NEUROBIOLOGICAL TECHNOLOGIES INC /CA/
DEF 14A, 1996-10-11
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                        SCHEDULE 14A INFORMATION
            PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE
                    SECURITIES EXCHANGE ACT OF 1934
                     (Amendment No. ______________)


Filed by the Registrant    /X/
Filed by a party other than the Registrant   / /

Check the appropriate box:
/ /  Preliminary proxy statement
/ /  Confidential, for use of the Commission only (as permitted by
     Rule 14a-6(e)(2))
/X/  Definitive proxy statement
/ /  Definitive additional materials
/ /  Soliciting material pursuant to Sec. 240.14a-11(c) or Sec. 240.14a-12

                      Neurobiological Techonologies, Inc.
            ------------------------------------------------
            (Name of Registrant as Specified in Its Charter)

                       Neurobiological Technologies, Inc.
  ------------------------------------------------------------------------
  (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of filing fee (Check the appropriate box):

/X/  $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), 14a-6(i)(2)
     or Item 22(a)(2) or Schedule 14A

/ /  $500 per each party to the controversy pursuant to Exchange Act Rule
     14a-6(i)(3).

/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.


(1)  Title of each class of securities to which transactions applies:

- ----------------------------------------------------------------------------

(2)  Aggregate number of securities to which transactions applies:

- ----------------------------------------------------------------------------

(3)  Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing
fee is calculated and state how it was determined):

- ----------------------------------------------------------------------------

(4)  Proposed maximum aggregate value of transaction:

- ----------------------------------------------------------------------------

(5)  Total fee paid:

- ----------------------------------------------------------------------------

/ /  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee
     was paid previously.  Identify the previous filing by registration
     statement number, or the Form or Schedule and the date of its filing.

(1)  Amount previously paid:

- ----------------------------------------------------------------------------

(2)  Form, Schedule or Registration Statement No.:

- ----------------------------------------------------------------------------

(3)  Filing party:

- ----------------------------------------------------------------------------

(4)  Date filed:

- ----------------------------------------------------------------------------


<PAGE>


                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                              1387 Marina Way South
                           Richmond, California 94804
                                 (510) 215-8000


                                                                October 10, 1996

Dear Stockholder:

         You are cordially  invited to attend the Annual Meeting of Stockholders
of Neurobiological  Technologies,  Inc. which will be held on November 14, 1996,
at 10:00 A.M., at the World Trade Club, Room 300, World Trade Center  (adjoining
the Ferry Building at Embarcadero and Market Street), San Francisco, California.

         The formal notice of the Annual  Meeting and the Proxy  Statement  have
been made a part of this invitation.

         After reading the Proxy Statement,  please mark, date, sign and return,
at your  earliest  convenience,  the  enclosed  proxy  in the  prepaid  envelope
addressed to ChaseMellon  Shareholder  Services,  our transfer  agent, to ensure
that your shares will be  represented.  YOUR SHARES  CANNOT BE VOTED  UNLESS YOU
SIGN, DATE AND RETURN THE ENCLOSED PROXY OR ATTEND THE ANNUAL MEETING IN PERSON.

         A copy of the Company's Annual Report on Form 10-KSB is also enclosed.

         The Board of Directors and Management look forward to seeing you at the
meeting.


                                               Sincerely yours,




                                               Jeffrey S. Price, Ph.D.
                                               President and Chief
                                               Executive Officer

<PAGE>


                       NEUROBIOLOGICAL TECHNOLOGIES, INC.

                               -------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                          TO BE HELD NOVEMBER 14, 1996

                               -------------------

To the Stockholders of Neurobiological Technologies, Inc.:

         The Annual Meeting of  Stockholders  of  Neurobiological  Technologies,
Inc., a Delaware  corporation (the  "Company"),  will be held at the World Trade
Club, Room 300, World Trade Center  (adjoining the Ferry Building at Embarcadero
and Market  Street),  San  Francisco,  California on November 14, 1996, at 10:00
A.M., Pacific Standard Time, for the following purposes:

         1.  To elect the board of directors;

         2.  To  consider  and vote upon a  proposal  to amend and  restate  the
             Employee Stock Purchase Plan of Neurobiological Technologies, Inc.;

         3.  To ratify  the  appointment  of Ernst & Young LLP as the  Company's
             independent auditors; and

         4.  To transact  such other  business as may  properly  come before the
             Annual Meeting and any adjournment of the Annual Meeting.

         Stockholders  of record as of the close of  business on  September  25,
1996  are  entitled  to  notice  of and to vote at the  Annual  Meeting  and any
adjournment  thereof.  A complete list of stockholders  entitled to vote will be
available at the Secretary's  office, 1387 Marina Way South,  Richmond,  for ten
days before the meeting.

         IT IS IMPORTANT THAT YOUR SHARES ARE REPRESENTED AT THIS MEETING.  EVEN
IF YOU PLAN TO ATTEND THE MEETING,  WE HOPE THAT YOU WILL PROMPTLY  MARK,  SIGN,
DATE AND RETURN THE ENCLOSED PROXY. THIS WILL NOT LIMIT YOUR RIGHTS TO ATTEND OR
VOTE AT THE MEETING.


                                            By Order of the Board of Directors,


                                            Jeffrey S. Price, Ph.D.
                                            President and Chief
                                            Executive Officer

Richmond, California
October 10, 1996

<PAGE>

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.

                               ------------------

                                PROXY STATEMENT

                               ------------------

INFORMATION CONCERNING SOLICITATION AND VOTING

         This Proxy Statement is furnished in connection  with the  solicitation
by the Board of  Directors  of  Neurobiological  Technologies,  Inc., a Delaware
corporation (the "Company"),  of proxies in the accompanying  form to be used at
the Annual  Meeting of  Stockholders  to be held on  November  14,  1996 and any
adjournment  thereof  (the  "Annual  Meeting").  The shares  represented  by the
proxies received in response to this  solicitation and not revoked will be voted
at the Annual Meeting. A proxy may be revoked at any time before it is exercised
by filing  with the  Secretary  of the  Company a written  revocation  or a duly
executed  proxy  bearing a later  date or by  voting  in  person  at the  Annual
Meeting.  On the matters coming before the Annual Meeting for which a choice has
been specified by a stockholder by means of the ballot on the proxy,  the shares
will be voted accordingly.  If no choice is specified,  the shares will be voted
FOR the election of the nominees for director listed in this Proxy Statement and
FOR the amendments to the Employee Stock Purchase Plan and FOR  ratification  of
Ernst & Young LLP as the  Company's  independent  auditors as  described  in the
Notice of Annual  Meeting and in this Proxy  Statement  and will be voted in the
proxy holders'  discretion as to other matters that may properly come before the
Annual Meeting and any adjournment.

         Stockholders  of record at the close of business on September  25, 1996
are entitled to notice of and to vote at the Annual Meeting.  As of the close of
business  on such  date,  the  Company  had  6,515,483  shares of  Common  Stock
outstanding and entitled to vote. Each holder of Common Stock is entitled to one
vote for each share held as of the record date.

