QUINTILES TRANSNATIONAL CORP
S-8, 1997-11-18
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1

     As filed with the Securities Exchange Commission on November 18, 1997

                                                     Registration No. 333-
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 ---------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                          QUINTILES TRANSNATIONAL CORP.
             (Exact name of registrant as specified in its charter)

North Carolina                                                   56-1714315
(State or other jurisdiction of                               (I.R.S. Employer
incorporation or organization)                               Identification No.)


4709 Creekstone Drive,
Riverbirch Building, Suite 300
Durham, North Carolina                                              27703-8411
(Address of Principal Executive Offices)                            (Zip Code)

                 ACTION INTERNATIONAL MARKETING SERVICES LIMITED
                         NONQUALIFIED STOCK OPTION PLAN
          QUINTILES TRANSNATIONAL CORP. NONQUALIFIED STOCK OPTION PLAN
      PROFESSIONAL PHARMACEUTICAL MARKETING SERVICES (PROPRIETARY) LIMITED
                         NONQUALIFIED STOCK OPTION PLAN
                            (Full title of the plans)

                            Dennis B. Gillings, Ph.D.
                Chairman of the Board and Chief Executive Officer
                          Quintiles Transnational Corp.
              4709 Creekstone Drive, Riverbirch Building, Suite 300
                        Durham, North Carolina 27703-8411
                     (Name and address of agent for service)

                                 (919) 941-2000
          (Telephone number, including area code, of agent for service)

                                    Copy to:
                              Gerald F. Roach, Esq.
                               Amy J. Meyers, Esq.
          SMITH, ANDERSON, BLOUNT, DORSETT, MITCHELL & JERNIGAN, L.L.P.
                              Post Office Box 2611
                       Raleigh, North Carolina 27602-2611
                                 (919) 821-1220

                         CALCULATION OF REGISTRATION FEE
<TABLE>
<S>                           <C>               <C>                   <C>                  <C>
- ------------------------------------------------------------------------------------------------------------
Title of securities           Amount to be       Proposed maximum      Proposed maximum        Amount of
to be registered              registered(1)     offering price per    aggregate offering    Registration fee
                                                    share(2)                price
- ------------------------------------------------------------------------------------------------------------
Common Stock, par value        1,347,097            $73.633             $99,190,793.40         $30,057.82
$.01 per share                   shares
- ------------------------------------------------------------------------------------------------------------
</TABLE>


(1)      Plus such indeterminate number of shares as may be issued pursuant to
         certain anti-dilution provisions contained in the plans.

(2)      Pursuant to Rule 457(c) and (h), based upon the average of the high and
         low prices for the Company's Common Stock reported on the Nasdaq Stock
         Market on November 12, 1997.


<PAGE>   2



                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

                                EXPLANATORY NOTE

         As permitted by the rules of the Securities and Exchange Commission
(the "Commission"), this registration statement omits the information specified
in Part I (Items 1 and 2) of Form S-8. The documents containing the information
specified in Part I will be delivered to the participants in the Plans as
required by Rule 428(b) under the Securities Act. Such documents are not being
filed with the Commission as part of this registration statement or as
prospectuses or prospectus supplements pursuant to Rule 424.





<PAGE>   3


                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

         The following documents have been filed by the Company with the
Commission and are incorporated herein by reference:

         (1)      Annual Report on Form 10-K for the fiscal year ended December
                  31, 1996;

         (2)      Quarterly Reports on Form 10-Q for the fiscal quarters ended
                  March 31, 1997, June 30, 1997 and September 30, 1997;

         (3)      Current Reports on Form 8-K dated February 7, 1997, March 5,
                  1997, August 29, 1997 and October 17, 1997; and

         (4)      Registration Statement on Form 8-A filed on February 28, 1994
                  and amended April 11, 1994 containing a description of the
                  Common Stock of the Company.

         All reports and other documents filed by the Company subsequent to the
date hereof pursuant to Sections 13(a), 13(c), 14, and 15(d) of the Securities
Exchange Act of 1934, prior to the filing of a post-effective amendment which
indicates that all securities offered under the plans have been sold or which
deregisters all securities then remaining unsold, shall be deemed to be
incorporated by reference in this registration statement and to be a part hereof
from the date of filing of such documents.

         Any statement contained in a document, all or a portion of which is
incorporated or deemed to be incorporated by reference herein, shall be deemed
modified or superseded for purposes of this Registration Statement to the
extent that a statement contained herein or in any other subsequently filed
document which also is or is deemed to be incorporated by reference herein
modifies or supersedes such statement. Any statement so modified shall not be
deemed to constitute a part of this Registration Statement except as so
modified, and any statement so superseded shall not be deemed to constitute
part of this Registration Statement. In particular, reference is made to the
Company's Current Report on Form 8-K dated October 17, 1997, which includes
consolidated financial statements and the related management's discussion and
analysis of financial condition and results of operations of the Company,
giving effect to the Company's pooling-of-interest transactions effected
between January 1, 1997 and August 31, 1997.

ITEM 4.  DESCRIPTION OF SECURITIES

         Not Applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

         Not Applicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Sections 55-8-50 through 55-8-58 of the North Carolina Business
Corporation Act permit a corporation to indemnify its directors, officers,
employees or agents under either or both a statutory or nonstatutory scheme of
indemnification. Under the statutory scheme, a corporation may, with certain
exceptions, indemnify a director, officer, employee or agent of the corporation
who was, is, or is threatened to be made, a party to any threatened, pending or
completed legal action, suit or proceeding, whether civil, criminal,
administrative, or investigative, because of the fact that such person was a
director, officer, agent or employee of the corporation, or is or was serving at
the request of such corporation as a director, officer, employee or agent of
another corporation or enterprise. This indemnity may include the obligation to
pay any judgment, settlement, penalty, fine (including an excise tax assessed
with respect to an employee benefit plan) and reasonable expenses incurred in
connection with a proceeding (including counsel fees), but no such
indemnification may be granted unless such director, officer, agent or employee
(i) conducted himself in good faith, (ii) reasonably believed (1) that any
action taken in his official capacity with the corporation was in the best
interest of the corporation or (2) that in all other cases his conduct at least
was not opposed to the corporation's best interest, and (iii) in the case of any
criminal proceeding, had no reasonable cause to believe his conduct was
unlawful. Whether a director has met the requisite standard of conduct for the
type of indemnification set forth above is determined by the board of directors,
a committee of directors, special legal counsel or the shareholders in
accordance with Section 55-8-55. A corporation may not indemnify a director
under the statutory scheme in connection with a proceeding by or in the right of
the corporation in which the director was 




                                       3
<PAGE>   4

adjudged liable to the corporation or in connection with a proceeding in which a
director was adjudged liable on the basis of having received an improper
personal benefit.

