XECHEM INTERNATIONAL INC
8-K/A, EX-16, 2000-12-19
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                   EXHIBIT 16

                                December 19, 2000

Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549

Gentlemen:

We have  read  the  statements  made by  Xechem  International,  Inc.  which  we
understand  will  be  filed  with  the  Commission,  pursuant  to  Item 4 of the
Company's Form 8-K report during the month of December 2000.

We agree with the statements concerning our firm in such Form 8-K.

                                        Very truly yours,

                                        /s/ Wiss and Company, LLP

                                        WISS AND COMPANY, LLP



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