NEUROBIOLOGICAL TECHNOLOGIES INC /CA/
S-8, 1998-01-12
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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     As filed with the Securities and Exchange Commission on January 9, 1998
                          Registration No.333-_________

                                  UNITED STATES
                        SECURITY AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                                    FORM S-8

                             REGISTRATION STATEMENT
                                      Under
                           THE SECURITIES ACT OF 1933


                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
        (Exact name of small business issuer as specified in its charter)

         Delaware                                           94-3049219
(State or other jurisdiction of incorporation  (IRS Employer Identification No.)
         or organization)

                              1387 Marina Way South
                           Richmond, California 94804
                    (Address of principal executive offices)

             AMENDED AND RESTATED NEUROBIOLOGICAL TECHNOLOGIES, INC.
                                 1993 STOCK PLAN
                            (Full title of the plan)

                                                              Copy to:
             PAUL E. FREIMAN                              NEIL FLANZRAICH
  President and Chief Executive Officer                 STEPHEN C. FERRUOLO
             Neurobiological                            Heller Ehrman White
            Technologies, Inc                         & McAuliffe, Attorneys
          1387 Marina Way South                        525 University Avenue
        Richmond, California 94804                  Palo Alto, California 94301
              (510) 215-8000                              (650) 624-7000
 (Name and address of agent for service)
<TABLE>
<CAPTION>

                                        CALCULATION OF REGISTRATION FEE
      ------------------- ----------------- ----------------------- ----------------------- ---------------
<S>   <C>                 <C>               <C>                     <C>                     <C>
      Title of            Amount to be      Proposed maximum        Proposed maximum        Amount of
      securities to be    registered        offering price per      aggregate offering      registration
      register                              share (1)               price                   fee
      ------------------- ----------------- ----------------------- ----------------------- ---------------

      Common Stock,
      $ .01 par value     500,000 shares          $.656                  $328,000              $108.24

      ------------------- ----------------- ----------------------- ----------------------- ---------------
<FN>
(1) Pursuant to Rule 457 (h), the  registration fee was computed on the basis of
the market value of the Common Stock,  computed in accordance  with Rule 457 (c)
on the basis of the  average of the high and low prices per share of such Common
Stock as reported on The Nasdaq SmallCap Market on January 7, 1998.
</FN>
</TABLE>
The registration statement shall become effective upon filing in accordance with
Rule 462 under the Securities Act of 1933.


                                       1
<PAGE>



                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

GENERAL INFORMATION

         This  Registration   Statement  is  being  filed  for  the  purpose  of
increasing  the number of shares of Common Stock reserved for issuance under the
1993 Stock  Plan by 500,000  shares to a total of  2,000,000  shares.  This will
increase  the number of  securities  of the same class as other  securities  for
which a Registration  Statement of the  Registration on Form S-8 relating to the
same employee benefit plan is effective.

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE.

         The following  documents  filed by Registrant  with the  Securities and
Exchange   Commission  are  incorporated  by  reference  in  this   Registration
Statement:

         (1)  Registrant's  Form  S-8  Registration  Statements  filed  with the
              Securities  and Exchange  Commission  on February 16 1994 (File No
              33-75392) and on December 20, 1996 (File No. 333-18519).

         (2)  Registrant's  Annual  Report on Form  10-KSB for the  fiscal  year
              ended June 30,  1997,  as  amended,  which  contains,  among other
              things,  the audited  financial  statements of Registrant  for the
              fiscal year ended June 30, 1997,  together with the report thereon
              of Ernst & Young LLP, independent auditors.

         (3)  Registrant's Quarterly Report on Form 10-QSB for the quarter ended
              September 30, 1997.

         (4)  The  description  of   Registrant's   common  stock  contained  in
              Registrant's  Registration  Statement on Form 8-A filed on January
              14, 1994 (File No. 0-23280).

         In addition, all documents subsequently filed by Registrant pursuant to
Section 13 (a), 13 (c), 14 and 15 (d) of the  Securities  Exchange  Act of 1934,
prior to the  filing of a  post-effective  amendment  which  indicates  that all
securities  offered  have been sold or which  deregisters  all  securities  then
remaining  unsold,  shall be  deemed to be  incorporated  by  reference  in this
registration  statement  and to be a part hereof from the date of filing of such
documents.


ITEM 8.  EXHIBITS

Exhibit
Number            Exhibit
- ------            -------

 5.1              Opinion regarding legality of securities to be offered.
10.1              Amended and Restated Neurobiological  Technologies,  Inc. 1993
                  Stock Plan.
23.1              Consent of Ernst & Young LLP, Independent Auditors.
23.2              Consent  of  Heller   Ehrman  White  &  McAuliffe,   Attorneys
                  (included in Exhibit 5.1).
24.1              Power of Attorney

                                       2

<PAGE>


SIGNATURES

         Pursuant to the  requirements  of the  Securities  and  Exchange Act of
1933, the registrant certifies that it has reasonable grounds to believe that it
meets all of the  requirements  for filing on Form S-8, and has duly caused this
registration statement to be signed on its behalf by the undersigned,  thereunto
duly  authorized,  in the City of Richmond,  State of California,  on January 9,
1998.



                                              NEUROBIOLOGICAL TECHNOLOGIES, INC.

                                     By       /s/ Paul E. Freiman
                                              -------------------
                                              Paul E. Freiman
                                              President, Chief Executive Officer

                                                                     EXHIBIT 5.1


                                 January 8, 1998


                                                                      23855-0001

Via Federal Express

Neurobiological Technologies, Inc.
1387 Marina Way South
Richmond, California  94804

         Re: Registration Statement on Form S-8

Dear  Ladies and Gentlemen:

         We have acted as  counsel  to  Neurobiological  Technologies,  Inc.,  a
Delaware  corporation  (the  "Company"),  in  connection  with the  Registration
Statement on Form S-8 (the "Registration  Statement") which the Company proposes
to file with the Securities  and Exchange  Commission on January 9, 1997 for the
purpose  of  registering  under  the  Securities  Act of 1933,  as  amended,  an
additional  500,000 shares of its Common Stock,  par value $.01 (the  "Shares").
The Shares are issuable under the Company's 1993 Stock Plan (the "Plan").

