NEUROBIOLOGICAL TECHNOLOGIES INC /CA/
SC 13D/A, 1999-11-19
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                       ----------------------------------
                                  SCHEDULE 13D
                                 (Rule 13d-101)

           INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO
    SCHEDULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a)

                               (Amendment No. 1)*





                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   00064124W1
- --------------------------------------------------------------------------------
                                 (CUSIP Number)


- --------------------------------------------------------------------------------
                                   Arthur Rock
                            One Maritime Plaza, #1220
                             San Francisco, CA 94111

           (Name, Address and Telephone Number of Person Authorized to
                      Receive Notices and Communications)

                                November 19, 1999
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of ss.ss.240.13d-1(e),  240.13d-1(f) or 240.13d-1(g), check the
following box [ ].

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule;  including all exhibits.  See  ss.240.13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 (the "Act") or otherwise  subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act.


<PAGE>

<TABLE>
<CAPTION>
                                  SCHEDULE 13D
- ------------------------------------------------

CUSIP No.         00064124W1
- ------------------------------------------------
- ---------- ---------------------------------------------------------------------------------------------------------
<S>        <C>                                                                                          <C>
           NAME OF REPORTING PERSON
    1      S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
           Arthur Rock
- ---------- ---------------------------------------------------------------------------------------------------------
           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP                                             (a)  |_|
    2                                                                                                   (b)  |_|

- ---------- ---------------------------------------------------------------------------------------------------------
    3      SEC USE ONLY

- ---------- ---------------------------------------------------------------------------------------------------------
    4      SOURCE OF FUNDS    PF

- ---------- ---------------------------------------------------------------------------------------------------------
    5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS 2(d) or 2(e)           |_|

- ---------- ---------------------------------------------------------------------------------------------------------
    6      CITIZENSHIP OR PLACE OF ORGANIZATION United States of America

- ---------- ---------------------------------------------------------------------------------------------------------
                                7     SOLE VOTING POWER
           NUMBER                     1,664,997 shares of Common Stock(1)
             OF
                             -------- ------------------------------------------------------------------------------
           SHARES               8     SHARED VOTING POWER
        BENEFICIALLY                  None
           OWNED
                             -------- ------------------------------------------------------------------------------
             BY                 9     SOLE DISPOSITIVE POWER
            EACH                      1,664,997 shares of Common Stock(1)
         REPORTING
                             -------- ------------------------------------------------------------------------------
           PERSON               10    SHARED DISPOSITIVE POWER
            WITH                      None
- ---------------------------- -------- ------------------------------------------------------------------------------
    11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           1,664,997 shares of Common Stock(1)

- ---------- ---------------------------------------------------------------------------------------------------------
    12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES                             |X|

- ---------- ---------------------------------------------------------------------------------------------------------
    13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           11.8%
- ---------- ---------------------------------------------------------------------------------------------------------
    14     TYPE OF REPORTING PERSON
           IN
- ---------- ---------------------------------------------------------------------------------------------------------
<FN>

- --------------
(1) Consists of (i) 749,926  shares of Common Stock,  (ii) 400,000  shares of Common Stock issuable upon exercise of
    Common Stock purchase warrants, (iii) 500,000 of Common Stock issuable upon the conversion of Series A Preferred
    Stock and (iv) 15,071 shares of Common Stock  issuable upon exercise of stock  options.  Amount  excludes  2,018
    shares of Common  Stock held by Toni Rembe  Rock (the  Reporting  Person's  spouse),  with  respect to which the
    Reporting Person disclaims beneficial ownership.
</FN>
</TABLE>

                                                          2
<PAGE>


ITEM 1.           SECURITY AND ISSUER

                  This  Statement on Schedule 13D (the  "Statement")  relates to
the Common  Stock  ("Common  Stock") of  Neurobiological  Technologies,  Inc., a
Delaware  corporation  (the "Issuer").  The principal  executive  offices of the
Issuer are located at 1387 Marina Way South, Richmond, California 94804.

ITEM 2.           IDENTITY AND BACKGROUND

                  This  Statement  is  filed  on  behalf  of  Arthur  Rock  (the
"Reporting Person").

                  (a)      Arthur Rock

                  (b)      One Maritime Plaza, #1220
                           San Francisco, CA  94111

                  (c)      Venture Capital

                  (d) During the last five years,  the Reporting  Person has not
been convicted in a criminal proceeding (excluding traffic violations or similar
misdemeanors).

                  (e) During the last five years,  the Reporting  Person has not
been a party to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction as a result of which, he was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

                  (f)      United States of America.

ITEM 3.           SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

                  On November 9, 1999, the Reporting  Person  purchased  250,000
shares (the "Shares") of Common Stock of the Company (the "Common  Stock") and a
stock  purchase  warrant (the  "Warrant") to purchase  100,000  shares of Common
Stock of the Company (the "Warrant  Shares") for an aggregate  purchase price of
$200,000.  The source of funds for the  purchase  of the  Common  Shares and the
Warrant  was  the  Reporting  Person's  personal  funds.  The  Reporting  Person
currently  anticipates  that the source of funds for the  exercise  price of the
Warrant will be his personal funds.

ITEM 4.           PURPOSE OF TRANSACTION

                  The Reporting  Person purchased the Shares and the Warrant for
investment  purposes.  The Reporting Person does not currently have any plans or
proposals which relate to or would result in any matters set forth in Items 4(a)
through 4(j).

                                       3
<PAGE>

ITEM 5.           INTEREST IN SECURITIES OF THE ISSUER

         (a)      As of  the  date  of  this  Statement,  the  Reporting  Person
                  beneficially  owned 1,664,997(2) shares of the Issuer's Common
                  Stock,  representing   approximately  11.8%  of  the  Issuer's
                  outstanding shares of Common Stock.

         (b)      Except  pursuant to applicable  community  property  laws, the
                  Reporting Person has sole power to vote and to direct the vote
                  of, and sole power to dispose or to direct the  disposition of
                  1,664,997(2) shares of the Issuer's Common Stock.

         (c)      On  September  15,  1999,  the  Reporting  Person  exercised a
                  warrant to purchase  100,000  shares of Common  Stock on a net
                  exercise basis, resulting in the issuance of 25,233 shares. On
                  November 9, 1999,  the Reporting  Person  purchased the Shares
                  and the Warrant for an aggregate purchase price of $200,000.

         (d)      Except  pursuant to  applicable  community  property  laws, no
                  other  person  is known to the  Reporting  Person  to have the
                  right  to  receive  or the  power to  direct  the  receipt  of
                  dividends  from,  or proceeds  from the sale of, any shares of
                  Common Stock beneficially owned by the Reporting Person on the
                  date of this Statement.

         (e)      Not applicable.

ITEM 6.           CONTRACTS, ARRANGEMENTS,  UNDERSTANDINGS OR RELATIONSHIPS WITH
                  RESPECT TO SECURITIES OF THE ISSUER

                  Not applicable.

