XECHEM INTERNATIONAL INC
SC 13D, 1997-08-11
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                 SCHEDULE 13D

                   Under the Securities Exchange Act of 1934
                              (Amendment No.   )*

                          Xechem International, Inc.
                               (Name of Issuer)

                  Common Stock, par value $0.00001 per share
                        (Title of Class of Securities)

                                  983895-10-3
                                (CUSIP Number)

Renuka Misra, Xechem International, Inc., 100 Jersey Avenue, Building B, Suite
310
                New Brunswick, New Jersey 08901 (908) 247-3300
(Name,  Address and Telephone  Number of Person  Authorized to Receive Notices
and Communications)

                                   Copy to:
  Michael H. Margulis, Esq., Duane, Morris & Heckscher, 122 East 42nd Street
                   New York, New York  10168, (212) 692-1030

                                  August 1, 1997
            (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box: [ ]


Note: Six copies of this  statement,  including all exhibits,  should be filed
with the  Commission.  See Rule  13d-1(a) for other parties to whom copies are
to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


<PAGE>


- ------------------------------------------------------------------------------
                                  SCHEDULE 13D
- ------------------------------------------------------------------------------

 CUSIP NO. 983895-10-3                                      Page 2 of 15 Pages


                    *SEE INSTRUCTIONS BEFORE FILLING OUT!
   INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7 (INCLUDING
          EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.
1)    Names of Reporting Persons
      S.S. or I.R.S. Identification Nos. of Above Persons

      Renuka Misra
2)    Check the Appropriate Box if a Member of a Group*               (a) [  ]
                                                                      (b) [  ]

3)    SEC Use Only

4)    Source of Funds*
      00

5)    Check if Disclosure of Legal  Proceedings is Required  Pursuant to Items
2(d) or 2(e)                                                               [ ]

6)    Citizenship or Place of Organization

      United States
- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------
- ------------------------------------------------------------------------------
                                  Number of
- ------------------------------------------------------------------------------
                                    Shares
                                 Beneficially
                                Owned by Each
                            Reporting Person With
7)    Sole Voting Power

      0 (But see Items 4 and 5 below)
8)    Shared Voting Power

      0 (But see Items 4 and 5 below)
9)    Sole Dispositive Power

      2,305,400 (But see Items 4 and 5 below)
10)   Shared Dispositive Power

      0 (But see Items 4 and 5 below)

11)   Aggregate Amount Beneficially Owned By Each Reporting Person

      2,305,400 (But see Items 4 and 5 below)

12)   Check if the Aggregate Amount in Row  (11) Excludes Certain Shares*


13)   Percent of Class Represented by Amount in Row (11)

       1.9%

14)   Type of Reporting Person*

      IN


<PAGE>


- ------------------------------------------------------------------------------

- ------------------------------------------------------------------------------

                              Page 6 of 15 Pages
Item 1.     Security and Issuer

      The class of equity  securities  to which  this  statement  relates is the
common  stock,  par value  $0.00001  per share (the "Common  Stock"),  of Xechem
International,  Inc.,  a Delaware  corporation  (the  "Company"),  which has its
principal  executive  offices at 100 Jersey  Avenue,  Building B, Suite 310, New
Brunswick, New Jersey 08901.

Item 2.     Identity and Background

      This  statement is filed by Dr. Renuka Misra.  Dr. Misra is the Director
of Natural  Products  of the  Company.  She is a citizen of the United  States
and her  business  address is 100 Jersey  Avenue,  Building B, Suite 310,  New
Brunswick, New Jersey 08901.

      During the last five  years,  Dr.  Misra has not (i) been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
(ii) been a party to a civil proceeding of a judicial or administrative  body of
competent jurisdiction and as a result of such proceeding was or is subject to a
judgment,  decree, or final order enjoining future violations of, or prohibiting
or mandating  activities subject to, federal or state securities laws or finding
any violation with respect to such laws.


Item 3.     Source and Amount of Funds or Other Consideration

      On August 1, 1997, Dr. Misra acquired 2,000,000 shares of Common Stock for
$.05 per share. The source of funds for such purchase was personal funds.


Item 4.   Purpose of Transaction

      On November 18, 1996,  the Company,  David Blech,  and Dr.  Ramesh  Pandey
entered into a Stock Purchase  Agreement (the "Blech  Purchase  Agreement").  On
August 1, 1997,  pursuant to an assignment  of rights from Mr. Blech,  Dr. Misra
acquired  2,000,000 of the shares of Common Stock subject to the Blech  Purchase
Agreement.

      In accordance with the Blech Purchase Agreement,  Dr. Misra also agreed to
be party to a Stockholders Agreement (the "Stockholders  Agreement"),  the terms
of which have  previously  been described in a Schedule 13D filed by Dr. Pandey,
which description is incorporated herein by reference.

