NEUROBIOLOGICAL TECHNOLOGIES INC /CA/
PRE 14A, 2000-10-04
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 14A
                                 (RULE 14A-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

      PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES EXCHANGE
                          ACT OF 1934 (AMENDMENT NO.)

     Filed by the  Registrant /X/
     Filed by a Party other than the Registrant / /
     Check the appropriate box:

     /X/ Preliminary Proxy Statement       / / Confidential, for Use of the
                                               Commission Only (as permitted
                                               by Rule 14a-6(e)(2))

     / / Definitive Proxy Statement
     / / Definitive Additional Materials
     / / Soliciting Material Under Rule 14a-12

                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
--------------------------------------------------------------------------------
                (Name of Registrant as Specified in its Charter)

--------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

     /X/ No fee required.

     / / Fee computed on table below per Exchange  Act Rules  14a-6(i)(1)  and
         0-11.

     (1) Title of each class of securities to which transaction applies:

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     (2) Aggregate number of securities to which transaction applies:

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     (3) Per unit  price  or other  underlying  value  of  transaction  computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee
is calculated and state how it was determined):

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     (4) Proposed maximum aggregate value of transaction:

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     (5) Total fee paid:

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     / / Fee paid previously with preliminary materials:

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     / / Check box if any part of the fee is offset as provided by Exchange  Act
Rule  0-11(a)(2)  and identify the filing for which the  offsetting fee was paid
previously.  Identify the previous filing by registration  statement  number, or
the form or schedule and the date of its filing.

     (1) Amount Previously Paid:



<PAGE>


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     (2) Form, Schedule or Registration Statement No.:

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     (3) Filing Party:

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     (4) Date Filed:

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<PAGE>


                                     [LOGO]



                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                           3260 Blume Drive, Suite 500
                           Richmond, California 94806
                                 (510) 262-1730


                                October 13, 2000




Dear Stockholder:

         You are cordially  invited to attend the Annual Meeting of Stockholders
of Neurobiological Technologies, Inc. The Annual Meeting will be held at the St.
Francis Yacht Club, On The Marina, in San Francisco,  California on November 21,
2000 at 10 a.m..

         The formal notice of the Annual  Meeting and the Proxy  Statement  have
been made a part of this invitation.

         At your earliest convenience and after you have read the enclosed Proxy
Statement,  please  mark,  date and sign the  enclosed  proxy and  return in the
enclosed prepaid envelope  addressed to ChaseMellon  Shareholder  Services,  our
transfer  agent,  to ensure that your shares  will be  represented.  YOUR SHARES
CANNOT BE VOTED UNLESS YOU SIGN,  DATE AND RETURN THE  ENCLOSED  PROXY OR ATTEND
THE ANNUAL MEETING IN PERSON.

         A copy of the Company's Annual Report on Form 10-KSB is also enclosed.

         The Board of Directors and Management look forward to seeing you at the
Annual Meeting.

                                 Sincerely yours,



                                 Paul E. Freiman
                                 President and Chief Executive Officer



<PAGE>



                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                                 ---------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                      TO BE HELD TUESDAY, NOVEMBER 21, 2000
                                 ---------------

THE STOCKHOLDERS OF NEUROBIOLOGICAL TECHNOLOGIES, INC.:

         The Annual Meeting of  Stockholders  of  Neurobiological  Technologies,
Inc. ("NTI" or the "Company") will be held at the St. Francis Yacht Club, On The
Marina, San Francisco,  California, on November 21, 2000 at 10 a.m., local time,
for the following purposes:

     1.  To elect six directors to hold office until the next annual  meeting of
         stockholders and until their successors are elected.

     2.  To approve an amendment to the Company's  Amended and Restated Employee
         Stock Purchase Plan to increase the number of shares issuable under the
         plan by 150,000 to a total of 300,000 shares.

     3.  To  approve an  amendment  to the  Company's  Restated  Certificate  of
         Incorporation  to  increase  the  number  of  authorized  shares of the
         Company's common stock by 10,000,000 to a total of 35,000,000 shares.

     4.  To  ratify  the  appointment  of  Ernst  & Young  LLP as the  Company's
         independent auditors.

     5.  To transact such other business as properly may come before the meeting
         or any adjournments or postponements of the meeting.

         The foregoing  items of business are more fully  described in the Proxy
Statement accompanying this Notice.

         Only stockholders of record at the close of business on October 2, 2000
are  entitled  to  notice  of,  and to  vote  at,  the  Annual  Meeting  and any
adjournments or  postponements  of the meeting.  A complete list of stockholders
entitled to notice of and to vote at the Annual Meeting will be available at the
Company's offices,  3260 Blume Drive, Suite 500, Richmond,  California,  for ten
days before the meeting.

         All stockholders are cordially invited to attend the meeting in person.
However,  to assure your  representation at the meeting,  you are urged to mark,
sign,  date and return the enclosed proxy as promptly as possible in the postage
prepaid  envelope  enclosed for that  purpose.  Any  stockholder  attending  the
meeting may vote in person even if he or she returned a proxy.

                                By Order of the Board of Directors,



                                Paul E. Freiman
                                President and Chief Executive Officer


Richmond, California
October 13, 2000



--------------------------------------------------------------------------------
                                    IMPORTANT

WHETHER  OR NOT YOU EXPECT TO ATTEND THE  MEETING  IN  PERSON,  PLEASE  SIGN AND
RETURN  THE  ENCLOSED  PROXY  AS  SOON AS  POSSIBLE  IN THE  ENCLOSED  POST-PAID
ENVELOPE. THANK YOU FOR ACTING PROMPTLY.
--------------------------------------------------------------------------------


<PAGE>




                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                           3260 BLUME DRIVE, SUITE 500
                               RICHMOND, CA 94806
                                 (510) 262-1730
                                  ------------

                                 PROXY STATEMENT

                                  ------------

         The  enclosed  proxy is  solicited  on behalf of the Board of Directors
(the  "Board") of  Neurobiological  Technologies,  Inc., a Delaware  corporation
("NTI" or the  "Company").  The proxy is solicited for use at the Annual Meeting
of Stockholders (the "Annual Meeting") to be held at the St. Francis Yacht Club,
On The Marina,  in San Francisco,  California,  on November 21, 2000 at 10 a.m.,
local  time,  and at any and all  adjournments  or  postponements  thereof.  The
approximate date on which this proxy statement and the  accompanying  notice and
proxy are being mailed to stockholders is October 13, 2000.

                 INFORMATION CONCERNING SOLICITATION AND VOTING

         Only stockholders of record at the close of business on October 2, 2000
are  entitled  to  notice  of,  and to  vote  at,  the  Annual  Meeting  and any
adjournments or  postponements  thereof.  At the close of business on October 2,
2000, the Company had outstanding  16,311,278  shares of Common Stock, par value
$.001 per share  ("Common  Stock")  and  2,182,000  shares of Series A Preferred
Stock,  par value  $.001 per share (the  "Preferred  Stock").  Holders of Common
Stock are entitled to one vote for each share of Common  Stock held.  Holders of
Preferred  Stock are entitled  one vote for each share of Preferred  Stock held.
The holders of Common Stock and  Preferred  Stock will vote together as a single
class on all matters described in this proxy statement. In order to constitute a
quorum for the  conduct of  business  at the Annual  Meeting,  a majority of the
outstanding shares entitled to vote at the Annual Meeting must be represented at
the Annual Meeting.

         All shares  represented  by each  properly  executed,  unrevoked  proxy
received in time for the Annual Meeting will be voted in the manner specified in
the  proxy.  If the  manner of  voting is not  specified  in an  executed  proxy
received  by the  Company,  the  proxy  will be voted  for the  election  of the
directors  listed in the proxy for election to the Board and for approval of the
other proposals described in this proxy statement.

