CREATIVE MEDICAL DEVELOPMENT INC
DEF 14A, 1998-08-24
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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                       CREATIVE MEDICAL DEVELOPMENT, INC.
                             975 SE Sandy Boulevard
                             Portland, Oregon 97214

                               PROXY STATEMENT AND
                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                            TO BE HELD APRIL 29, 1998

     To the shareholders of Creative Medical Development, Inc.:

     The Annual Meeting of the  shareholders  of Creative  Medical  Development,
Inc.  (the  "Company")  will be  held at the  Company  offices  at 975 SE  Sandy
Boulevard,  Portland,  Oregon 97214 at 10:00 A.M. on April 29,  1998,  or at any
adjournment or postponement thereof, for the following purposes:

     1.   To elect three directors of the Company.

     2.   To approve the Amended and  Restated  1994 Stock Option Plan a copy of
          which is attached hereto.

     3.   To  approve  the  Company's   Amended  and  Restated   Certificate  of
          Incorporation  which increases the authorized  number of shares of the
          Company's Common Stock and Preferred Stock.

     4.   To  transact  such other  business  as may  properly  come  before the
          meeting.

     Details  relating to the above matters are set forth in the attached  Proxy
Statement. All shareholders of record of the Company as of the close of business
on March 31, 1998 will be  entitled to notice of and to vote at such  meeting or
at any adjournment or postponement thereof.

     ALL SHAREHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING. IF YOU DO NOT
PLAN TO ATTEND THE MEETING,  YOU ARE URGED TO SIGN, DATE AND PROMPTLY RETURN THE
ENCLOSED PROXY. A REPLY CARD IS ENCLOSED FOR YOUR  CONVENIENCE.  THE GIVING OF A
PROXY WILL NOT AFFECT YOUR RIGHT TO VOTE IN PERSON IF YOU ATTEND THE MEETING.

                                            BY ORDER OF THE BOARD OF DIRECTORS

April __, 1998                              Michael L. DeBonny
                                            Chief Executive Officer



<PAGE>

                                PROXY STATEMENT

                       CREATIVE MEDICAL DEVELOPMENT, INC.
                             975 SE Sandy Boulevard
                             Portland, Oregon 97214
                            Telephone (503) 230-8034

                         ANNUAL MEETING OF SHAREHOLDERS
                            TO BE HELD APRIL 29, 1998


     This Proxy  Statement is furnished in connection  with the  solicitation of
proxies by the Board of Directors of Creative  Medical  Development,  Inc.  (the
"Company"),  a Delaware  corporation,  of $.01 par value Common  Stock  ("Common
Stock") and $.01 par value Series B Preferred  Stock  ("Preferred  Stock") to be
voted at the Annual Meeting of Shareholders of the Company ("Annual Meeting") to
be held at 10:00 A.M. on April 29, 1998 or at any  adjournment  or  postponement
thereof.  The Company anticipates that this Proxy Statement and the accompanying
form of proxy will be first mailed or given to all  shareholders  of the Company
on or about April 13,  1998.  The shares  represented  by all  proxies  that are
properly  executed and submitted will be voted at the meeting in accordance with
the instructions  indicated thereon.  Unless otherwise  directed,  votes will be
cast for the election of the  nominees  for  directors  hereinafter  named,  for
approval of the Amended and Restated 1994 Stock Option Plan, and for approval of
the Amended and Restated Certificate of Incorporation. The holders of a majority
of the shares  represented  at the Annual  Meeting in person or by proxy will be
required to approve all proposed matters.

     Any  shareholders  giving a proxy may  revoke  it at any time  before it is
exercised by delivering  written  notice of such  revocation to the Company,  by
substituting a new proxy executed at a later date, or by requesting,  in person,
at the Annual Meeting, that the proxy be returned.

     All of the  expenses  involved in  preparing,  assembling  and mailing this
Proxy Statement and the materials  enclosed herewith and all costs of soliciting
proxies will be paid by the Company.  In addition to the  solicitation  by mail,
proxies may be  solicited  by officers  and regular  employees of the Company by
telephone,  telegraph  or  personal  interview.  Such  persons  will  receive no
compensation for their services other than their regular salaries.  Arrangements
will also be made with  brokerage  houses  and other  custodians,  nominees  and
fiduciaries to forward  solicitation  materials to the beneficial  owners of the
shares  held of record by such  persons,  and the  Company  may  reimburse  such
persons for reasonable out of pocket expenses incurred by them in so doing.

                    VOTING SHARES AND PRINCIPAL SHAREHOLDERS

     The  close of  business  on March 31,  1998 has been  fixed by the Board of
Directors  of the  Company  as the  record  date  (the  "Record  Date")  for the
determination  of  shareholders  entitled to notice of and to vote at the Annual
Meeting.  On the record date, there were outstanding  5,554,337 shares of Common
Stock,  and  622,066  shares of Series B  Preferred  Stock,  each share of which
entitles the holder thereof to one vote on each matter which may come before the
Annual Meeting. Cumulative voting for directors is not permitted.

                                        1

<PAGE>



     A  majority  of  the  issued  and  outstanding  shares  entitled  to  vote,
represented  at the meeting in person or by proxy,  constitutes  a quorum at any
shareholders' meeting.

Security Ownership of Certain Beneficial Owners and Management.

The  following  table  sets  forth  certain  information  with  respect  to  the
beneficial  ownership of the Company's Common Stock and Series B Preferred Stock
as of the March 31, 1998,  by (i) each person who is known by the Company to own
of record or beneficially  more than 5% of the Company's Common Stock, (ii) each
of the  Company's  directors and (iii) all directors and officers of the Company
as a group. The stockholders listed in the table have sole voting and investment
powers with respect to the shares indicated.

       Name and Address of                 Number of               Percent of
     Beneficial Owner(1)(2)              Shares Owned             Class (1)(2)
     ----------------------              ------------             ------------

     Michael L. DeBonny (3)               1,791,702                   29.0%
     16101 Parelius Circle
     Lake Oswego, OR 97034

     John E. Hart (4)                       133,039                    2.2%
     Box 2495
     Grass Valley, CA 95945

     Edward S. Smith (5)                    630,532                   10.2%
     921 SW Washington St., Ste. 762
     Portland, OR 97205

     Richard A. Kreitzberg (6)              919,910                   14.9%
     3332 El Dorado Loop South
     Salem, OR 97032

     Ronald J. Gangemi (7)                  697,788                   11.3%
     11950 Willow Valley Road
     Nevada City, CA 95959

     Ronald G. Nutting (8)                  384,223                    6.2%
     7400 S.W. Barnes Rd. Apt. 1213
     Portland, OR



                                        2

<PAGE>



     Dean Witter Reynolds, Custodian
     for R. Andrew Davis (9)               384,223                    6.2%
     253 East 31st Street #1D
     New York, NY 10016

     All officers and directors           2,620,245                   42.4%
     as a group (5 persons)

- ----------

(1) Assumes no exercise or  conversion  of common  stock  purchase  warrants and
underwriter's  warrants  issued in  conjunction  with the Company's  1994 public
offering, outstanding warrants, options or other commitments of the Company that
are  convertible  into or  exercisable  for shares of Common Stock,  except that
Common Stock and Series B Preferred  Stock  obtainable  by persons  named in the
above table upon  exercise  of options is deemed  outstanding  and  beneficially
owned by such persons in calculating their percentage ownership.

(2) Includes shares of Series B Preferred Stock held by the person listed.

(3) Includes  options held by Mr.  DeBonny to purchase  942,670 shares of Common
Stock and  96,304  shares  of  Series B  Preferred  Stock  under  the  Company's
Incentive Stock Option Plan.

(4) Includes  options held by Mr. Hart to purchase 60,000 shares of Common Stock
under the Company's Incentive Stock Option Plan.

(5) Includes options held by Mr. Smith to purchase 92,722 shares of Common Stock
and 9,473 shares of Series B Preferred Stock under the Company's Incentive Stock
Option Plan.

(6) Includes shares owned by Mr. Kreitzberg's spouse. Also includes options held
by Mr.  Kreitzberg to purchase 30,907 shares of Common Stock and 3,158 shares of
Series B Preferred Stock under the Company's Incentive Stock Option Plan

(7) Includes shares owned by Mr. Gangemi's spouse and children.

(8) Includes  options held by Mr.  Nutting to purchase  46,361  shares of Common
Stock and 4,736 shares of Series B Preferred Stock under the Company's Incentive
Stock Option Plan.

