BIOSEPRA INC
DEF 14A, 1997-04-11
MISCELLANEOUS CHEMICAL PRODUCTS
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<PAGE>   1
 
                            SCHEDULE 14A INFORMATION
 
          PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES
                  EXCHANGE ACT OF 1934 (AMENDMENT NO.       )
 
FILED BY THE REGISTRANT [X]       FILED BY A PARTY OTHER THAN THE REGISTRANT [ ]
 
- --------------------------------------------------------------------------------
 
Check the appropriate box:
[ ] Preliminary Proxy Statement
[X] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to sec.240.14a-11(c) or sec.240.14a-12
[ ] Confidential, for Use of the Commission Only (as permitted by Rule
    14a-6(e)(2))
 
                                 BioSepra Inc.
                (Name of Registrant as Specified In Its Charter)
 
                                 BioSepra Inc.
                   (Name of Person(s) Filing Proxy Statement)
 
PAYMENT OF FILING FEE (CHECK THE APPROPRIATE BOX):
[X] No fee required.
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
 
    1) Title of each class of securities to which transaction applies:
 
    2) Aggregate number of securities to which transaction applies:
 
    3) Per unit price or other underlying value of transaction computed pursuant
       to Exchange Act Rule 0-11 (Set forth the amount on which the filing fee
       is calculated and state how it was determined):
 
    4) Proposed maximum aggregate value of transaction:
 
    5) Total fee paid:
 
[ ] Fee paid previously with preliminary materials.
 
[ ] Check box if any part of the fee is offset as provided by Exchange Act Rule
    0-11(a)(2) and identify the filing for which the offsetting fee was paid
    previously. Identify the previous filing by registration statement number,
    or the Form or Schedule and the date of its filing.
 
    1) Amount Previously Paid:
 
    2) Form, Schedule or Registration Statement No.:
 
    3) Filing Party:
 
    4) Date Filed:
 
- --------------------------------------------------------------------------------
<PAGE>   2
 
                                 BIOSEPRA INC.
                                111 LOCKE DRIVE
                        MARLBOROUGH, MASSACHUSETTS 01752
 
                 NOTICE OF 1997 ANNUAL MEETING OF STOCKHOLDERS
 
                           TO BE HELD ON MAY 14, 1997
 
     The 1997 Annual Meeting of Stockholders of BioSepra Inc. (the "Company")
will be held at Hale and Dorr LLP, 60 State Street, Boston, Massachusetts, on
Wednesday, May 14, 1997 at 10:30 a.m., local time, to consider and act upon the
following matters:
 
     1. To set the number of directors at eight and to elect eight directors to
        serve until the next Annual Meeting of Stockholders.
 
     2. To approve the Company's 1997 Employee Stock Purchase Plan.
 
     3. To approve the Company's 1997 Stock Incentive Plan.
 
     4. To transact such other business as may properly come before the meeting
        or any adjournment thereof.
 
     Stockholders of record at the close of business on April 1, 1997 are
entitled to notice of, and to vote at, the meeting. The stock transfer books of
the Company will remain open for the purchase and sale of the Company's Common
Stock.
 
     All stockholders are cordially invited to attend the meeting.
 
                                          By Order of the Board of Directors
 
                                          ROBERT F. SCUMACI, Secretary
Marlborough, Massachusetts
April 11, 1997
 
     WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE AND
SIGN THE ENCLOSED PROXY CARD AND PROMPTLY MAIL IT IN THE ENCLOSED ENVELOPE IN
ORDER TO ASSURE REPRESENTATION OF YOUR SHARES AT THE MEETING. NO POSTAGE NEED BE
AFFIXED IF THE PROXY CARD IS MAILED IN THE UNITED STATES.
<PAGE>   3
 
                                 BIOSEPRA INC.
                                111 LOCKE DRIVE
                        MARLBOROUGH, MASSACHUSETTS 01752
 
          PROXY STATEMENT FOR THE 1997 ANNUAL MEETING OF STOCKHOLDERS
 
                           TO BE HELD ON MAY 14, 1997
 
     This Proxy Statement is furnished in connection with the solicitation of
proxies by the Board of Directors of BioSepra Inc. (the "Company") for use at
the 1997 Annual Meeting of Stockholders to be held on May 14, 1997 and at any
adjournment or adjournments of that meeting. All proxies will be voted in
accordance with the instructions contained therein, and if no choice is
specified, the proxies will be voted in favor of the matters set forth in the
accompanying Notice of Meeting. Any proxy may be revoked by a stockholder at any
time before it is exercised by delivery of written revocation to the Secretary
of the Company.
 
     The Company's Annual Report for the year ended December 31, 1996 is being
mailed to stockholders with the mailing of this Notice and Proxy Statement on or
about April 11, 1997.
 
     A COPY OF THE COMPANY'S ANNUAL REPORT ON FORM 10-K FOR THE YEAR ENDED
DECEMBER 31, 1996, AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION, EXCEPT
FOR EXHIBITS, WILL BE FURNISHED WITHOUT CHARGE TO ANY STOCKHOLDER UPON WRITTEN
REQUEST OF THE DIRECTOR OF FINANCE, BIOSEPRA INC., 111 LOCKE DRIVE, MARLBOROUGH,
MASSACHUSETTS 01752.
 
VOTING SECURITIES AND VOTES REQUIRED
 
     On April 1, 1997, the record date for the determination of stockholders
entitled to notice of and to vote at the meeting, there were outstanding and
entitled to vote an aggregate of 8,415,936 shares of Common Stock of the
Company, $.01 par value per share ("Common Stock"). Each share is entitled to
one vote.
 
     Under the Company's Bylaws, the holders of a majority of the shares of
Common Stock issued, outstanding and entitled to vote on any matter shall
constitute a quorum with respect to that matter at the Annual Meeting. Shares of
Common Stock present in person or represented by proxy (including shares which
abstain or do not vote with respect to one or more of the matters presented for
stockholder approval) will be counted for purposes of determining whether a
quorum is present.
 
     The affirmative vote of the holders of a plurality of votes cast by the
stockholders entitled to vote at the Annual Meeting is required for the election
of directors. The affirmative vote of the holders of a majority of the shares of
Common Stock voting on the matter is required for the approval of each of the
other matters to be voted upon.
 
     Shares which abstain from voting as to a particular matter, and shares held
in "street name" by brokers or nominees, who indicate on their proxies that they
do not have discretionary authority to vote such shares as to a particular
matter, will not be counted as votes in favor of such matter, and will also not
be counted as votes cast or shares voting on such matter. Accordingly,
abstentions and "broker non-votes" on a matter that requires the affirmative
vote of a certain percentage of the votes cast or shares voting on a matter,
such as the election of directors, the approval of the 1997 Employee Stock
Purchase Plan and the approval of the 1997 Stock Incentive Plan, have no effect
on the voting of such matter.
<PAGE>   4
 
STOCK OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
     The following table sets forth certain information, as of January 31, 1997
or such later date as is noted, with respect to the beneficial ownership of the
Company's Common Stock by (i) each person known by the Company to own
beneficially more than 5% of the outstanding shares of Common Stock; (ii) each
director and nominee for director; (iii) each executive officer named below in
the Summary Compensation Table under the heading "Compensation of Executive
Officers" and (iv) all directors and executive officers of the Company as a
group.
 
     The number of shares of Common Stock beneficially owned by each director or
executive officer is determined under the rules of the Securities and Exchange
Commission, and the information is not necessarily indicative of beneficial
ownership for any other purpose. Under such rules, beneficial ownership includes
any shares as to which the individual has sole or shared voting power or
investment power and also any shares which the individual has the right to
acquire within 60 days after January 31, 1997 through the exercise of any stock
option or other right. Unless otherwise indicated, each person has sole
investment and voting power (or shares such power with his or her spouse) with
respect to the shares set forth in the following table. The inclusion herein of
any shares deemed beneficially owned does not constitute an admission of
beneficial ownership of those shares.
 
<TABLE>
<CAPTION>
                                                                   SHARES OF     
                                                                  COMMON STOCK    PERCENTAGE OF      
                                                                  BENEFICIALLY     COMMON STOCK
NAME AND ADDRESS                                                     OWNED         OUTSTANDING
- ----------------                                                  ------------    -------------
<S>                                                               <C>                <C>
Sepracor Inc....................................................    5,369,788        63.8%
  111 Locke Drive
  Marlborough, MA 01752
Tudor Investment Corporation(1).................................      849,000        10.1
  One Liberty Plaza (51st Floor)
  New York, NY 10006
Timothy J. Barberich(2).........................................       26,000         *
Jean-Marie Vogel(3).............................................       95,100        1.1
William E. Rich, Ph.D.(4).......................................       30,680         *
William M. Cousins, Jr.(4)......................................        7,000         *
Alexander M. Klibanov, Ph.D.(4).................................       10,500         *
Riccardo Pigliucci(4)...........................................        4,000         *
Paul A. Looney(4)...............................................        7,000         *
David P. Southwell..............................................            0         *
Egisto Boschetti, Ph.D.(4)......................................       36,000         *
James A. Prendergast............................................            0         *
Therese Bourdy(4)...............................................        3,400         *
Gary G. Gaudet(5)...............................................        6,290         *
All directors and executive officers as a group (12
  persons)(6)...................................................      225,970        2.6
</TABLE>
 
- ---------------
 *  Represents holdings of less than one percent.
 
(1) Based on information furnished to the Company on March 14, 1997.
 
(2) Includes 24,000 shares of Common Stock which Mr. Barberich has the right to
    acquire within 60 days after January 31, 1997 upon exercise of outstanding
    stock options.
 
                                        2
<PAGE>   5
 
(3) Includes 80,100 shares of Common Stock which Mr. Vogel has the right to
    acquire within 60 days after January 31, 1997 upon exercise of outstanding
    stock options.
 
(4) Represents shares of Common Stock which each such person has the right to
    acquire within 60 days after January 31, 1997 upon exercise of outstanding
    stock options.
 
(5) Includes 4,100 shares of Common Stock which Mr. Gaudet has the right to
    acquire within 60 days after January 31, 1997 upon exercise of outstanding
    stock options.
 
(6) Includes an aggregate of 206,780 shares of Common Stock which all executive
    officers and directors have the right to acquire within 60 days after
    January 31, 1997 upon exercise of outstanding stock options.
 
                             ELECTION OF DIRECTORS
 
     The persons named in the enclosed proxy will vote to elect as directors the
eight nominees named below, unless the proxy is marked otherwise. If a
stockholder returns a proxy without contrary instructions the persons named as
proxies will vote to elect as directors the director nominees named below, each
of whom is currently a member of the Board of Directors of the Company.
 
     Each director will be elected to hold office until the 1998 Annual Meeting
of Stockholders and until his successor is duly elected and qualified. All of
the nominees have indicated their willingness to serve, if elected; however, if
any nominee should be unable to serve, the shares of Common Stock represented by
proxies may be voted for a substitute nominee designated by the Board of
Directors.
 
     There are no family relationships between or among any officers or
directors of the Company.
 
     Set forth below are the name and age of each member of the Board of
Directors, and the positions and offices held by him, his principal occupation
and business experience during the past five years, the names of other publicly
held companies of which he serves as a director and the year of the commencement
of his term as a director of the Company. Information with respect to the number
of shares of Common Stock beneficially owned by each director, directly or
indirectly, as of January 31, 1997, appears above under the heading "Stock
Ownership of Certain Beneficial Owners and Management."
 
                             NOMINEES FOR DIRECTOR
 
     TIMOTHY J. BARBERICH, age 49, has served as a director of the Company since
its organization in 1993. Mr. Barberich was a founder of Sepracor Inc.
("Sepracor"), an emerging pharmaceutical company, and has served as President,
Chief Executive Officer and a director of Sepracor since January 1984. Sepracor
owns approximately 64% of the outstanding Common Stock of the Company. Mr.
Barberich also serves as a director of HemaSure Inc., a publicly-traded company
of which Sepracor owns approximately 37% of the outstanding common stock
("HemaSure").
 
     WILLIAM M. COUSINS, JR., age 72, has served as a director of the Company
since January 1994. Since 1965, Mr. Cousins has served as the President of
William M. Cousins, Jr., Inc., a management consulting firm. Mr. Cousins is a
member of the Board of Directors of Alba Waldensian, Inc. and Wellco
Enterprises, Inc.
 
