QUINTILES TRANSNATIONAL CORP
S-3/A, 1997-02-18
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
Previous: XECHEM INTERNATIONAL INC, SC 13G, 1997-02-18
Next: FPA MEDICAL MANAGEMENT INC, 424B3, 1997-02-18



<PAGE>   1
 
   
   AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON FEBRUARY 18, 1997
    
 
   
                                                      REGISTRATION NO. 333-19009
    
================================================================================
 
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549
                             ---------------------
 
   
                                AMENDMENT NO. 1
    
   
                                       TO
    
 
                                    FORM S-3
            REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933
                             ---------------------
 
                         QUINTILES TRANSNATIONAL CORP.
             (Exact name of registrant as specified in its charter)
 
<TABLE>
<S>                                            <C>
                NORTH CAROLINA                                   56-1714315
(State or other jurisdiction of incorporation       (I.R.S. Employer Identification No.)
               or organization)
</TABLE>
 
                             4709 CREEKSTONE DRIVE
                         RIVERBIRCH BUILDING, SUITE 300
                       DURHAM, NORTH CAROLINA 27703-8411
                                 (919) 941-2000
  (Address, including zip code, and telephone number, including area code, of
                   registrant's principal executive offices)
 
                           DENNIS B. GILLINGS, PH.D.
                      CHAIRMAN AND CHIEF EXECUTIVE OFFICER
                         QUINTILES TRANSNATIONAL CORP.
                             4709 CREEKSTONE DRIVE
                         RIVERBIRCH BUILDING, SUITE 300
                       DURHAM, NORTH CAROLINA 27703-8411
                                 (919) 941-2000
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)
                             ---------------------
 
                                   COPIES TO:
 
                             GERALD F. ROACH, ESQ.
                              AMY J. MEYERS, ESQ.
                            SMITH, ANDERSON, BLOUNT,
                      DORSETT, MITCHELL & JERNIGAN, L.L.P.
                        2500 FIRST UNION CAPITOL CENTER
                         RALEIGH, NORTH CAROLINA 27601
                                 (919) 821-1220
                             ---------------------
 
    APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC: From time
to time after this registration statement becomes effective.
    If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, please check the following
box.  [ ]
    If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box.  [X]
    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering.  [ ]
    If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering.  [ ]
    If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box.  [ ]
                             ---------------------
 
                        CALCULATION OF REGISTRATION FEE
 
   
<TABLE>
<CAPTION>
=================================================================================================================
                                                           PROPOSED            PROPOSED
                                         AMOUNT             MAXIMUM             MAXIMUM            AMOUNT OF
       TITLE OF EACH CLASS               TO BE          OFFERING PRICE         AGGREGATE         REGISTRATION
 OF SECURITIES TO BE REGISTERED        REGISTERED       PER SECURITY(1)    OFFERING PRICE(1)          FEE
- -----------------------------------------------------------------------------------------------------------------
<S>                                <C>                <C>                 <C>                 <C>
4.25% Convertible Subordinated
  Notes Due May 31, 2000.........     $126,075,000           100%            $126,075,000        $38,204.55(2)
- -----------------------------------------------------------------------------------------------------------------
Common Stock, $.01 par value.....     1,523,565(3)            N/A                 N/A               N/A(4)
=================================================================================================================
</TABLE>
    
 
(1) Estimated solely for the purpose of calculating the registration fee in
    accordance with Rule 457(i). Exclusive of accrued interest, if any.
   
(2) $23,024.97 was paid in connection with the initial filing on December 30,
    1996 and $15,179.58 is submitted herewith.
    
   
(3) Represents the number of shares of Common Stock presently issuable upon
    conversion of the Notes being registered hereunder, together with an
    additional indeterminate number of shares as may become issuable upon
    conversion by reason of adjustments in the conversion price. If issued, such
    shares of Common Stock will be issued for no additional consideration and
    therefore no registration fee is required.
    
   
(4) Pursuant to Rule 457(i), no registration fee is required for the shares of
    Common Stock issuable upon conversion of the Notes as such shares will be
    issued for no additional consideration.
    
                             ---------------------
 
    THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.
================================================================================
<PAGE>   2
 
   
PROSPECTUS
    
 
   
DATED             , 1997
    
 
                         QUINTILES TRANSNATIONAL CORP.
   
                                  $126,075,000
    
 
             4.25% CONVERTIBLE SUBORDINATED NOTES DUE MAY 31, 2000
                  (INTEREST PAYABLE ON MAY 31 AND NOVEMBER 30)
 
                                      AND
 
   
          1,523,565 SHARES OF COMMON STOCK, PAR VALUE $.01 PER SHARE,
    
     ISSUABLE UPON CONVERSION OF SUCH 4.25% CONVERTIBLE SUBORDINATED NOTES
                             ---------------------
 
   
    This Prospectus relates to the offer for resale from time to time for the
accounts of holders of Notes named herein (the "Selling Holders") of up to
$126,075,000 aggregate principal amount of 4.25% Convertible Subordinated Notes
due May 31, 2000 (the "Notes") of Quintiles Transnational Corp., a North
Carolina corporation ("Quintiles" or the "Company"), and the 1,523,565 shares of
the Company's Common Stock, par value $.01 per share, (the "Common Stock") that
are issuable upon conversion of the Notes at the initial conversion rate of
12.0846 shares per $1,000 principal amount of Notes (equivalent to a conversion
price of $82.75 per share), subject to adjustment in certain events (the
"Conversion Shares", together with the Notes, the "Offered Securities"). The
Registration Statement (of which this Prospectus is a part) does not cover the
issuance of the Conversion Shares upon conversion of the Notes into shares of
Common Stock. See "Selling Holders" and "Plan of Distribution." None of the
Notes have been converted into Conversion Shares as of the date hereof.
Information concerning the Selling Holders may change from time to time and, to
the extent required, will be set forth in supplements to this Prospectus.
    
 
    The Notes are convertible at any time on or after August 21, 1996 and prior
to the close of business on the maturity date, unless previously redeemed or
repurchased, at a conversion rate of 12.0846 shares per $1,000 principal amount
of Notes (equivalent to a conversion price of $82.75 per share), subject to
adjustment in certain events. See, "Description of Notes -- Conversion Rights."
 
    Interest on the Notes is payable on May 31 and November 30 of each year,
commencing on November 30, 1996. Principal and interest payments will be made
without any deduction for U.S. withholding taxes, except to the extent described
under "Description of Notes -- Payment of Additional Amounts". The Notes are
redeemable (a) in the event of certain developments involving U.S. withholding
taxes or certification requirements (as described under "Description of
Notes -- Redemption -- Redemption for Taxation Reasons"), at a redemption price
of 100% of the principal amount of the Notes to be redeemed, plus accrued
interest to the redemption date, and (b) at the option of the Company, on or
after the close of business on May 31, 1999, in whole or in part, at the
redemption price set forth herein, plus accrued interest to the redemption date.
See "Description of Notes -- Redemption." The Notes are not entitled to any
sinking fund. The Notes will mature on May 31, 2000.
 
    In the event of a Change in Control (as defined), each holder of Notes may
require the Company to repurchase its Notes, in whole or in part, for cash or,
at the Company's option but subject to the satisfaction of certain conditions on
the part of the Company, Common Stock (valued at 95% of the average closing
prices for the five trading days immediately preceding and including the third
trading day prior to the repurchase date), at a repurchase price of 100% of the
principal amount of Notes to be repurchased, plus accrued interest to the
repurchase date. See "Description of Notes -- Repurchase at Option of Holders
Upon a Change in Control."
 
   
    The Notes are unsecured obligations of the Company subordinated in right of
payment to all existing and future Senior Indebtedness (as defined) of the
Company and are effectively subordinated in right of payment to all indebtedness
and other liabilities of the Company's subsidiaries. As of December 31, 1996,
the aggregate amount of outstanding Senior Indebtedness of the Company was
approximately $30,471,000 of which the subsidiaries of the Company had
outstanding approximately $29,205,000 of indebtedness (other than indebtedness
to the Company) and other liabilities. The Indenture will not restrict the
Company or its subsidiaries from incurring additional Senior Indebtedness or
other indebtedness. See "Description of Notes -- Subordination."
    
 
   
    The Notes were issued and sold in a private placement on May 23, 1996 (the
"Original Offering") pursuant to an exemption from the registration requirements
of the Securities Act of 1933, as amended (the "Securities Act"), provided by
Section 4(2) thereof and were resold by the initial purchasers thereof to
qualified institutional buyers pursuant to Rule 144A under the Securities Act
and institutional accredited investors as defined in Rule 501 under the
Securities Act. There is no public market for the Notes. See "Risk Factors." The
Notes issued and sold in reliance on Rule 144A currently are eligible for
trading through the Private Offerings, Resales and Trading through Automatic
Linkages ("PORTAL") System of the National Association of Securities Dealers,
Inc. Notes sold pursuant to the Registration Statement of which this Prospectus
is a part are not expected to remain eligible for trading on the PORTAL System.
The Company does not intend to apply for listing of the Notes on any securities
exchange or for inclusion of the Notes on any automated quotation system. The
Common Stock is traded on the Nasdaq National Market under the symbol "QTRN."
The Conversion Shares will be authorized for listing on the Nasdaq National
Market upon official notice of issuance. On February 16, 1997, the last reported
sale price of the Common Stock on the Nasdaq National Market was $73.5625.
    
 
    The Company has been advised by the Selling Holders that the Selling
Holders, acting as principals for their own account, directly, through agents
designated from time to time, or through brokers, dealers, or underwriters also
to be designated, may sell all or a portion of the Notes or Conversion Shares
which may be offered hereby by them from time to time on terms to be determined
at the time of sale. See "Plan of Distribution." The aggregate proceeds to the
Selling Holders from the sale of Notes and Conversion Shares which may be
offered hereby by the Selling Holders will be the purchase price of such Notes
or Conversion Shares less underwriting discounts and commissions, if any. The
Company is responsible for payment of all other expenses incident to the offer
and sale of the Notes and the Conversion Shares. The Company will not receive
any proceeds from the offering of the Notes or the Conversion Shares.
 
    The Selling Holders and any brokers, dealers, agents or underwriters that
participate with the Selling Holders in the distribution of the Notes or
Conversion Shares may be deemed to be "underwriters" within the meaning of the
Securities Act, in which event any commissions received by such brokers,
dealers, agents or underwriters and any commissions received by such brokers,
dealers, agents or underwriters and any profit on the resale of the Notes or
Conversion Shares purchased by them may be deemed to be underwriting commissions
or discounts under the Securities Act. For information concerning
indemnification arrangements between the Company and the Selling Holders, see,
"Plan of Distribution."
 
    The Company intends that the Registration Statement of which this Prospectus
is a part will remain effective until three years after the latest date of
original issuance of the Notes or such earlier date as of which such
Registration Statement is no longer required for the transfer of the subject
securities. See "Description of Notes -- Registration Rights."
                             ---------------------
 
    SEE "RISK FACTORS" BEGINNING ON PAGE 7 FOR A DISCUSSION OF CERTAIN FACTORS
THAT SHOULD BE CONSIDERED BY PROSPECTIVE PURCHASERS OF THE SECURITIES OFFERED
HEREBY.
                             ---------------------
 
  THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
 EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE SECURITIES
   AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION PASSED UPON THE
ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A
                               CRIMINAL OFFENSE.
<PAGE>   3
 
                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
 
   
     The Company's Annual Report on Form 10-K for the year ended December 31,
1995, the Company's Quarterly Reports on Form 10-Q for the periods ended March
31, 1996, June 30, 1996 and September 30, 1996, the Company's Current Reports on
Form 8-K dated April 16, 1996, October 6, 1996, November 22, 1996 (as amended by
Form 8-K/A on January 16, 1997) and February 7, 1997 filed with the Securities
and Exchange Commission (the "Commission") and the description of the Company's
Common Stock contained in its Registration Statement on Form 8-A as filed with
the Commission on April 11, 1994 are hereby incorporated by reference in this
Prospectus except as superseded or modified herein. In addition, the financial
statements of BRI International, Inc. ("BRI"), included in the Company's
Registration Statement on Form S-4 (File No. 333-12573) as pages F-18 through
F-72, as filed with the Commission on September 24, 1996 and amended on October
15, 1996, are incorporated herein by reference. All documents filed with the
Commission pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities
Exchange Act of 1934, as amended (the "Exchange Act"), after the date of this
Prospectus and prior to the termination of the offering shall be deemed to be
incorporated by reference into this Prospectus and to be a part hereof from the
date of filing of such documents. Any statement contained in any document
incorporated or deemed to be incorporated by reference herein shall be deemed to
be modified or superseded for purposes of this Prospectus to the extent that a
statement contained herein or in any other subsequently filed document which
also is or is deemed to be incorporated by reference herein modifies or
supersedes such statement. Any such statement so modified or superseded shall
not be deemed to constitute a part of this Prospectus except as so modified or
superseded.
    
 
     THIS PROSPECTUS INCORPORATES DOCUMENTS BY REFERENCE WHICH ARE NOT PRESENTED
HEREIN OR DELIVERED HEREWITH. COPIES OF ANY SUCH DOCUMENTS, OTHER THAN EXHIBITS
TO SUCH DOCUMENTS, ARE AVAILABLE WITHOUT CHARGE TO ANY PERSON, INCLUDING ANY
BENEFICIAL OWNER, TO WHOM THIS PROSPECTUS IS DELIVERED UPON WRITTEN OR ORAL
REQUEST TO CORPORATE SECRETARY, QUINTILES TRANSNATIONAL CORP., 4709 CREEKSTONE
DRIVE, RIVERBIRCH BUILDING, SUITE 300, DURHAM, NORTH CAROLINA 27703-8411, OR BY
TELEPHONE AT (919) 941-2000.
 
                             ---------------------
 
                             AVAILABLE INFORMATION
 
     The Company is subject to the informational requirements of the Exchange
Act, and in accordance therewith, files reports, proxy statements and other
information with the Commission. Such reports, proxy statements and other
information filed by the Company may be inspected and copied at the Public
Reference Facilities maintained by the Commission at Room 1024, 450 Fifth
Street, N.W., Judiciary Plaza, Washington, D.C. 20549, and at the Commission's
following regional offices: New York Regional Office, 7 World Trade Center, New
York, New York 10048; and Chicago Regional Office, Citicorp Center, 500 W.
Madison Street, Suite 1400, Chicago, Illinois 60661-2511. Copies of such
material may also be obtained at prescribed rates from the Public Reference
Branch of the Commission at 450 Fifth Street, N.W., Judiciary Plaza, Washington,
D.C. 20549-1004. The Commission maintains a Web site at http://www.sec.gov that
contains reports, proxy and information statements and other information
regarding registrants that file electronically with the Commission, including
the Company. Quotations relating to the Company's Common Stock appear on the
Nasdaq National Market and such reports and other information concerning the
Company can also be inspected at the offices of the Nasdaq Stock Market, 1735 K
Street, N.W., Washington, D.C. 20006-1506.
 
     The Company has filed with the Commission a registration statement on Form
S-3, (the "Registration Statement") under the Securities Act of 1933, as amended
(the "Securities Act"), with respect to the Notes and the Common Stock offered
hereby. This Prospectus does not contain all of the information set forth in the
Registration Statement and the exhibits and schedules thereto, certain portions
of which have been omitted as permitted by the rules and regulations of the
Commission. Statements contained in this Prospectus as to the contents of any
contract or other document referred to are not necessarily complete; and with
respect to each such contract or other document filed as an exhibit to the
Registration Statement, reference is made to such exhibit for a more complete
description of the matters involved, each such statement being qualified in all
respects by such reference. For further information with respect to the Company,
the Notes and the Common Stock, reference is made to the Registration Statement
and exhibits thereto. The information so omitted, including exhibits, may be
obtained from the Commission at its principal office in Washington, D.C. upon
payment of the prescribed fees, or may be inspected without charge at the Public
Reference Facilities of the Commission at 450 Fifth Street, N.W., Judiciary
Plaza, Washington, D.C. 20549-1004.
 
                                        2
<PAGE>   4
 
                                    SUMMARY
 
   
     The following summary information is qualified in its entirety by the more
detailed information and financial statements (including the notes thereto)
included or incorporated by reference in this Prospectus.
    
 
   
     Information contained or incorporated by reference in this Prospectus
contains "forward looking statements" within the meaning of the Private
Securities Litigation Reform Act of 1995, which can be identified by the use of
forward-looking terminology, such as "may," "will," "expect," "anticipate,"
"estimate," "believe" or "continue" or the negative thereof or other variations
thereon or comparable terminology. See "Forward Looking Statements." The matters
set forth under the caption "Risk Factors" in this Prospectus constitute
cautionary statements identifying important factors with respect to such forward
looking statements, including certain risks and uncertainties, that could cause
actual results to differ materially from those in such forward looking
statements.
    
 
                                  THE COMPANY
 
     Quintiles Transnational Corp. (the "Company" or "Quintiles") is a North
Carolina corporation which provides drug development, pharmaceutical sales and
marketing and healthcare consulting services to a range of public and private
sector clients around the world. The Company complements the research and
development departments of pharmaceutical and biotechnology companies by
offering services designed to assure a high quality product for the sponsor
company and reduce drug development time and cost. In addition, the Company's
integrated services and extensive information technology capabilities furnish
clients with broad experience and expertise in global drug development and
provide clients with an outsourced variable-cost alternative to the fixed costs
associated with internal drug development. The Company's core competencies
include clinical research and data management, pharmaceutical sales and
marketing, and consulting on healthcare policy, disease management and
regulatory issues. Quintiles maintains its principal executive office at 4709
Creekstone Drive, Riverbirch Building, Suite 300, Durham, North Carolina,
27703-8411 and its telephone number is (919) 941-2000.
 
   
     In November 1996, the Company acquired BRI International, Inc. ("BRI"), an
international contract research firm based in Arlington, Virginia, in a merger
transaction in which BRI merged with and into a wholly-owned subsidiary of the
Company (the "BRI Merger"). The BRI Merger was accounted for as a pooling of
interests. The Company issued 1,614,862 shares of its Common Stock in the BRI
Merger to the shareholders of BRI and issued options exercisable for 338,693
shares of Common Stock in exchange for outstanding BRI options. BRI specializes
in medical device development and regulatory consulting.
    
 
   
     Also in November 1996, the Company effected a share exchange with Innovex
Limited ("Innovex"), an international contract services organization based in
Marlow, United Kingdom specializing in managing the sales and marketing of drugs
for the pharmaceutical industry. In a transaction accounted for as a pooling of
interests, the Company acquired all of the outstanding Innovex shares in
exchange for 9,214,239 shares of Common Stock and issued options to purchase
786,226 shares of Common Stock in exchange for Innovex stock options. In
connection with the transaction, the Company retired approximately $56.8 million
of Innovex obligations.
    
