NEUROBIOLOGICAL TECHNOLOGIES INC /CA/
DEF 14A, 2000-10-16
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 14A
                                 (RULE 14A-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

      PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES EXCHANGE
                           ACT OF 1934 (AMENDMENT NO.)

     Filed by the  Registrant /X/
     Filed by a Party other than the Registrant / /
     Check the appropriate box:

     / / Preliminary Proxy Statement           / / Confidential, for Use of the
     /X/ Definitive Proxy Statement                Commission Only (as permitted
     / / Definitive Additional Materials           by Rule 14a-6(e)(2))
     / / Soliciting Material Under Rule 14a-12

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
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                (Name of Registrant as Specified in its Charter)

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    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

     /X/ No fee required.

     / / Fee computed on table below per Exchange  Act Rules  14a-6(i)(1)  and
         0-11.

     (1) Title of each class of securities to which transaction applies:

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     (2) Aggregate number of securities to which transaction applies:

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     (3) Per unit  price  or other  underlying  value  of  transaction  computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee
is calculated and state how it was determined):

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     (4) Proposed maximum aggregate value of transaction:

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     (5) Total fee paid:

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     / / Fee paid previously with preliminary materials:

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     / / Check box if any part of the fee is offset as provided by Exchange  Act
Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

     (1) Amount Previously Paid:

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     (2) Form, Schedule or Registration Statement No.:

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     (3) Filing Party:

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     (4) Date Filed:

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<PAGE>

                               [GRAPHIC OMITTED]

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                           3260 Blume Drive, Suite 500
                           Richmond, California 94806
                                 (510) 262-1730

                                October 16, 2000

Dear Stockholder:

     You  are  cordially invited to attend the Annual Meeting of Stockholders of
Neurobiological  Technologies,  Inc.  The Annual Meeting will be held at the St.
Francis  Yacht Club, On The Marina, in San Francisco, California on November 21,
2000 at 10 a.m.

     The  formal  notice of the Annual Meeting and the Proxy Statement have been
made a part of this invitation.

     At  your  earliest  convenience  and after you have read the enclosed Proxy
Statement,  please  mark,  date  and  sign  the enclosed proxy and return in the
enclosed  prepaid  envelope  addressed  to ChaseMellon Shareholder Services, our
transfer  agent,  to  ensure  that  your shares will be represented. YOUR SHARES
CANNOT  BE  VOTED  UNLESS YOU SIGN, DATE AND RETURN THE ENCLOSED PROXY OR ATTEND
THE ANNUAL MEETING IN PERSON.

     A copy of the Company's Annual Report on Form 10-KSB is also enclosed.

     The Board of  Directors  and  Management  look forward to seeing you at the
Annual Meeting.

                                     Sincerely yours,

                                     /s/ Paul E. Freiman

                                     Paul E. Freiman
                                     President and Chief Executive Officer

<PAGE>

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.

                              ---------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                      TO BE HELD TUESDAY, NOVEMBER 21, 2000

                              ---------------------

THE STOCKHOLDERS OF NEUROBIOLOGICAL TECHNOLOGIES, INC.:

     The  Annual  Meeting  of Stockholders of Neurobiological Technologies, Inc.
("NTI"  or  the  "Company")  will  be held at the St. Francis Yacht Club, On The
Marina,  San Francisco, California, on November 21, 2000 at 10 a.m., local time,
for the following purposes:

     1.  To elect six directors to hold office until the next annual  meeting of
         stockholders and until their successors are elected.

     2.  To approve an amendment to the Company's  Amended and Restated Employee
         Stock Purchase Plan to increase the number of shares issuable under the
         plan by 150,000 to a total of 300,000 shares.

     3.  To  approve an  amendment  to the  Company's  Restated  Certificate  of
         Incorporation  to  increase  the  number  of  authorized  shares of the
         Company's common stock by 10,000,000 to a total of 35,000,000 shares.

     4.  To  ratify  the  appointment  of  Ernst  & Young  LLP as the  Company's
         independent auditors.

     5.  To transact such other business as properly may come before the meeting
         or any adjournments or postponements of the meeting.

     The  foregoing  items  of  business  are  more fully described in the Proxy
Statement accompanying this Notice.

     Only  stockholders  of  record  at the close of business on October 2, 2000
are  entitled  to  notice  of,  and  to  vote  at,  the  Annual  Meeting and any
adjournments  or  postponements  of the meeting. A complete list of stockholders
entitled  to  notice  of  and to vote at the Annual Meeting will be available at
the  Company's  offices,  3260 Blume Drive, Suite 500, Richmond, California, for
ten days before the meeting.

     All  stockholders  are  cordially  invited to attend the meeting in person.
However,  to  assure  your representation at the meeting, you are urged to mark,
sign,  date and return the enclosed proxy as promptly as possible in the postage
prepaid  envelope  enclosed  for  that  purpose.  Any  stockholder attending the
meeting may vote in person even if he or she returned a proxy.

                                     By Order of the Board of Directors,

                                     /s/ Paul E. Freiman

                                     Paul E. Freiman
                                     President and Chief Executive Officer
Richmond, California
October 16, 2000

--------------------------------------------------------------------------------

                                   IMPORTANT
  WHETHER  OR  NOT  YOU  EXPECT TO ATTEND THE MEETING IN PERSON, PLEASE SIGN AND
  RETURN  THE  ENCLOSED  PROXY  AS  SOON  AS  POSSIBLE IN THE ENCLOSED POST-PAID
  ENVELOPE. THANK YOU FOR ACTING PROMPTLY.

--------------------------------------------------------------------------------

<PAGE>

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                           3260 BLUME DRIVE, SUITE 500
                               RICHMOND, CA 94806
                                 (510) 262-1730

                              ---------------------

                                 PROXY STATEMENT

                              ---------------------

     The  enclosed  proxy  is solicited on behalf of the Board of Directors (the
"Board")  of  Neurobiological  Technologies, Inc., a Delaware corporation ("NTI"
or  the  "Company").  The  proxy  is  solicited for use at the Annual Meeting of
Stockholders  (the  "Annual  Meeting") to be held at the St. Francis Yacht Club,
On  The  Marina,  in San Francisco, California, on November 21, 2000 at 10 a.m.,
local  time,  and  at  any  and  all  adjournments or postponements thereof. The
approximate  date  on which this proxy statement and the accompanying notice and
proxy are being mailed to stockholders is October 16, 2000.

                 INFORMATION CONCERNING SOLICITATION AND VOTING

     Only  stockholders  of  record  at the close of business on October 2, 2000
are  entitled  to  notice  of,  and  to  vote  at,  the  Annual  Meeting and any
adjournments  or  postponements  thereof. At the close of business on October 2,
2000,  the  Company had outstanding 16,311,278 shares of Common Stock, par value
$.001  per  share  ("Common  Stock")  and 2,182,000 shares of Series A Preferred
Stock,  par  value  $.001  per  share (the "Preferred Stock"). Holders of Common
Stock  are  entitled to one vote for each share of Common Stock held. Holders of
Preferred  Stock  are  entitled one vote for each share of Preferred Stock held.
The  holders  of Common Stock and Preferred Stock will vote together as a single
class  on  all matters described in this proxy statement. In order to constitute
a  quorum  for  the conduct of business at the Annual Meeting, a majority of the
outstanding  shares  entitled  to vote at the Annual Meeting must be represented
at the Annual Meeting.

     All  shares represented by each properly executed, unrevoked proxy received
in  time  for  the  Annual  Meeting will be voted in the manner specified in the
proxy.  If  the  manner of voting is not specified in an executed proxy received
by  the  Company,  the  proxy  will  be  voted for the election of the directors
listed  in  the  proxy  for  election to the Board and for approval of the other
proposals described in this proxy statement.

     Directors  are  elected  by a plurality vote. The proposed amendment to the
Company's  Restated  Certificate  of  Incorporation  to  increase  the number of
authorized  shares  of  Common  Stock requires the approval of a majority of the
shares  entitled  to  vote  on  the  amendment.  All other matters submitted for
stockholder  approval  at  the Annual Meeting will be decided by the affirmative
vote  of  a  majority of shares present in person or represented by proxy at the
Annual  Meeting  and  entitled  to  vote  on  each  such  matter.  Votes will be
tabulated  as  follows: (1) abstentions are treated as votes against a proposal;
(2)  executed  proxies are voted as indicated on the proxy; (3) executed proxies
with  no  preferences  are  treated  as  votes  for  a  proposal; and (4) broker
non-votes  are  treated as votes against the proposal to increase the authorized
number  of  shares  of Common Stock, but have no effect on the vote on the other
proposals.  A  broker  non-vote occurs when a broker lacks the authority to vote
on  some  proposals.  Abstentions and broker non-votes are counted as present or
represented  at  the Annual Meeting for purposes of determining whether a quorum
is present.