     ALEXANDER M. KLIBANOV, PH.D., age 47, has served as a director of the
Company since January 1994. Since July 1979, Dr. Klibanov has been a faculty
member of the Massachusetts Institute of Technology where he is currently
Professor of Chemistry and a member of the Biotechnology Process Engineering
Center.
 
                                        3
<PAGE>   6
 
     PAUL A. LOONEY, age 57, has served as a director of the Company since
January 1994. From 1984 to 1995, Mr. Looney served as President and Chief
Executive Officer of Corning Costar Corporation, a life science products company
and a wholly-owned subsidiary of Corning, Inc.
 
     RICCARDO PIGLIUCCI, age 50, has served as a director of the Company since
August 1995. From January 1966 to April 1995, Mr. Pigliucci served in a number
of capacities at Perkin-Elmer Corporation, a global life sciences
instrumentation company, most recently as President and Chief Operating Officer.
Since February 1996, Mr. Pigliucci has served as Chief Executive Officer of Life
Sciences International P.L.C. Since June 1995, Mr. Pigliucci has served as the
Chairman of Topometrix Corporation.
 
     WILLIAM E. RICH, PH.D., age 52, has served as a director of the Company
since its organization in December 1993. Since September 1994, Dr. Rich has
served as President and Chief Executive Officer of Ciphergen Biosystems, Inc., a
biotechnology company. From January 1994 to September 1994, Dr. Rich served as
President and Chief Executive Office of the Company. From September 1991 to
January 1994, Dr. Rich served as Senior Vice President and General Manager,
Bioseparations of Sepracor. From 1975 to 1990, Dr. Rich served in a number of
executive capacities at Dionex Corporation, a research chromatography company of
which he was a co-founder.
 
     DAVID P. SOUTHWELL, age 36, has served as a director of the Company since
January 1997. He has served as Executive Vice President, Chief Financial Officer
of Sepracor since October 1995 and served as Senior Vice President and Chief
Financial Officer of Sepracor from July 1994 to October 1995. From August 1988
until July 1994, Mr. Southwell was associated with Lehman Brothers, a securities
firm in various positions with the investment banking division, including in the
position of Vice President.
 
     JEAN-MARIE VOGEL, age 46, has served as President, Chief Executive Officer
and a director of the Company since September 1994. From January 1994 to
September 1994, Mr. Vogel served as Executive Vice President and Chief Operating
Officer of the Company. From 1992 to 1993, Mr. Vogel served as President of the
European Operations of Cuno, Inc., a supplier of filtration processes, equipment
and devices used in the production of biological drugs and food products. From
1977 to 1992, Mr. Vogel served in various capacities with Millipore Corporation
("Millipore"), a manufacturer of membrane filtration-based products, in its
international operations with experience in Asia, Latin America, the former
Soviet Union, the Middle East and Australia, including as Vice President and
General Manager of Millipore's Asian operations. Mr. Vogel is a French citizen.
 
BOARD AND COMMITTEE MEETINGS
 
     The Company has a standing Audit Committee of the Board of Directors, which
provides the opportunity for direct contact between the Company's independent
accountants and the Board. The Audit Committee has responsibility for
recommending the appointment of the Company's independent accountants, reviewing
the scope and results of audits and reviewing the Company's internal accounting
control policies and procedures. The Audit Committee held one meeting in 1996.
The members of the Audit Committee are Messrs. Cousins and Looney.
 
     The Company also has a standing Compensation Committee of the Board of
Directors, which is responsible for determining the compensation of, and
establishing compensation policies for, the executive officers of the Company.
The Compensation Committee held one meeting during 1996. The members of the
Compensation Committee are Messrs. Cousins and Looney. See "Report of the
Compensation Committee" below.
 
                                        4
<PAGE>   7
 
     The Company does not have a nominating committee or a committee serving a
similar function. Nominations are made by and through the full Board of
Directors.
 
     The Board of Directors held four meetings during 1996. Each director
attended at least 75% of the total number of meetings of the Board of Directors
and all committees of the Board on which he served.
 
COMPENSATION FOR DIRECTORS
 
     Directors who are neither officers nor employees of the Company or of any
affiliate of the Company (the "Outside Directors") receive $1,000 for each
meeting of the Board they attend and are entitled to participate in the
Company's 1994 Director Option Plan (the "Director Option Plan"), as further
described below. Directors who are officers or employees of the Company or of
any affiliate of the Company do not receive compensation for attendance at
meetings. On January 5, 1994, options to purchase an aggregate of 70,000 shares
of Common Stock at an exercise price of $2.00 per share were granted under the
Director Option Plan to the following directors: Mr. Barberich, 40,000 shares
and Mr. Cousins, Mr. Looney and Dr. Klibanov, 10,000 shares each. On May 17,
1995, options to purchase an aggregate of 8,000 shares of Common Stock at an
exercise price of $3.375 per share were granted under the Director Option Plan
to the following directors: Mr. Cousins, Mr. Looney, Dr. Klibanov and Dr. Rich.
On August 15, 1995, options to purchase 10,000 shares of Common Stock at an
exercise price of $6.125 were granted to Mr. Pigliucci, and on January 20, 1997,
options to purchase 10,000 shares of Common Stock at an exercise price of $2.875
per share were granted to Mr. Southwell, in connection with their respective
elections to the Board of Directors. On May 15, 1996, options to purchase an
aggregate of 12,000 shares of Common Stock at an exercise price of $5.375 per
share were granted under the Director Option Plan to the following directors:
Mr. Barberich, Mr. Cousins, Mr. Looney, Dr. Klibanov, Mr. Pigliucci and Dr.
Rich.
 
     In addition, on January 20, 1997, options to purchase 10,000 shares of
Common Stock, at an exercise price of $2.875 per share (the fair market value on
the date of grant) were granted pursuant to the Company's 1994 Stock Option Plan
to each of Messrs. Looney and Cousins in consideration for their services as
members of the Audit and Compensation Committees of the Board of Directors.
 
     Summary of the Director Option Plan.  Under the Director Option Plan,
options to purchase 10,000 shares of Common Stock are granted to each Director
who is not an employee of the Company or any subsidiary of the Company (an
"Eligible Director"), except for Mr. Barberich who was granted options to
purchase 40,000 shares of Common Stock upon his initial election as a director
(the "Initial Options"), and options to purchase 2,000 shares of Common Stock
are granted upon the dates on which the Eligible Director is subsequently
reelected to the Board (the "Reelection Options"). A total of 150,000 shares of
Common Stock may be issued under the Director Option Plan, subject to
adjustments as provided therein.
 
     Each Initial Option granted to a director under the Director Option Plan
will vest in five equal annual installments beginning on the first anniversary
of the date of grant, and Reelection Options granted under the Director Option
Plan will vest in two equal annual installments beginning on the first
anniversary of the date of grant. The exercise price per share will equal the
fair market value of a share of Common Stock on the date on which the option is
granted, except the exercise price per share is $2.00 for any Initial Options
granted prior to January 15, 1994. The exercise price must be paid in cash.
Options granted under the Director Option Plan are not transferable by the
optionholder except by will or by the laws of descent and distribution and are
exercisable during the lifetime of the director only while he or she is serving
as a director of the Company or within 90 days after he or she ceases to serve
as a director of the Company. No option is exercisable more than
 
                                        5
<PAGE>   8
 
ten years from the date of grant. If a director dies or becomes disabled while
he or she is serving as a director of the Company, the option is exercisable for
a one year period thereafter.
 
     The Board of Directors may suspend or discontinue the Director Option Plan
or amend it in any respect; provided, however, that without the approval of the
stockholders, no amendment may change the number of shares subject to the
Director Option Plan, change the designation of the class of directors eligible
to receive options, or materially increase the benefits accruing to participants
under the Director Option Plan. In the event of a Change of Control (as defined
in the Director Option Plan) any outstanding options shall become immediately
exercisable.
 
COMPENSATION OF EXECUTIVE OFFICERS
 
     Summary Compensation Table.  The following table sets forth certain
information with respect to the annual and long-term compensation for the last
three fiscal years of the Company's President and Chief Executive Officer and
the Company's other executive officers whose total annual salary and bonus for
1996 exceeded $100,000 (collectively, the "Named Executive Officers").
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                               LONG-TERM
                                                                              COMPENSATION
                                                                                 AWARDS
                                                                              ------------
                                                   ANNUAL COMPENSATION         SECURITIES     ALL OTHER
                                              -----------------------------    UNDERLYING    COMPENSATION
        NAME AND PRINCIPAL POSITION           YEAR   SALARY ($)   BONUS ($)   OPTIONS (#)       ($)(1)
        ---------------------------           ----   ----------   ---------   ------------   ------------
<S>                                           <C>    <C>          <C>         <C>            <C>
Jean-Marie Vogel............................  1996    $ 163,803    $65,000             0        $1,251
  President and                               1995      156,744     50,000           500           985
  Chief Executive Officer                     1994      150,000     50,000       260,000           306
 
Egisto Boschetti, Ph.D. ....................  1996    $ 133,213    $21,575        10,000        $3,992
  Executive Vice President and                1995      134,271     73,186             0         4,012
  Chief Scientific Officer                    1994      127,008     20,446        65,000             0
 
Therese Bourdy(2)...........................  1996    $ 102,022    $17,854        25,000        $1,812
  Vice President of Media                     1995       40,599      9,053        17,000             0
  Operations                                  1994           --         --            --            --
 
Gary G. Gaudet(3)...........................  1996    $ 100,739    $20,300             0        $  727
  Vice President of Sales and                 1995       82,475     18,400        20,500           280
  Marketing                                   1994           --         --            --            --
</TABLE>
 
- ---------------
(1) Represents the taxable portion of group life insurance, retirement and other
    benefits paid by the Company.
(2) Ms. Bourdy became an employee of the Company in August 1995.
(3) Mr. Gaudet became an employee of the Company in January 1995.
 
                                        6
<PAGE>   9
 
     Option Grant Table.  The following table sets forth certain information
regarding options granted during the year ended December 31, 1996 by the Company
to the Named Executive Officers.
 
                       OPTION GRANTS IN LAST FISCAL YEAR
 
<TABLE>
<CAPTION>
                                INDIVIDUAL GRANTS                                               POTENTIAL
                             -----------------------                                            REALIZABLE
                                          PERCENT OF                MARKET                   VALUE AT ASSUMED
                             NUMBER OF      TOTAL                  PRICE OF                  ANNUAL RATES OF
                             SECURITIES    OPTIONS                SECURITIES                   STOCK PRICE
                             UNDERLYING   GRANTED TO   EXERCISE   UNDERLYING                 APPRECIATION FOR
                              OPTIONS     EMPLOYEES    OR BASE     OPTIONS                    OPTION TERM(2)
                              GRANTED     IN FISCAL     PRICE      ON GRANT    EXPIRATION   ------------------
           NAME                (#)(1)      YEAR (%)     (#/SH)     DATE ($)       DATE      5% ($)    10% ($)
           ----              ----------   ----------   --------   ----------   ----------   -------   --------
<S>                          <C>          <C>          <C>        <C>          <C>          <C>       <C>
Jean-Marie Vogel...........         0           0%      $    0      $    0       --/--/--   $    --   $     --
Egisto Boschetti, Ph.D. ...    10,000         4.8%        2.75        2.75       12/11/06    17,294     43,828
Therese Bourdy.............    25,000        12.0%        2.75        2.75       12/11/06    43,237    109,570
Gary G. Gaudet.............         0           0%           0           0       --/--/--        --         --
</TABLE>
 
- ---------------
(1) Options vest in five equal annual installments beginning on the first
    anniversary of the date of grant.
(2) Amounts represent hypothetical gains that could be achieved for options if
    exercised at the end of the option term. These gains are based on assumed
    rates of stock price appreciation of 5% and 10% compounded annually from the
    date options are granted. Actual gains, if any, on stock option exercises
    will depend on the future performance of the Common Stock on the date on
    which options were exercised.
 
    Year-End Option Table.  The following table sets forth certain information
regarding stock options exercised during the year ended December 31, 1996 and
stock options held as of December 31, 1996 by the Named Executive Officers.
 
              AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND
                             YEAR-END OPTION VALUES
 
<TABLE>
<CAPTION>
                                                                                
                                                                               
                                                                              
                                                                            
                                                                             
                                                          NUMBER OF         
                                                         SECURITIES             VALUE OF
                                                         UNDERLYING            UNEXERCISED
                                                         UNEXERCISED          IN-THE-MONEY
                                                      OPTIONS AT FISCAL     OPTIONS AT FISCAL
                                                        YEAR-END (#)         YEAR-END ($)(1)
                                                      -----------------     -----------------
                                                        EXERCISABLE/          EXERCISABLE/
                                                        UNEXERCISABLE         UNEXERCISABLE
                                                      -----------------     -----------------
        <S>                                           <C>                      <C>
        Jean-Marie Vogel............................     56,100/204,400        $18,000/27,000
        Egisto Boschetti, Ph.D......................     26,000/ 49,000          7,500/11,250
        Therese Bourdy..............................      3,400/ 38,600              0/     0
        Gary G. Gaudet..............................      4,100/ 16,400              0/     0
</TABLE>
 
- ---------------
(1) Value is based on the closing sales price of the Company's Common Stock on
    the Nasdaq Stock Market on December 31, 1996 ($2.375), the last trading day
    of the Company's 1996 fiscal year, less the applicable option exercise
    price.
 
                                        7
<PAGE>   10
 
SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
 
     Based solely on its review of copies of reports filed by all officers of
the Company who are persons required to file reports ("Reporting Persons")
pursuant to Section 16(a) of the Securities Exchange Act of 1934, as amended
(the "Exchange Act") or written representations from certain Reporting Persons
that no Form 5 filing was required for such persons, the Company believes that
during fiscal 1996 all filings required to be made by its Reporting Persons were
timely made in accordance with the requirements of the Exchange Act.
 
REPORT OF THE COMPENSATION COMMITTEE
 
     The Compensation Committee of the Company, which is currently comprised of
two non-employee directors, William M. Cousins, Jr. and Paul A. Looney, is
responsible for determining the compensation package of each executive officer.
The Compensation Committee sets the compensation for executive officers and
establishes compensation policies for the Company's Chief Executive Officer and
the other executive officers of the Company, including the Named Executive
Officers.
 
     The Company's executive compensation program is designed to promote the
achievement of the Company's business goals, and, thereby, to maximize corporate
performance and stockholder returns. Executive compensation consists of a
combination of base salary, bonuses and stock-based incentives. The Compensation
Committee considers stock incentives to be a critical component of an
executive's compensation package in order to help align executive interests with
stockholder interests.
 
     Compensation Philosophy
 
     The objectives of the executive compensation program are to align
compensation with business objectives and individual performance, and to enable
the Company to attract, retain and reward executive officers who are expected to
contribute to the long-term success of the Company. The Company's executive
compensation philosophy is based on the principles of competitive and fair
compensation and sustained performance.
 
     - COMPETITIVE AND FAIR COMPENSATION
 
     The Company is committed to providing an executive compensation program
that helps attract and retain highly qualified executives. To ensure that
compensation is competitive, the Company compares its compensation practices
with those of other companies in the industry and sets its compensation
guidelines based on this review. The Company believes compensation for its
executive officers is within the range of compensation paid to executives with
comparable qualifications, experience and responsibilities in the same or
similar business and of comparable size and success. The Company also strives to
achieve equitable relationships both among the compensation of individual
officers and between the compensation of officers and other employees throughout
the organization.
 
     - SUSTAINED PERFORMANCE
 
     Executive officers are rewarded based upon corporate performance and
individual performance. Corporate performance is evaluated by reviewing the
extent to which strategic and business plan goals are met, including such
factors as achievement of operating budgets, establishment of strategic
licensing and development alliances with third parties, timely development and
commercial introduction of new processes and products and performance relative
to competitors. Individual performance is evaluated by reviewing
 
                                        8
<PAGE>   11
 
attainment of specified individual objectives and the degree to which teamwork
and Company values are fostered.
 
     In evaluating each executive officer's performance, the Company generally
conforms to the following process:
 
     - Company and individual goals and objectives generally are set at the
       beginning of the performance cycle.
 
     - At the end of the performance cycle, the accomplishment of the
       executive's goals and objectives and his contributions to the Company are
       evaluated.
 
     - The executive's performance is then compared with peers within the
       Company and the results are communicated to the executive.
 
     - The comparative results, combined with comparative compensation practices
       of other companies in the industry, is then used to determine salary and
       stock compensation levels.
 
     Annual compensation for the Company's executives generally consists of
three elements-salary, cash bonuses and stock options.
 
     The salary for executives is generally set by reviewing compensation for
competitive positions in the market and the historical compensation levels of
the executives. Increases in annual salaries and payment of bonus awards is
based on actual corporate and individual performance against targeted
performance and various subjective performance criteria. Targeted performance
criteria vary for each executive based on his area of responsibility, and may
include achievement of the operating budget for the Company as a whole or of a
business group of the Company, continued innovation in development and
commercialization of the Company's technology and products, timely development
and commercial introduction of new products or processes, implementation of
financing strategies and establishment of strategic licensing and development
alliances with third parties. Subjective performance criteria include an
executive's ability to motivate others, develop the skills necessary to grow as
the Company matures, recognize and pursue new business opportunities and
initiate programs to enhance the Company's growth and success. The Committee
does not use a specific formula based on these targeted performance and
subjective criteria, but instead makes an evaluation of each executive officer's
contributions in light of all such criteria.
 
     Compensation at the executive officer level also includes the long-term
incentives afforded by stock options. The stock option program is designed to
promote the identity of long-term interests between the Company's employees and
its shareholders and assist in the retention of executives. The size of option
grants is generally intended to reflect the executive's position with the
Company and his contributions to the Company, including his success in achieving
the individual performance criteria described above. The option program
generally uses a five-year vesting period to encourage key employees to continue
in the employ of the Company. All stock options granted to executive officers in
1996 were granted at fair market value on the date of grant. During 1996, all
current executive officers received options to purchase an aggregate of 35,000
shares of Common Stock, at a weighted average exercise price of $2.75 per share.
 
     Executive officers are also eligible to participate in the Company's 1995
Employee Stock Purchase Plan (the "Purchase Plan"). The Purchase Plan is
available to virtually all employees of the Company and generally permits
participants to purchase shares at a discount of approximately 15% from the fair
market value at the beginning or end of the applicable purchase period.
 
                                        9
<PAGE>   12
 
     Compliance with Internal Revenue Code Section 162(m).  Section 162(m) of
the Internal Revenue Code, of 1986, as amended (the "Code"), enacted in 1993,
generally disallows a tax deduction to public companies for compensation over
$1.0 million paid to the corporation's Chief Executive Officer and four other
most highly compensated executive officers. Qualifying performance compensation
will not be subject to the deduction limit if certain requirements are met. The
Company intends to structure the performance-based portion of the compensation
of its executive officers in a manner that complies with the new statute to
mitigate any disallowance of deductions.
 
     Mr. Vogel's 1996 Compensation
 
     Mr. Vogel is eligible to participate in the same executive compensation
plans available to the other executives officers of the Company. The
Compensation Committee believes that Mr. Vogel's annual compensation, including
the portion of his compensation based upon the Company's stock option program,
has been set at a level competitive with other companies in the industry.
 
     Mr. Vogel's salary for 1996 increased to $163,803 from $156,744 in 1995.
Mr. Vogel received bonus compensation of $65,000 based upon his performance and
accomplishments during 1996, which included significant improvement of the
financial performance of the Company, articulation of a long-term product and
business strategy, development of BioSepra's management team, completion by the
Company of all milestones set forth in the agreement with Beckman Instruments,
Inc., the launch and implementation of a quality instrument manufacturing
operation, the launch and implementation of a new media process development
program and the obtainment of new major customer orders for the Company's
proprietary HyperD media.
 
                                          Compensation Committee
 
                                          William M. Cousins, Jr.
                                          Paul A. Looney
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     The current members of the Compensation Committee are Messrs. Cousins and
Looney. Neither member of the Compensation Committee was at any time during
1996, or formerly, an officer or employee of the Company or any subsidiary of
the Company, nor has any member of the Compensation Committee had any
relationship with the Company requiring disclosure under Item 404 of Regulation
S-K under the Exchange Act.
 
     No executive officer of the Company has served as a director or member of
the Compensation Committee (or other committee serving an equivalent function)
of any other entity, one of whose executive officers served as a director of or
member of the Compensation Committee of the Company.
 
COMPARATIVE STOCK PERFORMANCE
 
     The comparative stock performance graph below compares the cumulative
stockholder return on the Common Stock of the Company for the period from March
25, 1994 through December 31, 1996 with the cumulative total return on (i) the
Total Return Index for the Nasdaq Stock Market (U.S. Companies) (the "Nasdaq
Composite Index") and (ii) the Hambrecht & Quist Biotechnology Index ("H&Q
Biotechnology Index") (assuming the investment of $100 in the Company's Common
Stock (at the initial public offering
 
                                       10
<PAGE>   13
 
price), the Nasdaq Composite Index and the H&Q Biotechnology Index on March 25,
1994 and reinvestment of all dividends). Measurement points are on March 25,
1994 and the last trading day of the years ended December 31, 1994, December 31,
1995 and December 31, 1996. Prior to March 25, 1994, the Company's Common Stock
was not registered under the Exchange Act.

               [Chart depicting comparative stock performance]

 
<TABLE>
<CAPTION>
                                                                                   H & Q
        Measurement Period                               NASDAQ Composite      Biotechnology
      (Fiscal Year Covered)            BioSepra Inc.           Index               Index
<S>                                  <C>                 <C>                 <C>
3/25/94                                  100.00              100.00              100.00
Dec-94                                    48.21               96.79              113.24
Dec-95                                    48.21              136.88              192.63
Dec-96                                    33.93              168.37              177.73
</TABLE>
 
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
     The Company was organized in December 1993 as a subsidiary of Sepracor.
Effective January 1, 1994, Sepracor transferred its chromatography business
including all of the outstanding shares of IBF, a subsidiary of BioSepra, to the
Company in exchange for 4,000,000 shares of Common Stock. As more fully
described below, in June 1996, Sepracor converted the outstanding principal and
interest of a loan to BioSepra into an aggregate of 1,369,788 shares of
BioSepra's Common Stock. Sepracor owns approximately 64% of the Company's Common
Stock. Under applicable provisions of the Delaware General Corporation Law,
Sepracor has the ability, acting alone, to approve any action requiring approval
of the holders of a majority of the outstanding shares of Common Stock. Mr.
Barberich and Mr. Southwell, directors of the Company, are President and Chief
Executive Officer and Executive Vice President and Chief Financial Officer of
Sepracor, respectively.
 
     Technology Transfer and License Agreement.  The Company and Sepracor
entered into a Technology Transfer and License Agreement (the "Technology
Transfer Agreement"), dated as of January 1, 1994, pursuant to which Sepracor
transferred to the Company all technology owned or controlled by Sepracor,
including trade secrets, patents and patent applications, that relates to and is
used in researching, developing or manufacturing products in the "Company
Field." The Company Field means generally the separation of biological
molecules. Further, Sepracor has granted an exclusive license to the Company for
any improvements to the transferred technology useful in the Company Field which
are developed, or otherwise acquired, by Sepracor during the period beginning on
the date of the Technology Transfer Agreement and terminating
 
                                       11
<PAGE>   14
 
on the earlier of January 1, 1998 or the acquisition of Sepracor or the Company
(the "Effective Period"). The Company has granted to Sepracor an exclusive
license to the transferred technology for the development, manufacture, use or
sale of any products within the field of chiral synthesis, chiral separations
and the development, manufacture, use or sale of chiral drugs and chiral drug
intermediates (the "Sepracor Field"), as well as a non-exclusive license to the
transferred technology for the development, manufacture, use or sale of any
products outside the Company Field. All licenses are royalty-free. Sepracor has
also granted the Company a right of first refusal to any product which Sepracor
proposes to sell, or license a third party to sell, during the Effective Period,
for use within the Company Field.
 
     Cross License Agreement.  The Company has entered into a Cross License
Agreement (the "Cross License Agreement"), dated as of January 1, 1994 with
HemaSure. Under the terms of the Cross License Agreement, HemaSure and the
Company have each granted to the other a perpetual, royalty-free and non-
exclusive right and license to technology and improvements owned or controlled
by the licensing party for use in the HemaSure Field or the Company Field,
respectively. The HemaSure Field comprises technology relating to the
development, manufacture, use or sale of medical devices for the purification of
blood, blood products or blood components and membrane filter design. The Cross
License Agreement will terminate on the earlier of January 1, 1998 or the date
that substantially all of the assets of either HemaSure or the Company have been
acquired by a third party.
 