         Directors are elected by a plurality  vote.  The proposed  amendment to
the Company's  Restated  Certificate of  Incorporation to increase the number of
authorized  shares of Common  Stock  requires  the approval of a majority of the
shares  entitled  to vote on the  amendment.  All other  matters  submitted  for
stockholder  approval at the Annual  Meeting will be decided by the  affirmative
vote of a majority of shares  present in person or  represented  by proxy at the
Annual Meeting and entitled to vote on each such matter. Votes will be tabulated
as  follows:  (1)  abstentions  are  treated as votes  against a  proposal;  (2)
executed  proxies are voted as indicated on the proxy; (3) executed proxies with
no preferences are treated as votes for a proposal; and (4) broker non-votes are
treated as votes  against  the  proposal to increase  the  authorized  number of
shares of Common Stock, but have no effect on the vote on the other proposals. A
broker  non-vote  occurs  when a  broker  lacks  the  authority  to vote on some
proposals.   Abstentions  and  broker   non-votes  are  counted  as  present  or
represented at the Annual  Meeting for purposes of determining  whether a quorum
is present.

         Any  stockholder  giving a proxy in the form  accompanying  this  proxy
statement has the power to revoke the proxy prior to its  exercise.  A proxy can
be revoked by delivering an instrument of revocation prior to the Annual Meeting
to the  Company,  by  presenting  at the Annual  Meeting a duly  executed  proxy
bearing a later date or time than the date or time of the proxy  being  revoked,
or at the Annual  Meeting if the  stockholder  is present  and elects to vote in
person. Mere attendance at the Annual Meeting will not serve to revoke a proxy.

         The expense of printing and mailing  proxy  materials  will be borne by
the Company.  In addition to the  solicitation of proxies by mail,  solicitation
may be made by certain directors, officers and other employees of the Company by
personal interview,  telephone or facsimile.  No additional compensation will be
paid to such persons for such solicitation. The Company will reimburse brokerage
firms and  others  for their  reasonable  expenses  in  forwarding  solicitation
materials to beneficial owners of the Company's stock.



<PAGE>


                                   PROPOSAL 1

                              ELECTION OF DIRECTORS


Nominees

         The Board of  Directors  proposes  the  election of the  following  six
directors of the Company.  Directors  are elected to serve until the next annual
meeting of  stockholders  and until their  successors are elected and qualified.
The nominees securing the highest number of votes, up to the number of directors
to be  elected,  will be elected  as  directors.  It is  intended  that  proxies
received  will be voted FOR the  election of the  nominees  named  below  unless
marked to the  contrary.  In the event any such person is unable or unwilling to
serve as a director,  proxies may be voted for substitute nominees designated by
the present  Board.  The Board has no reason to believe  that any of the persons
named below will be unable or unwilling to serve as a director if elected.

<TABLE>
         All six nominees are currently serving as directors of the Company. The
following  table  indicates  the name and age of each  nominee as of the date of
this proxy  statement,  all positions with the Company held by the nominee,  and
the year during which the nominee first was elected or appointed a director.
<CAPTION>

                                                                            Director Continuously
           Name               Age     Position with NTI                             Since
           ----               ---     -----------------                             -----
<S>                            <C>    <C>                                            <C>
Paul E. Freiman                66     President, Chief Executive Officer
                                        and Director                                 1997
Abraham E. Cohen               64     Chairman of the Board of Directors             1993
Enoch Callaway, M.D.           76     Director                                       1987
Theodore L. Eliot, Jr.         72     Director                                       1992
Abraham D. Sofaer              62     Director                                       1997
John B. Stuppin                67     Director                                       1988
</TABLE>

         Paul E. Freiman  joined the Company as a director in April 1997 and was
elected  President  and Chief  Executive  Officer in May 1997.  He is the former
chairman  and  chief  executive  officer  of  Syntex  Corporation.  Mr.  Freiman
currently serves as chairman of the boards of Digital GeneTechnologies,  Inc., a
private genomics  company,  and SciGen Pte. Ltd. Mr. Freiman currently serves on
the  boards of  Penwest  Pharmaceutical  Co.,  Calypte  Biomedical  Corporation,
Omware, Inc., PHYTOS, Inc. and Otsuka America Pharmaceuticals,  Inc. He has been
chairman of the Pharmaceutical Manufacturers Association of America (PhARMA) and
has also  chaired a number of key  PhARMA  committees.  Mr.  Freiman  is also an
advisor to Burrill & Co., a San Francisco  merchant  bank.  Mr.  Freiman holds a
B.S. degree from Fordham  University and an honorary doctorate from the Arnold &
Marie Schwartz College of Pharmacy.

         Abraham E. Cohen has been a director  of the  Company  since March 1993
and has been Chairman of the Board of Directors  since August 1993. From 1982 to
1992,  Mr. Cohen served as senior vice president of Merck & Co. and from 1977 to
1988 as President of the Merck Sharp & Dohme International  Division.  Since his
retirement  from Merck and MSDI in January 1992, Mr. Cohen has been active as an
international business consultant. He was a director of Agouron Pharmaceuticals,
Inc. until its merger with Warner-Lambert Company. He is currently a director of
seven  other  public   companies:   Akzo  Nobel  N.V.,   Axonyx,   Inc.,  Chugai
Pharmaceutical  Co.,  Pharmaceutical  Product  Development,  Inc.,  Smith Barney
Mutual  Funds,  Teva  Pharmaceutical  Industries,  Ltd.  and  Vasomedical,  Inc.
Additionally, he serves as a Trustee on The Population Council.

         Enoch  Callaway,  M.D. is a founder and former  employee of the Company
and has served as a director of the Company since  September  1987. Dr. Callaway
previously  served as Chairman  of the Board of  Directors  of the Company  from
September 1987 to November 1990, as Co-Chairman of the Board of the Company from
November 1990 until August 1993, as Vice President of the Company from September
1988 until August 1993 and as Secretary of the Company from September 1988 until
September  1991. Dr.  Callaway has been Emeritus  Professor of Psychiatry at the
University  of  California,  San Francisco  since 1986,  where he also served as
Director of Research at the Langley  Porter  Psychiatric  Institute from 1959 to
1986.  Dr.  Callaway was Staff  Psychiatrist,  SFVAMC from 1996 to 1997. He is a
member of the IRB for SAM Technologies, Inc. and Abratek, Inc. Dr. Callaway is a
director  of  Phytos,  Inc.  He  holds  A.B.  and  M.D.  degrees  from  Columbia
University.


                                       2

<PAGE>

         Theodore  L. Eliot,  Jr. has served as a director of the Company  since
August 1992.  Previously,  he served as a director of the Company from September
1988 until April 1992,  and as a Vice  President of the Company  from  September
1988 until September  1991. Mr. Eliot retired from the United States  Department
of  State in 1978,  after a  30-year  career  in which he held  senior  posts in
Washington and was Ambassador to Afghanistan. He was Dean of the Fletcher School
of Law and Diplomacy  from 1978 to 1985 and a director of Raytheon Co. from 1983
to  1998.  He is  currently  a  director  of  Fiberstars,  Inc.  and of  several
non-profit  organizations.  Mr. Eliot holds B.A. and M.P.A. degrees from Harvard
University.

         Abraham D. Sofaer has served as a director  of the Company  since April
1997.  Mr. Sofaer is the first George P. Shultz  Distinguished  Scholar & Senior
Fellow at the Hoover Institution, Stanford University, appointed in 1994. He has
also been a Professor  of Law (by  courtesy)  at Stanford Law School since 1997.
From 1990 to 1994, Mr. Sofaer was a partner at the legal firm of Hughes, Hubbard
and Reed in Washington,  D.C.,  where he represented  several major U.S.  public
companies.  From 1985 to 1990,  he served as the  Legal  Adviser  to the  United
States  Department  of  State,  where he was  principal  negotiator  on  several
international  disputes.  From 1979 to 1985, he served as a federal judge in the
Southern  District  of  New  York.  Mr.  Sofaer  is  registered  as a  qualified
arbitrator  with the  American  Arbitration  Association  and is a member of the
National Panel of the Center for Public  Resolution of Disputes (CPR), a leading
organization in the area of resolution of disputes  outside  litigation.  He has
mediated  major  commercial  cases.  Additionally,   he  acts  regularly  as  an
arbitrator in merger-acquisition disputes,  commercial cases involving valuation
of  technology,  and  securities  class  action  suits.  Mr.  Sofaer  is on  the
International Advisory Board of Chugai  Biopharmaceuticals,  Inc., a director of
Koret Israel Economic  Development  Fund and a trustee of the National Museum of
Jazz. Mr. Sofaer holds a B.A. degree from Yeshiva College and a L.L.B.  from New
York University.