 
   
     Additional information regarding the November 1996 acquisitions is
contained in the Company's Form 8-K dated October 6, 1996, Form 10-Q for the
period ended September 30, 1996 and Form 8-K dated November 22, 1996 (as amended
by Form 8-K/A on January 16, 1997), as filed with the Commission and
incorporated by reference herein, and the financial statements of BRI
incorporated by reference herein from the Company's Registration Statement on
Form S-4, as filed with the Commission on September 24, 1996 and amended on
October 15, 1996. See "Incorporation of Certain Documents by Reference."
    
                                        3
<PAGE>   5
 
                                  THE OFFERING
 
   
Securities Offered.........  $126,075,000 principal amount of 4.25% Convertible
                             Subordinated Notes due May 31, 2000 (the "Notes"),
                             with interest payable on May 31 and November 30 of
                             each year, commencing on November 30, 1996. This
                             Prospectus also relates to the 1,523,565 shares of
                             Common Stock issuable upon conversion of the Notes
                             at the initial conversion rate of 12.0846 shares
                             per $1,000 principal amount of Notes, subject to
                             adjustment in certain circumstances (the
                             "Conversion Shares," together with the Notes, the
                             "Offered Securities").
    
 
Issuer.....................  Quintiles Transnational Corp., a North Carolina
                             corporation.
 
Conversion Rate............  A conversion rate of 12.0846 shares per U.S.$1,000
                             principal amount of Notes (equivalent to U.S.$82.75
                             per share), subject to adjustment. See "Description
                             of Notes -- Conversion Rights".
 
Form and Denomination......  Upon a transfer in a transaction registered under
                             the Securities Act pursuant to the Registration
                             Rights Agreement (as defined herein), except as
                             otherwise provided in the Indenture, the Notes
                             offered hereby will be represented by a global note
                             in definitive, fully registered form and will be
                             deposited with a custodian for and registered in
                             the name of a nominee of The Depository Trust
                             Company ("DTC") or, upon the request of a Selling
                             Holder of Notes in certificated form, in
                             certificated form registered in the names
                             requested. See "Description of Notes -- Form and
                             Denomination."
 
Convertibility.............  The Notes will be convertible into shares of Common
                             Stock of the Company at any time prior to the close
                             of business on the maturity date, unless previously
                             redeemed or repurchased, at the conversion rate set
                             forth above. Holders of Notes called for redemption
                             will be entitled to convert the Notes to and
                             including, but not after, the date fixed for
                             redemption. The right to convert a Note delivered
                             for repurchase will terminate on the close of
                             business on the repurchase date. See "Description
                             of Notes -- Conversion Rights".
 
Optional Redemption........  Redeemable (a) as described immediately below under
                             "Additional Amounts and Redemption for Taxation
                             Reasons" and (b) at the option of the Company, on
                             or after the close of business on May 31, 1999, at
                             the redemption price set forth herein, plus accrued
                             interest to the redemption date. See "Description
                             of Notes -- Redemption -- Optional Redemption".
 
Additional Amounts and
  Redemption for Taxation
  Reasons..................  The Company will pay Additional Amounts (as defined
                             in "Description of Notes -- Payment of Additional
                             Amounts"), subject to certain exceptions in order
                             that Holders of Notes that are United States Aliens
                             (as defined) receive the full amount of the
                             principal, premium, if any, and interest specified
                             therein (including any amount payable upon a
                             repurchase of the Notes as described immediately
                             below under "Repurchase at Option of Holders Upon
                             Change in Control") without deduction for or on
                             account of U.S. withholding taxes. In the event
                             that the Company must pay such Additional Amounts
                             as a result of a change in law, the Tax Affected
                             Notes (as defined) will be redeemable at the option
                             of the Company, as a whole but not in part,
                                        4
<PAGE>   6
 
                             at 100% of the principal amount thereof, plus any
                             accrued interest to the redemption date (but
                             without reduction for U.S. withholding taxes). The
                             Company shall not be obligated to pay Additional
                             Amounts in respect of payments becoming due on the
                             Notes more than 15 days after the redemption date
                             for such a redemption, except to the extent that
                             the Company's obligation to pay such Additional
                             Amounts does not arise from the change in law that
                             resulted in such redemption.
 
Repurchase at Option of
  Holders Upon Change in
  Control..................  Repurchasable by the Company at the option of the
                             holder upon a Change in Control (as defined under
                             "Description of Notes -- Repurchase at Option of
                             Holders Upon a Change in Control") at 100% of the
                             principal amount thereof, plus accrued interest to
                             the repurchase date. The repurchase price is
                             payable in cash or, at the option of the Company
                             but subject to the satisfaction of certain
                             conditions on the part of the Company, in Common
                             Stock (valued at 95% of the average closing prices
                             of the Common Stock for the five trading days
                             preceding and including the third trading day prior
                             to the repurchase date).
 
   
Subordination..............  Subordinated to present and future Senior
                             Indebtedness (as defined) of the Company. The Notes
                             are also effectively subordinated in right of
                             payment to all indebtedness and other liabilities
                             of the Company's subsidiaries. As of December 31,
                             1996, the aggregate amount of outstanding Senior
                             Indebtedness was approximately $30,471,000 of which
                             the subsidiaries of the Company had approximately
                             $29,205,000 of indebtedness outstanding (other than
                             indebtedness to the Company) and other liabilities.
                             The Indenture will not restrict the incurrence of
                             Senior Indebtedness or other indebtedness by the
                             Company or any of its subsidiaries. See
                             "Description of Notes -- Subordination".
    
 
Events of Default..........  Include: (a) failure to pay principal of or
                             premium, if any, on any Note when due, whether or
                             not such payment is prohibited by the subordination
                             provisions of the Notes and the Indenture; (b)
                             failure to pay any interest (including any
                             Additional Amount) on any Note or coupon when due,
                             continuing for 30 days; (c) failure to provide a
                             Company Notice (as defined); (d) failure to perform
                             any other covenant of the Company in the Indenture,
                             continuing for 60 days after written notice as
                             provided in the Indenture; (e) default in respect
                             of any indebtedness for money borrowed by the
                             Company that results in acceleration of the
                             maturity of an amount in excess of $10,000,000 of
                             indebtedness if such indebtedness is not
                             discharged, or such acceleration is not annulled,
                             within 30 days after written notice as provided in
                             the Indenture, and (f) certain events of
                             bankruptcy, insolvency or reorganization. See
                             "Description of Notes -- Events of Default".
 
Use of Proceeds............  The Company will not receive any proceeds from the
                             sale by the Selling Holders of the Offered
                             Securities. See "Use of Proceeds."
                                        5
<PAGE>   7
 
   
Listing....................  The Notes are currently eligible for trading on the
                             PORTAL System of the National Association of
                             Securities Dealers, Inc. Notes sold pursuant to the
                             Registration Statement, of which this Prospectus
                             forms a part, are not expected to remain eligible
                             for trading on the PORTAL system. The Company's
                             Common Stock is listed on the Nasdaq National
                             Market under the symbol "QTRN," and the Conversion
                             Shares will be authorized for listing on the Nasdaq
                             National Market upon official notice of issuance.
    
 
Governing Law..............  The laws of the State of New York, United States of
                             America.
 
Indenture..................  Dated as of May 17, 1996, between the Company and
                             Marine Midland Bank, as trustee.
                                        6
<PAGE>   8
 
                                  RISK FACTORS
 
   
     In addition to the other information contained or incorporated by reference
in this Prospectus, prospective purchasers should consider the following factors
carefully in evaluating the Company and its business before purchasing the Notes
or Common Stock offered hereby. See also "Forward Looking Statements."
    
 
DEPENDENCE ON CERTAIN INDUSTRIES AND CLIENTS
 
   
     The Company's revenues are highly dependent upon research and development
and sales and marketing expenditures by the pharmaceutical and biotechnology
industries. The Company has benefited to date from the growing tendency of
pharmaceutical and biotechnology companies to engage independent outside
organizations to conduct large clinical research and sales and marketing
projects. The Company's operations could be materially and adversely affected by
a general economic decline in these industries or by any reduction in the
outsourcing of development or sales and marketing expenditures. The Company has
in the past derived, and may in the future derive, a significant portion of its
net revenue from a relatively limited number of major projects or clients. In
1996, 10 clients accounted for approximately 48% of the Company's consolidated
net revenue. As pharmaceutical companies continue to outsource large projects
and studies to fewer full-service global providers, the concentration of
business could increase. The Company is likely to experience such concentration
in 1997 and in future years. The loss of any such client could materially and
adversely affect the Company.
    
 
   
MANAGEMENT OF GROWTH
    
 
   
     The Company has experienced rapid growth over the past 10 years. The
Company believes that its sustained growth places a strain on operational, human
and financial resources. In order to manage its growth, the Company must
continue to improve its operating and administrative systems and to attract and
retain qualified management, professional, scientific and technical personnel.
Foreign operations may involve the additional risks of assimilating differences
in foreign business practices, hiring and retaining qualified personnel, and
overcoming language barriers. The Company has a transnational organizational
structure, comprised of three operating divisions performing complementary
functions with a holding company performing management functions. While this
transnational structure has successfully supported the Company's growth to date,
the Company recently has completed a number of acquisitions, and there can be no
assurance that this structure will continue to be effective. Failure to manage
growth effectively could have a material adverse effect on the Company.
    
 
   
ACQUISITION RISKS
    
 
   
     Acquisitions involve numerous risks, including difficulties and expenses
incurred in connection with the acquisition and the assimilation of the
operations and services of the acquired companies, the diversion of management's
attention from other business concerns, and the potential loss of key employees
of the acquired companies. Acquisitions of foreign companies also may involve
the additional risks of assimilating differences in foreign business practices
and overcoming language barriers. Since February 1996, the Company has completed
four acquisitions, both within the United States and internationally. There can
be no assurance that the Company's past and any future acquisitions will be
successfully integrated into its operations. The Company reviews many
acquisition candidates in the ordinary course of business, and the Company
continually is evaluating new acquisition opportunities. Given the CRO industry
consolidation which is occurring (see, "-- Competition; Industry Consolidation),
the Company expects to continue to evaluate and compete for suitable acquisition
candidates. There can be no assurance that the Company will successfully
complete future acquisitions, nor that acquisitions, if completed, will
contribute favorably to the Company's operations and future financial condition.
Although the Company performs due diligence investigations on each company or
business it seeks to acquire, there may be liabilities which the Company fails
or is unable to discover for which the Company, as a successor owner, may be
liable. The Company generally seeks to minimize its exposure to such liabilities
by obtaining indemnification from each seller, which may be supported by
deferring payment of a portion
    
 
                                        7
<PAGE>   9
 
   
of the purchase price. However, there is no assurance that such
indemnifications, even if obtainable, enforceable and collectible (as to which
there also is no assurance), will be sufficient in amount, scope or duration to
fully offset the potential liabilities arising from the acquisitions.
    
 
   
RISKS RELATING TO CONTRACT SALES SERVICES
    
 
   
     Outsourced contract sales services is a relatively new industry outside the
United Kingdom. The Company believes that the contract sales industry emerged in
the 1980's, primarily in the United Kingdom, because of regulatory cost
containment pressure on pharmaceutical companies. As a result, large
pharmaceutical companies began to outsource their sales and marketing activities
incident to product launch. There is a relatively low level of market
penetration for outsourced sales and marketing services in most other countries,
including the United States. As such, companies in this industry are subject to
all of the risks inherent in a new or emerging industry, including an inability
to attract and retain clients, changes in the regulatory regime, an absence of
an established earnings history, the availability of adequately trained sales
representatives, and additional and unforeseen costs and expenses. There can be
no assurance that the Company will be able to market successfully its contract
sales and marketing services outside the United Kingdom.
    
 
COMPETITION; INDUSTRY CONSOLIDATION
 
   
     The market for the Company's contract research services is highly
competitive, and the Company competes against traditional CROs, the in-house
research and development departments of pharmaceutical companies, universities
and teaching hospitals. In sales and marketing services, the Company competes
against the in-house sales and marketing departments of pharmaceutical companies
and small local contract sales organizations in each country in which it
operates. The Company also competes against consulting firms offering healthcare
consulting services, including boutique firms specializing in the healthcare
industry and the healthcare departments of large firms. Expansion by these
competitors into other areas in which the Company operates could affect the
Company's competitive position. Increased competition may lead to price and
other forms of competition that may affect the Company's margins. Consolidation
within the pharmaceutical industry, as well as a trend by pharmaceutical
companies to limit outsourcing to fewer organizations, has heightened the
competition for contract research services. As a result, consolidation also has
occurred among the providers of contract research services, and several large
full-service providers have emerged, including the Company. If these
consolidation trends continue, they may result in greater competition among the
larger contract research providers for clients and acquisition candidates.
    
 
   
LOSS OR DELAY OF LARGE CONTRACTS; FIXED PRICE NATURE OF CONTRACTS
    
 
   
     Most of the Company's contracts are terminable upon 15-90 days' notice by
the client. Although the contracts typically provide for payment of certain fees
for winding down the study and, in some cases, a termination fee, the loss or
delay of a large contract or the loss or delay of multiple contracts could
adversely affect the Company's future net revenue and profitability. Contracts
may be terminated for a variety of reasons, including the failure of a product
to satisfy safety requirements, unexpected or undesired results of the product,
the client's decision to forego a particular study or insufficient patient
enrollment or investigator recruitment. The Company contracts with investigators
who undertake to recruit large numbers of patients in many of its studies. There
can be no assurance that the Company will always be able to satisfy recruitment
targets, particularly in large studies for which there is little precedent. In
addition, most of the Company's contracts for the provision of its services are
fixed price or fee-for-service subject to a cap. Since the Company's contracts
are predominantly structured in this manner, the Company bears the risk of cost
overruns. Underpricing of contracts or significant cost overruns could have a
material adverse effect on the Company.
    
 
                                        8
<PAGE>   10
 
   
DEPENDENCE ON PERSONNEL
    
 
   
     The Company relies on a number of key executives, including Dennis B.
Gillings, Ph.D., its Chairman of the Board of Directors and Chief Executive
Officer. The Company maintains key man life insurance on Dr. Gillings in the
amount of $3 million. The loss of the services of any key executives could have
a material and adverse effect on the Company. In addition, the Company's
performance depends on its ability to attract and retain qualified management
and professional, scientific and technical operating staff, as well as its
ability to recruit qualified representatives for its contract sales services.
There can be no assurance the Company will be able to continue to attract and
retain qualified personnel.
    
 
POTENTIAL LIABILITY
 
   
     In connection with its provision of contract research services, the Company
contracts with physicians to serve as investigators in conducting clinical
trials to test new drugs on human volunteers. Such testing creates risk of
liability for personal injury to or death of volunteers, particularly to
volunteers with life-threatening illnesses, resulting from adverse reactions to
the drugs administered. Although the Company does not believe it is legally
accountable for the medical care rendered by third party investigators, it is
possible that the Company could be held liable for the claims and expenses
arising from any professional malpractice of the investigators with whom it
contracts or in the event of personal injury to or death of persons
participating in clinical trials. The Company also could be held liable for
errors or omissions in connection with the services it performs. In addition, as
a result of its Phase I clinical trials facilities, the Company could be liable
for the general risks associated with a Phase I facility including, but not
limited to, adverse events resulting from the administration of drugs to
clinical trial participants or the professional malpractice of Phase I medical
care providers. The Company believes that its risks are reduced by contractual
indemnification provisions with clients and investigators, insurance maintained
by clients and investigators and by the Company, various regulatory
requirements, including the use of institutional review boards and the
procurement of each volunteer's informed consent to participate in the study.
The contractual indemnifications generally do not protect the Company against
certain of its own actions such as negligence. The contractual arrangements are
subject to negotiation with clients and the terms and scope of such
indemnification vary from client to client and from trial to trial. The
financial performance of these indemnities is not secured. Therefore, the
Company bears the risk that the indemnifying party may not have the financial
ability to fulfill its indemnification obligations. The Company maintains
professional liability insurance that covers worldwide territories in which the
Company currently does business and includes drug safety issues as well as data
processing errors and omissions. There can be no assurance that the Company will
be able to maintain such insurance coverage on terms acceptable to the Company.
The Company could be materially and adversely affected if it were required to
pay damages or bear the costs of defending any claim outside the scope of or in
excess of a contractual indemnification provision or beyond the level of
insurance coverage or in the event that an indemnifying party does not fulfill
its indemnification obligations.
    
 
   
DEPENDENCE ON GOVERNMENT REGULATION
    
 
   
     The Company's contract research business has benefited from the extensive
governmental regulation of the drug development process, particularly in the
United States. In Europe, the general trend has been toward establishing common
standards for clinical testing of new drugs, leading to changes in the various
requirements currently imposed by each country. The Company believes that the
level of regulation is generally less burdensome outside the United States. From
time to time, legislation is introduced in the U.S. Congress to substantially
modify regulations administered by the Food and Drug Administration governing
the drug approval process. Changes in regulation, in the United States or
elsewhere, including mandatory substitution of generic drugs for patented drugs,
relaxation in the scope of regulatory requirements or the introduction of
simplified drug approval procedures could decrease the business opportunities
available to the Company. In addition, the failure on the part of the Company to
comply with applicable regulations could result in the termination of ongoing
clinical research or sales and
    
 
                                        9
<PAGE>   11
 
   
marketing projects or the disqualification of data for submission to regulatory
authorities, either of which could have a material adverse effect on the
Company.
    
 
   
UNCERTAINTY IN HEALTHCARE INDUSTRY AND POSSIBLE HEALTHCARE REFORM
    
 
   
     The healthcare industry is subject to changing political, economic and
regulatory influences that may affect the pharmaceutical, biotechnology and
medical device industries. Numerous governments have undertaken efforts to
control growing healthcare costs through legislation, regulation and voluntary
agreements with medical care providers and pharmaceutical companies.
Implementation of government healthcare reform may adversely affect research and
development expenditures by pharmaceutical, biotechnology and medical device
companies which could decrease the business opportunities available to the
Company. Management is unable to predict the likelihood of healthcare reform
being enacted or the effects such legislation would have on the Company.
    