     Corporate Services Agreement.  The Company and Sepracor entered into a
Corporate Services Agreement dated as of January 1, 1994, which provides for a
monthly fee to be paid by the Company for basic services, such as accounting,
preparation of financial statements, human resources support services, data
processing and laboratory support services provided by Sepracor. This fee was
determined by estimating Sepracor's cost of the Company's expected usage of such
basic services. The Company may purchase additional services from Sepracor for a
fixed rate based on the number of hours spent by each Sepracor employee
providing such services. For items with identifiable costs such as insurance
coverage, Sepracor charges the Company based upon costs directly attributable to
the Company. The Company believes that the charges under the Corporate Services
Agreement are reasonable and that the terms of the Corporate Services Agreement
are at least as favorable to the Company as the terms that could be obtained
from an unaffiliated third party. The agreement had an initial term of one year
and has been extended for three additional one-year terms. Sepracor retains the
right to decline to provide any services which cause an unreasonable burden to
Sepracor. The agreement permits the Company to terminate at any time following
60 days' notice to Sepracor, and automatically terminates six months after
Sepracor's ownership percentage of the Company decreases to less than 50% of the
Company's issued and outstanding shares. The aggregate payments made by the
Company to Sepracor for basic services under the agreement were $197,000 in
1995, $208,000 in 1996 and are estimated to be approximately $208,000 in 1997.
 
     Sublease Agreement.  Sepracor has entered into a Sublease Agreement with
the Company under which Sepracor subleases a portion of its facility in
Marlborough, Massachusetts to the Company. The amount payable to Sepracor under
the Sublease Agreement is equal to Sepracor's rental costs under its lease
allocable to the portion of the premises subleased to the Company plus a pro
rata allocation of the estimated facility maintenance, utilities and other
operating costs. The rental payment by the Company under this Agreement was
approximately $77,000 in 1995, $72,000 in 1996, exclusive, in both years, of
operating costs and is estimated to be approximately $75,000 in 1997.
 
     Pending Patent Litigation.  The Company and Sepracor are defendants in
three lawsuits brought by PerSeptive Biosystems, Inc. ("PerSeptive"), a
competitor of the Company, in the United States District Court for the District
of Massachusetts. In actions commenced in October 1993 and January 1995,
PerSeptive
 
                                       12
<PAGE>   15
 
has alleged that the Company's and Sepracor's manufacture and sale of HyperD
chromatography media infringe four of PerSeptive's United States patents, three
of which pertain to "perfusion" chromatography. PerSeptive is seeking
unspecified monetary damages as well as injunctive relief. In a separate action,
PerSeptive has alleged that certain statements made by Sepracor and BioSepra
with respect to the performance of HyperD media, performance of PerSeptive's
POROS media, and the internal structures of POROS and HyperD media, including
statements made in BioSepra's Prospectus dated March 24, 1994, constitute false
advertising. Two additional perfusion chromatography patents have been issued to
PerSeptive. BioSepra and Sepracor have asserted a counterclaim charging
PerSeptive with unfair competition. Sepracor has agreed to control the defense
of the litigation, and Sepracor and BioSepra share equally in expenses, net of
insurance payments. In addition, in the event of any settlement or judgment
adverse to the Company, Sepracor has agreed to indemnify the Company from and
against any damages that the Company is required to pay with respect to its
manufacture, use or sale of HyperD media products occurring prior to March 24,
1994. On April 4, 1997, the District Court ordered entry of judgment in favor of
the Company and Sepracor on PerSeptive's claims that they infringed the three
"perfusion" chromatography patents because the Court held that the "perfusion"
patents are unenforceable. As a result, PerSeptive's pending infringement claims
which relate to "perfusion" patents against the Company will be dismissed.
PerSeptive has stated that it will appeal this decision. If the District Court's
opinion is upheld on appeal, the Company and Sepracor will have prevailed in the
claims that they have infringed the three "perfusion" patents.
 
     Loan Agreement.  On March 29, 1996, the Company issued a Convertible
Subordinated Note due March 2000 (the "Note") to Sepracor providing for the
borrowing by the Company from Sepracor of up to $5,500,000 (the "Loans") at an
interest rate of 7%. The Loans, including any accrued interest thereon, were
convertible into shares of the Company's Common Stock, $.01 par value ("Common
Stock"), at the option of Sepracor at any time prior to repayment. On June 10,
1996, Sepracor converted the outstanding principal ($5,500,000), plus accrued
interest ($47,639), of the Loans into an aggregate of 1,369,788 shares of the
Company's Common Stock. As a result of the conversion of the Note, Sepracor's
ownership of the Company's outstanding Common Stock increased from approximately
58% to approximately 64%.
 
     Promissory Note.  In January 1996, the Company entered into a promissory
note for $350,000, or so much of such sum as shall have been advanced by
Sepracor. This amount is payable to Sepracor over sixty monthly installments and
does not bear interest. The Company used the funds for leasehold improvements in
its office space.
 
                                APPROVAL OF 1997
                          EMPLOYEE STOCK PURCHASE PLAN
 
     The Board of Directors believes it is in the best interests of the Company
to encourage stock ownership by employees of the Company. Accordingly, on March
28, 1997, the Board of Directors adopted, subject to stockholder approval, the
Company's 1997 Employee Stock Purchase Plan (the "Purchase Plan") covering
50,000 shares of the Company's Common Stock (subject to adjustment for any
dividend, stock split or other similar change in the Company's capitalization).
 
GENERAL
 
     The Purchase Plan consists of four semi-annual offerings of 12,500 shares
of Common Stock each. The offering periods shall be June 1 to the next
succeeding November 30, and December 1 to the next succeeding May 31, beginning
June 1, 1997. The number of shares available for any subsequent offering may be
increased
 
                                       13
<PAGE>   16
 
by the shares, if any, which were made available but not purchased during prior
offerings under the Purchase Plan.
 
     During each offering, the maximum number of shares which may be purchased
by an employee is determined on the first day of the offering period under a
formula whereby 85% of the market value of a share of Common Stock on the first
day of the offering period is divided into an amount equal to 6% of the
employee's annualized regular salary. An employee may elect to have up to a
maximum of 10% deducted from his or her regular salary for this purpose. The
price at which the employee's option is exercised is the lower of (a) 85% of the
closing price of the Common Stock as quoted on the Nasdaq Stock Market on the
day that the offering commences, or (b) 85% of the closing price of the Common
Stock as quoted on the Nasdaq Stock Market on the day that the offering
terminates.
 
ELIGIBILITY
 
     With certain limited exceptions in the case of employees already holding a
significant amount of Common Stock, each employee of the Company as of the date
an offering commences and who ordinarily works 20 or more hours per week and
more than five months per year is eligible to participate in the Purchase Plan.
As of March 14, 1997, approximately 59 employees were eligible to participate in
the Purchase Plan.
 
AMENDMENTS; ADMINISTRATION
 
     The Purchase Plan is administered by the Compensation Committee of the
Board of Directors which is authorized to make rules and regulations for the
administration and interpretation of the Purchase Plan. The Compensation
Committee may amend the Purchase Plan at any time. However, no amendment shall
be made without prior approval of the stockholders of the Company if such
amendment would (a) materially increase the benefits accruing to participants
under such Plan, (b) materially increase the number of shares which may be
issued under such Plan, or (c) materially modify the requirements as to
eligibility for participants under such Plan.
 
     Because option grants under the Purchase Plan will be at the election of
each officer or employee, the benefits to be received by any particular current
executive officer, by all current executive officers as a group, or by
non-executive officer employees as a group cannot be determined by the Company
at this time. Directors who are neither officers nor employees of the Company
are not eligible to participate in the Purchase Plan. During 1996, all current
executive officers purchased 1,682 shares of Common Stock, at a weighted average
price of $2.866 per share (representing 85% of the fair market value), under the
Company's 1995 Employee Stock Purchase Plan (the "1995 Purchase Plan"). During
1996, all employees, excluding all current executive officers, purchased 12,812
shares of Common Stock, at a weighted average price of $3.272 per share
(representing 85% of the fair market value on the first day or last day of the
offering, whichever is lowest), under the 1995 Purchase Plan. During 1996, no
current director of the Company purchased shares of Common Stock under the 1995
Purchase Plan.
 
FEDERAL TAX CONSEQUENCES
 
     The Purchase Plan is intended to qualify as an "employee stock purchase
plan" as defined in Section 423 of the Code, which provides that the employee
does not have to pay any federal income tax when such employee joins the
Purchase Plan, or when an offering ends and such employee receive shares of the
Company's Common Stock. The employee is, however, required to pay federal income
tax on the difference, if any, between the price at which he sells the shares
and the price he paid for them.
 
                                       14
<PAGE>   17
 
     If the employee has owned the shares for more than one year and disposes of
them at least two years after the date an offering commenced, he will be taxed
as described below. If the market price of the shares on the date they are sold
is less than the price paid for shares under the Purchase Plan, the employee
will incur a long-term capital loss in the amount equal to the price paid over
the sale price. If the sale price is higher than the price paid under the
Purchase Plan, such employee will have to recognize ordinary income in an amount
equal to the lesser of (i) the market price of the shares on the date the
offering commenced over the price paid; or (ii) the excess of the sale price
over the price paid. Any further gain is treated as long-term capital gain.
Except as set forth below, the Company will generally not be entitled to a tax
deduction upon the purchase or sale of shares under the Purchase Plan. If the
employee sells the shares before he has owned them for more than one year or
before the expiration of a two-year period commencing on the date the offering
period commenced, the employee will have to recognize ordinary income in the
amount of the difference between the option price and the market price of the
shares on the date of purchase and the Company will receive an expense deduction
for the same amount. The employee will recognize a capital gain or loss for the
difference between the sale price and the market price on the date of purchase.
The gain or loss will be long-term if the employee owned the shares for more
than one year.
 
BOARD RECOMMENDATION
 
     THE BOARD OF DIRECTORS BELIEVES THE PURCHASE PLAN IS IN THE BEST INTERESTS
OF THE COMPANY AND ITS STOCKHOLDERS AND THEREFORE RECOMMENDS A VOTE "FOR" THIS
PROPOSAL.
 
                     APPROVAL OF 1997 STOCK INCENTIVE PLAN
 
     On March 28, 1997, the Board of Directors of the Company adopted, subject
to stockholder approval, the 1997 Stock Incentive Plan (the "1997 Plan"). Up to
600,000 shares of Common Stock (subject to adjustment in the event of stock
splits and other similar events) may be issued pursuant to awards granted under
the 1997 Plan.
 
     The 1997 Plan is intended to replace the Company's 1994 Stock Option Plan
(the "1994 Plan"). As of March 14, 1997, options to purchase 914,500 shares of
Common Stock were outstanding under the 1994 Plan and an additional 85,500
shares were reserved for future option grants. All outstanding options under the
1994 Plan will remain in effect, but no additional option grants will be made
under the 1994 Plan.
 
     The Board of Directors believes that the continued growth and profitability
of the Company depends, in large part, upon the ability of the Company to
maintain a competitive position in attracting, retaining and motivating key
personnel.
 
DESCRIPTION OF AWARDS
 
     The 1997 Plan provides for the grant of incentive stock options intended to
qualify under Section 422 of the Code, nonstatutory stock options, restricted
stock awards and other stock-based awards, including the grant of shares based
upon certain conditions, the grant of securities convertible into Common Stock
and the grant of stock appreciation rights (collectively "Awards").
 
     Incentive Stock Options and Nonstatutory Stock Options.  Optionees receive
the right to purchase a specified number of shares of Common Stock at some time
in the future at a specified option price and subject to such other terms and
conditions as are specified in connection with the option grant. Options may be
granted at an exercise price which may be less than, equal to or greater than
the fair market value of the
 
                                       15
<PAGE>   18
 
Common Stock on the date of grant. Under present law, however, incentive stock
options and options intended to qualify as performance-based compensation under
Section 162(m) of the Code may not be granted at an exercise price less than the
fair market value of the Common Stock on the date of grant (or less than 110% of
the fair market value in the case of incentive stock options granted to
optionees holding 10% or more of the voting power of the Company). Options may
not be granted for a term in excess of ten years. The 1997 Plan permits the
Board to determine the manner of payment of the exercise price of options,
including through payment by cash, check or in connection with a "cashless
exercise" through a broker, by surrender to the Company of shares of Common
Stock, by delivery to the Company of a promissory note, or by any other lawful
means.
 
     Restricted Stock Awards.  Restricted stock Awards entitle recipients to
acquire shares of Common Stock, subject to the right of the Company to
repurchase all or part of such shares from the recipient in the event that the
conditions specified in the applicable Award are not satisfied prior to the end
of the applicable restriction period established for such Award.
 