         Directors are elected by a plurality vote. The other matters  submitted
for  stockholder  approval  at  this  Annual  Meeting  will  be  decided  by the
affirmative  vote of a majority of shares  present in person or  represented  by
proxy and entitled to vote on each such matter.  Abstentions with respect to any
matter are treated as shares present or represented and entitled to vote on that
matter and thus have the same effect as negative  votes. If shares are not voted
by the broker who is the record holder of the shares, or if shares are not voted
in other  circumstances  in  which  proxy  authority  is  defective  or has been
withheld with respect to any matter, these non-voted shares are not deemed to be
present or represented for purposes of determining whether stockholder  approval
of that matter has been obtained.

         The expense of printing and mailing  proxy  materials  will be borne by
the Company.  In addition to the  solicitation of proxies by mail,  solicitation
may be made by certain directors, officers and other employees of the Company by
personal interview,  telephone or facsimile.  No additional compensation will be
paid to such persons for such solicitation. The Company will reimburse brokerage
firms and  others  for their  reasonable  expenses  in  forwarding  solicitation
materials to beneficial owners of the Company's Common Stock.

         This  Proxy  Statement  and the  accompanying  form of proxy  are being
mailed on or about October 10, 1996 to all stockholders  entitled to vote at the
meeting.

                                    IMPORTANT

         Please  mark,  sign and date the  enclosed  proxy and return it at your
earliest  convenience in the enclosed  postage-prepaid  return envelope so that,
whether you intend to be present at the Annual  Meeting or not,  your shares can
be  voted.  This  will not limit  your  rights  to attend or vote at the  Annual
Meeting.

<PAGE>

                                   PROPOSAL 1

                              ELECTION OF DIRECTORS

Nominees

         The Board of Directors proposes the election of the following directors
of the Company for a term of one year.  Directors are elected to serve until the
next annual meeting of stockholders  and until their  successors are elected and
qualified. If any nominee is unable or declines to serve as director at the time
of the Annual Meeting,  proxies will be voted for any nominee  designated by the
Board of Directors to fill the vacancy.

         Names of the nominees and certain  biographical  information about them
are set forth below:

         Jeffrey S. Price,  Ph.D.,  age 54, has been President and a director of
the  Company  since he joined the  Company  in  October  1990 and has been Chief
Executive  Officer  since April 1991.  Dr. Price also served as Chief  Operating
Officer of the Company from October 1990 until April 1991.  Before  joining NTI,
he was employed for 14 years with Cetus Corporation ("Cetus"), which merged with
Chiron  Corporation in 1991, serving as Vice President from 1982 until 1986, and
as Senior Vice President of Research and Development from 1986 until April 1990,
in which  positions he held  responsibility  for Cetus'  corporate  research and
development  operation and organization.  This organization engaged in discovery
research into novel  therapeutics  and diagnostics  using the tools and insights
gained from modern molecular biology,  and in the design of novel  manufacturing
processes for finished  products.  Dr. Price's group managed the  development of
several  investigational new drugs, two of which have been subsequently approved
for  commercial  sale,  and also  developed  PCR, a powerful  gene-amplification
technology with  applications in discovery  research and diagnostics.  Dr. Price
holds a B.A.  degree from The  Colorado  College and M.A.  and Ph.D.  degrees in
Biology from Rice University.

         Abraham E.  Cohen,  age 60, has been a director  of the  Company  since
March 1993 and has been  Chairman of the Board of  Directors  since August 1993.
From 1982 to 1992,  Mr.  Cohen  served as Senior Vice  President  of Merck & Co.
("Merck")  and  from  1977 to  1988  as  President  of the  Merck  Sharp & Dohme
International  Division  ("MSDI").  While at Merck,  he played a key role in the
development of Merck's international business, initially in Asia, then in Europe
and,  subsequently,  as President of MSDI, which  manufactures and markets human
health products  outside the United States.  Since his retirement from Merck and
MSDI in January  1992,  Mr. Cohen has been active as an  international  business
consultant.  He is a director of six public companies:  Agouron Pharmaceuticals,
Inc.,  Akzo  N.V.,   Immunomedics,   Teva   Pharmaceutical   Industries,   Ltd.,
Vasomedical, Inc., and Vion Pharmaceuticals, Inc.

         Enoch  Callaway,  M.D.,  age 72, is a founder  of the  Company  and has
served  as a  director  of  the  Company  since  September  1987.  Dr.  Callaway
previously  served as Chairman  of the Board of  Directors  of the Company  from
September  1987 to November 1990, as Co-Chairman of the Board from November 1990
until August 1993, as Vice  President  from September 1988 until August 1993 and
as Secretary  from September 1988 until  September  1991. Dr.  Callaway has been
Emeritus Professor of Psychiatry at the University of California,  San Francisco
since 1986,  where he also served as Director of Research at the Langley  Porter
Psychiatric  Institute  from 1959 to 1988.  He holds A.B. and M.D.  degrees from
Columbia University.

         Theodore L.  Eliot,  Jr.,  age 68,  served as a director of the Company
from September 1988 until April 1992 and as a Vice President from September 1988
until September  1991. He  subsequently  has served as a director of the Company
since August 1992. Mr. Eliot retired from the United States  Department of State
in 1978  with the rank of  Ambassador.  He  served  as the Dean of the  Fletcher
School of Law and Diplomacy  from 1979 to 1985 and as Secretary  General for the
United States of the Bilderberg Meetings from 1981 to October 1993. Mr. Eliot is
a  director  of  two  publicly-held   companies,   Raytheon  Company,  Inc.  and
Fiberstars,   Inc.  Mr.  Eliot  holds  B.A.  and  M.P.A.  degrees  from  Harvard
University.

         Lawrence G. Mohr, Jr., age 51, has been a director of the Company since
April 1992. He is a general partner of Mohr, Davidow Ventures, a venture capital
firm that he  founded in 1983.  Previously,  Mr.  Mohr was a general  partner of
Hambrecht & Quist and a Vice President of BankAmerica Capital  Corporation.  Mr.
Mohr holds a B.S.  degree in  engineering  from Cornell  University  and an M.S.
degree in engineering and an M.B.A. degree from Stanford University. Mr. Mohr is
a director of 3 publicly held companies,  Cardiac Pathways  Corporation,  Fusion
Medical, Inc., and VitaMed, Inc.

                                      -2-
<PAGE>

         John B.  Stuppin,  age 63, is a founder of the  Company  and has been a
director of the Company since September 1988 and Treasurer from April 1991 until
July 1994.  From  September  1987 until  October  1990,  Mr.  Stuppin  served as
President of the Company,  from November 1990 to August 1993, as  Co-Chairman of
the Board of Directors and, from October 1990 until September 1991, as Executive
Vice  President.  He also served as the acting  Chief  Financial  Officer of the
Company from the Company's  inception  through  December 1993. Mr. Stuppin is an
investment banker and a venture  capitalist.  He has over 25 years experience in
the start up and management of companies active in emerging technologies and has
been the president of a manufacturing  company.  He is a director of Fiberstars,
Inc. Mr. Stuppin holds an A.B. degree from Columbia College.