     Any  stockholder  giving  a  proxy  in  the  form  accompanying  this proxy
statement  has  the power to revoke the proxy prior to its exercise. A proxy can
be  revoked  by  delivering  an  instrument  of  revocation  prior to the Annual
Meeting  to  the  Company,  by  presenting at the Annual Meeting a duly executed
proxy  bearing  a  later  date  or time than the date or time of the proxy being
revoked,  or  at  the Annual Meeting if the stockholder is present and elects to
vote  in  person. Mere attendance at the Annual Meeting will not serve to revoke
a proxy.

<PAGE>

     The  expense  of  printing and mailing proxy materials will be borne by the
Company.  In  addition  to the solicitation of proxies by mail, solicitation may
be  made  by  certain  directors, officers and other employees of the Company by
personal  interview,  telephone or facsimile. No additional compensation will be
paid  to  such  persons  for  such  solicitation.  The  Company  will  reimburse
brokerage   firms  and  others  for  their  reasonable  expenses  in  forwarding
solicitation materials to beneficial owners of the Company's stock.

                                   PROPOSAL 1

                              ELECTION OF DIRECTORS

Nominees

     The  Board  of  Directors  proposes  the  election  of  the  following  six
directors  of  the Company. Directors are elected to serve until the next annual
meeting  of  stockholders  and until their successors are elected and qualified.
The  nominees  securing  the  highest  number  of  votes,  up  to  the number of
directors  to  be  elected,  will  be  elected as directors. It is intended that
proxies  received  will  be  voted  FOR the election of the nominees named below
unless  marked  to  the  contrary.  In  the  event  any such person is unable or
unwilling  to  serve as a director, proxies may be voted for substitute nominees
designated  by the present Board. The Board has no reason to believe that any of
the  persons  named  below will be unable or unwilling to serve as a director if
elected.

<TABLE>
     All  six  nominees  are  currently serving as directors of the Company. The
following  table  indicates  the  name and age of each nominee as of the date of
this  proxy  statement,  all positions with the Company held by the nominee, and
the year during which the nominee first was elected or appointed a director.

<CAPTION>
                                                                                     Director
                                                                                   Continuously
              Name                  Age              Position with NTI                Since
--------------------------------   -----   ------------------------------------   -------------
<S>                                 <C>    <C>                                        <C>
Paul E. Freiman ................    66     President, Chief Executive Officer         1997
                                           and
                                           Director
Abraham E. Cohen ...............    64     Chairman of the Board of Directors         1993
Enoch Callaway, M.D. ...........    76     Director                                   1987
Theodore L. Eliot, Jr. .........    72     Director                                   1992
Abraham D. Sofaer ..............    62     Director                                   1997
John B. Stuppin ................    67     Director                                   1988
</TABLE>

     Paul  E.  Freiman  joined  the  Company as a director in April 1997 and was
elected  President  and  Chief  Executive  Officer in May 1997. He is the former
chairman  and  chief  executive  officer  of  Syntex  Corporation.  Mr.  Freiman
currently  serves as chairman of the boards of Digital GeneTechnologies, Inc., a
private  genomics  company, and SciGen Pte. Ltd. Mr. Freiman currently serves on
the  boards  of  Penwest  Pharmaceutical  Co.,  Calypte  Biomedical Corporation,
Omware,  Inc., PHYTOS, Inc. and Otsuka America Pharmaceuticals, Inc. He has been
chairman  of  the  Pharmaceutical  Manufacturers Association of America (PhARMA)
and  has  also chaired a number of key PhARMA committees. Mr. Freiman is also an
advisor  to  Burrill  &  Co., a San Francisco merchant bank. Mr. Freiman holds a
B.S.  degree from Fordham University and an honorary doctorate from the Arnold &
Marie Schwartz College of Pharmacy.

     Abraham  E.  Cohen  has been a director of the Company since March 1993 and
has  been  Chairman  of  the  Board of Directors since August 1993. From 1982 to
1992,  Mr. Cohen served as senior vice president of Merck & Co. and from 1977 to
1988  as  President of the Merck Sharp & Dohme International Division. Since his
retirement  from Merck and MSDI in January 1992, Mr. Cohen has been active as an
international business consultant. He was a director of Agouron

                                        2

<PAGE>

Pharmaceuticals,  Inc.  until  its  merger  with  Warner-Lambert  Company. He is
currently  a  director of seven other public companies: Akzo Nobel N.V., Axonyx,
Inc.,  Chugai  Pharmaceutical  Co.,  Pharmaceutical  Product  Development, Inc.,
Smith   Barney   Mutual   Funds,   Teva   Pharmaceutical  Industries,  Ltd.  and
Vasomedical,  Inc.  Additionally,  he  serves  as  a  Trustee  on The Population
Council.

     Enoch  Callaway,  M.D.  is a founder and former employee of the Company and
has  served  as  a  director  of  the Company since September 1987. Dr. Callaway
previously  served  as  Chairman  of  the Board of Directors of the Company from
September  1987  to  November  1990,  as Co-Chairman of the Board of the Company
from  November  1990  until  August  1993, as Vice President of the Company from
September  1988 until August 1993 and as Secretary of the Company from September
1988  until  September  1991.  Dr.  Callaway  has  been  Emeritus  Professor  of
Psychiatry  at  the University of California, San Francisco since 1986, where he
also  served as Director of Research at the Langley Porter Psychiatric Institute
from  1959  to  1986.  Dr.  Callaway was Staff Psychiatrist, SFVAMC from 1996 to
1997.  He  is  a  member of the IRB for SAM Technologies, Inc. and Abratek, Inc.
Dr.  Callaway  is a director of Phytos, Inc. He holds A.B. and M.D. degrees from
Columbia University.

     Theodore  L.  Eliot,  Jr.  has  served  as  a director of the Company since
August  1992.  Previously, he served as a director of the Company from September
1988  until  April  1992,  and as a Vice President of the Company from September
1988  until  September 1991. Mr. Eliot retired from the United States Department
of  State  in  1978,  after  a  30-year  career in which he held senior posts in
Washington  and  was  Ambassador  to  Afghanistan.  He  was Dean of the Fletcher
School  of  Law  and  Diplomacy from 1978 to 1985 and a director of Raytheon Co.
from  1983  to  1998.  He  is  currently  a  director of Fiberstars, Inc. and of
several  non-profit  organizations. Mr. Eliot holds B.A. and M.P.A. degrees from
Harvard University.

     Abraham  D.  Sofaer  has  served  as  a director of the Company since April
1997.  Mr.  Sofaer  is the first George P. Shultz Distinguished Scholar & Senior
Fellow  at  the  Hoover  Institution, Stanford University, appointed in 1994. He
has  also  been  a  Professor  of Law (by courtesy) at Stanford Law School since
1997.  From  1990 to 1994, Mr. Sofaer was a partner at the legal firm of Hughes,
Hubbard  and  Reed  in Washington, D.C., where he represented several major U.S.
public  companies.  From  1985  to  1990,  he served as the Legal Adviser to the
United  States Department of State, where he was principal negotiator on several
international  disputes.  From 1979 to 1985, he served as a federal judge in the
Southern  District  of  New  York.  Mr.  Sofaer  is  registered  as  a qualified
arbitrator  with  the  American  Arbitration  Association and is a member of the
National  Panel of the Center for Public Resolution of Disputes (CPR), a leading
organization  in  the  area of resolution of disputes outside litigation. He has
mediated   major  commercial  cases.  Additionally,  he  acts  regularly  as  an
arbitrator  in merger-acquisition disputes, commercial cases involving valuation
of  technology,  and  securities  class  action  suits.  Mr.  Sofaer  is  on the
International  Advisory  Board of Chugai Biopharmaceuticals, Inc., a director of
Koret  Israel  Economic Development Fund and a trustee of the National Museum of
Jazz.  Mr. Sofaer holds a B.A. degree from Yeshiva College and a L.L.B. from New
York University.