     Other Stock-Based Awards.  Under the 1997 Plan, the Board has the right to
grant other Awards based upon the Common Stock having such terms and conditions
as the Board may determine, including the grant of shares based upon certain
conditions, the grant of securities convertible into Common Stock and the grant
of stock appreciation rights.
 
ELIGIBILITY TO RECEIVE AWARDS
 
     Officers, employees, directors, consultants and advisors of the Company and
its subsidiaries are eligible to be granted Awards under the 1997 Plan. Under
present law, however, incentive stock options may only be granted to employees.
The maximum aggregate number of shares with respect to which an Award may be
granted to any participant under the 1997 Plan may not exceed 300,000 shares
during the term of the Plan.
 
     As of March 14, 1997, approximately 66 persons were eligible to receive
Awards under the 1997 Plan, including the Company's five executive officers and
seven non-employee directors. The granting of Awards under the 1997 Plan is
discretionary, and the Company cannot now determine the number or type of Awards
to be granted in the future to any particular person or group.
 
     On March 14, 1997, the last reported sale price of the Company Common Stock
on the Nasdaq National Market was $3.50.
 
ADMINISTRATION
 
     The 1997 Plan is administered by the Board of Directors. The Board has the
authority to adopt, amend and repeal the administrative rules, guidelines and
practices relating to the 1997 Plan and to interpret the provisions of the 1997
Plan. Pursuant to the terms of the 1997 Plan, the Board of Directors may
delegate authority under the 1997 Plan to one or more committees of the Board,
and subject to certain limitations, to one or more executive officers of the
Company. The Board has authorized the Compensation Committee to administer
certain aspects of the 1997 Plan, including the granting of options to executive
officers. Subject to any applicable limitations contained in the 1997 Plan, the
Board of Directors, the Compensation Committee, or any other committee or
executive officer to whom the Board delegates authority, as the case may be,
selects the recipients of Awards and determines (i) the number of shares of
Common Stock covered by options and the dates upon which such options become
exercisable, (ii) the exercise price of options, (iii) the duration of options,
and (iv) the number of shares of Common Stock subject to any restricted stock or
other stock-based
 
                                       16
<PAGE>   19
 
Awards and the terms and conditions of such Awards, including conditions for
repurchase, issue price and repurchase price.
 
     The Board of Directors is required to make appropriate adjustments in
connection with the 1997 Plan and any outstanding Awards to reflect stock
dividends, stock splits and certain other events. In the event of a merger,
liquidation or other Acquisition Event (as defined in the 1997 Plan), the Board
of Directors is authorized to provide for outstanding Awards to be assumed or
substituted for, to accelerate the Awards to make them fully exercisable prior
to consummation of the Acquisition Event or to provide for a cash out of the
value of any outstanding options, provided, however, that any outstanding Awards
held by employees of the Company shall become immediately fully exercisable. If
any Award expires or is terminated, surrendered, canceled or forfeited, the
unused shares of Common Stock covered by such Award will again be available for
grant under the 1997 Plan.
 
AMENDMENT OR TERMINATION
 
     No Award may be made under the 1997 Plan after March 28, 2007, but Awards
previously granted may extend beyond that date. The Board of Directors may at
any time amend, suspend or terminate the 1997 Plan, except that no outstanding
Award designated as subject to Section 162(m) of the Code by the Board of
Directors after the date of such amendment shall become exercisable, realizable
or vested (to the extent such amendment was required to grant such Award) unless
and until such amendment shall have been approved by the Company's stockholders.
 
FEDERAL INCOME TAX CONSEQUENCES
 
     The following is a summary of the United States federal income tax
consequences that generally will arise with respect to Awards granted under the
1997 Plan and with respect to the sale of Common Stock acquired under the 1997
Plan.
 
     Incentive Stock Options.  In general, a participant will not recognize
taxable income upon the grant or exercise of an incentive stock option. Instead,
a participant will recognize taxable income with respect to an incentive stock
option only upon the sale of Common Stock acquired through the exercise of the
option ("ISO Stock"). The exercise of an incentive stock option may, however,
subject the participant to the alternative minimum tax.
 
     Generally, the tax consequences of selling ISO Stock will vary with the
length of time that the participant has owned the ISO Stock at the time it is
sold. If the participant sells ISO Stock after having owned it for at least two
years from the date the option was granted (the "Grant Date") and one year from
the date the option was exercised (the "Exercise Date"), then the participant
will recognize long-term capital gain in an amount equal to the excess of the
sale price of the ISO Stock over the exercise price.
 
     If the participant sells ISO Stock for more than the exercise price prior
to having owned it for at least two years from the Grant Date and one year from
the Exercise Date (a "Disqualifying Disposition"), then all or a portion of the
gain recognized by the participant will be ordinary compensation income and the
remaining gain, if any, will be a capital gain. This capital gain will be a
long-term capital gain if the participant has held the ISO Stock for more than
one year prior to the date of sale.
 
     If a participant sells ISO Stock for less than the exercise price, then the
participant will recognize capital loss equal to the excess of the exercise
price over the sale price of the ISO Stock. This capital loss will be a
long-term capital loss if the participant has held the ISO Stock for more than
one year prior to the date of sale.
 
                                       17
<PAGE>   20
 
     Nonstatutory Stock Options.  As in the case of an incentive stock option, a
participant will not recognize taxable income upon the grant of a nonstatutory
stock option. Unlike the case of an incentive stock option, however, a
participant who exercises a nonstatutory stock option generally will
recognize ordinary compensation income in an amount equal to the excess of the
fair market value of the Common Stock acquired through the exercise of the
option ("NSO Stock") on the Exercise Date over the exercise price.
 
     With respect to any NSO Stock, a participant will have a tax basis equal to
the exercise price plus any income recognized upon the exercise of the option.
Upon selling NSO Stock, a participant generally will recognize capital gain or
loss in an amount equal to the excess of the sale price of the NSO Stock over
the participant's tax basis in the NSO Stock. This capital gain or loss will be
a long-term gain or loss if the participant has held the NSO stock for more than
one year prior to the date of the sale.
 
     Restricted Stock Awards.  A participant will not recognize taxable income
upon the grant of a restricted stock Award, unless the participant makes an
election under Section 83(b) of the Code (a "Section 83(b) Election"). If the
participant makes a Section 83(b) Election within 30 days of the date of the
grant, then the participant will recognize ordinary income, for the year in
which the Award is granted, in an amount equal to the difference between the
fair market value of the Common Stock at the time the Award is granted and the
purchase price paid for the Common Stock. If a Section 83(b) Election is not
made, the participant will recognize ordinary income, at the time that the
forfeiture provisions or restrictions on transfer lapse, in an amount equal to
the difference between the fair market value of the Common Stock at the time of
such lapse and the original purchase price paid for the Common Stock. The
participant will have a basis in the Common Stock acquired equal to the sum of
the price paid and the amount of ordinary compensation income recognized.
 
     Upon the disposition of the Common Stock acquired pursuant to a restricted
stock Award, the participant will recognize a capital gain or loss equal to the
difference between the sale price of the Common Stock and the participant's
basis in the Common Stock. The gain or loss will be a long-term gain or loss if
the shares are held for more than one year. For this purpose, the holding period
shall begin just after the date on which the forfeiture provisions or
restrictions lapse if a Section 83(b) Election is not made, or just after the
Award is granted if a Section 83(b) Election is made.
 
     Other Stock-Based Awards.  The tax consequences associated with any other
stock-based Award granted under the 1997 Plan will vary depending on the
specific terms of such Award, including, whether or not the Award has a readily
ascertainable fair market value, whether or not the Award is subject to
forfeiture provisions or restrictions on transfer, the nature of the property to
be received by the participant under the Award, the participant's holding period
and tax basis for the Award or underlying Common Stock.
 
     Tax Consequences to the Company.  The grant of an Award under the 1997 Plan
will have no tax consequences to the Company. Moreover, in general, neither the
exercise of an incentive stock option nor the sale of any Common Stock acquired
under the 1997 Plan will have any tax consequences to the Company. The Company
generally will be entitled to a business-expense deduction, however, with
respect to any ordinary compensation income recognized by a participant under
the 1997 Plan, including as a result of the exercise of a nonstatutory stock
option, a Disqualifying Disposition or a Section 83(b) Election. Any such
deduction will be subject to the limitations of Section 162(m) of the Code. The
Company will have a withholding obligation with respect to any ordinary
compensation income recognized by participants with respect to the exercise of a
nonstatutory option or Restricted Stock Award under the 1997 Plan who are
employees or otherwise subject to withholding.
 
                                       18
<PAGE>   21
 
     Board Recommendation
 
     THE BOARD OF DIRECTORS BELIEVES THE 1997 PLAN IS IN THE BEST INTERESTS OF
THE COMPANY AND ITS STOCKHOLDERS AND THEREFORE RECOMMENDS A VOTE "FOR" THIS
PROPOSAL.
 
                            INDEPENDENT ACCOUNTANTS
 
     The Board of Directors, on the recommendation of its Audit Committee, has
selected the firm of Arthur Andersen LLP as the Company's independent
accountants for the current year. Arthur Andersen LLP has served as the
Company's independent accountants since January 1, 1996. Representatives of
Arthur Andersen LLP are expected to be present at the Annual Meeting. They will
have the opportunity to make a statement if they desire to do so and will also
be available to respond to appropriate questions from stockholders.
 
     On January 26, 1996, the Company, upon the recommendation of its Audit
Committee and the approval of its Board of Directors, determined that it would
dismiss Coopers & Lybrand L.L.P. as its principal accountant and retain Arthur
Andersen LLP as its principal accountant, effective upon completion of the audit
by Coopers & Lybrand L.L.P. of the Company's financial statements for the fiscal
year ended December 31, 1995 (the "1995 Audit"). The determination to dismiss
Coopers & Lybrand L.L.P. was made because Coopers & Lybrand L.L.P. agreed to
serve as independent accountants for PerSeptive BioSystems, Inc., a competitor
of the Company.
 
     The Company had no disagreement with Coopers & Lybrand L.L.P. on any matter
of accounting principles or practices, financial statement disclosure, or
auditing scope or procedure in connection with the audits of the Company's
financial statements for the fiscal years ended December 31, 1995 and December
31, 1994. Coopers & Lybrand L.L.P.'s reports on the Company's financial
statements for the fiscal years ended December 31, 1995 and December 31, 1994
did not contain any adverse opinion or a disclaimer of an opinion nor were they
qualified as to uncertainty, audit scope, or accounting principles.
 
                                 OTHER MATTERS
 
     The Board of Directors does not know of any other matters which may come
before the meeting. However, if any other matters are properly presented to the
meeting, it is the intention of the persons named in the accompanying proxy to
vote, or otherwise act, in accordance with their judgment on such matters.
 
     All costs of solicitation of proxies will be borne by the Company. In
addition to solicitations by mail, the Company's directors, officers and regular
employees, without additional remuneration, may solicit proxies by telephone,
telegraph and personal interviews. Brokers, custodians and fiduciaries will be
requested to forward proxy soliciting material to the owners of stock held in
their names, and the Company will reimburse them for their reasonable
out-of-pocket expenses incurred in connection with the distribution of proxy
materials.
 
                                       19
<PAGE>   22
 
DEADLINE FOR SUBMISSION OF STOCKHOLDER PROPOSALS FOR THE 1998 ANNUAL MEETING
 
     Proposals of stockholders intended to be presented at the 1998 Annual
Meeting of Stockholders must be received by the Company at its principal office
in Marlborough, Massachusetts not later than December 12, 1997 for inclusion in
the proxy statement for that meeting.
 
                                          By Order of the Board of Directors,
 
                                          ROBERT F. SCUMACI, Secretary
 
April 11, 1997
 
     THE BOARD OF DIRECTORS ENCOURAGES STOCKHOLDERS TO ATTEND THE MEETING.
WHETHER OR NOT YOU PLAN TO ATTEND, YOU ARE URGED TO COMPLETE, DATE, SIGN AND
RETURN THE ENCLOSED PROXY IN THE ACCOMPANYING ENVELOPE. A PROMPT RESPONSE WILL
GREATLY FACILITATE ARRANGEMENTS FOR THE MEETING AND YOUR COOPERATION WILL BE
APPRECIATED. STOCKHOLDERS WHO ATTEND THIS MEETING MAY VOTE THEIR STOCK
PERSONALLY EVEN THOUGH THEY HAVE SENT IN THEIR PROXIES.
 
