GUILFORD PHARMACEUTICALS INC
S-4/A, EX-8.02, 2000-08-01
PHARMACEUTICAL PREPARATIONS
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216-586-3939
                             [JONES DAY LETTERHEAD]
                                                                    EXHIBIT 8.02


                                August 1, 2000

Gliatech Inc.
23420 Commerce Park Road
Cleveland, Ohio  44122


Gentlemen:

                  You have requested our opinion regarding the applicability,
and the consequences of the applicability, of Section 368(a) of the Internal
Revenue Code of 1986, as amended (the "Code"), to the statutory merger of St.
John Development Corp. ("Merger Subsidiary"), a Delaware corporation and a
wholly-owned subsidiary of Guilford Pharmaceuticals, Inc. ("Parent"), a Delaware
corporation, with and into Gliatech Inc. ("Company"), a Delaware corporation,
pursuant to the Delaware General Corporation Law and Article I of the Agreement
and Plan of Merger, dated as of May 29, 2000, by and among Company, Merger
Subsidiary, and Parent, as amended by the letter agreement, dated as of June 9,
2000, by and among Company, Merger Subsidiary, and Parent (the "Merger
Agreement"). In addition, you have requested our opinion regarding whether
Parent and Company will each be a party to the reorganization within the meaning
of Section 368(b) of the Code.

                  This opinion is being delivered to you pursuant to Section
7.3(d) of the Merger Agreement, and addresses solely the U.S. federal income tax
matters referred to above. Capitalized terms used but not defined herein shall
have the same meanings ascribed to such terms in the Merger Agreement.

                  For purposes of rendering this opinion, we have examined such
existing documents and records of Company, Merger Subsidiary, and Parent as we
have deemed necessary or appropriate, as well as the Merger Agreement, other
documents relating to the Merger, and the proxy statement-prospectus which
Company will send to its shareholders in connection with the special meeting of
shareholders at which the Merger will be approved. With your consent we have
also relied upon the accuracy at all material times of the representations by
Parent and Company contained in separate tax certification letters dated June
16, 2000 and addressed to us, and have, with your permission, assumed that all
such representations are true at

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all material times without regard to any knowledge qualifier that may be set
forth therein. We assume that the Merger Agreement and each of the other
documents executed or finalized in connection with the Merger have not been, and
will not be, amended prior to the Effective Time. We also assume that following
the Merger, Parent will not cause Company to issue additional shares of its
stock that would result in Parent losing control of Company within the meaning
of Section 368(c) of the Internal Revenue Code of 1986, as amended (the "Code").
We further assume that a holder of Company Common Stock holds the shares of
Company Common Stock as a capital asset within the meaning of Section 1221 of
the Code at the Effective Time. We also confirm that, in rendering our opinion
in this matter, we have examined fully all such matters of law as in our
judgment we deemed necessary or appropriate to enable us to opine on the
matters that you have asked us to consider.

                  Based upon the foregoing, we are of the opinion that:

         (i)      the merger of Merger Subsidiary with and into Company pursuant
                  to Article I of the Merger Agreement will constitute a
                  "reorganization" within the meaning of Section 368(a) of the
                  Code;

         (ii)     Parent and Company will each be a party to the reorganization
                  within the meaning of Section 368(b) of the Code;

         (iii)    Parent and Company will not recognize any gain or loss
                  pursuant to the Merger;

         (iv)     no gain or loss will be recognized by a Company stockholder as
                  a result of the receipt solely of shares of Parent Common
                  Stock pursuant to the Merger, except to the extent of any cash
                  received in lieu of fractional shares of Parent Common Stock;

         (v)      a Company stockholder who receives cash in lieu of a
                  fractional share of Parent Common Stock will be treated as if
                  the stockholder received the fractional share and then sold
                  the share back to Parent. The stockholder will recognize gain
                  or loss on the sale of the fractional share equal to the
                  difference between the amount of cash received for the
                  fractional share and the stockholder's tax basis in the
                  fractional share;

         (vi)     a Company stockholder's aggregate tax basis in the Parent
                  Common Stock received pursuant to the Merger will initially be
                  equal to the stockholder's aggregate tax basis in the Company
                  Common Stock immediately prior to the Merger, reduced by the
                  amount of basis allocable to the fractional share; and

         (vii)    a Company stockholder's holding period for Parent Common Stock
                  received in exchange for Company Common Stock pursuant to the
                  Merger will include the holding periods of the Company Common
                  Stock.

                  Our opinion is based on the relevant provisions of the Code
and on administrative interpretations, judicial decisions, and regulations
thereunder or pertaining thereto as in effect on the date of this letter. These
authorities are subject to change, which could be either prospective or
retroactive in nature, and we can provide no assurance as to the effect that any
such change


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may have on the opinion that we have expressed above. We assume no obligation to
inform you of any such change.

                  This opinion is being furnished to you solely for the benefit
of Company and its stockholders. We hereby consent to the filing of this opinion
as Exhibit 8.02 to the Registration Statement filed by Parent on Form S-4, and
to the reference to our Firm under the caption "Legal Matters" in the proxy
statement/prospectus constituting part of this Registration Statement.

                                                  Very truly yours,


                                                  /s/ Jones, Day, Reavis & Pogue





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