     John  B. Stuppin is a founder and employee of the Company and has served as
a  director  of  the  Company  since  September  1988. From September 1987 until
October  1990,  Mr.  Stuppin  served  as President of the Company, from November
1990  to August 1993 as Co-Chairman of the Board of Directors, from October 1990
until  September  1991  as  Executive  Vice President, and from April 1991 until
July  1994 as Treasurer. He also served as acting Chief Financial Officer of the
Company  from  the  Company's inception through December 1993. Mr. Stuppin is an
investment  banker  and a venture capitalist. He has over 25 years experience in
the  start  up  and  management of companies active in emerging technologies and
has  been  the president of a manufacturing company. He is chairman of the board
of Fiberstars, Inc. Mr. Stuppin holds an A.B. degree from Columbia College.

     The  Board  of  Directors  recommends a vote "FOR" election of the nominees
set forth above.

                                       3

<PAGE>

Board Meetings and Committees

     The  Board  of  Directors  held  nine meetings during the fiscal year ended
June  30,  2000.  All directors attended at least 75% of the aggregate number of
meetings  of  the  Board  of Directors and of committees on which such directors
serve.

     The  Board  of  Directors  has appointed a Compensation Committee, an Audit
Committee and a Nominating Committee.

     The  members  of  the Compensation Committee are Theodore L. Eliot, Jr. and
Abraham  D.  Sofaer. The Compensation Committee held four meetings during fiscal
2000.   The   Compensation   Committee's   functions   are   to  assist  in  the
implementation  of,  and  provide  recommendations  with respect to, general and
specific  compensation  policies  and  practices  of  the Company, including the
administration  of  and  granting of options under the Company's 1993 Stock Plan
and Amended and Restated Employee Stock Purchase Plan.

     The members of the Audit Committee are Theodore L. Eliot,  Jr.,  Abraham E.
Cohen, and Abraham D. Sofaer.  Each member is  "independent"  under the National
Association of Securities Dealers' listing standards. The Board of Directors has
adopted a charter  for the Audit  Committee  in the form  attached to this proxy
statement  as Appendix B. The Audit  Committee  held one meeting  during  fiscal
2000.  The Audit  Committee's  functions  are to review  the scope of the annual
audit, monitor the independent auditor's  relationship with the Company,  advise
and assist the Board of  Directors  in  evaluating  the  auditor's  examination,
supervise the  Company's  financial and  accounting  organization  and financial
reporting and recommend for approval by the Board of Directors and  ratification
at the Annual Meeting a firm of certified public accountants whose duty it is to
audit the  financial  records of the Company for the fiscal year for which it is
appointed.  The Audit Committee has reviewed and discussed the audited financial
statements  with the Company's  management  team,  discussed  with the Company's
independent  auditors all matters pursuant to SAS 61 (Codification of Statements
on  Auditing  Standards,  AU ss. 380) and  received a report from the  Company's
independent  auditors with respect to the financial  statements and disclosures.
The Audit Committee has also received and reviewed the letter from the Company's
independent auditors required by Independence Standards Board Standard No. 1 and
discussed with the auditors their independence from the Company.  Based upon all
such reviews and  discussions,  recommended  to the Board of Directors  that the
audited financial  statements be included in the Company's Annual Report on Form
10-KSB for the fiscal year ended June 30,  2000 for filing  with the  Securities
and Exchange Commission.

                                     Abraham E. Cohen, Chairman
                                     Thomas L. Eliot, Jr.
                                     Abraham D. Sofaer

     The  members of the Nominating Committee are Dr. Enoch Callaway and John B.
Stuppin.  The  Nominating  Committee  held  no  meetings during fiscal 2000. The
Nominating  Committee  is responsible for matters relating to the composition of
the  Board  of  Directors,  including recruitment, nomination and succession. No
nominations  were  received  from  stockholders,  and  no  procedures  have been
established for any such nominations.

Directors' Compensation

     Dr.  Callaway  was  paid $15,000 during fiscal 2000 for consulting services
rendered  to  the  Company  pursuant  to a consulting agreement. Mr. Stuppin was
paid  $13,008  during  fiscal  2000  as an employee of the Company. Mr. Cohen is
reimbursed for his expenses for each meeting attended.

                                        4

<PAGE>

     Non-employee  directors  are  currently  eligible  to  participate  in  the
Company's   1993   Stock  Plan.  Subject  to  the  1993  Stock  Plan,  each  new
non-employee  director  of  the Company will receive an option to purchase 5,000
shares  of  Common Stock on the date of his or her election to the Board with an
exercise  price  equal  to the fair market value of the Common Stock on the date
of  grant.  In  addition,  each non-employee director continuing to serve on the
Board  will  also  receive  an  automatic  annual grant of an option to purchase
1,000  shares  of  Common  Stock  after  each  annual  meeting  of the Company's
stockholders.

     In  December  1999,  Mr. Freiman was granted a nonqualified stock option to
purchase  150,000  shares  of  Common  Stock  at  an exercise price of $0.80 per
share.  The  option  vests  in  full  on  December  2004 or earlier, in whole or
inpart, in the event of a change of control of the Company.

     In  May,  2000,  Dr. Callaway and Messrs. Cohen, Eliot and Sofaer were each
granted  an option to purchase 20,000 shares of Common Stock and Mr. Stuppin was
granted  an option to purchase 50,000 shares of Common Stock, all at an exercise
price  of  $6.188 per share. The options vest over four years in accordance with
the  Company's standard vesting policy and become fully exercisable in the event
of  a  change  of  control as defined in the Company's Amended and Restated 1993
Stock Plan.

                                        5

<PAGE>

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

<TABLE>
     The   following  table  sets  forth  information  regarding  the  Company's
outstanding  shares  of each class of equity securities beneficially owned as of
October  2,  2000  by:  (1)  each  person  who  is  known  to the Company to own
beneficially  more  than  five  percent  of each class of the outstanding equity
securities;  (2)  each of the Company's directors; (3) the officers named in the
Summary  Compensation  Table below; and (4) all directors and executive officers
as  a  group.  The  information  relating  to  share  ownership  is  based  upon
information  furnished  to  the  Company.  The  number of shares of Common Stock
beneficially  owned  by an individual as reported in the second column below, as
well  as  the  number  of shares of Common Stock deemed outstanding in computing
such  individual's  percentage ownership as reported in the fourth column below,
includes  shares  of  Common Stock issuable upon conversion of shares subject to
warrants  or options exercisable within 60 days after October 2, 2000 as if such
shares  were outstanding on October 2, 2000, but does not include shares subject
to  any  other  warrants  or  options.  The Company believes that the beneficial
owners  of  each  class  of  equity securities, based on information supplied by
such  owners,  have  sole investment and voting power with respect to the shares
of  each  class  of equity securities shown as being beneficially owned by them,
except as otherwise set forth in the footnotes to the table.

<CAPTION>
                                                               Number
                                                             Subject to
                                                             Options and                        Number of        Percentage
                                            Number of         Warrants        Percentage        Shares of        of Series A
                                            Shares of        Exercisable       of Common         Series A         Preferred
            Name and Address              Common Stock     Within 60 days        Stock       Preferred Stock        Stock
---------------------------------------- --------------   ----------------   ------------   -----------------   ------------
<S>                                         <C>                 <C>               <C>            <C>                 <C>
Lindsay A. Rosenwald, M.D. (1) .........    1,759,500           500,000           10.5%               --               --
 787 Seventh Avenue, 48th Floor
 New York, NY 10019
Arthur Rock (2) ........................    1,185,997           436,071            7.1           500,000             22.9%
 One Maritime Plaza, #1220
 San Francisco, CA 94111
New York Life Insurance
 Company (3) ...........................      553,750                --            3.4           400,000             18.3
 51 Madison Avenue, Room 206
 New York, NY 10010
Clipperbay & Co. .......................      900,000                --            5.5                --               --
 55 Water Street, 3rd Floor
 New York, NY 10041
Paul E. Freiman (4) ....................      380,075           324,375            2.3                --               --
Enoch Callaway, M.D. (5) ...............      136,990            37,742              *             4,000                *
Abraham E. Cohen .......................      576,391           306,554            3.5           100,000              4.6
Theodore L. Eliot, Jr. (6) .............       86,660            59,116              *                --               --
Abraham D.Sofaer .......................      569,431           291,504            3.4           100,000              4.6
John B. Stuppin (7) ....................      675,431             6,250            4.1           100,000              4.6
Lisa U. Carr, M.D., Ph.D. ..............       43,568            32,021              *                --               --
All directors and executive officers
 (as a group 7 persons) (8) ............    2,468,546         1,057,562           14.2           304,000             13.9

<FN>
------------

* Less than 1%

(1) According to Schedule 13G dated  February 8, 2000 and Form 4 dated June 2000
    filed by Lindsay A. Rosenwald, M.D.