ITEM 7.           MATERIAL TO BE FILED AS EXHIBITS

                  The following documents are filed as exhibits hereto:

                  Exhibit A              Form of Subscription Agreement

                  Exhibit B              Form of Warrant

- --------------
(2) Consists of (i)  749,926  shares of Common  Stock,  (ii)  400,000  shares of
    Common Stock issuable upon exercise of Common Stock purchase warrants, (iii)
    500,000 of Common Stock  issuable upon the  conversion of Series A Preferred
    Stock and (iv) 15,071 shares of Common Stock issuable upon exercise of stock
    options.  Amount  excludes  2,018  shares of Common Stock held by Toni Rembe
    Rock (the Reporting  Person's  spouse),  with respect to which the Reporting
    Person disclaims beneficial ownership.

                                       4
<PAGE>


                                    SIGNATURE

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Dated:  November 19, 1999


By: /s/ Arthur Rock
    -----------------------------
    Name: Arthur Rock


                                       5
<PAGE>


                                  EXHIBIT INDEX



                                                                    Sequentially
  Exhibit             Document Description                         Numbered Page
  ------              --------------------                         -------------

  Exhibit A           Form of Subscription Agreement

  Exhibit B           Form of Warrant




                                       6
<PAGE>

                                    EXHIBIT A

                                                                  Warrant No. __

                        WARRANT TO PURCHASE A MAXIMUM OF
                      _________ SHARES OF COMMON STOCK OF
                       NEUROBIOLOGICAL TECHNOLOGIES, INC.

                          (Void after __________, 2004)


THESE  SECURITIES HAVE NOT BEEN REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS
AMENDED.  THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE
ABSENCE OF A  REGISTRATION  STATEMENT IN EFFECT WITH  RESPECT TO THE  SECURITIES
UNDER SUCH ACT OR AN OPINION OF COUNSEL  SATISFACTORY  TO THE COMPANY  THAT SUCH
REGISTRATION IS NOT REQUIRED OR UNLESS SOLD PURSUANT TO RULE 144 OF SUCH ACT.

THIS WARRANT AND THE SHARES PURCHASABLE HEREUNDER ARE SUBJECT TO RESTRICTIONS ON
TRANSFER AS SET FORTH HEREIN.


                  This certifies that _____________ (the "Holder"),  or assigns,
for value received,  is entitled to purchase from Neurobiological  Technologies,
Inc., a Delaware  corporation  (the  "Company"),  subject to the terms set forth
below, a maximum of __________ fully paid and  nonassessable  shares (subject to
adjustment  as provided  herein) of the  Company's  Common  Stock (the  "Warrant
Shares") for cash at a price of $1.75 per share (the "Exercise  Price") (subject
to  adjustment  as  provided  herein) at any time or from time to time up to and
including  5:00 p.m.  (California  Time) on _________,  2004,  (the  "Expiration
Date") upon  surrender to the Company at its principal  office (or at such other
location  as the  Company  may  advise the Holder in  writing)  of this  Warrant
properly  endorsed with the Form of Subscription  attached hereto duly filled in
and signed and upon payment in cash or by check of the aggregate  Exercise Price
for the number of shares for which this Warrant is being exercised determined in
accordance  with  the  provisions  hereof.  The  Exercise  Price is  subject  to
adjustment  as provided  in Section 3 of this  Warrant.  This  Warrant is issued
subject to the following terms and conditions:

         1.       Exercise,  Issuance of  Certificates,  Reduction  in Number of
                  Warrant Shares.

                  1.1 General.  This Warrant is exercisable at the option of the
Holder of record hereof on or prior to the Expiration  Date, at any time or from
time to time  following its issuance,  for all or any part of the Warrant Shares
(but not for a fraction of a

<PAGE>

share) which may be purchased hereunder, as that number may be adjusted pursuant
to  Section 3 of this  Warrant.  The  Company  agrees  that the  Warrant  Shares
purchased  under this Warrant shall be and are deemed to be issued to the Holder
hereof as the record owner of such Warrant Shares as of the close of business on
the date on which this Warrant shall have been surrendered,  properly  endorsed,
the completed and executed Form of Subscription delivered,  and payment made for
such Warrant Shares. Certificates for the Warrant Shares so purchased,  together
with any other  securities  or property  to which the Holder  hereof is entitled
upon such  exercise,  shall be delivered to the Holder  hereof by the Company at
the  Company's  expense not later than 10 days after the rights  represented  by
this Warrant have been so exercised.  In case of a purchase of less than all the
Warrant  Shares which may be purchased  under this  Warrant,  the Company  shall
cancel  this  Warrant and  execute  and  deliver to the Holder  hereof  within a
reasonable  time a new  Warrant or Warrants of like tenor for the balance of the
Warrant Shares  purchasable  under the Warrant  surrendered  upon such purchase.
Each stock  certificate  so delivered  shall be  registered  in the name of such
Holder.

                  1.2  Net  Issue  Exercise  of  Warrant.   Notwithstanding  any
provisions  herein to the  contrary,  if the fair  market  value of one share of
Common Stock is greater than the Exercise  Price (at the date of  calculation as
set forth below),  in lieu of exercising this Warrant for cash, Holder may elect
to receive  shares of Common Stock equal to the value (as  determined  below) of
this  Warrant (or the portion  thereof  being  canceled)  by  surrender  of this
Warrant  at the  principal  office of the  Company  together  with the  properly
endorsed  Form of  Subscription  in which event the  Company  shall issue to the
Holder a number of shares of Common Stock computed using the following formula:

                           X=       Y (A-B)
                                    -------
                                       A

         Where             X=       the  number of shares of Common  Stock to be
                                    issued to Holder;

                           Y=       the   number  of  shares  of  Common   Stock
                                    purchasable  under the Warrant or, if only a
                                    portion of the  Warrant is being  exercised,
                                    the  portion of the Warrant  being  canceled
                                    (at the date of such calculation);

                           A=       the fair  market  value of one  share of the
                                    Company's  Common Stock (at the date of such
                                    calculation); and

                           B=       Exercise  Price (as  adjusted to the date of
                                    such calculation).

For  purposes of the above  calculation,  the fair market  value of one share of
Common  Stock shall be the  average of the  closing bid and asked  prices of the
Common Stock quoted in the over-the-counter  market summary or the last reported
sale  price of the  Common  Stock or the  closing  price  quoted  on the  Nasdaq
National  Market  System or on any exchange on which the Common Stock is listed,
whichever is  applicable,  as

                                       2
<PAGE>

published in The Wall Street Journal for the five trading days prior to the date
of determination of fair market value.

         2. Shares to be Fully Paid.  The Company  covenants and agrees that all
Warrant  Shares,  will,  upon  issuance  and,  if  applicable,  payment  of  the
applicable  Exercise Price, be duly authorized,  validly issued,  fully paid and
nonassessable,  and free of all liens and encumbrances,  except for restrictions
on transfer provided for herein or under applicable federal and state securities
laws.