 
EXCHANGE RATE FLUCTUATIONS
 
   
     Approximately 56.5%, 59.2% and 57.0% of the Company's net revenue for the
years ended December 31, 1996, 1995 and 1994, respectively, were derived from
the Company's operations outside the United States. The Company's operations and
financial results could be significantly affected by factors associated with
international operations such as changes in foreign currency exchange rates and
uncertainties relative to regional economic circumstances, as well as by other
risks sometimes associated with international operations. Since the revenue and
expenses of the Company's foreign operations are generally denominated in local
currencies, exchange rate fluctuations between such local currencies and the
U.S. dollar will subject the Company to currency translation risk with respect
to the reported results of its foreign operations. Also, the Company may be
subject to foreign currency transaction risks when the Company's service
contracts are denominated in a currency other than the currency in which the
Company incurs expenses related to such contracts. The Company limits its
foreign currency transaction risks through exchange rate collars stated in its
contracts with clients or the Company hedges the transaction risk with foreign
exchange contracts or options. There can be no assurance that the Company will
not experience fluctuations in financial results from its operations outside the
United States, and there can be no assurance the Company will be able to
contractually or otherwise favorably reduce its currency transaction risk
associated with its service contracts.
    
 
   
VARIATION IN QUARTERLY OPERATING RESULTS
    
 
   
     The Company's results of operations have been and can be expected to be
subject to quarterly fluctuations. Quarterly results can fluctuate as a result
of a number of factors, including the timing of start-up expenses for new
offices, acquisitions, the completion or commencement of significant contracts,
changes in the mix of services offered and foreign exchange fluctuations. The
Company believes that quarterly comparisons of its financial results should not
be relied upon as an indication of future performance.
    
 
   
VOLATILITY OF STOCK PRICE
    
 
   
     The market price of the Company's Common Stock has been and may continue to
be subject to wide fluctuations in response to variations in operating results
from quarter to quarter, changes in earnings estimates by analysts, market
conditions in the industry and general economic conditions.
    
 
SUBORDINATION
 
     The obligations of the Company under the Notes are subordinate to all
present and future Senior Indebtedness of the Company and pari passu with
obligations to, or rights of, the Company's general unsecured creditors. As a
result, upon any acceleration of the Notes or payment or distribution of the
assets of the Company to creditors upon any dissolution, winding up, liquidation
or reorganization, marshalling of assets, assignment for the benefit of
creditors, or in bankruptcy, insolvency, receivership
 
                                       10
<PAGE>   12
 
   
or other similar proceedings of the Company, all principal, premium, if any, and
interest or other amounts due on all Senior Indebtedness must be paid in full
before the holders of Notes are entitled to receive any payment, and there may
not be sufficient assets remaining to pay amounts due on any or all of the Notes
then outstanding. The Notes are also effectively subordinated in right of
payment to all indebtedness and other liabilities of the Company's subsidiaries.
As of December 31, 1996, the aggregate amount of outstanding Senior Indebtedness
was approximately $30,471,000 of which the subsidiaries of the Company had
approximately $29,205,000 of indebtedness outstanding (other than indebtedness
to the Company) and other liabilities. The Indenture does not limit the
Company's or its subsidiaries' ability to incur Senior Indebtedness or any other
indebtedness. See "Description of Notes -- Subordination."
    
 
ABSENCE OF TRADING MARKET FOR NOTES
 
     Prior to this offering, there has been no trading market for the Notes
other than through the PORTAL System. There can be no assurance as to the
liquidity of any such market that may develop, the ability of the holders of
Notes to sell such securities, the price at which the holders of Notes would be
able to sell such securities or whether a trading market, if it develops, will
continue. If such a market were to exist, the Notes could trade at prices higher
or lower than their principal amount, depending on many factors, including
prevailing interest rates, the market for similar securities and the operating
results of the Company. In addition, Notes sold pursuant to the Registration
Statement, of which this Prospectus forms a part, are not expected to remain
eligible for trading on the PORTAL system.
 
                       RATIO OF EARNINGS TO FIXED CHARGES
 
   
     The following table sets forth the Company's ratio of earnings to fixed
charges for each of the five fiscal years in the period ended December 31, 1996.
Earnings used in computing the ratio of earnings to fixed charges have been
calculated by adding fixed charges to income (loss) before taxes. Fixed charges
consist of interest costs, whether expensed or capitalized, the estimated
interest component of rental expenses, and amortization of debt discounts and
issue costs. All periods presented have been restated to include the effects of
the Company's pooling of interest transactions effected with BRI and Innovex in
November 1996.
    
 
   
<TABLE>
<CAPTION>
                                                            YEAR ENDED DECEMBER 31,
                                                        --------------------------------
                                                        1992   1993   1994   1995   1996
                                                        ----   ----   ----   ----   ----
<S>                                                     <C>    <C>    <C>    <C>    <C>
Ratio of Earnings to Fixed Charges....................  4.26   3.29   4.86   5.57   2.46(1)
                                                        ====   ====   ====   ====   ====
</TABLE>
    
 
- ---------------
 
   
(1) The ratio of earnings to fixed charges would be 4.85 if the computation of
     the ratio were to exclude non-recurring charges for transaction and
     restructuring costs of $27.847 million in 1996 from pre-tax income.
    
 
                                       11
<PAGE>   13
 
                                  THE COMPANY
 
     Quintiles Transnational Corp. (the "Company" or "Quintiles") is a North
Carolina corporation which provides drug development, pharmaceutical sales and
marketing and healthcare consulting services to a range of public and private
sector clients around the world. The Company complements the research and
development departments of pharmaceutical and biotechnology companies by
offering services designed to assure a high quality product for the sponsor
company and reduce drug development time and cost. In addition, the Company's
integrated services and extensive information technology capabilities furnish
clients with broad experience and expertise in global drug development and
provide clients with an outsourced variable-cost alternative to the fixed costs
associated with internal drug development. The Company's core competencies
include clinical research and data management, pharmaceutical sales and
consulting on healthcare policy, disease management and regulatory issues.
Quintiles maintains its principal executive office at 4709 Creekstone Drive,
Riverbirch Building, Suite 300, Durham, North Carolina, 27703-8411 and its
telephone number is (919) 941-2000.
 
   
     In November 1996, the Company acquired BRI, an international contract
research firm based in Arlington, Virginia, in a merger transaction in which BRI
merged with and into a wholly-owned subsidiary of the Company. The BRI Merger
was accounted for as a pooling of interests. The Company issued 1,614,862 shares
of its Common Stock in the BRI Merger to the shareholders of BRI and issued
options exercisable for 338,693 shares of Common Stock in exchange for
outstanding BRI options. BRI specializes in medical device development and
regulatory consulting.
    
 
   
     Also in November 1996, the Company effected a share exchange with Innovex,
an international contract services organization based in Marlow, United Kingdom,
specializing in managing the sales and marketing of drugs for the pharmaceutical
industry. In a transaction accounted for as a pooling of interests, the Company
acquired all of the outstanding Innovex shares in exchange for 9,214,239 shares
of its Common Stock and issued options to purchase 786,226 shares of Common
Stock in exchange for Innovex options. In connection with the transaction, the
Company retired approximately $56.8 million of Innovex obligations.
    
 
   
     Additional information regarding the November 1996 acquisitions is
contained in the Company's quarterly report on Form 10-Q for the period ended
September 30, 1996 and Current Reports on Form 8-K dated October 11, 1996 and
November 22, 1996 (as amended by Form 8-K/A on January 16, 1997) as filed with
the Commission and incorporated by reference herein and the financial statements
of BRI incorporated by reference herein from pages F-18 through F-72 of the
Company's Registration Statement on Form S-4 (File No. 333-12573), as filed with
the Commission on September 24, 1996 and amended on October 15, 1996. See
"Incorporation of Certain Documents by Reference."
    
 
                                USE OF PROCEEDS
 
     The Selling Holders will receive all of the proceeds from the sale of the
Offered Securities. The Company will receive no proceeds from such sales.
 
                                       12
<PAGE>   14
 
                                SELLING HOLDERS
 
   
     The Notes and Conversion Shares that may be offered pursuant to this
Prospectus will be offered by the Holders listed in the table below or their
transferees identified in supplements to this Prospectus (the "Selling
Holders"). The following table sets forth information with respect to the
Selling Holders and the principal amount of Notes and number of shares of Common
Stock beneficially owned and that may be offered by each such Selling Holder
pursuant to this Prospectus, all as of February 11, 1997.
    
 
   
<TABLE>
<CAPTION>
                                                           PRINCIPAL       COMMON
                                            PRINCIPAL      AMOUNT OF        STOCK       COMMON
                                              AMOUNT         NOTES          OWNED        STOCK
                                             OF NOTES       OFFERED       PRIOR TO      OFFERED
             SELLING HOLDER                   OWNED          HEREBY      OFFERING(1)   HEREBY(2)
             --------------                ------------   ------------   -----------   ---------
<S>                                        <C>            <C>            <C>           <C>
AIM Balanced Fund........................  $  1,200,000   $  1,200,000       14,501       14,501
AIM Charter Fund.........................    12,000,000     12,000,000      145,015      145,015
AIM V.I. Growth & Income Fund............       500,000        500,000        6,042        6,042
Allstate Insurance Company...............     2,000,000      2,000,000       24,169       24,169
Aragon Investments, Ltd. ................     1,000,000      1,000,000       19,184       12,084
Bancroft Convertible Fund, Inc. .........       500,000        500,000        6,042        6,042
Bankers Trust International PLC..........     5,415,000      5,415,000       65,438       65,438
Capital World Growth and Income Fund,
  Inc. ..................................    10,000,000     10,000,000      120,846      120,846
Catholic Mutual Series...................       350,000        350,000        4,229        4,229
CFW-C, L.P. .............................     3,000,000      3,000,000       36,253       36,253
Cincinnati Bell Telephone Convertible
  Value Fund.............................       530,000        530,000        6,404        6,404
Colonial Penn Insurance..................       100,000        100,000        1,208        1,208
Colonial Penn Life Insurance Co. ........       100,000        100,000        1,208        1,208
Columbia/HCA Hospital Corporation........       640,000        640,000        7,734        7,734
David Lipscomb University................        60,000         60,000          725          725
Declaration of Trust for the Defined
  Benefit Plan of ICI American Holdings,
  Inc. ..................................       410,000        410,000        4,954        4,954
Declaration of Trust for the Defined
  Benefit Plans of ZENECA Holdings,
  Inc. ..................................       270,000        270,000        3,262        3,262
Delaware State Employees' Retirement
  Fund...................................     1,340,000      1,340,000       16,193       16,193
Delta Airlines Master Trust..............     1,175,000      1,175,000       14,199       14,199
Ellsworth Convertible Growth and Income
  Fund, Inc. ............................       500,000        500,000        6,042        6,042
Equitable Life Assurance Separate
  Account -- Balanced....................       115,000        115,000        1,389        1,389
Equitable Life Assurance Separate
  Account -- Convertibles................     2,200,000      2,200,000       26,586       26,586
First Hawaiian Bank Custodian Hotel
  Industry -- ILWU Pension Plan..........       100,000        100,000        1,208        1,208
First Hawaiian Bank Custodian Hotel Union
  Pension Trust Fund.....................       280,000        280,000        3,383        3,383
General Motors Employees Domestic Group
  Trust..................................     3,600,000      3,600,000       43,504       43,504
General Motors Salaried Employees
  Convertible Fund.......................     4,730,000      4,730,000       57,160       57,160
Gershow Partners.........................       325,000        325,000        3,927        3,927
Glen Eagles Fund.........................       325,000        325,000        3,927        3,927
The HCA Foundation.......................       225,000        225,000        2,719        2,719
Highbridge Capital Corporation...........     3,500,000      3,500,000       42,296       42,296
Hillside Capital Incorporated Corporate
  Account................................       120,000        120,000        1,450        1,450
</TABLE>
    
 
                                       13
<PAGE>   15
   
<TABLE>
<CAPTION>
                                                           PRINCIPAL       COMMON
                                            PRINCIPAL      AMOUNT OF        STOCK       COMMON
                                              AMOUNT         NOTES          OWNED        STOCK
                                             OF NOTES       OFFERED       PRIOR TO      OFFERED
             SELLING HOLDER                   OWNED          HEREBY      OFFERING(1)   HEREBY(2)
             --------------                ------------   ------------   -----------   ---------
<S>                                        <C>            <C>            <C>           <C>
Hudson River Trust Balanced Portfolio....       790,000        790,000        9,546        9,546
Hudson River Trust Growth & Income.......       505,000        505,000        6,102        6,102
Hudson River Trust Growth Investors......       690,000        690,000        8,338        8,338
Hughes Aircraft Company Master Retirement
  Trust..................................       925,000        925,000       11,178       11,178
JP Morgan Securities Inc. ...............    18,970,000     18,970,000      229,244      229,244
Mainstay Convertible Fund................     1,800,000      1,800,000       21,752       21,752
Massachusetts Mutual Life Insurance
  Company................................       450,000        450,000        5,438        5,438
Medical Malpractice Insurance
  Association............................       110,000        110,000        1,329        1,329
Memphis Light, Gas & Water...............       860,000        860,000       10,392       10,392
Merrill Lynch, Pierce, Fenner & Smith,
  Custodian FPO Dr. Eric Vander Elst
  IRRA(3)................................       750,000        250,000       80,488        3,021
Merrill Lynch, Pierce, Fenner & Smith
  Inc. ..................................     1,000,000      1,000,000       12,084       12,084
Merrill Lynch Capital Markets PLC........     1,550,000      1,550,000       18,731       18,731
NB Convertible Arbitrage Partners,
  L.P. ..................................     3,000,000      3,000,000       36,253       36,253
New York Life Separate Account No. 7.....       500,000        500,000        6,042        6,042
North Dakota State Land Department.......       270,000        270,000        3,262        3,262
OCM Convertible Limited Partnership......        75,000         75,000          906          906
OCM Convertible Trust....................     1,680,000      1,680,000       20,302       20,302
Palladin Partners........................       325,000        325,000        3,927        3,927
Paloma Securities L.L.C. ................     2,000,000      2,000,000       24,169       24,169
Partner Reinsurance Company Ltd..........       350,000        350,000        4,229        4,229
Ramius Fund..............................       825,000        825,000        9,969        9,969
Sage Capital.............................     1,600,000      1,600,000       19,335       19,335
Shepherd Investments International,
  Ltd....................................     3,675,000      3,675,000       44,410       44,410
SMM Co BV................................     8,590,000      8,590,000      103,806      103,806
Societe Generale Securities Corp. .......     2,250,000      2,250,000       27,190       27,190
Stark International......................     3,525,000      3,525,000       42,598       42,598
State of Connecticut Combined Investment
  Funds..................................     1,480,000      1,480,000       17,885       17,885
State of Michigan Employees Retirement
  Fund...................................     1,215,000      1,215,000       14,682       14,682
TCW Convertible Securities Fund..........     2,750,000      2,750,000       33,232       33,232
TCW Convertible Strategy Fund............       910,000        910,000       10,996       10,996
TCW Convertible Value Fund...............       995,000        995,000       12,024       12,024
TCW Convertible Value L.P. ..............       320,000        320,000        3,867        3,867
TCW/DW Income & Growth Fund..............       305,000        305,000        3,685        3,685
Teepak, Inc. Master Retirement Trust.....        40,000         40,000          483          483
ThermoElectron Balanced Investment
  Fund...................................       220,000        220,000        2,658        2,658
TQA Vantage Fund, Ltd....................     1,450,000      1,450,000       17,522       17,522
Vanguard Convertible Securities Fund,
  Inc....................................       415,000        415,000        5,015        5,015
Van Kampen American Capital Harbor Fund..     2,500,000      2,500,000       30,211       30,211
ZaZove Convertible Fund, L.P. ...........       300,000        300,000        3,625        3,625
                                           ------------   ------------    ---------    ---------
     Total...............................  $126,575,000   $126,075,000    1,608,102    1,523,535(4)
                                           ============   ============    =========    =========
</TABLE>
    
 
                                       14
<PAGE>   16
 
- ---------------
 
(1) Includes the shares of Common Stock into which the full amount of Notes held
     by the Selling Holder are convertible at the initial conversion rate. The
     Conversion Rate and the number of shares of Common Stock issuable upon
     conversion of the Notes are subject to adjustment under certain
     circumstances. See "Description of Notes -- Conversion Rights."
     Accordingly, the number of shares of Common Stock issuable upon conversion
     of the Notes may vary from time to time.
(2) Assumes conversion into Common Stock at the initial conversion rate of the
     Notes held by the Selling Holder and offered hereby. The Conversion Rate
     and the number of shares of Common Stock issuable upon conversion of the
     Notes is subject to adjustment under certain circumstances. See
     "Description of Notes -- Conversion Rights." Accordingly, the number of
     shares of Common Stock issuable upon conversion of the Notes may vary from
     time to time. Fractional shares will not be issued upon conversion of the
     Notes; cash will be paid in lieu of fractional shares, if any.
   
(3) Includes 59,404 shares of Common Stock beneficially owned by Dr. Vander
     Elst, 7,135 shares issuable upon the exercise of options held by Dr. Vander
     Elst which are exercisable within 60 days of February 5, 1997 and 4,886
     shares held in the Company's Employee Stock Ownership Plan for Dr. Vander
     Elst's account. Dr. Vander Elst is Corporate Vice President and Chief
     Medical Officer of the Company.
    
   
(4) Due to rounding, the total of this column may not exactly equal the
     aggregate number of shares of Common Stock issuable upon conversion of the
     Notes at the initial conversion rate.
    
 
     The preceding table was prepared based on information furnished to the
Company by the Depository Trust Company ("DTC"), Marine Midland Bank, trustee
under the Indenture, and by or on behalf of the Selling Holders.
 
   
     Other than as a result of the ownership of Notes or as otherwise described
above, none of the Selling Holders listed above had any material relationship
with the Company within the three year period ending on the date of this
Prospectus.
    
 
     Because the Selling Holders may offer all or some of the Notes that they
hold and/or Conversion Shares pursuant to the offering contemplated by this
Prospectus, and because there are currently no agreements, arrangements or
understandings with respect to the sale of any of the Notes or Conversion Shares
offered hereby by the Selling Holders, it is not possible to provide an estimate
of the principal amount of Notes or Common Stock that will be held by the
Selling Holders after completion of this offering. In addition, the Selling
Holders identified above may have sold, transferred or otherwise disposed of all
or a portion of their Offered Securities in transactions exempt from the
registration requirements of the Securities Act. See "Plan of Distribution."
 
                              PLAN OF DISTRIBUTION
 
     The Offered Securities are being registered to permit public secondary
trading of the Notes, and the Conversion Shares upon conversion thereof, by the
holders thereof from time to time after the date of this Prospectus. The Company
has agreed, among other things, to bear all expenses other than underwriting
discounts and selling commissions and fees in connection with the registration
and sale of the Offered Securities.
 