(2) According  to Schedule  13D/A filed by Arthur Rock on November  19, 1999 and
    the Company's records.

(3) According  to  Schedule  13G filed by New York  Life  Insurance  Company  on
    February 12, 1997.

(4) The number of shares of common stock shown  includes  55,700  shares held in
    the estate of Paul E. Freiman and Anna Mazzuchi Freiman.

(5) The number of shares of common stock shown  includes  99,248  shares held by
    Enoch  Callaway and Dorothy C. Callaway,  Trustees or Successor  Trustees of
    the Callaway 1989 Trust,  executed May 20, 1989. Dr.  Callaway may be deemed
    to have a beneficial interest in the shares held by the Callaway Trust.

                                        6

<PAGE>

(6) The number of shares of common stock shown  includes  27,544  shares held by
    Theodore L. Eliot,  Jr. and  Patricia P. Eliot,  Trustees,  the Eliot Trust,
    February 27, 1987. Mr. Eliot may be deemed to have a beneficial  interest in
    the shares held by the Eliot Trust.

(7) The number of shares of common stock shown  includes  667,681 shares held by
    John B. Stuppin and Jane K.  Stuppin,  Trustees UTD dated March 11, 1991 and
    500  shares  held by Mrs.  Stuppin.  Mr.  Stuppin  may be  deemed  to have a
    beneficial  interest  in the  shares  held by the  Stuppin  Trust  and  Mrs.
    Stuppin.

(8) The number of shares of common stock shown includes shares included pursuant
    to notes 4-7.
</FN>
</TABLE>

Executive Compensation

<TABLE>
     The  following  table sets forth information regarding compensation for the
fiscal  years ended June 30, 1998, 1999 and 2000 received by the Company's Chief
Executive  Officer  during  fiscal  2000  and  the  Company's  other most highly
compensated  executive  officer  whose  total annual salary and bonus for fiscal
year 2000 exceeded $100,000 (the "Named Officers").

                          Summary Compensation Table

<CAPTION>
                                                                                    Long-Term
                                                Annual Compensation            Compensation Awards
   Name and Principal Position as of     ----------------------------------   --------------------
             June 30, 2000                Year     Salary ($)     Bonus($)         Options(#)
--------------------------------------   ------   ------------   ----------   --------------------
<S>                                      <C>         <C>             <C>             <C>
Paul E. Freiman ......................   2000        155,055         0               225,000
 President and Chief Executive Officer   1999        152,527         0               200,000
                                         1998         92,533         0               250,000
Lisa U. Carr, M.D., Ph.D.(1) .........   2000        102,743         0                52,500
 Vice President, Medical Affairs         1999        104,360         0               100,000
                                         1998          8,333         0                     0

<FN>
------------

(1) Dr. Carr joined the Company on June 1, 1998. Fiscal 1998 compensation is for
    partial year.
</FN>
</TABLE>

<TABLE>
     The following table sets forth further information  regarding the grants of
stock options during the fiscal year ended June 30, 2000 to the Named  Officers.
Since  inception,  the Company has not  granted any stock  appreciation  rights.

                          Option Grants in Fiscal 2000

<CAPTION>
                                                               Individual Grant
                                      -------------------------------------------------------------------
                                                             Percent of
                                          Number of        Total Options
                                         Securities           Granted
                                         Underlying       to Employees in      Exercise or
                                           Options             Fiscal          Base Price      Expiration
                Name                   Granted (#)(1)        2000(%)(2)       ($/Share)(1)        Date
-----------------------------------   ----------------   -----------------   --------------   -----------
<S>                                        <C>                   <C>               <C>          <C>
Paul E. Freiman ...................        150,000(3)            38.8              0.80         12/3/09
                                            75,000(4)            19.4              6.188        5/17/10
Lisa U. Carr, M.D., Ph.D. .........         12,500(4)             3.2              0.891        9/28/09
                                            40,000(4)            10.3              6.188        5/17/10

<FN>
------------

(1) The options were granted under the Company's Amended and Restated 1993 Stock
    Plan. The exercise  price of all the options,  other than the option granted
    to Mr.  Freiman to purchase  150,000  shares,  was equal to 100% of the fair
    market value on the date of grant. The fair market value of the Common Stock
    on December 3, 1999, the date on which Mr. Freiman was granted the option to
    purchase 150,000 shares, was $2.56.

(2) Based on a total of 387,000 stock options granted to employees during fiscal
    year ended June 30, 2000.

(3) These  options  become  exercisable  five  years  from  the date of grant or
    earlier, in whole or in part, upon a change of control of the Company.

(4) The options vest 12.5% six months after the date of grant and 2.08%  monthly
    thereafter.
</FN>
</TABLE>

     Both  of  the  Named  Officers  exercised  options  during fiscal 2000. The
following  table  sets  forth  information  regarding  the  number  and value of
unexercised options held by the Named Officers at fiscal year-end.

                                        7

<PAGE>

<TABLE>
                    Aggregated Option Exercises and Fiscal Year-End Option Values in Last Fiscal Year

<CAPTION>
                                                                                                   Value of Unexercised
                                       Number of                 Number of Unexercised Options     In-the-Money Options
                                        Shares                     Held at Fiscal Year End(#)    at Fiscal Year End($)(1)
                                      Acquired on      Value     ----------------------------- ----------------------------
                Name                 Exercise (#)   Realized($)   Exercisable   Unexercisable   Exercisable   Unexercisable
----------------------------------- -------------- ------------- ------------- --------------- ------------- --------------
<S>                                    <C>           <C>           <C>             <C>           <C>           <C>
Paul E. Freiman ...................    60,000        356,220       760,000         495,000       1,800,250     3,278,730
Lisa U. Carr, M.D., Ph.D. .........    38,375        229,051       114,125          99,031         118,242       554,648

<FN>
------------

(1) Based  on  the  amount,  if  any,  by  which the last per share quote of the
    Common  Stock  on  the  OTC  Bulletin Board on June 30, 2000 ($8.50) exceeds
    the exercise price.
</FN>
</TABLE>

Section 16(a) Beneficial Ownership Reporting Compliance

     Under  the  Securities  Exchange  Act  of  1934,  as amended, the Company's
directors,  executive  officers  and  any  persons  holding more than 10% of the
Company's  Common  Stock  are  required to report their initial ownership of the
Company's  Common  Stock  and  any  subsequent  changes in that ownership to the
Securities  and  Exchange  Commission. Specific due dates for these reports have
been  established,  and  the  Company  is  required  to  identify  in this Proxy
Statement  those  persons who failed to timely file these reports. During fiscal
2000,  Mr.  Freiman  failed  to  file a timely Form 5 with respect to the option
granted  to  him  in  December  1999.  A Form 5 reporting the grant was filed in
September  2000.  The  Company  believes  all  other  required reports have been
timely  filed.  In  making  this  disclosure,  the  Company has relied solely on
written  representations  of  its directors and executive officers and copies of
the reports that have been filed with the Commission.

                                  PROPOSAL 2

                         APPROVAL OF AMENDMENT OF THE
               AMENDED AND RESTATED EMPLOYEE STOCK PURCHASE PLAN

     The  Neurobiological Technologies, Inc. Amended and Restated Employee Stock
Purchase  Plan  (the  "ESPP")  was adopted by the Board of Directors on December
15,  1993 and approved by the stockholders in January 1994. As of June 30, 2000,
an  aggregate  of  150,000 shares were authorized for issuance and 33,133 shares
remained available for future purchases under the ESPP.