         3.  Adjustment  of Exercise  Price and Number of Shares.  The  Exercise
Price and the total number of Warrant Shares shall be subject to adjustment from
time to time upon the occurrence of certain events  described in this Section 3.
Upon each  adjustment  of the Exercise  Price,  the Holder of this Warrant shall
thereafter be entitled to purchase,  at the Exercise  Price  resulting from such
adjustment,  the number of shares  obtained by multiplying the Exercise Price in
effect  immediately prior to such adjustment by the number of shares purchasable
pursuant hereto  immediately prior to such adjustment,  and dividing the product
thereof by the Exercise Price resulting from such adjustment.

                  3.1  Subdivision or Combination of Stock.  In case the Company
shall at any time  subdivide  its  outstanding  shares  of Common  Stock  into a
greater number of shares, the Exercise Price in effect immediately prior to such
subdivision  shall be  proportionately  reduced and the number of Warrant Shares
issuable  hereunder  proportionately  increased,  and  conversely,  in case  the
outstanding  shares of the Common Stock of the Company  shall be combined into a
smaller number of shares, the Exercise Price in effect immediately prior to such
combination shall be proportionately  increased and the number of Warrant Shares
issuable hereunder proportionately decreased.

                  3.2  Reclassification.  If any reclassification of the capital
stock of the Company or any reorganization,  consolidation, merger, or any sale,
lease,  license,  exchange or other transfer (in one  transaction or a series of
related transactions) of all or substantially all, of the business and/or assets
of the Company (the  "Reclassification  Events") shall be effected in such a way
that holders of Common Stock shall be entitled to receive stock, securities,  or
other assets or property,  then, as a condition of such  Reclassification  Event
lawful and adequate  provisions  shall be made  whereby the Holder  hereof shall
thereafter  have the right to  purchase  and  receive  (in lieu of the shares of
Common Stock of the Company immediately  theretofore  purchasable and receivable
upon the  exercise  of the  rights  represented  hereby)  such  shares of stock,
securities, or other assets or property as may be issued or payable with respect
to or in exchange for a number of outstanding  shares of such Common Stock equal
to the number of shares of such stock  immediately  theretofore  purchasable and
receivable  upon  the  exercise  of  the  rights  represented   hereby.  In  any
Reclassification Event,  appropriate provision shall be made with respect to the
rights  and  interests  of the  Holder  of  this  Warrant  to the end  that  the
provisions hereof (including, without limitation,  provisions for adjustments of
the

                                       3
<PAGE>

Exercise  Price and of the  number  of  Warrant  Shares),  shall  thereafter  be
applicable, as nearly as may be, in relation to any shares of stock, securities,
or assets thereafter deliverable upon the exercise hereof.

                  3.3 Stock Dividends,  etc. Except as hereinafter  provided, in
case the  Company  shall at any time after the date  hereof  issue any shares of
Common  Stock  (including  shares  held  in  the  Company's   treasury)  without
consideration,  then,  and  thereafter  successively  upon  each  issuance,  the
Exercise Price in effect immediately prior to each such issuance shall forthwith
be reduced to a price  determined by  multiplying  the Exercise  Price in effect
immediately prior to such issuance by a fraction:


                  (a) the numerator of which shall be the total number of shares
                  of  Common  Stock   outstanding   immediately  prior  to  such
                  issuance, and

                  (b) the  denominator  of which  shall be the  total  number of
                  shares of Common  Stock  outstanding  immediately  after  such
                  issuance.

         For  purposes  of any  computation  to be made in  accordance  with the
provisions  of this  Section  3.3,  shares of Common  Stock  issuable  by way of
dividend or other  distribution  on any stock of the Company  shall be deemed to
have been  issued  and to be  outstanding  at the close of the  business  on the
record date fixed for the determination of stockholders entitled to receive such
dividend or other  distribution  and shall be deemed to have been issued without
consideration. Shares of Common Stock issued otherwise than as a dividend, shall
be deemed to have been issued and to be  outstanding at the close of business on
the date of issue.

                  3.4 Notice of Adjustment.  Upon any adjustment of the Exercise
Price or any increase or decrease in the number of Warrant  Shares,  the Company
shall  give  written  notice  thereof,  by first  class  mail  postage  prepaid,
addressed to the registered Holder of this Warrant at the address of such Holder
as shown on the books of the Company. The notice shall be prepared and signed by
the  Company's  Chief  Financial  Officer  and shall  state the  Exercise  Price
resulting  from such  adjustment  and the increase or  decrease,  if any, in the
number of shares  purchasable  at such price upon the exercise of this  Warrant,
setting forth in reasonable  detail the method of calculation and the facts upon
which such calculation is based.

         4. No Voting or Dividend  Rights.  Nothing  contained  in this  Warrant
shall be construed as conferring  upon the holder hereof the right to vote or to
consent to receive  notice as a shareholder  of the Company on any other matters
or any rights  whatsoever  as a  shareholder  of the  Company.  No  dividends or
interest  shall be payable or accrued in respect of this Warrant or the interest
represented  hereby or the shares  purchasable  hereunder until, and only to the
extent that, this Warrant shall have been exercised.

                                       4
<PAGE>

         5.  Compliance  with  Securities  Act;   Transferability   of  Warrant;
Disposition of Shares of Stock.

                  5.1  Compliance  with  Securities  Act.  The  Holder  of  this
Warrant,  by acceptance hereof,  agrees that this Warrant and the Warrant Shares
to be issued upon exercise  hereof are being acquired for investment and that it
will not offer, sell, or otherwise dispose of this Warrant or any Warrant Shares
except  under  circumstances  which  will  not  result  in a  violation  of  the
Securities  Act  of  1933,  as  amended  (the  "Act")  or any  applicable  state
securities  laws.  The Holder  agrees that the Company is under no obligation to
register the Warrants and the Warrant Shares,  and Holder  acknowledges that the
Company  does not  intend to cause such a  registration.  This  Warrant  and all
Warrant Shares shall be stamped or imprinted with a legend in substantially  the
following form:

                  THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED OR THE  SECURITIES  OR BLUE SKY LAWS OF ANY STATE.  THEY
MAY NOT BE SOLD, OFFERED FOR SALE,  PLEDGED, OR HYPOTHECATED IN THE ABSENCE OF A
REGISTRATION  STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES  UNDER SUCH ACT
OR AN OPINION OF COUNSEL  SATISFACTORY TO THE COMPANY THAT SUCH  REGISTRATION IS
NOT REQUIRED, OR UNLESS SOLD PURSUANT TO RULE 144 OF SUCH ACT.