(9) Includes options held by Mr. Davis to purchase 15,454 shares of Common Stock
and 1,579 shares of Series B Preferred Stock under the Company's Incentive Stock
Option Plan.

                                        3

<PAGE>


                              ELECTION OF DIRECTORS

     At the Annual Meeting,  the shareholders  will elect three directors of the
Company.  Cumulative  voting is not permitted for the election of directors.  In
the  absence  of  instructions  to  the  contrary,   the  person  named  in  the
accompanying  proxy will vote in favor of the  election  of each of the  persons
named below as the Company's  nominees for directors of the Company.  All of the
nominees are presently  members of the Board of Directors.  Each of the nominees
has consented to be named herein and to serve if elected.  It is not anticipated
that any  nominee  will  become  unable or  unwilling  to accept  nomination  or
election,  but if such should  occur,  the person named in the proxy  intends to
vote for the  election in his stead of such person as the Board of  Directors of
the Company may recommend.

     The following table sets forth certain  information  regarding each nominee
and each executive officer of the Company

      Name               Age                 Office                   Officer or
                                                                       Director
                                                                         Since

Michael L. DeBonny        57        Chief Executive Officer,              May,
                                    President and Treasurer               1997

Edward S. Smith           79        Chairman of the Board of              May,
                                    Directors and Director                1997

John E. Hart              58        Director and Assistant                May,
                                    Secretary                             1997

Robert E. Tuzik           47        Vice President - Sales and            May,
                                    Marketing                             1997

Jeffrey A. Edwards        52        Chief Financial Officer and           May,
                                    Secretary                             1997


     On December 31, 1997,  Ronald G. Nutting retired from his positions as Vice
President and Secretary. On January 21, 1998, Richard A Kreitzberg resigned as a
director and on February 5, 1998,  Joseph J. Barclay resigned as a director.  On
April 2, 1998, Bryan L. Holland's employment as Vice President-Manufacturing was
terminated.

     Directors  hold office for a period of one year from their  election at the
annual meeting of stockholders  and until their  successors are duly elected and
qualified.  Officers of the Company are elected by, and serve at the  discretion
of,  the  Board of  Directors.  None of the  above  individuals  has any  family
relationship  with any other.  Directors  not  employed by the  Company  receive
$1,000 each for attending  Board of Directors'  meetings and $2,500 annually and
are reimbursed for out-of-pocket expenses.

                                        4

<PAGE>


Background

     The  following is a summary of the business  experience  of each  executive
officer and director of the Company for at least the last five years:

Michael L. DeBonny was Chairman of the Board of  Directors  and Chief  Executive
Officer  of  the  Company  from  closing  of  the  Company's  merger  with  OMNI
International Rail Products,  Inc., ("OMNI") on April 30, 1997 through March 31,
1998. He had been Chairman of the Board of Directors and CEO of OMNI from April,
1994 to the closing.  Mr. DeBonny relinquished the title and responsibilities of
Chairman of the Board of Directors as of March 31, 1998,  but continues as Chief
Executive  Officer.  Prior to the acquisition of OMNI in April 1994, Mr. DeBonny
was president of BHP Rail Products,  Inc. and BHP Rail Products (Canada),  Ltd.,
both divisions of Broken Hill  Proprietary  Co., Ltd. Mr. DeBonny is a Certified
Public  Accountant  and holds  B.B.A.  and MBA degrees  from the  University  of
Portland.

Edward S. Smith became  Chairman of the Board of Directors as of March 31, 1998.
He has been a director of the Company since closing of the Company's merger with
OMNI on April 30,  1997 and had been a director of OMNI from 1994 to the closing
of the merger. Mr. Smith is  President/Owner  of Ted Smith & Company.  He is the
former  chairman  and Chief  Executive  Officer of Omark  Industries,  Inc.,  an
international  manufacturer  of  cutting  chain for chain  saws,  hydraulic  log
loaders and  sporting  ammunition.  His business  activity  during the last five
years  has  been  concentrated  on  private  investing  and  board  memberships.
Currently he serves on the Board of Directors  of Georgia Gulf  Corporation  and
Expert Systems Publishing Company.

John E. Hart has been a director of the Company since closing of the merger with
OMNI on April 30, 1997.  Prior to the  Company's  merger with OMNI,  he had been
general  counsel  to the  Company  since  October  1993  and its  Secretary  and
Treasurer  since  June,  1994.  From 1985 to 1994 he was  engaged in the private
practice of law. He resumed his law practice in May,  1997.  Mr. Hart holds a JD
degree  from the  University  of  Southern  California  and a BA degree from the
University of Redlands.

Robert E. Tuzik has been Vice  President  - Sales and  Marketing  of the Company
since closing of the  Company's  merger with OMNI on April 30, 1997. He had been
Vice  President  - Sales and  Marketing  from 1996 to the closing of the merger.
From  1995 to 1996 he owned  and  operated  Talus  Associates,  specializing  in
railway  marketing  and  media  relations.  Prior to that he spent  six years as
engineering  editor of Railway  Track and  Structures,  a  railroad  engineering
journal.  Mr.  Tuzik  holds  a BA in  English  and  MS in  Journalism  from  the
University of Illinois at Chicago and Northwestern University.

                                        5

<PAGE>
<TABLE>
<CAPTION>



Jeffrey A. Edwards has been Chief Financial Officer of the Company since closing
of the Company's merger with OMNI on April 30, 1997. He had been Chief Financial
Officer of OMNI from January 1997 to closing of the merger. From 1992 to 1997 he
operated Profit  Technology  Systems doing financial and management  consulting.
Prior to that he spent four years as  Division  Finance  Director  with  Wendy's
International  . He is a Certified  Public  Accountant  and holds a BS degree in
Finance from the University of Oregon and an MBA from Portland State University.

Executive Compensation

     The following table sets forth certain information concerning  compensation
paid to the  Company's  executive  officers  for the years ended April 30, 1995,
1996 and 1997, respectively.

                                             Summary Compensation Table
                                                                                                      Long-Term
                               Annual Compensation                                                   Compensation
                               --------------------------------------------------------        -------------------------
                                                                   Other
                               Year                                Annual
                               Ended                               Compen-        Options          LTIP      All other
Name and Principal Position    April 30     Salary      Bonus      sation         SARs             Payments  Comp.
- ---------------------------    --------     ------      -----      ------         ----             --------  -----

<S>                            <C>          <C>           <C>         <C>         <C>              <C>       <C>
Michael L. DeBonny             1997         151,814       0           0           618,144          0         0
CEO, President                 1996         120,918     8,026         0              0             0         0
and Treasurer                  1995         120,457       0           0           324,525          0         0

Ronald G. Nutting              1997         106,544       0           0              0             0         0
Executive Vice President       1996          88,179     5,538         0              0             0         0
and Secretary                  1995          87,803       0           0              0             0         0

</TABLE>

Proposal to Approve the Company's Amended and Restated 1994 Stock Option Plan

     In January  1994,  the  Company  adopted  its 1994 Stock  Option  Plan (the
"Plan"),  which  provides for the grant to  employees,  officers,  directors and
consultants  of  options  to  purchase  up to  400,000  shares of Common  Stock,
consisting of both "incentive  stock options" within the meaning of Section 422A
of  the  United  States   Internal   Revenue  Code  of  1986  (the  "Code")  and
"non-qualified" options.  Incentive stock options are issuable only to employees
of the  Company,  while  non-qualified  options  may be issued  to  non-employee
directors,  consultants  and others,  as well as to  employees  of the  Company.
Pursuant to the Agreement for Merger with OMNI Products, Inc. which closed April
30, 1997, the Company  proposes  approval of the Amended and Restated 1994 Stock
Option Plan ("Amended Plan"). The Amended Plan increases the number of shares of
Common  Stock  reserved  for issuance  under the Plan to  3,000,000  shares.  In
addition,  the Amended Plan reserves for issuance  under the plan 500,000 shares
of Series B Preferred Stock. (collectively, "Stock")


                                        6

<PAGE>



     The Plan is administered by the Board of Directors,  which determines those
individuals who shall receive options,  the time period during which the options
may be partially or fully  exercised,  the number of shares of Stock that may be
purchased under each option and the option price.