         The Board of  Directors  recommends a vote FOR election for director of
the nominees set forth above.

Board Meetings and Committees

         The Board of Directors held nine meetings  during the fiscal year ended
June 30, 1996.  All directors  attended at least 75% of the aggregate  number of
meetings of the Board of Directors and of the committees on which such directors
serve.

         The Board of Directors  has appointed a  Compensation  and Stock Option
Committee, an Audit Committee and a Nominating Committee.

         The members of the Compensation and Stock Option Committee are Theodore
L.  Eliot,  Jr. and  Lawrence G. Mohr,  Jr. The  Compensation  and Stock  Option
Committee held three meetings  during fiscal 1996.  The  Compensation  and Stock
Option Committee's functions are to assist in the implementation of, and provide
recommendations with respect to general and specific  compensation  policies and
practices  of the  Company,  including  the  administration  of and  granting of
options under the Company's 1993 Stock Plan.

         The members of the Audit  Committee  are  Theodore  L.  Eliot,  Jr. and
Lawrence G. Mohr,  Jr. The Audit  Committee held one meeting during fiscal 1996.
The Audit  Committee's  functions  are to review the scope of the annual  audit,
monitor the  independent  auditor's  relationship  with the Company,  advise and
assist the Board of Directors in evaluating the auditor's examination, supervise
the Company's financial and accounting  organization and financial reporting and
nominate for stockholder  approval at the annual  meeting,  with the approval of
the Board of Directors,  a firm of certified public accountants whose duty it is
to audit the  financial  records of the Company for the fiscal year for which it
is appointed.

         The members of the  Nominating  Committee  are Dr.  Enoch  Callaway and
Messrs. Lawrence G. Mohr, Jr. and John B. Stuppin. The Nominating Committee held
no meetings  during fiscal 1996.  The Nominating  Committee is  responsible  for
matters  relating  to the  composition  of the  Board  of  Directors,  including
recruitment,  nomination  and  succession.  Stockholders  wishing  to  submit  a
proposal for nominee(s) for director must submit such proposals to the Secretary
of the  Company  120  calendar  days  prior to the date of the  Company's  proxy
statement in  connection  with the previous  years  annual  meeting.  

                                      -3-
<PAGE>

Directors' Compensation

         Other than Mr. Cohen,  who receives $30,000 per year for his service as
a  director,  directors  do not  receive  any fees for  service  on the Board of
Directors.  Mr.  Cohen is also  reimbursed  for his  expenses  for each  meeting
attended.  In January 1995,  Mr. Cohen was granted an option to purchase  20,000
shares of Common  Stock at an  exercise  price of $2.88  per share  which  vests
monthly over a four-year period from the date of grant.  Non-employee  directors
are currently  eligible to participate in the Company's 1993 Stock Plan pursuant
to which they will  receive  automatic  annual  grants of  options to  purchases
shares of the Company's  Common Stock.  Subject to the 1993 Stock Plan, each new
non-employee  director of the Company will  receive an option to purchase  5,000
shares of Common  Stock on the date of his or her  election  to the Board at the
fair market value on the date of grant. Thereafter,  upon the conclusion of each
regular annual meeting of the Company's stockholders, each non-employee director
continuing to serve on the Board of Directors will receive an option to purchase
1,000 shares of the Company's  Common Stock.  In November 1995,  Messrs.  Cohen,
Eliot,  and Mohr  each  received  an  option  to  purchase  1,000  shares of the
Company's common stock, which vest one year from the date of grant.

Compensation Committee Interlocks and Insider Participation

         The  Compensation  Committee  of the  Board of  Directors  consists  of
Messrs.  Eliot and Mohr, who are outside  directors.  Between September 1988 and
September 1991, Mr. Eliot served as a Vice President of the Company.

                                      -4-

<PAGE>

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The following table sets forth certain  information as of September 25,
1996 as to shares of the Company's Common Stock  beneficially owned by: (i) each
person  who is known by the  Company  to own  beneficially  more  than 5% of the
Company's Common Stock, (ii) each of the Company's directors,  (iii) each of the
Company's officers named under "Executive  Compensation -- Summary  Compensation
Table," and (iv) all directors and executive officers of the Company as a group.

                                                    Shares         Percentage
              Name  of                           Beneficially     Beneficially 
            Beneficial Owner                       Owned(1)         Owned(1)
         -----------------------               ----------------  --------------

      Mohr, Davidow Ventures II and III(2).....      643,910          9.6%
         3000 Sand Hill Road                       
         Building One, Suite 240                   
         Menlo Park, CA 94025                      
                                                   
      Enoch Callaway, M.D.(3)..................      105,827          1.6
      Abraham E. Cohen(4)......................       47,248          *
      Theodore L. Eliot, Jr.(5)................       25,744          *
      Ronald Goldblum, M.D.(6).................       32,063          *
      Behzad Khosrovi(7).......................       84,999          1.3
      Lawrence G. Mohr, Jr.(2).................      652,052          9.7
      Michael S. Ostrach (8)...................       79,882          1.2
      Jeffrey S. Price(9)......................      192,828          2.9
      John B. Stuppin(10)......................      212,865          3.3
                                                   
      All directors and executive officers         
         as a group (12 persons)(11)...........    1,563,610         21.4
      ----------------                             
      * Less than 1%.                              

(1)      To the  Company's  knowledge,  the persons named in the table have sole
         voting and investment  power with respect to all shares of Common Stock
         shown as beneficially owned by them, subject to community property laws
         where applicable and the information contained in the footnotes to this
         table.

(2)      Includes an aggregate of 200,900  shares of Common Stock  issuable upon
         the  exercise  of  warrants  held by  Mohr,  Davidow  Ventures  ("Mohr,
         Davidow").  Lawrence  G. Mohr,  Jr., a director  of the  Company,  is a
         General  Partner  of  Mohr,  Davidow.  Mr.  Mohr  disclaims  beneficial
         ownership of shares held by or issuable to Mohr, Davidow, except to the
         extent  of  his  pecuniary  interest  therein.  Mr.  Mohr's  individual
         holdings  include  4,000 shares of Common Stock and options to purchase
         4,142  shares of Common Stock  exercisable  within 60 days of September
         25, 1996 held directly by Mr. Mohr.

(3)      Includes  79,444  shares of Common  Stock  held by Enoch  Callaway  and
         Dorothy C.  Callaway,  Trustees or  Successor  Trustees of the Callaway
         1989 Trust, Executed May 20, 1989 (the "Callaway Trust"). Also includes
         669 shares of Common Stock  issuable upon exercise of a warrant held by
         the  Callaway  Trust and  options to purchase  25,714  shares of Common
         Stock  exercisable  within 60 days of  September  25,  1996 held by Dr.
         Callaway, a director of the Company. Dr. Callaway may be deemed to have
         a beneficial interest in the shares held by the Callaway Trust.