         We  have  assumed  the  authenticity  of  all  records,  documents  and
instruments submitted to us as originals, the genuineness of all signatures, the
legal  capacity of natural  persons and the  conformity  to the originals of all
records, documents and instruments submitted to us as copies.

         In rendering  our opinion,  we have  examined  the  following  records,
documents and instruments:

     (a) The  Certificate  of  Incorporation  of the  Company,  certified by the
         Delaware  Secretary of State as of December 12, 1997,  and certified to
         us by an officer of the Company as being  complete and in full force as
         of the date of this opinion;

     (b) The Bylaws of the Company  certified to us by an officer of the Company
         as being  complete  and in full force and effect as of the date of this
         opinion;


<PAGE>

Neurobiological Technologies, Inc.               Heller Ehrman White & McAuliffe
January 8, 1998                                                        ATTORNEYS
Page 2

     (c) A  Certificate  of an  officer of the  Company  (i)  attaching  records
         certified to us as constituting  all records of proceedings and actions
         of the  Board  of  Directors,  including  any  committee  thereof,  and
         stockholders   of  the  Company   relating  to  the  Shares,   and  the
         Registration  Statement,  and (ii)  certifying  as to  certain  factual
         matters;

     (d) The Registration Statement;

     (d) The Plan; and

     (e) A letter from  ChaseMellon  Shareholder  Services,  LLC, the  Company's
         transfer  agent,  dated  January 6, 1998, as to the number of shares of
         the Company's common stock that were outstanding on December 12, 1997.

         This  opinion  is limited to the  federal  law of the United  States of
America  and the  General  Corporation  Law of the  State  of  Delaware,  and we
disclaim  any  opinion  as to the laws of any  other  jurisdiction.  We  further
disclaim any opinion as to any other statute, rule, regulation, ordinance, order
or  other  promulgation  of any  other  jurisdiction  or any  regional  or local
governmental body or as to any related judicial or administrative opinion.

         Based upon the foregoing and our  examination  of such questions of law
as we have deemed necessary or appropriate for the purpose of this opinion,  and
assuming  that (i) the  Registration  Statement  becomes and  remains  effective
during  the  period  when the  Shares  are  offered  and  issued,  (ii) the full
consideration  stated  in the  Plan  is  paid  for  each  Share  and  that  such
consideration  in respect of each Share includes payment of cash or other lawful
consideration  at  least  equal  to the par  value  thereof,  (iii)  appropriate
certificates  evidencing  the Shares are executed and  delivered by the Company,
and (iv) all  applicable  securities  laws are complied  with, it is our opinion
that when issued and sold by the Company,  after payment therefore in the manner
provided in the Plan and the Registration Statement,  the Shares will be legally
issued, fully paid and nonassessable.

         This  opinion is rendered to you in  connection  with the  Registration
Statement and is solely for your benefit. This opinion may not be relied upon by
you for any other purpose, or relied upon by any other person, firm, corporation
or other entity for any purpose,  without our prior written consent. We disclaim
any  obligation to advise you of any change of law that occurs,  or any facts of
which we may become aware, after the date of this opinion.


<PAGE>

Neurobiological Technologies, Inc.               Heller Ehrman White & McAuliffe
January 8, 1998                                                        ATTORNEYS
Page 3

         We hereby  consent to the  filing of this  opinion as an exhibit to the
Registration Statement.



                                                     Very truly yours,


                                                                    EXHIBIT 10.1


                              AMENDED AND RESTATED
                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                                 1993 STOCK PLAN


SECTION 1.  ESTABLISHMENT AND PURPOSE.


         The 1993 Stock Plan of Neurobiological  Technologies,  Inc. was adopted
by the  Company's  Board of Directors on November 18, 1993 and was  subsequently
amended and restated, with stockholder approval, effective February 15, 1994. In
September  1994,  the Board of  Directors  again  amended the 1993 Stock Plan of
Neurobiological   Technologies,   Inc.,  with  stockholder  approval,  effective
November 16, 1994. The 1993 Stock Plan of Neurobiological Technologies, Inc. was
subsequently  amended and restated by the Board of Directors in September,  1997
and approved by the stockholders on November 4, 1997.

         Its purpose is to offer directors and selected employees,  advisors and
consultants an  opportunity to acquire a proprietary  interest in the success of
the Company, or to increase such interest, by purchasing Shares of the Company's
Common Stock.  The Plan provides both for the direct award or sale of Shares and
for the grant of Options to purchase Shares.  Options granted under the Plan may
include  Nonstatutory  Options as well as Incentive  Stock  Options  intended to
qualify under section 422 of the Code.

         The Plan is intended to comply in all respects  with Rule 16b-3 (or its
successor) under the Exchange Act and shall be construed accordingly.

SECTION 2.  DEFINITIONS.

         (a)  "Board of  Directors"  shall  mean the Board of  Directors  of the
         Company, as constituted from time to time.