     The per share  exercise  price of the Stock  subject to an incentive  stock
option may not be less than the fair  market  value of the Stock on the date the
option is  granted.  The per share  exercise  price of the  Stock  subject  to a
non-qualified  option is established by the Board of Directors.  No employee may
be granted in any  fiscal  year of the  Company  options to  purchase  more than
200,000 shares. No person who owns,  directly or indirectly,  at the time of the
granting  of an  incentive  stock  option  to him,  more  than 10% of the  total
combined  voting  power of all  classes of stock of the  Company is  eligible to
receive any incentive stock options under the Plan unless the option price is at
least  110% of the  fair  market  value  of the  Stock  subject  to the  option,
determined on the date of grant.  Nonqualified  options are not subject to these
limitations.

     No incentive  stock option may be  transferred by an optionee other than by
will or the laws of descent  and  distribution,  and during the  lifetime  of an
optionee,  the option  will be  exercisable  only by him or her. In the event of
termination of employment  other than by death or disability,  the optionee will
have three months after such termination during which he or she can exercise the
option.  Upon  termination  of  employment  of an optionee by reason of death or
permanent total disability,  his or her option remains  exercisable for one year
thereafter to the extent it was exercisable on the date of such termination.  No
similar limitation applies to non-qualified options.

     Options under the Plan must be granted  within ten years from the effective
date of the Plan. The incentive  stock options  granted under the Plan cannot be
exercised more than ten years from the date of grant except that incentive stock
options  issued to 10% or greater  stockholders  are limited to five year terms.
All options granted under the Plan provide for the payment of the exercise price
in cash or by delivery to the  Company of shares of Stock  already  owned by the
optionee  having a fair market value equal to the exercise  price of the options
being exercised,  or by a combination of such methods of payment.  Therefore, an
optionee may be able to tender shares of Stock to purchase  additional shares of
Stock and may theoretically exercise all of his stock options with no additional
investment other than his original shares.  Any unexercised  options that expire
or that  terminate  upon any optionee  ceasing to be an officer,  director or an
employee of the Company become available once again for issuance.

     As of April 1, 1998,  options to purchase  2,135,505 shares pf Common Stock
have been granted under the Plan, of which 1,203,567 options have been issued to
the Company's executive officers and directors, as follows. None of such options
have been exercised.

<TABLE>
<CAPTION>

                           Number                Exercise
       Name            Options Granted             Price                Expiration Date
       ----            ---------------             -----                ---------------

<S>                        <C>                <C>                   <C> 
Michael L. DeBonny         942,670 (1)        $0.775, average       From 2/3/00 to 4/30/07

Jeffrey A. Edwards         30,907                  $1.00                    8/26/07

John E. Hart               60,000                  $1.00            From 4/30/02 to 8/26/07

                                          
                                       7
<PAGE>


                           Number                Exercise
       Name            Options Granted             Price                Expiration Date
       ----            ---------------             -----                ---------------

Edward S. Smith            92,722 (1)          $0.755, average       From 2/3/05 to 4/30/07

Robert E. Tuzik            30,907 (1)              $1.05                   11/13/06

</TABLE>

(1)  Substitute  Options issued  pursuant to the Agreement for Merger of CMD and
     OMNI. For no additional  consideration,  the holder is entitled to .1021606
     shares of Series B Preferred  Stock for each share of Common Stock purchsed
     under the option.

     The Company's Board of Directors  recommends that the shareholders  approve
the Amended and Restated 1994 Stock Option Plan. The Board of Directors believes
that options  issuable under the Plan assist the Company in hiring and retaining
officers,  directors,  key employees and  consultants by providing an additional
financial incentive to such individuals.

Proposal  to  Approve  the  Company's   Amended  and  Restated   Certificate  of
Incorporation

     The Company's Board of Directors  recommends that the shareholders  approve
the Amended and Restated Certificate of Incorporation ("Restated  Certificate"),
which increases the authorized number of shares of Stock to 50,000,000 shares of
Common Stock and  25,000,000  shares of Preferred  Stock. A copy of the Restated
Certificate is attached hereto.

                              CERTAIN TRANSACTIONS

In February, 1997, three OMNI directors (Messrs. DeBonny,  Kreitzberg and Smith)
purchased   shares  in  OMNI  for  a  total  of  $99,617  at  $3.50  per  share.
Simultaneously,  put agreements were executed  requiring the Company to purchase
those shares at a price  equivalent  to $4.00 per share 120 days  following  the
investment.  Mr. Kreitzberg exercised his put and his shares were repurchased in
June, 1997. The put agreements with Messrs. DeBonny and Smith have been extended
on two  occasions  and the put price  adjusted.  Currently,  they have  deferred
exercise of the puts until April 2, 1999.  The price of the put will be adjusted
to reflect an 11% per annum return on the investment.

In March,  1997, OMNI entered into a short term equipment  rental agreement with
one of its directors, Edward S. Smith. As an accommodation,  Mr. Smith purchased
three sets of forms for  production of certain  concrete  crossings at a cost of
$94,820.  The forms  are  currently  rented to OMNI  month to month at a monthly
rental of $1,580.33.

In June,  1997,  the  Company  entered  into an  agreement  with John E. Hart to
provide certain consulting, investor relations and legal services. The agreement
provides for a retainer of $2,500 per month which covers up to twenty-five hours
of services.  In addition,  in  connection  with a proposed  transaction  with a
German company,  Mr. Hart provided  services in connection with negotiations and
documentation of the  transaction,  on a flat fee basis which included an option
to purchase 10,000 shares of the Company's Common Stock at $1.00 per share.



                                        8

<PAGE>



As a condition of the merger  transaction  with OMNI,  the Company  entered into
agreements  with  Messrs.  Hart and  Gangemi to exchange  all of their  Series A
preferred stock (60,000 and 750,000 shares  respectively) for 20,000 and 250,000
shares, respectively, of Series B preferred stock.

Management is of the opinion that all  transactions  described above between the
Company and its officers,  directors or  stockholders  were on terms at least as
fair to the Company as had the transactions  been concluded with an unaffiliated
party. All material  transactions effected in the future between the Company and
its officers,  directors and principal  stockholders will be subject to approval
by a majority of the Company's  outside  directors not having an interest in the
transaction.

                  RELATIONSHIP WITH INDEPENDENT PUBLIC ACCOUNTS

     KPMG  Peat  Marwick  LLP  conducted  the audit of the  Company's  financial
statements for the year ended April 30, 1997. It is the Company's  understanding
that this firm is obligated to maintain audit  independence as prescribed by the
accounting  profession and certain  requirements  of the Securities and Exchange
Commission.  As a result,  the  directors  of the  Company  do not  specifically
approve,  in  advance,  non-audit  services  provided  by the firm,  nor do they
consider the effect, if any, of such services on audit independence.

                                 OTHER BUSINESS

     Management of the Company is not aware of any other matters which are to be
presented to the Annual Meeting, nor has it been advised that other persons will
present any such matters.  However,  if other  matters  properly come before the
meeting,  the  individual  named in the  accompanying  proxy  shall vote on such
matters in accordance with his best judgment.

     The  above  notice  and Proxy  Statement  are sent by order of the Board of
Directors.

                                             Michael L. DeBonny
                                             Chief Executive Officer

April __, 1998

                                        9

<PAGE>



           THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS

                                      PROXY
                    FOR THE ANNUAL MEETING OF SHAREHOLDERS OF
                       CREATIVE MEDICAL DEVELOPMENT, INC.
                            TO BE HELD APRIL 29, 1998


     The  undersigned  hereby  appoints  Edward S.  Smith or John E. Hart as the
lawful agent and Proxy of the  undersigned  (with all the powers the undersigned
would possess if personally present, including full power of substitution),  and
hereby  authorizes  him to represent and to vote, as designated  below,  all the
shares  of  Common  Stock  and  Series B  Preferred  Stock of  Creative  Medical
Development,  Inc. held of record by the  undersigned  on March 31, 1998, at the
Annual Meeting of  Shareholders to be held April 29, 1998, or any adjournment or
postponement thereof.

     1. ELECTION OF DIRECTORS

     _____     FOR the  election  as a director  of all  nominees  listed  below
               (except as marked to the contrary below).

     _____     WITHHOLD AUTHORITY to vote for all nominees listed below:
     

     NOMINEES: Michael L. DeBonny, John E. Hart, Edward S. Smith

INSTRUCTION:  To withhold authority to vote for individual nominees, write their
names in the space provided below.