Summary of Amendment

     On  September  8, 2000, the Board of Directors approved an amendment to the
ESPP  to  increase  the number of shares reserved for purchase under the ESPP by
up  to  150,000  to  up  to  300,000,  subject  to the approval of the Company's
stockholders  at  the  annual  meeting.  The  Board  of  Directors  subsequently
approved  an  amendment  increasing  the  maximum  number  of shares that may be
purchased  by  a  participant  during  a six-month purchase period from 2,500 to
10,000.  The  ESPP,  as amended, is attached to this proxy statement as Appendix
A.

Description of Amended and Restated Employee Stock Purchase Plan

     Under  the  ESPP,  an  aggregate  of  300,000 shares of Common Stock (which
number  includes  the  150,000  share  increase  that the stockholders are being
asked  to  approve)  have  been reserved for issuance. As of June 30, 2000, nine
employees   were  eligible  to  participate  in  the  ESPP.  Eligible  employees
participate  in  the  ESPP  by  authorizing  payroll  deductions  of  any  whole
percentage,   not  less  than  1%  nor  more  than  10%,  of  their  total  cash
compensation.  No  employee is permitted to purchase Common Stock under the ESPP
at  a  rate  which  exceeds  $25,000 of Common Stock valued at fair market value
(determined  at  the time the participant's rights are granted) per year. At the
end  of  each six month period, the Company will apply the amount contributed by
the  participant  during that period to purchase up to a maximum of 10,000 whole
shares of Common Stock.

                                        8

<PAGE>

     All  employees  who have been employed by the Company for three consecutive
months  and  are  customarily  employed 20 or more hours a week and five or more
months  each year are eligible to participate in the ESPP. Any eligible employee
may  enroll  in the ESPP by executing the enrollment form no later than one week
prior  to the last working day prior to the commencement of the offering period.
The  offering  period consists of the 24-month period commencing on each January
1  and  July  1. Shares of Common Stock are purchased at 85% of the lower of (i)
the  market  price  of  Common  Stock  immediately  before  the beginning of the
applicable  offering  period  and  (ii) the market price of such Common Stock at
the time of the purchase.

     The  ESPP  is  administered by the Compensation Committee. The Compensation
Committee  has  the  right  to interpret the ESPP, adopt rules thereunder and to
make  all  other  decisions  relating to the operation of the ESPP. The Board of
Directors  has the right to amend, suspend or terminate the ESPP at any time and
without  notice. All expenses incurred in connection with the implementation and
administration of the ESPP are paid by the Company.

Required Approval

     Approval  of  this  proposal requires the affirmative vote of a majority of
the  shares  present in person or represented by proxy at the Annual Meeting and
entitled to vote on the proposal.

     The  Board  of  Directors  recommends  a  vote  "FOR"  the  adoption of the
amendment of the Company's Amended and Restated Employee Stock Purchase Plan.

                                  PROPOSAL 3

        APPROVAL OF AMENDMENT TO RESTATED CERTIFICATE OF INCORPORATION
                      TO INCREASE AUTHORIZED COMMON STOCK

     On  September  8,  2000,  the  Board  of  Directors unanimously approved an
amendment  to  the  Company's  Restated Certificate of Incorporation to increase
the  number  of  shares  of  authorized  Common  Stock from 25,000,000 shares to
35,000,000  shares.  Of  the  25,000,000  currently  authorized shares of Common
Stock,  as  of  October  2, 2000, 16,311,278 were issued and outstanding. Of the
remaining  8,688,722  authorized shares of Common Stock, 7,920,857 were reserved
for  issuance  in  connection  with  the  Company's  stock option plan and stock
purchase  plan  and  for  issuance upon the exercise of outstanding warrants and
Preferred  Stock. If Proposal 2 amending the ESPP is approved by stockholders at
the  Annual  Meeting, an additional 150,000 shares will be reserved for issuance
under the ESPP.

     Except  for  the increase in shares authorized for issuance under the ESPP,
Company  does  not  have  any  current plan, understanding or agreement to issue
additional  shares  of  Common  Stock.  However,  the  Board  believes  that the
proposed  increase  in authorized shares of Common Stock is desirable to enhance
the  Company's  flexibility  in connection with possible future actions, such as
stock  splits,  stock dividends, corporate mergers and acquisitions, financings,
acquisitions  of  property,  use  in  employee benefit plans, or other corporate
purposes.  The Board will determine whether, when, and on what terms the Company
should  issue  shares  of  Common  Stock in connection with any of the foregoing
purposes.

     The  Company  is subject to restrictions on its ability to issue additional
shares  of  Common  Stock  in  some situations. The Nasdaq Stock Market requires
that  the  Company  obtain stockholder approval before it issues Common Stock in
certain  circumstances,  including when the number of shares to be issued equals
or   exceeds  20%  of  the  voting  power  outstanding.  There  are  many  other
situations,  however,  where  the Board can issue shares of Common Stock without
seeking  the  approval of the stockholders. The issuance of additional shares of
Common  Stock,  other  than  in  connection  with  a  stock  split, could have a
dilutive effect on the stock ownership of current stockholders. Stockholders

                                       9

<PAGE>

do  not have pre-emptive rights to purchase any such Common Stock. Additionally,
the  issuance of shares in certain instances may have the effect of forestalling
a  merger,  tender  offer, proxy contest, assumption of control by a holder of a
large  block  of the Company's stock or the removal of its incumbent management.
The  Board does not intend or view the increase in authorized Common Stock as an
anti-takeover  measure, nor is the Company aware of any proposed or contemplated
takeover transactions.

     Other   than   increasing  the  authorized  shares  of  Common  Stock  from
25,000,000  to  35,000,000,  the  proposed  amendment  in  no  way  changes  the
Company's  Restated  Certificate  of  Incorporation.  The  Board has unanimously
adopted  resolutions  setting  forth  the proposed amendment to the Certificate,
declaring  its  advisability  and  directing  that  the  proposed  amendment  be
submitted  to  the  stockholders  for  their  approval  at the annual meeting on
November  21,  2000.  If  adopted by the stockholders, the amendment will become
effective upon filing as required by the General Corporation Law of Delaware.

Required Approval

     Approval  of  this amendment requires the affirmative vote of a majority of
the  stockholders  eligible  to  vote  at  the  meeting,  whether present at the
meeting or not.

     The  Board  of  Directors  recommends  a  vote  "FOR"  the  adoption of the
amendment  to  the  Company's  Restated Certificate of Incorporation to increase
the authorized shares of Common Stock.

                                   PROPOSAL 4

                      RATIFICATION OF INDEPENDENT AUDITORS

     On  recommendation  of  the  Audit  Committee,  the  Board of Directors has
appointed  the  firm  of Ernst & Young LLP as the Company's independent auditors
for  the  fiscal  year  ended  June  30,  2001,  subject  to ratification by the
stockholders.  Ernst  & Young LLP has audited the Company's financial statements
since  fiscal  1992.  Representatives  of  Ernst  & Young LLP are expected to be
present  at  the Company's Annual Meeting. They will have an opportunity to make
a  statement,  if  they  desire  to  do  so, and will be available to respond to
appropriate questions.

Required Approval

     Approval  of  this  proposal requires the affirmative vote of a majority of
the  shares  present in person or represented by proxy at the Annual Meeting and
entitled to vote on the proposal.

     The  Board  of  Directors  recommends  a vote "FOR" ratification of Ernst &
Young LLP as the Company's independent auditors.

                               OTHER INFORMATION

     A  copy  of  the Company's Annual Report on Form 10-KSB for the fiscal year
ended June 30, 2000 is enclosed with this proxy statement.

                             STOCKHOLDER PROPOSALS

     The  deadline  for  submitting  a stockholder proposal for inclusion in the
Company's  proxy  statement  and  form  of  proxy for the 2001 annual meeting of
stockholders  is  June  15,  2001,  pursuant to Rule 14a-8 of the Securities and
Exchange  Commission.  The  deadline  for submitting a stockholder proposal or a
nomination  for  director that is not to be included in such proxy statement and
proxy  is  August  29,  2001, pursuant to Rule 14a-4(c)(1) of the Securities and
Exchange Commission.

                                       10

<PAGE>

                                 OTHER MATTERS

     The  Company  knows  of  no  other  business  that will be presented at the
Annual  Meeting.  If  any  other  business is properly brought before the Annual
Meeting,  it  is  intended  that  proxies  in the enclosed form will be voted in
accordance with the judgment of the persons voting the proxies.