         John B. Stuppin is a founder and employee of the Company and has served
as a director of the Company since  September  1988.  From  September 1987 until
October 1990, Mr. Stuppin served as President of the Company, from November 1990
to August 1993 as Co-Chairman of the Board of Directors, from October 1990 until
September 1991 as Executive Vice President,  and from April 1991 until July 1994
as Treasurer.  He also served as acting Chief  Financial  Officer of the Company
from the Company's inception through December 1993. Mr. Stuppin is an investment
banker and a venture capitalist. He has over 25 years experience in the start up
and  management of companies  active in emerging  technologies  and has been the
president of a manufacturing company. He is chairman of the board of Fiberstars,
Inc. Mr. Stuppin holds an A.B. degree from Columbia College.

         The Board of Directors recommends a vote "FOR" election of the nominees
set forth above.

Board Meetings and Committees

         The Board of Directors held nine meetings  during the fiscal year ended
June 30, 2000.  All directors  attended at least 75% of the aggregate  number of
meetings of the Board of Directors  and of  committees  on which such  directors
serve.

         The Board of Directors has appointed a Compensation Committee, an Audit
Committee and a Nominating Committee.

         The members of the  Compensation  Committee are Theodore L. Eliot,  Jr.
and Abraham D. Sofaer.  The  Compensation  Committee  held four meetings  during
fiscal  2000.  The  Compensation  Committee's  functions  are to  assist  in the
implementation  of, and provide  recommendations  with  respect to,  general and
specific  compensation  policies and  practices of the  Company,  including  the
administration  of and granting of options under the  Company's  1993 Stock Plan
and Amended and Restated Employee Stock Purchase Plan.

         The members of the Audit Committee are Theodore L. Eliot,  Jr., Abraham
E. Cohen, and Abraham D. Sofaer. Each member is "independent" under the National
Association of Securities Dealers' listing standards. The Board of Directors has
adopted a charter  for the Audit  Committee  in the form  attached to this proxy
statement  as Appendix B. The Audit  Committee  held one meeting  during  fiscal
2000.  The Audit  Committee's  functions  are to review  the scope of the annual
audit, monitor the independent auditor's  relationship with the Company,  advise
and assist the Board of  Directors  in  evaluating  the  auditor's  examination,
supervise the  Company's  financial and  accounting  organization  and financial
reporting and recommend for approval by the Board of Directors and  ratification
at the Annual Meeting a firm of certified public accountants whose duty it is to
audit the  financial  records

                                       3

<PAGE>





of the  Company  for the  fiscal  year for  which  it is  appointed.  The  Audit
Committee has reviewed and discussed the audited  financial  statements with the
Company's management team, discussed with the Company's independent auditors all
matters pursuant to SAS 61 (Codification of Statements on Auditing Standards, AU
ss. 380) and  received a report from the  Company's  independent  auditors  with
respect to the financial  statements and  disclosures.  The Audit  Committee has
also  received and reviewed the letter from the Company's  independent  auditors
required by  Independence  Standards Board Standard No. 1 and discussed with the
auditors their  independence  from the Company.  Based upon all such reviews and
discussions,  recommended to the Board of Directors  that the audited  financial
statements  be included in the  Company's  Annual  Report on Form 10-KSB for the
fiscal  year ended June 30,  2000 for filing with the  Securities  and  Exchange
Commission.

                                                Abraham E. Cohen, Chairman
                                                Thomas L. Eliot, Jr.
                                                Abraham D. Sofaer

         The members of the Nominating Committee are Dr. Enoch Callaway and John
B. Stuppin.  The Nominating  Committee held no meetings  during fiscal 2000. The
Nominating  Committee is responsible for matters  relating to the composition of
the Board of Directors,  including  recruitment,  nomination and succession.  No
nominations  were  received  from  stockholders,  and no  procedures  have  been
established for any such nominations.

Directors' Compensation

         Dr.  Callaway  was paid  $15,000  during  fiscal  2000  for  consulting
services rendered to the Company pursuant to a consulting agreement. Mr. Stuppin
was paid $13,008 during fiscal 2000 as an employee of the Company.  Mr. Cohen is
reimbursed for his expenses for each meeting attended.

         Non-employee  directors are currently  eligible to  participate  in the
Company's 1993 Stock Plan. Subject to the 1993 Stock Plan, each new non-employee
director  of the Company  will  receive an option to  purchase  5,000  shares of
Common  Stock on the date of his or her  election  to the Board with an exercise
price equal to the fair market  value of the Common  Stock on the date of grant.
In addition,  each non-employee  director  continuing to serve on the Board will
also receive an automatic  annual grant of an option to purchase 1,000 shares of
Common Stock after each annual meeting of the Company's stockholders.

         In December 1999,  Mr. Freiman was granted a nonqualified  stock option
to purchase  150,000  shares of Common  Stock at an exercise  price of $0.80 per
share. The option vests in full on December 2004 or earlier, in whole or inpart,
in the event of a change of control of the Company.

         In May, 2000,  Dr.  Callaway and Messrs.  Cohen,  Eliot and Sofaer were
each granted an option to purchase 20,000 shares of Common Stock and Mr. Stuppin
was  granted an option to  purchase  50,000  shares of Common  Stock,  all at an
exercise  price of $6.188  per  share.  The  options  vest  over  four  years in
accordance  with  the  Company's   standard  vesting  policy  and  become  fully
exercisable  in the event of a change of control  as  defined  in the  Company's
Amended and Restated 1993 Stock Plan.


                                       4

<PAGE>
<TABLE>
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         The  following  table sets forth  information  regarding  the Company's
outstanding  shares of each class of equity securities  beneficially owned as of
October  2,  2000  by:  (1) each  person  who is  known  to the  Company  to own
beneficially  more than five  percent  of each class of the  outstanding  equity
securities;  (2) each of the Company's directors;  (3) the officers named in the
Summary  Compensation  Table below; and (4) all directors and executive officers
as  a  group.  The  information  relating  to  share  ownership  is  based  upon
information  furnished  to the  Company.  The  number of shares of Common  Stock
beneficially  owned by an individual as reported in the second column below,  as
well as the number of shares of Common  Stock  deemed  outstanding  in computing
such individual's  percentage  ownership as reported in the fourth column below,
includes  shares of Common Stock  issuable upon  conversion of shares subject to
warrants or options  exercisable within 60 days after October 2, 2000 as if such
shares were  outstanding on October 2, 2000, but does not include shares subject
to any other  warrants or  options.  The Company  believes  that the  beneficial
owners of each class of equity securities, based on information supplied by such
owners, have sole investment and voting power with respect to the shares of each
class of equity securities shown as being  beneficially owned by them, except as
otherwise set forth in the footnotes to the table.
<CAPTION>
                                                          Number Subject
                                                           to Options and                   Number of     Percentage
                                          Number of           Warrants       Percentage of   Shares of     of Series A
                                          Shares of          Exercisable       Common        Series A      Preferred
            Name and Address             Common Stock      Within 60 days       Stock     Preferred Stock     Stock
 -------------------------------------------------------------------------------------------------------------------
<S>                                       <C>                <C>                <C>           <C>             <C>
 Lindsay A. Rosenwald, M.D. (1)........   1,759,500          500,000            10.5%              --          --
      787 Seventh Avenue, 48th Floor
      New York, NY 10019

Arthur Rock (2).......................    1,185,997          436,071             7.1          500,000         22.9%
      One Maritime Plaza, #1220
      San Francisco, CA 94111

 New York Life Insurance Company (3)...     553,750               --             3.4          400,000         18.3
      51 Madison Avenue, Room 206
      New York, NY 10010

 Clipper Bay ...........................    900,000               --             5.5               --          --
      55 Water Street, 3rd Floor
      New York, NY 10041

 Paul E. Freiman (4)...................     380,075          324,375             2.3               --          --

 Enoch Callaway, M.D. (5)..............     136,990           37,742             *              4,000          *

 Abraham E. Cohen .....................     576,391          306,554             3.5          100,000          4.6

 Theodore L. Eliot, Jr. (6)............      86,660           59,116             *                 --          --

 Abraham D.Sofaer .....................     569,431          291,504             3.4          100,000          4.6

 John B. Stuppin (7)...................     675,431            6,250             4.1          100,000          4.6

 Lisa U. Carr, M.D., Ph.D .............      43,658           32,021             *                 --          --

 All directors and executive officers
 (as a group 7 persons)(8).............   2,468,546        1,057,562            14.2          304,000         13.9
<FN>
---------------------------
*Less than 1%

(1) According to Schedule 13G dated  February 8, 2000 and Form 4 dated June 2000
    filed by Lindsay A. Rosenwald, M.D.