      Also on August 1, 1997,  Dr. Misra entered into an agreement  (the "Voting
Agreement")  with Dr.  Pandey,  pursuant to which Dr.  Misra  agreed to vote all
shares  of  capital  stock of the  Company  beneficially  owned  by her,  now or
hereafter,  in the manner  directed by Dr.  Pandey,  on all matters which may be
presented to stockholders, except to the extent such agreement may conflict with
Dr. Misra's obligations under the Stockholders Agreement. Dr. Misra also granted
Dr. Pandey a proxy to vote such shares in accordance with the Voting Agreement.


<PAGE>


- ------------------------------------------------------------------------------
      Dr.  Misra also  holds  options  (the  "Misra  Options")  to  purchase  an
aggregate  of  132,000  shares of Common  Stock,  comprised  of (i)  options  to
purchase  125,000 shares at a purchase price of $.01 per share at any time until
October 23, 2001,  (ii) options to purchase  5,000 shares at a purchase price of
$.25  per  share,   which  options  become  exercisable  in  five  equal  annual
installments,  the first of which became exercisable August 30, 1996, and all of
which expire August 29, 2005,  and (iii)  options to purchase  2,000 shares at a
purchase price of $.25 per share, which options become exercisable in five equal
annual  installments,  the first of which became  exercisable June 25, 1997, and
all of which expire June 24, 2006.
- ------------------------------------------------------------------------------

      As a result of the Stockholders  Agreement and the Voting  Agreement,  Dr.
Misra may be deemed a member of a "group" for  purposes  of Section  13(d) under
the Securities  Exchange Act of 1934, as amended,  and thereby  required to make
disclosure  on this  Schedule  13D. The filing of this Schedule 13D shall not be
deemed  an  admission  by Dr.  Misra  that she is a member of such a group or is
required to make this filing.

      Other than as described above, Dr. Misra has no present plans or proposals
which  relate  to or would  result  in:  (i) the  acquisition  by any  person of
additional  securities of the Company,  or the  disposition of securities of the
Company;  (ii)  an  extraordinary  corporate  transaction,  such  as  a  merger,
reorganization or liquidation, involving the Company or any of its subsidiaries;
(iii) a sale or transfer of a material amount of assets of the Company or any of
its  subsidiaries;  (iv)  any  change  in the  present  Board  of  Directors  or
management of the Company, including any plans or proposals to change the number
or term of  directors or to fill any  existing  vacancies on the Board;  (v) any
material change in the present capitalization or dividend policy of the Company;
(vi) any other material change in the Company's business or corporate structure;
(vii) changes in the Company's  charter,  by-laws or  instruments  corresponding
thereto or other  actions  which may impede  the  acquisition  of control of the
Company by any person; (viii) causing a class of securities of the Company to be
delisted from a national  securities exchange or to cease to be authorized to be
quoted in an inter-dealer  quotation system of a registered  national securities
association;  (ix) a class of equity securities of the Company becoming eligible
for termination of registration  pursuant to Section 12(g)(4) of the Act; or (x)
any action similar to any of those  enumerated  above.  However,  Dr. Misra,  as
Director of Natural  Products of the Company,  from time to time  considers such
transactions on behalf of the Company in the ordinary course of business. Item 4
disclosure  provisions regarding any plans or proposals to make any changes in a
company's  investment  policy for which a vote is  required by Section 13 of the
Investment Company Act of 1940 are inapplicable.


Item 5.  Interest in Securities of the Issuer

      Dr. Misra beneficially owns 2,305,400 shares of Common Stock, comprised of
2,173,000  shares of Common Stock  directly by Dr.  Misra and 127,400  shares of
Common  Stock  issuable on exercise of options held by Dr.  Misra,  representing
1.9% of the  outstanding  shares  of Common  Stock  (based  on an  aggregate  of
118,327,839  shares of Common  Stock  outstanding  as of August 1,  1997,  which
information has been furnished by the Company). The shares beneficially owned do
not include 4,600 shares of Common Stock issuable on exercise of options held by
Dr. Misra which are not exercisable  within 60 days of the date of this Schedule
13D.

      Except as set forth above,  Dr. Misra has not purchased or sold any shares
of Common Stock or securities  exercisable for or convertible  into Common Stock
during the past 60 days.


<PAGE>


      Except as  described  above or in Item 4, (a) Dr. Misra has the sole power
to vote and dispose of the shares of Common  Stock  owned of record by her,  (b)
Dr. Misra does not share with any other person the power to direct the voting or
disposition of the shares of Common Stock  beneficially owned by her, and (c) no
person  other than Dr. Misra has the right to receive or the power to direct the
receipt  of  dividends  from,  or the  proceeds  from the sale of, any shares of
Common Stock owned beneficially by Dr. Misra.