                                       20
<PAGE>   23



[CAPTION]
                Appendix A -- 1997 Employee Stock Purchase Plan

























<PAGE>   24

                                  BIOSEPRA INC.

                        1997 EMPLOYEE STOCK PURCHASE PLAN


     The purpose of this Plan is to provide eligible employees of BioSepra Inc.
(the "Company") and certain of its subsidiaries with opportunities to purchase
shares of the Company's common stock, $.01 par value (the "Common Stock"). Fifty
Thousand (50,000) shares of Common Stock in the aggregate have been approved for
this purpose.

     1. ADMINISTRATION. The Plan will be administered by the Company's Board of
Directors (the "Board") or by a Committee appointed by the Board (the
"Committee"). The Board or the Committee has authority to make rules and
regulations for the administration of the Plan and its interpretation and
decisions with regard thereto shall be final and conclusive.

     2. ELIGIBILITY. Participation in the Plan will neither be permitted nor
denied contrary to the requirements of Section 423 of the Internal Revenue Code
of 1986, as amended (the "Code"), and regulations promulgated thereunder. All
employees of the Company, including Directors who are employees, and all
employees of any subsidiary of the Company (as defined in Section 424(f) of the
Code) designated by the Board or the Committee from time to time (a "Designated
Subsidiary"), are eligible to participate in any one or more of the offerings of
Options (as defined in Section 9) to purchase Common Stock under the Plan
provided that:

          (a) they are regularly employed by the Company or a Designated
     Subsidiary for more than 20 hours a week and for more than five months in a
     calendar year; and

          (b) they are employees of the Company or a Designated Subsidiary on
     the first day of the applicable Plan Period (as defined below).

     No employee may be granted an option hereunder if such employee,
immediately after the option is granted, owns 5% or more of the total combined
voting power or value of the stock of the Company or any subsidiary. For
purposes of the preceding sentence, the attribution rules of Section 424(d) of
the Code shall apply in determining the stock ownership of an employee, and all
stock which the employee has a contractual right to purchase shall be treated as
stock owned by the employee.

     3. OFFERINGS. The Company will make one or more offerings ("Offerings") to
employees to purchase stock under this Plan. Offerings will begin each June 1
and


<PAGE>   25



December 1, or the first business day thereafter (the "Offering Commencement
Dates"). Each Offering Commencement Date will begin a six month period (a "Plan
Period") during which payroll deductions will be made and held for the purchase
of Common Stock at the end of the Plan Period. The Board or the Committee may,
at its discretion, choose a different Plan Period of twelve (12) months or less
for subsequent Offerings. Offerings under this Plan shall be as follows:

          June 1, 1996 to November 30, 1996 
          December 1, 1996 to May 31, 1997 
          June 1, 1997 to November 30, 1997 
          December 1, 1997 to May 31, 1998.

     4. PARTICIPATION. An employee eligible on the Offering Commencement Date of
any Offering may participate in such Offering by completing and forwarding a
payroll deduction authorization form to the employee's appropriate payroll
office at least 30 days prior to the applicable Offering Commencement Date. The
form will authorize a regular payroll deduction from the Compensation received
by the employee during the Plan Period. Unless an employee files a new form or
withdraws from the Plan, his deductions and purchases will continue at the same
rate for future Offerings under the Plan as long as the Plan remains in effect.
The term "Compensation" means the amount of money reportable on the employee's
Federal Income Tax Withholding Statement, excluding overtime, incentive or bonus
awards, allowances and reimbursements for expenses such as relocation allowances
for travel expenses, income or gains on the exercise of Company stock options
and similar items, whether or not shown on the employee's Federal Income Tax
Withholding Statement.

     5. DEDUCTIONS. The Company will maintain payroll deduction accounts for all
participating employees. Payroll deductions may be at the rate of 1%, 2%, 3%,
4%, 5%, 6%, 7%, 8%, 9% or 10% of Compensation with any change in compensation
during the Plan Period to result in an automatic corresponding change in the
dollar amount withheld.

     No employee may be granted an Option (as defined in Section 9) which
permits his rights to purchase Common Stock under this Plan and any other stock
purchase plan of the Company and its subsidiaries, to accrue at a rate which
exceeds $25,000 of the fair market value of such Common Stock (determined at the
Offering Commencement Date of the Plan Period) for each calendar year in which
the Option is outstanding at any time.

     6. DEDUCTION CHANGES. An employee may decrease or discontinue his payroll
deduction once during any Plan Period, by filing a new payroll deduction
authorization form. However, an employee may not increase his payroll deduction
during a Plan Period. If an employee elects to discontinue his payroll
deductions

                                       -2-

<PAGE>   26



during a Plan Period, but does not elect to withdraw his funds pursuant to
Section 8 hereof, funds deducted prior to his election to discontinue will be
applied to the purchase of Common Stock on the Exercise Date (as defined below).

     7. INTEREST. Interest will not be paid on any employee accounts, except to
the extent that the Board or the Committee, in its sole discretion, elects to
credit employee accounts with interest at such per annum rate as it may from
time to time determine.

     8. WITHDRAWAL OF FUNDS. An employee may at any time prior to the close of
business on the last business day in a Plan Period and for any reason
permanently draw out the balance accumulated in the employee's account and
thereby withdraw from participation in an Offering. Partial withdrawals are not
permitted. The employee may not begin participation again during the remainder
of the Plan Period. The employee may participate in any subsequent Offering in
accordance with terms and conditions established by the Board or the Committee.

     9. PURCHASE OF SHARES. On the Offering Commencement Date of each Plan
Period, the Company will grant to each eligible employee who is then a
participant in the Plan an option ("Option") to purchase on the last business
day of such Plan Period (the "Exercise Date"), at the Option Price hereinafter
provided for, such number of whole shares of Common Stock of the Company
reserved for the purposes of the Plan as does not exceed the number of shares
determined by dividing 6% of such employee's annualized Compensation for the
immediately prior six-month period by the price determined in accordance with
the formula set forth in the following paragraph but using the closing price on
the Offering Commencement Date of such Plan Period.

     The purchase price for each share purchased will be 85% of the closing
price of the Common Stock on (i) the first business day of such Plan Period or
(ii) the Exercise Date, whichever closing price shall be less. Such closing
price shall be (a) the closing price on any national securities exchange on
which the Common Stock is listed, (b) the closing price of the Common Stock on
the Nasdaq National Market or (c) the average of the closing bid and asked
prices in the over-the-counter-market, whichever is applicable, as published in
THE WALL STREET JOURNAL. If no sales of Common Stock were made on such a day,
the price of the Common Stock for purposes of clauses (a) and (b) above shall be
the reported price for the next preceding day on which sales were made.

     Each employee who continues to be a participant in the Plan on the Exercise
Date shall be deemed to have exercised his Option at the Option Price on such
date and shall be deemed to have purchased from the Company the number of full
shares of Common Stock reserved for the purpose of the Plan that his accumulated
payroll

                                       -3-

<PAGE>   27



deductions on such date will pay for pursuant to the formula set forth above
(but not in excess of the maximum number determined in the manner set forth
above).

     Any balance remaining in an employee's payroll deduction account at the end
of a Plan Period will be automatically refunded to the employee, except that any
balance which is less than the purchase price of one share of Common Stock will
be carried forward into the employee's payroll deduction account for the
following Offering, unless the employee elects not to participate in the
following Offering under the Plan, in which case the balance in the employee's
account shall be refunded.

     10. ISSUANCE OF CERTIFICATES. Certificates representing shares of Common
Stock purchased under the Plan may be issued only in the name of the employee,
in the name of the employee and another person of legal age as joint tenants
with rights of survivorship, or (in the Company's sole discretion) in the street
name of a brokerage firm, bank or other nominee holder designated by the
employee.

     11. RIGHTS ON RETIREMENT DEATH OR TERMINATION OF EMPLOYMENT. In the event
of a participating employee's termination of employment prior to the last
business day of a Plan Period, no payroll deduction shall be taken from any pay
due and owing to an employee and the balance in the employee's account shall be
paid to the employee or, in the event of the employee's death, (a) to a
beneficiary previously designated in a revocable notice signed by the employee
(with any spousal consent required under state law) or (b) in the absence of
such a designated beneficiary, to the executor or administrator of the
employee's estate or (c) if no such executor or administrator has been appointed
to the knowledge of the Company, to such other person(s) as the Company may, in
its discretion, designate. If, prior to the last business day of the Plan
Period, the Designated Subsidiary by which an employee is employed shall cease
to be a subsidiary of the Company, or if the employee is transferred to a
subsidiary of the Company that is not a Designated Subsidiary, the employee
shall be deemed to have terminated employment for the purposes of this Plan.

     12. OPTIONEES NOT STOCKHOLDERS. Neither the granting of an Option to an
employee nor the deductions from his pay shall constitute such employee a
stockholder of the shares of Common Stock covered by an Option under this Plan
until such shares have been purchased by and issued to him.

     13. RIGHTS NOT TRANSFERABLE. Except as the Board of Directors may otherwise
determine or provide, rights under this Plan shall not be sold, assigned,
transferred, pledged or otherwise encumbered by an employee, either voluntarily
or by operation of law, except by will or the laws of descent and distribution,
and are exercisable during the employee's lifetime only by the employee.


                                       -4-

<PAGE>   28



     14. APPLICATION OF FUNDS. All funds received or held by the Company under
this Plan may be combined with other corporate funds and may be used for any
corporate purpose.

     15. ADJUSTMENT IN CASE OF CHANGES AFFECTING COMMON STOCK. In the event of a
subdivision of outstanding shares of Common Stock, or the payment of a dividend
in Common Stock, the number of shares approved for this Plan, and the share
limitation set forth in Section 9, shall be increased proportionately, and such
other adjustment shall be made as may be deemed equitable by the Board or the
Committee. In the event of any other change affecting the Common Stock such
adjustment shall be made as may be deemed equitable by the Board or the
Committee to give proper effect to such event.

     16. MERGER. If the Company shall at any time merge or consolidate with
another corporation and the holders of the capital stock of the Company
immediately prior to such merger or consolidation continue to hold at least 80%
by voting power of the capital stock of the surviving corporation ("Continuity
of Control"), the holder of each Option then outstanding will thereafter be
entitled to receive at the next Exercise Date upon the exercise of such Option
for each share as to which such Option shall be exercised the securities or
property which a holder of one share of the Common Stock was entitled to upon
and at the time of such merger, and the Committee shall take such steps in
connection with such merger as the Committee shall deem necessary to assure that
the provisions of Paragraph 15 shall thereafter be applicable, as nearly as
reasonably may be, in relation to the said securities or property as to which
such holder of such Option might thereafter be entitled to receive thereunder.

     In the event of a merger or consolidation of the Company with or into
another corporation which does not involve Continuity of Control, or of a sale
of all or substantially all of the assets of the Company while unexercised
Options remain outstanding under the Plan, (a) subject to the provisions of
clauses (b) and (c), after the effective date of such transaction, each holder
of an outstanding Option shall be entitled, upon exercise of such Option, to
receive in lieu of shares of Common Stock, shares of such stock or other
securities as the holders of shares of Common Stock received pursuant to the
terms of such transaction; or (b) all outstanding Options may be cancelled by
the Board or the Committee as of a date prior to the effective date of any such
transaction and all payroll deductions shall be paid out to the participating
employees; or (c) all outstanding Options may be cancelled by the Board or the
Committee as of the effective date of any such transaction, provided that notice
of such cancellation shall be given to each holder of an Option, and each holder
of an Option shall have the right to exercise such Option in full based on
payroll deductions then credited to his account as of a date determined by the
Board or the Committee, which date shall not be less than ten (10) days
preceding the effective date of such transaction.

                                       -5-

<PAGE>   29



     17. AMENDMENT OF THE PLAN. The Board may at any time, and from time to
time, amend this Plan in any respect, except that (a) if the approval of any
such amendment by the shareholders of the Company is required by Section 423 of
the Code or by Rule 16b-3 under the Exchange Act, such amendment shall not be
effected without such approval, and (b) in no event may any amendment be made
which would cause the Plan to fail to comply with Section 16 of the Exchange Act
and the rules promulgated thereunder, as in effect from time to time, or Section
423 of the Code.

     18. INSUFFICIENT SHARES. In the event that the total number of shares of
Common Stock specified in elections to be purchased under any Offering plus the
number of shares purchased under previous Offerings under this Plan exceeds the
maximum number of shares issuable under this Plan, the Board or the Committee
will allot the shares then available on a pro rata basis.