(2) According  to Schedule  13D/A filed by Arthur Rock on November  19, 1999 and
    the Company's records.

(3) According  to  Schedule  13G filed by New York  Life  Insurance  Company  on
    February 12, 1997.

(4) The number of shares of common stock shown  includes  55,700  shares held in
    the estate of Paul E. Freiman and Anna Mazzuchi Freiman.

(5) The number of shares of common stock shown  includes  99,248  shares held by
    Enoch  Callaway and Dorothy C. Callaway,  Trustees or Successor  Trustees of
    the Callaway 1989 Trust,  executed May 20, 1989. Dr.  Callaway may be deemed
    to have a beneficial interest in the shares held by the Callaway Trust.

(6) The number of shares of common stock shown  includes  27,544  shares held by
    Theodore L. Eliot,  Jr. and  Patricia P. Eliot,  Trustees,  the Eliot Trust,
    February 27, 1987. Mr. Eliot may be deemed to have a beneficial  interest in
    the shares held by the Eliot Trust.

                                       5

<PAGE>


(7) The number of shares of common stock shown  includes  667,681 shares held by
    John B. Stuppin and Jane K.  Stuppin,  Trustees UTD dated March 11, 1991 and
    500  shares  held by Mrs.  Stuppin.  Mr.  Stuppin  may be  deemed  to have a
    beneficial  interest  in the  shares  held by the  Stuppin  Trust  and  Mrs.
    Stuppin.

(8) The number of shares of common stock shown includes shares included pursuant
    to notes 4-7.
</FN>
</TABLE>


<TABLE>
Executive Compensation

         The following table sets forth information  regarding  compensation for
the fiscal years ended June 30, 1998,  1999 and 2000  received by the  Company's
Chief  Executive  Officer during fiscal 2000 and the Company's other most highly
compensated  executive  officer  whose total annual  salary and bonus for fiscal
year 2000 exceeded $100,000 (the "Named Officers").
<CAPTION>

                                    Summary Compensation Table

                                                    Annual Compensation
                                                --------------------------
                                                                                  Long-Term
                                                                             Compensation Awards
        Name and Principal Position as of                                    -------------------
                  June 30, 2000                 Year  Salary ($)  Bonus($)       Options(#)
                  -------------                 ----  ----------  --------       ----------

<S>                                             <C>     <C>            <C>          <C>
Paul E. Freiman                                 2000    155,055        0            225,000
   President and Chief Executive Officer        1999    152,527        0            200,000
                                                1998     92,533        0            250,000
Lisa U. Carr, M.D., Ph.D.(1)                    2000    102,743        0             52,500
   Vice President, Medical Affairs              1999    104,360        0            100,000
                                                1998      8,333        0                  0


<FN>
---------------------------
(1)  Dr. Carr joined the Company on June 1, 1998.  Fiscal 1998  compensation  is
     for partial year.
</FN>
</TABLE>


                                       6

<PAGE>

<TABLE>
         The following table sets forth further information regarding the grants
of stock  options  during  the  fiscal  year  ended  June 30,  2000 to the Named
Officers.  Since inception,  the Company has not granted any stock  appreciation
rights.
<CAPTION>



                             Option Grants in Fiscal 2000


                                                         Individual Grant
                                  ---------------------------------------------------------------

                                                        Percent of
                                      Number of       Total Options
                                     Securities          Granted
                                     Underlying       to Employees in    Exercise or
                                      Options            Fiscal           Base Price    Expiration
                 Name             Granted (#)(1)       2000(%)(2)        ($/Share)(1)     Date
                 ----             --------------       ----------        ------------     ----

<S>                                   <C>                 <C>               <C>          <C>  <C>
Paul E. Freiman                       150,000(3)          38.8              0.80         12/3/09
                                       75,000(4)          19.4              6.188        5/17/10

Lisa U. Carr, M.D., Ph.D.              12,500(4)           3.2              0.891        9/28/09
                                       40,000(4)          10.3              6.188        5/17/10
<FN>
-------------------------
(1)  The options  were granted  under the  Company's  Amended and Restated  1993
     Stock Plan.  The exercise  price of all the options,  other than the option
     granted to Mr. Freiman to purchase 150,000 shares, was equal to 100% of the
     fair market value on the date of grant. The fair market value of the Common
     Stock on  December 3, 1999,  the date on which Mr.  Freiman was granted the
     option to purchase 150,000 shares, was $2.56.

(2)  Based on a total of  387,000  stock  options  granted to  employees  during
     fiscal year ended June 30, 2000.

(3)  These  options  become  exercisable  five  years  from the date of grant or
     earlier, in whole or in part, upon a change of control of the Company.

(4)  The options vest 12.5% six months after the date of grant and 2.08% monthly
     thereafter.
</FN>
</TABLE>


         Both of the Named  Officers  exercised  options during fiscal 2000. The
following  table  sets  forth  information  regarding  the  number  and value of
unexercised options held by the Named Officers at fiscal year-end.

<TABLE>
<CAPTION>
                    Aggregated Option Exercises and Fiscal Year-End Option Values in Last Fiscal Year

                                                                                                 Value of Unexercised
                             Number of                      Number of Unexercised Options        In-the-Money Options
                              Shares                         Held at Fiscal Year End(#)        at Fiscal Year End($)(1)
                            Acquired on       Value         ----------------------------    ----------------------------
          Name              Exercise (#)    Realized($)     Exercisable    Unexercisable    Exercisable    Unexercisable
          ----              ------------    -----------     -----------    -------------    -----------    -------------
<S>                         <C>            <C>             <C>             <C>             <C>             <C>
Paul E. Freiman             60,000         356,220         760,000         495,000         1,800,250       3,278,730

Lisa U. Carr, M.D., Ph.D.   38,375         229,051         114,125          99,031           118,242         554,648


<FN>
-------------------------
(1)  Based on the  amount,  if any,  by which  the last per  share  quote of the
     Common Stock on the OTC Bulletin Board on June 30, 2000 ($8.50) exceeds the
     exercise price.
</FN>
</TABLE>


                                       7


<PAGE>




Section 16(a) Beneficial Ownership Reporting Compliance

         Under the  Securities  Exchange Act of 1934, as amended,  the Company's
directors,  executive  officers  and any  persons  holding  more than 10% of the
Company's  Common Stock are required to report  their  initial  ownership of the
Company's  Common  Stock and any  subsequent  changes in that  ownership  to the
Securities  and Exchange  Commission.  Specific due dates for these reports have
been  established,  and the  Company  is  required  to  identify  in this  Proxy
Statement  those persons who failed to timely file these reports.  During fiscal
2000,  Mr.  Freiman  failed to file a timely  Form 5 with  respect to the option
granted  to him in  December  1999.  A Form 5  reporting  the grant was filed in
September 2000. The Company believes all other required reports have been timely
filed.  In making this  disclosure,  the  Company  has relied  solely on written
representations  of its  directors  and  executive  officers  and  copies of the
reports that have been filed with the Commission.

                                   PROPOSAL 2

                          APPROVAL OF AMENDMENT OF THE
                AMENDED AND RESTATED EMPLOYEE STOCK PURCHASE PLAN

         The  Neurobiological  Technologies,  Inc. Amended and Restated Employee
Stock  Purchase  Plan (the  "ESPP")  was  adopted by the Board of  Directors  on
December 15, 1993 and approved by the  stockholders  in January 1994. As of June
30, 2000, an aggregate of 150,000 shares were authorized for issuance and 33,133
shares remained available for future purchases under the ESPP.