Item 6.     Contracts, Arrangements, Understandings or Relationships with
 Respect to Securities of the Issuer

      The Blech  Purchase  Agreement,  the  Stockholders  Agreement,  the Voting
Agreement, and the Misra Options are described in Items 4 and 5 above.

      In September  1996, Dr. Misra loaned the Company  $115,000,  and holds two
notes,  due  September  1997,  bearing  interest  at the rate of 12% per  annum,
representing such loan.

      Except  for  the  above,  Dr.  Misra  is not a  party  to  any  contracts,
arrangements,  understandings,  or  relationships  (legal or otherwise) with any
person with respect to any securities of the Company,  including but not limited
to any  agreements  concerning  (i) transfer or voting of any  securities of the
Company,  (ii)  finder's  fees,  (iii)  joint  ventures,  (iv)  loan  or  option
arrangements,  (v) puts or calls, (vi) guarantees of profits,  (vii) division of
profits or losses, or (viii) the giving or withholding of proxies.


Item 7.     Material to be Filed as Exhibits

      Exhibit     1: Blech  Stock  Purchase  Agreement,  including  Stockholders
                  Agreement  (incorporated  by  reference to Exhibits 2 and 4 to
                  the  Schedule  13D filed by David  Blech and The Edward  Blech
                  Trust)

      Exhibit 2:  Voting Agreement  (incorporated by reference to Exhibit 2 to
                  the Schedule 13D filed by Ramesh C. Pandey)

      Exhibit 3:  Misra Options (filed herewith)

      Exhibit 4:  Promissory Note (filed herewith)



<PAGE>


- ------------------------------------------------------------------------------
                                  SIGNATURES
- ------------------------------------------------------------------------------

      After  reasonable  inquiry and to the best of my knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.


                                               /s/ Renuka Misra
                                             Renuka Misra


Dated: August 6, 1997


<PAGE>


                                                                     EXHIBIT 3
                                      3
                          XECHEM INTERNATIONAL, INC.
                     NON-QUALIFIED STOCK OPTION AGREEMENT


      AGREEMENT,  dated October 24, 1996, between XECHEM INTERNATIONAL,  INC., a
Delaware corporation (the "Company") and Renuka Misra ("Misra").


                            W I T N E S S E T H :


      In  consideration  of the  mutual  promises  made  herein  and the  mutual
benefits to be derived herefrom, the parties hereto agree as follows:

      1. Misra is granted the option to purchase  from the  Company,  subject to
the terms and conditions set forth in this Agreement, all or any part of 250,000
shares of common stock (the "Common Stock"),  of the Company at a purchase price
of $.01 per share  (the  "Options").  All of such  shares  shall be  treated  as
non-qualified stock options.

      2. The shares  subject to the  Options  may be  purchased  by Misra at any
time, in whole or in part,  until the fifth  anniversary of the date hereof,  at
which time the Options shall terminate.

      3. Shares  purchased  pursuant to this Agreement shall be paid for in full
in cash at the time of  purchase.  Upon  receipt of payment,  the Company  shall
issue a certificate or certificates for such shares.  It shall be a condition to
the  performance of the Company's  obligation to issue or transfer  Common Stock
upon  exercise  of  this  option  that  the  optionee  pay,  or  make  provision
satisfactory  to the Company  for the  payment,  of any taxes  (other than stock
transfer  taxes)  which the Company is  obligated to collect with respect to the
issue or transfer of Common Stock upon exercise.

      4. Misra shall have no rights as a stockholder  with respect to any shares
issuable or transferable upon exercise hereof until the date a stock certificate
is issued to her for such shares. Except as otherwise expressly provided herein,
no  adjustment  shall be made for dividends or other rights for which the record
date is prior to the date such stock certificate is issued.

      5. This option is not transferable or assignable otherwise than by will or
the laws of descent and distribution and is exercisable,  during the lifetime of
Misra, only by her or by her legal guardian.

      6.    Nothing  in this  Agreement  shall  confer  to Misra  any right to
become or continue as an employee of the Company at any time.