     The Company will not receive any of the proceeds from this offering. The
Offered Securities may be sold from time to time by or for the account of any of
the Selling Holders or by their pledgees, donees, transferees or other
successors in interest. The Offered Securities may be sold directly to
purchasers in negotiated transactions; by or through brokers or dealers in
ordinary brokerage transactions or in transactions in which the broker solicits
purchasers; in block trades in which the broker or dealer will attempt to sell
the Offered Securities as agent but may position and resell a portion of the
block as principal; or in transactions in which a broker or dealer purchases as
principal for resale for its own account. Offers and sales of the Offered
Securities may not occur through an underwritten offering unless the Company, in
its discretion, consents in advance. Sales may be effected in one or more
transactions (i) on the Nasdaq National Market, in other over-the counter
markets, or on any stock exchange on which
 
                                       15
<PAGE>   17
 
the Offered Securities may be listed or quoted at the time of sale; (ii) in
transactions otherwise than on such exchanges or over-the-counter markets; (iii)
through the writing of options (whether such options are listed on a stock
exchange or otherwise) on, or settlement of short sells of, Common Stock; (iv)
by means of a combination of the above; or (v) otherwise. Any of such
transactions may be effected at market prices prevailing at the time of sale, at
prices related to such prevailing market prices, at varying prices determined at
the time of sale or at negotiated or fixed prices, in each case as determined by
the Selling Holder.
 
     Any brokers, dealers, underwriters or agents may receive compensation in
the form of discounts, concessions or commissions from the Selling Holder or
from the purchasers of the securities for whom they may act as agent, which
discounts, concessions or commissions may be in excess of those customary in the
types of transactions involved. Such brokers, dealers, underwriters or agents,
as the case may be, and the Selling Holders may be deemed to be "underwriters"
within the meaning of the Securities Act in connection with such sales, and any
profit on the sale of the Offered Securities and any discounts, concessions or
commissions received by such broker, dealer, underwriter or agent may be deemed
to be underwriting discounts and commissions under the Securities Act.
 
     To the extent required, the aggregate principal amount of Notes and number
of shares of Common Stock to be sold hereby, the name of the Selling Holder, the
purchase price, the name of any such agent, dealer or underwriter and any
applicable commissions, discounts or other terms constituting compensation with
respect to a particular offer will be set forth in an accompanying Prospectus
Supplement.
 
   
     The Selling Holders and any other person who participates in a distribution
of the Notes or shares of Common Stock will be subject to applicable provisions
of the Exchange Act and the rules and regulations thereunder, including Rules
10b-2, 10b-6 and 10b-7, or their successors, which provisions may limit the
timing of purchases and sales of Notes or shares of Common Stock by the Selling
Holders. The applicable provisions of the Exchange Act and the rules and
regulations thereunder may affect the marketability of the Notes and shares of
Common Stock and the ability of any person to engage in market making activities
for the Notes or shares of Common Stock.
    
 
     To the Company's knowledge, there currently are no plans, arrangements or
understandings between any Selling Holder and any broker, dealer or underwriter
regarding the sale of the Offered Securities by the Selling Holders. There can
be no assurance that any Selling Holder will sell any or all of the Offered
Securities hereunder or that any Selling Holder will not transfer, devise or
give such Offered Securities by other means not described herein.
 
     The outstanding Common Stock is listed for trading on the Nasdaq/NMS, and
the shares of Common Stock issuable upon conversion of the Notes will be
authorized for listing on the Nasdaq/NMS upon official notice of issuance. The
Notes currently are eligible for trading in the PORTAL market of the National
Association of Securities Dealers, Inc. Notes sold pursuant to the Registration
Statement, of which this Prospectus forms a part, are not expected to remain
eligible for trading in the PORTAL System. The Company does not intend to apply
for listing of the Notes on any securities exchange or for inclusion of the
Notes on any automated quotation system. There is no assurance as to the
development or liquidity of any trading market that may develop for the Notes.
 
     The Company and the Selling Holders have agreed to indemnify each other
against certain liabilities arising under the Securities Act.
 
                                       16
<PAGE>   18
 
                              DESCRIPTION OF NOTES
 
     The Notes were issued under an Indenture, dated as of May 17, 1996 (the
"Indenture"), between the Company and Marine Midland Bank, as Trustee (the
"Trustee"), filed as an exhibit to the Registration Statement of which this
Prospectus forms a part. Wherever particular defined terms of the Indenture
(including the Notes and the various forms thereof) are referred to, such
defined terms are incorporated herein by reference (the Notes and various terms
relating to the Notes being referred to in the Indenture as "Securities").
References in this section to the "Company" are solely to Quintiles
Transnational Corp. and not its subsidiaries. The following summaries of certain
provisions of the Indenture do not purport to be complete and are subject to,
and are qualified in their entirety by reference to, the detailed provisions of
the Notes and the Indenture, including the definitions therein of certain terms.
Section references below are references to Sections of the Indenture.
 
GENERAL
 
   
     The Notes are unsecured subordinated obligations of the Company, are
limited to U.S.$143,750,000 aggregate principal amount, of which $126,075,000
principal amount are being registered hereunder, will mature on May 31, 2000 and
be payable at a price of 100% of the principal amount thereof. The Notes bear
interest at the rate of 4.25% per annum from May 23, 1996, payable semiannually
on May 31 and November 30 of each year, commencing on November 30, 1996.
Interest payable per $1,000 principal amount of Notes for the period from May
23, 1996 to November 30, 1996 was U.S.$22.19. (sec.sec. 3.1 and 3.7)
    
 
     The Notes are convertible into Common Stock initially at the conversion
rate of 12.0846 shares per $1,000 principal amount of Notes (equivalent to a
conversion price of $82.75 per share), subject to adjustment upon the occurrence
of certain events described under "-- Conversion Rights", at any time prior to
the close of business on the maturity date, unless previously redeemed or
repurchased. (sec. 12.1) None of the Notes have been converted into Conversion
Shares as of the date hereof.
 
     The Notes are redeemable (a) in the event of certain developments involving
U.S. withholding taxes or certification requirements as described below under
"-- Redemption -- Redemption for Taxation Reasons", at a redemption price of
100% of the principal amount of the Notes to be redeemed, plus accrued interest
to the redemption date and (b) at the option of the Company, on or after the
close of business on May 31, 1999, in whole or in part, at the redemption price
set forth below under "-- Redemption -- Optional Redemption", plus accrued
interest to the redemption date. (sec. 2.2)
 
     The Company issued and sold $143,750,000 principal amount of the Notes on
May 23, 1996 to Goldman Sachs International and Smith Barney Inc. (together, the
"Initial Purchasers") in a private placement exempt from the registration
provisions of the Securities Act (the "Original Offering"). The Initial
Purchasers have advised the Company that they resold the Notes in transactions
exempt from the registration provisions of the Securities Act to Qualified
Institutional Buyers in reliance on Rule 144A under the Securities Act ("Rule
144A Notes"), in transactions in reliance on Regulation S ("Regulation S Notes")
and to a limited number of Institutional Accredited Investors (as defined) in
transactions exempt from registration under the Securities Act not made in
reliance on Rule 144A or Regulation S ("Regulation D Notes"). Pursuant to a
Registration Rights Agreement entered by and among the Company and the Initial
Purchasers at the time of the Original Offering (the "Registration Rights
Agreement"), Notes sold in compliance with Regulation S are not eligible for
inclusion in the Registration Statement, of which this Prospectus forms a part.
See "-- Registration Rights."
 
FORM AND DENOMINATION
 
     Upon a transfer in a transaction registered under the Securities Act
pursuant to the Registration Rights Agreement, the Notes offered hereby will be
represented by (i) a global Note (the "Unrestricted Global Note") in definitive,
fully registered form, without interest coupons, and which will, as of the date
hereof, be deposited with the Trustee as custodian for DTC and registered in the
name of a nominee of
 
                                       17
<PAGE>   19
 
DTC or (ii) upon the request of a Selling Holder of Notes in certificated (i.e.
non-global) form, in certificated form registered in the names requested.
 
     Upon each sale by a Selling Holder of Notes or the Conversion Shares, as
the case may be, offered hereby, such Selling Holder will be required to deliver
a Notice (the "Notice") of such sale to the Trustee and the Company. The Notice
will, among other things, identify the sale as a sale pursuant to the
Registration Statement of which this Prospectus forms a part, certify that the
prospectus delivery requirements, if any, of the Securities Act have been
satisfied, and certify that the Selling Holder and the aggregate principal
amount of Notes or the number of Conversion Shares owned by such holder are
identified in the Prospectus in accordance with the applicable rules and
regulations under the Securities Act. A copy of the form of Notice is included
herein in Appendix A. Additional copies are available upon request to Corporate
Secretary, Quintiles Transnational Corp., 4709 Creekstone Drive, Riverbirch
Building, Suite 300, Durham, North Carolina 27703-8411, telephone (919)
941-2000.
 
     Upon receipt by the Trustee of the Notice relating to a sale of the Notes,
an appropriate adjustment will be made to reflect a decrease in the principal
amount of the Restricted Global Note (as defined below) or the cancellation of a
Note in certificated form upon the transfer thereof, and a corresponding
increase in the principal amount of the Unrestricted Global Note (or upon the
request of a Selling Holder of Notes in certificated form, the authentication
and delivery of a Note in certificated form).
 
     The provisions below describe the form and denomination of the Notes
offered hereby in connection with their original offering in a transaction or
transactions not required to be registered under the Securities Act.
 
     Rule 144A Notes are represented by a Note in registered global form without
interest coupons (the "Restricted Global Note", where the context requires,
together with the Unrestricted Global Note, the "Global Notes") which has been
deposited with the Trustee as custodian for DTC and registered in the name of a
nominee of DTC.
 
     Owners of beneficial interests in any Global Note will hold such interests
pursuant to the procedures and practices of DTC and must exercise any rights in
respect of their interests (including any right to convert, exchange or require
repurchase of their interests) in accordance with those procedures and
practices. Such beneficial owners will not be Holders, and will not be entitled
to any rights under any Note or the Indenture, with respect to any Global Note,
and the Company and the Trustee, and any of their respective agents, may treat
DTC as the Holder and owner of any Global Note. See "-- Depository Procedures
with Respect to Global Notes".
 
     Except as set forth below, the Global Notes may be transferred, in whole
and not in part, only to another nominee of DTC or to a successor of DTC or its
nominee. Beneficial interests in the Global Notes may not be exchanged for Notes
in certificated form except in the limited circumstances described below. See
" -- Transfer, Exchange and Withdrawal -- Exchange of Interests in Global Notes
for Certificated Notes".
 
     Regulation D Notes were initially issued in the form of Notes in
certificated (i.e. non-global) form. Regulation D Notes were issued in minimum
denominations of $1,000 and integral multiples thereof. Regulation D Notes
initially issued in certificated form may not be exchanged for beneficial
interests in any Global Note, except in limited circumstances.
 
   
     Rule 144A Notes (including beneficial interests in the Restricted Global
Note) and Regulation D Notes are subject to certain restrictions on transfer and
bear a restrictive legend. In addition, transfer of beneficial interests in the
Global Notes will be subject to the applicable rules and procedures of DTC and
its Participants (as defined below) or Indirect Participants (as defined below),
which may change from time to time.
    
 
     For a description of the depository procedures with respect to the Global
Notes, see "-- Depository Procedures with Respect to Global Notes".
 
                                       18
<PAGE>   20
 
CONVERSION RIGHTS
 
     The Holder of any Note will have the right, at the Holder's option, to
convert any portion of the principal amount of any Note that is an integral
multiple of $1,000 into shares of Common Stock at any time prior to the close of
business on the maturity date, unless previously redeemed or repurchased, at a
conversion rate of 12.0846 shares of Common Stock per $1,000 principal amount of
Notes (the "Conversion Rate") (equivalent to a conversion price of $82.75 per
share of Common Stock) subject to adjustment as described below. The right to
convert a Note called for redemption or delivered for repurchase will terminate
at the close of business on the Redemption Date for such Note or the Repurchase
Date, as the case may be. (sec. 12.1)
 
     The right of conversion attaching to any Note may be exercised by the
Holder by delivering the Note at the specified office of a Conversion Agent,
accompanied by a duly signed and completed notice of conversion. Such notice of
conversion can be obtained at the office of the Trustee at its Corporate Trust
Offices in New York City and the Conversion Agent in Luxembourg and London. The
conversion date will be the date on which the Note and the duly signed and
completed notice of conversion are so delivered. As promptly as practicable on
or after the conversion date, the Company will issue and deliver to the Trustee
a certificate or certificates for the number of full shares of Common Stock
issuable upon conversion, together with payment in lieu of any fraction of a
share; such certificate will be sent by the Trustee to the appropriate
Conversion Agent for delivery to the Holder. Such shares of Common Stock
issuable upon conversion of the Notes, in accordance with the provisions of the
Indenture, will be fully paid and nonassessable and will rank pari passu with
the other shares of Common Stock of the Company outstanding from time to time.
Any Note surrendered for conversion during the period from the close of business
on any Regular Record Date next preceding any Interest Payment Date to the
opening of business on such Interest Payment Date (except Notes (or portions
thereof) called for redemption on a Redemption Date or which are repurchasable
on a Repurchase Date occurring, in either case, within such period) must be
accompanied by payment of an amount equal to the interest payable on such
Interest Payment Date on the principal amount of Notes being surrendered for
conversion. The interest so payable on such Interest Payment Date with respect
to any Note (or portion thereof, if applicable) which has been called for
redemption on a Redemption Date, or which may be repurchased on a Repurchase
Date, occurring, in either case, during the period from the close of business on
any Record Date next preceding any Interest Payment Date to the opening of
business on such Interest Payment Date, which Note (or portion thereof, if
applicable) is surrendered for conversion during such period, shall be paid to
the Holder of such Note being converted in an amount equal to the interest that
would have been payable on such Note if such Note had been converted as of the
close of business on such Interest Payment Date. The interest so payable on such
Interest Payment Date in respect of any Note (or portion thereof, as the case
may be) which has not been called for redemption on a Redemption Date, or is not
eligible for repurchase on a Repurchase Date, occurring, in either case, during
the period from the close of business on any Record Date next preceding any
Interest Payment Date to the opening of business on such Interest Payment Date,
which Note (or portion thereof, as the case may be) is surrendered for
conversion during such period, shall be paid to the Holder of such Note as of
such Regular Record Date. Interest payable in respect of any Note surrendered
for conversion or repurchase on or after an Interest Payment Date shall be paid
to the Holder of such Note as of the next preceding Regular Record Date,
notwithstanding the exercise of the right of conversion. As a result of the
foregoing provisions, except as provided above, Holders that surrender Notes for
conversion on a date that is not an Interest Payment Date will not receive any
interest for the period from the Interest Payment Date next preceding the date
of conversion to the date of conversion or for any later period, even if the
Notes are surrendered after a notice of redemption (except for the payment of
interest on Notes called for redemption on a Redemption Date or repurchasable on
a Repurchase Date between a Regular Record Date and the Interest Payment Date to
which it relates, as provided above). No other payment or adjustment for
interest, or for any dividends in respect of Common Stock, will be made upon
conversion. Holders of Common Stock issued upon conversion will not be entitled
to receive any dividends payable to holders of Common Stock as of any record
time or date before the close of business on the conversion date. No fractional
shares will be issued upon conversion but, in lieu thereof, an appropriate
amount will be paid in cash by the Company
 
                                       19
<PAGE>   21
 
based on the market price of Common Stock at the close of business on the day of
conversion. (sec.sec. 2.2, 3.7, 12.2 and 12.3)
 
     A Holder delivering a Note for conversion will not be required to pay any
taxes or duties in respect of the issue or delivery of Common Stock on
conversion but will be required to pay any tax or duty which may be payable in
respect of any transfer involved in the issue or delivery of the Common Stock in
a name other than that of the Holder of the Note. Certificates representing
shares of Common Stock will not be issued or delivered unless all taxes and
duties, if any, payable by the Holder have been paid. (sec.sec. 12.2 and 12.8)
 
     The Conversion Rate is subject to adjustment in certain events, including,
without duplication: (a) dividends (and other distributions) payable in Common
Stock, (b) the issuance to all holders of Common Stock of rights, options or
warrants entitling them to subscribe for or purchase Common Stock at less than
the then Current Market Price of such Common Stock (determined as provided in
the Indenture) as of the record date for shareholders entitled to receive such
rights, options or warrants, (c) subdivisions, combinations and
reclassifications of Common Stock, (d) distributions to all holders of Common
Stock of evidences of indebtedness of the Company, shares of capital stock, cash
or assets (including securities, but excluding those dividends, rights, options,
warrants and distributions referred to above, dividends and distributions paid
exclusively in cash and in mergers and consolidations to which the next
succeeding paragraph applies), (e) distributions consisting exclusively of cash
(excluding any cash portion of distributions referred to in (d) above, or cash
distributed upon a merger or consolidation to which the next succeeding
paragraph applies) to all holders of Common Stock in an aggregate amount that,
combined together with (i) other such all-cash distributions made within the
preceding 12 months in respect of which no adjustment has been made and (ii) any
cash and the fair market value of other consideration payable in respect of any
tender offer by the Company or any of its subsidiaries for Common Stock
concluded within the preceding 12 months in respect of which no adjustment has
been made, exceeds 12.5% of the Company's market capitalization (being the
product of the Current Market Price per share of the Common Stock on the record
date for such distribution times the number of shares of Common Stock
outstanding) on such date, and (f) the successful completion of a tender offer
made by the Company or any of its subsidiaries for Common Stock which involves
an aggregate consideration that, together with (i) any cash and other
consideration payable in a tender offer by the Company or any of its
subsidiaries for Common Stock expiring within the 12 months preceding the
expiration of such tender offer in respect of which no adjustment has been made
and (ii) the aggregate amount of any such all-cash distributions referred to in
(e) above to all holders of Common Stock within the 12 months preceding the
expiration of such tender offer in respect of which no adjustments have been
made, exceeds 10% of the Company's market capitalization on the expiration of
such tender offer. The Company reserves the right to make such reductions in the
Conversion Rate in addition to those required in the foregoing provisions as it
considers to be advisable in order that any event treated for United States
federal income tax purposes as a dividend of stock or stock rights will not be
taxable to the recipients. No adjustment of the Conversion Rate will be required
to be made until the cumulative adjustments amount to 1.0% or more of the
Conversion Rate. (sec. 12.4) The Company shall compute any adjustments to the
Conversion Rate pursuant to this paragraph and will give notices of any
adjustments by mail to Holders of Notes. (sec. 12.5)
 
     In case of any consolidation or merger of the Company with or into another
Person or any merger of another Person into the Company (other than a merger
which does not result in any reclassification, conversion, exchange or
cancellation of the Common Stock), or in case of any sale or transfer of all or
substantially all of the assets of the Company, each Note then outstanding will,
without the consent of the Holder of any Note, become convertible only into the
kind and amount of securities, cash and other property receivable upon such
consolidation, merger, sale or transfer by a holder of the number of shares of
Common Stock into which such Note was convertible immediately prior thereto
(assuming such holder of Common Stock failed to exercise any rights of election
and that such Note was then convertible). (sec. 12.11)
 
                                       20
<PAGE>   22
 
     If at any time the Company makes a distribution of property to its
stockholders which would be taxable to such stockholders as a dividend for
United States federal income tax purposes (e.g., distributions of evidences of
indebtedness or assets of the Company, but generally not stock dividends on
common stock or rights to subscribe for common stock) and, pursuant to the
anti-dilution provisions of the Indenture, the number of shares into which Notes
are convertible is increased, such increase may be deemed for federal income tax
purposes to be the payment of a taxable dividend to Holders of Notes. See
"Certain Federal Income Tax Considerations -- Dividends".
 