(4)      Includes 41,048 shares subject to stock options  exercisable  within 60
         days of September 25, 1996.

(5)      Includes  21,294 shares of Common Stock held by Theodore L. Eliot,  Jr.
         and Patricia P. Eliot, Trustees, the Eliot Trust, Executed February 27,
         1987 (the "Eliot  Trust").  Also  includes  334 shares of Common  Stock
         issuable upon exercise of a warrant held by the Eliot Trust and options
         to purchase 4,116 shares of Common Stock exercisable  within 60 days of
         September  25, 1996 held by Mr. Eliot,  a director of the Company.  Mr.
         Eliot may be deemed to have a beneficial interest in the shares held by
         the Eliot Trust.

(6)      Includes 32,063 shares subject to stock options  exercisable  within 60
         days of September 25, 1996.

                                      -5-
<PAGE>

(7)      Includes 78,199 shares subject to stock options  exercisable  within 60
         days of September 25, 1996.

(8)      Includes 74,979 shares subject to stock options  exercisable  within 60
         days of September 25, 1996.

(9)      Includes 187,608 shares subject to stock options  exercisable within 60
         days of September 25, 1996.

(10)     Includes 199,057 shares of Common Stock and warrants to purchase 10,380
         shares of Common  Stock held by John B.  Stuppin  and Jane K.  Stuppin,
         Trustees UTD dated March 11, 1991 (the "Stuppin  Trust").  Mr.  Stuppin
         may be deemed to have a  beneficial  interest in the shares held by the
         Stuppin Trust.  Also includes 500 shares held by Mr.  Stuppin's  spouse
         and 3,428 shares subject to stock options exercisable within 60 days of
         September 25, 1996. Excludes 10,268 shares held in a trust of which Mr.
         Stuppin's  spouse  is a  co-trustee  and  co-beneficiary.  Mr.  Stuppin
         disclaims voting or dispositive control over such shares.

(11)     Includes shares included  pursuant to notes 2-10, and includes  122,367
         additional shares subject to stock options  exercisable  within 60 days
         of September 25, 1996.


                             EXECUTIVE COMPENSATION

<TABLE>
Summary Compensation Table

         The following table sets forth  compensation  for services  rendered in
all capacities to the Company for the fiscal years ended June 30, 1994, 1995 and
1996 of (i) the Company's Chief  Executive  Officer and (ii) the Company's other
most highly  compensated  executive officers whose total annual salary and bonus
for fiscal year 1996 exceeded $100,000 (the "Named Officers").

                           Summary Compensation Table

<CAPTION>

                                                      Annual Compensation                   Long-Term 
                                                                                        Compensation Awards
                                       ------------------------------------------       -------------------

                                       Fiscal Year     Salary($)        Bonus ($)           Options (#)
                                       ------------    ----------       ---------           -----------

<S>                                        <C>            <C>             <C>                <C>         
     Jeffrey S. Price                      1996           175,000              --                --
        President and                      1995           168,000              --            33,000
        Chief Executive Officer            1994           146,667          20,000           214,293 (1)

     Michael S. Ostrach                    1996           150,000              --                --
        Executive Vice President           1995           145,500              --            21,000
        Chief Operating Officer            1994            11,667              --           125,000

     Ronald Goldblum                       1996           155,000              --             8,000
         Vice President                    1995            71,042              --            65,000
         Medical Affairs

     Behzad Khosrovi                       1996           125,000              --             2,000
        Vice President                     1995           120,500              --             9,000
        Pharmaceuticals Development        1994           105,005          15,000            92,146 (2)
<FN>

- ---------------------

(1)      Includes an option  grant for 136,076  shares and  separate  grants for
         78,217 shares in return for  cancellation  of  outstanding  options for
         78,217 shares granted in October 1990.

(2)      Includes  an option  grant for 71,788  shares and a separate  grant for
         20,358 shares in return for  cancellation  of  outstanding  options for
         20,358 shares granted in January 1992.
</FN>
</TABLE>
                                      -6-
<PAGE>

<TABLE>
Stock Option Grants in 1996 Fiscal Year

         The following  tables summarize option grants to, and exercises by, the
Named  Officers  during  fiscal 1996,  and the value of the options held by each
such person at the end of fiscal  1996.  Jeffrey S. Price and Michael S. Ostrach
were not granted any options during fiscal 1996.



                          Option Grants in Fiscal 1996
<CAPTION>
                                                                                                  Potential Realizable
                                                                                                Value at Assumed Annual
                                                                                                     Rates of Stock
                                                   Individual Grants                            Appreciation for Option
                                                                                                        Term(4)
                            ----------------------------------------------------------------   ---------------------------
                                                  % of Total
                                                    Options
                                                  Granted to       Exercise
                                  Options        Employees in        Price       Expiration
                                Granted(#)       Fiscal Year       ($/Sh)(2)       Date(3)          5%($)        10%($)
                                ----------       ------------      ---------     -----------       -------       ------

<S>                              <C>                     <C>         <C>          <C>               <C>          <C>
Ronald Goldblum
   Vice President                8,000 (1)               11          6.63         06/20/06          33,331       84,468
   Medical Affairs

Behzad Khosrovi
   Vice President,               2,000 (1)                3          6.63         06/20/06           8,333       21,117
   Pharmaceuticals
   Development
<FN>
- ------------

 (1)     Options vest on June 20,  2006,  subject to earlier  acceleration  upon
         achievement  of  performance  objectives as determined by  compensation
         committee.

(2)      The  exercise  price on the date of grant was equal to 100% of the fair
         market value on the date of grant.

(3)      The options have  specified  terms,  subject to earlier  termination in
         certain events related to termination of employment.

(4)      The 5% and 10% assumed rates of appreciation  are mandated by the rules
         of the  Securities  and Exchange  Commission  and do not  represent the
         Company's estimate or projection of the future Common Stock price.
</FN>
</TABLE>

                                      -7-

<PAGE>

<TABLE>
Aggregated  Option  Exercises  in Fiscal  Year 1996 and  Fiscal  Year End Option
Values

         The following  table contains  information  relating to the exercise of
options by the Named Officers during fiscal 1996.