         In addition to, and separate and apart from the indemnification
described above under the statutory scheme, Section 55-8-57 of the North
Carolina Business Corporation Act permits a corporation to indemnify or agree to
indemnify any of its directors, officers, employees or agents against liability
and expenses (including attorney's fees) in any proceeding (including
proceedings brought by or on behalf of the corporation) arising out of their
status as such or their activities in any of the foregoing capacities, provided
a corporation may not indemnify or agree to indemnify a person against liability
or expenses he may incur on account of his activities that were, at the time
taken, known or believed by him to be clearly in conflict with the best interest
of the corporation. The Company's bylaws provide for indemnification to the
fullest extent permitted under the North Carolina Business Corporation Act,
provided, however, that the Company will indemnify any person seeking
indemnification in connection with a proceeding initiated by such person only if
such proceeding was authorized by the Board of Directors of the Company.
Accordingly, the Company may indemnify its directors, officers and employees in
accordance with either the statutory or the non-statutory standard.

         Sections 55-8-52 and 55-8-56 of the North Carolina Business Corporation
Act require a corporation, unless its articles of incorporation provide
otherwise, to indemnify a director or officer who has been wholly successful, on
the merits or otherwise, in the defense of any proceeding to which such director
or officer was a party. Unless prohibited by the articles of incorporation, a
director or officer also may make application and obtain court-ordered
indemnification if the court determines that such director or officer is fairly
and reasonably entitled to such indemnification as provided in Sections 55-8-54
and 55-8-56.

         Finally, Section 55-8-57 of the North Carolina Business Corporation Act
provides that a corporation may purchase and maintain insurance on behalf of an
individual who is or was a director, officer, employee or agent of the
corporation against certain liabilities incurred by such persons, whether or not
the corporation is otherwise authorized by the North Carolina Business
Corporation Act to indemnify such party. The Company's directors and officers
are currently covered under directors' and officers' insurance policies
maintained by the Company.

         As permitted by North Carolina law, Article XI of the Company's
Articles of Incorporation limits the personal liability of directors for
monetary damages for breaches of duty as a director provided that such
limitation will not apply to (i) acts or omissions that the director at the time
of the breach knew or believed were clearly in conflict with the best interests
of the Company, (ii) any liability for unlawful distributions under N.C. Gen.
Stat. Section 55-8-33, (iii) any transaction from which the director derived an
improper personal benefit, or (iv) acts or omissions occurring prior to the date
the provision became effective.

ITEM 7.  EXEMPTION FROM REGISTRATION CLAIMED

         Not Applicable.

ITEM 8.  EXHIBITS

         The following exhibits are filed or incorporated by reference as a part
of this registration statement:

Exhibit           Description
No.               -----------
- -------        
4.1(1)            Specimen Common Stock Certificate

4.2(2)            Amended and Restated Articles of Incorporation


                                       4
<PAGE>   5

4.3(3)            Amended and Restated Bylaws

5                 Opinion of Smith, Anderson, Blount, Dorsett, Mitchell &
                  Jernigan, L.L.P.

23.1              Consent of Smith, Anderson, Blount, Dorsett, Mitchell &
                  Jernigan, L.L.P. (contained in the opinion submitted as
                  Exhibit 5 hereto)

23.2              Consent of Ernst & Young LLP

23.3              Consent of KPMG

23.4              Consent of Coopers and Lybrand L.L.P.

24.1              Power of Attorney (included as part of the signature page)

99.1              Action International Marketing Services Limited Nonqualified
                  Stock Option Plan

99.2              Quintiles Transnational Corp. Nonqualified Stock Option Plan

99.3              Professional Pharmaceutical Marketing Services (Proprietary)
                  Limited Nonqualified Stock Option Plan

- ---------------------------

(1)      Filed as an exhibit to the Company's Registration Statement on Form S-1
         (Reg. No. 33-75766) initially filed February 28 1994, as amended, and
         incorporated by reference herein.

(2)      Filed as an exhibit to the Company's Registration Statement on Form S-3
         (Reg. No. 333-19009) initially filed December 30, 1996, as amended, and
         incorporated by reference herein.

(3)      Filed as an exhibit to the Company's Annual Report on Form 10-K for the
         fiscal year ended December 31, 1995, as filed on March 25, 1996 and
         amended on May 16, 1996, and incorporated by reference herein.

ITEM 9.  UNDERTAKINGS

         The undersigned registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
         a post-effective amendment to this registration statement:

                  (i) To include any prospectus required by section 10(a)(3) of
                  the Securities Act of 1933;

                  (ii) To reflect in the prospectus any facts or events arising
                  after the effective date of the registration statement (or the
                  most recent post-effective amendment thereof) which,
                  individually or in the aggregate, represent a fundamental
                  change in the information set forth in the registration
                  statement;

                  (iii) To include any material information with respect to the
                  plan of distribution not previously disclosed in the
                  registration statement or any material change to such
                  information in the registration statement.

                  Provided, however, that paragraphs (a)(1)(i) and (a)(1)(ii) do
                  not apply if the registration statement is on Form S-3, Form
                  S-8, and the information required to be included in a
                  post-effective amendment by those paragraphs is contained in
                  periodic reports filed by the registrant pursuant to section
                  13 or section 15(d) of the Securities Exchange Act of 1934
                  that are incorporated by reference in the registration
                  statement.


                                       5
<PAGE>   6

         (2) That, for the purpose of determining any liability under the
         Securities Act of 1933, each such post-effective amendment shall be
         deemed to be a new registration statement relating to the securities
         offered therein, and the offering of such securities at that time shall
         be deemed to be the initial bona fide offering thereof; and

         (3) To remove from registration by means of a post-effective amendment
         any of the securities being registered which remain unsold at the
         termination of the offering.

         The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to section 13(a) or section 15(d) of the
Securities Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to Section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         Insofar as indemnification for liabilities arising under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the registrant pursuant to the foregoing provisions, or otherwise, the
registrant has been advised that in the opinion of the Securities and Exchange
Commission such indemnification is against public policy as expressed in the Act
and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.