SUBORDINATION
 
   
     The payment of the principal of, premium, if any, and interest on the Notes
(including any Additional Amounts and any amounts payable upon the redemption or
the repurchase of the Notes permitted by the Indenture) will be subordinated in
right of payment to the extent set forth in the Indenture to the prior payment
in full of the principal of, premium, if any, interest and other amounts in
respect of all Senior Indebtedness of the Company. The principal amount of
outstanding Senior Indebtedness was approximately $30,471,000 at December 31,
1996. Senior Indebtedness is defined in the Indenture to mean the principal of
(and premium, if any) and interest (including all interest accruing subsequent
to the commencement of any bankruptcy or similar proceeding, whether or not a
claim for post-petition interest is allowable as a claim in any such proceeding)
on, and all fees and other amounts payable in connection with, the following,
whether absolute or contingent, secured or unsecured, due or to become due,
outstanding on the date of the Indenture or thereafter created, incurred or
assumed: (a) indebtedness of the Company to banks, insurance companies and other
financial institutions evidenced by credit or loan agreements, notes or other
written obligations, (b) all other indebtedness of the Company (including
indebtedness of others guaranteed by the Company) other than the Notes, whether
outstanding on the date of the Indenture or thereafter created, incurred or
assumed, which is (i) for money borrowed or (ii) evidenced by a note or similar
instrument given in connection with the acquisition of any businesses,
properties or assets of any kind, (c) obligations of the Company as lessee under
leases required to be capitalized on the balance sheet of the lessee under
generally accepted accounting principles, (d) obligations of the Company under
interest rate and currency swaps, caps, floors, collars or similar agreements or
arrangements intended to protect the Company against fluctuations in interest or
currency exchange rates and (e) renewals, extensions, modifications,
restatements and refundings of, or any indebtedness or obligation issued in
exchange for, any such indebtedness or obligation described in clauses (a)
through (e) of this paragraph; provided, however, that Senior Indebtedness shall
not include any such indebtedness or obligation (a) if the terms of such
indebtedness or obligation (or the terms of the instrument under which, or
pursuant to which, it is issued) provides that such indebtedness or obligation
is not superior in right of payment to the Notes, (b) if such indebtedness or
obligation is non-recourse to the Company or (c) any conditional sale contract
or any account payable or any other indebtedness created or assumed by the
Company in the ordinary course of business in connection with the obtaining of
materials, inventories or services. (sec.sec. 1.1, 13.1 and 13.2)
    
 
     No payment on account of principal of, premium, if any, or interest on the
Notes (including any Additional Amounts and any amounts payable upon the
redemption or the repurchase of the Notes permitted by the Indenture) may be
made by the Company if there is a default in the payment of principal, premium,
if any, or interest (including a default under any repurchase or redemption
obligation) with respect to any Senior Indebtedness or if any other event of
default with respect to any Senior Indebtedness, permitting the holders thereof
to accelerate the maturity thereof, shall have occurred and shall not have been
cured or waived or shall not have ceased to exist after written notice to the
Company and the Trustee by any holder of Senior Indebtedness. Upon any
acceleration of the principal due on the Notes or payment or distribution of
assets of the Company to creditors upon any dissolution, winding up, liquidation
or reorganization, whether voluntary or involuntary, marshalling of assets,
assignment for the benefit of creditors, or in bankruptcy, insolvency,
receivership or other similar proceedings of the Company, all principal,
premium, if any, and interest or other amounts due on all Senior Indebtedness
must be paid in full before the Holders of the Notes are entitled to receive any
payment. By reason of such subordination, in the event of insolvency, creditors
of the Company who are holders of Senior
 
                                       21
<PAGE>   23
 
Indebtedness are likely to recover more, ratably, than the Holders of the Notes,
and such subordination may result in a reduction or elimination of payments to
the Holders of the Notes. (sec. 13.2)
 
   
     In addition, the Notes will be structurally subordinated to all
indebtedness and other liabilities (including trade payables and lease
obligations) of the Company's subsidiaries, as any right of the Company to
receive any assets of its subsidiaries upon their liquidation or reorganization
(and the consequent right of the Holders of the Notes to participate in those
assets) will be effectively subordinated to the claims of that subsidiary's
creditors (including trade creditors), except to the extent that the Company
itself is recognized as a creditor of such subsidiary, in which case the claims
of the Company would still be subordinate to any security interest in the assets
of such subsidiary and any indebtedness of such subsidiary senior to that held
by the Company. As of December 31, 1996, there was outstanding approximately
$29,205,000 of indebtedness of subsidiaries of the Company (excluding
intercompany indebtedness); this amount has been included in the principal
amount of the Company's outstanding Senior Indebtedness at December 31, 1996, as
set forth above.
    
 
     The Indenture does not limit the Company's or its subsidiaries' ability to
incur Senior Indebtedness or any other indebtedness.
 
REDEMPTION
 
  Optional Redemption
 
     Subject to the discussion under " -- Redemption for Taxation Reasons"
below, the Notes may not be redeemed prior to the close of business on May 31,
1999. Thereafter, the Notes may be redeemed, in whole or in part, at the option
of the Company, at the redemption price specified below, upon not less than 30
nor more than 60 days' prior notice as provided under " -- Notices" below.
 
     The redemption price (expressed as a percentage of principal amount) for
the 12-month period beginning as of the close of business on May 31, 1999 is
101.0625% together with accrued interest to the date of redemption.
(sec.sec. 2.2, 11.1, 11.5, 11.7)
 
     No sinking fund is provided for the Notes.
 
  Redemption for Taxation Reasons
 
     If the Company has or will become obligated to pay Additional Amounts (as
described below under " -- Payment of Additional Amounts") as a result of any
change in, or amendment to, the laws (including any regulations or rulings
promulgated thereunder) of the United States or any political subdivision or
taxing authority thereof or therein affecting taxation, or any change in, or
amendment to, the application or official interpretation of such laws,
regulations or rulings (any such change or amendment being herein referred to as
a "Tax Law Change"), and such obligation cannot be avoided by the Company taking
reasonable measures available to it, the Tax Affected Notes (as hereinafter
defined) may be redeemed, at the option of the Company, in whole but not in
part. With respect to any Tax Law Change, "Tax Affected Notes" shall include any
Note that, on or before the 30th day after the date on which the Company
publishes a notice of redemption pursuant to this paragraph, is delivered to the
Trustee together with a written statement from or on behalf of the beneficial
owner of such Note to the effect that such beneficial owner has or will become
entitled to receive Additional Amounts as a result of such Tax Law Change. Such
redemption shall be upon not less than 30 nor more than 60 days' prior notice as
provided under " -- Notices" below, at a redemption price equal to 100% of the
principal amount of the Notes, plus accrued interest to the redemption date and
any Additional Amounts then payable; provided, however, that (1) no such notice
of redemption shall be given earlier than 90 days prior to the earliest date on
which the Company would be obligated to pay any such Additional Amounts were a
payment in respect of the Notes then due and (2) at the time such notice of
redemption is given, the obligation to pay such Additional Amounts remains in
effect. Prior to the publication of any notice of redemption pursuant to this
paragraph, the Company shall deliver to the Trustee (a) a certificate stating
that the Company is entitled to effect such redemption and setting forth a
statement of facts showing that
 
                                       22
<PAGE>   24
 
the conditions precedent to the right of the Company so to redeem have occurred
and (b) an opinion of independent counsel of recognized standing, to the effect
that the Company has or will become obligated to pay such Additional Amounts as
a result of a Tax Law Change.
 
PAYMENT AND CONVERSION
 
     The principal of Notes will be payable in U.S. dollars, against surrender
thereof at the Corporate Trust Office of the Trustee in the Borough of
Manhattan, The City of New York, or, subject to any applicable laws and
regulations, at the office of any Paying Agent, by dollar check drawn on, or by
transfer to a dollar account (such transfer to be made only to Holders of an
aggregate principal amount of Notes in excess of $2,000,000) maintained by the
Holder with a bank in New York City. Payment of any installment of interest on
Notes will be made to the Person in whose name such Notes (or any predecessor
Note) is registered at the close of business on the May 15 or the November 15
(whether or not a Business Day) immediately preceding the relevant Interest
Payment Date (a "Regular Record Date"). Payments of such interest will be made
by a dollar check drawn on a bank in New York City mailed to the Holder at such
Holder's registered address or, upon application by the Holder thereof to the
Trustee not later than the applicable Regular Record Date, by transfer to a
dollar account (such transfer to be made only to Holders of an aggregate
principal amount of Notes in excess of $2,000,000) maintained by the Holder with
a bank in New York City. No transfer to a dollar account will be made unless the
Trustee has received written wire instructions not less than 15 days prior to
the relevant payment date. (sec. 2.2)
 
     Payments in respect of the principal of (and premium, if any) and interest
on any Global Note registered in the name of DTC or its nominee will be payable
by the Trustee to DTC or its nominee in its capacity as the registered holder
under the Indenture. Under the terms of the Indenture, the Company and the
Trustee will treat the persons in whose names the Notes, including the Global
Notes, are registered as the owners thereof for the purpose of receiving such
payments and for any and all other purposes whatsoever. Consequently, neither
the Company, the Trustee nor any agent of the Company or the Trustee has or will
have any responsibility or liability for (i) any aspect of DTC's records or any
Participant's or Indirect Participant's records relating to or payments made on
account of beneficial ownership interests in the Global Notes, or for
maintaining, supervising or reviewing any of DTC's records or any Participant's
or Indirect Participant's records relating to the beneficial ownership interests
in the Global Notes, or (ii) any other matter relating to the actions and
practices of DTC or any of its Participants or Indirect Participants.
 
     Any payment on the Notes due on any day which is not a Business Day need
not be made on such day, but may be made on the next succeeding Business Day
with the same force and effect as if made on such due date, and no interest
shall accrue on such payment for the period from and after such date. "Business
Day", when used with respect to any place of payment, place of conversion or any
other place, as the case may be, means each Monday, Tuesday, Wednesday, Thursday
and Friday which is not a day on which banking institutions in such place of
payment, place of conversion or other place, as the case may be, are authorized
or obligated by law or executive order to close; provided, however, that a day
on which banking institutions in New York, New York or London, England are
authorized or obligated by law or executive order to close shall not be a
Business Day for certain purposes. (sec.sec. 1.1 and 2.2)
 
     Notes may be surrendered for conversion at the Corporate Trust Office of
the Trustee in the Borough of Manhattan, The City of New York. Notes surrendered
for conversion must be accompanied by appropriate notices, and any payments in
respect of interest or taxes, as applicable, as described above under
"-- Conversion Rights". (sec.sec. 2.2 and 12.2)
 
     The Company may at any time terminate the appointment of any Paying Agent
or Conversion Agent and appoint additional or other Paying Agents and Conversion
Agents, provided that until the Notes have been delivered to the Trustee for
cancellation, or moneys sufficient to pay the principal of, premium, if any, and
interest on the Notes have been made available for payment and either paid or
returned to the Company as provided in the Indenture, it will maintain an office
or agency in the Borough of Manhattan, The City of New York for surrender of
Notes for conversion, and in a Western European city for payments
 
                                       23
<PAGE>   25
 
with respect to the Notes and for the surrender of Notes for conversion. Notice
of any such termination or appointment and of any change in the office through
which any Paying Agent or Conversion Agent will act will be given in accordance
with "-- Notices" below. (sec. 10.2)
 
     Interest payable on Notes on any redemption date or repurchase date that is
an Interest Payment Date will be paid to the Holders of record as of the
immediately preceding Regular Record Date. (sec.sec. 11.7, 14.1 and 14.2)
 
     All moneys deposited with the Trustee or any Paying Agent, or then held by
the Company, in trust for the payment of principal of, premium, if any, or
interest on any Notes which remain unclaimed at the end of two years after such
payment has become due and payable will be repaid to the Company, and the Holder
of such Note will thereafter look only to the Company for payment thereof.
(sec. 10.3)
 
PAYMENT OF ADDITIONAL AMOUNTS
 
     The Company will pay to the Holder of any Note who is a United States Alien
such additional amounts ("Additional Amounts") as may be necessary in order that
every net payment of the principal of, premium, if any, and interest on such
Note (including any payment of the Repurchase Price in respect of such Note),
after deduction or withholding for or on account of any present or future tax,
assessment or governmental charge imposed upon or as a result of such payment by
the United States or any political subdivision or taxing authority thereof or
therein, will not be less than the amount provided for in such Note to be then
due and payable; provided, however, that the foregoing obligation to pay
Additional Amounts will not apply to:
 
          (a) any tax, assessment or other governmental charge which would not
     have been so imposed but for (i) the existence of any present or former
     connection between such Holder (or between a fiduciary, settlor,
     beneficiary, member, shareholder of or possessor of a power over such
     Holder, if such Holder is an estate, a trust, a partnership or a
     corporation) and the United States or any political subdivision or taxing
     authority thereof or therein, including, without limitation, such Holder
     (or such fiduciary, settlor, beneficiary, member, shareholder or possessor)
     being or having been a citizen or resident of the United States or treated
     as a resident thereof, or being or having been engaged in trade or business
     or present therein, or having or having had a permanent establishment
     therein, or (ii) such Holder's present or former status as a personal
     holding company, a foreign personal holding company with respect to the
     United States, or a foreign private foundation or foreign tax exempt entity
     for United States tax purposes, or a corporation which accumulates earnings
     to avoid United States federal income tax;
 
          (b) any tax, assessment or other governmental charge which would not
     have been so imposed but for the presentation by the Holder of such Note
     for payment on a date more than 15 days after the date on which such
     payment became due and payable or the date on which payment thereof is duly
     provided for, whichever occurs later;
 
          (c) any estate, inheritance, gift, sales, transfer, personal property
     or similar tax, assessment or governmental charge;
 
          (d) any tax, assessment or other governmental charge which would not
     have been imposed but for the failure to comply with any certification,
     identification or other reporting requirements concerning the nationality,
     residence, identity or connection with the United States of the Holder or
     beneficial owner of such Note, if compliance is required by statute or by
     regulation of the United States as a precondition to relief or exemption
     from such tax, assessment or other governmental charge;
 
          (e) any tax, assessment or other governmental charge which is payable
     otherwise than by deduction or withholding from payments of principal of,
     premium, if any, or interest on such Note;
 
          (f) any tax, assessment or other governmental charge imposed on a
     holder that actually or constructively owns 10% or more of the total
     combined voting power of all classes of stock of the
 
                                       24
<PAGE>   26
 
     Company entitled to vote or that is a controlled foreign corporation
     related to the Company through stock ownership;
 
          (g) any tax, assessment or other governmental charge required to be
     withheld by any Paying Agent from any payment of the principal of, premium,
     if any, or interest on any Note, if such payment can be made without such
     withholding by any other Paying Agent in Western Europe;
 
          (h) any tax, assessment or other governmental charge imposed on a
     Holder that is a partnership or a fiduciary or other than the sole
     beneficial owner of such payment, but only to the extent that any
     beneficial owner or member of the partnership or beneficiary or settlor
     with respect to the fiduciary would not have been entitled to the payment
     of Additional Amounts had the beneficial owner, member, beneficiary or
     settlor directly been the Holder of the Note; or
 
          (i) any combination of items (a), (b), (c), (d), (e), (f), (g) and
     (h). (sec. 2.2)
 
Notwithstanding the foregoing, the Company shall not be obligated to pay
Additional Amounts in respect of payments becoming due on the Notes more than 15
days after the redemption date for a redemption described in the first paragraph
under "-- Redemption -- Redemption for Taxation Reasons", except to the extent
that the Company's obligation to pay such Additional Amounts does not arise from
the Tax Law Change that resulted in such redemption.
 
     For purposes of this Prospectus, "United States" means the United States of
America (including the States and the District of Columbia), its territories,
its possessions and other areas subject to its jurisdiction and a "United States
Alien" is any person who, for United States federal income tax purposes, is a
foreign corporation, a nonresident alien individual, a nonresident alien
fiduciary of a foreign estate or trust, or a foreign partnership one or more of
the members of which is for United States federal income tax purposes, a foreign
corporation, a nonresident alien individual or a nonresident alien fiduciary of
a foreign estate or trust. (sec. 2.2)
 
REPURCHASE AT OPTION OF HOLDERS UPON A CHANGE IN CONTROL
 
     If a Change in Control (as defined) occurs, each Holder of Notes shall have
the right, at the Holder's option, to require the Company to repurchase all of
such Holder's Notes, or any portion of a Note, that is $5,000 or an integral
multiple of $1,000 in excess thereof, on the date (the "Repurchase Date") that
is 45 days after the date of the Company Notice (as defined), at a price equal
to 100% of the principal amount of the Notes to be repurchased together with
interest accrued to the Repurchase Date (the "Repurchase Price"). (sec. 14.1)
 
     The Company may, at its option, in lieu of paying the Repurchase Price in
cash, pay the Repurchase Price in Common Stock valued at 95% of the average of
the closing prices of the Common Stock for the five trading days ending on and
including the third trading day preceding the Repurchase Date; provided that
payment may not be made in Common Stock unless the Company satisfies certain
conditions with respect to such payment as provided in the Indenture.
(sec.sec. 14.1 and 14.2)
 
     Within 30 days after the occurrence of a Change in Control, the Company is
obligated to give to all Holders of the Notes notice, as provided in the
Indenture (the "Company Notice"), of the occurrence of such Change in Control
and of the repurchase right arising as a result thereof, or, at the request of
the Company on or before the 15th day after such occurrence, the Trustee shall
give the Company Notice. The Company must also deliver a copy of the Company
Notice to the Trustee and to the office of each Paying Agent. To exercise the
repurchase right, a Holder of Notes must deliver on or before the 30th day after
the date of the Company Notice irrevocable written notice to the Trustee or any
Paying Agent of the Holder's exercise of such right, together with the Notes
with respect to which the right is being exercised. (sec. 14.3)
 
                                       25
<PAGE>   27
 
     A Change in Control shall be deemed to have occurred at such time after the
original issuance of the Notes as there shall occur:
 
          (i) the acquisition by any Person (including any syndicate or group
     deemed to be a "person" under Section 13(d)(3) of the Exchange Act) of
     beneficial ownership, directly or indirectly, through a purchase, merger or
     other acquisition transaction or series of transactions, of shares of
     capital stock of the Company entitling such Person to exercise 50% or more
     of the total voting power of all shares of capital stock of the Company
     entitled to vote generally in elections of directors, other than any such
     acquisition by the Company, any subsidiary of the Company or any employee
     benefit plan of the Company; or
 
          (ii) any consolidation or merger of the Company with or into, any
     other Person, any merger of another Person into the Company, or any
     conveyance, sale, transfer or lease of all or substantially all of the
     assets of the Company to another Person (other than (a) any such
     transaction (x) which does not result in any reclassification, conversion,
     exchange or cancellation of outstanding shares of Common Stock and (y)
     pursuant to which holders of Common Stock immediately prior to such
     transaction have the entitlement to exercise, directly or indirectly, 50%
     or more of the total voting power of all shares of capital stock entitled
     to vote generally in the election of directors of the continuing or
     surviving person immediately after such transaction and (b) any merger
     which is effected solely to change the jurisdiction of incorporation of the
     Company and results in a reclassification, conversion or exchange of
     outstanding shares of Common Stock into solely shares of common stock);
 
provided, however, that a Change in Control shall not be deemed to have occurred
if the closing price per share of the Common Stock for any five trading days
within the period of 10 consecutive trading days ending immediately after the
later of the Change in Control or the public announcement of the Change in
Control (in the case of a Change in Control under clause (i) above) or ending
immediately before the Change in Control (in the case of a Change in Control
under clause (ii) above) shall equal or exceed 105% of the Conversion Price of
the Notes in effect on each such trading day. The "Conversion Price" is equal to
$1,000 divided by the Conversion Rate. "Beneficial Owner" shall be determined in
accordance with Rule 13d-3 promulgated by the Commission under the Exchange Act,
as in effect on the date of execution of the Indenture. (sec. 14.4)
 
     The Company may, to the extent permitted by applicable law, at any time
purchase Notes in the open market or by tender at any price or by private
agreement. Any Note so purchased by the Company may, to the extent permitted by
applicable law and subject to restrictions contained in the Underwriting
Agreement entered by and among the Company and the Initial Purchasers in
connection with the Original Offering, be re-issued or resold or may, at the
Company's option, be surrendered to the Trustee for cancellation. Any Notes
surrendered as aforesaid may not be re-issued or resold and will be cancelled
promptly.
 