                         Option Exercises in Fiscal 1996
                     and Fiscal 1996 Year-End Option Values
<CAPTION>

                                                                                                           Value of
                                                                  Number of Unexercised                   Unexercised
                                                                         Options at              In-the-Money Options at Fiscal
                                                                     Fiscal Year End(#)                  Year End($)(1)
                                 Shares                        -----------------------------     ------------------------------
                              Acquired on         Value
                             Exercise (#)      Realized ($)      Exercisable/Unexercisable         Exercisable/Unexercisable
                             ------------      ------------    -----------------------------     ------------------------------

<S>                                 <C>             <C>               <C>                               <C>
Jeffrey S. Price
   President and Chief
   Executive Officer                0               0                 173,433 / 73,860                  508,359 / 235,769

Michael S. Ostrach
  Executive Vice President
  Chief Operating Officer           0               0                  74,979/ 71,021                    52,654 / 88,596

Ronald Goldblum
   Vice President
   Medical Affairs                  0               0                 32,063 / 40,937                    84,165 / 86,460

Behzad Khosrovi
   Vice President,
   Pharmaceuticals
   Development                      0               0                 78,199 / 24,947                   229,806 / 70,707
<FN>
- ------------

(1)      Calculated  on the  basis of the fair  market  value of the  underlying
         securities at June 30, 1996 ($6.63 per share) minus the exercise price.
</FN>
</TABLE>


Employment Agreements

         The Company has an  agreement  with Mr.  Ostrach  dated June 22,  1996,
which provides that, should Mr. Ostrach's  employment with the Company terminate
for any reason,  he is entitled to receive his annual base  compensation  and to
continue to  participate,  as if he were an  employee,  in the  Company's  group
insurance  plans,  from the date upon which his  termination  becomes  effective
until the earliest of (i) the date twelve  months after the date of  termination
(ii) the date he commences full time employment with another employer,  or (iii)
the date of his death.  Further,  should Mr. Ostrach's employment be terminated,
his stock options will become exercisable in full on the date of termination.

Pension and Long-Term Incentive Plans

         The Company has no pension or long-term incentive plans.

                                      -8-
<PAGE>

                                   PROPOSAL 2

                      APPROVAL OF THE AMENDED AND RESTATED
                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                          EMPLOYEE STOCK PURCHASE PLAN

         In order to provide employees of the Company an opportunity to purchase
Common Stock through payroll deductions,  the Board of Directors has adopted the
Amended and Restated Neurobiological Technologies,  Inc. Employee Stock Purchase
Plan (as amended and  restated,  the "ESPP") under which 50,000 shares of Common
Stock have been reserved for issuance,  subject to anti-dilution provisions. The
stockholders  approved the adoption of the ESPP in January  1994.  On August 22,
1996,  the Board of  Directors  amended  and  restated  the ESPP to  reserve  an
additional  50,000 shares for issuance under the ESPP subject to the approval of
the  Company's  stockholders  at the Annual  Meeting.  As of October 1, 1996, an
aggregate of 7,653 shares were available for issuance under the ESPP.

         The full text of the ESPP,  substantially  in the form in which it will
take effect if the ESPP is approved by the shareholders, is set forth in Exhibit
A to this Proxy  Statement.  The  following  description  of the ESPP is summary
only. It is subject to, and qualified in its entirety by, Exhibit A.

         Under the ESPP,  an aggregate of 100,000  shares of Common Stock (which
number includes the 50,000-share  increase that the shareholders are being asked
to  approve)  have  been  reserved  for  issuance,   subject  to   anti-dilution
provisions.  Any full-time  employee will be eligible to participate in the ESPP
after  he or she  has  been  continuously  employed  by the  Company  for  three
consecutive   months.  The  Company  currently  has  25  employees  eligible  to
participate  in  the  ESPP.  Eligible  employees  participate  in  the  ESPP  by
authorizing  payroll deductions up to 10% of their total cash compensation,  not
to exceed  $25,000 per year. At the end of each six month offering  period,  the
Company will apply the amount contributed by the participant during the offering
period to purchase whole shares of Common Stock, but not more than 2,500 shares.
Shares of Common Stock are purchased at 85% of the lower of (i) the market price
of Common Stock  immediately  before the  beginning of the  applicable  offering
period  or (ii)  the  market  price  of such  Common  Stock  at the  time of the
purchase.  All  expenses  incurred in  connection  with the  implementation  and
administration of the ESPP will be paid by the Company.

Required Approval

         In order to be adopted,  a majority of the shares entitled to vote must
vote on this proposal and it must receive the affirmative  vote of a majority of
the shares voting.

         The  Board  of  Directors  recommends  a vote FOR the  adoption  of the
amendment and restatement of the  Neurobiological  Technologies,  Inc.  Employee
Stock Purchase Plan.

                                   PROPOSAL 3

                      RATIFICATION OF INDEPENDENT AUDITORS

         Upon the recommendation of the Audit Committee,  the Board of Directors
has  appointed  the  firm  of  Ernst & Young  LLP as the  Company's  independent
auditors for the fiscal year ended June 30, 1997, subject to ratification by the
stockholders.  Ernst & Young LLP has audited the Company's financial  statements
since  fiscal  1992.  Representatives  of Ernst & Young LLP are  expected  to be
present at the Company's Annual Meeting. They will have an opportunity to make a
statement,  if they  desire  to do so,  and  will be  available  to  respond  to
appropriate questions.

Required Approval

         In order to be adopted,  a majority of the shares entitled to vote must
vote on this proposal and it must receive the affirmative  vote of a majority of
the shares voting.

         The Board of Directors  recommends a vote FOR  ratification  of Ernst &
Young LLP as the Company's independent auditors.

                                      -9-
<PAGE>

                STOCKHOLDER PROPOSALS FOR THE 1997 ANNUAL MEETING

         Proposals  of  stockholders  of the  Company  that are  intended  to be
presented by such  stockholders  at the  Company's  1997 Annual  Meeting must be
received  by the  Secretary  of the  Company no later than June 12,  1997.  Such
proposals  may be included in the  Company's  proxy  statement and form of proxy
relating  to that  meeting if they  comply with  certain  rules and  regulations
promulgated by the Securities and Exchange Commission.

                                  OTHER MATTERS

         The Company  knows of no other  business  that will be presented at the
Annual  Meeting.  If any other  business is properly  brought  before the Annual
Meeting,  it is  intended  that  proxies in the  enclosed  form will be voted in
accordance with the judgment of the persons voting the proxies.

      COMPLIANCE WITH SECTION 16 (a) OF THE SECURITIES EXCHANGE ACT OF 1934

         Under  the  securities  laws  of  the  United  States,   the  Company's
directors,  executive  officers  and any  persons  holding  more than 10% of the
Company's  Common Stock are required to report  their  initial  ownership of the
Company's  Common  Stock and any  subsequent  changes in that  ownership  to the
Securities  and Exchange  Commission.  Specific due dates for these reports have
been established and the Company is required to identify in this Proxy Statement
those  persons  who  failed to timely  file  these  reports.  All of the  filing
requirements  were  satisfied for the fiscal year ended June 30, 1996. In making
this disclosure, the Company has relied solely on written representations of its
directors and executive  officers and copies of the reports that have been filed
with the Commission.

         Whether you intend to be present at the Annual  Meeting or not, we urge
you to return your signed proxy promptly.


                                     By  order  of  the Board of Directors.



                                     Jeffrey S. Price, Ph.D.
                                     President and Chief
                                     Executive Officer



Richmond, California
October 10, 1996

                                      -10-
<PAGE>


                                    Exhibit A





                              AMENDED AND RESTATED

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.

