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EXHIBIT 16 December 19, 2000 Securities and Exchange Commission 450 Fifth Street, N.W. Washington, D.C. 20549 Gentlemen: We have read the statements made by Xechem International, Inc. which we understand will be filed with the Commission, pursuant to Item 4 of the Company's Form 8-K report during the month of December 2000. We agree with the statements concerning our firm in such Form 8-K. Very truly yours, /s/ Wiss and Company, LLP WISS AND COMPANY, LLP
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