      7. In the event that  dividends  payable in Common Stock during any fiscal
year of the Company  exceed in the  aggregate  five  percent of the Common Stock
issued and  outstanding  at the  beginning of the year, or in the event there is
during any fiscal  year of the  Company  one or more  splits,  subdivisions,  or
combinations  of shares of Common Stock  resulting in an increase or decrease by
more than five percent of the shares  outstanding  at the beginning of the year,
the number of shares  deliverable  upon the exercise  thereafter  of this option
shall be increased or

<PAGE>


                                                                     EXHIBIT 3
decreased  proportionately,  as the case may be, without change in the aggregate
purchase price. Common Stock dividends,  splits,  subdivisions,  or combinations
during any fiscal  year which do not exceed the  aggregate  five  percent of the
Common  Stock  issued and  outstanding  at the  beginning  of such year shall be
ignored for  purposes of this  Agreement.  All  adjustments  for the fiscal year
shall be made as of the day such action  necessitating  such adjustment  becomes
effective.

      8. In case the Company is merged or consolidated with another corporation,
or in case  the  property  or  stock  of the  Company  is  acquired  by  another
corporation, or in the case of a separation,  reorganization,  or liquidation of
the Company, the Board of Directors of the Company, or the Board of Directors of
any corporation assuming the obligations of the Company hereunder,  shall either
(a)  make  appropriate  provisions  for the  protection  of this  option  by the
substitution  on an equitable  basis of  appropriate  stock of the  Company,  or
appropriate  stock  of  the  merged,  consolidated,   or  otherwise  reorganized
corporation, provided only that the excess of the aggregate fair market value of
the shares subject to this option  immediately  after such substitution over the
purchase  price thereof is not more than the excess of the aggregate fair market
value of the shares subject to this option  immediately before such substitution
over the purchase price  thereof,  or (b) give written notice to Misra that this
option  must be  exercised  within  15 days of the date of such  notice  or this
option will be terminated.

      9. If at any time during the five-year period commencing on the date which
is six months  after the date  hereof,  the  Company  shall file a  registration
statement  (other  than on Form S-4,  Form S-8,  or a  successor  form) with the
Securities and Exchange  Commission (the "Commission") while any Eligible Shares
(as hereinafter  defined) are outstanding,  the Company shall give Misra written
notice of the filing of such  registration  statement  at least 30 days prior to
the effective  date thereof.  When  requested by Misra in writing within 15 days
after  receipt of any such notice,  the Company  shall,  at the  Company's  sole
expense  (other  than the fees and  disbursements  of counsel  for Misra and the
underwriting  discounts,  if any, payable in respect of the Eligible Shares sold
by Misra), register or qualify all or any portion of the Eligible Shares held by
Misra,  concurrently with the registration of such other securities,  all to the
extent  requisite to permit the public offering and sale of such Eligible Shares
through  the  facilities  of  all  appropriate   securities  exchanges  and  the
over-the-counter   market.   Notwithstanding  the  foregoing,  if  the  managing
underwriter  of any such offering shall advise the Company that, in its opinion,
the  distribution  of all or a portion of the  Eligible  Shares  requested to be
included in the registration  concurrently  with the securities being registered
by the Company would adversely affect the distribution of such securities by the
Company for its own account, then the number of shares to be sold by Misra shall
be reduced to such extent as the managing  underwriter  shall request,  provided
that no such  reduction  shall  be made if any  securities  of the  Company  are
included in such registration statement for the account of any person other than
the Company and Misra to the extent permitted by the contractual  rights of such
other selling  stockholders  unless the securities included in such registration
statement  for  such  other  person  shall  have  been  reduced  pro rata to the
reduction  of the Eligible  Shares  which were  requested to be included in such
registration.  As used herein, "Eligible Shares" shall mean any shares of Common
Stock  held by Misra  which were  previously  acquired  or are then  purchasable
pursuant to this  Agreement and which are not then eligible for sale pursuant to
Rule 144 under the Securities Act of 1930, as amended (the "Act").



<PAGE>


      10.  If at any  time  the  Board  of  Directors  shall  determine,  in its
discretion,  that the  listing,  registration,  or  qualification  of any of the
shares subject to this option upon any securities exchange or under any state or
federal law, or the consent or approval of any governmental  regulatory body, is
necessary  or  desirable  as a  condition  hereunder,  this  option  may  not be
exercised in whole or in part unless such listing, registration,  qualification,
consent, or approval shall have been effected or obtained free of any conditions
not acceptable to the Board of Directors.  The Company shall not be obligated to
sell or issue any shares of Common Stock in any manner in  contravention  of the
Act or any state securities law

      11. Misra hereby  represents and warrants to the Company that she (i) is a
sophisticated  investor,  (ii) will acquire any shares of Common Stock hereunder
for her own account (and not for the account of others) for  investment  and not
with a view to the  distribution  thereof,  (iii)  will  not  sell or  otherwise
dispose  of such  shares  without  registration  under  the Act or an  exemption
therefrom,  and the  certificate or  certificates  representing  such shares may
contain a legend to the foregoing effect, (iv) has been given access to the kind
of financial and other  information about the Company as would be contained in a
registration statement filed under the Act, and (v) understands that she may not
sell or otherwise dispose of such shares in the absence of either a registration
statement under the Act or an exemption from the registration  provisions of the
Act.  Misra  further  agrees that any  exercise  of any Options  shall be deemed
confirmation as of the date of such exercise of the representations made in this
Section 11.