                  5.2 Access to Information;  Pre Existing Relationship.  Holder
has had the  opportunity  to ask  questions  of,  and to receive  answers  from,
appropriate  executive  officers  of the Company  with  respect to the terms and
conditions  of the  transactions  contemplated  hereby  and with  respect to the
business, affairs, financial condition and results of operations of the Company.
Holder has had access to such financial and other information as is necessary in
order for  Holder to make a fully  informed  decision  as to  investment  in the
Company,  and has had the  opportunity  to  obtain  any  additional  information
necessary  to verify any of such  information  to which  Holder has had  access.
Holder  further  represents  and warrants that he has either (i) a  pre-existing
relationship  with  the  Company  or one or more of its  officers  or  directors
consisting  of  personal or business  contacts  of a nature and  duration  which
enable him to be aware of the character,  business  acumen and general  business
and financial  circumstances of the Company or the officer or director with whom
such relationship  exists or (ii) such business or financial  expertise as to be
able to protect his own interests in connection with the purchase of the Shares.

                  5.3  Warrant   Transferable.   Subject  to   compliance   with
applicable  federal  and state  securities  laws under  which this  Warrant  was
purchased,  this Warrant and all rights hereunder are transferable,  in whole or
in part,  without  charge  to the  Holder  (except  for  transfer  taxes),  upon
surrender of this Warrant properly endorsed;  provided, however, that the Holder
shall notify the Company in writing in advance of any proposed transfer,  and if
the Company notifies the Holder within 5 business days of receipt of such

                                       5
<PAGE>

notice  that such  person or entity is then  engaged in a  business  that in the
reasonable  judgment of the Company is in direct  competition  with the Company,
Holder shall not transfer this Warrant or any rights hereunder to such person or
entity.

                  5.4  Disposition  of Warrant  Shares and  Common  Stock.  With
respect to any offer,  sale, or other  disposition of the Warrant or any Warrant
Shares,  the Holder hereof and each subsequent  Holder of this Warrant agrees to
give written notice to the Company prior thereto,  describing briefly the manner
thereof, together with a written opinion of such Holder's counsel, if reasonably
requested  by the  Company,  to the  effect  that  such  offer,  sale  or  other
disposition may be effected without registration or qualification (under the Act
as then in effect or any federal or state law then in effect) of such Warrant or
Warrant Shares, as the case may be, and indicating  whether or not under the Act
certificates for such Warrant or Warrant Shares to be sold or otherwise disposed
of  require  any   restrictive   legend  as  to   applicable   restrictions   on
transferability  in order to insure compliance with the Act. Upon receiving such
written  notice and opinion,  the  Company,  as promptly as  practicable,  shall
notify  such  Holder  that such  Holder  may sell or  otherwise  dispose of such
Warrant  or  Warrant  Shares,  all in  accordance  with the terms of the  notice
delivered  to the Company.  If a  determination  has been made  pursuant to this
Section 5.4 that the  opinion of the  counsel  for the Holder is not  reasonably
satisfactory  to the Company,  the Company  shall so notify the Holder  promptly
after such  determination  has been made.  Notwithstanding  the foregoing,  such
Warrant or Warrant  Shares may be  offered,  sold or  otherwise  disposed  of in
accordance  with Rule 144 under the Act,  provided  that the Company  shall have
been  furnished  with such  information  as the  Company  may request to provide
reasonable  assurance that the provisions of Rule 144 have been satisfied.  Each
certificate  representing the Warrant or Warrant Shares thus transferred (except
a  transfer  pursuant  to Rule 144)  shall  bear a legend  as to the  applicable
restrictions  on  transferability  in order to ensure  compliance  with the Act,
unless in the  aforesaid  opinion of counsel for the Holder,  such legend is not
required in order to ensure  compliance with the Act. The Company may issue stop
transfer   instructions   to  its  transfer   agent  in  connection   with  such
restrictions.

         6.  Modification and Waiver.  This Warrant and any provision hereof may
be changed, waived,  discharged,  or terminated only by an instrument in writing
signed by the party against which enforcement of the same is sought.

         7.  Notices.  Any  notice,  request,  or  other  document  required  or
permitted to be given or delivered to the Holder  hereof or the Company shall be
delivered  or shall be sent by certified  mail,  postage  prepaid,  to each such
Holder at its  address as shown on the books of the Company or to the Company at
the address  indicated  therefor in the first  paragraph of this Warrant or such
other address as either may from time to time provide to the other.

                                       6
<PAGE>

         8.       Other Notices.  If at any time:

                  (1) the  Company  shall  declare  any cash  dividend  upon its
Common Stock;

                  (2) the Company  shall  declare any  dividend  upon its Common
Stock payable in stock or make any special dividend or other distribution to the
holders of its Common Stock;

                  (3) the Company shall offer for  subscription  pro rata to the
holders of its Common Stock any additional shares of stock of any class or other
rights;

                  (4)   there   shall   be   any   capital   reorganization   or
reclassification of the capital stock of the Company, or consolidation or merger
of the  Company  with,  or sale of all or  substantially  all of its  assets to,
another corporation; or

                  (5) there shall be a  voluntary  or  involuntary  dissolution,
liquidation, or winding-up of the Company;

then,  in any one or more of said cases,  the Company shall give, by first class
mail, postage prepaid, addressed to the Holder of this Warrant at the address of
such  Holder as shown on the books of the  Company,  (a) at least 20 days' prior
written  notice of the date on which the books of the  Company  shall close or a
record shall be taken for such dividend, distribution, or subscription rights or
for  determining  rights  to  vote  in  respect  of  any  such   reorganization,
reclassification,  consolidation,  merger, sale,  dissolution,  liquidation,  or
winding-up,  and (b) in the case of any such  reorganization,  reclassification,
consolidation, merger, sale, dissolution, liquidation or winding-up, at least 20
days' prior written notice of the date when the same shall take place; provided,
however,  that the Holder shall make a best  efforts  attempt to respond to such
notice as early as  possible  after the  receipt  thereof.  Any notice  given in
accordance with the foregoing clause (a) shall also specify,  in the case of any
such  dividend,  distribution,  or  subscription  rights,  the date on which the
holders  of  Common  Stock  shall  be  entitled  thereto.  Any  notice  given in
accordance  with the  foregoing  clause (b) shall also specify the date on which
the holders of Common Stock shall be entitled to exchange their Common Stock for
securities   or   other   property   deliverable   upon   such   reorganization,
reclassification,   consolidation,   merger,  sale,  dissolution,   liquidation,
winding-up or conversion, as the case may be.

         9.  Governing  Law.  This Warrant  shall be  construed  and enforced in
accordance with, and the rights of the parties shall be governed by, the laws of
the State of California.

         10. Lost  Warrants.  The Company  represents and warrants to the Holder
hereof that upon receipt of evidence  reasonably  satisfactory to the Company of
the loss, theft, destruction,  or mutilation of this Warrant and, in the case of
any such loss,  theft or

                                       7
<PAGE>


destruction,  upon  receipt  of an  indemnity  reasonably  satisfactory  to  the
Company,  or in the case of any such mutilation upon surrender and  cancellation
of such  Warrant,  the  Company,  at its  expense,  will make and  deliver a new
Warrant,  of like tenor,  in lieu of the lost,  stolen,  destroyed  or mutilated
Warrant.