                                       6
<PAGE>   7




                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this registration
statement to be signed on its behalf by the undersigned, thereunto duly
authorized, in the City of Durham, State of North Carolina, on the 18th day of
November, 1997.


                                         QUINTILES TRANSNATIONAL CORP.



                                         By: /s/ Dennis B. Gillings
                                             ----------------------------------
                                             Dennis B. Gillings
                                             Chairman of the Board of Directors
                                             and Chief Executive Officer




                                       7
<PAGE>   8

                                POWER OF ATTORNEY

         KNOW ALL MEN BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Dennis B. Gillings and Rachel R. Selisker
and each of them, each with full power to act without the other, his true and
lawful attorneys-in-fact and agents, with full powers of substitution and
resubstitution, for him and in his name, place and stead, in any and all
capacities, to sign any or all amendments to this Registration Statement on Form
S-8 and to file the same, with all exhibits thereto, and other documents in
connection therewith, with the Securities and Exchange Commission, granting unto
said attorneys-in-fact and agents full power and authority to do and perform
each and every act and thing requisite and necessary to be done in and about the
premises, as fully for all intents and purposes as he or she might or could do
in person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, or their substitutes, may lawfully do or cause to be done by virtue
hereof.

         Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed by the following persons as of
November 18, 1997 in the capacities indicated.

      Signature                                      Title
      ---------                                      -----  

/s/ Dennis B. Gillings           Chairman of the Board of Directors and Chief 
- -------------------------        Executive Officer
Dennis B. Gillings

/s/ Santo J. Costa               President, Chief Operating Officer and Director
- -------------------------
Santo J. Costa

/s/ Rachel R. Selisker           Chief Financial Officer, Executive Vice 
- -------------------------        President Finance, and Director 
Rachel R. Selisker               (Principal accounting and financial officer)

/s/ Robert C. Bishop             Director
- -------------------------
Robert C. Bishop

/s/ Vaughn D. Bryson             Director
- -------------------------
Vaughn D. Bryson

/s/ Chester W. Douglass          Director
- -------------------------
Chester W. Douglass

/s/ Paul Knott                   Director
- -------------------------
Paul Knott

/s/ Lawrence S. Lewin            Director
- -------------------------
Lawrence S. Lewin

/s/ Arthur M. Pappas             Director
- -------------------------
Arthur M. Pappas

/s/ Ludo J. Reynders             Director
- -------------------------
Ludo J. Reynders

                                 Director
- -------------------------
Eric J. Topol

                                 Director
- -------------------------
Virginia V. Weldon

                                 Director
- -------------------------
David F. White



                                       8
<PAGE>   9




                          QUINTILES TRANSNATIONAL CORP.
                                  EXHIBIT INDEX


Exhibit           
No.               Description
- -------           -----------
4.1(1)            Specimen Common Stock Certificate

4.2(2)            Amended and Restated Articles of Incorporation

4.3(3)            Amended and Restated Bylaws

5                 Opinion of Smith, Anderson, Blount, Dorsett, Mitchell &
                  Jernigan, L.L.P.

23.1              Consent of Smith, Anderson, Blount, Dorsett, Mitchell &
                  Jernigan, L.L.P. (contained in the opinion submitted as
                  Exhibit 5 hereto)

23.2              Consent of Ernst & Young LLP

23.3              Consent of KPMG

23.4              Consent of Coopers and Lybrand L.L.P.

24.1              Power of Attorney (included as part of the signature page)

99.1              Action International Marketing Services Limited Nonqualified
                  Stock Option Plan

99.2              Quintiles Transnational Corp. Nonqualified Stock Option Plan

99.3              Professional Pharmaceutical Marketing Services (Proprietary)
                  Limited Nonqualified Stock Option Plan

- ---------------------------

(1)      Filed as an exhibit to the Company's Registration Statement on Form S-1
         (Reg. No. 33-75766) initially filed February 28 1994, as amended, and
         incorporated by reference herein.

(2)      Filed as an exhibit to the Company's Registration Statement on Form S-3
         (Reg. No. 333-19009) initially filed December 30, 1996, as amended, and
         incorporated by reference herein.

(3)      Filed as an exhibit to the Company's Annual Report on Form 10-K for the
         fiscal year ended December 31, 1995, as filed on March 25, 1996 and
         amended on May 16, 1996, and incorporated by reference herein.




<PAGE>   1


                                                                       EXHIBIT 5

          Smith, Anderson, Blount, Dorsett, Mitchell & Jernigan, L.L.P.
                                     Lawyers
                         2500 First Union Capitol Center
                          Raleigh, North Carolina 27601
                               Phone: 919-821-1220
                                Fax: 919-821-6800

                               November 18, 1997


Quintiles Transnational Corp.
4709 Creekstone Drive
Riverbirch Building, Suite 300
Durham, North Carolina  27703-8411

Ladies and Gentlemen:

         As counsel for Quintiles Transnational Corp. (the "Company"), we
furnish the following opinion in connection with the proposed issuance by the
Company of up to 1,347,097 shares of its common stock, $0.01 par value (the
"Common Stock"), pursuant to the Action International Marketing Services Limited
Nonqualified Stock Option Plan, the Quintiles Transnational Nonqualified
Stock Option Plan and the Professional Pharmaceutical Marketing Services
(Proprietary) Limited Nonqualified Stock Option Plan (collectively, the 
"Plans"). These securities are the subject of a Registration Statement to be
filed by the Company with the Securities and Exchange Commission on Form S-8
(the "Registration Statement") under the Securities Act of 1933, as amended
(the "1933 Act"), to which this opinion is to be attached as an exhibit.

         We have examined the Restated Articles of Incorporation and Bylaws of
the Company, the minutes of meetings of its Board of Directors, and such other
corporate records of the Company and other documents and have made such
examinations of law as we have deemed relevant for purposes of this opinion. We
also have received a certificate of an officer of the Company, dated of even
date herewith, relating to the issuance of the Common Stock pursuant to the
Plans. Based on such examination and such certificate it is our opinion that the
1,347,097 shares of Common Stock of the Company, which are being registered
pursuant to the Registration Statement, may be legally issued in accordance with
the Company's Restated Articles of Incorporation and Bylaws, and when so issued
and duly delivered against payment therefor pursuant to the Plans as described
in the Registration Statement, such shares will be legally issued, fully paid,
and nonassessable.