         (b)  "Change in  Control"  shall mean the  occurrence  of either of the
         following events:

                  (i) A change in the composition of the Board of Directors,  as
                  a  result  of  which  fewer  than  one-half  of the  incumbent
                  directors are directors who either:

                           (A) Had been directors of the Company 24 months prior
                           to such change; or

                           (B) Were elected,  or nominated for election,  to the
                           Board of Directors with the  affirmative  votes of at
                           least  a  majority  of the  directors  who  had  been
                           directors  of the  Company  24  months  prior to such
                           change  and who were  still in  office at the time of
                           the election or nomination; or


                  (ii) Any "person" (as such term is used in sections  13(d) and
                  14(d) of the Exchange Act) by the  acquisition  or aggregation
                  of securities is or becomes the beneficial owner,  directly or
                  indirectly,  of  securities  of the  Company  representing  30
                  percent or more of the combined  voting power of the Company's
                  then outstanding  securities ordinarily (and apart from rights
                  accruing under special circumstances) having the right to vote
                  at elections of directors (the "Base Capital  Stock");  except
                  that any change in the  relative  beneficial  ownership of the
                  Company's  securities  by any person  resulting  solely from a
                  reduction in the  aggregate  number of  outstanding  shares of
                  Base  Capital  Stock,  and  any  decrease  thereafter  in such
                  person's  ownership of securities,  shall be disregarded until
                  such person  increases in any manner,  directly or indirectly,
                  such person's  beneficial  ownership of any  securities of the
                  Company.



                                      4
<PAGE>


         (c)  "Code" shall mean the Internal Revenue Code of 1986, as amended.

         (d)  "Committee"  shall mean a committee of the Board of Directors,  as
         described in Section 3(a).

         (e) "Company" shall mean Neurobiological Technologies, Inc., a Delaware
         corporation.

         (f)  "Employee"  shall  mean  (i) any  individual  who is a  common-law
         employee of the Company or of a  Subsidiary,  (ii) an Outside  Director
         and (iii) an  independent  contractor  who  performs  services  for the
         Company  or a  Subsidiary  and  who is not a  member  of the  Board  of
         Directors.

         (g) "Exchange Act" shall mean the  Securities  Exchange Act of 1934, as
         amended.

         (h)  "Exercise  Price" shall mean the amount for which one Share may be
         purchased upon exercise of an Option,  as specified by the Committee in
         the applicable Stock Option Agreement.

         (i)  "Fair  Market  Value"  shall  mean  the  market  price  of  Stock,
         determined by the Committee as follows:

                  (i) If  Stock  was  traded  over-the-counter  on the  date  in
                  question  but was not traded on the Nasdaq Stock Market or the
                  Nasdaq  National  Market,  then the Fair Market Value shall be
                  equal to the mean between the last reported representative bid
                  and  asked  prices  quoted  for  such  date  by the  principal
                  automated  inter-dealer  quotation  system  on which  Stock is
                  quoted or, if the Stock is not quoted on any such  system,  by
                  the "Pink Sheets" published by the National  Quotation Bureau,
                  Inc.;

                  (ii) If  Stock  was  traded  over-the-counter  on the  date in
                  question  and was  traded on the  Nasdaq  Stock  Market or the
                  Nasdaq  National  Market,  then the Fair Market Value shall be
                  equal to the  last-transaction  price  quoted for such date by
                  the Nasdaq Stock Market or the Nasdaq National Market;

                  (iii) If Stock was traded on a stock  exchange  on the date in
                  question,  then the Fair  Market  Value  shall be equal to the
                  closing     price      reported     by     the      applicable
                  composite-transactions report for such date; and

                  (iv) If none of the foregoing  provisions is applicable,  then
                  the Fair Market Value shall be  determined by the Committee in
                  good faith on such basis as it deems appropriate.

                  Whenever  possible,  the determination of Fair Market Value by
                  the  Committee  shall be based on the prices  reported  in the
                  Western Edition of The Wall Street Journal. Such determination
                  shall be conclusive and binding on all persons.

         (j) "ISO" shall mean an employee  incentive  stock option  described in
         section 422(b) of the Code.

         (k)  "Nonstatutory  Option"  shall mean a stock option not described in
         sections 422(b) or 423(b) of the Code.

         (l)  "Offeree"  shall  mean an  individual  to whom the  Committee  has
         offered  the right to acquire  Shares  under the Plan  (other than upon
         exercise of an Option).

         (m) "Option" shall mean an ISO or Nonstatutory Option granted under the
         Plan and entitling the holder to purchase Shares.

         (n)  "Optionee" shall mean an individual who holds an Option.

         (o)  "Outside  Director"  shall mean a member of the Board of Directors
         who is not a common-law employee of the Company or of a Subsidiary.

         (p)  "Plan"  shall  mean  this  1993  Stock  Plan  of   Neurobiological
         Technologies, Inc., as amended from time to time.


                                       5

<PAGE>


         (q) "Purchase Price" shall mean the  consideration  for which one Share
         may be acquired under the Plan (other than upon exercise of an Option),
         as specified by the Committee.

         (r)  "Service" shall mean service as an Employee.

         (s) "Share"  shall mean one share of Stock,  as adjusted in  accordance
         with Section 9 (if applicable).

         (t)  "Stock" shall mean the Common Stock of the Company.

         (u) "Stock  Option  Agreement"  shall mean the  agreement  between  the
         Company  and an  Optionee  which  contains  the terms,  conditions  and
         restrictions pertaining to his or her Option.

         (v) "Stock  Purchase  Agreement"  shall mean the agreement  between the
         Company  and an  Offeree  who  acquires  Shares  under  the Plan  which
         contains  the terms,  conditions  and  restrictions  pertaining  to the
         acquisition of such Shares.

         (w) "Subsidiary" shall mean any corporation,  if the Company and/or one
         or more  other  Subsidiaries  own not less than 50 percent of the total
         combined  voting  power of all  classes  of  outstanding  stock of such
         corporation. A corporation that attains the status of a Subsidiary on a
         date after the  adoption of the Plan shall be  considered  a Subsidiary
         commencing as of such date.

         (x) "Total and  Permanent  Disability"  shall mean that the Optionee is
         unable to engage in any substantial  gainful  activity by reason of any
         medically  determinable  physical  or  mental  impairment  which can be
         expected to result in death or which has lasted,  or can be expected to
         last, for a continuous period of not less than one year.