                          EMPLOYEE STOCK PURCHASE PLAN








<PAGE>


                                TABLE OF CONTENTS
                                -----------------
                                                                           Page
                                                                           ----

SECTION 1.  PURPOSE OF THE PLAN...........................................  1

SECTION 2.  ADMINISTRATION OF THE PLAN....................................  1

SECTION 3.  ENROLLMENT AND PARTICIPATION..................................  1

SECTION 4.  EMPLOYEE CONTRIBUTIONS........................................  2

SECTION 5.  WITHDRAWAL FROM THE PLAN......................................  3

SECTION 6.  TERMINATION OF EMPLOYMENT OR DEATH............................  3

SECTION 7.  PLAN ACCOUNTS AND PURCHASE OF SHARES..........................  3

SECTION 8.  LIMITATIONS ON STOCK OWNERSHIP................................  5

SECTION 9.  RIGHTS NOT TRANSFERABLE.......................................  5

SECTION 10.  NO RIGHTS AS AN EMPLOYEE.....................................  6

SECTION 11.  NO RIGHTS AS A STOCKHOLDER...................................  6

SECTION 12.  STOCK OFFERED UNDER THE PLAN.................................  6

SECTION 13.  AMENDMENT OR DISCONTINUANCE..................................  6

SECTION 14.  DEFINITIONS..................................................  7

SECTION 15.  EXECUTION....................................................  9

                                      -i-

<PAGE>


                              AMENDED AND RESTATED

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.

                          EMPLOYEE STOCK PURCHASE PLAN




1.  PURPOSE OF THE PLAN.


         The Plan was adopted by the  Company's  Board of  Directors on December
15, 1993, approved by the Company's stockholders in January 1994 and amended and
restated by the  Company's  Board of Directors  on August 22,  1996,  subject to
stockholder approval.

         The  purpose  of the  Plan is to  provide  Eligible  Employees  with an
opportunity to increase their proprietary interest in the success of the Company
by  purchasing  Stock from the  Company on  favorable  terms and to pay for such
purchases  through  payroll  deductions.  The Plan is intended to qualify  under
section 423 of the Internal Revenue Code of 1986, as amended.

2.  ADMINISTRATION OF THE PLAN.

         (a) The Committee. The Plan shall be administered by the Committee. The
interpretation and construction by the Committee of any provision of the Plan or
of any right to purchase  Stock granted  under the Plan shall be conclusive  and
binding on all persons.

         (b) Rules and Forms. The Committee may adopt such rules and forms under
the Plan as it considers appropriate.

3.  ENROLLMENT AND PARTICIPATION.

         (a)  Offering  Periods.  While the Plan is in effect,  two  overlapping
Offering  Periods shall  commence in each calendar  year.  The Offering  Periods
shall consist of the 24-month periods commencing on each January 1 and July 1.

         (b) Accumulation Periods. While the Plan is in effect, two Accumulation
Periods shall  commence in each calendar year.  The  Accumulation  Periods shall
consist of the six-month periods commencing on each January 1 and July 1.

         (c) Enrollment.  Any individual who, on the day preceding the first day
of an Offering Period,  qualifies as an Eligible  Employee may elect to become a
Participant  in the Plan for such Offering  Period by executing  the  enrollment
form prescribed for this purpose by the Committee.  The enrollment form shall be
filed with the  Company  not later than one week prior to the last  working  day
prior to the commencement of such Offering Period.

         (d) Duration of Participation. Once enrolled in the Plan, a Participant
shall continue to participate until he or she ceases to be an Eligible Employee,
withdraws from the Plan or reaches the end of the  Accumulation  Period in which
he  or  she   discontinued   contributions.   A  Participant  who   discontinued
contributions  under  Section 4(d) or withdrew  from the Plan under Section 5(a)
may again become a Participant,  if he or she then is an Eligible  Employee,  by
following the procedure described in Subsection (c) above.

                                      -1-
<PAGE>

         (e)  Applicable  Offering  Period.  For  purposes  of  calculating  the
Purchase  Price under  Section 7(b),  the  applicable  Offering  Period shall be
determined as follows:

                  (i) Once a Participant is enrolled in the Plan for an Offering
         Period,  such  Offering  Period  shall  continue to apply to him or her
         until the earliest of (A) the end of such Offering Period,  (B) the end
         of  his  or  her  participation  under  Subsection  (d)  above  or  (C)
         reenrollment  in a  subsequent  Offering  Period under  Paragraph  (ii)
         below.

                  (ii) In the event that the Fair  Market  Value of Stock on the
         last  trading day before the  commencement  of the  Offering  Period in
         which the  Participant  is enrolled is higher than on the last  trading
         day before the  commencement  of any subsequent  Offering  Period,  the
         Participant  shall  automatically  be re-enrolled  for such  subsequent
         Offering Period.

                  (iii) When a Participant reaches the end of an Offering Period
         but his or her  participation  is to  continue,  then such  Participant
         shall  automatically  be  re-enrolled  for  the  Offering  Period  that
         commences immediately after the end of the prior Offering Period.

4.  EMPLOYEE CONTRIBUTIONS.

         (a) Frequency of Payroll Deductions.  A Participant may purchase shares
of  Stock  under  the  Plan  solely  by means  of  payroll  deductions.  Payroll
deductions,  as designated by the Participant  pursuant to Subsection (b) below,
shall occur on each payday during participation in the Plan.

         (b) Amount of Payroll Deductions.  An Eligible Employee shall designate
on the  enrollment  form the portion of his or her  Compensation  that he or she
elects to have withheld for the purchase of Stock. Such portion shall be a whole
percentage  of the Eligible  Employee's  Compensation,  but not less than 1% nor
more than 10%.

         (c) Changing  Withholding  Rate. If a Participant  wishes to change the
rate of payroll withholding, he or she may do so by filing a new enrollment form
with the Company not later than one week prior to the last  working day prior to
the  commencement  of the  Accumulation  Period for which  such  change is to be
effective.

         (d)  Discontinuing  Payroll  Deductions.  If a  Participant  wishes  to
discontinue employee contributions entirely, he or she may do so by filing a new
enrollment  form  at any  time.  Payroll  withholding  shall  cease  as  soon as
reasonably practicable after such form has been received by the Company.

5.  WITHDRAWAL FROM THE PLAN.

         (a)  Withdrawal.  A Participant  may elect to withdraw from the Plan by
filing the  prescribed  form with the Company at any time before the last day of
an Accumulation Period. As soon as reasonably  practicable  thereafter,  payroll
deductions shall cease and the entire amount credited to the Participant's  Plan
Account shall be refunded to him or her in cash,  without  interest.  No partial
withdrawals shall be permitted.

         (b)  Re-Enrollment  After  Withdrawal.  A  former  Participant  who has
withdrawn from the Plan shall not be a Participant until he or she re-enrolls in
the Plan under Section 3(b).