         We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement that you are about to file with the Securities and
Exchange Commission. Such consent shall not be deemed to be an admission that
this firm is within the category of persons whose consent is required under
Section 7 of the 1933 Act or the regulations promulgated pursuant to the 1933
Act.

                                Sincerely yours,

                                SMITH, ANDERSON, BLOUNT, DORSETT,
                                       MITCHELL & JERNIGAN, L.L.P.



                                /s/ SMITH, ANDERSON, BLOUNT, DORSETT,
                                       MITCHELL & JERNIGAN, L.L.P.






<PAGE>   1




                                                                    EXHIBIT 23.2

                        CONSENT OF INDEPENDENT AUDITORS



We consent to the incorporation by reference in the Registration Statement (Form
S-8) of our report dated October 14, 1997, with respect to the consolidated
financial statements of Quintiles Transnational Corp. included in its Current
Report on Form 8-K dated October 17, 1997, filed with the Securities and
Exchange Commission.


                                              /s/ Ernst & Young LLP

                                                  Ernst & Young LLP
 


Raleigh, North Carolina
November 14, 1997




<PAGE>   1


                                                                    EXHIBIT 23.3

                        CONSENT OF INDEPENDENT AUDITORS



We consent to the incorporation by reference in the Registration Statement on
Form S-8 (dated November 17, 1997) of Quintiles Transnational Corp. of our
report dated 24 July 1996, with respect to the combined balance sheets as of
March 31, 1996 and 1995 and the combined statements of income and cash flows for
each of the years in the three year period ended March 31, 1996 of the Innovex
Companies included in the Current Report on Form 8-K of Quintiles Transnational
Corp. dated October 17, 1997.




/s/ KPMG

Reading, England
November 17, 1997




<PAGE>   1


                                                                    EXHIBIT 23.4

                       CONSENT OF INDEPENDENT ACCOUNTANTS



We consent to the incorporation by reference in the Registration Statement of
Quintiles Transnational Corp. ("Quintiles") on Form S-8 of our report dated May
15, 1996 on our audits of the consolidated financial statements of BRI
International, Inc. as of November 30, 1995 and 1994, and for the years then
ended, which report is included as an exhibit to Quintiles' Current Report on
Form 8-K dated October 17, 1997.




                                                 /s/ COOPERS & LYBRAND L.L.P.

                                                 COOPERS & LYBRAND L.L.P.




Rockville, Maryland
November 14, 1997




<PAGE>   1





                                                                    EXHIBIT 99.1

                 ACTION INTERNATIONAL MARKETING SERVICES LIMITED
                         NONQUALIFIED STOCK OPTION PLAN

1.       Purpose

The purpose of the Action International Marketing Services Limited Nonqualified
Stock Option Plan (the "Plan") is to further the success of Quintiles
Transnational Corp. (the "Company") by making shares of the Company's Common
Stock ("Common Stock") available for purchase by eligible employees, officers,
directors and consultants of Action International Marketing Services Limited
("Subsidiary") or any affiliated company or partnership in which the Subsidiary
has an ownership interest, and other persons receiving services from or
providing services to the Subsidiary in order to provide an additional incentive
to such persons to continue their relationship with the Company and in order to
give such persons a greater interest in the Company's success. This purpose will
be carried out through the granting of options which do not meet the statutory
requirements of Sections 422 or 423 of the Internal Revenue Code of 1996, as
amended.

2.       Stock Subject to Plan

Subject to the provisions of Section 9 of the Plan, the Company's Board of
Directors (the "Board') shall reserve initially an aggregate of 89,120
authorized and unissued shares of Common Stock for issuance upon the exercise of
the options. The Board may from time to time reserve additional shares of
authorized and unissued Common Stock for issuance upon exercise of options.

3.       Administration

The Board shall designate a committee of at least two "Nonemployee Directors" as
defined in Rule 16b-3(b)(3) promulgated under Section 16 of the Securities
Exchange Act of 1934 (the "Committee") to administer the Plan. The Committee
shall report all of its actions to the Board. The board may from time to time
remove members from 


                                       1
<PAGE>   2

the Committee and appoint their successors. The Board shall fill all vacancies
on the Committee however caused. Except as otherwise expressly provided in the
Plan, the Committee shall have absolute discretionary authority (a) to determine
the individuals to receive options, the times when options shall be granted, the
number of shares to be subject to each option, the option price, the option
period, and the time or times when each option shall be exercisable; (b) to
interpret the Plan; (c) to prescribe, amend and rescind rules and regulations in
relation to the Plan; (d) to determine the terms and provisions (and amendments
of the terms and provisions) of the option agreements to be entered into between
the Company and each Participant granted an option under the Plan (which option
agreements need not be identical), including such terms and provisions as shall
be required in the Committee's judgment to conform to any change in any
applicable law or regulation; and (e) to make all other determinations the
Committee shall deem necessary or advisable for the plan's administration.

No member of the Committee or the Board shall be liable to any person for any
action or determination which he or she makes in good faith.

4.       Eligibility

Subject to the provisions of Section 3, any employee, officer, director and
consultant of the Subsidiary or any affiliated company or partnership in which
the Subsidiary has an ownership interest and other persons receiving services
from or providing services to the Subsidiary designated by the Committee shall
be eligible to receive options under the Plan (the "Participants"). In
designating Participants and in recommending the number of shares of Common
Stock to be covered by each option granted to a Participant, the Committee may
take into account the nature of the services rendered by or for each
Participant, his or her present and potential contributions to the Company's
success and such other factors as the Committee in its discretion shall deem
relevant. The Company may grant additional options to Participants who have
already been granted options under the Plan.




                                       2
<PAGE>   3



5.       Option Price

The purchase price of the shares of Common Stock covered by each option shall be
the closing price of a share of the Company's Common Stock on the NASDAQ
National Market on Tuesday 10th June 1997.

6.       Exercise of Option

The period during which an option may be exercised shall be as set out in the
option agreement relating to such option but shall not extend more than ten (10)
years from the date on which the option is granted. The term of each option,
however, shall not extend for more than the period prescribed in Sections 8, 9
and 10 of the Plan. Except as provided in the option agreement relating to such
option, an option may be exercised in whole or in part at any time during its
term. The Committee may impose vesting or other restrictions on the
exercisability or conditions of options. The purchase price of the shares of
Common Stock subject to the option shall be paid in full in cash upon the
exercise of the option. The holder of an option under the Plan shall not have
any of the rights of a shareholder with respect to the Common Stock subject to
the option until such shares shall be issued to him or her upon the exercise of
the option and payment of the purchase price.