Summary of Amendment

         On September 8, 2000,  the Board of Directors  approved an amendment to
the ESPP to increase the number of shares  reserved for purchase  under the ESPP
by up to 150,000 to up to  300,000,  subject to the  approval  of the  Company's
stockholders  at the annual meeting.  The ESPP, as amended,  is attached to this
proxy statement as Appendix A.

        Description of Amended and Restated Employee Stock Purchase Plan

         Under the ESPP,  an aggregate of 300,000  shares of Common Stock (which
number includes the 150,000-share increase that the stockholders are being asked
to approve) have been reserved for issuance. As of June 30, 2000, nine employees
were eligible to participate in the ESPP. Eligible employees  participate in the
ESPP by authorizing payroll deductions of any whole percentage, not less than 1%
nor more than 10%, of their total cash compensation. No employee is permitted to
purchase  Common Stock under the ESPP at a rate which exceeds  $25,000 of Common
Stock  valued at fair market  value  (determined  at the time the  participant's
rights are granted) per year. At the end of each six month  period,  the Company
will apply the amount  contributed  by the  participant  during  that  period to
purchase up to a maximum of 2,500 whole shares of Common Stock.

         All  employees  who  have  been  employed  by  the  Company  for  three
consecutive months and are customarily employed 20 or more hours a week and five
or more months each year are eligible to  participate  in the ESPP. Any eligible
employee may enroll in the ESPP by executing the  enrollment  form no later than
one week prior to the last working day prior to the commencement of the offering
period.  The offering period consists of the 24-month period  commencing on each
January 1 and July 1. Shares of Common  Stock are  purchased at 85% of the lower
of (i) the market price of Common Stock immediately  before the beginning of the
applicable offering period and (ii) the market price of such Common Stock at the
time of the purchase.

         The  ESPP  is  administered   by  the   Compensation   Committee.   The
Compensation  Committee  has the  right  to  interpret  the  ESPP,  adopt  rules
thereunder  and to make all other  decisions  relating to the  operation  of the
ESPP.  The Board of Directors  has the right to amend,  suspend or terminate the
ESPP at any time and without  notice.  All expenses  incurred in connection with
the implementation and administration of the ESPP are paid by the Company.

Required Approval


                                       8


<PAGE>

         Approval of this proposal  requires the affirmative  vote of a majority
of the shares  present in person or  represented  by proxy at the Annual Meeting
and entitled to vote on the proposal.

         The Board of  Directors  recommends  a vote "FOR" the  adoption  of the
amendment of the Company's Amended and Restated Employee Stock Purchase Plan.



                                   PROPOSAL 3

   APPROVAL OF AMENDMENT TO RESTATED CERTIFICATE OF INCORPORATION TO INCREASE
                             AUTHORIZED COMMON STOCK

         On September 8, 2000,  the Board of Directors  unanimously  approved an
amendment to the Company's Restated Certificate of Incorporation to increase the
number of shares of authorized Common Stock from 25,000,000 shares to 35,000,000
shares.  Of the 25,000,000  currently  authorized  shares of Common Stock, as of
October 2,  2000,  16,311,278  were  issued and  outstanding.  Of the  remaining
8,688,722  authorized  shares of  Common  Stock,  7,920,857  were  reserved  for
issuance in connection  with the Company's  stock option plan and stock purchase
plan and for issuance  upon the exercise of  outstanding  warrants and Preferred
Stock. If Proposal 2 amending the ESPP is approved by stockholders at the Annual
Meeting,  an additional  150,000  shares will be reserved for issuance under the
ESPP.

         Except for the increase in shares  authorized  for  issuance  under the
ESPP,  Company  does not have any current  plan,  understanding  or agreement to
issue additional  shares of Common Stock.  However,  the Board believes that the
proposed  increase in authorized  shares of Common Stock is desirable to enhance
the Company's  flexibility in connection with possible  future actions,  such as
stock splits, stock dividends,  corporate mergers and acquisitions,  financings,
acquisitions  of property,  use in employee  benefit plans,  or other  corporate
purposes.  The Board will determine whether, when, and on what terms the Company
should  issue  shares of Common Stock in  connection  with any of the  foregoing
purposes.

         The  Company  is  subject  to  restrictions  on its  ability  to  issue
additional  shares of Common Stock in some  situations.  The Nasdaq Stock Market
requires that the Company obtain  stockholder  approval  before it issues Common
Stock in certain circumstances, including when the number of shares to be issued
equals or exceeds  20% of the  voting  power  outstanding.  There are many other
situations,  however,  where the Board can issue shares of Common Stock  without
seeking the approval of the  stockholders.  The issuance of additional shares of
Common Stock, other than in connection with a stock split, could have a dilutive
effect on the stock ownership of current stockholders.  Stockholders do not have
pre-emptive rights to purchase any such Common Stock. Additionally, the issuance
of shares in certain  instances  may have the effect of  forestalling  a merger,
tender offer, proxy contest,  assumption of control by a holder of a large block
of the  Company's  stock or the removal of its incumbent  management.  The Board
does  not  intend  or  view  the  increase  in  authorized  Common  Stock  as an
anti-takeover  measure, nor is the Company aware of any proposed or contemplated
takeover transactions.

         Other  than  increasing  the  authorized  shares of Common  Stock  from
25,000,000 to 35,000,000, the proposed amendment in no way changes the Company's
Restated  Certificate  of  Incorporation.  The  Board  has  unanimously  adopted
resolutions  setting forth the proposed amendment to the Certificate,  declaring
its advisability  and directing that the proposed  amendment be submitted to the
stockholders  for their  approval at the annual meeting on November 21, 2000. If
adopted by the stockholders,  the amendment will become effective upon filing as
required by the General Corporation Law of Delaware.

         Required Approval

         Approval of this amendment  requires the affirmative vote of a majority
of the  stockholders  eligible to vote at the  meeting,  whether  present at the
meeting or not.

         The Board of  Directors  recommends  a vote "FOR" the  adoption  of the
amendment to the Company's Restated Certificate of Incorporation to increase the
authorized shares of Common Stock.


                                       9

<PAGE>

                                   PROPOSAL 4

                      RATIFICATION OF INDEPENDENT AUDITORS

         On  recommendation  of the Audit Committee,  the Board of Directors has
appointed  the firm of Ernst & Young LLP as the Company's  independent  auditors
for the  fiscal  year  ended  June 30,  2001,  subject  to  ratification  by the
stockholders.  Ernst & Young LLP has audited the Company's financial  statements
since  fiscal  1992.  Representatives  of Ernst & Young LLP are  expected  to be
present at the Company's Annual Meeting. They will have an opportunity to make a
statement,  if they  desire  to do so,  and  will be  available  to  respond  to
appropriate questions.

Required Approval

         Approval of this proposal  requires the affirmative  vote of a majority
of the shares  present in person or  represented  by proxy at the Annual Meeting
and entitled to vote on the proposal.

         The Board of Directors  recommends a vote "FOR" ratification of Ernst &
Young LLP as the Company's independent auditors.


                                OTHER INFORMATION

         A copy of the  Company's  Annual  Report on Form  10-KSB for the fiscal
year ended June 30, 2000 is enclosed with this proxy statement.


                              STOCKHOLDER PROPOSALS

         The deadline for submitting a stockholder proposal for inclusion in the
Company's  proxy  statement  and form of proxy for the 2001  annual  meeting  of
stockholders  is June 15,  2001,  pursuant to Rule 14a-8 of the  Securities  and
Exchange  Commission.  The deadline for  submitting a stockholder  proposal or a
nomination  for director that is not to be included in such proxy  statement and
proxy is August 29, 2001,  pursuant to Rule  14a-4(c)(1)  of the  Securities and
Exchange Commission.

                                  OTHER MATTERS

         The Company  knows of no other  business  that will be presented at the
Annual  Meeting.  If any other  business is properly  brought  before the Annual
Meeting,  it is  intended  that  proxies in the  enclosed  form will be voted in
accordance with the judgment of the persons voting the proxies.


                                         BY ORDER OF THE BOARD OF DIRECTORS,




                                         Paul E. Freiman
                                         President and Chief Executive Officer

Richmond, California
October 13, 2000


         YOU ARE CORDIALLY  INVITED TO ATTEND THE MEETING IN PERSON.  WHETHER OR
NOT YOU PLAN TO ATTEND THE  MEETING,  YOU ARE  REQUESTED  TO SIGN AND RETURN THE
ACCOMPANYING PROXY IN THE ENCLOSED POSTPAID ENVELOPE.