      12. All  notices  hereunder  shall be in writing,  and if to the  Company,
shall be delivered  personally  to the Secretary of the Company or mailed to its
principal office,  addressed to the attention of the Secretary, and if to Misra,
shall be  delivered  personally  or mailed to Misra at the address  noted below.
Such addresses may at the address noted below.  Such addresses may be changed at
any time by notice from one party to the other.

      13.  This  Agreement  shall bind and inure to the  benefit of the  parties
hereto and the successors and assigns of the Company and, to the extent provided
in Section 5, the executors,  administrators,  legatees,  heirs, guardians,  and
legal representatives of Misra.

      14. This Agreement  shall be governed by and construed in accordance  with
the laws of the State of New Jersey,  without  giving effect to rules  governing
the conflict of laws.

      IN WITNESS WHEREOF,  the parties hereto have executed this Agreement as of
the day and year first above written.

                           XECHEM INTERNATIONAL, INC.

                                    By:       /s/       Ramesh       C.
                                    Pandey
                                        Ramesh C. Pandey, Ph.D.
                                 President & CEO

                                                      /s/        Renuka
                                    Misra
                                    Renuka Misra
                          1405 Key Parkway East, #201A
                               Frederick, MD 21702


<PAGE>


- ------------------------------------------------------------------------------
                                                                     EXHIBIT 4
- ------------------------------------------------------------------------------
3

                                                                     EXHIBIT 4
1

                               Promissory Note

                                                              October 14, 1996
                                                     New Brunswick, New Jersey

      XECHEM INTERNATIONAL, INC., with an address at 100 Jersey Avenue, Building
B, Suite 310, New Brunswick, New Jersey 08901 (the "Maker"), for value received,
hereby  promises  to pay to Renuka  Misra,  with an address at 1405 Key  Parkway
East, Unit 201A, Frederick,  MD 21702 or registered assigns (the "Holder"),  the
principal  amount of SIXTY-FIVE  THOUSAND  DOLLARS  ($65,000.00),  together with
simple  interest  at the rate of 12% per  annum  (calculated  on the  basis of a
360-day  year  consisting  of twelve  30-day  months),  in a single  payment  of
principal  and  interest,  on March  19,  1997  (the  "Maturity  Date"),  all as
hereafter  further  provided.  If  principal  and  interest  are not paid on the
Maturity Date, the Promissory  Note may be extended an additional six (6) months
to September  19,  1997,  and the simple  interest  will be at a rate of 12% per
annum for the extended period.

      This Note  represents  the Maker's  obligations to repay loans made by the
Holder on September 20, 1996 (the "Loan Date").

      In no event  shall any  interest to be paid  hereunder  exceed the maximum
rate  permitted  by law. In any such  event,  this Note shall  automatically  be
deemed amended to permit interest  charges at an amount equal to, but no greater
than, the maximum rate permitted by law.

      I.    Payments.

      (a)  Interest on this Note shall  accrue on the unpaid  principal  balance
from the most recent date on which interest has been paid or, if no interest has
been  paid on this  Note,  from  the Loan  Date,  to but  excluding  the date of
payment, and shall be payable on the Maturity Date.

      (b) If the  Maturity  Date would fall on a day that is not a Business  Day
(as defined below), the payment due on the Maturity Date may be made on the next
succeeding  Business  Day with  the  same  force  and  effect  as if made on the
Maturity  Date.  "Business  Day" means any day which is not a Saturday or Sunday
and is not a day on which  banking  institutions  are  generally  authorized  or
obligated to close in the City of New York, New York.

      (c) The Maker may, at its option,  prepay all or any part of the principal
of this Note,  without  payment of any premium or penalty.  All payments on this
Note shall be applied  first to accrued  interest  hereon and the balance to the
payment of principal hereof.

      (d) Payments of principal and interest on this Note shall be made by check
sent to the  Holder's  address set forth  above or to such other  address as the
Holder may designate for such purpose from time to time by written notice to the
Maker,  in such coin or currency of the United  States of America as at the time
of payment shall be legal tender for the payment of public and private debts.

