XECHEM INTERNATIONAL INC
DEF 14A, 2000-06-22
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a)of the Securities Exchange Act of 1934
                                (Amendment No. )


Filed by the Registrant [X]
Filed by a Party other than the Registrant [ ]

Check the appropriate box:

[ ]  Preliminary Proxy Statement

[ ]  Confidential, for Use of the Commission Only
     (as permitted by Rule 14a-6(e)(2))

[X]  Definitive Proxy Statement

[ ]  Definitive Additional Materials

[ ]  Soliciting Material Pursuant toss.240.14a-12

Xechem International, Inc.
--------------------------------------------------------------------------------

                (Name of Registrant as Specified In Its Charter)
           Shefsky & Froelich Ltd., Suite 2500, 444 N. Michigan Ave.,
                   Chicago, IL 60611 Attn: Dennis B. O'Boyle
--------------------------------------------------------------------------------

                   (Name of Person(s) Filing Proxy Statement)

Payment of Filing Fee (Check the appropriate box)

[X]  No fee required.

[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
     1)   Title of each class of securities to which transaction applies:

          ----------------------------------------------------------------------

     2)   Aggregate number of securities to which transaction applies:

          ----------------------------------------------------------------------

     3)   Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange  Act Rule 0-11 (set forth the amount on which the
          filing fee is calculated and state how it was determined):

          ----------------------------------------------------------------------

     4)   Proposed maximum aggregate value of transaction:

          ----------------------------------------------------------------------

     5)   Total fee paid:

          ----------------------------------------------------------------------

[ ]  Fee paid previously with preliminary materials.
[ ]  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2)  and identify the filing for which the  offsetting  fee was paid
     previously.  Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.

     1)   Amount Previously Paid:

          ----------------------------------------------------------------------

     2)   Form, Schedule or Registration Statement No.:

          ----------------------------------------------------------------------

     3)   Filing Party:

          ----------------------------------------------------------------------

     4)   Date Filed:

          ----------------------------------------------------------------------

<PAGE>

                           XECHEM INTERNATIONAL, INC.
                          100 JERSEY AVENUE, BUILDING B
                                    SUITE 310
                      NEW BRUNSWICK, NEW JERSEY 08901-3279
                                 (732) 247-3300

   ==========================================================================

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
   ==========================================================================


To the Common, Class A Preferred,  Class C Series 4 Preferred and Class C Series
5 Preferred Stockholders of Xechem International, Inc.:

     Notice is  hereby  given  that the  annual  meeting  of  stockholders  (the
"Meeting"  or the "Annual  Meeting") of Xechem  International,  Inc., a Delaware
corporation  (the   "Corporation"),   will  be  convened  at  the  Corporation's
headquarters, 100 Jersey Ave., Building B, Suite 310, New Brunswick, New Jersey,
on July 11, 2000,  at 10:00 a.m.  Eastern  Daylight  Savings Time (the  "Meeting
Date").  All  holders of Common  Stock,  par value  $.00001  per share,  Class A
Preferred Stock, par value $.00001 per share,  Class C Series 4 Preferred Stock,
par value  $.00001 per share,  and Class C Series 5 Preferred  Stock,  par value
$.00001 per share,  of the  Corporation  (the  "Stockholders")  are  entitled to
attend the Meeting. The Annual Meeting will be held for the following purposes:

     (1)  To elect two directors to hold office until the next annual meeting of
          stockholders or otherwise as provided in the Corporation's By-Laws;

     (2)  To amend the  Corporation's  Certificate of  Incorporation to increase
          the number of authorized shares from 250,000,000 to 750,000,000 shares
          consisting of 700,000,000 shares of Common Stock and 50,000,000 shares
          of Preferred Stock;

     (3)  To vote to approve an increase in the number of shares of Common Stock
          which may be issued under the Xechem  International,  Inc. Amended and
          Restated Stock Option Plan; and

     (4)  To  transact  any other  business  as may  properly  come  before  the
          Meeting, or any adjournment or postponement thereof.

     Only  Stockholders  of record at the close of business on June 14, 2000 are
entitled  to receive  notice of the  Meeting  and to vote at the  Meeting or any
adjournment or postponement thereof (the "Eligible Holders"). A list of Eligible
Holders will be available  for  inspection  at the  Corporation's  office for at
least 10 days prior to the Meeting.

                                        By order of the Board of Directors:


                                        Ramesh C. Pandey, Ph.D.
                                        President and Chief Executive Officer

<PAGE>

   ==========================================================================

                                 PROXY STATEMENT
                                       FOR
                        ANNUAL MEETING OF STOCKHOLDERS OF
                           XECHEM INTERNATIONAL, INC.
                                  JULY 11, 2000
   ==========================================================================


     This proxy  statement  (the "Proxy  Statement") is furnished to the holders
(the  "Stockholders") of shares of Common Stock (the "Common Stock"),  par value
$.00001 per share, Class A Preferred Stock (the "Class A Preferred Stock"),  par
value  $.00001  per share,  Class C Series 4  Convertible  Preferred  Stock (the
"Class C Series 4 Preferred  Stock"),  par value $.00001 per share,  and Class C
Series 5 Convertible  Preferred Stock (the "Class C Series 5 Preferred  Stock"),
par value  $.00001  per share  (together,  the Common  Stock,  Class A Preferred
Stock, Class C Series 4 Preferred Stock and Class C Series 5 Preferred Stock are
referred  to as  the  "Shares"),  of  Xechem  International,  Inc.,  a  Delaware
corporation (the "Corporation"),  in connection with the solicitation of proxies
by the  Corporation's  board of  directors  (the  "Board") for use at the annual
meeting  of  Stockholders   (the  "Meeting"  or  the  "Annual   Meeting").   The
Corporation's  By-Laws (the "By-Laws") require the directors to call and hold an
annual meeting of stockholders each year. The Annual Meeting will be convened on
July 11, 2000, at  approximately  10:00 a.m.  Eastern Daylight Savings Time, and
any adjournment or postponement thereof. Copies of this Proxy Statement, and the
enclosed form of proxy were first sent or given to Stockholders on or about June
22,  2000.  Stockholders  who wish to attend  the  Meeting  should  contact  the
Corporation at (732) 247-3300 so that arrangements can be made.