                                     BY ORDER OF THE BOARD OF DIRECTORS,

                                     /s/ Paul E. Freiman

                                     Paul E. Freiman
                                     President and Chief Executive Officer

Richmond, California
October 16, 2000

     YOU  ARE  CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON. WHETHER OR NOT
YOU  PLAN  TO  ATTEND  THE  MEETING,  YOU  ARE  REQUESTED TO SIGN AND RETURN THE
ACCOMPANYING PROXY IN THE ENCLOSED POSTPAID ENVELOPE.

                                       11

<PAGE>

                                   APPENDIX A

                              AMENDED AND RESTATED
                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                          EMPLOYEE STOCK PURCHASE PLAN
                        (as amended through October 2000)

1. PURPOSE OF THE PLAN.

     The  Plan  was  adopted by the Company's Board of Directors on December 15,
1993,  approved  by  the  Company's stockholders in January 1994 and amended and
restated  by  the  Company's Board of Directors on August 22, 1996, and approved
by the stockholders on November 14, 1996.

     The  purpose  of  the  Plan  is  to  provide  Eligible  Employees  with  an
opportunity  to  increase  their  proprietary  interest  in  the  success of the
Company  by  purchasing Stock from the Company on favorable terms and to pay for
such  purchases  through  payroll  deductions.  The  Plan is intended to qualify
under section 423 of the Internal Revenue Code of 1986, as amended.

2. ADMINISTRATION OF THE PLAN.

     (a)  The  Committee. The  Plan  shall be administered by the Committee. The
interpretation  and  construction  by the Committee of any provision of the Plan
or  of  any  right  to purchase Stock granted under the Plan shall be conclusive
and binding on all persons.

     (b)  Rules  and  Forms. The  Committee may adopt such rules and forms under
the Plan as it considers appropriate.

3. ENROLLMENT AND PARTICIPATION.

     (a)  Offering  Periods. While  the  Plan  is  in  effect,  two  overlapping
Offering  Periods  shall  commence  in  each calendar year. The Offering Periods
shall consist of the 24-month periods commencing on each January 1 and July 1.

     (b)  Accumulation  Periods. While  the  Plan is in effect, two Accumulation
Periods  shall  commence  in  each calendar year. The Accumulation Periods shall
consist of the six-month periods commencing on each January 1 and July 1.

     (c)  Enrollment. Any  individual who, on the day preceding the first day of
an  Offering  Period,  qualifies  as  an Eligible Employee may elect to become a
Participant  in  the  Plan  for such Offering Period by executing the enrollment
form  prescribed for this purpose by the Committee. The enrollment form shall be
filed  with  the  Company  not later than one week prior to the last working day
prior to the commencement of such Offering Period.

     (d)  Duration  of  Participation. Once  enrolled in the Plan, a Participant
shall  continue  to  participate  until  he  or  she  ceases  to  be an Eligible
Employee,  withdraws from the Plan or reaches the end of the Accumulation Period
in  which  he  or she discontinued contributions. A Participant who discontinued
contributions  under  Section  4(d) or withdrew from the Plan under Section 5(a)
may  again  become  a Participant, if he or she then is an Eligible Employee, by
following the procedure described in Subsection (c) above.

     (e)  Applicable  Offering Period.  For purposes of calculating the Purchase
Price  under Section 7(b), the applicable Offering Period shall be determined as
follows:

           (i) Once a  Participant  is  enrolled  in the  Plan  for an  Offering
     Period,  such Offering  Period shall  continue to apply to him or her until
     the earliest of (A) the end of such Offering Period,  (B) the end of his or
     her  participation  under  Subsection  (d) above or (C)  reenrollment  in a
     subsequent Offering Period under Paragraph (ii) below.

                                       A-1

<PAGE>

           (ii) In the  event  that the Fair  Market  Value of Stock on the last
     trading day before the  commencement  of the  Offering  Period in which the
     Participant  is enrolled is higher than on the last  trading day before the
     commencement  of any subsequent  Offering  Period,  the  Participant  shall
     automatically be re-enrolled for such subsequent Offering Period.

           (iii) When a  Participant  reaches the end of an Offering  Period but
     his or her  participation  is to  continue,  then  such  Participant  shall
     automatically  be  re-enrolled  for  the  Offering  Period  that  commences
     immediately after the end of the prior Offering Period.

4. EMPLOYEE CONTRIBUTIONS.

     (a)  Frequency  of Payroll Deductions. A Participant may purchase shares of
Stock  under the Plan solely by means of payroll deductions. Payroll deductions,
as  designated  by the Participant pursuant to Subsection (b) below, shall occur
on each payday during participation in the Plan.

     (b)  Amount  of Payroll Deductions. An Eligible Employee shall designate on
the  enrollment  form  the  portion  of  his  or her Compensation that he or she
elects  to  have  withheld  for  the  purchase of Stock. Such portion shall be a
whole  percentage  of the Eligible Employee's Compensation, but not less than 1%
nor more than 10%.

     (c)  Changing  Withholding Rate. If a Participant wishes to change the rate
of  payroll  withholding,  he  or  she may do so by filing a new enrollment form
with  the Company not later than one week prior to the last working day prior to
the  commencement  of  the  Accumulation  Period  for which such change is to be
effective.

     (d)   Discontinuing   Payroll   Deductions. If   a  Participant  wishes  to
discontinue  employee  contributions  entirely,  he or she may do so by filing a
new  enrollment  form  at  any  time. Payroll withholding shall cease as soon as
reasonably practicable after such form has been received by the Company.

5. WITHDRAWAL FROM THE PLAN.

     (a)  Withdrawal. A  Participant  may  elect  to  withdraw  from the Plan by
filing  the  prescribed form with the Company at any time before the last day of
an  Accumulation  Period.  As soon as reasonably practicable thereafter, payroll
deductions  shall cease and the entire amount credited to the Participant's Plan
Account  shall  be  refunded to him or her in cash, without interest. No partial
withdrawals shall be permitted.

     (b)  Re-Enrollment After Withdrawal. A former Participant who has withdrawn
from  the Plan shall not be a Participant until he or she re-enrolls in the Plan
under Section 3(b).

6. TERMINATION OF EMPLOYMENT OR DEATH.

     (a)  Termination  of  Employment. Termination  of employment as an Eligible
Employee  for  any  reason,  including  death,  shall be treated as an automatic
withdrawal  from the Plan under Section 5(a). (A transfer from one Participating
Company to another shall not be treated as a termination of employment.)


     (b)  Death. In the event of the Participant's death, the amount credited to
his  or her Plan Account shall be paid to a beneficiary designated by him or her
for  this  purpose  on  the  prescribed  form  or, if none, to the Participant's
estate.  Such  form  shall be valid only if it was filed with the Company before
the Participant's death.

7. PLAN ACCOUNTS AND PURCHASE OF SHARES.

     (a)  Plan  Accounts. The Company shall maintain a Plan Account on its books
in  the  name  of  each  Participant.  Whenever  an  amount is deducted from the
Participant's  Compensation under the Plan, such amount shall be credited to the
Participant's Plan Account. No interest shall be credited to Plan Accounts.

                                       A-2

<PAGE>

     (b)  Purchase  Price. The  Purchase Price for each share of Stock purchased
at the close of an Accumulation Period shall be the lower of:

         (i) 85% of the Fair Market  Value of such share on the last trading day
     before the  commencement  of the applicable  Offering Period (as determined
     under Section 3(e)); or

         (ii) 85% of the Fair Market Value of such share on the last trading day
     in such Accumulation Period.

     (c)  Number  of  Shares  Purchased. As of the last day of each Accumulation
Period,  each Participant shall be deemed to have elected to purchase the number
of  shares  of  Stock  calculated in accordance with this Subsection (c), unless
the  Participant  has previously elected to withdraw from the Plan in accordance
with  Section  5(a).  The amount then in the Participant's Plan Account shall be
divided  by  the  Purchase Price, and the number of shares that results shall be
purchased  from  the  Company  with the funds in the Participant's Plan Account.
The  foregoing  notwithstanding,  no  Participant  shall  purchase  more  than a
maximum  of  10,000  shares of Stock with respect to any Accumulation Period nor
shares  of Stock in excess of the amounts set forth in Sections 8 and 12(a). The
Committee  may  determine  with  respect to all Participants that any fractional
share,  as  calculated  under  this Subsection (c), shall be rounded down to the
next lower whole share.