      (e) The  obligations  to make the  payments  provided for in this Note are
absolute  and   unconditional   and  not  subject  to  any   defense,   set-off,
counterclaim, rescission, recoupment, or adjustment whatsoever. The Maker hereby
expressly  waives  demand and  presentment  for payment,  notice of  nonpayment,
notice of dishonor,  protest, notice of protest, bringing of suit, and diligence
in taking any action to collect any amount  called for  hereunder,  and shall be
directly and primarily  liable for the payment of all sums owing and to be owing
hereon,  regardless of and without any notice,  diligence, act, or omission with
respect to the collection of any amount called for hereunder.

      a)    Events of Default.

      The occurrence of any of the following events shall constitute an event of
default (an "Event of Default"):

      (a) A default in the payment of any  installment  of principal or interest
on this Note,  when and as the same shall become due and payable,  which default
shall  continue  for five  days  after  the date  fixed  for the  making of such
interest payment.

      (b)  The  entry  of a  decree  or  order  by a court  having  jurisdiction
adjudging  the Maker a bankrupt or  insolvent,  or approving a petition  seeking
reorganization,  arrangement, adjustment, or composition of or in respect of the
Maker,  under federal  bankruptcy law, as now or hereafter  constituted,  or any
other applicable federal or state bankruptcy,  insolvency, or other similar law,
and the  continuance  of any such decree or order  unstayed  and in effect for a
period of 60 days; or the  commencement  by the Maker of a voluntary  case under
federal bankruptcy law, as now or hereafter constituted, or any other applicable
federal or state bankruptcy, insolvency, or other similar law, or the consent by
it to the institution of bankruptcy or insolvency proceedings against it, or the
filing by it of a petition or answer or consent seeking reorganization or relief
under federal  bankruptcy law or any other  applicable  federal or state law, or
the  consent by it to the filing of such  petition  or to the  appointment  of a
receiver,  liquidator,  assignee, trustee,  sequestrator, or similar official of
the Maker or of any substantial part of its property,  or the making by it of an
assignment  for the benefit of  creditors,  or the admission by it in writing of
its  inability  to pay its debts  generally as they become due, or the taking of
action by the Maker in furtherance of any such action.

      b).   Remedies Upon Default.

      (a) Upon the  occurrence  of an Event of  Default  referred  to in Section
2(b), the principal  amount then  outstanding  of, and the accrued  interest on,
this  Note  shall  automatically  become  immediately  due and  payable  without
presentment, demand, protest, or other formalities of any kind, all of which are
hereby expressly waived by the Maker. Upon the occurrence of an Event of Default
referred  to in Section  2(a),  the  Holder,  by notice in writing  given to the
Maker,  may declare the entire  principal  amount then  outstanding  of, and the
accrued interest on, this Note to be due and payable  immediately,  and upon any
such  declaration  the same  shall  become and be due and  payable  immediately,
without presentation,  demand, protest, or other formalities of any kind, all of
which are expressly waived by the Maker.

      (b) The Holder may institute  such actions or proceedings in law or equity
as it shall deem  expedient  for the  protection of his rights and may prosecute
and enforce its claims against all assets of the Maker,  and in connection  with
any such  action or  proceeding  shall be  entitled  to  receive  from the Maker
payment of the principal  amount of this Note plus accrued  interest to the date
of payment plus reasonable expenses of collection including, without limitation,
attorney's fees and expenses.



<PAGE>


      c)    Miscellaneous.

      (a) Any notice or other communication required or at the address set forth
in the  first  paragraph  hereof  permitted  to be given  hereunder  shall be in
writing and shall be mailed by certified mail, return receipt  requested,  or by
Federal Express,  Express Mail or similar overnight  delivery or courier service
or  delivered  (in person or by  telecopy,  telex or similar  telecommunications
equipment)  against  receipt  to the  party  to whom it is to be  given,  at the
address set forth in the first paragraph hereof, or to such other address as the
party shall have furnished in writing in accordance  with the provisions of this
Section 4(a). Notice to the estate of any party shall be sufficient if addressed
to the party as provided in this Section 4(a). Any notice or other communication
given by  certified  mail  shall be  deemed  given at the time of  certification
thereof,  except for a notice  changing a party's  address which shall be deemed
given at the time of receipt thereof.  Any notice given by other means permitted
by this Section 4(a) shall be deemed given at the time of receipt thereof.

      (b) Upon receipt of evidence  reasonably  satisfactory to the Maker of the
loss, theft, destruction, or mutilation of this Note (and upon surrender of this
Note if mutilated), the Maker shall execute and deliver to the Holder a new Note
of like date, tenor, and denomination.

      (c) No  course  of  dealing  and no delay or  omission  on the part of the
Holder in exercising  any right or remedy shall  operate as a waiver  thereof or
otherwise prejudice the Holder's rights,  powers, or remedies.  No right, power,
or remedy conferred by this Note upon the Holder shall be exclusive of any other
right, power, or remedy referred to herein or now or hereafter available at law,
in equity,  by statute,  or  otherwise,  and all such  remedies may be exercised
singly or concurrently.