     The Corporation  will bear all costs in connection with the solicitation of
proxies,  including  the cost of  preparing,  printing  and  mailing  this Proxy
Statement.  In addition to the use of the mails, proxies may be solicited by the
Corporation's directors,  officers or employees.  None of these individuals will
be  additionally  compensated,  but they  may be  reimbursed  for  out-of-pocket
expenses in connection  with the  solicitation.  Arrangements  will also be made
with brokerage houses,  banks or other custodians,  nominees and fiduciaries for
the forwarding of solicitation  material to the beneficial  owners of the Shares
held of  record  by those  persons,  and the  Corporation  may  reimburse  these
custodians, nominees and fiduciaries for their reasonable out-of-pocket expenses
incurred in connection therewith.

     Shares  represented by properly  executed proxies in the accompanying  form
received  by the Board prior to the Annual  Meeting  will be voted at the Annual
Meeting.  Shares not represented by properly executed proxies will not be voted.
If a Stockholder specifies a choice with respect to any matter to be acted upon,
the  Shares  represented  by that  proxy  will be  voted  as  specified.  If the
Stockholder does not specify a choice, in an otherwise  properly executed proxy,
with respect to any proposal referred to therein, the Shares represented by that
proxy  will be voted  with  respect  to that  proposal  in  accordance  with the
recommendations  of the Board  described  herein.  A  Stockholder  who signs and
returns a proxy in the  accompanying  form may revoke it by: (i) giving  written
notice of revocation to the Corporation  before the proxy is voted at the Annual
Meeting;  (ii) executing and delivering a later-dated  proxy; or (iii) attending
the Annual Meeting and voting the Shares in person.

     The  close  of  business  on June 14,  2000 has been  fixed as the date for
determining those  Stockholders  entitled to notice of and to vote at the Annual
Meeting (the "Record Date"). On the Record Date, the Corporation had 240,852,928
shares of Common Stock, 2,500 shares of Class A Preferred Stock,  100,000 shares
of Class C Series 4  Preferred  Stock  and  100,000  shares  of Class C Series 5
Preferred Stock  outstanding.  The  Corporation  has also authorized  Class B 8%
Preferred  Stock,  par value $.00001 per share (the "Class B Preferred  Stock").
Presently,  there is no outstanding  Class B Preferred  Stock. The Common Stock,
Class A Preferred Stock , Class C Series 4 Preferred Stock and Class C

<PAGE>

Series 5 Preferred  Stock  entitle the holders  thereof to one,  1,000,  400 and
422.59318  votes  per  share,   respectively,   at  the  Annual  Meeting.   Only
Stockholders  of record as of the Record  Date will be  entitled  to vote at the
Annual  Meeting.  The  presence  of a  majority  of the  total  amount  of votes
allocable to outstanding  shares of Common Stock, Class A Preferred Stock ,Class
C Series 4 Preferred Stock and Class C Series 5 Preferred Stock,  represented in
person or by proxy at the Annual Meeting,  will constitute a quorum. If a quorum
is present and any votes are cast in favor of the nominees, they will be elected
directors of the Corporation. Accordingly, abstentions and broker non-votes will
not affect the outcome of the election. All other matters to be voted on will be
decided  by the  affirmative  vote  of a  majority  of  the  Shares  present  or
represented  at the  Meeting  and  entitled  to  vote.  On any such  matter,  an
abstention  will have the same  effect as a  negative  vote and  Shares  held by
brokers  will not be  considered  entitled  to vote on  matters  as to which the
brokers have not received authority to vote from beneficial owners.

         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

     The following table sets forth certain information regarding the beneficial
ownership of the total voting stock  (including the Common Stock and the Class A
Preferred  Stock)  as of June 14,  2000 by:  (i) each  Stockholder  known by the
Corporation to  beneficially  own in excess of 5% of the  outstanding  shares of
Common  Stock,  Class A Preferred  Stock,  Class C Series 4 Preferred  Stock and
Class C Series 5 Preferred Stock; (ii) each director and director  nominee;  and
(iii) all directors,  director nominees and executive officers,  as a group. All
of the  outstanding  Class A Preferred  Stock is owned by Dr.  Ramesh C. Pandey.
Except as otherwise  indicated in the footnotes to the table,  the persons named
below  have  sole  voting  and  investment  power  with  respect  to the  shares
beneficially owned by such persons.