- --------------------------------------------------------------------------------

     2. To approve the Company's Amended and Restated 1994 Stock Option Plan.

         FOR _____                 AGAINST ____          WITHHOLD VOTE _____

     3.  To  approve  the  Company's   Amended  and  Restated   Certificate   of
Incorporation.

         FOR _____                 AGAINST ____          WITHHOLD VOTE _____

     4. In his  discretion,  the Proxy is  authorized  to vote upon any  matters
which may  properly  come  before  the Annual  Meeting,  or any  adjournment  or
postponement thereof.

     It is understood that when properly  executed,  this proxy will be voted in
the manner directed herein by the  undersigned  shareholder.  WHERE NO CHOICE IS
SPECIFIED  BY THE  SHAREHOLDER  THE  PROXY  WILL BE VOTED  FOR THE  ELECTION  OF
DIRECTORS  NAMED IN ITEM 1 ABOVE AND FOR THE  PROPOSALS SET FORTH IN ITEMS 2 AND
3, ABOVE.


                                        1

<PAGE>


     The undersigned  hereby revokes all previous proxies relating to the shares
covered hereby and confirms all that said Proxy may do by virtue hereof.

     Please sign  exactly as name appears  below.  When shares are held by joint
tenants,  both should sign. When signing as attorney,  executor,  administrator,
trustee or guardian,  please give full title as such. If a  corporation,  please
sign in full  corporate  name by President  or other  authorized  officer.  If a
partnership, please sign in partnership name by authorized person.


Dated:                                    --------------------------------------
                                          Signature

PLEASE MARK, SIGN, DATE AND
RETURN THE PROXY CARD
PROMPTLY USING THE ENCLOSED
ENVELOPE.                                 --------------------------------------
                                          Signature, if held jointly

     PLEASE CHECK THIS BOX IF YOU INTEND TO BE PRESENT AT THE ANNUAL  MEETING OF
SHAREHOLDERS. _____

                                        2


<PAGE>




                              AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION
                                       OF
                       CREATIVE MEDICAL DEVELOPMENT, INC.


     The following Amended and restated Certificate of Incorporation of Creative
Medical Development,  Inc. originally  incorporated on June 1, 1993 which amends
and supersedes the heretofore  existing  Certificate of Incorporation  including
all  amendments  made  thereto  was  duly  adopted  by the  stockholders  of the
Corporation.

     FIRST: The name of the corporation is Creative Medical Development, Inc.

     SECOND:  The registered office of the corporation is located at 1209 Orange
Street, County of New Castle,  Wilmington,  DE 19801. The name of its registered
agent at that address is The Corporation Trust Company.

     THIRD:  The purpose of the  corporation is to engage in any lawful activity
for which corporations may be organized under the General Corporation Law of the
State of Delaware.

     FOURTH:

     A. The corporation  may issue a total of seventy five million  (75,000,000)
shares of stock,  of which  twenty five  million  (25,000,000)  shares  shall be
preferred stock, $.01 par value, and fifty million  (50,000,000) shares shall be
common stock, $.01 par value.

     B. The Board of Directors is authorized,  subject to limitations prescribed
by law and the provisions of this Article FOURTH, to provide for issuance of the
shares of Preferred Stock in series, and by filing a certificate pursuant to the
applicable  law of the State of  Delaware,  to  establish  from time to time the
number of shares  to be  included  in each such  series  and the  voting  powers
thereof,  full or limited, and to fix the designation,  powers,  preferences and
rights of the shares of each such series and the qualifications,  limitations or
restrictions thereof.

     The authority of the Board with respect to each series shall  include,  but
not be limited to, determination of the following:

          1. The number of shares  constituting  that series and the distinctive
     designation of that series;


                                        1

<PAGE>



          2. The dividend rate on the shares of that series,  whether  dividends
     shall be cumulative, and, if so, from which date or dates, and the relative
     rights of  priority,  if any,  of  payment of  dividends  on shares of that
     series;

          3. Whether that series  shall have voting  rights,  in addition to the
     voting rights provided by law, and, if so, the terms of such voting rights;

          4. Whether that series shall have conversion  privileges,  and, if so,
     the  terms and  conditions  of such  conversion,  including  provision  for
     adjustment of the conversion  rate in such events as the Board of Directors
     shall determine;

          5. Whether or not the shares of that series shall be redeemable,  and,
     if so, the terms and conditions of such  redemption,  including the date or
     date upon or after which they shall be redeemable, and the amount per share
     payable  in case of  redemption,  which  amount  may vary  under  different
     conditions and at different redemption dates;

          6. Whether that series shall have a sinking fund for the redemption or
     purchase of shares of that series, and, if so, the terms and amount of such
     sinking fund;

          7. The rights of the shares of that  series in the event of  voluntary
     or involuntary  liquidation,  dissolution or winding up of the corporation,
     and the relative  rights of priority,  if any, of payment of shares of that
     series; and

          8. Any other  relative  rights,  preferences  and  limitations of that
     series.

     C. One million  (1,000,000) shares of preferred stock are designated Series
B Preferred Stock with the following powers, preferences and rights:

          1. The Series B Preferred Stock will be  automatically  converted into
     common stock of the  corporation  if the  corporation  reports gross annual
     revenues of  $20,000,000 or annual  pre-tax  earnings of $1,500,000  during
     either the fiscal  year  ending in 1998 or the fiscal  year ending in 1999.
     If, after the reporting of annual revenues and earnings for the fiscal year
     ending in 1999,  the  conversion  has not  occurred,  the Class B Preferred
     Stock will be deemed canceled and of no further force or effect.

          2.  Each  share of  Series  B  Preferred  Stock,  until  converted  or
     canceled,  has voting rights equivalent to one share of common stock of the
     corporation.

                                        2

<PAGE>



          3. The Series B  Preferred  Stock has no  liquidation  preferences  or
     dividend rights.

     FIFTH:  Election of directors  need not be by written  ballot except and to
the extent provided in the by-laws of the corporation.

     SIXTH: The Board of Directors of the Corporation is expressly authorized to
make, alter, amend, change, add to or repeal the by-laws of the corporation, but
the stockholders may make additional  by-laws and may alter or repeal any by-law
whether adopted by them or otherwise.

     SEVENTH: The corporation shall indemnify to the fullest extent permitted by
law  any  person  made  or  threatened  to be  made a  party  to any  action  or
proceeding, whether criminal, civil, administrative or investigative,  by reason
of the fact that he, his testator or intestate is or was a director,  officer or
employee of the  corporation or any  predecessor of the corporation or serves or
served any other enterprise as a director, officer or employee at the request of
the corporation or any predecessor of the corporation.

     EIGHTH:  To the fullest extent permitted by the General  Corporation Law of
the State of  Delaware as the same now exists or may  hereafter  be amended in a
manner more favorable to directors,  a director of the corporation  shall not be
personally  liable to the Corporation or its  stockholders  for monetary damages
for breach of fiduciary duty as a director.

     NINTH:  Whenever a  compromise  or  arrangement  is proposed  between  this
corporation  and  its  creditors  or any  class  of  them  and/or  between  this
corporation  and its  stockholders  or any class of them, any court of equitable
jurisdiction  within the State of Delaware may, on the  application in a summary
way of this  corporation  or of any  creditor or  stockholder  thereof or on the
application of any receiver or receivers  appointed for this  corporation  under
the  provisions  of  Section  291 of  Title  8 of the  Delaware  Code  or on the
application of trustees in dissolution or of any receiver or receivers appointed
for this corporation  under Section 279 of Title 8 of the Delaware Code, order a
meeting of creditors or class of creditors  and/or of the  stockholders or class
of stockholders of this corporation,  as the case may be, to be summoned in such
manner  as  the  said  court  directs.  If a  majority  in  number  representing
three-fourths  in value of the  creditors or class of  creditors,  and/or of the
stockholders or class of stockholders  of the  corporation,  as the case may be,
agree  to any  compromise  or  arrangement  and to any  reorganization  of  this
corporation  as a  consequence  of such  compromise  or  arrangement,  the  said
compromise or arrangement  and the said  reorganization  shall, if sanctioned by
the court to which the said  application  has been  made,  be binding on all the
creditors  or class of  creditors  and/or  on all the  stockholders  or class of
stockholders  of  this  corporation,  as the  case  may  be,  and  also  on this
corporation.

                                        3

<PAGE>



     TENTH: The corporation reserves the right to amend, alter, change or repeal
any provision  contained in this  Certificate of Incorporation in the manner now
or hereafter  prescribed by law, and all rights and powers  conferred  herein on
stockholders, directors and officers are subject to this reserved power.

     Executed this 29th day of April 1998.