                                       10


<PAGE>



                                   APPENDIX A

                              AMENDED AND RESTATED
                       NEUROBIOLOGICAL TECHNOLOGIES, INC.
                          EMPLOYEE STOCK PURCHASE PLAN
                       (as amended through September 2000)


1.  PURPOSE OF THE PLAN.

         The Plan was adopted by the  Company's  Board of  Directors on December
15, 1993, approved by the Company's stockholders in January 1994 and amended and
restated by the Company's Board of Directors on August 22, 1996, and approved by
the stockholders on November 14, 1996.

         The  purpose  of the  Plan is to  provide  Eligible  Employees  with an
opportunity to increase their proprietary interest in the success of the Company
by  purchasing  Stock from the  Company on  favorable  terms and to pay for such
purchases  through  payroll  deductions.  The Plan is intended to qualify  under
section 423 of the Internal Revenue Code of 1986, as amended.


2.  ADMINISTRATION OF THE PLAN.

              (a)  The  Committee.   The  Plan  shall  be  administered  by  the
Committee. The interpretation and construction by the Committee of any provision
of the Plan or of any right to purchase  Stock  granted  under the Plan shall be
conclusive and binding on all persons.

              (b) Rules and Forms.  The Committee may adopt such rules and forms
under the Plan as it considers appropriate.


3.  ENROLLMENT AND PARTICIPATION.


         (a)  Offering  Periods.  While the Plan is in effect,  two  overlapping
Offering  Periods shall  commence in each calendar  year.  The Offering  Periods
shall consist of the 24-month periods commencing on each January 1 and July 1.


         (b) Accumulation Periods. While the Plan is in effect, two Accumulation
Periods shall  commence in each calendar year.  The  Accumulation  Periods shall
consist of the six-month periods commencing on each January 1 and July 1.


         (c) Enrollment.  Any individual who, on the day preceding the first day
of an Offering Period,  qualifies as an Eligible  Employee may elect to become a
Participant  in the Plan for such Offering  Period by executing  the  enrollment
form prescribed for this purpose by the Committee.  The enrollment form shall be
filed with the  Company  not later than one week prior to the last  working  day
prior to the commencement of such Offering Period.


         (d) Duration of Participation. Once enrolled in the Plan, a Participant
shall continue to participate until he or she ceases to be an Eligible Employee,
withdraws from the Plan or reaches the end of the  Accumulation  Period in which
he  or  she   discontinued   contributions.   A  Participant  who   discontinued
contributions  under  Section 4(d) or withdrew  from the Plan under Section 5(a)
may again become a Participant,  if he or she then is an Eligible  Employee,  by
following the procedure described in Subsection (c) above.


                                      A-1


<PAGE>

         (e)  Applicable  Offering  Period.  For  purposes  of  calculating  the
Purchase  Price under  Section 7(b),  the  applicable  Offering  Period shall be
determined as follows:


              (i) Once a  Participant  is  enrolled  in the Plan for an Offering
Period,  such  Offering  Period shall  continue to apply to him or her until the
earliest  of (A)  the  end of such  Offering  Period,  (B) the end of his or her
participation  under  Subsection (d) above or (C)  reenrollment  in a subsequent
Offering Period under Paragraph (ii) below.


              (ii) In the event that the Fair Market  Value of Stock on the last
trading  day  before  the  commencement  of the  Offering  Period  in which  the
Participant  is  enrolled  is higher  than on the last  trading  day  before the
commencement  of  any  subsequent   Offering  Period,   the  Participant   shall
automatically be re-enrolled for such subsequent Offering Period.


              (iii) When a Participant reaches the end of an Offering Period but
his  or  her   participation  is  to  continue,   then  such  Participant  shall
automatically be re-enrolled for the Offering Period that commences  immediately
after the end of the prior Offering Period.


4.       EMPLOYEE CONTRIBUTIONS.


         (a) Frequency of Payroll Deductions.  A Participant may purchase shares
of  Stock  under  the  Plan  solely  by means  of  payroll  deductions.  Payroll
deductions,  as designated by the Participant  pursuant to Subsection (b) below,
shall occur on each payday during participation in the Plan.


         (b) Amount of Payroll Deductions.  An Eligible Employee shall designate
on the  enrollment  form the portion of his or her  Compensation  that he or she
elects to have withheld for the purchase of Stock. Such portion shall be a whole
percentage  of the Eligible  Employee's  Compensation,  but not less than 1% nor
more than 10%.


         (c) Changing  Withholding  Rate. If a Participant  wishes to change the
rate of payroll withholding, he or she may do so by filing a new enrollment form
with the Company not later than one week prior to the last  working day prior to
the  commencement  of the  Accumulation  Period for which  such  change is to be
effective.


         (d)  Discontinuing  Payroll  Deductions.  If a  Participant  wishes  to
discontinue employee contributions entirely, he or she may do so by filing a new
enrollment  form  at any  time.  Payroll  withholding  shall  cease  as  soon as
reasonably practicable after such form has been received by the Company.


5.       WITHDRAWAL FROM THE PLAN.


         (a)  Withdrawal.  A Participant  may elect to withdraw from the Plan by
filing the  prescribed  form with the Company at any time before the last day of
an Accumulation Period. As soon as reasonably  practicable  thereafter,  payroll
deductions shall cease and the entire amount credited to the Participant's  Plan
Account shall be refunded to him or her in cash,  without  interest.  No partial
withdrawals shall be permitted.


         (b)  Re-Enrollment  After  Withdrawal.  A  former  Participant  who has
withdrawn from the Plan shall not be a Participant until he or she re-enrolls in
the Plan under Section 3(b).


                                      A-2


<PAGE>


6.       TERMINATION OF EMPLOYMENT OR DEATH.


         (a) Termination of Employment. Termination of employment as an Eligible
Employee  for any  reason,  including  death,  shall be treated as an  automatic
withdrawal from the Plan under Section 5(a). (A transfer from one  Participating
Company to another shall not be treated as a termination of employment.)


         (b) Death. In the event of the Participant's death, the amount credited
to his or her Plan Account shall be paid to a  beneficiary  designated by him or
her for this purpose on the  prescribed  form or, if none, to the  Participant's
estate.  Such form shall be valid only if it was filed with the  Company  before
the Participant's death.


7.       PLAN ACCOUNTS AND PURCHASE OF SHARES.


         (a) Plan  Accounts.  The Company  shall  maintain a Plan Account on its
books in the name of each  Participant.  Whenever an amount is deducted from the
Participant's  Compensation under the Plan, such amount shall be credited to the
Participant's Plan Account. No interest shall be credited to Plan Accounts.


         (b)  Purchase  Price.  The  Purchase  Price  for  each  share  of Stock
purchased at the close of an Accumulation Period shall be the lower of:


              (i) 85% of the Fair Market Value of such share on the last trading
day before the  commencement  of the applicable  Offering  Period (as determined
under Section 3(e)); or


              (ii)  85% of the  Fair  Market  Value  of such  share  on the last
trading day in such Accumulation Period.


         (c) Number of Shares Purchased. As of the last day of each Accumulation
Period,  each Participant shall be deemed to have elected to purchase the number
of shares of Stock calculated in accordance with this Subsection (c), unless the
Participant has previously  elected to withdraw from the Plan in accordance with
Section 5(a). The amount then in the Participant's Plan Account shall be divided
by the Purchase Price,  and the number of shares that results shall be purchased
from the Company with the funds in the Participant's Plan Account. The foregoing
notwithstanding,  no  Participant  shall  purchase  more than a maximum of 2,500
shares of Stock with respect to any  Accumulation  Period nor shares of Stock in
excess of the  amounts  set forth in  Sections 8 and 12(a).  The  Committee  may
determine  with  respect  to all  Participants  that any  fractional  share,  as
calculated  under this  Subsection  (c), shall be rounded down to the next lower
whole share.