                                      -2-
<PAGE>

6.  TERMINATION OF EMPLOYMENT OR DEATH.

         (a) Termination of Employment. Termination of employment as an Eligible
Employee  for any  reason,  including  death,  shall be treated as an  automatic
withdrawal from the Plan under Section 5(a). (A transfer from one  Participating
Company to another shall not be treated as a termination of employment.)

         (b) Death. In the event of the Participant's death, the amount credited
to his or her Plan Account shall be paid to a  beneficiary  designated by him or
her for this purpose on the  prescribed  form or, if none, to the  Participant's
estate.  Such form shall be valid only if it was filed with the  Company  before
the Participant's death.

7.  PLAN ACCOUNTS AND PURCHASE OF SHARES.

         (a) Plan  Accounts.  The Company  shall  maintain a Plan Account on its
books in the name of each  Participant.  Whenever an amount is deducted from the
Participant's  Compensation under the Plan, such amount shall be credited to the
Participant's Plan Account. No interest shall be credited to Plan Accounts.

         (b)  Purchase  Price.  The  Purchase  Price  for  each  share  of Stock
purchased at the close of an Accumulation Period shall be the lower of:

                  (i) 85% of the Fair  Market  Value  of such  share on the last
         trading day before the  commencement of the applicable  Offering Period
         (as determined under Section 3(e)); or

                  (ii) 85% of the Fair  Market  Value of such  share on the last
         trading day in such Accumulation Period.

         (c) Number of Shares Purchased. As of the last day of each Accumulation
Period,  each Participant shall be deemed to have elected to purchase the number
of shares of Stock calculated in accordance with this Subsection (c), unless the
Participant has previously  elected to withdraw from the Plan in accordance with
Section 5(a). The amount then in the Participant's Plan Account shall be divided
by the Purchase Price,  and the number of shares that results shall be purchased
from the Company with the funds in the Participant's Plan Account. The foregoing
notwithstanding,  no  Participant  shall  purchase  more than a maximum of 2,500
shares of Stock with respect to any  Accumulation  Period nor shares of Stock in
excess of the  amounts  set forth in  Sections 8 and 12(a).  The  Committee  may
determine  with  respect  to all  Participants  that any  fractional  share,  as
calculated  under this  Subsection  (c), shall be rounded down to the next lower
whole share.

         (d)  Available  Shares  Insufficient.  In the event that the  aggregate
number of shares that all Participants  elect to purchase during an Accumulation
Period  exceeds the maximum  number of shares  remaining  available for issuance
under  Section  12(a),  then the number of shares to which each  Participant  is
entitled shall be determined by multiplying  the number of shares  available for
issuance by a fraction, the numerator of which is the number of shares that such
Participant  has elected to purchase and the  denominator of which is the number
of shares that all Participants have elected to purchase.

         (e) Issuance of Stock.  Certificates  representing  the shares of Stock
purchased by a Participant  under the Plan shall be issued to him or her as soon
as reasonably practicable after the close of the applicable Accumulation Period,
except that the Committee may determine  that such shares shall be held for each
Participant's  benefit  by a broker  designated  by the  Committee  (unless  the
Participant has elected that  certificates be issued to him or her).  Shares may
be  registered  in the name of the  Participant  or  jointly  in the name

                                      -3-
<PAGE>

of the  Participant  and his or her  spouse  as  joint  tenants  with  right  of
survivorship or as community property.

         (f) Unused Cash Balances. An amount remaining in the Participant's Plan
Account that  represents the Purchase  Price for any  fractional  share shall be
carried over in the Participant's Plan Account to the next Accumulation  Period.
Any amount  remaining in the  Participant's  Plan Account  that  represents  the
Purchase  Price for  whole  shares  that  could  not be  purchased  by reason of
Subsection  (c) above or Section 12(a) shall be refunded to the  Participant  in
cash, without interest.

8.  LIMITATIONS ON STOCK OWNERSHIP.

         Any other provision of the Plan  notwithstanding,  no Participant shall
be granted a right to purchase Stock under the Plan if:

                  (a) Such Participant, immediately after his or her election to
         purchase  such Stock,  would own stock  possessing  more than 5% of the
         total  combined  voting  power or value of all  classes of stock of the
         Company or any parent or Subsidiary of the Company; or

                  (b) Under the terms of the Plan, such Participant's  rights to
         purchase  stock  under  this and all  other  qualified  employee  stock
         purchase  plans of the  Company  or any  parent  or  Subsidiary  of the
         Company would accrue at a rate that exceeds  $25,000 of the fair market
         value of such stock (determined at the time when such right is granted)
         for each calendar year for which such right or option is outstanding at
         any time.

Ownership of stock shall be determined  after applying the attribution  rules of
section 424(d) of the Internal Revenue Code of 1986, as amended. For purposes of
this Section 8, each Participant shall be considered to own any stock that he or
she has a right or option to  purchase  under this or any other  plan,  and each
Participant  shall be considered  to have the right to purchase  2,500 shares of
Stock under this Plan with respect to each Accumulation Period.

9.  RIGHTS NOT TRANSFERABLE.

         The  rights of any  Participant  under the Plan,  or any  Participant's
interest  in any Stock or moneys  to which he or she may be  entitled  under the
Plan,  shall not be  transferable  by voluntary or involuntary  assignment or by
operation of law, or in any other manner other than by  beneficiary  designation
or the laws of descent and distribution. If a Participant in any manner attempts
to transfer,  assign or otherwise  encumber his or her rights or interest  under
the Plan,  other than by  beneficiary  designation  or the laws of  descent  and
distribution,  then such act shall be treated as an election by the  Participant
to withdraw from the Plan under Section 5(a).

10.  NO RIGHTS AS AN EMPLOYEE.

         Nothing in the Plan shall be  construed to give any person the right to
remain in the employ of a  Participating  Company.  Each  Participating  Company
reserves the right to terminate the  employment of any person at any time,  with
or without cause.

                                      -4-
<PAGE>

11.  NO RIGHTS AS A STOCKHOLDER.

         A Participant shall have no rights as a stockholder with respect to any
shares that he or she has purchased, or may have a right to purchase,  under the
Plan until the date of issuance of a stock certificate for such shares.

12.  STOCK OFFERED UNDER THE PLAN.

         (a)  Authorized  Shares.  The  aggregate  number  of  shares  of  Stock
available  for purchase  under the Plan shall be 100,000,  subject to adjustment
pursuant to this Section 12.

         (b) Anti-Dilution Adjustments.  The aggregate number of shares of Stock
offered under the Plan, the 2,500-share limitation described in Section 7(c) and
the price of shares  that any  Participant  has  elected  to  purchase  shall be
adjusted  proportionately  by the  Committee for any increase or decrease in the
number  of  outstanding   shares  of  Stock  resulting  from  a  subdivision  or
consolidation of shares, the payment of a stock dividend,  any other increase or
decrease in such shares effected  without receipt or payment of consideration by
the Company or the  distribution  of the shares of a Subsidiary to the Company's
stockholders.