                                                 -------------------------------
                                                 Michael L. DeBonny
                                                 Chief Executive Officer


                                        4

<PAGE>

                       CREATIVE MEDICAL DEVELOPMENT, INC.

                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN


     1.  Purposes of the Plan.  The  purposes  of this Stock  Option Plan are to
attract and retain the best  available  personnel for  positions of  substantial
responsibility, to provide additional incentive to the Employees and Consultants
of the Company and to promote the success of the Company's business.

     Options  granted  hereunder  may be either  "incentive  stock  options," as
defined in Section 422 of the  Internal  Revenue  Code of 1986,  as amended,  or
"nonqualified stock options," at the discretion of the Board and as reflected in
the terms of the written option agreement. In addition,  shares of the Company's
Common Stock may be Sold hereunder independent of any Option grant.

     2. Definitions. As used herein, the following definitions shall apply:

          (a)  "Administrator"  shall mean the Board or any of its Committees as
shall be administering the Plan, in accordance with Section 4.(a) of the Plan.

          (b) "Board" shall mean the Board of Directors of the Company.

          (c) "Code" shall mean the Internal Revenue Code of 1986, as amended.

          (d) "Committee" shall mean a committee appointed by the Board in
accordance with Section of the Plan.

          (e) "Common Stock" shall mean the Common Stock of the Company.

          (f)  "Company"  shall  mean  Creative  Medical  Development,  Inc.,  a
Delaware corporation.

          (g)  "Consultant"  shall mean any person who is engaged by the Company
or any Parent or Subsidiary to render consulting services and is compensated for
such consulting services and any Director of the Company whether compensated for
such services or not.

          (h)  "Continuous  Status as an Employee or Consultant"  shall mean the
absence  of any  interruption  or  termination  of  service  as an  Employee  or
Consultant.  Continuous  Status  as an  Employee  or  Consultant  shall  not  be



- --------------------------------------------------------------------------------
1 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative  Medical  Development,
    Inc.) 



<PAGE>



considered  interrupted in the case of: (i) any sick leave,  military  leave, or
any other leave of absence approved by the Company; provided,  however, that for
purposes of Incentive Stock Options,  any such leave is for a period of not more
than ninety days or reemployment upon the expiration of such leave is guaranteed
by contract or statute, provided,  further, that on the ninety-first day of such
leave  (where  re-employment  is not  guaranteed  by contract  or  statute)  the
Optionee's Incentive Stock Option shall automatically  convert to a Nonqualified
Stock Option;  or (ii) transfers between locations of the Company or between the
Company, its Parent, its Subsidiaries or its successor.

          (i) "Director" shall mean a member of the Board.

          (j) "Disability" shall mean total and permanent  disability as defined
in Section 22(e)(3) of the Code.

          (k)  "Employee"  shall  mean  any  person,   including   Officers  and
Directors,  employed  by the  Company or any Parent or  Subsidiary.  Neither the
payment of a  director's  fee by the Company nor service as a Director  shall be
sufficient to constitute "employment" by the Company.

          (l) "Exchange Act" shall mean the Securities  Exchange Act of 1934, as
amended.

          (m) "Fair  Market  Value"  shall  mean,  as of any date,  the value of
Common Stock determined as follows:

               (i) If the  Common  Stock or  Preferred  Stock is  listed  on any
established  stock  exchange  or a national  market  system,  including  without
limitation  the  Nasdaq  National  Market or the Nasdaq  SmallCap  Market of the
Nasdaq Stock Market,  its Fair Market Value shall be the closing sales price for
such stock (or the  closing  bid, if no sales were  reported)  as quoted on such
exchange  or  system  for the  last  market  trading  day  prior  to the time of
determination,  as reported in The Wall Street  Journal or such other  source as
the Administrator deems reliable;

               (ii) If the Common Stock or Preferred  Stock is regularly  quoted
by a recognized securities dealer but selling prices are not reported,  the Fair
Market  Value of Shares of Common  Stock and  Preferred  Stock shall be the mean
between  the high bid and low asked  prices for the Common  Stock and  Preferred
Stock,  respectively,  on the  last  market  trading  day  prior  to the  day of
determination,  as reported in The Wall Street  Journal or such other  source as
the Administrator deems reliable;



- --------------------------------------------------------------------------------
2 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative  Medical  Development,
    Inc.) 

<PAGE>




               (iii) In the  absence  of an  established  market  for the Common
Stock or  Preferred  Stock,  the Fair Market Value shall be  determined  in good
faith by the Administrator.

          (n) "Incentive  Stock Option" shall mean an Option intended to qualify
as an incentive stock option within the meaning of Section 422 of the Code.

          (o)  "Nonqualified  Stock Option" shall mean an Option not intended to
qualify as an incentive  stock  option  within the meaning of Section 422 of the
Code.

          (p) "Notice of Grant" shall mean a written notice  evidencing  certain
terms and conditions of an individual  Option grant. The Notice of Grant is part
of the Option Agreement.

          (q)  "Officer"  shall mean a person  who is an officer of the  Company
within  the  meaning  of  Section  16 of the  Exchange  Act  and the  rules  and
regulations promulgated thereunder.

          (r) "Option" shall mean a stock option granted pursuant to the Plan.

          (s) "Option Agreement" shall mean a written agreement between the
Company and an Optionee  evidencing  the terms and  conditions  of an individual
Option grant. The Option Agreement is subject to the terms and conditions of the
Plan.

          (t)  "Optioned  Stock" shall mean the Common Stock or Preferred  Stock
subject to an Option.

          (u)  "Optionee"  shall mean an Employee or Consultant  who receives an
Option.

          (v)  "Parent"  shall  mean  a  "parent  corporation,"  whether  now or
hereafter existing, as defined in Section 424(e) of the Code.

          (w) "Plan"  shall mean this  Amended and  Restated  1994 Stock  Option
Plan.

          (x) "Preferred  Stock" shall mean the Series B Preferred  Stock of the
Company.



- --------------------------------------------------------------------------------
3 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative  Medical  Development,
    Inc.) 
<PAGE>



          (y) "Rule  16b-3"  shall  mean Rule 16b-3 of the  Exchange  Act or any
successor to Rule 16b-3,  as in effect when  discretion is being  exercised with
respect to the Plan.

          (z) "Sale" or "Sold" shall include, with respect to the sale of Shares
under the  Plan,  the sale of Shares  for  consideration  in the form of cash or
notes,  as well as a grant of Shares  for  consideration  in the form of past or
future services.

          (aa)  "Share"  shall  mean a share of the  Common  Stock or  Preferred
Stock, as adjusted in accordance with Section of the Plan.

          (ab) "Subsidiary" shall mean a "subsidiary  corporation,"  whether now
or hereafter existing, as defined in Section 424(f) of the Code.

     3. Stock Subject to the Plan.  Subject to the  provisions of Section of the
Plan, the maximum  aggregate  number of Shares which may be optioned and/or Sold
under  the Plan is  3,000,000  shares  of Common  Stock  and  500,000  shares of
Preferred  Stock.  The Shares may be  authorized,  but  unissued,  or reacquired
Common Stock.

     If an Option should expire or become  unexercisable  for any reason without
having been exercised in full, the unpurchased Shares which were subject thereto
shall,  unless the Plan shall have been terminated,  become available for future
Option grants and/or Sales under the Plan; provided,  however,  that Shares that
have  actually  been issued under the Plan shall not be returned to the Plan and
shall not become available for future distribution under the Plan.

     4. Administration of the Plan.

          (a) Procedure.

               (i) Multiple  Administrative  Bodies. If permitted by Rule 16b-3,
the Plan may be  administered  by different  bodies with  respect to  Directors,
Officers who are not  Directors,  and  Employees  who are neither  Directors nor
Officers.

               (ii)  Administration  With  Respect  to  Directors  and  Officers
Subject to Section  16(b).  With respect to Option  grants made to Employees who
are also Officers or Directors subject to Section 16(b) of the Exchange Act, the
Plan shall be  administered  by (A) the Board,  if the Board may  administer the
Plan in  compliance  with the rules  governing  a plan  intended to qualify as a
discretionary plan under Rule 16b-3, or (B) a Committee  designated by the Board



- --------------------------------------------------------------------------------
4 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative  Medical  Development,
    Inc.) 