<TABLE>
<CAPTION>
-------------------------------------------------------------------------------------------------------------------------------
                                                        CLASS A PREFERRED             CLASS C PREFERRED
                            COMMON STOCK                      STOCK                         STOCK
-------------------------------------------------------------------------------------------------------------------------------
                       NUMBER OF      PERCENT        NUMBER OF      PERCENT        NUMBER OF      PERCENT         PERCENT OF
NAME AND ADDRESS        SHARES        OF CLASS        SHARES        OF CLASS        SHARES        OF CLASS     VOTING STOCK (1)
-------------------------------------------------------------------------------------------------------------------------------
<S>                    <C>               <C>             <C>            <C>       <C>                  <C>           <C>
The Edward A. Blech    72,300,000        30.1%               0             -                0            -           22.2%
Trust (2)                     (3)
-------------------------------------------------------------------------------------------------------------------------------
David Blech (4)        83,284,495        34.6%               0             -                0            -           25.6%
                       (3)(5)(15)
-------------------------------------------------------------------------------------------------------------------------------
Michael G. Jesselson   15,050,000         6.3%               0             -                0            -            4.6%
(6)                        (7)(8)
-------------------------------------------------------------------------------------------------------------------------------
Jay Gupta (9)          20,000,000         8.3%               0             -      100,000(12)          50%           18.4%
-------------------------------------------------------------------------------------------------------------------------------
Stephen Burg (13)       1,500,000          .6%               0             -                0            -             .5%
-------------------------------------------------------------------------------------------------------------------------------
Dr. Ramesh C. Pandey   22,164,545         9.2%           2,500          100%          100,000          50%           20.6%
(10)                     (11)(15)                                                        (14)
-------------------------------------------------------------------------------------------------------------------------------
All directors and      23,664,545         9.8%           2,500          100%          100,000          50%           21.0%
executive officers as        (11)                                                        (14)
a group (2 persons)
-------------------------------------------------------------------------------------------------------------------------------
</TABLE>

     (1)  Gives  effect to the voting  rights of 2,500  shares of Class A Voting
          Preferred  Stock,  all of which  are  owned by Dr.  Pandey  and  which
          entitle  him to cast 1,000  votes per share on all matters as to which
          shareholders are entitled to vote.

     (2)  The  address of The Edward A. Blech  Trust is 418 Avenue I,  Brooklyn,
          New York 11230.

     (3)  As  reported  in a Schedule  13D filed  jointly  by Mr.  Blech and the
          Trust.

     (4)  The address of Mr. Blech is 445 West 23rd Street,  #16E, New York, New
          York 10011.

     (5)  Includes shares owned by the Trust, shares owned by Mr. Blech's spouse
          and shares held by Mr. Blech as custodian for a minor child.

     (6)  The address of Michael Jesselson is 1301 Avenue of the America,  Suite
          4101, New York, New York 10019.

<PAGE>

     (7)  As reported in a Form 3.

     (8)  Includes shares owned by the Michael G. Jesselson  12/18/80 Trust, the
          Benjamin J. Jesselson  12/18/80 Trust and the Jesselson  Grandchildren
          12/18/80 Trust .

     (9)  The address of Jay Gupta is 1173 Dolly Madison Blvd., McLean, Virginia
          22101.

     (10) The  address of Dr.  Pandey is c/o  Xechem  International,  Inc.,  100
          Jersey Avenue, Building B, Suite 310, New Brunswick, New Jersey 08901.

     (11) Does not include  707,000 shares  subject to certain  options owned by
          Dr.  Pandey,  which  presently  are not  exercisable,  and will not be
          exercisable, within 60 days from June 14, 2000.

     (12) Gives effect to the voting rights of 100,000  shares of Class C Series
          4  Preferred  Stock,  all of which  are  owned by Jay  Gupta and which
          entitle  him to cast 400 votes per  share on all  matters  as to which
          shareholders are entitled to vote.

     (13) The address of Stephen  Burg is 3257  Winged  Foot  Drive,  Fairfield,
          California 94533.

     (14) Gives effect to the voting rights of 100,000  shares of Class C Series
          5  Preferred  Stock,  all of which are owned by Dr.  Pandey  and which
          entitles  him to cast  422.59318  votes per share on all matters as to
          which shareholders are entitled to vote.

     (15) During  1999,  Blech,  his wife and the trustee of the Edward A. Blech
          Trust  granted to Dr. Pandey an  irrevocable  proxy to vote all of the
          shares under their control.  These proxies relate to 83,284,495 shares
          of  Company  Common  Stock or  approximately  34.6%  of the  Company's
          presently outstanding shares of Common Stock.

*    Less than one percent.

                    MATTERS TO BE CONSIDERED BY STOCKHOLDERS

1.   ELECTION OF DIRECTORS

     Two individuals will be elected at the Annual Meeting to serve as directors
of the Corporation until the next annual meeting of stockholders or otherwise as
provided in the By-Laws.  Unless  instructions  to the  contrary are given,  the
persons named as proxy voters in the accompanying  proxy, or their  substitutes,
will vote for the following  nominees for directors  with respect to all proxies
received by the  Corporation.  If any of the nominees should become  unavailable
for any reason,  the votes will be cast for a substitute  nominee  designated by
the Board.  The board of  directors  have no reason to believe that the nominees
named will be unable to serve, if elected.

     The nominees for director are as follows:

     Ramesh C. Pandey, Ph.D., age 61, is the founder of the Corporation.  He has
been Chief Executive  Officer and President and a director of the  Corporation's
subsidiary, Xechem, Inc. (the "Subsidiary"), since its formation in 1990 and the
Chief Executive  Officer,  President,  and Chairman of the Board of Directors of
the  Corporation  since its formation in February 1994. From 1984 to March 1990,
Dr.  Pandey  was  the  President  and  Chief  Scientist  of  the   Corporation's
predecessor,  Xechem Inc., formerly a subsidiary of Fujisawa/LyphoMed,  Inc. Dr.
Pandey served as a visiting  Professor at the Waksman  Institute of Microbiology
at  Rutgers  University  from  1984 to  1986.  Dr.  Pandey  has also  served  as
scientist,  consultant,  and research  associate  for several  universities  and
private laboratories. Dr. Pandey has published numerous articles in professional
publications,  such as the Journal of  Antibiotics,  the Journal of the American
Chemical  Society and the Journal of  Industrial  Microbiology.  Dr. Pandey is a
member of the  editorial  board of the  Journal  of  Antibiotics  and of several
professional societies.