SECTION 3.  ADMINISTRATION.

         (a)  Committee  Membership.  The  Plan  shall  be  administered  by the
         Committee.  The Committee  shall  consist of two or more  disinterested
         directors of the Company and shall meet such other  requirements as may
         be  established  from  time  to  time by the  Securities  and  Exchange
         Commission for plans intended to qualify for exemption under Rule 16b-3
         (or its  successor)  under the Exchange Act. The Board of Directors may
         appoint a separate committee of the Board of Directors, composed of one
         or  more  directors  of the  Company  who  need  not  be  disinterested
         directors,  who may  administer  the Plan with respect to Employees who
         are not  officers or  directors  of the  Company,  may grant Shares and
         Options under the Plan to such  Employees and may determine the timing,
         number of Shares and other terms of such grants.

         (b) Disinterested  Directors.  A member of the Board of Directors shall
         be deemed "disinterested" only if he or she satisfies:

                  (i)  Such   requirements   as  the   Securities  and  Exchange
                  Commission may establish for  disinterested  administrators of
                  plans  designed to qualify for exemption  under Rule 16b-3 (or
                  its successor) under the Exchange Act; and

                  (ii) Such  requirements  as the Internal  Revenue  Service may
                  establish for outside directors acting under plans intended to
                  qualify for exemption under section 162(m)(4)(C) of the Code.

                  An  Outside  Director  shall  not  fail to be  "disinterested"
                  solely  because he or she  receives the  Nonstatutory  Options
                  described in Section 4(b).

         (c)  Committee  Procedures.  The Committee  shall  designate one of its
         members as chairman.  The Committee may hold meetings at such times and
         places as it shall  determine.  The acts of a majority of the Committee
         members  present at meetings at which a quorum exists,  or acts reduced
         to or approved in writing by all Committee members, shall be valid acts
         of the Committee.

         (d) Committee Responsibilities.  Subject to the provisions of the Plan,
         the  Committee  shall have full  authority  and  discretion to take the
         following actions:


                                       6

<PAGE>


                  (i) To interpret the Plan and to apply its provisions;

                  (ii) To adopt,  amend or rescind  rules,  procedures and forms
                  relating to the Plan;

                  (iii) To  authorize  any person to  execute,  on behalf of the
                  Company,  any instrument required to carry out the purposes of
                  the Plan;

                  (iv) To determine when Shares are to be awarded or offered for
                  sale and when Options are to be granted under the Plan;

                  (v) To select the Offerees and Optionees;

                  (vi) To  determine  the number of Shares to be offered to each
                  Offeree or to be made subject to each Option;

                  (vii) To prescribe  the terms and  conditions of each award or
                  sale of Shares,  including  (without  limitation) the Purchase
                  Price,  and to specify the  provisions  of the Stock  Purchase
                  Agreement relating to such award or sale;

                  (viii) To prescribe  the terms and  conditions of each Option,
                  including   (without   limitation)   the  Exercise  Price,  to
                  determine whether such Option is to be classified as an ISO or
                  as a Nonstatutory Option, and to specify the provisions of the
                  Stock Option Agreement relating to such Option;

                  (ix) To amend any  outstanding  Stock  Purchase  Agreement  or
                  Stock   Option   Agreement,   subject  to   applicable   legal
                  restrictions and to the consent of the Offeree or Optionee who
                  entered into such agreement;

                  (x) To  prescribe  the  consideration  for the  grant  of each
                  Option  or other  right  under the Plan and to  determine  the
                  sufficiency of such consideration; and

                  (xi) To take any other actions  deemed  necessary or advisable
                  for the administration of the Plan.

All decisions, interpretations and other actions of the Committee shall be final
and binding on all  Offerees,  all  Optionees,  and all persons  deriving  their
rights from an Offeree or Optionee.  No member of the Committee  shall be liable
for any action that he or she has taken or has failed to take in good faith with
respect to the Plan, any Option, or any right to acquire Shares under the Plan.

SECTION 4.  ELIGIBILITY.

         (a) General  Rules.  Only  Employees  (including,  without  limitation,
         independent contractors) shall be eligible for designation as Optionees
         or Offerees by the  Committee.  In  addition,  only  Employees  who are
         common-law  employees of the Company or a Subsidiary  shall be eligible
         for the grant of ISOs.

         (b) Outside Directors. Any other provision of the Plan notwithstanding,
         the  participation of Outside Directors in the Plan shall be subject to
         the following restrictions:

                  (i) An  Outside  Director  who  first  becomes a member of the
                  Board of Directors  after  February 15, 1994,  shall receive a
                  one-time grant of a Nonstatutory Option (subject to adjustment
                  under Section 9). Such Nonstatutory Option shall be granted on
                  the date when such Outside  Director  first joins the Board of
                  Directors. The foregoing notwithstanding,  no grant under this
                  Paragraph (i) shall be made to a new Outside Director if he or
                  she replaces a former Outside  Director and the new and former
                  Outside Directors are both affiliated with the same investment
                  fund or similar entity.

                  (ii) Upon the conclusion of each regular annual meeting of the
                  Company's   stockholders,   each  Outside  Director  who  will
                  continue  serving  as a  member  of  the  Board  of  Directors
                  thereafter shall receive a Nonstatutory  Option covering 1,000
                  Shares  (subject to  adjustment  under Section 9),


                                       7
<PAGE>

                  except that such  Nonstatutory  Option shall not be granted in
                  the calendar year in which the same Outside Director  received
                  a Nonstatutory Option described in Paragraph (i) above.