     (d)  Available  Shares Insufficient. In the event that the aggregate number
of  shares that all Participants elect to purchase during an Accumulation Period
exceeds  the  maximum  number  of  shares remaining available for issuance under
Section  12(a),  then the number of shares to which each Participant is entitled
shall  be  determined by multiplying the number of shares available for issuance
by  a  fraction,  the  numerator  of  which  is  the  number of shares that such
Participant  has  elected to purchase and the denominator of which is the number
of shares that all Participants have elected to purchase.

     (e)  Issuance  of  Stock. Certificates  representing  the  shares  of Stock
purchased  by a Participant under the Plan shall be issued to him or her as soon
as  reasonably  practicable  after  the  close  of  the  applicable Accumulation
Period,  except  that the Committee may determine that such shares shall be held
for  each  Participant's benefit by a broker designated by the Committee (unless
the  Participant  has elected that certificates be issued to him or her). Shares
may  be  registered in the name of the Participant or jointly in the name of the
Participant  and  his  or her spouse as joint tenants with right of survivorship
or as community property.

     (f)  Unused  Cash  Balances. An  amount remaining in the Participant's Plan
Account  that  represents  the  Purchase Price for any fractional share shall be
carried  over in the Participant's Plan Account to the next Accumulation Period.
Any  amount  remaining  in  the  Participant's  Plan Account that represents the
Purchase  Price  for  whole  shares  that  could  not  be purchased by reason of
Subsection  (c)  above  or Section 12(a) shall be refunded to the Participant in
cash, without interest.

8. LIMITATIONS ON STOCK OWNERSHIP.

Any  other  provision  of  the  Plan  notwithstanding,  no  Participant shall be
granted a right to purchase Stock under the Plan if:

     (a)  Such  Participant,  immediately  after his or her election to purchase
such  Stock,  would  own  stock  possessing  more  than 5% of the total combined
voting  power  or  value of all classes of stock of the Company or any parent or
Subsidiary of the Company; or

     (b)  Under  the  terms  of  the Plan, such Participant's rights to purchase
stock  under  this  and all other qualified employee stock purchase plans of the
Company  or  any parent or Subsidiary of the Company would accrue at a rate that
exceeds  $25,000  of the fair market value of such stock (determined at the time
when  such  right  is  granted)  for  each calendar year for which such right or
option is outstanding at any time.

                                       A-3

<PAGE>

     Ownership  of  stock  shall  be  determined  after applying the attribution
rules  of  section  424(d) of the Internal Revenue Code of 1986, as amended. For
purposes  of  this  Section  8,  each Participant shall be considered to own any
stock  that  he or she has a right or option to purchase under this or any other
plan,  and  each  Participant  shall be considered to have the right to purchase
10,000  shares  of  Stock  under  this  Plan  with  respect to each Accumulation
Period.

9. RIGHTS NOT TRANSFERABLE.

     The  rights  of  any  Participant  under  the  Plan,  or  any Participant's
interest  in  any  Stock  or moneys to which he or she may be entitled under the
Plan,  shall  not  be  transferable by voluntary or involuntary assignment or by
operation  of  law, or in any other manner other than by beneficiary designation
or  the  laws  of  descent  and  distribution.  If  a  Participant in any manner
attempts  to  transfer,  assign  or  otherwise  encumber  his  or  her rights or
interest  under  the  Plan, other than by beneficiary designation or the laws of
descent  and  distribution, then such act shall be treated as an election by the
Participant to withdraw from the Plan under Section 5(a).

10. NO RIGHTS AS AN EMPLOYEE.

     Nothing  in  the  Plan  shall  be construed to give any person the right to
remain  in  the  employ  of  a Participating Company. Each Participating Company
reserves  the  right to terminate the employment of any person at any time, with
or without cause.

11. NO RIGHTS AS A STOCKHOLDER.

     A  Participant  shall  have  no rights as a stockholder with respect to any
shares  that he or she has purchased, or may have a right to purchase, under the
Plan until the date of issuance of a stock certificate for such shares.

12. STOCK OFFERED UNDER THE PLAN.

     (a)  Authorized  Shares. The  aggregate number of shares of Stock available
for  purchase under the Plan shall be 300,000, subject to adjustment pursuant to
this Section 12.

     (b)  Anti-Dilution  Adjustments. The  aggregate  number  of shares of Stock
offered  under  the  Plan, the 10,000 share limitation described in Section 7(c)
and  the  price  of shares that any Participant has elected to purchase shall be
adjusted  proportionately  by  the Committee for any increase or decrease in the
number   of  outstanding  shares  of  Stock  resulting  from  a  subdivision  or
consolidation  of shares, the payment of a stock dividend, any other increase or
decrease  in such shares effected without receipt or payment of consideration by
the  Company  or the distribution of the shares of a Subsidiary to the Company's
stockholders.

     (c)  Reorganizations. In  the  event of a dissolution or liquidation of the
Company,  or  a  merger  or  consolidation to which the Company is a constituent
corporation,  the  Plan shall terminate unless the plan of merger, consolidation
or  reorganization  provides  otherwise, and all amounts that have been withheld
but  not  yet  applied  to  purchase  Stock hereunder shall be refunded, without
interest.  The  Plan  shall  in no event be construed to restrict in any way the
Company's  right  to undertake a dissolution, liquidation, merger, consolidation
or other reorganization.

13. AMENDMENT OR DISCONTINUANCE.

     The  Board of Directors shall have the right to amend, suspend or terminate
the  Plan  at any time and without notice. Except as provided in Section 12, any
increase  in the aggregate number of shares of Stock to be issued under the Plan
shall be subject to approval by a vote of the stockholders of the

                                      A-4

<PAGE>

Company.  In  addition,  any  other  amendment  of  the Plan shall be subject to
approval  by a vote of the stockholders of the Company to the extent required by
an applicable law or regulation.

14. DEFINITIONS.

     (a)   "Accumulation   Period"   means   a  six-month  period  during  which
contributions  may  be  made  toward  the  purchase  of Stock under the Plan, as
determined pursuant to Section 3(b).

     (b)  "Board  of  Directors" means the Board of Directors of the Company, as
constituted from time to time.

     (c)  "Committee" means a committee of the Board of Directors, consisting of
one or more directors appointed by the Board of Directors.

     (d)   "Company"   means  Neurobiological  Technologies,  Inc.,  a  Delaware
corporation.

     (e)  "Compensation"  means  the  total  compensation  paid  in  cash  to  a
Participant  by  a  Participating  Company,  including salaries, wages, bonuses,
incentive  compensation,  commissions  and overtime pay, but excluding moving or
relocation  allowances,  car  allowances, imputed income attributable to cars or
life  insurance, taxable fringe benefits and similar items, all as determined by
the Committee.

     (f) "Eligible Employee" means any employee of a Participating Company:

         (i)  Whose  customary  employment  is for more  than  five  months  per
     calendar year and for more than 20 hours per week; and

         (ii) Who has been an employee of a  Participating  Company for not less
     than three consecutive months.

     (g)  "Fair  Market  Value" shall mean the market price of Stock, determined
by the Committee as follows:

         (i) If Stock was traded  over-the-counter  on the date in question  but
     was not traded on the Nasdaq  Stock Market or the Nasdaq  National  Market,
     then the Fair  Market  Value  shall be equal to the mean  between  the last
     reported  representative  bid and asked prices  quoted for such date by the
     principal automated  inter-dealer quotation system on which Stock is quoted
     or, if the Stock is not  quoted on any such  system,  by the "Pink  Sheets"
     published by the National Quotation Bureau, Inc.;

         (ii) If Stock was traded  over-the-counter  on the date in question and
     was traded on the Nasdaq Stock Market or the Nasdaq National  Market,  then
     the Fair Market Value shall be equal to the  last-transaction  price quoted
     for such date by the Nasdaq Stock Market or the Nasdaq National Market;

         (iii)  If the  Stock  was  traded  on a stock  exchange  on the date in
     question,  then the Fair Market  Value shall be equal to the closing  price
     reported by the applicable composite transactions report for such date; and

         (iv) If none of the foregoing  provisions is applicable,  then the Fair
     Market  Value shall be  determined  by the  Committee in good faith on such
     basis as it deems appropriate.