     Stephen F. Burg, age 62, since 1986 has been chief executive  officer of El
Dorado  Investments,  which offers  corporate  growth  strategies for public and
private companies,  nationally and internationally.  From 1978 to 1986, Mr. Burg
was Vice  President-Corporate  Acquisitions  for Evans Products Company and from
1973 to 1978 was  Corporate  Director-Acquisitions  and Human  Services for Jack
August Enterprises.

<PAGE>

     The  Corporation's  By-Laws  do not  require  that the  directors  meet any
specific  number of times during the year.  Such  meetings may be held either in
person or by  telephonic  conference.  The Board met three times during the year
ended December 31, 1999.

     The Board has an audit committee  presently  consisting of Dr. Pandey which
was formed on May 26, 1995. The audit committee  reviews with the  Corporation's
independent  public accountants the scope and timing of their audit services and
any other  services they are asked to perform,  the  accountants'  report on the
Corporation's  financial  statements following completion of their audit and the
Corporation's  policies and procedures  with respect to internal  accounting and
financial   controls.   In   addition,   the  audit   committee   makes   annual
recommendations to the Board for the appointment of independent  accountants for
the ensuing year.

     The audit committee did not meet during the year ended December 31, 1999.

     The Board has a stock option committee  presently  consisting of Dr. Pandey
which was formed on May 26, 1995.  The stock option  committee  administers  the
Xechem  International,  Inc. Amended and Restated Stock Option Plan (the "Plan")
and reviews and recommends to the Board stock options to be granted.

     The stock option  committee did not meet during the year ended December 31,
1999.

     The Board has a compensation  committee presently  consisting of Dr. Pandey
which  was  formed on May 26,  1995.  The  compensation  committee  reviews  and
recommends  to the Board the  compensation  and  benefits of all officers of the
Corporation  and reviews  general policy matters  relating to  compensation  and
benefits of employees of the Corporation.

     Since Dr. Pandey's salary is fixed by contract and he is the  Corporation's
only executive officer, the Compensation  Committee did not meet during the year
ended December 31, 1999.

     Section 16(a) of the Securities Exchange Act of 1934, as amended,  requires
the  Corporation's  officers  and  directors,  and persons who own more than ten
percent of a registered class of the Corporation's  equity  securities,  to file
initial  statements of beneficial  ownership (Form 3), and statements of changes
in  beneficial  ownership  (Forms 4 or 5),  of Common  Stock  and  other  equity
securities of the Corporation with the U.S.  Securities and Exchange  Commission
(the "SEC"). The SEC requires  officers,  directors and greater than ten percent
stockholders  to furnish  the  Corporation  with copies of all these forms filed
with the SEC.

     To the Corporation's knowledge, based solely on its review of the copies of
these forms received by it, or written  representations  from certain  reporting
persons  that  no  additional  forms  were  required  for  those  persons,   the
Corporation believes that its officers,  director,  and greater than ten percent
beneficial owners have complied with all filing requirements.

     RECOMMENDATION  OF THE BOARD: The Board hereby recommends and nominates Dr.
Pandey  and Mr.  Burg  for  election  as  directors  of the  Corporation  by the
Stockholders  at the Annual  Meeting to serve until the next  annual  meeting of
stockholders or as otherwise provided in the By-Laws.

     The two  nominees  receiving  the  highest  vote  totals  will  be  elected
directors of the Corporation. Accordingly, abstentions and broker non-votes will
not affect the outcome of the election.

2.   APPROVAL OF AN AMENDMENT TO THE CORPORATION'S  CERTIFICATE OF INCORPORATION
     TO INCREASE  THE  AUTHORIZED  NUMBER OF SHARES FROM  250,000,000  SHARES TO
     750,000,000  SHARES  CONSISTING OF  700,000,000  SHARES OF COMMON STOCK AND
     50,000,000 SHARES OF PREFERRED STOCK.

<PAGE>

     The   Corporation  is  proposing  this  amendment  to  its  Certificate  of
Incorporation  to allow the Corporation to have available  sufficient  shares of
Common Stock for issuance in connection with the exercise of outstanding options
(the  "Options") and warrants (the  "Warrants") to purchase Common Shares of the
Corporation and in connection with obtaining additional capital. The Certificate
of Incorporation presently authorizes the Corporation to issue up to 250,000,000
shares consisting of 247,000,000  shares of Common Stock and 3,000,000 shares of
Preferred Stock. If this Resolution is adopted, 500,000,000 additional shares of
Common Stock and Preferred  Stock will be available for issuance by the Board of
Directors without any requirement of further Stockholder  approval.  In addition
to the  Common  Stock the  Corporation  expects to issue  upon  exercise  of the
Options and the Warrants, the Corporation may issue additional shares to provide
additional funds for working capital and acquisitions of other  businesses.  The
Corporation  has under active  consideration  a possible  issuance of additional
Common  Stock in an offering  either  registered  pursuant to or exempt from the
registration requirements of federal and applicable state securities laws. It is
possible,  although the Corporation cannot guarantee,  that the amount of Common
Stock  that the  Company  may issue in such  offering  may  exceed the number of
shares of Common Stock presently authorized under the Corporation's  Certificate
of  Incorporation.  The  Board  of  Directors  believes  it  desirable  that the
Corporation have the flexibility to be able to issue  additional  shares without
Stockholder  approval.  Stockholders  have no preemptive  rights to purchase any
shares. The Corporation may issue additional Shares at such times and under such
circumstances  as to have a  dilutive  effect on  earnings  per share and on the
equity ownership of present Stockholders.

     RECOMMENDATION   OF  THE  BOARD:  The  Board  hereby  recommends  that  the
Stockholder's  concur in the following  resolution which will be presented for a
vote of the Stockholders at the Annual Meeting:

     RESOLVED, that the Corporation's Certificate of Incorporation be amended to
increase the number of authorized shares from 250,000,000 to 750,000,000  shares
consisting  of  700,000,000  shares of Common  Stock  and  50,000,000  shares of
Preferred Stock.