                  (iii) All Nonstatutory  Options granted to an Outside Director
                  under this Subsection (b) shall become  exercisable in full on
                  the  first   anniversary  of  the  date  of  grant.  All  such
                  Nonstatutory  Options shall also become exercisable in full in
                  the event of (A) a Change in Control or (B) the termination of
                  the Outside  Director's  service  because of death,  Total and
                  Permanent Disability or retirement at or after age 65.

                  (iv) The Exercise Price under all Nonstatutory Options granted
                  to an  Outside  Director  under this  Subsection  (b) shall be
                  equal to 100  percent of the Fair  Market  Value of a Share on
                  the date of grant,  payable in one of the forms  described  in
                  Subsection (a), (b), (c) or (d) of Section 8.

                  (v) All  Nonstatutory  Options granted to an Outside  Director
                  under this  Subsection (b) shall  terminate on the earliest of
                  (A) the 10th  anniversary  of the date of grant,  (B) the date
                  three months after the termination of such Outside  Director's
                  service for any reason other than death or Total and Permanent
                  Disability or (C) the date 12 months after the  termination of
                  such Outside  Director's service because of death or Total and
                  Permanent Disability.

                  (vi) A Nonstatutory  Option grant to an Outside Director under
                  this Subsection (b) shall be invalid if such Outside  Director
                  declines  to  execute a Stock  Option  Agreement  pursuant  to
                  Section 7(a).

The Committee may provide that the Nonstatutory  Options that otherwise would be
granted  to an  Outside  Director  under this  Subsection  (b) shall  instead be
granted to an affiliate of such Outside  Director.  Such affiliate shall then be
deemed to be an Outside  Director  for purposes of the Plan,  provided  that the
service-related   vesting  and   termination   provisions   pertaining   to  the
Nonstatutory  Options shall be applied with regard to the service of the Outside
Director.

         (c) Ten-Percent Stockholders. An Employee who owns more than 10 percent
         of the total combined voting power of all classes of outstanding  stock
         of the Company or any of its Subsidiaries shall not be eligible for the
         grant of an ISO unless (i) the  Exercise  Price is at least 110 percent
         of the Fair Market  Value of a Share on the date of grant and (ii) such
         ISO by its terms is not exercisable  after the expiration of five years
         from the date of grant.

         (d)  Attribution  Rules.  For  purposes  of  Subsection  (c) above,  in
         determining  stock  ownership,  an Employee  shall be deemed to own the
         stock  owned,  directly  or  indirectly,  by  or  for  such  Employee's
         brothers,  sisters,  spouse,  ancestors and lineal  descendants.  Stock
         owned,  directly or indirectly,  by or for a corporation,  partnership,
         estate or trust shall be deemed to be owned  proportionately  by or for
         its  stockholders,  partners or  beneficiaries.  Stock with  respect to
         which such Employee holds an option shall not be counted.

         (e)   Outstanding   Stock.   For  purposes  of  Subsection  (c)  above,
         "outstanding  stock"  shall  include  all  stock  actually  issued  and
         outstanding immediately after the grant.  "Outstanding stock" shall not
         include shares authorized for issuance under  outstanding  options held
         by the Employee or by any other person.

SECTION 5.  STOCK SUBJECT TO PLAN.

         (a) Basic Limitation. Shares offered under the Plan shall be authorized
         but unissued Shares or treasury Shares.  The aggregate number of Shares
         which is  issued  under the Plan to all  Employees  (upon  exercise  of
         Options or other rights to acquire  Shares) shall not exceed  2,000,000
         Shares,  subject  to  adjustment  pursuant  to Section 9. The number of
         Shares which are subject to Options or other rights  outstanding at any
         time under the Plan  shall not  exceed the number of Shares  which then
         remain  available for issuance under the Plan. The Company,  during the
         term of the  Plan,  shall  at all  times  reserve  and  keep  available
         sufficient Shares to satisfy the requirements of the Plan.

         (b)  Additional  Shares.  In the event that any  outstanding  Option or
         other  right  for any  reason  expires  or is  cancelled  or  otherwise
         terminated,  the Shares  allocable to the  unexercised  portion of such
         Option or other right shall again be available  for the purposes of the
         Plan. In the event that Shares issued under the Plan are


                                       8
<PAGE>

         reacquired by the Company pursuant to a forfeiture  provision,  a right
         of repurchase or a right of first  refusal,  such Shares shall again be
         available for the purposes of the Plan.

SECTION 6.  TERMS AND CONDITIONS OF AWARDS OR SALES.

         (a) Stock  Purchase  Agreement.  Each award or sale of Shares under the
         Plan (other than upon  exercise of an Option)  shall be  evidenced by a
         Stock  Purchase  Agreement  between the Offeree and the  Company.  Such
         award or sale shall be subject to all  applicable  terms and conditions
         of the Plan and may be subject to any other terms and conditions  which
         are not  inconsistent  with the  Plan and  which  the  Committee  deems
         appropriate for inclusion in a Stock Purchase Agreement. The provisions
         of the various Stock  Purchase  Agreements  entered into under the Plan
         need not be identical.

         (b) Duration of Offers and  Nontransferability  of Rights. Any right to
         acquire   Shares   under  the  Plan  (other   than  an  Option)   shall
         automatically  expire if not  exercised  by the Offeree  within 30 days
         after the grant of such right was  communicated  to the  Offeree by the
         Committee.   Such  right  shall  not  be  transferable   and  shall  be
         exercisable only by the Offeree to whom such right was granted.

         (c) Purchase  Price.  The Purchase  Price of Shares to be offered under
         the Plan shall not be less than the par value of such  Shares.  Subject
         to the preceding  sentence,  the Purchase  Price shall be determined by
         the  Committee  at its sole  discretion.  The  Purchase  Price shall be
         payable in a form described in Section 8.