<PAGE>


to administer the Plan,  which Committee shall be constituted to comply with the
rules,  if any,  governing a plan  intended to qualify as a  discretionary  plan
under Rule 16b-3. Once appointed,  such Committee shall continue to serve in its
designated capacity until otherwise directed by the Board. From time to time the
Board may increase the size of the  Committee  and appoint  additional  members,
remove  members  (with or  without  cause)  and  substitute  new  members,  fill
vacancies  (however  caused),  and  remove  all  members  of the  Committee  and
thereafter  directly  administer  the Plan,  all to the extent  permitted by the
rules,  if any,  governing a plan  intended to qualify as a  discretionary  plan
under Rule 16b-3.  With respect to persons subject to Section 16 of the Exchange
Act,  transactions  under the Plan are  intended to comply  with all  applicable
conditions  of Rule 16b- 3. To the extent any provision of the Plan or action by
the  Administrator  fails to so comply, it shall be deemed null and void, to the
extent permitted by law and deemed advisable by the Administrator.

               (iii) Administration With Respect to Other Persons.  With respect
to Option grants made to Employees or Consultants who are neither  Directors nor
Officers of the Company,  the Plan shall be administered by (A) the Board or (B)
a Committee  designated by the Board,  which  Committee  shall be constituted to
satisfy the legal  requirements  relating to the  administration of stock option
plans  under  applicable  corporate  and  securities  laws  and the  Code.  Once
appointed, such Committee shall serve in its designated capacity until otherwise
directed by the Board.  The Board may  increase  the size of the  Committee  and
appoint  additional  members,   remove  members  (with  or  without  cause)  and
substitute new members,  fill vacancies (however caused), and remove all members
of the Committee and thereafter  directly administer the Plan, all to the extent
permitted  by the legal  requirements  relating to the  administration  of stock
option plans under state corporate and securities laws and the Code.

          (b)  Powers of the  Administrator.  Subject to the  provisions  of the
Plan, and in the case of a Committee,  subject to the specific duties  delegated
by the Board to such Committee,  the Administrator shall have the authority,  in
its discretion:

               (i) to grant  Incentive  Stock Options in accordance with Section
422 of the Code, or Nonqualified Stock Options;

               (ii) to authorize  Sales of Shares of Common or  Preferred  Stock
hereunder;

               (iii) to determine, upon review of relevant information, the Fair
Market Value of the Common or Preferred Stock;



- --------------------------------------------------------------------------------
5 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative  Medical  Development,
    Inc.) 

<PAGE>



               (iv) to  determine  the  exercise/purchase  price  per  Share  of
Options to be granted or Shares to be Sold, which  exercise/purchase price shall
be determined in accordance with Section of the Plan;

               (v) to determine the Employees or  Consultants  to whom,  and the
time or times at which,  Options shall be granted and the number of Shares to be
represented by each Option;

               (vi) to determine the Employees or  Consultants  to whom, and the
time or times at  which,  Shares  shall be Sold and the  number  of Shares to be
Sold;

               (vii) to interpret the Plan;

               (viii) to  prescribe,  amend and  rescind  rules and  regulations
relating to the Plan;

               (ix) to determine the terms and provisions of each Option granted
(which  need not be  identical)  and,  with the  consent of the holder  thereof,
modify or amend each Option;

               (x) to determine the terms and  provisions of each Sale of Shares
(which need not be identical)  and,  with the consent of the purchaser  thereof,
modify or amend each Sale;

               (xi) to  accelerate  or defer (with the consent of the  Optionee)
the exercise date of any Option;

               (xii) to accelerate or defer (with the consent of the Optionee or
purchaser of Shares) the vesting  restrictions  applicable  to Shares Sold under
the Plan or pursuant to Options granted under the Plan;

               (xiii)  to  authorize  any  person  to  execute  on behalf of the
Company any instrument  required to effectuate the grant of an Option or Sale of
Shares previously granted or authorized by the Board;

               (xiv)  to  determine  the   restrictions  on  transfer,   vesting
restrictions,  repurchase  rights,  or other  restrictions  applicable to Shares
issued under the Plan;

               (xv) to  effect,  at any  time and  from  time to time,  with the
consent of the affected  Optionees,  the  cancellation of any or all outstanding
Options under the Plan and to grant in  substitution  therefor new Options under



- --------------------------------------------------------------------------------
6 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative  Medical  Development,
    Inc.) 

<PAGE>


the Plan covering the same or different numbers of Shares,  but having an Option
price per Share consistent with the provisions of Section of this Plan as of the
date of the new Option grant;

               (xvi) to establish,  on a case-by-case basis, different terms and
conditions  pertaining  to  exercise  or  vesting  rights  upon  termination  of
employment,  whether  at the  time of an  Option  grant  or Sale of  Shares,  or
thereafter;

               (xvii) to approve forms of agreement for use under the Plan;

               (xviii)  to reduce the  exercise  price of any Option to the then
current  Fair Market  Value if the Fair Market  Value of the Common or Preferred
Stock covered by such Option shall have  declined  since the date the Option was
granted;

               (xix) to determine whether and under what circumstances an Option
may be settled  in cash under  subsection  9(f)  instead of Common or  Preferred
Stock; and

               (xx)  to  make  all  other  determinations  deemed  necessary  or
advisable for the administration of the Plan.

          (c) Effect of Administrator's Decision. All decisions,  determinations
and  interpretations  of the  Administrator  shall be final and  binding  on all
Optionees and any other holders of any Options  granted under the Plan or Shares
Sold under the Plan.

     5. Eligibility.

          (a) Persons  Eligible.  Options may be granted and/or Shares Sold only
to Employees  and  Consultants.  Incentive  Stock Options may be granted only to
Employees.  An Employee  or  Consultant  who has been  granted an Option or Sold
Shares may, if he or she is otherwise eligible,  be granted an additional Option
or Options or Sold additional Shares.

          (b) ISO  Limitation.  To the extent  that the  aggregate  Fair  Market
Value: (i) of Shares subject to an Optionee's Incentive Stock Options granted by
the Company,  any Parent or Subsidiary,  which (ii) become  exercisable  for the
first  time  during any  calendar  year  (under all plans of the  Company or any
Parent or Subsidiary) exceeds $100,000,  such excess Options shall be treated as
Nonqualified Stock Options.  For purposes of this Section 5(b),  Incentive Stock
Options shall be taken into account in the order in which they were granted, and
the Fair Market Value of the Shares shall be determined as of the time of grant.



- --------------------------------------------------------------------------------
7 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative  Medical  Development,
    Inc.) 

<PAGE>



          (c)  Section  Limitations.  Section of the Plan shall apply only to an
Incentive  Stock Option  evidenced by an Option  Agreement  which sets forth the
intention of the Company and the Optionee  that such Option shall  qualify as an
Incentive  Stock  Option.  Section  of the Plan  shall not  apply to any  Option
evidenced by a Option  Agreement  which sets forth the  intention of the Company
and the Optionee that such Option shall be a Nonqualified Stock Option.

          (d) No Right to Continued  Employment.  The Plan shall not confer upon
any Optionee any right with respect to  continuation of employment or consulting
relationship with the Company, nor shall it interfere in any way with his or her
right  or  the  Company's  right  to  terminate  his  employment  or  consulting
relationship at any time, with or without cause.

          (e) Other Limitations. The following limitations shall apply to grants
of Options to Employees:

               (i) No  Employee  shall be  granted,  in any  fiscal  year of the
Company, Options to purchase more than 200,000 Shares.

               (ii)  In  connection  with  his or  her  initial  employment,  an
Employee may be granted  Options to purchase up to an additional  200,000 Shares
which shall not count against the limit set forth in subsection (i) above.

               (iii) The foregoing limitations shall be adjusted proportionately
in connection  with any change in the Company's  capitalization  as described in
Section 11.

               (iv) If an  Option is  canceled  in the same  fiscal  year of the
Company in which it was granted  (other than in  connection  with a  transaction
described  in Section 11),  the  canceled  Option  shall be counted  against the
limits set forth in  subsections  (i) and (ii) above.  For this purpose,  if the
exercise  price of an Option is reduced,  the  transaction  will be treated as a
cancellation of the Option and the grant of a new Option.

     6. Term of Plan. The Plan shall become  effective upon the earlier to occur
of its adoption by the Board or its approval by the  shareholders of the Company
as described in Section of the Plan.  It shall  continue in effect for a term of
ten (10) years, unless sooner terminated under Section of the Plan.

     7. Term of Option. The term of each Option shall be stated in the Notice of
Grant;  provided,  however,  that in the case of an Incentive Stock Option,  the
term shall be ten (10) years from the date of grant or such  shorter term as may



- --------------------------------------------------------------------------------
8 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative  Medical  Development,
    Inc.) 