     The  affirmative  vote for a  majority  of the votes  cast by  Stockholders
present  in person or by proxy and  eligible  to vote at the  Meeting,  a quorum
being present, is required for the adoption of the foregoing resolution.

3.   APPROVAL OF AN  INCREASE IN THE NUMBER OF SHARES OF COMMON  STOCK WHICH MAY
     BE ISSUED UNDER THE XECHEM  INTERNATIONAL,  INC. AMENDED AND RESTATED STOCK
     OPTION PLAN

     The Plan amends the Xechem  International,  Inc. Amended and Restated Stock
Option Plan, the obligations under which the Corporation  assumed as part of the
Corporation's  organization and prior to its April 26, 1994 public offering. The
purpose  of  the  Plan  is  to  encourage  ownership  of  Common  Stock  by  the
Corporation's  key  employees,  non-employee  directors and advisors,  including
members of the Company's  Scientific  Adversary  Board, in order to attract such
persons,  to induce such persons to remain in the employ of the  Corporation  or
its  affiliates,  or to serve as an advisor to the  Corporation,  and to provide
additional  compensation  for  such  persons  to  promote  the  success  of  the
Corporation  or its  affiliates.  Key employees  include  employees who are also
officers or directors of the Corporation or its affiliates.

     The decision to grant  options to these  individuals  is intended to reward
them for their services to the  Corporation  without  burdening the  Corporation
with  significant  increases in direct  compensation.  Since its inception,  the
Corporation's  directors,  key employees and advisors have been  endeavoring  to
reach the Corporation's objectives of developing a more efficient drug discovery
process and niche generic drugs, as well as  commercializing  and marketing such
drugs. Through their efforts, the Corporation believes that significant progress
has been made toward these objectives. The Board believes

<PAGE>

that the ability to achieve these  objectives is best served by the alignment of
the financial success of the Corporation's directors and key employees with that
of its Stockholders.

     Stockholder approval of this amendment to the Plan is sought to continue to
qualify the Plan under Rule 16b-3 of the  Securities  Exchange  Act of 1934,  as
amended (the "Exchange Act"), and thereby render certain  transactions under the
Plan exempt from certain provisions of Section 16 of the Exchange Act.

     As of the date of this Proxy Statement, the Company has granted options for
1,598,000  shares of Common Stock  available  for issuance  under the Plan.  The
Board has  authorized  an  increase  of  12,400,000  shares of Common  Stock for
issuance  under the Plan, for a total of 25,000,000  shares.  The Board believes
that it is in the best  interests of the  Corporation  and the  Stockholders  to
increase the number of shares of Common Stock which may be issued under the Plan
in order to continue to attract key persons to the  Corporation  and reward them
for their  efforts.  With the  exception of  increasing  the number of shares of
Common  Stock  which may be issued  under  the  Plan,  the Board is not  seeking
Stockholder approval of any other provisions of the Plan.  Therefore,  the Board
recommends that the Stockholders vote to increase the number of shares of Common
Stock which may be issued under the Plan.

General
-------

     The Plan  grants the Board  authority  to issue  options to  purchase up to
12,600,000 shares (to be increased to 25,000,000 shares) of Common Stock and any
other stock or security resulting from adjustments or substitutions as described
in the Plan.  The Common Stock will be reserved and  available for purchase upon
the exercise of options granted under the Plan.

     The Plan  provides for the issuance of incentive  options under Section 422
of the Internal Revenue Code of 1986, as amended (the "Code"),  and nonstatutory
options  which are not intended to be incentive  stock options under Section 422
of the Code.  The  decision  as to whether  incentive  options  or  nonstatutory
options will be issued to  recipients  is solely  within the  discretion  of the
Board.  The Board will  administer the Plan and have the authority to determine,
among  other  things,  the  individuals  to  be  granted  incentive  options  or
nonstatutory  options,  the  exercise  price at which  the  Common  Stock may be
acquired, the number of shares subject to each option and the exercise period of
each option.  The Board will also be  authorized  to construe and  interpret the
Plan and to  prescribe  additional  terms and  conditions  of exercise in option
agreements  and provide  the form of option  agreement  to be utilized  with the
Plan.

     Incentive options terminate not more than ten years from the date of grant;
however,  such options terminate not more than five years from the date of grant
if such options are required to have an exercise  price of at least 110% of fair
market value. Nonstatutory options terminate not more than eleven years from the
date of grant.

     Options will not be  transferable  except by will or by the laws of descent
and distribution,  and are exercisable during an optionee's lifetime only by the
optionee or the appointed guardian or legal representative of the optionee. Upon
the  (i)  death  or  permanent  and  total  disability  of an  optionee  or (ii)
termination  of  employment  with the  Corporation  any  unexercised  options to
acquire  Common Stock will be  exercisable  at any time within six months in the
case  of (i)  and 30 days in the  case  of  (ii)  (but  in no  case  beyond  the
expiration date specified in the option agreement).

     The Plan  requires the  optionee to pay, at the time of  exercise,  for all
shares   acquired  on  exercise  in  cash,   Common  Stock  or  other  forms  of
consideration acceptable to the Board.

     If the Corporation declares a stock dividend, splits its stock, combines or
exchanges its Common Stock, or engages in any other transactions which result in
a change in capital structure, such as a merger,

<PAGE>

consolidation,  dissolution,  liquidation or similar transaction,  the Board may
adjust or  substitute,  as the case may be, the number of shares of Common Stock
available  for issuance upon  exercise of options  granted  under the Plan,  the
number of shares covered by outstanding options, the exercise price per share of
outstanding  options, any target price levels for vesting of the options and any
other  characteristics  of the options as the Board deems necessary to equitably
reflect the effects of those changes on the option holders.