     The foregoing provisions would not necessarily afford Holders of the Notes
protection in the event of highly leveraged or other transactions involving the
Company that may adversely affect Holders.
 
MERGERS AND SALES OF ASSETS BY THE COMPANY
 
     The Company shall not consolidate or merge with or into any other Person or
convey, transfer, sell or lease its properties and assets substantially as an
entirety to any Person, and the Company shall not permit any Person to
consolidate or merge with or into the Company or convey, transfer, sell or lease
such Person's properties and assets substantially as an entirety to the Company
unless (a) the Person formed by such consolidation or into or with which the
Company is merged or the Person to which the properties and assets of the
Company are so conveyed, transferred, sold or leased shall be a corporation,
limited liability company, partnership or trust organized and existing under the
laws of the United States, any State thereof or the District of Columbia and
shall expressly assume the payment of the principal of, premium, if any, and
interest on the Notes and the performance of the other covenants of the Company
under the Indenture, and (b) immediately after giving effect to such
transaction, no Event of Default, and
 
                                       26
<PAGE>   28
 
no event that, after notice or lapse of time or both, would become an Event of
Default, shall have occurred and be continuing. (sec. 7.1)
 
EVENTS OF DEFAULT
 
     The following will be Events of Default under the Indenture: (a) failure to
pay principal of or premium, if any, on any Note when due, whether or not such
payment is prohibited by the subordination provisions of the Notes and the
Indenture; (b) failure to pay any interest (including any Additional Amount) on
any Note or coupon when due, continuing for 30 days; (c) failure to provide a
Company Notice; (d) failure to perform any other covenant of the Company in the
Indenture, continuing for 60 days after written notice as provided in the
Indenture; (e) default in respect of any indebtedness for money borrowed by the
Company that results in acceleration of the maturity of an amount in excess of
$10,000,000 of indebtedness if such indebtedness is not discharged, or such
acceleration is not annulled, within 30 days after written notice as provided in
the Indenture; and (f) certain events of bankruptcy, insolvency or
reorganization. (sec. 5.1) Subject to the provisions of the Indenture relating
to the duties of the Trustee in case an Event of Default shall occur and be
continuing, the Trustee will be under no obligation to exercise any of its
rights or powers under the Indenture at the request or direction of any of the
Holders, unless such Holders shall have offered to the Trustee reasonable
indemnity. (sec. 6.3) Subject to such provisions for the indemnification of the
Trustee, the Holders of a majority in aggregate principal amount of the
Outstanding Notes will have the right to direct the time, method and place of
conducting any proceeding for any remedy available to the Trustee or exercising
any trust or power conferred on the Trustee. (sec. 5.12)
 
     If an Event of Default shall occur and be continuing, either the Trustee or
the Holders of at least 25% in principal amount of the Outstanding Notes may
accelerate the maturity of all Notes; provided, however, that after such
acceleration, but before a judgment or decree based on acceleration, the Holders
of a majority in aggregate principal amount of Outstanding Notes may, under
certain circumstances, rescind and annul such acceleration if all Events of
Default, other than the non-payment of principal of the Notes which have become
due solely by such declaration of acceleration, have been cured or waived as
provided in the Indenture. (sec. 5.2) For information as to waiver of defaults,
see "-- Meetings, Modification and Waiver".
 
     No Holder of any Note will have any right to institute any proceeding with
respect to the Indenture or for any remedy thereunder, unless such Holder shall
have previously given to the Trustee written notice of a continuing Event of
Default and the Holders of at least 25% in aggregate principal amount of the
Outstanding Notes shall have made written request, and offered reasonable
indemnity, to the Trustee to institute such proceeding as trustee, and the
Trustee shall not have received from the Holders of a majority in aggregate
principal amount of the Outstanding Notes a direction inconsistent with such
request and shall have failed to institute such proceeding within 60 days.
(sec. 5.7) However, such limitations do not apply to a suit instituted by a
Holder of a Note for the enforcement of payment of the principal of, premium, if
any, or interest on such Note on or after the respective due dates expressed in
such Note or of the right to convert such Note in accordance with the Indenture.
(sec. 5.8)
 
     The Company will be required to furnish to the Trustee annually a statement
as to the performance by the Company of certain of its obligations under the
Indenture and as to any default in such performance. (sec. 10.9)
 
MEETINGS, MODIFICATION AND WAIVER
 
     The Indenture contains provisions for convening meetings of the Holders of
Notes to consider matters affecting their interests. (Article Nine)
 
     Modifications and amendments of the Indenture may be made, and certain past
defaults by the Company may be waived, either (i) with the written consent of
the Holders of not less than a majority in aggregate principal amount of the
Notes at the time Outstanding or (ii) by the adoption of a resolution, at a
meeting of Holders of the Notes at which a quorum is present, by the Holders of
at least 66 2/3% in
 
                                       27
<PAGE>   29
 
aggregate principal amount of the Notes represented at such meeting. However, no
such modification or amendment may, without the consent of the Holder of each
Outstanding Note or coupon affected thereby, (a) change the Stated Maturity of
the principal of, or any installment of interest on, any Note or coupon, (b)
reduce the principal amount of, or the premium, if any, or interest on, any Note
or coupon, (c) reduce the amount payable upon a redemption or mandatory
repurchase, (d) modify the provisions with respect to the repurchase right of
the Holders in a manner adverse to the Holders, (e) change the obligation of the
Company to pay Additional Amounts pursuant to the Indenture in a manner adverse
to the Holders, (f) change the place or currency of payment of principal of,
premium, if any, or interest on, any Note (including any payment of the
Repurchase Price in respect of such Note) or coupon, (g) impair the right to
institute suit for the enforcement of any payment on or with respect to any Note
or coupon, (h) modify the obligation of the Company to maintain an office or
agency in New York City and in a Western European city, (i) except as otherwise
permitted or contemplated by provisions concerning consolidation, merger,
conveyance, transfer, sale or lease of all or substantially all of the property
and assets of the Company, adversely affect the right of Holders to convert any
of the Notes or to require the Company to repurchase any Note other than as
provided in the Indenture, (j) modify the subordination provisions in a manner
adverse to the Holders of the Notes, (k) reduce the above-stated percentage of
Outstanding Notes necessary to modify or amend the Indenture, (l) reduce the
percentage of aggregate principal amount of Outstanding Notes necessary for
waiver of compliance with certain provisions of the Indenture or for waiver of
certain defaults, (m) reduce the percentage in aggregate principal amount of
Outstanding Notes required for the adoption of a resolution or the quorum
required at any meeting of Holders of Notes at which a resolution is adopted, or
(n) modify the obligation of the Company to deliver information required under
Rule 144A to permit resales of Notes and Common Stock issuable upon conversion
thereof in the event the Company ceases to be subject to certain reporting
requirements under the United States securities laws (sec.sec. 8.2 and 5.13).
The quorum at any meeting called to adopt a resolution will be persons holding
or representing a majority in aggregate principal amount of the Notes at the
time Outstanding and, at any reconvened meeting adjourned for lack of a quorum,
25% of such aggregate principal amount. (sec. 9.4)
 
     The Holders of a majority in aggregate principal amount of the Outstanding
Notes may waive compliance by the Company with certain restrictive provisions of
the Indenture by written consent. (sec. 10.13) The Holders of a majority in
aggregate principal amount of the Outstanding Notes also may waive any past
default under the Indenture, except a default in the payment of principal,
premium, if any, or interest, by written consent. (sec. 5.13)
 
REGISTRATION RIGHTS
 
     The Selling Holders are entitled to the benefits of a registration rights
agreement dated as of May 17, 1996, between the Company and the Initial
Purchasers entered in connection with the Original Offering (the "Registration
Rights Agreement"). Pursuant to the Registration Rights Agreement, the Company
has, at its own expense, filed with the Commission a shelf registration
statement of which this Prospectus forms a part (the "Shelf Registration
Statement") covering resales by the holders of Notes in registered form (and the
shares of Common Stock issuable upon conversion of such Notes) which cannot be
resold in the United States except pursuant to a registration statement under
the Securities Act or an exemption from registration under the Securities Act
(collectively, the "Registrable Securities") and were not acquired in a
transaction in reliance on Regulation S. The Company will use reasonable efforts
to cause such Shelf Registration Statement to become effective as promptly as
practicable and keep such Shelf Registration Statement effective until such date
that is three years after the latest date of original issuance of the Notes or,
if earlier, until all of the Registrable Securities (i) have been sold in a
manner contemplated by the Shelf Registration Statement, (ii) have been
transferred in compliance with Rule 144 under the Securities Act or are
transferable pursuant to Rule 144(k) under the Securities Act, (iii) have been
sold in compliance with Regulation S (and do not constitute part of the unsold
allotment of a "distributor" within the meaning of Regulation S), or (iv) have
otherwise been transferred and a new security not subject to transfer
restrictions under the Securities Act has been delivered by or on behalf of the
Company. Notwithstanding the foregoing, the Company will be permitted, in
accordance with the
 
                                       28
<PAGE>   30
 
Registration Rights Agreement, to suspend the use of any Prospectus that is a
part of the Shelf Registration Statement during the existence of a state of
facts or the happening of an event (including without limitation pending
negotiations relating to, or the consummation of, a transaction or the
occurrence of any event which in the opinion of the Company might require
additional disclosure of material, non-public information by the Company in the
Shelf Registration Statement as to which the Company believes it has a bona fide
business purpose for preserving confidentiality or which renders the Company
unable to comply with the rules and regulations under the Securities Act) which
in the opinion of outside counsel to the Company might reasonably result in the
Shelf Registration Statement, or any amendment or post-effective amendment
thereto, or the Prospectus or any supplement thereto, or any document
incorporated therein by reference containing an untrue statement of material
fact or omitting to state a material fact.
 
     This summary of certain provisions of the Registration Rights Agreement
does not purport to be complete and is subject to, and qualified in its entirety
by reference to, all the provisions of the Registration Rights Agreement filed
as an exhibit to the Registration Statement, of which this Prospectus forms a
part.
 
TRANSFER, EXCHANGE AND WITHDRAWAL
 
     At the option of the Holder upon request confirmed in writing, and subject
to the terms of the Indenture, any Note in registered form will be exchangeable
at any time into an equal aggregate principal amount of Notes in registered form
of different authorized denominations. (sec. 3.5)
 
     Notes in registered form may be presented for registration of transfer
(with the form of transfer endorsed thereon duly executed) or exchange, at the
office of any transfer agent or at the office of the security registrar, without
service charge but, in the case of a transfer, upon payment of any taxes and
other governmental charges as described in the Indenture. Any registration of
transfer or exchange will be effected upon the transfer agent or the security
registrar, as the case may be, being satisfied with the documents of title and
identity of the person making the request, and subject to such reasonable
regulations as the Company may from time to time agree upon with the transfer
agents and the security registrar, all as described in the Indenture. Notes may
be transferred in whole or in part in authorized denominations. Upon surrender
for registration of transfer of any such Notes, one or more new Notes will be
deliverable, in accordance with the Indenture, at the office of any transfer
agent. (sec. 3.5)
 
     The Company has initially appointed the Trustee as security registrar and
transfer agent, acting through its Corporate Trust Offices in New York City. The
Company reserves the right to vary or terminate the appointment of the security
registrar or of any transfer agent or to appoint additional or other transfer
agents or to approve any change in the office through which any security
registrar or any transfer agent acts, provided that there will at all times be a
security registrar and a transfer agent in a Western European city.
(sec.sec. 3.5 and 10.2)
 
     In the event of a redemption of less than all of the Notes (other than, a
redemption for any of the reasons described under "-- Redemption -- Redemption
for Taxation Reasons") for any of the reasons set forth below under
"-- Redemption", the Company will not be required (a) to register the transfer
or exchange of Notes for a period of 15 days immediately preceding the date
notice is given identifying the serial numbers of the Notes called for such
redemption or (b) to register the transfer of or exchange any Note, or portion
thereof, called for redemption. (sec. 3.5)
 
     Exchange of Interests in the Restricted Global Note and Regulation D Notes
for Interests in Unrestricted Global Note.  Upon each sale by a Selling Holder
of Notes or Conversion Shares, as the case may be, offered hereby, such Selling
Holder will be required to deliver a Notice (the "Notice") of such sale to the
Trustee and the Company. The Notice will among other things, identify the sale
as a sale pursuant to the Registration Statement of which this Prospectus forms
a part, certify that the prospectus delivery requirements, if any, of the
Securities Act have been satisfied, and certify that the Selling Holder and the
aggregate principal amount of Notes or the number of Conversion Shares owned by
such holder are identified in the Prospectus in accordance with the applicable
rules and regulations under the
 
                                       29
<PAGE>   31
 
Securities Act. A copy of the Notice is attached hereto as Appendix A.
Additional copies are available upon request to Corporate Secretary, Quintiles
Transnational Corp., 4709 Creekstone Drive, Riverbirch Building, Suite 300,
Durham, North Carolina 27703-8411, telephone (919) 941-2000.
 
     Upon receipt by the Trustee of the Notice relating to a sale of Notes, an
appropriate adjustment will be made to reflect a decrease in the principal
amount of the Restricted Global Note or the cancellation of a Note in
certificated form upon the transfer thereof, and a corresponding increase in the
principal amount of the Unrestricted Global Note (or upon the request of a
Selling Holder of Notes in certificated form, the authentication and delivery of
a Note in certificated form).
 
     Any beneficial interest in the Restricted Global Note that is transferred
to a person who takes delivery in the form of an interest in the Unrestricted
Global Note will, upon transfer, cease to be an interest in the Restricted
Global Note and will become an interest in the Unrestricted Global Note and,
accordingly, will thereafter be subject to all procedures applicable to the
Unrestricted Global Note for so long as it remains such an interest.
 
     Exchange of Interests in Global Notes for Certificated Notes.  As long as
DTC, or its nominee, is the registered Holder of a Global Note, DTC or such
nominee, as the case may be, will be considered the sole owner and Holder of the
Notes represented by such Global Note for all purposes under the Indenture and
the Notes. Unless DTC notifies the Company that it is unwilling or unable to
continue as depository for a Global Note, or ceases to be a "Clearing Agency"
registered under the Exchange Act, or announces an intention permanently to
cease business or does in fact do so, or an Event of Default has occurred and is
continuing with respect to a Global Note, owners of beneficial interests in a
Global Note will not be entitled to have any portions of such Global Note
registered in their names, will not receive or be entitled to receive physical
delivery of Notes in definitive form and will not be considered the owners or
Holders of the Global Note (or any Notes represented thereby) under the
Indenture or the Notes. In addition, no beneficial owner of an interest in a
Global Note will be able to transfer that interest except in accordance with
DTC's applicable procedures (in addition to those under the Indenture referred
to herein). In the event that owners of beneficial interests in a Global Note
become entitled to receive Notes in certificated form, such Notes will be issued
only as Notes in certificated form in denominations of $1,000 and integral
multiples thereof.
 
     Transfers involving an exchange of a beneficial interest in the Restricted
Global Note for a beneficial interest in the Unrestricted Global Note or vice
versa will be effected in DTC by means of an instruction originated by the
Trustee through the DTC/Deposit Withdraw at Custodian (DWAC) System.
Accordingly, appropriate adjustments will be made to reflect a decrease in the
principal amount of the Restricted Global Note and a corresponding increase in
the principal amount of the Unrestricted Global Note or vice versa, as
applicable.
 
TITLE
 
     The Company, the Trustee, any Paying Agent and any Conversion Agent may
treat the registered owner (as reflected in the Security Register) of any Note
as the absolute owner thereof (whether or not such Note shall be overdue) for
the purpose of making payment and for all other purposes. (sec. 2.2)
 
NOTICES
 
     Notices to Holders of Notes will be given by mail to the addresses of such
Holders as they appear in the Security Register. Such notices will be deemed to
have been given on the date of such mailing. (sec.sec. 1.1 and 1.6)
 
     Notice of a redemption of Notes will be given at least once not less than
30 nor more than 60 days (and in the case of the redemption described in the
second paragraph under "-- Redemption -- Redemption for Taxation Reasons", at
least 75 days) prior to the redemption date (which notice shall be published in
accordance with the procedures described in the preceding paragraph, but shall
be
 
                                       30
<PAGE>   32
 
irrevocable except as otherwise provided in the second paragraph under
"-- Redemption -- Redemption for Taxation Reasons") and will specify the
redemption date.
 