7.       Transferability Option

Except as determined by the Committee and set forth in the Option agreement
relating to such option, no option granted under the Plan shall be transferable
other than by will or by the laws of descent and distribution (including by
pledge or hypothecation) and shall be exercisable only by the Participant or his
or her duly appointed legal representative.




                                       3
<PAGE>   4


8.       Termination and relationship with the Company

The times and conditions upon which an option will terminate where a Participant
to whom an option has been granted under the Plan terminates, or the Company
terminates, his or her employment, consultant, or service relationship with the
Subsidiary or an affiliated company or partnership in which the Subsidiary has
an ownership interest shall be determined by the Committee when the option is
granted; provided, however, that in no event shall an option be exercisable more
than ten (10) years from the date it was granted. Nothing in the plan or any
option granted pursuant to the Plan shall (a) confer on any individual any right
to continue in the employ of the Company or to continue any consultant or
service relationship with the Company or (b) interfere in any way with the
Company's right to terminate such individual's employment, consultant or service
relationship at any time.

9.       Adjustment Upon Changes in Capitalization

In the event of a change in the Company's Common Stock by reason of any stock
dividend, split-up, recapitalization, combination or exchange of shares, merger,
consolidation, acquisition of property or stock, separation, reorganization or
liquidation or similar action, the Committee shall make an appropriate
adjustment of the number and class of shares of Common Stock subject to, and the
purchase price for, each then outstanding option, consistent with and as
provided in the corresponding option agreement under the Plan. In the event of
any such change in the outstanding Common Stock, the Committee shall adjust
appropriately the aggregate number and class of shares of Common Stock reserved
and available under the Plan appropriately, and the Committee's determination on
adjustment shall be conclusive.

10.      Termination of Options on Merger or Sale of Assets

10.1. A liquidation of the Company, a merger or consolidation in which the
Company is not the surviving or resulting corporation, or a sale of all or
substantially all of the Company's assets shall cause every option outstanding
under the Plan to 


                                       4
<PAGE>   5

terminate on the effective date of such action. Notwithstanding the preceding
sentence, upon a liquidation of the Company, a merger or consolidation in which
the Company is not the surviving or resulting corporation, or a sale of all or
substantially all of the Company's assets, each option holder shall have the
right within his or her sole discretion, to exercise before the effective date
of such action (the "Effective Date") any or all of the options he or she then
holds, but only to the extent that such options are otherwise exercisable under
the terms of the Plan. Any option not so exercised shall terminate on the
Effective Date.

10.2. Notwithstanding the provisions of Section 10.1. the Committee, in its
discretion, may declare prior to the Effective Date any or all then outstanding
options under this Plan not previously exercisable and vested as immediately
exercisable and fully vested in whole or in part ALWAYS PROVIDED THAT the
Committee shall exercise any such discretion to ensure that the option holders
under this Plan shall be treated on an equivalent basis to option holders under
the Company's Equity Compensation Plan.

11.      Registration

The Company shall use its best efforts to file by 1st August 1997 an S.8.
Registration Statement in respect of the options capable of being issued
pursuant to this Plan.

12.      Amendment, Suspension or Termination of the Plan

The Board may at any time suspend or terminate the Plan or may amend it from
time to time in such respect as the Board may deem advisable in order that the
options granted under the Plan may conform to any changes in the law or in any
other respect which the Board may deem to be in the best interest of the
Company. Modifications or amendments to the Plan are not required to be approved
by the Company's shareholders except to the extent required by applicable North
Carolina law or by the Company's Bylaws. No termination, modification, or
amendment to the plan without the consent of the Participant to whom any option
shall have been previously granted shall adversely affect such Participant's
rights under such option. Unless terminated



                                       5
<PAGE>   6




earlier in accordance with this Section, the Plan shall terminate when all
shares of Common Stock reserved for issuance under the Plan have been issued.

13.      Effectiveness of the Plan

The Plan shall become effective on such date as the Board shall determine. The
exercise of each option granted pursuant to the Plan shall be subject to the
condition that if at any time the Company shall determine in its discretion that
(a) the satisfaction of withholding tax or other withholding liabilities, (b)
the listing on any securities exchange or the registration or qualification
under any state or federal law of any shares of Common Stock otherwise
deliverable upon its exercise, or (c) the consent or approval of any regulatory
body or the shareholders is necessary or desirable as a condition of, or in
connection with, such exercise or the delivery or purchase of shares of Common
Stock pursuant to such exercise, then, in any such event, such exercise shall
not be effective unless such withholding, listing, registration, qualification,
consent or approval shall have been effected or obtained free of any conditions
unacceptable to the Company.

14.      Time of Granting Options

Nothing contained in the Plan or in any resolution adopted or to be adopted by
the Board or the Committee will constitute the granting of an option pursuant to
the Plan. The granting of an option pursuant to the Plan will occur only when a
written option agreement is duly executed and delivered by and on behalf of the
Company and the Participant to whom such option is to be granted.

15.      Applicable Law

Except as otherwise provided herein, the Plan shall be construed and enforced
according to the laws of the State of North Carolina USA.




                                       6
<PAGE>   7




         IN WITNESS WHEREOF, the Company has caused the Plan to be executed by
the action of its duly authorized officer this 11th day of June 1997.

                                            QUINTILES TRANSNATIONAL CORP.


                                            By: /s/ Paul Knott
                                                -------------------
                                                Director

ATTEST:


/s/ Ludo Reynders
- -----------------
Director



                                       7

<PAGE>   1





                                                                    EXHIBIT 99.2

                          QUINTILES TRANSNATIONAL CORP.
                         NONQUALIFIED STOCK OPTION PLAN


1.       PURPOSE

         The purpose of the Quintiles Transnational Nonqualified Stock Option
Plan (the "Plan") is to further the success of Quintiles Transnational Corp.
(the "Company") by making shares of the Company's Common Stock ("Common Stock")
available for purchase by eligible employees, officers, directors and
consultants of the Company, or any affiliated company or partnership in which
the Company has an ownership interest, and other persons receiving services from
or providing services to the Company, in order to provide an additional
incentive to such persons to continue their relationship with the Company and in
order to give such persons a greater interest in the Company's success. This
purpose will be carried out through the granting of options which do not meet
the statutory requirements of Sections 422 or 423 of the Internal Revenue Code
of 1986, as amended.