     The  Corporation  has granted  options for a total of  1,598,000  shares of
Common  Stock  under the Plan.  Included  in the count are  options to  purchase
318,500  shares  of  Common  Stock  granted  to  former  directors  and a former
executive  officer of the Corporation and options to purchase  764,000 shares of
Common Stock granted to other employees of the Corporation.

     Pursuant to the terms of the grants,  the options for shares  granted under
the Plan vest and are exercisable in installments as follows:  (i) to the extent
of 20% of the  number  of  shares  of  Common  Stock,  commencing  on the  first
anniversary  of the date of grant;  and (ii) to the remaining 80% of shares,  an
additional 20% commencing on each of the second through the fifth anniversary of
the date of grant.

Discussion of Federal Income Tax Consequences
---------------------------------------------

     The following summary of tax consequences is not comprehensive and is based
on laws and  regulations in effect on June 1, 1998.  These laws and  regulations
are subject to change on a retroactive basis.

     The grant of a  nonqualified  option under the Plan is not a taxable  event
and the  Corporation  is not  entitled  to a  deduction  upon such  grant.  Upon
exercise of a nonqualified option, participants will be taxed at ordinary income
rates on the  difference  between the exercise  price of the option and the fair
market value of the Common Stock issued  pursuant to such exercise.  Fair market
value generally will be determined on the date of exercise (or in the case where
a sale of property could subject a transferor to suit under Section 16(b) of the
Securities  Exchange Act of 1934, the later of the date of exercise and the date
which is six months and one day after the date on which the option was  granted,
unless the participant  elects to be taxed based on the fair market value at the
date of exercise).  The Corporation  will receive a corresponding  deduction for
the amount of income  recognized by a participant  upon exercise of an option in
the same year the participant  recognizes income in connection with the exercise
of an option. The participant,  generally,  will have a tax basis for the Common
Stock acquired equal to the fair market value of the Common Stock at the date of
exercise. Any gain or loss realized upon the subsequent sale of the Common Stock
issued upon exercise of a nonqualified  option will be taxed at either long-term
or  short-term   capital  gain  (or  loss)  rates,   depending  on  the  selling
stockholder's holding period. The subsequent sale would have no tax consequences
for the Corporation.

     The recipient of an incentive stock option generally will not recognize any
income upon its grant or upon its exercise if no disposition of the Common Stock
received upon exercise is made within two years from the date of grant or within
one year  after the  acquisition  of the  Common  Stock.  The excess of the fair
market  value of the Common  Stock over the  exercise  price of the Common Stock
received  upon the  exercise of an incentive  stock  option,  however,  is a tax
preference  item in the year of exercise  which may subject the  recipient to an
alternative  minimum  tax.  Upon a  subsequent  sale of  Common  Stock  acquired
pursuant to exercise of an incentive  stock  option,  if the  foregoing  holding
periods are met, the recipient will recognize a long-term  capital gain upon the
difference  between the sale price and the exercise  price,  and the Corporation
will receive no deduction from taxable income.  If these holding periods are not
met, the recipient  generally will realize  ordinary income to the extent of the
difference  between the  exercise  price and the fair market value of the Common
Stock on the date the option is exercised.  However,  if the disposition is by a
sale or exchange at a price less than the fair market  value of the Common Stock
on the date of  exercise,  then,  in general,  the amount of ordinary  income is
limited  to the gain  recognized  on such sale or  exchange.  If the sale  price
exceeds the fair market value of the

<PAGE>

Common  Stock  on the date of  exercise,  such  excess  will be a  long-term  or
short-term  capital gain,  depending on the  employee's  holding  period for the
Common  Stock being sold.  The  Corporation  will have a deduction  in an amount
equal to the ordinary income recognized by the optionee.

     RECOMMENDATION  OF THE BOARD:  The Board  recommends that the  Stockholders
concur in the  following  resolution  which will be presented  for a vote of the
Stockholders at the Annual Meeting:

          RESOLVED,  that the Xechem  International,  Inc.  Amended and Restated
     Stock  Option  Plan be amended to  increase  the number of shares of Common
     Stock  which  may be issued  under  such  plan  from  12,600,000  shares to
     25,000,000 shares.

     The  affirmative  vote of a  majority  of the  votes  cast by  Stockholders
present  in person or by proxy and  eligible  to vote at the  Meeting,  a quorum
being present, is required for the adoption of the foregoing resolution.

                COMPENSATION OF DIRECTORS AND EXECUTIVE OFFICERS

A.   DIRECTOR COMPENSATION

     Directors serve without compensation for such services.

B.   EXECUTIVE COMPENSATION

     Set forth below is information  concerning the  compensation for 1997, 1998
and 1999 for the Corporation's President and Chief Executive Officer, who is the
only executive officer of the Corporation whose  compensation  exceeded $100,000
during such years:

<TABLE>
<CAPTION>
==============================================================================================================================
                                                                                 LONG TERM COMPENSATION
                                                                                                                     ALL OTHER
                                          ANNUAL COMPENSATION                                                     COMPENSATION
------------------------------------------------------------------------------------------------------------------------------
                                                                                   AWARDS                PAYOUTS
------------------------------------------------------------------------------------------------------------------------------
                                                                                                        LONG TERM
                                                            OTHER         RESTRICTED    SECURITIES      INCENTIVE
                                                            ANNUAL           STOCK      UNDER-LYING        PLAN
YEAR                              SALARY       BONUS     COMPENSATION       AWARDS        OPTIONS        PAYOUTS
------------------------------------------------------------------------------------------------------------------------------
<S>                             <C>                 <C>     <C>           <C>                    <C>           <C>           <C>
Dr. Ramesh Pandey 1997          $  130,273          0       $    7,991             0             0             0             0
         1998                   $  136,233          0       $    7,340             0             0             0             0
         1999                   $  140,000          0       $    1,249    $1,563,000             0             0             0
==============================================================================================================================
</TABLE>