     19. TERMINATION OF THE PLAN. This Plan may be terminated at any time by the
Board. Upon termination of this Plan all amounts in the accounts of
participating employees shall be promptly refunded.

     20. GOVERNMENTAL REGULATIONS. The Company's obligation to sell and deliver
Common Stock under this Plan is subject to listing on a national stock exchange
or quotation on the Nasdaq National Market and the approval of all governmental
authorities required in connection with the authorization, issuance or sale of
such stock.

     The Plan shall be governed by Delaware law except to the extent that such
law is preempted by federal law.

     The Plan is intended to comply with the provisions of Rule 16b-3
promulgated under the Securities Exchange Act of 1934. Any provision
inconsistent with such Rule shall to that extent be inoperative and shall not
affect the validity of the Plan.

     21. ISSUANCE OF SHARES. Shares may be issued upon exercise of an Option
from authorized but unissued Common Stock, from shares held in the treasury of
the Company, or from any other proper source.

     22. NOTIFICATION UPON SALE OF SHARES. Each employee agrees, by entering the
Plan, to promptly give the Company notice of any disposition of shares purchased
under the Plan where such disposition occurs within two years after the date of
grant of the Option pursuant to which such shares were purchased.

     23. EFFECTIVE DATE AND APPROVAL OF SHAREHOLDERS. The Plan shall take effect
upon the closing of the Company's initial public offering of Common Stock
pursuant to an effective registration statement under the Securities Act of
1933, as amended,

                                       -6-

<PAGE>   30



subject to approval by the shareholders of the Company as required by Rule 16b-3
under the Exchange Act or by Section 423 of the Code, which approval must occur
within twelve months of the adoption of the Plan by the Board.

                                           Adopted by the Board of Directors on
                                           March 28, 1997


                                           To be submitted for Approval by the
                                           Stockholders on May 14, 1997





                                       -7-

<PAGE>   31

                    Appendix B -- 1997 Stock Incentive Plan




























<PAGE>   32

*
                                  BIOSEPRA INC.

                            1997 STOCK INCENTIVE PLAN
                            -------------------------


1.   Purpose
     -------

     The purpose of this 1997 Stock Incentive Plan (the "Plan") of BioSepra
Inc., a Delaware corporation (the "Company"), is to advance the interests of the
Company's stockholders by enhancing the Company's ability to attract, retain and
motivate persons who make (or are expected to make) important contributions to
the Company by providing such persons with equity ownership opportunities and
performance-based incentives and thereby better aligning the interests of such
persons with those of the Company's stockholders. Except where the context
otherwise requires, the term "Company" shall include any present or future
subsidiary corporations of BioSepra Inc. as defined in Section 424(f) of the
Internal Revenue Code of 1986, as amended, and any regulations promulgated
thereunder (the "Code").

2.   Eligibility
     -----------

     All of the Company's employees, officers, directors, consultants and
advisors are eligible to be granted options, restricted stock, or other
stock-based awards (each, an "Award") under the Plan. Any person who has been
granted an Award under the Plan shall be deemed a "Participant".

3.   Administration, Delegation
     --------------------------

     (a) ADMINISTRATION BY BOARD OF DIRECTORS. The Plan will be administered by
the Board of Directors of the Company (the "Board"). The Board shall have
authority to grant Awards and to adopt, amend and repeal such administrative
rules, guidelines and practices relating to the Plan as it shall deem advisable.
The Board may correct any defect, supply any omission or reconcile any
inconsistency in the Plan or any Award in the manner and to the extent it shall
deem expedient to carry the Plan into effect and it shall be the sole and final
judge of such expediency. All decisions by the Board shall be made in the
Board's sole discretion and shall be final and binding on all persons having or
claiming any interest in the Plan or in any Award. No director or person acting
pursuant to the authority delegated by the Board shall be liable for any action
or determination relating to or under the Plan made in good faith.

     (b) DELEGATION TO EXECUTIVE OFFICERS. To the extent permitted by applicable


<PAGE>   33



law, the Board may delegate to one or more executive officers of the Company the
power to make Awards and exercise such other powers under the Plan as the Board
may determine, provided that the Board shall fix the maximum number of shares
subject to Awards and the maximum number of shares for any one Participant to be
made by such executive officers.

     (c) APPOINTMENT OF COMMITTEES. To the extent permitted by applicable law,
the Board may delegate any or all of its powers under the Plan to one or more
committees or subcommittees of the Board (a "Committee"). During such periods
when the common stock, $.01 par value per share, of the Company (the "Common
Stock") is registered under the Securities Exchange Act of 1934 (the "Exchange
Act"), the Board shall appoint one such Committee of not less than two members,
each member of which shall be an "outside director" within the meaning of
Section 162(m) of the Code and a "non-employee director" as defined in Rule
16b-3 promulgated under the Exchange Act. All references in the Plan to the
"Board" shall mean the Board or a Committee of the Board or the executive
officer referred to in Section 3(b) to the extent that the Board's powers or
authority under the Plan have been delegated to such Committee or executive
officer.

4.   Stock Available for Awards
     --------------------------

     (a) NUMBER OF SHARES. Subject to adjustment under Section 4(c), Awards may
be made under the Plan for up to 600,000 shares of Common Stock. If any Award
expires or is terminated, surrendered or canceled without having been fully
exercised or is forfeited in whole or in part or results in any Common Stock not
being issued, the unused Common Stock covered by such Award shall again be
available for the grant of Awards under the Plan, subject, however, in the case
of Incentive Stock Options (as hereinafter defined), to any limitation required
under the Code. Shares issued under the Plan may consist in whole or in part of
authorized but unissued shares or treasury shares.

     (b) PER-PARTICIPANT LIMIT. Subject to adjustment under Section 4(c), for
Awards granted after the Common Stock is registered under the Exchange Act, the
maximum aggregate number of shares with respect to which an Award may be granted
to any Participant under the Plan shall be 300,000 during the term of the Plan.
The per-participant limit described in this Section 4(b) shall be construed and
applied consistently with Section 162(m) of the Code.



                                        2

<PAGE>   34





     (c) ADJUSTMENT TO COMMON STOCK. In the event of any stock split, stock
dividend, recapitalization, reorganization, merger, consolidation, combination,
exchange of shares, liquidation, spin-off or other similar change in
capitalization or event, or any distribution to holders of Common Stock other
than a normal cash dividend, (i) the number and class of securities available
under this Plan, (ii) the number and class of security and exercise price per
share subject to each outstanding Option, (iii) the repurchase price per
security subject to each outstanding Restricted Stock Award, and (iv) the terms
of each other outstanding stock-based Award shall be appropriately adjusted by
the Company (or substituted Awards may be made, if applicable) to the extent the
Board shall determine, in good faith, that such an adjustment (or substitution)
is necessary and appropriate. If this Section 4(c) applies and Section 8(e)(1)
also applies to any event, Section 8(e)(1) shall be applicable to such event,
and this Section 4(c) shall not be applicable.

5.   Stock Options
     -------------

     (a) GENERAL. The Board may grant options to purchase Common Stock (each, an
"Option") and determine the number of shares of Common Stock to be covered by
each Option, the exercise price of each Option and the conditions and
limitations applicable to the exercise of each Option, including conditions
relating to applicable federal or state securities laws, as it considers
necessary or advisable. An Option which is not intended to be an Incentive Stock
Option (as hereinafter defined) shall be designated a "Nonstatutory Stock
Option".

     (b) INCENTIVE STOCK OPTIONS. An Option that the Board intends to be an
"incentive stock option" as defined in Section 422 of the Code (an "Incentive
Stock Option") shall only be granted to employees of the Company and shall be
subject to and shall be construed consistently with the requirements of Section
422 of the Code. The Company shall have no liability to a Participant, or any
other party, if an Option (or any part thereof) which is intended to be an
Incentive Stock Option is not an Incentive Stock Option.

     (c) EXERCISE PRICE. The Board shall establish the exercise price at the
time each Option is granted and specify it in the applicable option agreement.

     (d) DURATION OF OPTIONS. Each Option shall be exercisable at such times and
subject to such terms and conditions as the Board may specify in the applicable
option agreement. No Option will be granted for a term in excess of 10 years.

     (e) EXERCISE OF OPTION. Options may be exercised only by delivery to the
Company of a written notice of exercise signed by the proper person together
with

                                        3

<PAGE>   35





payment in full as specified in Section 5(f) for the number of shares for which
the Option is exercised.

     (f) PAYMENT UPON EXERCISE. Common Stock purchased upon the exercise of an
Option granted under the Plan shall be paid for as follows:

         (1) in cash or by check, payable to the order of the Company;

         (2) except as the Board may otherwise provide in an Option Agreement,
(i) by delivery of an irrevocable and unconditional undertaking by a credit
worthy broker to deliver promptly to the Company sufficient funds to pay the
exercise price, or delivery by the Participant to the Company of a copy of
irrevocable and unconditional instructions to a credit worthy broker to deliver
promptly to the Company cash or a check sufficient to pay the exercise price or
(ii) by delivery of shares of Common Stock owned by the Participant valued at
their fair market value as determined by the Board in good faith ("Fair Market
Value"), which Common Stock was owned by the Participant at least six months
prior to such delivery.

         (3) to the extent permitted by the Board and explicitly provided in an
Option Agreement (i) by delivery of a promissory note of the Participant to the
Company on terms determined by the Board or (ii) by payment of such other lawful
consideration as the Board may determine; or

         (4) any combination of the above permitted forms of payment.

6.   Restricted Stock
     ----------------

     (a) GRANTS. The Board may grant Awards entitling recipients to acquire
shares of Common Stock, subject to the right of the Company to repurchase all or
part of such shares at their issue price or other stated or formula price (or to
require forfeiture of such shares if issued at no cost) from the recipient in
the event that conditions specified by the Board in the applicable Award are not
satisfied prior to the end of the applicable restriction period or periods
established by the Board for such Award (each, "Restricted Stock Award").

     (b) TERMS AND CONDITIONS. The Board shall determine the terms and
conditions of any such Restricted Stock Award, including the conditions for
repurchase (or forfeiture) and the issue price, if any. Any stock certificates
issued in respect of a Restricted Stock Award shall be registered in the name of
the Participant and, unless otherwise determined by the Board, deposited by the
Participant, together with a stock power endorsed in blank, with the Company (or
its designee). At the

                                        4

<PAGE>   36





expiration of the applicable restriction periods, the Company (or such designee)
shall deliver the certificates no longer subject to such restrictions to the
Participant or if the Participant has died, to the beneficiary designated, in a
manner determined by the Board, by a Participant to receive amounts due or
exercise rights of the Participant in the event of the Participant's death (the
"Designated Beneficiary"). In the absence of an effective designation by a
Participant, Designated Beneficiary shall mean the Participant's estate.

7.   Other Stock-Based Awards
     ------------------------

     The Board shall have the right to grant other Awards based upon the Common
Stock having such terms and conditions as the Board may determine, including the
grant of shares based upon certain conditions, the grant of securities
convertible into Common Stock and the grant of stock appreciation rights.

8.   General Provisions Applicable to Awards
     ---------------------------------------

     (a) TRANSFERABILITY OF AWARDS. Except as the Board may otherwise determine
or provide in an Award, Awards shall not be sold, assigned, transferred, pledged
or otherwise encumbered by the person to whom they are granted, either
voluntarily or by operation of law, except by will or the laws of descent and
distribution, and, during the life of the Participant, shall be exercisable only
by the Participant. References to a Participant, to the extent relevant in the
context, shall include references to authorized transferees.

     (b) DOCUMENTATION. Each Award under the Plan shall be evidenced by a
written instrument in such form as the Board shall determine. Each Award may
contain terms and conditions in addition to those set forth in the Plan.

     (c) BOARD DISCRETION. Except as otherwise provided by the Plan, each type
of Award may be made alone or in addition or in relation to any other type of
Award. The terms of each type of Award need not be identical, and the Board need
not treat Participants uniformly.

     (d) TERMINATION OF STATUS. The Board shall determine the effect on an Award
of the disability, death, retirement, authorized leave of absence or other
change in the employment or other status of a Participant and the extent to
which, and the period during which, the Participant, the Participant's legal
representative, conservator, guardian or Designated Beneficiary may exercise
rights under the Award.