2.       STOCK SUBJECT TO PLAN

         Subject to the provisions of Section 9 of the Plan, the Company's Board
of Directors (the "Board") shall reserve initially for issuance upon the
exercise of the options an aggregate of 1,250,000 authorized and unissued shares
of Common Stock, plus five percent (5%) of any increase, other than any increase
due to the issuance of shares under the Plan or any similar plan of the Company,
in the authorized and issued shares above the number of authorized and issued
shares of Common Stock, or other securities directly or indirectly exercisable
for or convertible into Common Stock, as of the Effective Date of the Plan. The
Board may from time to time reserve additional shares of authorized and unissued
Common Stock for issuance upon exercise of options. If any option granted under
the Plan shall expire or terminate for any reason without having been exercised
in full, the unpurchased shares of Common Stock subject to the expired or
terminated option shall again be available for options under the Plan.

3.       ADMINISTRATION

         The Board shall designate a committee of at least two "Nonemployee
Directors" as defined in Rule 16b-3(b)(3) promulgated under Section 16 of the
Securities Exchange Act of 1934 (the "Committee") to administer the Plan. The
Committee shall report all of its actions to the Board. The Board may from time
to time remove members from the Committee and appoint their successors. The
Board shall fill all vacancies on the Committee however caused. Except as
otherwise expressly provided in the Plan, the Committee shall have absolute
discretionary authority (a) to determine the individuals to receive options, the
times when options shall be granted, the number of shares to be subject to each
option, the option price, the option period, and the time or times when each
option shall be exercisable; (b) to interpret the Plan; (c) to prescribe, amend,
and rescind rules and regulations relating to the Plan; (d) to determine the
terms and provisions (and amendments of the terms and provisions) of the option
agreements to be entered into between the Company and each Participant granted
an option under the Plan (which option agreements need not be identical),
including such terms and provisions as shall be required in the Committee's
judgment to conform to any change in any applicable law or regulation; and (e)
to make all other determinations the Committee shall deem necessary or advisable
for the Plan's administration.

         No member of the Committee or the Board shall be liable to any person
for any action or determination which he or she makes in good faith.

<PAGE>   2

4.       ELIGIBILITY

         Subject to the provisions of Section 3, any employee, officer,
director, and consultant of the Company or any affiliated company or partnership
in which the Company has an ownership interest and other persons receiving
services from or providing services to the Company designated by the Committee
shall be eligible to receive options under the Plan (the "Participants"). In
designating Participants and in recommending the number of shares of Common
Stock to be covered by each option granted to a Participant, the Committee may
take into account the nature of the services rendered by or for each
Participant, his or her present and potential contributions to the Company's
success, and such other factors as the Committee in its discretion shall deem
relevant. The Company may grant additional options to Participants who have
already been granted options under the Plan.

5.       OPTION PRICE

         The Committee shall determine the purchase price of the shares of
Common Stock covered by each option, which purchase price may be above or below
the fair market value of the Common Stock at the time of the grant, as
determined by the Committee.

6.       EXERCISE OF OPTION

         The period during which an option may be exercised shall be determined
by the Committee when the option is granted and shall not extend more than ten
(10) years from the date on which the option is granted. The term of each
option, however, shall not extend for more than the period prescribed in
Sections 8, 9 and 10 of the Plan. Except as provided in the option agreement
relating to such option, an option may be exercised in whole or in part at any
time during its term. The Committee may impose vesting or other restrictions on
the exercisability or conditions of options. Except as provided in the option
agreement relating to such option, the purchase price of the shares of Common
Stock subject to the option shall be paid in full in cash upon the exercise of
the option. If the option agreement so provides, the purchase price may be paid
in whole or in part by surrendering shares of Common Stock or by surrendering
the option to the Company. If shares or options are used to pay all or part of
the purchase price, the cash and any shares or options surrendered must have a
fair market value (determined as of the day preceding the date of exercise) that
is not less than the purchase price for the number of shares for which the
option is being exercised. The holder of an option under the Plan shall not have
any of the rights of a shareholder with respect to the Common Stock subject to
the option until such shares shall be issued to him or her upon the exercise of
the option and payment of the purchase price.

7.       TRANSFERABILITY OF OPTION

         Except as determined by the Committee and set forth in the option
agreement relating to such option, no option granted under the Plan shall be
transferable other than by will or by the laws of descent and distribution
(including by pledge or hypothecation) and shall be exercisable only by the
Participant or his or her duly appointed legal representative.


                                       2
<PAGE>   3

 8.      TERMINATION OF RELATIONSHIP WITH THE COMPANY

         The times and conditions upon which an option will terminate where a
Participant to whom an option has been granted under the Plan terminates, or the
Company terminates, his or her employment, consultant, or service relationship
with the Subsidiary or an affiliated company or partnership in which the
Subsidiary has an ownership interest shall be determined by the Committee when
the option is granted; provided, however, that in no event shall an option be
exercisable more than ten (10) years from the date it was granted. Nothing in
the Plan or any option granted pursuant to the Plan shall (a) confer on any
individual any right to continue in the employ of the Company or to continue any
consultant or service relationship with the Company or (b) interfere in any way
with the Company's right to terminate such individual's employment, consultant
or service relationship at any time.

9.       ADJUSTMENT UPON CHANGES IN CAPITALIZATION

         In the event of a change in the Company's Common Stock by reason of any
stock dividend, split-up, recapitalization, combination or exchange of shares,
merger, consolidation, acquisition of property or stock, separation,
reorganization or liquidation or similar action, the Committee shall make an
appropriate adjustment of the number and class of shares of Common Stock subject
to and the purchase price for each then outstanding option, consistent with and
as provided in the corresponding option agreement under the Plan. In the event
of any such change in the outstanding Common Stock, the Committee shall adjust
appropriately the aggregate number and class of shares of Common Stock reserved
and available under the Plan appropriately, and the Committee's determination on
adjustment shall be conclusive.

10.      TERMINATION OF OPTIONS ON MERGER OR SALE OF ASSETS

         A liquidation of the Company, a merger or consolidation in which the
Company is not the surviving or resulting corporation, or a sale of all or
substantially all of the Company's assets shall cause every option outstanding
under the Plan to terminate on the effective date of such action.
Notwithstanding the preceding sentence, upon a liquidation of the Company, a
merger or consolidation in which the Company is not the surviving or resulting
corporation, or a sale of all or substantially all of the Company's assets, each
option holder shall have the right, within his or her sole discretion, to
exercise before the effective date of such action any or all of the options he
or she then holds, but only to the extent that such options are otherwise
exercisable under the terms of the Plan. Any options not so exercised shall
terminate on the effective date of such action.