         11.  Fractional  Shares.  No  fractional  shares  shall be issued  upon
exercise of this Warrant.  The Company shall,  in lieu of issuing any fractional
share,  pay the  Holder  entitled  to such  fraction a sum in cash equal to such
fraction  (calculated to the nearest 1/100th of a share)  multiplied by the then
effective Exercise Price on the date the Form of Subscription is received by the
Company.

         12. No  Impairment.  The Company  will not, by charter  amendment or by
reorganization, transfer of assets, consolidation, merger, dissolution, issue or
sale of securities,  or any other voluntary  action,  avoid or seek to avoid the
observance or performance of any terms of this Warrant, but will at all times in
good faith assist in the carrying out of all such terms and in the taking of all
such action as may be necessary or appropriate in order to protect the rights of
the Holder against impairment.  Upon the request of the Holder, the Company will
at any time  during  the  period  this  Warrant is  outstanding  acknowledge  in
writing,  in form satisfactory to Holder, the continued validity of this Warrant
and the Company's obligations hereunder.

         13.  Successors  and  Assigns.  This  Warrant and the rights  evidenced
hereby shall inure to the benefit of and be binding upon the  successors  of the
Company and the Holder.  The  provisions  of this Warrant are intended to be for
the  benefit  of all  Holders  from time to time of this  Warrant,  and shall be
enforceable by any such Holder.

                  IN WITNESS WHEREOF,  the Company has caused this Warrant to be
duly executed by its officer,  thereunto duly  authorized as of this ____ day of
_________, 1999.

                                        NEUROBIOLOGICAL TECHNOLOGIES, INC.
                                        a Delaware corporation


                                        By:    _________________________________

                                        Name:  _________________________________

                                        Title: _________________________________


                                       8

<PAGE>


                              FORM OF SUBSCRIPTION

(To be signed only upon exercise of Warrant)

To:  Neurobiological Technologies, Inc.

[Please mark one box]

[ ]      The  undersigned,  the holder of the attached  Common Stock  Warrant,
         hereby irrevocably elects to exercise the purchase right represented by
         such Warrant for, and to purchase thereunder, (1)_______________ shares
         of Common Stock of Neurobiological  Technologies,  Inc. (the "Company")
         and herewith makes payment of $_______________  therefor,  and requests
         certificates  for such  shares be issued in the name of, and  delivered
         to,_______________                     whose                    address
         is_____________________________________________.

[ ]      The  undersigned,  the holder of the attached  Common Stock  Warrant,
         hereby irrevocably elects to exercise the purchase right represented by
         such Warrant for, and to purchase thereunder, (1)_______________ shares
         of Common  Stock of the  Company  and  herewith  elects to pay for such
         shares  by  reducing  the  number  of  shares  issuable  thereunder  in
         accordance with Section 1.2 thereof.  The undersigned hereby authorizes
         the Company to make the required  calculation  under Section 1.2 of the
         Warrant.

         The  undersigned  represents that it is acquiring such Common Stock for
its own account for  investment and not with a view to or for sale in connection
with any distribution thereof.

DATED:   _________________, _____


                                           _____________________________________
                                           (Signature   must   conform   in  all
                                           respects   to  name  of   Holder   as
                                           specified on the face of the Warrant)


                                           Name:________________________________


                                           Title:_______________________________


(1) Insert here the number of shares  called for on the face of the Warrant (or,
    in the case of a  partial  exercise,  the  portion  thereof  as to which the
    Warrant is being  exercised),  in either case without making any adjustments
    for any stock or other securities or property

                                       9
<PAGE>

    or cash which,  pursuant to the adjustment provisions of the Warrant, may be
    deliverable upon exercise.



                                       10
<PAGE>


THE SECURITIES  OFFERED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED,  OR QUALIFIED UNDER  APPLICABLE  STATE  SECURITIES LAWS AND
HAVE BEEN TAKEN FOR INVESTMENT  PURPOSES ONLY AND NOT WITH A VIEW TO OR FOR SALE
IN CONNECTION WITH ANY DISTRIBUTION  THEREOF.  THEY MAY NOT BE SOLD OR OTHERWISE
TRANSFERRED  IN THE  ABSENCE OF SUCH  REGISTRATION  AND  QUALIFICATION  WITHOUT,
EXCEPT  UNDER  CERTAIN  SPECIFIC  LIMITED  CIRCUMSTANCES,  AN OPINION OF COUNSEL
REASONABLY  SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION AND QUALIFICATION
ARE NOT REQUIRED.

THE SALE OF THE  SECURITIES  THAT ARE THE SUBJECT OF THIS AGREEMENT HAS NOT BEEN
QUALIFIED WITH THE  COMMISSIONER  OF CORPORATIONS OF THE STATE OF CALIFORNIA AND
THE  ISSUANCE  OF THE  SECURITIES  OR THE  PAYMENT OR RECEIPT OF ANY PART OF THE
CONSIDERATION  THEREFOR PRIOR TO THE QUALIFICATION IS UNLAWFUL,  UNLESS THE SALE
OF SECURITIES IS EXEMPT FROM  QUALIFICATION BY SECTION 25100,  25102 OR 25105 OF
THE  CALIFORNIA  CORPORATIONS  CODE. THE RIGHTS OF ALL PARTIES TO THIS AGREEMENT
ARE EXPRESSLY CONDITIONED UPON THE QUALIFICATION BEING OBTAINED, UNLESS THE SALE
IS SO EXEMPT.

                             SUBSCRIPTION AGREEMENT


Neurobiological Technologies, Inc.
1387 Marina Way South
Richmond, California 94804
Attn:  Chief Executive Officer

Gentlemen:

         1. Subscription.

                  (a) The undersigned is hereby purchasing from  Neurobiological
Technologies,  Inc., a Delaware  corporation (the  "Company"),  _____ units (the
`Units"),  each  consisting  of (i) five shares (the  "Shares") of the Company's
Common  Stock,  $0.001 par value (the "Common  Stock");  and (ii) a Common Stock
Purchase  Warrant,  in the form of Exhibit A (the  "Warrant"),  to purchase  two
shares of Common  Stock.  The Shares and the  Warrants are referred to herein as
the  "Securities."  The  undersigned  understands and agrees that the Company is
only  offering  the Shares and the  Warrants  together  as a Unit,  and that the
Shares and Warrants may only be purchased as a Unit.  The purchase price of each
Unit shall be $4.00 for an aggregate  purchase price of $________ (the "Purchase
Price").


<PAGE>

                  (b) This  subscription  is  submitted  to the  undersigned  in
accordance  with and  subject  to the terms  and  conditions  described  in this
Subscription  Agreement  relating to the offering of up to 937,500 Units; with a
minimum  subscription of 687,500 Units required to consummate the offering.  The
Company reserves the right to amend,  modify and/or withdraw all or a portion of
the  offering  and to  increase  or  decrease  the number of Units to be offered
hereby.

