08/06/98 Partners BVF Ltd. 2,000 $16.3727 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/07/98 Partners BVF 1,700 $14.8162 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/07/98 Partners BVF 2,000 $14.8750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/07/98 Partners BVF Ltd. 3,000 $14.8750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/07/98 Partners BVF 2,500 $14.7500 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
08/07/98 Partners BVF Ltd. 2,500 $14.7500 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
08/10/98 Partners BVF 600 $14.8750 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/11/98 Partners BVF 3,700 $15.6875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/11/98 Partners ILL10 400 $15.6875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/11/98 Partners PAL 300 $15.6875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/11/98 Partners ZPG 200 $15.6875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/11/98 Partners BVF Ltd. 3,400 $15.6875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/12/98 Partners BVF 5,500 $16.7260 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/12/98 Partners ILL10 1,500 $16.7260 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/12/98 Partners BVF Ltd. 5,000 $16.7260 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/12/98 Partners BVF 2,500 $16.5625 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/12/98 Partners BVF Ltd. 2,500 $16.5625 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/19/98 Partners BVF 900 $16.1250 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/19/98 Partners BVF 36,000 $16.3750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/19/98 Partners ILL10 4,000 $16.3750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/19/98 Partners PAL 2,000 $16.3750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/19/98 Partners ZPG 2,000 $16.3750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/19/98 Partners BVF Ltd. 36,000 $16.3750 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/20/98 Partners BVF 5,000 $16.2500 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/20/98 Partners BVF Ltd. 5,000 $16.2500 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/21/98 Partners BVF 6,000 $16.2188 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/21/98 Partners BVF Ltd. 7,600 $16.2188 Purchase INET
- -------------------------------------------------------------------------------------------------------------
08/28/98 Partners BVF 8,000 $14.7500 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/28/98 Partners BVF Ltd. 12,000 $14.7500 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/31/98 Partners BVF 3,000 $13.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
08/31/98 Partners BVF Ltd. 7,000 $13.6250 Purchase OPCO
- -------------------------------------------------------------------------------------------------------------
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
- -------------------------------------------------------------------------------------------------------------
SETTLEMENT FOR THE PRICE PER
DATE BY ACCOUNT OF QUANTITY SHARE TYPE OF TRADE BROKER
- -------------------------------------------------------------------------------------------------------------
- -------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C>
08/31/98 Partners BVF 3,200 $13.9395 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/01/98 Partners BVF 3,500 $13.2500 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/01/98 Partners BVF Ltd. 2,500 $13.2500 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/02/98 Partners BVF 1,000 $13.1875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/02/98 Partners ILL10 800 $13.1875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/02/98 Partners BVF Ltd. 1,000 $13.1875 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/02/98 Partners BVF 15,000 $13.2500 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
09/02/98 Partners ILL10 5,000 $13.2500 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
09/02/98 Partners BVF Ltd. 15,000 $13.2500 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners BVF 7,800 $12.1769 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners ILL10 2,000 $12.1769 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners PAL 3,000 $12.1769 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners ZPG 2,000 $12.1769 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners BVF Ltd. 7,000 $12.1769 Purchase INET
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners BVF 12,000 $12.3000 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners ILL10 3,000 $12.3000 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners ZPG 2,000 $12.3000 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
09/03/98 Partners BVF Ltd. 8,000 $12.3000 Purchase COWN
- -------------------------------------------------------------------------------------------------------------
</TABLE>
BTAB = BT Alex Brown
COWN = Cowen & Co.
INET = Instinet
MLCO = Merrill Lynch & Co.
NB = No Broker