11.      AMENDMENT, SUSPENSION, OR TERMINATION OF THE PLAN

         The Board may at any time suspend or terminate the Plan or may amend it
from time to time in such respects as the Board may deem advisable in order that
the options granted under the Plan may conform to any changes in the law or in
any other respect which the Board may deem to be in the best interest of the
Company. Modifications or amendments to the Plan are not required to be approved
by the Company's shareholders, except to the extent required by law or by the
Company's bylaws. No termination, modification, or amendment of the Plan without
the consent of the Participant to whom any option shall have been previously
granted shall adversely affect such Participant's rights under such option.
Unless terminated earlier in accordance with this Section, the Plan shall
terminate when all shares of Common Stock reserved for issuance under the Plan
have been issued.


                                       3
<PAGE>   4


12.      EFFECTIVENESS OF THE PLAN

         The Plan shall become effective on such date as the Board shall
determine (the "Effective Date"). The exercise of each option granted pursuant
to the Plan shall be subject to the condition that if at any time the Company
shall determine in its discretion that (a) the satisfaction of withholding tax
or other withholding liabilities, (b) the listing on any securities exchange or
the registration or qualification under any state or federal law of any shares
of Common Stock otherwise deliverable upon its exercise, or (c) the consent or
approval of any regulatory body or the shareholders is necessary or desirable as
a condition of, or in connection with, such exercise or the delivery or purchase
of shares of Common Stock pursuant to such exercise, then, in any such event,
such exercise shall not be effective unless such withholding, listing,
registration, qualification, consent or approval shall have been effected or
obtained free of any conditions unacceptable to the Company.

13.      TIME OF GRANTING OPTIONS

         Nothing contained in the Plan or in any resolution adopted or to be
adopted by the Board or the Committee will constitute the granting of an option
pursuant to the Plan. The granting of an option pursuant to the Plan will occur
only when a written option agreement is duly executed and delivered by and on
behalf of the Company and the Participant to whom such option is to be granted.

14.      APPLICABLE LAW

         Except as otherwise provided herein, the Plan shall be construed and
enforced according to the laws of the State of North Carolina.

         IN WITNESS WHEREOF, the Company has caused the Plan to be executed by
the action of its duly authorized officers this 24th day of July, 1997.

                                         QUINTILES TRANSNATIONAL CORP.


                                         By:    /s/ Gregory D. Porter
                                                ----------------------------
                                         Name:  Gregory D. Porter
                                                ----------------------------
                                         Title: Executive Vice President
                                                General Counsel
                                                Corporate Secretary
                                                ----------------------------


ATTEST:

/s/ Martha Henderson
- ------------------------------
Assistant Secretary

[CORPORATE SEAL]






                                       4

<PAGE>   1
                                                                    EXHIBIT 99.3



                 PROFESSIONAL PHARMACEUTICAL MARKETING SERVICES
                             (PROPRIETARY) LIMITED
                         NONQUALIFIED STOCK OPTION PLAN


1.       PURPOSE

The purpose of the Professional Pharmaceutical Marketing Services (Proprietary)
Limited Nonqualified Stock Option Plan (the "Plan") is to further the success of
Quintiles Transnational Corp. (the "Company") by making shares of the Company's
Common Stock ("Common Stock") available for purchase by eligible employees,
officers, directors and consultants of Professional Pharmaceutical Marketing
Services (Proprietary) Limited ("Subsidiary") or any affiliated company or
partnership in which the Subsidiary has an ownership interest, and other persons
receiving services from or providing services to the Subsidiary in order to
provide an additional incentive to such persons to continue their relationship
with the Company and in order to give such persons a greater interest in the
Company's success. This purpose will be carried out through the granting of
options which do not meet the statutory requirements of Sections 422 or 423 of
the Internal Revenue Code of 1986, as amended.

2.       STOCK SUBJECT TO PLAN

Subject to the provisions of Section 9 of the Plan, the Company's Board of
Directors (the "Board") shall reserve initially an aggregate of 7,977 authorised
and unissued shares of Common Stock for issuance upon the exercise of the
options. The Board may from time to time reserve additional shares of authorised
and unissued Common Stock for issuance upon exercise of options.

3.       ADMINISTRATION

The Board shall designate a committee of at least two "Nonemployee Directors" as
defined in Rule 16b-3(b)(3) promulgated under Section 16 of the Securities
Exchange Act of 1934 (the "Committee") to administer the Plan. The Committee
shall report all of its actions to the Board. The Board may from time to time
remove members from the Committee and appoint their successors. The Board shall
fill all vacancies on the Committee however caused. Except as otherwise
expressly provided in the Plan, the Committee shall have absolute discretionary
authority (a) to determine the individuals to receive options, the times when
options shall be granted, the number of shares to be 


                                       1
<PAGE>   2

subject to each option, the option price, the option period, and the time or
times when each option shall be exercisable; (b) to interpret the Plan; (c) to
prescribe, amend and rescind rules and regulations in relation to the Plan; (d)
to determine the terms and provisions (and amendments of the terms and
provisions) of the option agreements to be entered into between the Company and
each Participant granted an option under the Plan (which option agreements need
not be identical), including such terms and provisions as shall be required in
the Committee's judgment to conform to any change in any applicable law or
regulation; and (e) to make all other determinations the Committee shall deem
necessary or advisable for the plan's administration.

No member of the Committee or the Board shall be liable to any person for any
action or determination which he or she makes in good faith.

4.       ELIGIBILITY

Subject to the provisions of Section 3, any employee, officer, director and
consultant of the Subsidiary or any affiliated company or partnership in which
the Subsidiary has an ownership interest and other persons receiving services
from or providing services to the Subsidiary designated by the Committee shall
be eligible to receive options under the Plan (the "Participants"). In
designating Participants and in recommending the number of shares of Common
Stock to be covered by each option granted to a Participant, the Committee may
take into account the nature of the services rendered by or for each
Participant, his or her present and potential contributions to the Company's
success and such other factors as the Committee in its discretion shall deem
relevant. The Company may grant additional options to Participants who have
already been granted options under the Plan.