      (d) This Note may be amended only by a written instrument  executed by the
Maker and the Holder.  Any amendment  shall be endorsed upon this Note,  and all
future Holders shall be bound thereby.

      (e) This Note shall be governed by and  construed in  accordance  with the
laws of the State of New Jersey, without giving effect to conflict of laws.

      IN WITNESS  WHEREOF,  the Maker has caused  this Note to be  executed  and
dated the day and year first above written.

                                          XECHEM INTERNATIONAL, INC.


                                          By:      /s/      Ramesh     C.
                                     Pandey
                                             Name:    Ramesh C. Pandey, Ph.D.
                                             Title:   President/CEO


<PAGE>


- ------------------------------------------------------------------------------
                                                                     EXHIBIT 4
- ------------------------------------------------------------------------------
3

1

                               Promissory Note

                                                            September 18, 1996
                                                     New Brunswick, New Jersey

      XECHEM INTERNATIONAL, INC., with an address at 100 Jersey Avenue, Building
B, Suite 310, New Brunswick, New Jersey 08901 (the "Maker"), for value received,
hereby  promises  to pay to Renuka  Misra,  with an address at 1405 Key  Parkway
East, Unit 201A, Frederick,  MD 21702 or registered assigns (the "Holder"),  the
principal  amount of FIFTY THOUSAND DOLLARS  ($50,000.00),  together with simple
interest at the rate of 10% per annum (calculated on the basis of a 360-day year
consisting  of twelve  30-day  months),  in a single  payment of  principal  and
interest,  on March 2, 1997 (the  "Maturity  Date"),  all as  hereafter  further
provided.  If principal  and interest  are not paid on the  Maturity  Date,  the
Promissory  Note may be extended an  additional  six (6) months to  September 2,
1997,  but the  simple  interest  will be at a rate  of 12%  per  annum  for the
extended period.

      This Note  represents  the Maker's  obligations to repay loans made by the
Holder on September 3, 1996 (the "Loan Date").

      In no event  shall any  interest to be paid  hereunder  exceed the maximum
rate  permitted  by law. In any such  event,  this Note shall  automatically  be
deemed amended to permit interest  charges at an amount equal to, but no greater
than, the maximum rate permitted by law.

      d)    Payments.

      (a)  Interest on this Note shall  accrue on the unpaid  principal  balance
from the most recent date on which interest has been paid or, if no interest has
been  paid on this  Note,  from  the Loan  Date,  to but  excluding  the date of
payment, and shall be payable on the Maturity Date.

      (b) If the  Maturity  Date would fall on a day that is not a Business  Day
(as defined below), the payment due on the Maturity Date may be made on the next
succeeding  Business  Day with  the  same  force  and  effect  as if made on the
Maturity  Date.  "Business  Day" means any day which is not a Saturday or Sunday
and is not a day on which  banking  institutions  are  generally  authorized  or
obligated to close in the City of New York, New York.

      (c) The Maker may, at its option,  prepay all or any part of the principal
of this Note,  without  payment of any premium or penalty.  All payments on this
Note shall be applied  first to accrued  interest  hereon and the balance to the
payment of principal hereof.

      (d) Payments of principal and interest on this Note shall be made by check
sent to the  Holder's  address set forth  above or to such other  address as the
Holder may designate for such purpose from time to time by written notice to the
Maker,  in such coin or currency of the United  States of America as at the time
of payment shall be legal tender for the payment of public and private debts.

      (e) The  obligations  to make the  payments  provided for in this Note are
absolute  and   unconditional   and  not  subject  to  any   defense,   set-off,
counterclaim, rescission, recoupment, or adjustment whatsoever. The Maker hereby
expressly  waives  demand and  presentment  for payment,  notice of  nonpayment,
notice of dishonor,  protest, notice of protest, bringing of suit, and diligence
in taking any action to collect any amount  called for  hereunder,  and shall be
directly and primarily  liable for the payment of all sums owing and to be owing
hereon,  regardless of and without any notice,  diligence, act, or omission with
respect to the collection of any amount called for hereunder.

      e)    Events of Default.

      The occurrence of any of the following events shall constitute an event of
default (an "Event of Default"):

      (a) A default in the payment of any  installment  of principal or interest
on this Note,  when and as the same shall become due and payable,  which default
shall  continue  for five  days  after  the date  fixed  for the  making of such
interest payment.