         (d)  Available  Shares  Insufficient.  In the event that the  aggregate
number of shares that all Participants  elect to purchase during an Accumulation
Period  exceeds the maximum  number of shares  remaining  available for issuance
under  Section  12(a),  then the number of shares to which each  Participant  is
entitled shall be determined by multiplying  the number of shares  available for
issuance by a fraction, the numerator of which is the number of shares that such
Participant  has elected to purchase and the  denominator of which is the number
of shares that all Participants have elected to purchase.


         (e) Issuance of Stock.  Certificates  representing  the shares of Stock
purchased by a Participant  under the Plan shall be issued to him or her as soon
as reasonably practicable after the close of the applicable Accumulation Period,
except that the Committee may determine  that such shares shall be held for each
Participant's  benefit  by a broker  designated  by the  Committee  (unless  the
Participant has elected that  certificates be issued to him or her).  Shares may
be  registered  in the name of the  Participant  or  jointly  in the name of the
Participant and his or her spouse as joint tenants with right of survivorship or
as community property.


                                      A-3


<PAGE>


         (f) Unused Cash Balances. An amount remaining in the Participant's Plan
Account that  represents the Purchase  Price for any  fractional  share shall be
carried over in the Participant's Plan Account to the next Accumulation  Period.
Any amount  remaining in the  Participant's  Plan Account  that  represents  the
Purchase  Price for  whole  shares  that  could  not be  purchased  by reason of
Subsection  (c) above or Section 12(a) shall be refunded to the  Participant  in
cash, without interest.


8.       LIMITATIONS ON STOCK OWNERSHIP.


Any other provision of the Plan notwithstanding, no Participant shall be granted
a right to purchase Stock under the Plan if:

         (a) Such Participant, immediately after his or her election to purchase
such Stock, would own stock possessing more than 5% of the total combined voting
power  or  value  of all  classes  of stock  of the  Company  or any  parent  or
Subsidiary of the Company; or


         (b) Under the terms of the Plan, such Participant's  rights to purchase
stock under this and all other  qualified  employee  stock purchase plans of the
Company or any parent or  Subsidiary  of the Company would accrue at a rate that
exceeds  $25,000 of the fair market value of such stock  (determined at the time
when such  right is  granted)  for each  calendar  year for which  such right or
option is outstanding at any time.

         Ownership of stock shall be determined  after applying the  attribution
rules of section  424(d) of the Internal  Revenue Code of 1986, as amended.  For
purposes of this  Section 8, each  Participant  shall be  considered  to own any
stock that he or she has a right or option to  purchase  under this or any other
plan,  and each  Participant  shall be  considered to have the right to purchase
2,500 shares of Stock under this Plan with respect to each Accumulation Period.


9.       RIGHTS NOT TRANSFERABLE.

         The  rights of any  Participant  under the Plan,  or any  Participant's
interest  in any Stock or moneys  to which he or she may be  entitled  under the
Plan,  shall not be  transferable  by voluntary or involuntary  assignment or by
operation of law, or in any other manner other than by  beneficiary  designation
or the laws of descent and distribution. If a Participant in any manner attempts
to transfer,  assign or otherwise  encumber his or her rights or interest  under
the Plan,  other than by  beneficiary  designation  or the laws of  descent  and
distribution,  then such act shall be treated as an election by the  Participant
to withdraw from the Plan under Section 5(a).

10.      NO RIGHTS AS AN EMPLOYEE.

         Nothing in the Plan shall be  construed to give any person the right to
remain in the employ of a  Participating  Company.  Each  Participating  Company
reserves the right to terminate the  employment of any person at any time,  with
or without cause.


11.      NO RIGHTS AS A STOCKHOLDER.

         A Participant shall have no rights as a stockholder with respect to any
shares that he or she has purchased, or may have a right to purchase,  under the
Plan until the date of issuance of a stock certificate for such shares.


12.      STOCK OFFERED UNDER THE PLAN.


         (a)  Authorized  Shares.  The  aggregate  number  of  shares  of  Stock
available  for purchase  under the Plan shall be 300,000,  subject to adjustment
pursuant to this Section 12.


                                      A-4


<PAGE>

         (b) Anti-Dilution Adjustments.  The aggregate number of shares of Stock
offered under the Plan, the 2,500 share limitation described in Section 7(c) and
the price of shares  that any  Participant  has  elected  to  purchase  shall be
adjusted  proportionately  by the  Committee for any increase or decrease in the
number  of  outstanding   shares  of  Stock  resulting  from  a  subdivision  or
consolidation of shares, the payment of a stock dividend,  any other increase or
decrease in such shares effected  without receipt or payment of consideration by
the Company or the  distribution  of the shares of a Subsidiary to the Company's
stockholders.


         (c)  Reorganizations.  In the event of a dissolution  or liquidation of
the Company,  or a merger or consolidation to which the Company is a constituent
corporation,  the Plan shall terminate unless the plan of merger,  consolidation
or reorganization  provides  otherwise,  and all amounts that have been withheld
but not yet applied to  purchase  Stock  hereunder  shall be  refunded,  without
interest.  The Plan shall in no event be  construed  to  restrict in any way the
Company's right to undertake a dissolution,  liquidation,  merger, consolidation
or other reorganization.


13.      AMENDMENT OR DISCONTINUANCE.

         The  Board of  Directors  shall  have the right to  amend,  suspend  or
terminate the Plan at any time and without notice. Except as provided in Section
12, any increase in the  aggregate  number of shares of Stock to be issued under
the Plan shall be  subject  to  approval  by a vote of the  stockholders  of the
Company.  In  addition,  any other  amendment  of the Plan  shall be  subject to
approval by a vote of the  stockholders of the Company to the extent required by
an applicable law or regulation.


14.      DEFINITIONS.

         (a)  "Accumulation  Period"  means  a  six-month  period  during  which
contributions  may be made  toward  the  purchase  of Stock  under the Plan,  as
determined pursuant to Section 3(b).

         (b) "Board of  Directors"  means the Board of Directors of the Company,
as constituted from time to time.

         (c) "Committee" means a committee of the Board of Directors, consisting
of one or more directors appointed by the Board of Directors.

         (d)  "Company"  means  Neurobiological  Technologies,  Inc., a Delaware
corporation.

         (e)  "Compensation"  means  the  total  compensation  paid in cash to a
Participant by a Participating  Company,  including  salaries,  wages,  bonuses,
incentive  compensation,  commissions and overtime pay, but excluding  moving or
relocation  allowances,  car allowances,  imputed income attributable to cars or
life insurance,  taxable fringe benefits and similar items, all as determined by
the Committee.


         (f) "Eligible Employee" means any employee of a Participating Company:

              (i) Whose  customary  employment  is for more than five months per
calendar year and for more than 20 hours per week; and


              (ii) Who has been an employee of a  Participating  Company for not
less than three consecutive months.


         (g)  "Fair  Market  Value"  shall  mean  the  market  price  of  Stock,
determined by the Committee as follows:


                                      A-5


<PAGE>

              (i) If Stock was traded  over-the-counter  on the date in question
but was not traded on the Nasdaq  Stock  Market or the Nasdaq  National  Market,
then the Fair Market Value shall be equal to the mean between the last  reported
representative  bid and  asked  prices  quoted  for such  date by the  principal
automated  inter-dealer  quotation  system on which  Stock is quoted  or, if the
Stock is not quoted on any such system,  by the "Pink  Sheets"  published by the
National Quotation Bureau, Inc.;


              (ii) If Stock was traded  over-the-counter on the date in question
and was traded on the Nasdaq Stock Market or the Nasdaq  National  Market,  then
the Fair Market  Value shall be equal to the  last-transaction  price quoted for
such date by the Nasdaq Stock Market or the Nasdaq National Market;


              (iii) If the Stock was traded on a stock  exchange  on the date in
question,  then the Fair  Market  Value  shall  be  equal to the  closing  price
reported by the applicable composite transactions report for such date; and


              (iv) If none of the foregoing  provisions is applicable,  then the
Fair Market  Value shall be  determined  by the  Committee in good faith on such
basis as it deems appropriate.

Whenever possible, the determination of Fair Market Value by the Committee shall
be based on the  prices  reported  in the  Western  Edition  of The Wall  Street
Journal. Such determination shall be conclusive and binding on all persons.