         (d) Withholding  Taxes. As a condition to the award, sale or vesting of
         Shares,  the Offeree shall make such  arrangements as the Committee may
         require for the  satisfaction of any federal,  state,  local or foreign
         withholding tax obligations  that arise in connection with such Shares.
         The  Committee  may permit the Offeree to satisfy all or part of his or
         her tax  obligations  related  to such  Shares  by having  the  Company
         withhold a portion of any Shares that otherwise  would be issued to him
         or her or by  surrendering  any Shares that previously were acquired by
         him or her. The Shares withheld or surrendered shall be valued at their
         Fair Market Value on the date when taxes otherwise would be withheld in
         cash.  The  payment of taxes by  assigning  Shares to the  Company,  if
         permitted by the Committee,  shall be subject to such  restrictions  as
         the Committee may impose,  including any restrictions required by rules
         of the Securities and Exchange Commission.

         (e)  Restrictions  on  Transfer of Shares.  Any Shares  awarded or sold
         under the Plan shall be subject to such special forfeiture  conditions,
         rights of  repurchase,  rights  of first  refusal  and  other  transfer
         restrictions as the Committee may determine. Such restrictions shall be
         set forth in the applicable Stock Purchase Agreement and shall apply in
         addition to any general  restrictions  that may apply to all holders of
         Shares.

SECTION 7.  TERMS AND CONDITIONS OF OPTIONS.

         (a) Stock  Option  Agreement.  Each  grant of an Option  under the Plan
         shall be evidenced by a Stock Option Agreement executed by the Optionee
         and the Company.  Such Option shall be subject to all applicable  terms
         and  conditions  of the Plan and may be subject to any other  terms and
         conditions  which  are not  inconsistent  with the Plan and  which  the
         Committee deems  appropriate for inclusion in a Stock Option Agreement.
         The  provisions  of the various  Stock Option  Agreements  entered into
         under the Plan need not be identical.

         (b) Number of Shares.  Each Stock Option  Agreement  shall  specify the
         number of Shares that are  subject to the Option and shall  provide for
         the  adjustment of such number in accordance  with Section 9. The Stock
         Option  Agreement  shall also specify whether the Option is an ISO or a
         Nonstatutory Option. Options granted to any Optionee in a single fiscal
         year  shall in no event  cover  more than  250,000  Shares,  subject to
         adjustment in accordance with Section 9.

         (c) Exercise  Price.  Each Stock  Option  Agreement  shall  specify the
         Exercise Price. The Exercise Price of an ISO shall not be less than 100
         percent  of the Fair  Market  Value  of a Share  on the date of  grant,
         except as otherwise  provided in Section 4(c).  The Exercise Price of a
         Nonstatutory  Option  shall  not be less than the par value of a Share.
         Subject to the preceding two  sentences,  the Exercise  Price under any
         Option shall be 


                                       9
<PAGE>

         determined by the Committee at its sole discretion.  The Exercise Price
         shall be payable in a form described in Section 8.

         (d) Withholding Taxes. As a condition to the exercise of an Option, the
         Optionee shall make such  arrangements as the Committee may require for
         the satisfaction of any federal,  state,  local or foreign  withholding
         tax  obligations  that  arise in  connection  with such  exercise.  The
         Optionee shall also make such arrangements as the Committee may require
         for  the  satisfaction  of  any  federal,   state,   local  or  foreign
         withholding  tax  obligations  that may  arise in  connection  with the
         disposition of Shares  acquired by exercising an Option.  The Committee
         may  permit  the  Optionee  to  satisfy  all or  part of his or her tax
         obligations  related  to the Option by having  the  Company  withhold a
         portion of any Shares that  otherwise  would be issued to him or her or
         by surrendering any Shares that previously were acquired by him or her.
         Such Shares shall be valued at their Fair Market Value on the date when
         taxes  otherwise  would be  withheld  in cash.  The payment of taxes by
         assigning Shares to the Company,  if permitted by the Committee,  shall
         be subject to such restrictions as the Committee may impose,  including
         any  restrictions  required  by rules of the  Securities  and  Exchange
         Commission.

         (e) Exercisability.  Each Stock Option Agreement shall specify the date
         when all or any installment of the Option is to become exercisable. The
         vesting of any Option shall be  determined by the Committee at its sole
         discretion.  A Stock  Option  Agreement  may  provide  for  accelerated
         exercisability in the event of a Change in Control, in the event of the
         Optionee's death, Total and Permanent  Disability or retirement or upon
         other events.

         (f) Term.  Each Stock Option  Agreement  shall  specify the term of the
         Option.  The term of an ISO shall not  exceed 10 years from the date of
         grant,  except as otherwise  provided in Section  4(c).  Subject to the
         preceding  sentence,   the  Committee  at  its  sole  discretion  shall
         determine  when an Option is to expire.  A Stock Option  Agreement  may
         provide  that the Option will expire  before the end of its normal term
         in the event that the Optionee's Service terminates.

         (g) Nontransferability.  During an Optionee's lifetime, such Optionee's
         Option(s)  shall be  exercisable  only by him or her and  shall  not be
         transferable.  In the event of an  Optionee's  death,  such  Optionee's
         Option(s)  shall not be  transferable  other  than by will,  by written
         beneficiary designation or by the laws of descent and distribution.

         (h) No Rights as a  Stockholder.  An Optionee,  or a  transferee  of an
         Optionee,  shall have no rights as a  stockholder  with  respect to any
         Shares covered by his or her Option until the date of the issuance of a
         stock certificate for such Shares. No adjustments shall be made, except
         as provided in Section 9.

         (i)  Modification,   Extension  and  Renewal  of  Options.  Within  the
         limitations  of the Plan,  the  Committee  may modify,  extend or renew
         outstanding  Options  or may  accept the  cancellation  of  outstanding
         Options  (to the extent  not  previously  exercised)  in return for the
         grant of new Options at the same or a different  price.  The  foregoing
         notwithstanding,  no  modification  of an  Option  shall,  without  the
         consent of the Optionee,  impair such Optionee's rights or increase his
         or her obligations under such Option.