5.       OPTION PRICE

The purchase price of the shares of Common Stock covered by each option shall be
the closing price of a share of the Company's Common Stock on the NASDAQ
National Market on the trading day immediately prior to the date of execution of
the Plan.

6.       EXERCISE OF OPTION


                                       2
<PAGE>   3

The period during which an option may be exercised shall be as set out in the
option agreement relating to such option but shall not extend more than ten (10)
years from the date on which the option is granted. The term of each option,
however, shall not extend for more than the period prescribed in Sections 8, 9
and 10 of the Plan. Except as provided in the option agreement relating to such
option, an option may be exercised in whole or in part at any time during its
term. The Committee may impose vesting or other restrictions on the
exercisability or conditions of options. The purchase price of the shares of
Common Stock subject to the option shall be paid in full in cash upon the
exercise of the option. The holder of an option under the Plan shall not have
any of the rights of a shareholder with respect to the Common Stock subject to
the option until such shares shall be issued to him or her upon the exercise of
the option and payment of the purchase price.

7.       TRANSFERABILITY OF OPTION

Except as determined by the Committee and set forth in the Option agreement
relating to such option, no option granted under the Plan shall be transferable
other than by will or by the laws of descent and distribution (including by
pledge or hypothecation) and shall be exercisable only by the Participant or his
or her duly appointed legal representative.

8.       TERMINATION AND RELATIONSHIP WITH THE COMPANY

The times and conditions upon which an option will terminate where a Participant
to whom an option has been granted under the Plan terminates, or the Company
terminates, his or her employment, consultant, or service relationship with the
Subsidiary or an affiliated company or partnership in which the Subsidiary has
an ownership interest shall be determined by the Committee when the option is
granted; provided, however, that in no event shall an option be exercisable more
than ten (10) years from the date it was granted. Nothing in the plan or any
option granted pursuant to the Plan shall (a) confer on any individual any right
to continue in the employ of the Company or to continue any consultant or
service relationship with the Company or (b) interfere in any way with the
Company's right to terminate such individual's employment, consultant or service
relationship at any time.



                                       3
<PAGE>   4

9.       ADJUSTMENT UPON CHANGES IN CAPITALIZATION

In the event of a change in the Company's Common Stock by reason of any stock
dividend, split-up, recapitalization, combination or exchange of shares, merger,
consolidation, acquisition of property or stock, separation, reorganization or
liquidation or similar action, the Committee shall make an appropriate
adjustment of the number and class of shares of Common Stock subject to, and the
purchase price for, each then outstanding option, consistent with and as
provided in the corresponding option agreement under the Plan. In the event of
any such change in the outstanding Common Stock, the Committee shall adjust
appropriately the aggregate number and class of shares of Common Stock reserved
and available under the Plan appropriately, and the Committee's determination on
adjustment shall be conclusive.

10.      TERMINATION OF OPTIONS ON MERGER OR SALE OF ASSETS

10.1.    A liquidation of the Company, a merger or consolidation in which the
Company is not the surviving or resulting corporation, or a sale of all or
substantially all of the Company's assets shall cause every option outstanding
under the Plan to terminate on the effective date of such action.
Notwithstanding the preceding sentence, upon a liquidation of the Company, a
merger or consolidation in which the Company is not the surviving or resulting
corporation, or a sale of all or substantially all of the Company's assets, each
option holder shall have the right, within his or her sole discretion, to
exercise before the effective date of such action (the "Effective Date") any or
all of the options he or she then holds, but only to the extent that such
options are otherwise exercisable under the terms of the Plan. Any option not so
exercised shall terminate on the Effective Date.

10.2.    Notwithstanding the provisions of Section 10.1. the Committee, in its
discretion, may declare prior to the Effective Date any or all then outstanding
options under this Plan not previously exercisable and vested as immediately
exercisable and fully vested in whole or in part.


                                       4
<PAGE>   5

11.      REGISTRATION

The Company shall use its best efforts to file by 31st October 1997 an S.8.
Registration Statement in respect of the options capable of being issued
pursuant to this Plan.

12.      AMENDMENT, SUSPENSION OR TERMINATION OF THE PLAN

The Board may at any time suspend or terminate the Plan or may amend it from
time to time in such respect as the Board may deem advisable in order that the
options granted under the Plan may conform to any changes in the law or in any
other respect which the Board may deem to be in the best interest of the
Company. Modifications or amendments to the Plan are not required to be approved
by the Company's shareholders except to the extent required by applicable North
Carolina law or by the Company's Bylaws. No termination, modification, or
amendment to the plan without the consent of the Participant to whom any option
shall have been previously granted shall adversely affect such Participant's
rights under such option. Unless terminated earlier in accordance with this
Section, the Plan shall terminate when all shares of Common Stock reserved for
issuance under the Plan have been issued.

13.      EFFECTIVENESS OF THE PLAN

The Plan shall become effective on such date as the Board shall determine. The
exercise of each option granted pursuant to the Plan shall be subject to the
condition that if at any time the Company shall determine in its discretion that
(a) the satisfaction of withholding tax or other withholding liabilities, (b)
the listing on any securities exchange or the registration or qualification
under any state or federal law of any shares of Common Stock otherwise
deliverable upon its exercise, or (c) the consent or approval of any regulatory
body or the shareholders is necessary or desirable as a condition of, or in
connection with, such exercise or the delivery or purchase of shares of Common
Stock pursuant to such exercise, then, in any such event, such exercise shall
not be effective unless such withholding, listing, registration, qualification,
consent or approval shall have been effected or obtained free of any conditions
unacceptable to the Company.

14.      TIME OF GRANTING OPTIONS



                                       5
<PAGE>   6

Nothing contained in the Plan or in any resolution adopted or to be adopted by
the Board or the Committee will constitute the granting of an option pursuant to
the Plan. The granting of an option pursuant to the Plan will occur only when a
written option agreement is duly executed and delivered by and on behalf of the
Company and the Participant to whom such option is to be granted.

15.      APPLICABLE LAW

Except as otherwise provided herein, the Plan shall be construed and enforced
according to the laws of the State of North Carolina USA.

IN WITNESS WHEREOF, the Company has caused the Plan to be executed by the action
of its duly authorised officer this 29th day of August 1997.


                                       6
<PAGE>   7





                                    QUINTILES TRANSNATIONAL CORP.




                                    By: /s/ Paul Knott
                                        ----------------------------
                                        Director


                                       7


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