<PAGE>


be provided in the Notice of Grant.  However,  in the case of an Incentive Stock
Option  granted to an Optionee  who, at the time the  Incentive  Stock Option is
granted, owns stock representing more than ten percent (10%) of the voting power
of all classes of stock of the Company or any Parent or Subsidiary,  the term of
the  Incentive  Stock  Option  shall  be five (5)  years  from the date of grant
thereof or such shorter term as may be provided in the Notice of Grant.

     8. Exercise/Purchase Price and Consideration.

          (a) Exercise/Purchase Price. The per-Share exercise/purchase price for
the Shares to be issued  pursuant  to  exercise  of an Option or a Sale shall be
such price as is  determined by the  Administrator,  but shall be subject to the
following:

               (i) In the case of an Incentive Stock Option

                    (A) granted to an Employee  who, at the time of the grant of
such Incentive Stock Option, owns stock representing more than ten percent (10%)
of the  voting  power of all  classes  of stock of the  Company or any Parent or
Subsidiary,  the per Share  exercise price shall be no less than one hundred ten
percent (110%) of the Fair Market Value per Share on the date of the grant.

                    (B) granted to any other  Employee,  the per Share  exercise
price shall be no less than one hundred  percent (100%) of the Fair Market Value
per Share on the date of grant.

               (ii) In the case of a Nonqualified  Stock Option or Sale, the per
Share exercise/purchase price shall be determined by the Administrator.

               (iii) Any  determination to establish an Option exercise price or
effect a Sale of Common or Preferred Stock at less than Fair Market Value on the
date of the Option grant or  authorization  of Sale shall be  accompanied  by an
express  finding by the  Administrator  specifying  that the sale is in the best
interest of the  Company,  and  specifying  both the Fair  Market  Value and the
Option exercise price or Sale price of the Common or Preferred Stock.

          (b)  Consideration.  The consideration to be paid for the Shares to be
issued upon exercise of an Option or pursuant to a Sale, including the method of
payment,  shall be determined by the Administrator.  In the case of an Incentive
Stock  Option,  the  Administrator   shall  determine  the  acceptable  form  of
consideration at the time of grant. Such consideration may consist of:



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    Inc.) 

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               (i) cash;

               (ii) check;

               (iii) promissory note;

               (iv) transfer to the Company of Shares which

                    (A) in the  case of  Shares  acquired  upon  exercise  of an
Option,  have been owned by the Optionee for more than six months on the date of
surrender, and

                    (B) have a Fair Market Value on the date of surrender  equal
to the aggregate exercise price of the Shares to be acquired;

               (v) delivery of a properly executed exercise notice together with
irrevocable  instructions  to a broker to  promptly  deliver to the  Company the
amount of sale or loan proceeds required to pay the exercise price;

               (vi) such  other  consideration  and  method of  payment  for the
issuance of Shares to the extent permitted by legal requirements relating to the
administration  of stock  option  plans and  issuances  of capital  stock  under
applicable corporate and securities laws and the Code; or

               (vii) any combination of the foregoing methods of payment.

     If the Fair Market Value of the number of whole Shares  transferred  or the
number of whole Shares  surrendered is less than the total exercise price of the
Option, the shortfall must be made up in cash or by check.  Notwithstanding  the
foregoing  provisions of this Section 8.(b), the  consideration for Shares to be
issued  pursuant  to  a  Sale  may  not  include,  in  whole  or  in  part,  the
consideration set forth in subsections (iv) and (v) above.

     9. Exercise of Option.

          (a)  Procedure  for  Exercise;  Rights as a  Shareholder.  Any  Option
granted  hereunder  shall be exercisable at such times and under such conditions
as determined by the Administrator,  including performance criteria with respect
to the Company and/or the Optionee,  and as shall be permissible under the terms
of the Plan.

          An Option may not be exercised for a fraction of a Share.



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10 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative Medical  Development,
     Inc.) 

<PAGE>



          An Option shall be deemed to be exercised  when written notice of such
exercise  has been  given to the  Company  in  accordance  with the terms of the
Option by the person  entitled to exercise  the Option and full  payment for the
Shares with  respect to which the Option is exercised  has been  received by the
Company.  Full payment may, as authorized by the  Administrator,  consist of any
consideration  and method of payment  allowable  under the Option  Agreement and
Section 8.(b) of the Plan.  Each  Optionee who  exercises an Option shall,  upon
notification of the amount due (if any) and prior to or concurrent with delivery
of the certificate representing the Shares, pay to the Company amounts necessary
to satisfy applicable federal, state and local tax withholding requirements.  An
Optionee must also provide a duly executed copy of any stock transfer  agreement
then in effect and determined to be applicable by the  Administrator.  Until the
issuance (as evidenced by the  appropriate  entry on the books of the Company or
of a duly  authorized  transfer  agent of the Company) of the stock  certificate
evidencing  such  Shares,  no right to vote or  receive  dividends  or any other
rights  as a  shareholder  shall  exist  with  respect  to  the  Optioned  Stock
represented  by such stock  certificate,  notwithstanding  the  exercise  of the
Option.  No adjustment  will be made for a dividend or other right for which the
record  date is prior to the date the stock  certificate  is  issued,  except as
provided in Section of the Plan.

          Exercise of an Option in any manner  shall result in a decrease in the
number of Shares which  thereafter  may be  available,  both for purposes of the
Plan and for sale  under  the  Option,  by the  number of Shares as to which the
Option is exercised.

          (b) Termination of Employment or Consulting Relationship. In the event
that an Optionee's  Continuous  Status as an Employee or  Consultant  terminates
(other than upon the Optionee's death or Disability),  the Optionee may exercise
his or her Option,  but only within such period of time as is  determined by the
Administrator, and only to the extent that the Optionee was entitled to exercise
it at the date of termination  (but in no event later than the expiration of the
term of such  Option as set forth in the  Notice  of  Grant).  In the case of an
Incentive Stock Option,  the  Administrator  shall determine such period of time
(in no event to exceed three (3) months from the date of  termination)  when the
Option is granted. If, at the date of termination,  the Optionee is not entitled
to exercise his or her entire Option,  the Shares  covered by the  unexercisable
portion of the Option  shall  revert to the Plan.  If,  after  termination,  the
Optionee  does not  exercise  his or her Option with the time  specified  by the
Administrator, the Option shall terminate, and the Shares covered by such Option
shall revert to the Plan.

          (c) Disability of Optionee. In the event that an Optionee's Continuous
Status as an Employee or  Consultant  terminates  as a result of the  Optionee's
Disability,  the  Optionee  may  exercise  his or her Option at any time  within
twelve  (12) months  from the date of such  termination,  but only to the extent



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     Inc.) 

<PAGE>


that the Optionee  was  entitled to exercise it at the date of such  termination
(but in no event  later than the  expiration  of the term of such  Option as set
forth in the Notice of Grant).  If, at the date of termination,  the Optionee is
not entitled to exercise  his or her entire  Option,  the Shares  covered by the
unexercisable  portion  of the  Option  shall  revert  to the  Plan.  If,  after
termination,  the Optionee  does not exercise his or her Option  within the time
specified  herein,  the Option shall  terminate,  and the Shares covered by such
Option shall revert to the Plan.

          (d) Death of Optionee.  In the event of the death of an Optionee,  the
Option may be exercised at any time within twelve (12) months following the date
of death (but in no event later than the  expiration  of the term of such Option
as set forth in the Notice of Grant),  by the  Optionee's  estate or by a person
who  acquired the right to exercise  the Option by bequest or  inheritance,  but
only to the extent that the  Optionee was entitled to exercise the Option at the
date of death.  If, at the time of  death,  the  Optionee  was not  entitled  to
exercise  his or her  entire  Option,  the Shares  covered by the  unexercisable
portion of the Option shall revert to the Plan. If, after death,  the Optionee's
estate or a person who  acquired  the right to exercise the Option by bequest or
inheritance does not exercise the Option within the time specified  herein,  the
Option shall  terminate,  and the Shares  covered by such Option shall revert to
the Plan.

          (e) Rule 16b-3. Options granted to persons subject to Section 16(b) of
the Exchange Act must comply with Rule 16b-3 and shall  contain such  additional
conditions  or  restrictions  as may be required  thereunder  to qualify for the
maximum  exemption  from  Section 16 of the  Exchange  Act with  respect to Plan
transactions.