     Whenever possible,  the determination of Fair Market Value by the Committee
     shall be based on the prices  reported in the  Western  Edition of The Wall
     Street Journal.  Such determination  shall be conclusive and binding on all
     persons.

                                       A-5

<PAGE>

     (h)  "Offering  Period"  means  a 24-month period with respect to which the
right  to  purchase  Stock may be granted under the Plan, as determined pursuant
to Section 3(a).

     (i)  "Participant"  means an Eligible Employee who elects to participate in
the Plan, as provided in Section 3(c).

     (j)  "Participating  Company"  means the Company and each present or future
Subsidiary, except Subsidiaries excluded by the Committee.

     (k)  "Plan"  means  this  Neurobiological Technologies, Inc. Employee Stock
Purchase Plan, as amended from time to time.

     (l)  "Plan  Account"  means  the  account  established for each Participant
pursuant to Section 6(a).

     (m)  "Purchase  Price"  means  the price at which Participants may purchase
Stock under the Plan, as determined pursuant to Section 7(b).

     (n) "Stock" means the Common Stock of the Company.

     (o)  "Subsidiary"  means  a  corporation, 50% or more of the total combined
voting  power  of  all  classes  of stock of which is owned by the Company or by
another Subsidiary.

15. EXECUTION.

     To  record  the  amendment  and  restatement  of  the  Plan by the Board of
Directors,  the  Company  has  caused  its  duly authorized officer to affix the
corporate name and seal hereto.

                                     NEUROBIOLOGICAL TECHNOLOGIES, INC.

                                     By /s/ Paul E. Freiman
                                        -------------------
                                     President and Chief Executive Officer

                                      A-6

<PAGE>

                                  APPENDIX B

                            AUDIT COMMITTEE CHARTER

Purposes:

The purposes of the audit committee are to:

Monitor the integrity of the financial statements of the company.

Oversee the independence of the company's independent auditor.

Recommend  to  the  board of directors the selection of the independent auditor,
evaluate   the   independent  auditor  and,  where  appropriate,  recommend  the
replacement   of   the   independent  auditor;  it  being  understood  that  the
independent  auditor is ultimately accountable to the board of directors and the
audit  committee,  and  that the board of directors and the audit committee have
the  ultimate  authority  and  responsibility  to  select,  evaluate  and, where
appropriate,  replace  the  independent  auditor  (or to propose the independent
auditor for stockholder approval).

Composition:

     The  audit  committee  shall  be  composed  of  three or more directors, as
determined  by  the  board  of  directors,  each  of  whom  shall be to meet the
independence  and  financial literacy requirements of Nasdaq and at least one of
whom  shall  have past employment experience in finance or accounting, requisite
professional  certification in accounting, or any other comparable experience or
background   which   results   in  the  individual's  financial  sophistication,
including  being  or  having  been  a  chief  executive officer, chief financial
officer or other senior officer with financial oversight responsibilities.

     Unless  a  chair  is  designated  by  the board of directors, the committee
members may appoint their own chair by majority vote.

Responsibilities:

     Recommend  to  the  board  of  directors  the  selection of the independent
auditor,  which  shall  ultimately be accountable to the audit committee and the
board of directors.

     Evaluate  the  written  disclosures  and  the  letter  that the independent
auditor  submits  to the audit committee regarding the auditor's independence in
accordance  with  Independence  Standards  Board  Standard  No.  1, discuss such
reports  with  the  auditor  and,  if  so  determined  by the audit committee in
response   to   such  reports,  recommend  that  the  board  of  directors  take
appropriate action to oversee the independence of the independent auditor.

     Discuss  with  the independent auditor the matters required to be discussed
by SAS 61, as it may be modified or supplemented.

     Meet  with management and the independent auditor to review and discuss the
annual  financial  statements  and the report of the independent auditor thereon
and,  to  the  extent  the  independent  auditor  or  management brings any such
matters  to  the attention of the audit committee, to discuss significant issues
encountered  in  the  course  of  the  audit work, including restrictions on the
scope  of activities, access to required information or the adequacy of internal
controls.

     Review  the  management  letter  delivered  by  the  independent auditor in
connection with the audit.

     Following  such  reviews  and  discussions,  if  so determined by the audit
committee,  recommend  to  the  board  of  directors  that  the annual financial
statements be included in the company's annual report.

                                       B-1

<PAGE>

     Meet  quarterly  with  management and the independent auditor to review and
discuss  the  quarterly  financial statements; provided that this responsibility
may be delegated to the chairman of the audit committee.

     Meet   at  least  once  each  year  in  separate  executive  sessions  with
management  and the independent auditor to discuss matters that the committee or
either  of  these  groups  believes  could  significantly  affect  the financial
statements and should be discussed privately.

     Have   such   meetings   with  management  as  the  audit  committee  deems
appropriate  to discuss significant financial risk exposures facing the company,
and steps management has taken to monitor and control such exposures.

     Review  significant  changes  to  the  company's  accounting principles and
practices proposed by the independent auditor or management.

     Evaluate  the  performance of the independent auditor and, if so determined
by  the  audit committee, recommend to the board of directors replacement of the
independent auditor.

     At  the  request  of company counsel, review with company counsel legal and
regulatory  matters  that  may  have  a  significant  impact  on  the  company's
financial statements, compliance policies or programs.

     Conduct  or  authorize  such  inquiries into matters within the committee's
scope  of responsibility as the committee deems appropriate. The committee shall
be  empowered to retain independent counsel and other professionals to assist in
the conduct of any such inquiries.

     Provide  minutes of audit committee meetings to the board of directors, and
report  to  the  board  of directors on any significant matters arising from the
committee's work.

     At  least  annually,  review and reassess this charter and, if appropriate,
recommend proposed changes to the board of directors.

     Prepare  the  report  required  by the rules of the Securities and Exchange
Commission to be included in the company's annual proxy statement.

     It  is  not  the  responsibility  of the audit committee to plan or conduct
audits,  or to determine whether the company's financial statements are complete
and  accurate or in accordance with generally accepted accounting principles. It
is  not  the  responsibility  of  the  audit  committee to conduct inquiries, to
resolve  disagreements,  if any, between management and the independent auditor,
or  to  assure  compliance with laws, regulations or company compliance policies
or programs.

                                       B-2

<PAGE>



PROXY                   NEUROBIOLOGICAL TECHNOLOGIES, INC.                 PROXY

                                    P R O X Y

           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     The  undersigned  hereby  appoints  Paul E. Freiman and Stephen C. Ferruolo
proxies,  and hereby authorizes each of them to represent and vote as designated
on  the  other  side,  all  the shares of stock of Neurobiological Technologies,
Inc.  standing  in  the  name  of  the  undersigned  with  all  powers which the
undersigned  would  possess  if present at the Annual Meeting of Stockholders of
the company to be held November 21, 2000 or any adjournment thereof.

       (Continued, and to be marked, dated and signed, on the other side)

                            - FOLD AND DETACH HERE -

<PAGE>

                                                            Please mark
                                                            your votes       [X]
                                                            as indicated in
                                                            this example

ITEM 1--ELECTION OF
        DIRECTORS

                               WITHHOLD
                      FOR       FOR ALL
        Nominees:     [ ]         [ ]

        Paul E. Freiman,
        Theodore L. Eliot, Jr.,
        Abraham E. Cohen,
        Abraham D. Sofaer,
        Enoch Callaway, M.D.,
        John B. Stuppin

WITHHELD FOR: (Write that nominee's name in
the space provided below.)

-------------------------------------------

<TABLE>
                                                                FOR  AGAINST  ABSTAIN
<S>                                                             <C>    <C>      <C>
ITEM 2--APPROVAL OF AMENDMENT TO EMPLOYEE STOCK PURCHASE PLAN   [ ]    [ ]      [ ]

ITEM 3--APPROVAL OF AMENDMENT TO RESTATED CERTIFICATE OF        [ ]    [ ]      [ ]
        INCORPORATION

ITEM 4--RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS     [ ]    [ ]      [ ]
</TABLE>

Signature(s)                                              Dated           , 2000
            ---------------------------------------------       ----------

Please  date  and  sign exactly as name appears hereon. Joint owners should each
sign.  When  signing  as attorney, executor, administrator, trustee or guardian,
please give full title as such.

                            - FOLD AND DETACH HERE -



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