         (j) Restrictions on Transfer of Shares. Any Shares issued upon exercise
         of an Option  may be  subject to such  special  forfeiture  conditions,
         rights of  repurchase,  rights  of first  refusal  and  other  transfer
         restrictions as the Committee may determine. Such restrictions shall be
         set forth in the applicable  Stock Option  Agreement and shall apply in
         addition to any general  restrictions  that may apply to all holders of
         Shares.

SECTION 8.  PAYMENT FOR SHARES.

         (a) General Rule. The entire Purchase Price or Exercise Price of Shares
         issued  under the Plan shall be  payable in lawful  money of the United
         States of America at the time when such Shares are purchased, except as
         follows:

                  (i) In the case of  Shares  sold  under  the  terms of a Stock
                  Purchase  Agreement subject to the Plan, payment shall be made
                  only pursuant to the express provisions of such Stock Purchase
                  Agreement.


                                       10
<PAGE>

                  However, the Committee (at its sole discretion) may specify in
                  the Stock  Purchase  Agreement that payment may be made in one
                  or both of the  forms  described  in  Subsections  (e) and (f)
                  below.

                  (ii) In the case of an ISO  granted  under the  Plan,  payment
                  shall be made only  pursuant to the express  provisions of the
                  applicable Stock Option Agreement.  However, the Committee (at
                  its sole discretion) may specify in the Stock Option Agreement
                  that payment may be made pursuant to Subsections (b), (c), (d)
                  or (f) below.

                  (iii) In the case of a  Nonstatutory  Option granted under the
                  Plan,  the  Committee  (at its  sole  discretion)  may  accept
                  payment pursuant to Subsections (b), (c), (d) or (f) below.

         (b)  Surrender  of Stock.  To the extent  that this  Subsection  (b) is
         applicable,  payment may be made all or in part with Shares  which have
         already  been owned by the  Optionee or his or her  representative  for
         more than 12 months and which are  surrendered  to the  Company in good
         form for  transfer.  Such  Shares  shall be valued at their Fair Market
         Value on the date when the new Shares are purchased under the Plan.

         (c)   Exercise/Sale.   To  the  extent  that  this  Subsection  (c)  is
         applicable,  payment may be made by the delivery (on a form  prescribed
         by the Company) of an  irrevocable  direction  to a  securities  broker
         approved  by the  Company to sell  Shares and to deliver all or part of
         the sales  proceeds  to the  Company  in  payment of all or part of the
         Exercise Price and any withholding taxes.

         (d)  Exercise/Pledge.  To  the  extent  that  this  Subsection  (d)  is
         applicable,  payment may be made by the delivery (on a form  prescribed
         by the  Company)  of an  irrevocable  direction  to pledge  Shares to a
         securities broker or lender approved by the Company,  as security for a
         loan, and to deliver all or part of the loan proceeds to the Company in
         payment of all or part of the Exercise Price and any withholding taxes.

         (e)  Services  Rendered.  To the  extent  that this  Subsection  (e) is
         applicable,  Shares may be awarded under the Plan in  consideration  of
         services rendered to the Company or a Subsidiary prior to the award. If
         Shares are awarded without the payment of a Purchase Price in cash, the
         Committee shall make a determination  (at the time of the award) of the
         value of the services  rendered by the Offeree and the  sufficiency  of
         the consideration to meet the requirements of Section 6(c).

         (f)  Promissory  Note.  To  the  extent  that  this  Subsection  (f) is
         applicable,  a portion of the Purchase Price or Exercise  Price, as the
         case may be,  of  Shares  issued  under  the Plan may be  payable  by a
         full-recourse  promissory note, provided that (i) the par value of such
         Shares must be paid in lawful money of the United  States of America at
         the time when such Shares are  purchased,  (ii) the Shares are security
         for payment of the principal amount of the promissory note and interest
         thereon  and (iii) the  interest  rate  payable  under the terms of the
         promissory  note  shall  be no less  than  the  minimum  rate  (if any)
         required to avoid the imputation of additional interest under the Code.
         Subject to the foregoing,  the Committee (at its sole discretion) shall
         specify the term, interest rate, amortization requirements (if any) and
         other provisions of such note.

SECTION 9.  ADJUSTMENT OF SHARES.

         (a) General.  In the event of a subdivision of the outstanding Stock, a
         declaration  of a  dividend  payable  in  Shares,  a  declaration  of a
         dividend  payable in a form other than  Shares in an amount  that has a
         material effect on the value of Shares,  a combination or consolidation
         of the  outstanding  Stock (by  reclassification  or otherwise)  into a
         lesser  number of Shares,  a  recapitalization,  a spinoff or a similar
         occurrence,  the Committee shall make appropriate adjustments in one or
         more of (i) the number of Shares  available  under Section 5 for future
         grants to all Employees,  (ii) the number of Nonstatutory Options to be
         granted to Outside  Directors  under Section 4(b),  (iii) the number of
         Shares  covered by each  outstanding  Option or (iv) the Exercise Price
         under each outstanding Option.

         (b)  Reorganizations.  In the event  that the  Company  is a party to a
         merger or other reorganization, outstanding Options shall be subject to
         the agreement of merger or reorganization.  Such agreement may provide,
         without  limitation,  for the assumption of outstanding  Options by the
         surviving  corporation  or its parent,  for their  continuation  by the
         Company (if the Company is a surviving  corporation),  for payment of a
         cash settlement  equal to the difference  between the amount to be paid
         for one Share under such agreement


                                       11
<PAGE>

         and the Exercise Price, or for the acceleration of their exercisability
         followed by the  cancellation  of Options not  exercised,  in all cases
         without the Optionees' consent.  Any cancellation shall not occur until
         after such  acceleration  is effective and Optionees have been notified
         of such acceleration. In the case of Options that have been outstanding
         for less than 12 months,  a  cancellation  need not be  preceded  by an
         acceleration.