REPLACEMENT OF NOTES
 
     Notes that become mutilated, destroyed, stolen or lost will be replaced by
the Company at the expense of the Holder upon delivery to the Trustee of the
mutilated Notes or evidence of the loss, theft or destruction thereof
satisfactory to the Company and the Trustee. In the case of a lost, stolen or
destroyed Note, indemnity satisfactory to the Trustee and the Company may be
required at the expense of the Holder of such Note before a replacement Note
will be issued. (sec. 3.6)
 
PAYMENT OF STAMP AND OTHER TAXES
 
     The Company will pay all stamp and other duties, if any, which may be
imposed by the United States or any political subdivision thereof or taxing
authority thereof or therein with respect to the issuance of the Notes. Except
as described under "--Payment of Additional Amounts", the Company will not be
required to make any payment with respect to any other tax, assessment or
governmental charge imposed by any government or any political subdivision
thereof or taxing authority thereof or therein.
 
DEPOSITORY PROCEDURES WITH RESPECT TO GLOBAL NOTES
 
     With respect to the Global Notes, DTC has advised the Company as follows:
DTC is a limited purpose trust company organized under the laws of the State of
New York, a member of the Federal Reserve System, a "clearing corporation"
within the meaning of the Uniform Commercial Code, as amended, and a "Clearing
Agency" registered pursuant to the provisions of Section 17A of the Exchange
Act. DTC was created to hold securities for its participating organizations
(collectively, the "Participants") and to facilitate the clearance and
settlement of transactions in those securities between Participants through
electronic book-entry changes in accounts of its Participants. The Participants
include securities brokers and dealers, banks, trust companies, clearing
corporations and certain other organizations. Access to DTC's system is also
available to other entities such as banks, brokers, dealers and trust companies
that clear through or maintain a custodial relationship with a Participant,
either directly or indirectly (collectively, the "Indirect Participants").
Persons who are not Participants may beneficially own securities held by or on
behalf of DTC only through the Participants or the Indirect Participants. The
ownership interest and transfer of ownership interest of each actual purchaser
of each security held by or on behalf of DTC are recorded on the records of the
Participants and Indirect Participants.
 
     DTC has also advised the Company that pursuant to procedures established by
it, (i) upon deposit of the Global Notes, DTC credits the accounts of designated
Participants with portions of the principal amount of the Global Notes and (ii)
ownership of such interests in the Global Notes will be shown on, and the
transfer of ownership thereof will be effected only through, records maintained
by DTC (with respect to the Participants) or by the Participants and the
Indirect Participants (with respect to other owners of beneficial interests in
the Global Notes).
 
     Investors in the Global Notes may hold their interests therein directly
through DTC, if they are Participants in such system, or indirectly through
organizations which are Participants in such system. All interests in a Global
Note may be subject to the procedures and requirements of DTC.
 
     The laws of some states require that certain persons take physical delivery
in definitive form of securities that they own. Consequently, the ability to
transfer beneficial interests in a Global Note to such persons may be limited to
that extent. Because DTC can act only on behalf of its Participants, which in
turn act on behalf of Indirect Participants and certain banks, the ability of a
person having beneficial interests in a Global Note to pledge such interests to
persons or entities that do not participate in the DTC system, or otherwise take
actions in respect of such interests, may be affected by the lack of a physical
certificate evidencing such interests.
 
                                       31
<PAGE>   33
 
     EXCEPT AS DESCRIBED ABOVE UNDER "-- FORM, DENOMINATION AND WITHDRAWAL",
OWNERS OF INTERESTS IN THE GLOBAL NOTES WILL NOT HAVE NOTES REGISTERED IN THEIR
NAMES, WILL NOT RECEIVE PHYSICAL DELIVERY OF NOTES IN CERTIFICATED FORM AND WILL
NOT BE CONSIDERED THE REGISTERED OWNERS OR HOLDERS THEREOF UNDER THE INDENTURE
FOR ANY PURPOSE.
 
     DTC has advised the Company that its current practice, upon receipt of any
payment in respect of interests in securities such as the Global Notes
(including principal and interest) held by it or its nominee, is to credit the
accounts of the relevant Participants with the payment on the payment date, in
amounts proportionate to their respective holdings in principal amount of
beneficial interests in the relevant security such as the Global Notes as shown
on the records of DTC unless DTC has reason to believe it will not receive
payment on such payment date. Payments by the Participants and the Indirect
Participants to the beneficial owners of Notes will be governed by standing
instructions and customary practices, as is now the case with securities held
for the accounts of customers registered in "street name". Such payments will be
the responsibility of the Participants or the Indirect Participants and will not
be the responsibility of DTC, the Trustee or the Company. Neither the Company
nor the Trustee will be liable for any delay by DTC or any of its Participants
or Indirect Participants in identifying the beneficial owners of the Notes, and
the Company and the Trustee may conclusively rely on and will be protected in
relying on instructions from DTC or its nominee as the registered owner of the
Global Notes for all purposes.
 
     Transfers of beneficial interests in the Global Notes between Participants
in DTC will be effected in accordance with DTC's procedures, and such beneficial
interests will trade in DTC's Same-Day Funds Settlement System; and
consequently, secondary market trading activity in such interests will settle in
immediately available funds.
 
     DTC has advised the Company that it will take any action permitted to be
taken by a Holder of Notes only at the direction of one or more Participants to
whose account with DTC interests in the Global Notes are credited and only in
respect of such portion of the aggregate principal amount of the Notes as to
which such Participant or Participants has or have given such direction.
However, if there is an Event of Default under the Notes, DTC reserves the right
to exchange the Global Notes for legended Notes in certificated form, and to
distribute such Notes to its Participants.
 
     Although DTC has agreed to the foregoing procedures in order to facilitate
transfers of beneficial ownership interests in the Global Notes among
Participants of DTC, it is under no obligation to perform or continue to perform
such procedures, and such procedures may be discontinued at any time. None of
the Company, the Trustee nor any of their respective agents will have any
responsibility for the performance by DTC, its Participants or Indirect
Participants of their respective obligations under the rules and procedures
governing their operations, including maintaining, supervising or reviewing the
records relating to, or payments made on account of, beneficial ownership
interests in Registered Global Notes.
 
GOVERNING LAW
 
     The Indenture and the Notes are governed by and construed in accordance
with the laws of the State of New York, United States of America. (sec. 1.11)
 
THE TRUSTEE
 
     In case an Event of Default shall occur (and shall not be cured), the
Trustee will be required to use the degree of care of a prudent person in the
conduct of his own affairs in the exercise of its powers. Subject to such
provisions, the Trustee will be under no obligation to exercise any of its
rights or powers under the Indenture at the request of any of the Holders of
Notes, unless they shall have offered to the Trustee reasonable security or
indemnity. (sec.sec. 6.1 and 6.3)
 
                                       32
<PAGE>   34
 
                   CERTAIN FEDERAL INCOME TAX CONSIDERATIONS
 
     The following is a summary of certain United States federal income tax
considerations relevant to purchasers of the Notes and the Conversion Shares,
but does not purport to be a complete analysis of all the potential tax
considerations relating thereto. This summary is based on laws, regulations,
rulings and decisions now in effect (or, in the case of certain United States
Treasury Regulations ("Treasury Regulations"), now in proposed form), all of
which are subject to change. This summary deals only with holders that will hold
Notes and Common Stock into which Notes may be converted as "capital assets"
(within the meaning of Section 1221 of the Internal Revenue Code of 1986, as
amended (the "Code")) and does not address tax considerations applicable to
investors that may be subject to special tax rules, such as banks, tax-exempt
organizations, insurance companies, dealers in securities or currencies, persons
that will hold Notes as a position in a hedging transaction, "straddle" or
"conversion transaction" for tax purposes, or non-United States persons.
INVESTORS CONSIDERING THE PURCHASE OF NOTES SHOULD CONSULT THEIR OWN TAX
ADVISORS WITH RESPECT TO THE APPLICATION OF THE UNITED STATES FEDERAL INCOME TAX
LAWS TO THEIR PARTICULAR SITUATIONS AS WELL AS ANY TAX CONSEQUENCES ARISING
UNDER THE LAWS OF ANY STATE, LOCAL OR FOREIGN TAXING JURISDICTION OR UNDER ANY
APPLICABLE TAX TREATY.
 
  Payment of Interest
 
     Interest on a Note generally will be includible in the income of a holder
as ordinary income at the time such interest is received or accrued, in
accordance with such holder's method of accounting for United States federal
income tax purposes.
 
  Sale, Exchange or Redemption of the Notes
 
     Upon the sale, exchange or redemption of a Note, a holder generally will
recognize capital gain or loss equal to the difference between (i) the amount of
cash proceeds and the fair market value of any property received on the sale,
exchange or redemption (except to the extent such amount is attributable to
accrued interest income, which is taxable as ordinary income) and (ii) such
holder's adjusted tax basis in the Note. A holder's adjusted tax basis in a Note
generally will equal the cost of the Note to such holder, less any principal
payments received by such holder. Such capital gain or loss will be long-term
capital gain or loss if the holder's holding period in the Note is more than one
year at the time of sale, exchange or redemption.
 
  Conversion of the Notes
 
     A holder generally will not recognize any income, gain or loss upon
conversion of a Note into Common Stock except with respect to cash received in
lieu of a fractional Share of Common Stock. Such holder's tax basis in the
Common Stock received on conversion of a Note will be the same as such holder's
adjusted tax basis in the Note at the time of conversion (reduced by any basis
allocable to a fractional share interest), and the holding period for the Common
Stock received on conversion will generally include the holding period of the
Note converted.
 
     Cash received in lieu of a fractional share of Common Stock upon conversion
will be treated as a payment in exchange for the fractional share of Common
Stock. Accordingly, the receipt of cash in lieu of a fractional share of Common
Stock generally will result in a capital gain or loss (measured by the
difference between the cash received for the fractional share and the holder's
adjusted tax basis in the fractional share).
 
  Dividends
 
     Dividends paid on the Common Stock generally will be includible in the
income of a holder as ordinary income to the extent of the Company's current or
accumulated earnings and profits.
 
                                       33
<PAGE>   35
 
     If at any time (i) the Company makes a distribution of cash or property to
its stockholders or purchases Common Stock and such distribution or purchase
would be taxable to such stockholders as a dividend for United States federal
income tax purposes (e.g., distributions of evidences of indebtedness or assets
of the Company, but generally not stock dividends or rights to subscribe for
Common Stock) and, pursuant to the antidilution provisions of the Indenture, the
conversion rate of the Notes is increased, or (ii) the conversion rate of the
Notes is increased at the discretion of the Company, such increase in conversion
rate may be deemed to be the payment of a taxable dividend to holders of Notes
(pursuant to Section 305 of the Code). Holders of Notes could therefore have
taxable income as a result of an event pursuant to which they received no cash
or property.
 
  Market Discount
 
     In general, if a holder purchases a Note after its original issuance at a
price which is less than the Note's stated redemption price at maturity by more
than a statutory de minimis amount, the Note will be treated as having market
discount equal to the difference between the purchase price and the stated
redemption price at maturity. Such market discount is treated as accruing
ratably (or, if the holder elects, on a constant interest rate basis) over the
period between the holder's purchase of the Note and the Note's maturity date.
The holder of a Note with market discount must generally include accrued market
discount in ordinary income when the Note is sold or otherwise disposed of. In
addition, the holder must treat any principal payments received on the Note as
ordinary income to the extent of accrued market discount not previously taken
into income. Alternatively, the holder may elect to accrue market discount on a
constant yield basis. Absent such an election, holders who have incurred or
continued indebtedness in connection with the acquisition or holding of a Note
with market discount may be required to defer the deduction of all or a portion
of the interest on such indebtedness until the Note is disposed of in a taxable
transaction.
 
  Bond Premium
 
     In general, if a holder purchases a Note at a price in excess of the Note's
stated redemption price at maturity, the Note will be treated as having bond
premium equal to such excess. Bond premium with respect to a Note does not,
however, include any amount attributable to the conversion feature of the Note.
In general, a holder may elect to amortize bond premium with respect to a Note
using a constant yield method over the Note's remaining life. The amount of bond
premium amortized by an electing holder during a year will generally reduce the
amount required to be included in income during the year with respect to
interest on the Note and will reduce the holder's adjusted tax basis in the
Note. An election to amortize bond premium will apply to all taxable bonds held
by the holder at the beginning of the first taxable year to which the election
applies or thereafter acquired by the holder, and is irrevocable without the
consent of the Internal Revenue Service.
 
  Information Reporting and Backup Withholding Tax
 
     In general, information reporting requirements will apply to payments of
principal, premium, if any, and of interest on a Note, payments of dividends on
Common Stock, payments of the proceeds of the sale of a Note and payments of the
proceeds of the sale of Common Stock to certain non-corporate holders, and a 31%
backup withholding tax may apply to such payments if the holder (i) fails to
furnish or certify his correct taxpayer identification number to the payor in
the manner required, (ii) is notified by the Internal Revenue Service (the
"IRS") that he has failed to report payments of interest and dividends properly,
or (iii) under certain circumstances, fails to certify that he has not been
notified by the IRS that he is subject to backup withholding for failure to
report interest and dividend payments. Any amounts withheld under the backup
withholding rules from a payment to a holder will be allowed as a credit against
such holder's United States federal income tax and may entitle the holder to a
refund, provided that the required information is furnished to the IRS.
 
                                       34
<PAGE>   36
 
                          DESCRIPTION OF CAPITAL STOCK
 
COMMON STOCK
 
   
     The Company has authorized 200 million shares of Common Stock, $.01 par
value per share. As of December 31, 1996, 33,149,962 shares of Common Stock were
issued and outstanding and beneficially held by approximately 8,950
shareholders. Holders of Common Stock are entitled to one vote for each share
held on matters which are submitted to a vote of shareholders and are not
entitled to cumulative voting in the election of directors. Subject to any
preferential rights of holders of Preferred Stock, holders of Common Stock are
entitled to receive dividends, if any, as declared from time to time by the
Board of Directors out of assets legally available for such purpose. The Company
has never paid any cash dividends on Common Stock, and its existing domestic
credit facility prohibits the payment of dividends without the prior consent of
the lender. The Company does not anticipate paying any cash dividends in the
foreseeable future and intends to retain future earnings for the development and
expansion of its business. On liquidation, holders of Common Stock are entitled
to a pro rata portion of all assets available for distribution after payment of
creditors and the liquidation preference of any outstanding shares of Preferred
Stock. Holders of Common Stock have no preemptive rights or other rights to
subscribe for additional shares. All outstanding shares of Common Stock are, and
the Conversion Shares will be, upon issuance in accordance with the provisions
of the Indenture, duly authorized validly issued, fully paid and non-assessable.
Notices to Holders of Common Stock will be given by the Company by mail to the
addresses of such Holders as they appear in the books and records of the
Company.
    
 
PREFERRED STOCK
 
     The Company has authorized 25 million shares of Preferred Stock, $.01 par
value per share. The Company may issue shares of Preferred Stock in one or more
series as may be determined by the Company's Board of Directors, who may
establish, from time to time, the number of shares to be included in each
series, may fix the designation, powers, preferences and rights of the shares of
each such series and any qualifications, limitations or restrictions thereof,
and may increase or decrease the number of shares of any such series without any
further vote or action by the shareholders. Any Preferred Stock so issued by the
Board of Directors may rank senior to the Common Stock with respect to the
payment of dividends or upon liquidation, dissolution or winding up of the
Company, or both. In addition, any such shares of Preferred Stock may have class
or series voting rights. Under certain circumstances the issuance of Preferred
Stock or the existence of the unissued Preferred Stock may tend to discourage or
render more difficult a merger or other change in control of the Company. No
shares of Preferred Stock currently are outstanding, and the Company has no
current plans to issue Preferred Stock.
 
CERTAIN ARTICLES OF INCORPORATION AND BYLAWS PROVISIONS HAVING POTENTIAL
ANTI-TAKEOVER EFFECTS
 
  General
 
     A number of provisions of the Company's Articles of Incorporation and
Bylaws address matters of corporate governance and the rights of shareholders.
The following summary of such provisions is not intended to be complete and is
qualified in all respects by the Company's Articles of Incorporation and Bylaws.
Certain of these provisions, as well as the ability of the Board of Directors to
issue shares of Preferred Stock and to set the voting rights, preferences and
other terms thereof, may delay or prevent takeover attempts not first approved
by the Board of Directors (including takeovers which certain shareholders may
deem to be in their best interests). These provisions also could delay or
frustrate the removal of incumbent directors or the assumption of control by
shareholders.
 
  Classification of Board of Directors
 
     The Articles of Incorporation provide that the Board of Directors of the
Company is divided into three classes as nearly equal in number as possible. The
directors of each class elected after the expiration of the initial term of
office for such class will serve a term of three years. As a result of the
classification of
 
                                       35
<PAGE>   37
 
the Board of Directors, approximately one-third of the members of the Board of
Directors will be elected each year, and, two annual meetings will be required
for the Company's shareholders to change a majority of the members constituting
the Board of Directors.
 
  Nomination and Removal of Directors; Filling Vacancies
 
     The Company's Bylaws provide that nominations to the Board of Directors may
only be made by the Board of Directors, a nominating committee of the Board or
by any shareholder entitled to vote in elections of directors who complies with
certain notice procedures. In addition, the Articles of Incorporation provide
that (i) a director may be removed by the shareholders only upon the affirmative
vote of the holders of two-thirds of the voting power of all shares of capital
stock entitled to vote generally in the election of directors, however if a
Director was elected by the holders of one class or series of capital stock, or
a group of such class or series, only members of that voting group may
participate in the vote to remove him, and (ii) vacancies on the Board of
Directors may be filled only by the Board of Directors. The purpose of this
provision is to prevent a majority shareholder from circumventing the classified
board system by removing directors and filling the vacancies with new
individuals selected by that shareholder. Accordingly, the provision may have
the effect of impeding efforts to gain control of the Board by anyone who
obtains a controlling interest in the Company's Common Stock.
 
  Amendment of Articles of Incorporation
 
     The Articles of Incorporation of the Company provide that amendments to the
Articles of Incorporation may be adopted only upon the affirmative vote of the
holders of at least two-thirds of the voting power of all shares of capital
stock of the Company entitled to vote thereon. However, if such amendment has
received the prior approval by an affirmative vote of a majority of
Disinterested Directors, as defined below, then the affirmative vote of the
holders of at least a majority of the voting power of all shares of capital
stock of the Company entitled to vote thereon, or such greater percentage
approval as required by North Carolina law, is sufficient to adopt such
amendment. A Disinterested Director is defined as any member of the Board of
Directors who is unaffiliated with, and not a nominee of, a Control Person, as
defined below, and was a member of the Board of Directors prior to the time a
Control Person became such, and any successor of a Disinterested Director who is
unaffiliated with, and not a nominee of, a Control Person, who is recommended to
succeed a Disinterested Director by a majority of Disinterested Directors then
on the Board of Directors. A Control Person is defined as any corporation,
person, group, or other entity, which together with its affiliates, prior to a
Business Combination, as defined below, beneficially owns 10% or more of the
shares of any class of equity or convertible securities of the Company, and any
affiliate of any such corporation, person, group, or other entity; provided,
however, any corporation, person, group or other entity which, together with its
affiliates, prior to January 1, 1994 beneficially owned 10% or more of the
shares of any class of equity or convertible securities of the Company, and any
affiliate of any such party is not considered to be a Control Person.
 