         2.      (a) Purchase Price. The undersigned has tendered, together with
this Subscription  Agreement,  the Purchase Price by electronic wire transfer in
accordance with the following instructions:

                  Bank Name                     Wells Fargo Bank
                  Bank Address:                 420 Montgomery Street, 5th Floor
                                                San Francisco, CA 94104
                  ABA#:                         121000248
                  WFB Account #:                4159 427 152

                  For further credit to Acct
                  Neurobiological Technologies, Inc.
                  Attn:  Alice Byrd

or  by  delivery  of  a  bank  check  or   certified   check  made   payable  to
Neurobiological  Technologies,  Inc.  against  delivery to the  undersigned of a
certificate representing the Securities.


                  (b)  Closing.  The  closing  of the sale and  purchase  of the
Securities  shall  occur on the date  hereof or on such  other  date as shall be
selected by the Company (the "Closing  Date").  The  Securities  subscribed  for
under this  Subscription  Agreement  shall not be deemed issued to, or owned by,
the undersigned until the Closing Date has occurred.

                  (c) Acceptance or Rejection.  The undersigned  understands and
agrees that the Company  reserves  the right,  in its  absolute  discretion,  to
reject this  subscription  for the  Securities  in whole or in part, at any time
prior to the Closing Date. In the event of rejection of this subscription, or in
the event the sale of the Securities is not consummated for any reason within 20
days  after  the  date of this  Subscription  Agreement  (in  which  event  this
Subscription Agreement shall be deemed to be rejected),  the Company shall cause
the return to the  undersigned of this  Subscription  Agreement and the Purchase
Price tendered by the undersigned,  and this Subscription  Agreement  thereafter
shall be of no force or effect.

                                       2
<PAGE>

         3.  Representations  and  Warranties  of the  Company.  To  induce  the
undersigned  to enter  into this  Subscription  Agreement  and to  purchase  the
Securities,  the Company hereby  represents and warrants to the  undersigned the
following:

                  (a) Organization,  Standing, Etc. The Company is a corporation
duly  organized,  validly  existing and in good  standing  under the laws of the
State of Delaware and has the requisite  corporate power and authority to own or
lease its properties and to carry on its business as it is now being  conducted.
The  Company  has the  requisite  corporate  power  and  authority  to issue the
Securities and to perform its obligations under this Subscription Agreement.

                  (b) Valid Issuance. The Securities,  when issued and delivered
pursuant to the terms of this Subscription  Agreement,  will be duly authorized,
validly  issued,  fully  paid and  nonassessable.  The  shares of  Common  Stock
issuable  upon  exercise of the Warrants  (the  "Underlying  Securities"),  when
issued  and  delivered  pursuant  to the  terms  of the  Warrants,  will be duly
authorized, validly issued, fully paid and nonassessable.

                  (c)  Corporate  Acts  and   Proceedings.   This   Subscription
Agreement has been duly authorized by all necessary  corporate  action on behalf
of the Company, has been duly executed and delivered by an authorized officer of
the Company,  is a valid and binding agreement on the part of the Company and is
enforceable  against the Company in  accordance  with its terms.  All  corporate
actions necessary to the authorization,  creation,  issuance and delivery of the
Shares, Warrants and the Underlying Securities have been taken by the Company.

                  (d) Compliance  with  Applicable  Laws and Other  Instruments.
Neither the execution nor delivery of, nor the performance of or compliance with
this Subscription  Agreement,  the issuance of the Shares,  the Warrants and the
Underlying  Securities nor the  consummation  of the  transactions  contemplated
hereby will, with or without the giving of notice or passage of time,  result in
any breach of, or constitute a default under, or result in the imposition of any
lien or encumbrance  upon any asset or property of the Company  pursuant to, any
material agreement or other material  instrument to which the Company is a party
or by which it or any of its properties,  assets or rights is bound or affected,
and will not violate the Company's Certificate of Incorporation or Bylaws.

                  (e) Securities Laws. Based in part upon the representations of
the undersigned in Section 5, no consents,  authorization,  approval,  permit or
order of or filing with any  governmental  or  regulatory  authority is required
under current laws and regulations in connection with the execution and delivery
of this Subscription Agreement or the offer,  issuance,  sale or delivery of the
Shares, the Warrants and the Underlying  Securities,  other than the filing of a
Form D pursuant to  Regulation D under the  Securities  Act of 1933 (the "Act"),
the  filing of a notice on Form  25102(f)  with the  State of  California  and a
similar notice with any other state whose laws require such filing, and

                                       3
<PAGE>

the qualification thereof, if required,  under other applicable state laws which
qualification  has been or will be effected as a condition of this  transaction.
Under the circumstances  contemplated by this Subscription Agreement, the offer,
issuance,  sale and  delivery of the Shares,  the  Warrants  and the  Underlying
Securities will not, under current laws and regulations, require compliance with
the prospectus delivery or registration requirements of the Act.

                  (f) Capital Stock.  Except as set forth on Schedule A attached
hereto,  the authorized and issued capital stock of the Company is correctly set
forth in the  audited  financial  statements  of the Company for the fiscal year
ended June 30, 1999.  All of the  outstanding  shares of the  Company's  capital
stock  are  duly   authorized   and  validly  issued  and  are  fully  paid  and
nonassessable. Except as described in the Company's Annual Report on Form 10-KSB
for the  fiscal  year  ended  June 30,  1999 as filed  with the  Securities  and
Exchange Commission (the "Commission"), or as set forth on Schedule A, there are
no outstanding  subscriptions,  options,  warrants,  calls, contracts,  demands,
commitments,  convertible  securities or other agreements or arrangements of any
character or nature whatever,  other than this Subscription Agreement,  pursuant
to  which  the  Company  is  obligated  to  issue  any  securities  of any  kind
representing an ownership interest in the Company.

                  (g) Company SEC Filings.  The Company has  furnished,  or made
available  through  the  EDGAR  Internet  web  site  of the  Commission,  to the
undersigned true and complete copies of its Annual Report on Form 10-KSB for the
fiscal year ended June 30, 1999 as filed with the Commission (the "SEC Filing").
As of its filing date, the SEC Filing complied in all material respects with the
applicable  requirements  of the Exchange Act of 1934, as amended (the "Exchange
Act"),  and the SEC Filing  contained no untrue  statement of a material fact or
omitted to state a material fact  required to be stated  therein or necessary in
order to make the  statements  made therein,  in the light of the  circumstances
under which they were made, not misleading.

                  (h)  Repayment of Merz Loans.  The Company has given notice to
Merz + Co. GmbH & Co. ("Merz") that it will repay outstanding loans from Merz in
the  aggregate  principal  amount of $1,200,000  plus accrued  interest from the
proceeds of this offering.