      (b)  The  entry  of a  decree  or  order  by a court  having  jurisdiction
adjudging  the Maker a bankrupt or  insolvent,  or approving a petition  seeking
reorganization,  arrangement, adjustment, or composition of or in respect of the
Maker,  under federal  bankruptcy law, as now or hereafter  constituted,  or any
other applicable federal or state bankruptcy,  insolvency, or other similar law,
and the  continuance  of any such decree or order  unstayed  and in effect for a
period of 60 days; or the  commencement  by the Maker of a voluntary  case under
federal bankruptcy law, as now or hereafter constituted, or any other applicable
federal or state bankruptcy, insolvency, or other similar law, or the consent by
it to the institution of bankruptcy or insolvency proceedings against it, or the
filing by it of a petition or answer or consent seeking reorganization or relief
under federal  bankruptcy law or any other  applicable  federal or state law, or
the  consent by it to the filing of such  petition  or to the  appointment  of a
receiver,  liquidator,  assignee, trustee,  sequestrator, or similar official of
the Maker or of any substantial part of its property,  or the making by it of an
assignment  for the benefit of  creditors,  or the admission by it in writing of
its  inability  to pay its debts  generally as they become due, or the taking of
action by the Maker in furtherance of any such action.

      f).   Remedies Upon Default.

      (a) Upon the  occurrence  of an Event of  Default  referred  to in Section
2(b), the principal  amount then  outstanding  of, and the accrued  interest on,
this  Note  shall  automatically  become  immediately  due and  payable  without
presentment, demand, protest, or other formalities of any kind, all of which are
hereby expressly waived by the Maker. Upon the occurrence of an Event of Default
referred  to in Section  2(a),  the  Holder,  by notice in writing  given to the
Maker,  may declare the entire  principal  amount then  outstanding  of, and the
accrued interest on, this Note to be due and payable  immediately,  and upon any
such  declaration  the same  shall  become and be due and  payable  immediately,
without presentation,  demand, protest, or other formalities of any kind, all of
which are expressly waived by the Maker.

      (b) The Holder may institute  such actions or proceedings in law or equity
as it shall deem  expedient  for the  protection of his rights and may prosecute
and enforce its claims against all assets of the Maker,  and in connection  with
any such  action or  proceeding  shall be  entitled  to  receive  from the Maker
payment of the principal  amount of this Note plus accrued  interest to the date
of payment plus reasonable expenses of collection including, without limitation,
attorney's fees and expenses.



<PAGE>


      g)    Miscellaneous.

      (a) Any notice or other communication required or at the address set forth
in the  first  paragraph  hereof  permitted  to be given  hereunder  shall be in
writing and shall be mailed by certified mail, return receipt  requested,  or by
Federal Express,  Express Mail or similar overnight  delivery or courier service
or  delivered  (in person or by  telecopy,  telex or similar  telecommunications
equipment)  against  receipt  to the  party  to whom it is to be  given,  at the
address set forth in the first paragraph hereof, or to such other address as the
party shall have furnished in writing in accordance  with the provisions of this
Section 4(a). Notice to the estate of any party shall be sufficient if addressed
to the party as provided in this Section 4(a). Any notice or other communication
given by  certified  mail  shall be  deemed  given at the time of  certification
thereof,  except for a notice  changing a party's  address which shall be deemed
given at the time of receipt thereof.  Any notice given by other means permitted
by this Section 4(a) shall be deemed given at the time of receipt thereof.

      (b) Upon receipt of evidence  reasonably  satisfactory to the Maker of the
loss, theft, destruction, or mutilation of this Note (and upon surrender of this
Note if mutilated), the Maker shall execute and deliver to the Holder a new Note
of like date, tenor, and denomination.

      (c) No  course  of  dealing  and no delay or  omission  on the part of the
Holder in exercising  any right or remedy shall  operate as a waiver  thereof or
otherwise prejudice the Holder's rights,  powers, or remedies.  No right, power,
or remedy conferred by this Note upon the Holder shall be exclusive of any other
right, power, or remedy referred to herein or now or hereafter available at law,
in equity,  by statute,  or  otherwise,  and all such  remedies may be exercised
singly or concurrently.

      (d) This Note may be amended only by a written instrument  executed by the
Maker and the Holder.  Any amendment  shall be endorsed upon this Note,  and all
future Holders shall be bound thereby.

      (e) This Note shall be governed by and  construed in  accordance  with the
laws of the State of New Jersey, without giving effect to conflict of laws.

      IN WITNESS  WHEREOF,  the Maker has caused  this Note to be  executed  and
dated the day and year first above written.

                                          XECHEM INTERNATIONAL, INC.


                                          By:      /s/  Ramesh  C. Pandey
                                              Name:    Ramesh C. Pandey, Ph.D.
                                             Title:   President/CEO




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