         (c)  Reservation  of Rights.  Except as provided in this  Section 9, an
         Optionee or Offeree  shall have no rights by reason of any  subdivision
         or  consolidation  of shares of stock of any class,  the payment of any
         dividend  or any other  increase or decrease in the number of shares of
         stock of any class.  Any issue by the Company of shares of stock of any
         class,  or  securities  convertible  into shares of stock of any class,
         shall not affect,  and no  adjustment  by reason  thereof shall be made
         with respect to, the number or Exercise  Price of Shares  subject to an
         Option. The grant of an Option pursuant to the Plan shall not affect in
         any way  the  right  or  power  of the  Company  to  make  adjustments,
         reclassifications,   reorganizations  or  changes  of  its  capital  or
         business structure, to merge or consolidate or to dissolve,  liquidate,
         sell or transfer all or any part of its business or assets.

SECTION 10.  SECURITIES LAWS.

         Shares  shall not be issued  under the Plan  unless  the  issuance  and
delivery  of such  Shares  complies  with (or is  exempt  from)  all  applicable
requirements of law, including (without  limitation) the Securities Act of 1933,
as amended, the rules and regulations promulgated  thereunder,  state securities
laws and  regulations,  and the  regulations  of any stock exchange on which the
Company's securities may then be listed.

SECTION 11.  NO RETENTION RIGHTS.

         Neither the Plan nor any Option shall be deemed to give any  individual
a right to remain an  employee,  consultant  or  director  of the  Company  or a
Subsidiary.  The Company and its Subsidiaries reserve the right to terminate the
service of any  employee,  consultant  or director at any time,  with or without
cause,  subject to applicable  laws, the Company's  certificate of incorporation
and by-laws and a written employment agreement (if any).

SECTION 12.  DURATION AND AMENDMENTS.

         (a) Term of the Plan.  The  Plan,  as set forth  herein,  shall  become
         effective  as of  November  16,  1994,  subject to the  approval of the
         Company's  stockholders.  The Plan,  if not extended,  shall  terminate
         automatically  on  September  30,  2004.  It may be  terminated  on any
         earlier date pursuant to Subsection (b) below.

         (b) Right to Amend or Terminate  the Plan.  The Board of Directors  may
         amend,  suspend or  terminate  the Plan at any time and for any reason,
         except  that the  provisions  of Section  4(b)  relating to the amount,
         price and  timing of grants to Outside  Directors  shall not be amended
         more than once in any six-month  period. An amendment of the Plan shall
         be subject to the approval of the  Company's  stockholders  only to the
         extent required by applicable laws or regulations.

         (c) Effect of  Amendment or  Termination.  No Shares shall be issued or
         sold under the Plan after the termination thereof, except upon exercise
         of an Option granted prior to such termination.  The termination of the
         Plan, or any amendment  thereof,  shall not affect any Share previously
         issued or any Option previously granted under the Plan.

SECTION 13.  EXECUTION.

         To record the  amendment  and  restatement  of the Plan by the Board of
Directors on November 4, 1997, the Company has caused its authorized  officer to
execute the same.


                                       NEUROBIOLOGICAL TECHNOLOGIES, INC.

                                       By /s/ Paul E. Freiman
                                          --------------------
                                          President and Chief Executive Officer


                                       12


                                                                    EXHIBIT 23.1


CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the  incorporation by reference in the  Registration  Statement of
Form S-8  pertaining to the Amended and Restated  Neurobiological  Technologies,
Inc. 1993 Stock Plan for the  registration of 500,000 shares of its common stock
of our report  dated July 25, 1997 with  respect to the  consolidated  financial
statements of Neurobiological Technologies Inc. included in the Annual Report of
Form 10 KSB for the year ended June 30, 1997, as filed with the  Securities  and
Exchange Commission.

                                                               ERNST & YOUNG LLP

San Francisco, California
January 7, 1998


                                       13

                                                                    EXHIBIT 24.1

POWER OF ATTORNEY

         KNOW  ALL MEN BY THESE  PRESENTS,  that  each  person  whose  signature
appears below  constitutes  and appoints  Paul E. Freiman his  attorney-in-fact,
with  power  of  substitution  or him in any and  all  capacities,  to sign  any
amendments to this Registration  Statement,  and to file the same, with exhibits
thereto,  and other documents in connection  therewith,  with the Securities and
Exchange   Commission,   hereby   ratifying   and   confirming   all  that  said
attorney-in-fact,  or his substitute or substitutes,  may do or cause to be done
by virtue thereof.

         Pursuant  to the  requirements  of the  Securities  Act of  1933,  this
registration statement has been signed by the following person in the capacities
and on the date indicated:

Signature                        Title                        Date
- ---------                        -----                        ----

/s/ Paul E. Freiman              President, Chief Executive   January 9, 1998
- ---------------------------      Office,
Paul E. Freiman                  (Principal Executive and
                                  Accounting Officer)
                                  and Director

/s/ Abraham E. Cohen             Director                     January 9, 1998
- ---------------------------
Abraham E. Cohen

/s/ Enoch Callaway               Director                     January 9, 1998
- ---------------------------
Enoch Callaway, M.D.

/s/ Theodore L. Eliot, Jr.       Director                     January 9, 1998
- ---------------------------
Theodore L. Eliot, Jr.

/s/ Abraham D. Sofaer            Director                     January 9, 1998
- ---------------------------
Abraham D. Sofaer

/s/ John B. Stuppin              Director                     January 9, 1998
- ---------------------------
John B. Stuppin



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