<PAGE>

EMPLOYMENT AGREEMENTS.
---------------------

     Ramesh C. Pandey is employed  pursuant to an agreement which provides for a
base salary of $140,000 per year, subject to an annual increase in proportion to
the  increase in the  consumer  price  index,  such bonuses as a majority of the
disinterested members of the Board of Directors may determine,  and a royalty of
2 1/2% of the  Corporation's  net  profits  before  taxes  with  respect  to any
products  developed by the Corporation or its affiliates  during the term of the
agreement.  The royalty  will be payable to Dr.  Pandey or his estate so long as
the Corporation continues to sell such products, notwithstanding any termination
of the agreement. The agreement provides for a ten year term, but permits either
party to terminate the agreement after five years; if the Corporation terminates
the  agreement,  Dr. Pandey will be entitled to receive  severance  equal to his
compensation  for the two years prior to termination.  Dr. Pandey has agreed not
to engage in certain business  activities  (generally similar to those currently
engaged in by the  Corporation)  for six months (four months,  in certain cases)
after the  termination of his  employment  with the  Corporation.  If there is a
change in the beneficial ownership of 20% or more of Xechem's capital stock, Dr.
Pandey  may,  at any time  within  one year  after  such  event,  terminate  the
agreement, in which event his noncompete and confidentiality agreement terminate
and all  indebtedness  of the  Corporation to Dr. Pandey shall  accelerate.  Dr.
Pandey  has agreed  and  approved  the  transactions  contemplated  by the Blech
Purchase Agreement (see "Certain  Relationships and Related  Transactions") and,
accordingly,  such  transactions  do not and will not  result  in a  "Change  of
Control" as defined in the  Employment  Agreement.  In August  1996,  due to the
financial constraints of the Company, Dr. Pandey's salary was reduced by 54%. In
November  1996,  50% of the  reduction  was restored and in February  1997,  Dr.
Pandey was returned to full salary.  In 1998, Dr. Pandey's salary was reduced by
50% and the reduction has been accrued each year since.

STOCK PLAN

     Effective  December  1993,  Xechem's  sole  stockholder  approved the Share
Option Plan (the "Plan"),  which the Corporation has assumed,  providing for the
issuance to employees,  consultants,  and directors of options to purchase up to
2,600,000  shares of Common  Stock,  which  number of shares  will  increase  to
25,000,000  shares  if the  Stockholders  approve  Resolution  No.  2.  The Plan
provides  for the grant to employees of  incentive  stock  options  ("ISOs") and
non-qualified stock options.

     The Plan is  administered  by a Stock Option  Committee  established in May
1995  comprised of two members of the Board of Directors  which has the power to
determine  eligibility to receive options and the terms of any options  granted,
including the exercise or purchase  price,  the number of shares  subject to the
options,  the vesting schedule,  and the exercise period.  The exercise price of
all ISOs granted  under the Plan must be at least equal to the fair market value
of the  shares  of  Common  Stock  on the date of  grant.  With  respect  to any
participant  who owns stock  possessing more than 10% of the voting power of the
Corporation's  outstanding  capital stock, the exercise price of any ISO granted
must  equal at least  110% of the fair  market  value on the grant  date and the
maximum  exercise  period of the ISO must not exceed  five years.  The  exercise
period of any other  options  granted under the Plan may not exceed 11 years (10
years in the case of ISOs).

     The Plan will  terminate in December  2003, ten years after the date it was
first approved by the  Corporation's  stockholders,  though awards made prior to
termination  may expire after that date,  depending on when granted.  As of June
14,  2000,  the  Corporation  has  granted  options  under the Plan to  purchase
1,598,000 shares of Common Stock.

AGGREGATED OPTION EXERCISES IN FISCAL 1999 AND FISCAL YEAR-END OPTION VALUES

     The following  table provides  information on option  exercises  during the
year ended  December 31, 1999 by the  Corporation's  present  directors  and the
value of such party's unexercised options as of December 31, 1999:

<TABLE>
<CAPTION>
-------------------------------------------------------------------------------------------------------------
                                                       Number of Securities          Value of Unexercised
                                                      Underlying Unexercised         In-the-Money Options
                                                        Options at 12/31/99             at 12/31/99 (1)
-------------------------------------------------------------------------------------------------------------
                           Share
                          Acquired    Value
                        on Exercise  Realized    Exercisable    Unexercisable    Exercisable    Unexercisable
-------------------------------------------------------------------------------------------------------------
        Name                (#)        ($)
-------------------------------------------------------------------------------------------------------------
<S>                               <C>       <C>       <C>             <C>            <C>              <C>
Dr. Ramesh C. Pandey              0         0              0          707,000(2)           0          $35,343
-------------------------------------------------------------------------------------------------------------
Stephen Burg                      0         0         40,000           25,000         $1,600          $ 1,000
-------------------------------------------------------------------------------------------------------------
</TABLE>

(1)  Represents the excess,  if any, of the closing price of the Common Stock as
     quoted on the OTC  Bulletin  Board on  December  31,  1999 ($.05 ) over the
     exercise price of the options,  multiplied by the  corresponding  number of
     underlying shares.

(2)  These  options  were  issued in exchange  for the capital  stock of Xechem,
     Inc., a wholly owned subsidiary of the Company,  in the  reorganization  of
     the  Company.  These  options are  exercisable  upon the Company  attaining
     specific financial goals.