                                        5

<PAGE>   37





     (e) Acquisition Events
         ------------------

         (1) CONSEQUENCES OF ACQUISITION EVENTS. Subject to Section 8(e)(2)
below, upon the occurrence of an Acquisition Event (as defined below), or the
execution by the Company of any agreement with respect to an Acquisition Event,
the Board shall take any one or more of the following actions with respect to
then outstanding Awards: (i) provide that outstanding Options shall be assumed,
or equivalent Options shall be substituted, by the acquiring or succeeding
corporation (or an affiliate thereof), provided that any such Options
substituted for Incentive Stock Options shall satisfy, in the determination of
the Board, the requirements of Section 424(a) of the Code; (ii) upon written
notice to the Participants, provide that all then unexercised Options will
become exercisable in full as of a specified date (the "Acceleration Date")
prior to the Acquisition Event and will terminate immediately prior to the
consummation of such Acquisition Event, except to the extent exercised by the
Participants between the Acceleration Date and the consummation of such
Acquisition Event; (iii) in the event of an Acquisition Event under the terms of
which holders of Common Stock will receive upon consummation thereof a cash
payment for each share of Common Stock surrendered pursuant to such Acquisition
Event (the "Acquisition Price"), provide that all outstanding Options shall
terminate upon consummation of such Acquisition Event and each Participant shall
receive, in exchange therefor, a cash payment equal to the amount (if any) by
which (A) the Acquisition Price multiplied by the number of shares of Common
Stock subject to such outstanding Options (whether or not then exercisable),
exceeds (B) the aggregate exercise price of such Options; (iv) provide that all
Restricted Stock Awards then outstanding shall become free of all restrictions
prior to the consummation of the Acquisition Event; and (v) provide that any
other stock-based Awards outstanding (A) shall become exercisable, realizable or
vested in full, or shall be free of all conditions or restrictions, as
applicable to each such Award, prior to the consummation of the Acquisition
Event, or (B), if applicable, shall be assumed, or equivalent Awards shall be
substituted, by the acquiring or succeeding corporation (or an affiliate
thereof).

     An "Acquisition Event" shall be deemed to have occurred only if any of the
following events occur: (a) the stockholders of the Company approve a merger or
consolidation which results in the voting securities of the Company outstanding
immediately prior thereto representing thereafter (either by remaining
outstanding or by being converted into voting securities of the surviving or
acquiring entity) less than 50% of the combined voting power of the voting
securities of the Company or such surviving or acquiring entity outstanding
immediately after such merger or consolidation; (b) any sale of all or
substantially all of the assets of the Company; (c) the complete liquidation of
the Company; or (d) the acquisition of "beneficial

                                        6

<PAGE>   38





ownership" (as defined in Rule 13d-3 under the Exchange Act) of securities of
the Company representing 50% or more of the combined voting power of the
Company's then outstanding securities (other than through a merger or
consolidation or an acquisition of securities directly from the Company) by any
"person", as such term is used in Sections 13(d) and 14(d) of the Exchange Act
other than the Company, Sepracor Inc. (or its successor), any trustee or other
fiduciary holding securities under an employee benefit plan of the Company or
any corporation owned directly or indirectly by the stockholders of the Company
in substantially the same proportion as their ownership of stock of the Company;
or (e) individuals who, on the date on which the Plan was adopted by the Board
of Directors, constituted the Board of Directors of the Company, together with
any new director whose election by the Board of Directors or nomination for
election by the Company's stockholders was approved by a vote of at least a
majority of the directors then still in office who were directors on the date on
which the Plan was adopted by the Board of Directors or whose election or
nomination was previously so approved, cease for any reason to constitute at
least a majority of the Board of Directors.

          (2) ACCELERATION UPON AN ACQUISITION EVENT. Except to the extent
otherwise provided in the instrument evidencing the Award or in any other
agreement between the Participant and the Company, upon the occurrence of an
Acquisition Event or with repsect to Options or any other similar Awards only,
upon the execution by the Company of any agreement with resepct to an
Acquisition Event, (i) the Board shall provide a written notice to the
Participants that are employees of the Company that all Options then outstanding
shall become immediately exercisable in full as of a specified date (the
"Acceleration Date") prior to the Acquisition Event and will terminate
immediately prior to the consummation of such Acquisition Event, except to the
extent exercised by the Participants between the Acceleration Date and the
consummation of such Acquisition Event; (ii) all Restricted Stock Awards then
outstanding and held by employees of the Company shall become immediately free
of all restrictions; (iii) all other stock-based Awards that are held by
employees of the Company shall become immediately exercisable, realizable or
vested in full, or shall be immediately free of all restrictions or conditions,
as the case may be.

          (3) ASSUMPTION OF OPTIONS UPON CERTAIN EVENTS. The Board may grant
Awards under the Plan in substitution for stock and stock-based awards held by
employees of another corporation who become employees of the Company as a result
of a merger or consolidation of the employing corporation with the Company or
the acquisition by the Company of property or stock of the employing
corporation. The substitute Awards shall be granted on such terms and conditions
as the Board considers appropriate in the circumstances.

                                        7

<PAGE>   39





     (f) WITHHOLDING. Each Participant shall pay to the Company, or make
provision satisfactory to the Board for payment of, any taxes required by law to
be withheld in connection with Awards to such Participant no later than the date
of the event creating the tax liability. The Board may allow Participants to
satisfy such tax obligations in whole or in part in shares of Common Stock,
including shares retained from the Award creating the tax obligation, valued at
their Fair Market Value. The Company may, to the extent permitted by law, deduct
any such tax obligations from any payment of any kind otherwise due to a
Participant.

     (g) AMENDMENT OF AWARD. The Board may amend, modify or terminate any
outstanding Award, including but not limited to, substituting therefor another
Award of the same or a different type, changing the date of exercise or
realization, and converting an Incentive Stock Option to a Nonstatutory Stock
Option, provided that the Participant's consent to such action shall be required
unless the Board determines that the action, taking into account any related
action, would not materially and adversely affect the Participant.

     (h) CONDITIONS ON DELIVERY OF STOCK. The Company will not be obligated to
deliver any shares of Common Stock pursuant to the Plan or to remove
restrictions from shares previously delivered under the Plan until (i) all
conditions of the Award have been met or removed to the satisfaction of the
Company, (ii) in the opinion of the Company's counsel, all other legal matters
in connection with the issuance and delivery of such shares have been satisfied,
including any applicable securities laws and any applicable stock exchange or
stock market rules and regulations, and (iii) the Participant has executed and
delivered to the Company such representations or agreements as the Company may
consider appropriate to satisfy the requirements of any applicable laws, rules
or regulations.

     (i) ACCELERATION. The Board may at any time provide that any Options shall
become immediately exercisable in full or in part, that any Restricted Stock
Awards shall be free of all restrictions or that any other stock-based Awards
may become exercisable in full or in part or free of some or all restrictions or
conditions, or otherwise realizable in full or in part, as the case may be.

9.   Miscellaneous
     -------------

     (a) NO RIGHT TO EMPLOYMENT OR OTHER STATUS. No person shall have any claim
or right to be granted an Award, and the grant of an Award shall not be
construed as giving a Participant the right to continued employment or any other
relationship with the Company. The Company expressly reserves the right at any

                                        8

<PAGE>   40




time to dismiss or otherwise terminate its relationship with a Participant free
from any liability or claim under the Plan, except as expressly provided in the
applicable Award.

     (b) NO RIGHTS AS STOCKHOLDER. Subject to the provisions of the applicable
Award, no Participant or Designated Beneficiary shall have any rights as a
stockholder with respect to any shares of Common Stock to be distributed with
respect to an Award until becoming the record holder of such shares.

     (c) EFFECTIVE DATE AND TERM OF PLAN. The Plan shall become effective on the
date on which it is adopted by the Board, but no Award granted to a Participant
designated as subject to Section 162(m) by the Board shall become exercisable,
vested or realizable, as applicable to such Award, unless and until the Plan has
been approved by the Company's stockholders. No Awards shall be granted under
the Plan after the completion of ten years from the earlier of (i) the date on
which the Plan was adopted by the Board or (ii) the date the Plan was approved
by the Company's stockholders, but Awards previously granted may extend beyond
that date.

     (d) AMENDMENT OF PLAN. The Board may amend, suspend or terminate the Plan
or any portion thereof at any time, provided that no Award granted to a
Participant designated as subject to Section 162(m) by the Board after the date
of such amendment shall become exercisable, realizable or vested, as applicable
to such Award (to the extent that such amendment to the Plan was required to
grant such Award to a particular Participant), unless and until such amendment
shall have been approved by the Company's stockholders.

     (e) STOCKHOLDER APPROVAL. For purposes of this Plan, stockholder approval
shall mean approval by a vote of the stockholders in accordance with the
requirements of Section 162(m) of the Code.

     (f) GOVERNING LAW. The provisions of the Plan and all Awards made hereunder
shall be governed by and interpreted in accordance with the laws of the State of
Delaware, without regard to any applicable conflicts of law.



                                                Adopted by the Board of
                                                Directors on March 28, 1997


                                                To be submitted for approval by
                                                the Stockholders on May 14, 1997




                                        9

<PAGE>   41


                            Appendix C -- Proxy Card


<PAGE>   42
                  
- --------------------------------------------------------------------------------

                                BIOSEPRA INC.

                  PROXY SOLICITED BY THE BOARD OF DIRECTORS

                ANNUAL MEETING OF STOCKHOLDERS - MAY 14, 1997

        Those signing on the reverse side, revoking any prior proxies, hereby 
appoint(s) Jean-Marie Vogel, Timothy J. Barberich and Mark G. Borden, or each
or any of them with full power of substitution, as proxies for those signing on
the reverse side to act and vote at the 1997 Annual Meeting of Stockholders of
BioSepra Inc., and at any adjournments thereof as indicated upon all matters
referred to on the reverse side and described in the Proxy Statement for the
Meeting, and, in their discretion, upon any other matters which may properly
come before the Meeting.

        THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED IN THE MANNER DIRECTED
BY THE UNDERSIGNED STOCKHOLDER(S). IF NO OTHER INDICATION IS MADE, THE PROXIES
SHALL VOTE "FOR" PROPOSAL NUMBERS 1,2,3 AND 4.

        A VOTE FOR THE DIRECTOR NOMINEES AND FOR PROPOSAL NUMBERS 2,3 AND 4 IS
RECOMMENDED BY THE BOARD OF DIRECTORS.

PLEASE VOTE, DATE, AND SIGN ON THE OTHER SIDE AND RETURN PROMPTLY IN THE
ENCLOSED ENVELOPE.

- --------------------------------------------------------------------------------

<PAGE>   43

A [X] PLEASE MARK YOUR
      VOTES AS IN THIS
      EXAMPLE.


<TABLE>
<S>                                                                <C>
                                                                                                               FOR  AGAINST  ABSTAIN
                    FOR all nominees            WITHHOLD           2) Approval of the Company's 1997 Employee  [ ]    [ ]      [ ]
                    listed at right           AUTHORITY to            Stock Purchase Plan.
                   (except as marked     vote for all nominees                                           
                    to the contrary)        listed at right        3) Approval of the Company's 1997 Stock
1) Election of                                                        Incentive Plan.                          [ ]    [ ]      [ ]
   Directors              [ ]                    [ ]                                                     
                                                                   4) To transact such other business as may   [ ]    [ ]      [ ]
                                                                      properly come before the meeting or any
                           Nominees: Jean-Marie Vogel                 adjournment thereof.                                    
INSTRUCTIONS: To withhold            Timothy J. Barberich       
authority to vote for individual     William M. Cousins, Jr.       PLEASE READ THE REVERSE SIDE OF THIS CARD.
nominee(s) mark the "FOR" box        Alexander M. Klibanov, Ph.D.                             
and strike a line through each       Paul A. Looney                HAS YOUR ADDRESS CHANGED?            DO YOU HAVE ANY COMMENTS?
such nominee(s) name in the list     Riccardo Pugliucci                                       
at the right. Your shares will be    William E. Rich, Ph.D.        -------------------------            -------------------------
voted for the remaining nominee(s)   David P. Southwell                                       
                                                                   -------------------------            -------------------------

                                                                   -------------------------            -------------------------
                                                                   PLEASE MARK, SIGN, DATE AND RETURN THE PROXY CARD
                                                                   PROMPTLY USING THE ENCLOSED ENVELOPE.


Signature                                      Date:              Signature                                       Date:
         ---------------------------------          -----------            -----------------------------------         ----------

NOTE: Please sign this proxy exactly as your name appears hereon. Joint owners should each sign personally. Trustees and other
fiduciaries should indicate the capacity in which they sign. If a corporation or partnership, this signature should be that of an
authorized officer who should state his or her title.

</TABLE>



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