         4. Transfer Restrictions.

                  (a) The undersigned realizes that the Shares, the Warrants and
the Underlying  Securities  are not registered  under the Act, or any foreign or
state securities laws. The undersigned  agrees that the Shares, the Warrants and
the  Underlying  Securities  will  not  be  sold,  offered  for  sale,  pledged,
hypothecated,  or otherwise transferred  (collectively,  a "Transfer") except in
compliance  with the Act,  if  applicable,  and  applicable  foreign  and  state
securities  laws. The  undersigned  understands  that the  undersigned  can only
Transfer the Shares, the Warrants and the Underlying Securities

                                       4
<PAGE>

pursuant to  registration  under the Act or pursuant to an exemption  therefrom.
The undersigned  understands  that to Transfer the Shares,  the Warrants and the
Underlying Securities may require in some jurisdictions specific approval by the
appropriate governmental agency or commission in such jurisdiction.

                  (b) To enable the Company to enforce the transfer restrictions
contained in Section 4(a),  the  undersigned  hereby  consents to the placing of
legends upon,  and  stop-transfer  orders with the transfer  agent of the Common
Stock with respect to, the Shares, the Warrants and the Underlying Securities.

         5. Representations and Warranties.  To induce the Company to accept the
undersigned's  subscription,  the undersigned  hereby represents and warrants to
the Company that:

                  (a) the undersigned,  if an individual, has reached the age of
majority in the jurisdiction in which he/she resides, is a bona fide resident of
the  jurisdiction  contained in the address set forth on the  signature  page of
this Subscription  Agreement;  is legally competent to execute this Subscription
Agreement; and does not intend to change residence to another jurisdiction;

                  (b) the  undersigned,  if an  entity,  is duly  authorized  to
execute  this  Subscription  Agreement  and this  Subscription  Agreement,  when
executed and delivered by the undersigned,  will constitute a legal,  valid, and
binding  obligation  enforceable  against the undersigned in accordance with its
terms;  and the  execution,  delivery,  and  performance  of  this  Subscription
Agreement and the consummation of the transactions contemplated hereby have been
duly authorized by all requisite corporate or other necessary action on the part
of the undersigned;

                  (c) the Shares,  Warrants and Underlying Securities subscribed
for hereby are being acquired by the undersigned  for investment  purposes only,
for the  account  of the  undersigned  and not with the  view to any  resale  or
distribution  thereof,  and the  undersigned is not  participating,  directly or
indirectly, in a distribution of such Shares, Warrants and Underlying Securities
and will not  take,  or cause to be  taken,  any  action  that  would  cause the
undersigned  to  be  deemed  an  "underwriter"  of  such  Shares,  Warrants  and
Underlying Securities as defined in Section 2(11) of the Act;

                  (d) the  undersigned  has had access to all materials,  books,
records,  documents, and information relating to the Company,  including (i) the
SEC Filings and (ii) the Proxy  Statement  relating to the Company's 1998 annual
meeting;

                  (e)  the  undersigned   acknowledges   and  understands   that
investment in the Securities  involves a high degree of risk,  including without
limitation  the risks  set forth in the SEC  Filing  under the  captions  "Risks
Associated with Product Development,"

                                       5
<PAGE>

"Management's  Discussion  and  Analysis of Financial  Condition  and Results of
Operations," and elsewhere in the Company's Form 10-KSB;

                  (f) the undersigned acknowledges that the undersigned has been
offered an opportunity to ask questions of, and receive  answers from,  officers
of the Company  concerning all material aspects of the Company and its business,
and that any request for such  information  has been fully  complied with to the
extent  the  Company  possesses  such  information  or can  acquire  it  without
unreasonable effort or expense;

                  (g) the  undersigned  has such  knowledge  and  experience  in
financial and business matters that the undersigned is capable of evaluating the
merits and risks of an  investment in the Company and can afford a complete loss
of his investment in the Company;

                  (h) the  undersigned  has never been  notified by the Internal
Revenue Service that the undersigned is subject to backup withholding;

                  (i) the undersigned recognizes that no governmental agency has
passed upon the issuance of the Shares or made any finding or  determination  as
to the fairness of this investment;

                  (j) if the undersigned is purchasing the Securities subscribed
for hereby in a representative or fiduciary  capacity,  the  representations and
warranties  contained  herein shall be deemed to have been made on behalf of the
person or persons for whom such Securities are being purchased;

                  (k) the  undersigned has not entered into any agreement to pay
commissions  to  any  persons  with  respect  to the  purchase  or  sale  of the
Securities,  except  commissions for which the undersigned  will be responsible;
and

                  (l) the  undersigned is an "Accredited  Investor" as that term
is  defined  in  Section  501(a)  of  Regulation  D  promulgated  under the Act.
Specifically the undersigned is (check appropriate item(s)):

[ ]        (i) a bank as defined in Section 3(a)(2) of the Act, or a savings and
           loan   association  or  other   institution  as  defined  in  Section
           3(a)(5)(A) of the Act whether  acting in its  individual or fiduciary
           capacity; a broker or dealer registered pursuant to Section 15 of the
           Exchange Act; an insurance company as defined in Section 2(13) of the
           Act; an investment  company  registered under the Investment  Company
           Act of 1940 or a business  development  company as defined in Section
           2(a)(48) of that Act; a Small Business Investment Company licensed by
           the U.S. Small Business Administration under Section 301(c) or (d) of
           the Small  Business  Investment Act of 1958; a plan  established  and
           maintained by a state, its political  subdivisions,  or any agency or
           instrumentality  of a state or its  political  subdivisions,  for the
           benefit of its employees,  if such plan has total

                                       6
<PAGE>

           assets in excess of $5,000,000,  an employee  benefit plan within the
           meaning of the Employment  Retirement Income Security Act of 1974, if
           the investment  decision is made by a plan  fiduciary,  as defined in
           Section 3(21) of such act,  which is either a bank,  savings and loan
           association,  insurance company, or registered investment advisor, or
           if  the  employee   benefit  plan  has  total  assets  in  excess  of
           $5,000,000,  or if a self-directed  plan,  with investment  decisions
           made solely by persons that are Accredited Investors;

[ ]        (ii) a private  business  development  company  as defined in Section
           202(a)(22) of the Investment Advisers Act of 1940;

[ ]        (iii) an organization  described in Section 501(c)(3) of the Internal
           Revenue  Code of 1986,  as  amended,  corporation,  Massachusetts  or
           similar  business trust, or partnership,  not formed for the specific
           purpose  of  acquiring  Shares,   with  total  assets  in  excess  of
           $5,000,000;

[ ]        (iv)   a director or executive officer of the Company;

           (v) a natural person whose  individual net worth,  or joint net worth
[ ]        with that person's spouse, at the time of his or her purchase exceeds
           $1,000,000;

[ ]        (vi) a natural person who had an individual income (not including his
           or her  spouse's  income) in excess of  $200,000  in 1997 and 1998 or
           joint  income with his or her spouse in excess of $300,000 in each of
           those years and has a reasonable  expectation of reaching such income
           level in 1999;

[ ]        (vii) a trust, with total assets in excess of $5,000,000,  not formed
           for the  specific  purpose of  acquiring  Shares,  whose  purchase is
           directed  by  a  person  having  such  knowledge  and  experience  in
           financial  and  business  matters  that  he  or  she  is  capable  of
           evaluating  the merits and risks  entailed in the purchase of Shares;
           or

[ ]        (viii) an entity in which all of the  equity  owners  are  Accredited
           Investors.  (If this  alternative is checked,  the  undersigned  must
           identify  each  equity  owner and provide  statements  signed by each
           demonstrating how each is qualified as an Accredited Investor.)