                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

     Subject to obtaining  necessary  regulatory  approvals in India, Dr. Pandey
has transferred his interest in Xechem India to the Company for no consideration
other than  reimbursement of amounts (equal to approximately  $5,000) Dr. Pandey
advanced for  organizational  expenses.  Dr. Pandey's brothers own the remaining
equity in Xechem  India,  some or all of which the Company  anticipates  will be
made  available  to other,  unrelated,  persons in India.  Both of Dr.  Pandey's
brothers  and Mr. Anil  Sharma,  a chartered  accountant,  serve as directors of
Xechem India. No  compensation is paid to Dr. Pandey,  his relatives or Mr. Anil
Sharma for service as directors.

     Effective June 25, 1996, an entity wholly-owned by Dr. Pandey (the "Holding
Company") became a member of Vineyard Productions, L.L.C. ("Vineyard"), which in
June 1994 acquired the building in which the Company  leases its offices.  Prior
to making such  investment,  Dr.  Pandey  informed the Board of Directors of the
opportunity for such  investment,  and the Board determined that the Company was
not  interested  in  such   opportunity  and  approved  Dr.  Pandey  making  the
investment.  The  Company's  lease was  entered  into prior to that date (with a
prior owner of the building) and has not been modified subsequent  thereto.  The
Company paid Vineyard $60,606 in 1998 and $143,847 in 1999.

     In 1999,  David Blech and Dr.  Pandey  agreed to amend those  portions of a
stockholder agreement as to which they are parties.  Specifically, Mr. Blech and
Dr. Pandey have amended this agreement to: (i) eliminate the prohibition against
Dr.  Pandey's sale of any shares of Company  capital stock for five years except
with Blech's  consent;  (ii)  eliminate  Mr.  Blech's right to sell his pro rata
portion(relative  to the holdings of Dr.  Pandey) of any proposed sale of shares
by Dr.  Pandey,  and a reciprocal  right in favor of Dr.  Pandey to sell his pro
rata portion of any shares sold by Mr. Blech;  (iii)  eliminate the  requirement
that Mr. Blech vote for Dr. Pandey as a director of the Company,  and to use his
best  efforts  to cause  Dr.  Pandey  to  remain  Chairman  President  and Chief
Executive  Officer of the Company;  and (iv) eliminate the requirement  that the
Company and its  directors(subject  to their fiduciary duties to the Company and
the  shareholders  of the Company) to take such actions as Mr. Blech may request
to elect his nominees to constitute a majority of the directors of the Company.

     Also  during  1999,  Mr.  Blech,  his wife and the trustee of the Edward A.
Blech Trust granted to Dr. Pandey an irrevocable proxy to vote all of the shares
under their control. These proxies relate to 83,284,495 shares of Company Common
Stock or approximately  34.6% of the Company's  presently  outstanding shares of
Common Stock.

     During 1997 and 1998, the Company made unsecured loans totaling $100,000 to
Consumers Choice Systems,  Inc. ("CCS"),  a company engaged in the marketing and
distribution  of products in the  over-the-counter  pharmaceutical  market.  The
Company has entered into negotiations with CCS in connection with

<PAGE>

possible distribution of XetaPharm  nutraceuticals.  CCS is engaged in a private
offering of its securities  and, upon  completion of this  offering,  The Edward
Blech Trust would own  approximately  30.8% of CCS's common  stock.  In 1999 the
balance of these loans was deemed uncollectable and written off.

     During 1998, the Company made six unsecured  loans in the amount of $72,000
to Pacific Sensuals,  Inc.  ("Pacific"),  a company engaged in the marketing and
distribution  of products sold through  health  stores.  The Company has entered
into  negotiations  with Pacific in  connection  with possible  distribution  of
XetaPharm nutraceuticals.  David Blech has an indirect 38% ownership interest in
Pacific.  During 1997 and 1998,  the  Company  made six  unsecured  loans in the
amount of  $144,000  to  Margaret  Chassman.  Ms.  Chassman is the wife of David
Blech.

                              STOCKHOLDER PROPOSALS

     Stockholder  proposals for the 2000 Annual Meeting of Stockholders  must be
received  by the  Corporation  at its  executive  office in New  Brunswick,  New
Jersey,  on or prior to February  14, 2001 for  inclusion  in the  Corporation's
proxy statement for that meeting.  Any  stockholder  proposal must also meet the
other  requirements  for stockholder  proposals as set forth in the rules of the
U.S. Securities and Exchange Commission relating to stockholder proposals.

                                  OTHER MATTERS

     As of the date of this  Proxy  Statement,  no  business,  other  than  that
discussed above, is to be acted upon at the Meeting.  If other matters not known
to the Board  should,  however,  properly  come before the Meeting,  the persons
appointed by the signed proxy  intend to vote it in  accordance  with their best
judgment.


                                        Xechem International, Inc.
                                        By the Order of the Board of Directors


                                        Ramesh C. Pandey, Ph.D.
                                        President and Chief Executive Officer

New Brunswick, New Jersey
June 22, 2000

     A COPY OF THE XECHEM INTERNATIONAL,  INC. 1999 ANNUAL REPORT ON FORM 10-KSB
FILED WITH THE U.S.  SECURITIES  AND  EXCHANGE  COMMISSION  WILL BE  SUPPLIED TO
STOCKHOLDERS WITHOUT CHARGE. REQUESTS FOR THE REPORT SHOULD BE DIRECTED TO:

          Xechem International, Inc.
          100 Jersey Avenue, Building B, Suite 310
          New Brunswick, New Jersey  08901-3279

        =================================================================

                  YOUR VOTE IS IMPORTANT. THE PROMPT RETURN OF
                PROXIES WILL SAVE THE CORPORATION THE EXPENSE OF
                  FURTHER REQUESTS FOR PROXIES. PLEASE PROMPTLY
                 MARK, SIGN, DATE AND RETURN THE ENCLOSED PROXY
                            IN THE ENCLOSED ENVELOPE.
        =================================================================


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