         (c)  Reorganizations.  In the event of a dissolution  or liquidation of
the Company,  or a merger or consolidation to which the Company is a constituent
corporation,  the Plan shall terminate unless the plan of merger,  consolidation
or reorganization  provides  otherwise,  and all amounts that have been withheld
but not yet applied to  purchase  Stock  hereunder  shall be  refunded,  without
interest.  The Plan shall in no event be  construed  to  restrict in any way the
Company's right to undertake a dissolution,  liquidation,  merger, consolidation
or other reorganization.

13.  AMENDMENT OR DISCONTINUANCE.

         The  Board of  Directors  shall  have the right to  amend,  suspend  or
terminate the Plan at any time and without notice. Except as provided in Section
12, any increase in the  aggregate  number of shares of Stock to be issued under
the Plan shall be  subject  to  approval  by a vote of the  stockholders  of the
Company.  In  addition,  any other  amendment  of the Plan  shall be  subject to
approval by a vote of the  stockholders of the Company to the extent required by
an applicable law or regulation.

14.  DEFINITIONS.

         (a)  "Accumulation  Period"  means  a  six-month  period  during  which
contributions  may be made  toward  the  purchase  of Stock  under the Plan,  as
determined pursuant to Section 3(b).

         (b) "Board of  Directors"  means the Board of Directors of the Company,
as constituted from time to time.

         (c) "Committee" means a committee of the Board of Directors, consisting
of one or more directors appointed by the Board of Directors.

         (d)  "Company"  means  Neurobiological  Technologies,  Inc., a Delaware
corporation.

         (e)  "Compensation"  means  the  total  compensation  paid in cash to a
Participant by a Participating  Company,  including  salaries,  wages,  bonuses,
incentive  compensation,  com-

                                      -5-
<PAGE>

missions and overtime pay, but excluding  moving or relocation  allowances,  car
allowances,  imputed  income  attributable  to cars or life  insurance,  taxable
fringe benefits and similar items, all as determined by the Committee.

         (f) "Eligible Employee" means any employee of a Participating Company:

                  (i) Whose  customary  employment  is for more than five months
         per calendar year and for more than 20 hours per week; and

                  (ii) Who has been an employee of a  Participating  Company for
         not less than three consecutive months.

         (g)  "Fair  Market  Value"  shall  mean  the  market  price  of  Stock,
determined by the Committee as follows:

                  (i) If  Stock  was  traded  over-the-counter  on the  date  in
         question  but was not traded on the Nasdaq  Stock  Market or the Nasdaq
         National Market,  then the Fair Market Value shall be equal to the mean
         between the last  reported  representative  bid and asked prices quoted
         for such date by the principal automated  inter-dealer quotation system
         on which  Stock is quoted  or,  if the Stock is not  quoted on any such
         system,  by the  "Pink  Sheets"  published  by the  National  Quotation
         Bureau, Inc.;

                  (ii) If  Stock  was  traded  over-the-counter  on the  date in
         question  and was  traded on the  Nasdaq  Stock  Market  or the  Nasdaq
         National  Market,  then the  Fair  Market  Value  shall be equal to the
         last-transaction  price quoted for such date by the Nasdaq Stock Market
         or the Nasdaq National Market;

                  (iii) If the Stock was traded on a stock  exchange on the date
         in  question,  then the Fair Market Value shall be equal to the closing
         price reported by the applicable composite transactions report for such
         date; and

                  (iv) If none of the foregoing  provisions is applicable,  then
         the Fair Market  Value shall be  determined  by the  Committee  in good
         faith on such basis as it deems appropriate.

Whenever possible, the determination of Fair Market Value by the Committee shall
be based on the  prices  reported  in the  Western  Edition  of The Wall  Street
Journal. Such determination shall be conclusive and binding on all persons.

         (h) "Offering Period" means a 24-month period with respect to which the
right to purchase Stock may be granted under the Plan, as determined pursuant to
Section 3(a).

         (i) "Participant"  means an Eligible Employee who elects to participate
in the Plan, as provided in Section 3(c).

         (j)  "Participating  Company"  means the  Company  and each  present or
future Subsidiary, except Subsidiaries excluded by the Committee.

         (k) "Plan" means this Neurobiological Technologies, Inc. Employee Stock
Purchase Plan, as amended from time to time.

         (l) "Plan Account" means the account  established for each  Participant
pursuant to Section 6(a).

                                      -6-
<PAGE>

         (m) "Purchase Price" means the price at which Participants may purchase
Stock under the Plan, as determined pursuant to Section 7(b).

         (n) "Stock" means the Common Stock of the Company.

         (o) "Subsidiary" means a corporation, 50% or more of the total combined
voting  power of all  classes  of stock of which is owned by the  Company  or by
another Subsidiary.

15.  EXECUTION.

         To record the  amendment  and  restatement  of the Plan by the Board of
Directors,  the  Company  has  caused its duly  authorized  officer to affix the
corporate name and seal hereto.


                                         NEUROBIOLOGICAL TECHNOLOGIES,
                                         INC.




                                         By /s/ Shawn K. Johnson
                                            ------------------------------
                                                Director of Finance


                                      -7-


<PAGE>
                                                                      APPENDIX A

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                                     PROXY
          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     The  undersigned  hereby  appoints  Jeffrey  S.  Price  proxy,  and  hereby
authorizes  him to represent and vote as  designated on the other side,  all the
shares of stock of  Neurobiological  Technologies,  Inc. standing in the name of
the undersigned  with all powers which the undersigned  would possess if present
at the Annual  Meeting of  Stockholders  of the Company to be held  November 14,
1996 or any adjournment thereof.

       (Continued, and to be marked, dated and signed, on the other side)


<PAGE>

                                                                Please mark  ---
                                                                 your votes   X
                                                                  as this    ---
                                                   
                                                      WITHHELD
                                                FOR   FOR ALL                  
ITEM 1-ELECTION OF DIRECTORS                    [  ]   [  ]  
       Nominees:                                               
       Jeffrey S. Price  Theodore L. Eliot, Jr                 
       Abraham E. Cohen  Lawrence G. Mohr, Jr                  
       Enoch Gallaway    John B. Stuppin                       
                            
WITHHELD FOR: (Write that nominee's name in the
space provided below.)

- -----------------------------------------------

                      FOR   AGAINST  ABSTAIN
ITEM 2-APPROVAL OF    [  ]   [  ]      [  ]
       AN AMENDMENT
       TO EMPLOYEE
       STOCK
       PURCHASE PLAN

                      FOR   AGAINST  ABSTAIN
ITEM 3-APPOINTMENT    [  ]   [  ]      [  ]
       OF INDEPEN-
       DENT AUDITORS






Signature(s)______________________________________________ Date___________, 1996
Please date and sign exactly as name  appears  hereon.  Joint owners should each
sign. When signing as attorney,  executor,  administrator,  trustee or guardian,
please give full title as such.
- --------------------------------------------------------------------------------

                             -FOLD AND DETACH HERE-




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