         6.  Registration  of Shares.  On or before a date that is 30 days after
the  Closing  Date,  the Company  shall file with the  Securities  and  Exchange
Commission a registration  statement on Form S-3 to register for resale pursuant
to Section 5 of the Act the Shares and the Underlying Securities sold and issued
to the undersigned in accordance with this Subscription  Agreement.  The Company
will use its best  efforts to cause such  registration  statement to be declared
effective and to remain  available for the resale of such shares and  securities
for a period of 12 months from the effective date, provided,  however,  that the
Company  may  suspend  the  use  of  the  prospectus  constituting  part  of the
registration  statement  for up to two  periods of 60 days each in the event the
Company determines, in

                                       7
<PAGE>

its sole judgment,  that such  prospectus is incomplete,  inaccurate or omits to
disclose any information  required to be included therein, and provided further,
that the period during which the  registration  statement will remain  available
shall be  extended  by any  period in which  the  Company  invoked  its right to
suspend  the use of the  prospectus.  In the event of any such  suspension,  the
Company will promptly  notify the  undersigned  subscriber of the suspension and
use its best efforts to amend or supplement the registration statement,  and the
prospectus  constituting a part thereof, within said 60-day period to enable the
use of the amended or  supplemented  prospectus for the resale of the shares and
securities  covered thereby.  The Company will provide the undersigned with such
copies of the  prospectus,  or any amended or  supplemented  prospectus,  as the
undersigned may reasonably request. The undersigned agrees to cooperate with the
Company in preparing and filing the aforesaid  registration  statement,  and any
amendment  or  supplement  thereto,   and  to  provide  the  Company  with  such
information   and   documentation   as  the  Company  may  reasonably   request.
Notwithstanding anything to the contrary contained herein, the Company shall not
be obligated to maintain the effectiveness of any registration  statement, or to
update,  amend or  supplement  such  registration  statement  or any  prospectus
constituting a part thereof, after the undersigned shall become eligible to sell
all of his shares,  or  remaining  shares,  under Rule 144 of the Act within any
three-month period without volume limitations.

         7. Further Documents.  The undersigned agrees that it will execute such
other  documents  as may be  necessary  or  desirable  in  connection  with  the
transactions contemplated hereby.

         8. Modification. Neither this Subscription Agreement nor any provisions
hereof  shall be  waived,  modified,  discharged,  or  terminated  except  by an
instrument  in  writing  signed  by the  party  against  whom any  such  waiver,
modification, discharge, or termination is sought.

         9. Notices. Any notice or other communication  required or permitted to
be given  hereunder  shall be in writing and shall be mailed by certified  mail,
return  receipt  requested,  or by  Federal  Express,  Express  Mail or  similar
overnight  delivery or courier  service and delivered (in person or by telecopy,
telex or similar  telecommunications  equipment) against receipt to the party to
whom it is to be given,  (i) if to the Company,  at its address set forth on the
first page hereof,  (ii) if to the undersigned,  at its address set forth on the
signature  page hereto,  or (iii) in either case,  to such other  address as the
party shall have furnished in writing in accordance  with the provisions of this
Section 9. Notice to the estate of any party shall be sufficient if addressed to
the party as provided in this Section.  Any notice or other  communication given
by certified  mail shall be deemed given at the time of  certification  thereof,
except for a notice  changing a party's  address  which shall be deemed given at
the time of receipt  thereof.  Any notice given by other means permitted by this
Section 9 shall be deemed given at the time of receipt thereof.


                                       8
<PAGE>


         10. Counterparts.  This Subscription  Agreement may be executed through
the use of separate  signature pages or in any number of counterparts,  and each
such counterpart  shall, for all purposes,  constitute one agreement  binding on
all parties,  notwithstanding  that all parties are not  signatories to the same
counterpart.

         11. Entire Agreement. This Subscription Agreement contains the entire
agreement of the parties with respect to the subject matter hereof and there are
not representations,  covenants or other agreements except as stated or referred
to herein.

         12.  Severability.  Each  provision of this  Subscription  Agreement is
intended to be  severable  from every other  provision,  and the  invalidity  or
illegality  of any portion  hereof  shall not affect the validity or legality of
the remainder hereof.

         13. Assignability.  This Subscription  Agreement is not transferable or
assignable by the undersigned.

         14. Applicable Law. This Subscription Agreement has been negotiated and
consummated in the State of California and shall be governed by and construed in
accordance  with the laws of the State of  California,  without giving effect to
conflict of laws.

         15. Choice of Jurisdiction. Any action or proceeding arising, directly,
indirectly,  or otherwise,  in connection with, out of or from this Subscription
Agreement, any breach hereof or any transaction covered hereby shall be resolved
within San Francisco, California. Accordingly, the parties consent and submit to
the  jurisdiction  of the United States  federal and state courts located within
San Francisco, California.

         16. Taxpayer  Identification  Number.  The  undersigned  verifies under
penalties of perjury that any Taxpayer  Identification Number or Social Security
Number shown on the signature page hereto is true, correct, and complete.

         17. Pronouns. Any personal pronoun shall be considered to mean the
corresponding  masculine,  feminine,  or neuter personal pronoun, as the context
requires.

                                       9
<PAGE>

    IN WITNESS WHEREOF, the undersigned has executed this Subscription Agreement
this __ day of ___________, 1999.

Number of Units Subscribed for: ________ Units

INDIVIDUAL SUBSCRIBER:                      ENTITY SUBSCRIBER:


______________________________________      ____________________________________
(Signature of Subscriber)                   (Print Name of Subscriber)


______________________________________      By: ________________________________
(Typed or Printed Name
)                                           Name: ______________________________

                                            Title: _____________________________

______________________________________      ____________________________________
(Residence Address)                         (Address)

______________________________________      ____________________________________
(City, State and Zip Code)                  (City, State and Zip Code)

______________________________________      ____________________________________
(Telephone Number)                          (Telephone Number)

______________________________________      ____________________________________
(Telecopier Number)                         (Telecopier Number)

______________________________________      ____________________________________
(Tax I.D. or Social Security Number)        (Tax I.D. or Social Security Number)


ACCEPTED:

NEUROBIOLOGICAL TECHNOLOGIES, INC.

By: ________________________________________
Name:  Paul Freiman
Title: Chief Executive Officer and President

Date:  ________________________, 1999


                                       10
<PAGE>

                                   Schedule A


Subsequent to June 30, 1999,  the Company  issued 195,950 shares of Common Stock
and Warrants to purchase 78,380 shares of Common Stock in a private financing.




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