          (f) Buyout Provisions.  The Administrator may at any time offer to buy
out, in whole or in part, for a payment in cash or Shares,  an Option previously
granted, based on such terms and conditions as the Administrator shall establish
and communicate to the Optionee at the time that such offer is made.

     10.   Nontransferability  of  Options.  Except  as  otherwise  specifically
provided in the Option Agreement, an Option may not be sold, pledged,  assigned,
hypothecated, transferred or disposed of in any manner other than by will, or by
the laws of descent and  distribution,  and may be exercised during the lifetime
of the Optionee only by the Optionee or, if  incapacitated,  by his or her legal
guardian or legal representative.

     11. Adjustments Upon Changes in Capitalization or Merger.

          (a) Changes in  Capitalization:  Subject to any required action by the
shareholders  of the Company,  the number of shares of Common  Stock  covered by
each outstanding Option and the number of shares of Common Stock which have been



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     Inc.) 

<PAGE>


authorized  for issuance under the Plan but as to which no Options have yet been
granted or Sales made or which have been returned to the Plan upon  cancellation
or  expiration  of an  Option,  as well as the  price  per  share of  Common  or
Preferred   Stock   covered   by  each  such   outstanding   Option,   shall  be
proportionately  adjusted  for any  increase or decrease in the number of issued
shares of Common or Preferred Stock resulting from a stock split,  reverse stock
split,  stock  dividend,  combination  or  reclassification  of  the  Common  or
Preferred  Stock,  or any other  increase  or  decrease  in the number of issued
shares of Common or Preferred Stock effected without receipt of consideration by
the Company; provided, however, that conversion of any convertible securities of
the  Company  shall  not be deemed to have been  "effected  without  receipt  of
consideration."  Such  adjustment  shall  be  made by the  Administrator,  whose
determination in that respect shall be final, binding and conclusive.  Except as
expressly  provided herein, no issuance by the Company of shares of stock of any
class,  or  securities  convertible  into  shares of stock of any  class,  shall
affect,  and no adjustment by reason  thereof shall be made with respect to, the
number or price of shares of Common or Preferred Stock subject to an Option.

          (b)  Dissolution  or  Liquidation.   In  the  event  of  the  proposed
dissolution  or  liquidation  of  the  Company,  each  outstanding  Option  will
terminate  immediately prior to the consummation of such proposed action, unless
otherwise provided by the Administrator.  The Administrator may, in the exercise
of its  sole  discretion  in such  instances,  declare  that  any  Option  shall
terminate  as of a date fixed by the Board and give each  Optionee  the right to
exercise  his  or her  Option  as to all or  any  part  of the  Optioned  Stock,
including Shares as to which the Option would not otherwise be exercisable.

          (c) Merger or Asset  Sale.  In the event of a proposed  sale of all or
substantially  all of the assets of the  Company,  or the merger of the  Company
with or into another corporation, each outstanding Option shall be assumed or an
equivalent option shall be substituted by such successor corporation or a Parent
or  Subsidiary  of  such  successor   corporation,   unless  the   Administrator
determines,  in the  exercise  of  its  sole  discretion  and in  lieu  of  such
assumption or  substitution,  that the Optionee shall have the right to exercise
the Option as to all of the  Optioned  Stock,  including  Shares as to which the
Option would not otherwise be exercisable.  If the Administrator makes an Option
fully exercisable in lieu of assumption or substitution in the event of a merger
or sale of assets,  the Administrator  shall notify the Optionee that the Option
shall be fully  exercisable  for a period of  thirty  (30) days from the date of
such  notice or such  shorter  period as the  Administrator  may  specify in the
notice,  and the Option will terminate  upon the expiration of such period.  For
the  purposes of this  paragraph,  the Option  shall be  considered  assumed if,
following  the  merger  or sale of  assets,  the  Option  confers  the  right to
purchase,  for each Share of Optioned  Stock  subject to the Option  immediately
prior to the merger or sale of assets,  the consideration  (whether stock, cash,



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     Inc.) 

<PAGE>


or other  securities  or  property)  received in the merger or sale of assets by
holders  of  Common  Stock  for each  Share  held on the  effective  date of the
transaction (and if holders were offered a choice of consideration,  the type of
consideration  chosen by the holders of a majority of the  outstanding  Shares);
provided,  however, that if such consideration received in the merger or sale of
assets was not solely common stock of the successor  corporation  or its Parent,
the  Administrator  may, with the consent of the successor  corporation  and the
Optionee,  provide for the consideration to be received upon the exercise of the
Option,  for each Share of Optioned  Stock  subject to the Option,  to be solely
common  stock of the  successor  corporation  or its Parent equal in Fair Market
Value to the per share consideration  received by holders of Common or Preferred
Stock in the merger or sale of assets.

     12. Time of Granting Options. The date of grant of an Option shall, for all
purposes,  be the  date on  which  the  Administrator  makes  the  determination
granting  such  Option.  Notice  of the  determination  shall  be  given to each
Optionee within a reasonable time after the date of such grant.

     13. Amendment and Termination of the Plan.

          (a)  Amendment and  Termination.  The Board may amend or terminate the
Plan from time to time in such respects as the Board may deem advisable.

          (b)  Shareholder  Approval.   The  Company  shall  obtain  shareholder
approval of any Plan  amendment to the extent  necessary and desirable to comply
with  Rule  16b-3 or with  Section  422 of the Code  (or any  successor  rule or
statute or other applicable law, rule or regulation,  including the requirements
of any  exchange  or  quotation  system on which the  Common  Stock is listed or
quoted).  Such shareholder  approval,  if required,  shall be obtained in such a
manner  and to such a degree  as is  required  by the  applicable  law,  rule or
regulation.

          (c)  Effect  of  Amendment  or  Termination.  Any  such  amendment  or
termination  of the Plan  shall not affect  Options  already  granted,  and such
Options  shall  remain  in full  force  and  effect as if this Plan had not been
amended or terminated, unless mutually agreed otherwise between the Optionee and
the Administrator, which agreement must be in writing and signed by the Optionee
and the Company.

     14. Conditions Upon Issuance of Shares. Shares shall not be issued pursuant
to the  exercise  of an Option or a Sale  unless the  exercise of such Option or
consummation  of the Sale and the issuance and delivery of such Shares  pursuant
thereto  shall comply with all relevant  provisions of law,  including,  without
limitation, the Securities Act of 1933, as amended,  applicable state securities



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     Inc.) 

<PAGE>

laws, the Exchange Act, the rules and regulations  promulgated  thereunder,  and
the requirements of any stock exchange  (including NASDAQ) upon which the Shares
may then be listed,  and shall be further subject to the approval of counsel for
the Company with respect to such compliance.

     15. Reservation of Shares. The Company,  during the term of this Plan, will
at all  times  reserve  and keep  available  such  number  of Shares as shall be
sufficient to satisfy the requirements of the Plan.

     16. Liability of Company.

          (a) Inability to Obtain Authority.  Inability of the Company to obtain
authority  from any  regulatory  body having  jurisdiction,  which  authority is
deemed by the Company's  counsel to be necessary to the lawful issuance and sale
of any Shares  hereunder,  shall relieve the Company of any liability in respect
of the failure to issue or sell such Shares as to which such requisite authority
shall not have been obtained.

          As a condition to the exercise of an Option or a Sale, the Company may
require  the person  exercising  such Option or to whom Shares are being Sold to
represent  and warrant at the time of any such  exercise or Sale that the Shares
are being  purchased only for  investment  and without any present  intention to
sell or  distribute  such Shares if, in the opinion of counsel for the  Company,
such  a  representation  is  required  by any  of  the  aforementioned  relevant
provisions of law.

          (b) Grants Exceeding Allotted Shares. If the Optioned Stock covered by
an Option  exceeds,  as of the date of grant,  the number of Shares which may be
issued under the Plan without additional shareholder approval, such Option shall
be void with respect to such excess Optioned Stock, unless shareholder  approval
of an amendment sufficiently increasing the number of Shares subject to the Plan
is timely obtained in accordance with Section 13 of the Plan.

     17.  Shareholder  Approval.  Continuance  of the Plan  shall be  subject to
approval by the  shareholders of the Company within twelve (12) months before or
after the date the Plan is adopted.  Such shareholder approval shall be obtained
in the manner and to the degree required under applicable federal and state law.



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15 - AMENDED AND RESTATED 1994 STOCK OPTION PLAN (Creative Medical  Development,
     Inc.) 



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