         (h) "Offering Period" means a 24-month period with respect to which the
right to purchase Stock may be granted under the Plan, as determined pursuant to
Section 3(a).

         (i) "Participant"  means an Eligible Employee who elects to participate
in the Plan, as provided in Section 3(c).

         (j)  "Participating  Company"  means the  Company  and each  present or
future Subsidiary, except Subsidiaries excluded by the Committee.

         (k) "Plan" means this Neurobiological Technologies, Inc. Employee Stock
Purchase Plan, as amended from time to time.

         (l) "Plan Account" means the account  established for each  Participant
pursuant to Section 6(a).

         (m) Purchase Price" means the price at which  Participants may purchase
Stock under the Plan, as determined pursuant to Section 7(b).

         (n) "Stock" means the Common Stock of the Company.

         (o) "Subsidiary" means a corporation, 50% or more of the total combined
voting  power of all  classes  of stock of which is owned by the  Company  or by
another Subsidiary.


                                      A-6


<PAGE>


15.      EXECUTION.

         To record the  amendment  and  restatement  of the Plan by the Board of
Directors,  the  Company  has  caused its duly  authorized  officer to affix the
corporate name and seal hereto.


                                     NEUROBIOLOGICAL TECHNOLOGIES, INC.


                                     By    /s/ Paul E. Freiman
                                       -----------------------------------------
                                           President and Chief Executive Officer




                                      A-7


<PAGE>



                                   APPENDIX B

                             AUDIT COMMITTEE CHARTER

Purposes:

The purposes of the audit committee are to:

Monitor the integrity of the financial statements of the company.

Oversee the independence of the company's independent auditor.

Recommend to the board of directors  the selection of the  independent  auditor,
evaluate  the  independent   auditor  and,  where  appropriate,   recommend  the
replacement of the independent auditor; it being understood that the independent
auditor  is  ultimately  accountable  to the  board of  directors  and the audit
committee,  and that the board of  directors  and the audit  committee  have the
ultimate   authority  and   responsibility   to  select,   evaluate  and,  where
appropriate,  replace the  independent  auditor  (or to propose the  independent
auditor for stockholder approval).

Composition:

The audit committee shall be composed of three or more directors,  as determined
by the board of directors,  each of whom shall be to meet the  independence  and
financial  literacy  requirements  of Nasdaq and at least one of whom shall have
past  employment  experience in finance or  accounting,  requisite  professional
certification in accounting,  or any other  comparable  experience or background
which results in the individual's financial  sophistication,  including being or
having been a chief executive  officer,  chief financial officer or other senior
officer with financial oversight responsibilities.

Unless a chair is designated by the board of  directors,  the committee  members
may appoint their own chair by majority vote.

Responsibilities:

Recommend to the board of directors  the selection of the  independent  auditor,
which shall  ultimately be accountable  to the audit  committee and the board of
directors.

Evaluate the written  disclosures  and the letter that the  independent  auditor
submits  to  the  audit  committee  regarding  the  auditor's   independence  in
accordance  with  Independence  Standards  Board  Standard  No. 1,  discuss such
reports  with the  auditor  and,  if so  determined  by the audit  committee  in
response to such reports, recommend that the board of directors take appropriate
action to oversee the independence of the independent auditor.

Discuss with the independent auditor the matters required to be discussed by SAS
61, as it may be modified or supplemented.

Meet with  management  and the  independent  auditor to review and  discuss  the
annual  financial  statements and the report of the independent  auditor thereon
and, to the extent the independent auditor or management brings any such matters
to  the  attention  of  the  audit  committee,  to  discuss  significant  issues
encountered in the course of the audit work, including restrictions on the scope
of  activities,  access to  required  information  or the  adequacy  of internal
controls.

Review the management letter delivered by the independent  auditor in connection
with the audit.

Following such reviews and discussions, if so determined by the audit committee,
recommend  to the board of directors  that the annual  financial  statements  be
included in the company's annual report.


<PAGE>


Meet quarterly with management and the independent auditor to review and discuss
the quarterly  financial  statements;  provided that this  responsibility may be
delegated to the chairman of the audit committee.

Meet at least once each year in separate  executive sessions with management and
the independent auditor to discuss matters that the committee or either of these
groups believes could significantly  affect the financial  statements and should
be discussed privately.

Have such meetings with management as the audit  committee deems  appropriate to
discuss  significant  financial  risk  exposures  facing the company,  and steps
management has taken to monitor and control such exposures.

Review significant changes to the company's accounting  principles and practices
proposed by the independent auditor or management.

Evaluate the performance of the independent auditor and, if so determined by the
audit  committee,  recommend  to  the  board  of  directors  replacement  of the
independent auditor.

At the  request  of company  counsel,  review  with  company  counsel  legal and
regulatory matters that may have a significant impact on the company's financial
statements, compliance policies or programs.

Conduct or authorize such inquiries into matters within the committee's scope of
responsibility  as the  committee  deems  appropriate.  The  committee  shall be
empowered to retain independent counsel and other professionals to assist in the
conduct of any such inquiries.

Provide  minutes of audit  committee  meetings  to the board of  directors,  and
report to the board of directors  on any  significant  matters  arising from the
committee's work.

At least  annually,  review and  reassess  this  charter  and,  if  appropriate,
recommend proposed changes to the board of directors.

Prepare  the  report  required  by the  rules  of the  Securities  and  Exchange
Commission to be included in the company's annual proxy statement.

It is not the  responsibility  of the audit committee to plan or conduct audits,
or to determine  whether the  company's  financial  statements  are complete and
accurate or in accordance with generally accepted accounting  principles.  It is
not the responsibility of the audit committee to conduct  inquiries,  to resolve
disagreements,  if any, between  management and the independent  auditor,  or to
assure  compliance  with laws,  regulations  or company  compliance  policies or
programs.


<PAGE>

--------------------------------------------------------------------------------

PROXY                    NEUROBIOLOGICAL TECHNOLOGIES, INC.                PROXY

                                      PROXY
          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

     The  undersigned  hereby  appoints  Paul E. Freiman and Stephen C. Ferruolo
proxies,  and hereby authorizes each of them to represent and vote as designated
on  the  other  side,  all  the shares of stock of Neurobiological Technologies,
Inc.  standing  in  the  name  of  the  undersigned  with  all  powers which the
undersigned  would  possess  if present at the Annual Meeting of Stockholders of
the company to be held November 21, 2000 or any adjournment thereof.

       (Continued, and to be marked, dated and signed, on the other side)

--------------------------------------------------------------------------------
                            - FOLD AND DETACH HERE -


<PAGE>
<TABLE>
<CAPTION>
----------------------------------------------------------------------------------------------------------------------------------
<S>                                          <C>                                                                 <C>

                                                                                                                 Please mark    [X]
                                                                                                                 your votes
                                                                                                                 as indicated in
                                                                                                                 this example

ITEM 1--ELECTION OF             WITHHOLD
        DIRECTORS          FOR   FOR ALL                                                                     FOR  AGAINST  ABSTAIN
        Nominees:          [ ]     [ ]       ITEM 2--APPROVAL OF AMENDMENT TO EMPLOYEE STOCK PURCHASE PLAN   [ ]    [ ]      [ ]
        Paul E. Freiman,
        Theodore L.
        Eliot, Jr.,
        Abraham E. Cohen,                    ITEM 3--APPROVAL OF AMENDMENT TO RESTATED CERTIFICATE OF        [ ]    [ ]      [ ]
        Abraham D. Sofaer,                           INCORPORATION
        Enoch Callaway, M.D.,
        John B. Stuppin
                                             ITEM 4--RATIFICATION OF APPOINTMENT OF INDEPENDENT AUDITORS     [ ]    [ ]      [ ]
WITHHELD FOR: (Write that nominee's name
in the space provided below.)


-----------------------------------------



Signature(s) ---------------------------------------------------------                                      Dated --------- , 2000

         Please date and sign exactly as name appears hereon.  Joint owners should each sign. When signing as attorney,  executor,
administrator, trustee or guardian, please give full title as such.

----------------------------------------------------------------------------------------------------------------------------------
                                                     - FOLD AND DETACH HERE -

</TABLE>



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