  Amendment of Bylaws
 
     Subject to certain restrictions described below, either the Board of
Directors or the shareholders of the Company may amend the Company's Bylaws. The
Board of Directors may amend the Bylaws and adopt new Bylaws except that: (i) a
bylaw adopted, amended, or repealed by the shareholders may not be readopted,
amended, or repealed by the Board of Directors if neither the Articles of
Incorporation or a bylaw adopted by the shareholders authorizes the Board of
Directors to adopt, amend, or repeal that particular bylaw or the Bylaws
generally; (ii) a bylaw that fixes a greater quorum or voting requirement for
the Board of Directors may not be adopted by the Board of Directors by a vote of
less than a majority of the directors then in office and may not itself be
amended by a quorum or vote of directors less than the quorum or vote therein
prescribed or prescribed by a bylaw adopted or amended by the shareholders; and
(iii) if a bylaw fixing a greater quorum or voting requirement for the Board of
Directors is originally adopted by the shareholders, it may be amended or
repealed only by the shareholders, unless the Bylaws permit amendment or repeal
by the Board of Directors. The shareholders of the Company generally may
 
                                       36
<PAGE>   38
 
adopt, amend, or repeal the Bylaws upon the affirmative vote of the holders of
two-thirds of the voting power of all shares of capital stock entitled to vote
thereon.
 
  Supermajority Vote Requirement
 
     The Articles of Incorporation of the Company provide that, unless otherwise
more restrictively required by applicable law, any Business Combination, as
defined below, must be approved by a majority of a quorum of the Board of
Directors and must receive the level of shareholder approval, if any, as
follows: (i) to the extent shareholder approval is otherwise required by law, by
an affirmative vote of the shareholders holding at least a majority of the
shares of capital stock of the Company entitled to vote thereon, provided that
such Business Combination has been approved by an affirmative vote of at least
two-thirds of the full Board of Directors before such Business Combination is
submitted for approval to the shareholders or (ii) by an affirmative vote of the
shareholders holding at least two-thirds of the shares of capital stock of the
Company entitled to vote thereon, provided that such Business Combination has
been approved by an affirmative vote of at least a majority of a quorum of the
Board of Directors (but less than two-thirds of the full Board of Directors). In
addition, if the Business Combination is approved by the affirmative vote of the
shareholders holding at least two-thirds of the shares of Common Stock entitled
to vote and by a majority of a quorum of the Board of Directors but less than
two-thirds of the full Board of Directors, the Business Combination must grant
to shareholders not voting to approve the Business Combination certain "fair
price" rights.
 
     The Company's Articles of Incorporation define a Business Combination as
(i) any merger or consolidation of the Company into any other corporation,
person, group, or other entity where the Company is not the surviving or
resulting entity; (ii) any merger or consolidation of the Company with or into
any Control Person or with any corporation, person, group or other entity where
the merger or consolidation is proposed by or on behalf of a Control Person;
(iii) any sale, lease, exchange, or other disposition of all or substantially
all of the assets of the Company; (iv) any sale, lease, exchange, or other
disposition of more than 10% of the total assets of the Company to a Control
Person; (v) the issuance of any securities of the Company to a Control Person;
(vi) the acquisition by the Company of any securities of a Control Person unless
such acquisition begins prior to the person becoming a Control Person or is an
attempt to prevent the Control Person from obtaining greater control of the
Company; (vii) the acquisition by the Company of all or substantially all of the
assets of any Control Person or any entity where the acquisition is proposed by
or on behalf of a Control Person; (viii) the adoption of any plan or proposal
for the liquidation or dissolution of the Company which is proposed by or on
behalf of a Control Person; (ix) any reclassification of securities or
recapitalization of the Company which has the effect of increasing the
proportionate share of the outstanding shares of any class of equity or
convertible securities of the Company which is beneficially owned or controlled
by a Control Person; (x) any of the above transactions which are between the
Company and any of its subsidiaries and which are proposed by or on behalf of
any Control Person; or (xi) any agreement, plan, contract, or other arrangement
providing for any of the above transactions.
 
     The requirement of a supermajority vote of shareholders to approve certain
business transactions, as described above, may discourage a change in control of
the Company by allowing shareholders holding less than a majority of the shares
of Common Stock to prevent a transaction favored by shareholders holding a
majority of such shares. Also, in some circumstances, the Board of Directors
could cause a two-thirds vote to be required to approve a transaction thereby
enabling management to retain control over the affairs of the Company and their
positions with the Company.
 
  Fair Price Provision
 
     The "fair price" provision of the Company's Articles of Incorporation
applies to Business Combinations which have received the approval of two-thirds
of the shareholders entitled to vote but have not received the approval of
two-thirds of the full Board of Directors and only to shareholders who vote
against such Business Combinations and who elect to sell their shares to the
Company for cash at their
 
                                       37
<PAGE>   39
 
fair price. This "fair price" provision requires that the consideration for such
shares be paid in cash by the Company and that the price per share be at least
equal to the greater of the following:
 
          (i) The highest price per share paid for the Company's Common Stock
     during the four years immediately preceding the Business Combination vote
     by any shareholder who beneficially owned five percent or more of the
     Company's Common Stock and who votes in favor of the Business Combination;
 
          (ii) The cash value of the highest price per share previously offered
     pursuant to a tender offer to the shareholders of the Company within the
     four years immediately preceding the Business Combination vote; or
 
          (iii) The highest price per share, including commissions and fees,
     paid by a Control Person in acquiring any of its holdings of the Company's
     Common Stock.
 
     The fair price provision is intended to prevent some of the potential
inequities of two-step takeover attempts by encouraging negotiations with the
Company. However, some shareholders may find the fair price provision
disadvantageous to the extent it discourages changes in control in which
shareholders might receive for at least some of their shares a substantial
premium above the market price at the time an acquisition transaction is made.
 
     The Company is not aware of any pending or threatened effort to acquire
control of the Company or to change management. The Board of Directors does not
presently intend to propose any additional anti-takeover provisions.
 
  Constituencies
 
     The Company's Articles of Incorporation expressly authorize the Board of
Directors of the Company, any committee of the Board of Directors, or any
individual director in determining what is in the best interest of the Company
and its shareholders, to consider, in addition to the long-term and short-term
interests of the shareholders, the social and economic effects of the matter to
be considered on the Company and its subsidiaries, their employees, clients,
creditors, and the communities in which the Company and its subsidiaries operate
or are located. When evaluating a business combination or a proposal by another
person to make a business combination or a tender offer or any other proposal
relating to a potential change in control of the Company, the Board of Directors
may consider such matters as the business and financial condition and earnings
prospects of the acquiring person, and the possible effect of such condition
upon the Company and its subsidiaries and the communities in which the Company
and its subsidiaries operate, the competence, experience, and integrity of the
acquiring person and its management and the prospects for successful conclusion
of the business combination, offer or proposal. The consideration of any of the
above factors is completely discretionary with the Company's Board of Directors.
The constituency provision of the Company's Articles of Incorporation may
discourage or make more difficult certain acquisition proposals or business
combinations and therefore, may adversely affect the ability of shareholders to
benefit from certain transactions opposed by the Company's Board of Directors.
 
  Special Meetings of Shareholders
 
     The Company's Bylaws provide that special meetings of shareholders may be
called only by the Board of Directors, the Chairman of the Board, the President
or holders of 25% or more of the voting power of the outstanding shares of the
Company. As a result, this provision would prevent shareholders owning less than
25% of the voting power of the outstanding Common Stock from compelling
shareholder consideration of any proposal (such as a proposal for a Business
Combination) over the opposition of the Company's Board of Directors.
 
                                       38
<PAGE>   40
 
  Shareholder Proposals
 
     The Company's Bylaws provide that shareholders who desire to bring any
business before a meeting of shareholders must follow specified procedures,
including advance written notice to the Company. The shareholder proposal
provision may make it more difficult for shareholder proposals to be considered
at shareholder meetings.
 
  Transfer Agent and Registrar
 
     The Company's transfer agent and registrar for its Common Stock is First
Union National Bank of North Carolina, Charlotte, North Carolina.
 
                                 LEGAL MATTERS
 
     The validity of the Notes and of the Common Stock issuable upon conversion
thereof offered hereby will be passed upon for the Company by Smith, Anderson,
Blount, Dorsett, Mitchell & Jernigan, L.L.P., Raleigh, North Carolina.
 
                                    EXPERTS
 
   
     The consolidated financial statements of the Company as of December 31,
1996 and 1995 and for each of the three years in the period ended December 31,
1996 included in the Company's Current Report on Form 8-K dated February 7, 1997
incorporated herein by reference have been audited by Ernst & Young LLP,
independent auditors, as set forth in their report thereon included therein and
incorporated by reference herein, which, as to the years 1995 and 1994, are
based in part on the reports of other independent auditors. The consolidated
financial statements of the Company as of December 31, 1995 and 1994 and for the
three years in the period ended December 31, 1995 appearing in the Company's
Annual Report to Shareholders on Form 10-K for the fiscal year ended December
31, 1995 incorporated herein by reference have been audited by Ernst & Young
LLP, independent auditors, as set forth in their report thereon included therein
and incorporated herein by reference. The financial statements of Lewin-VHI as
of and for the year ended December 31, 1995 included in the Company's Current
Report on Form 8-K dated April 16, 1996 have been audited by Ernst & Young, LLP,
independent auditors, as set forth in their report thereon included therein and
incorporated herein by reference. Such financial statements have been
incorporated herein by reference in reliance upon such reports given upon
authority of such firm as experts in accounting and auditing.
    
 
   
     The consolidated financial statements of BRI as of May 31, 1996 and for the
six month period ended May 31, 1996 included in the Registration Statement on
Form S-4, as filed with the Commission under the Securities Act (File No.
333-12573) on September 24, 1996 and amended on October 15, 1996 (the "BRI
Registration Statement"), when such registration statement became effective and
incorporated herein by reference, have been audited by Ernst & Young LLP,
independent auditors, as set forth in their report thereon included therein and
incorporated herein by reference. The consolidated financial statements of BRI
as of November 30, 1995 and 1994 and for each of the two years in the period
ended November 30, 1995 included in the BRI Registration Statement when such
registration statement became effective and incorporated herein by reference
have been audited by Coopers & Lybrand L.L.P., independent accountants, as set
forth in their report thereon included therein and incorporated herein by
reference. Such financial statements have been incorporated herein by reference
in reliance upon such reports given upon authority of such firms as experts in
accounting and auditing.
    
 
   
     The consolidated financial statements of Innovex included in the Company's
Current Report on Form 8-K dated October 6, 1996 and incorporated by reference
herein have been audited by KPMG, independent auditors, as set forth in their
report thereon included therein and incorporated herein by reference. Such
financial statements have been incorporated herein by reference in reliance upon
such reports given upon authority of such firm as experts in accounting and
auditing.
    
 
                                       39
<PAGE>   41
 
   
                           FORWARD LOOKING STATEMENTS
    
 
   
     Information set forth in this Prospectus or incorporated by reference
herein contains various "forward looking statements" within the meaning of
Section 27A of the Securities Act and Section 21E of the Exchange Act, which
statements represent the Company's reasonable judgment concerning the future and
are subject to risks and uncertainties that could cause the Company's actual and
operating results and financial position to differ materially. Such forward
looking statements can be identified by the use of forward looking terminology,
such as "may," "will," "expect," "anticipate," "estimate," "believe" or
"continue" or the negative thereof or comparable terminology.
    
 
   
     The Company cautions that any such forward looking statements are further
qualified by important factors that could cause the Company's actual operating
results to differ materially from those in the forward-looking statements,
including, without limitation those set forth in this Prospectus under "Risk
Factors" and other cautionary elements specified in documents incorporated by
reference in this Prospectus.
    
 
                                       40
<PAGE>   42
 
                                                                      APPENDIX A
 
             NOTICE OF TRANSFER PURSUANT TO REGISTRATION STATEMENT
 
Marine Midland Bank, as Trustee
Quintiles Transnational Corp.
c/o Marine Midland Bank
140 Broadway, 12th Floor
New York, New York 10005
Attention: Corporate Trust Services -- Quintiles
 
          Re: Quintiles Transnational Corp. (the "Company") 4.25% Convertible
              Subordinated Notes due May 31, 2000 (the "Notes")
 
Dear Sirs:
 
   
     Please be advised that                                         has
transferred $          aggregate principal amount of the above-referenced Notes,
or           number of shares of the Company's Common Stock, par value $0.01 per
share (the "Common Stock"), issued upon conversion of the Notes, pursuant to an
effective Registration Statement on Form S-3 (File No. 333-19009) filed by the
Company.
    
 
   
     We hereby certify that the prospectus delivery requirements, if any, of the
Securities Act of 1933, as amended, have been satisfied and that the above-named
beneficial owner of the Notes or Common Stock is named as a "Selling Holder" in
the Prospectus dated             , 1997 or in supplements thereto, and that the
aggregate principal amount of the Notes or shares of Common Stock transferred
are (or are included in) the Notes or shares of Common Stock listed in such
Prospectus opposite such owner's name.
    
 
Dated:
 
                                            Very truly yours,
 
                                            ------------------------------------
                                            (Name)
 
                                        By: ------------------------------------
                                            (Authorized Signature)
 
                                       A-1
<PAGE>   43
 
             ======================================================
 
  NO PERSON HAS BEEN AUTHORIZED TO GIVE ANY INFORMATION OR TO MAKE ANY
REPRESENTATIONS OTHER THAN THOSE CONTAINED IN THIS PROSPECTUS AND, IF GIVEN OR
MADE, SUCH INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON AS HAVING BEEN
AUTHORIZED BY THE COMPANY. THIS PROSPECTUS DOES NOT CONSTITUTE AN OFFER TO SELL
OR THE SOLICITATION OF AN OFFER TO BUY ANY SECURITIES OTHER THAN THE REGISTERED
SECURITIES TO WHICH IT RELATES OR AN OFFER TO SELL OR THE SOLICITATION OF AN
OFFER TO BUY SUCH SECURITIES BY ANY PERSON IN ANY CIRCUMSTANCES IN WHICH SUCH
OFFER OR SOLICITATION IS UNLAWFUL. NEITHER THE DELIVERY OF THIS PROSPECTUS NOR
ANY SALE MADE HEREUNDER SHALL, UNDER ANY CIRCUMSTANCES, CREATE ANY IMPLICATION
THAT THERE HAS BEEN NO CHANGE IN THE AFFAIRS OF THE COMPANY SINCE THE DATE
HEREOF OR THAT THE INFORMATION HEREIN IS CORRECT AS OF ANY TIME SUBSEQUENT TO
ITS DATE.
 
                             ---------------------
 
                               TABLE OF CONTENTS
 
   
<TABLE>
<CAPTION>
                                        PAGE
                                        ----
<S>                                     <C>
Incorporation of Certain Documents by
  Reference...........................    2
Available Information.................    2
Summary...............................    3
Risk Factors..........................    7
Ratio of Earnings to Fixed Charges....   11
The Company...........................   12
Use of Proceeds.......................   12
Selling Holders.......................   13
Plan of Distribution..................   15
Description of Notes..................   17
Certain Federal Income Tax
  Considerations......................   33
Description of Capital Stock..........   35
Legal Matters.........................   39
Experts...............................   39
Forward-Looking Statements............   40
Appendix A............................  A-1
</TABLE>
    
 
             ======================================================
             ======================================================
                         QUINTILES TRANSNATIONAL CORP.
                             ---------------------
 
                                   PROSPECTUS
 
                             ---------------------
   
                                                                          , 1997
    
             ======================================================
<PAGE>   44
 
                                    PART II
 
                     INFORMATION NOT REQUIRED IN PROSPECTUS
 
ITEM 14.  OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION
 
     The following table sets forth an itemized statement of all estimated
expenses in connection with the issuance and distribution of the securities
being registered.
 
   
<TABLE>
<S>                                                           <C>
SEC Registration Fee........................................  $ 38,205
Nasdaq Listing Fee..........................................    17,500*
Legal Fees and Expenses.....................................   183,455
Accounting Fees and Expenses................................    44,750
Printing and Engraving Expenses.............................    33,547
Miscellaneous Expenses......................................   188,793
                                                              --------
          Total.............................................  $506,250
                                                              ========
</TABLE>
    
 
- ---------------
 
* Payable upon official notice of the first conversion.
 
ITEM 15.  INDEMNIFICATION OF DIRECTORS AND OFFICERS
 
     Sections 55-8-50 through 55-8-58 of the North Carolina Business Corporation
Act permit a corporation to indemnify its directors, officers, employees or
agents under either or both a statutory or non-statutory scheme of
indemnification. Under the statutory scheme, a corporation may, with certain
exceptions, indemnify a director, officer, employee or agent of the corporation
who was, is, or is threatened to be made, a party to any threatened, pending or
completed legal action, suit or proceeding, whether civil, criminal,
administrative, or investigative, because of the fact that such person was a
director, officer, agent or employee of the corporation, or is or was serving at
the request of such corporation as a director, officer, employee or agent of
another corporation or enterprise. This indemnity may include the obligation to
pay any judgment, settlement, penalty, fine (including an excise tax assessed
with respect to an employee benefit plan) and reasonable expenses incurred in
connection with the proceeding (including counsel fees), but no such
indemnification may be granted unless such director, officer, agent or employee
(i) conducted himself in good faith, (ii) reasonably believed (1) that any
action taken in his official capacity with the corporation was in the best
interest of the corporation or (2) that in all other cases his conduct at least
was not opposed to the corporation's best interest, and (iii) in the case of any
criminal proceeding, had no reasonable cause to believe his conduct was
unlawful. Whether a director has met the requisite standard of conduct for the
type of indemnification set forth above is determined by the board of directors,
a committee of directors, special legal counsel or the shareholders in
accordance with Section 55-8-55. A corporation may not indemnify a director
under the statutory scheme in connection with the proceeding by or in the right
of the corporation in which the director was adjudged liable to the corporation
or in connection with the proceeding in which a director was adjudged liable on
the basis of having received an improper personal benefit.
 
     In addition to, and separate and apart from the indemnification described
above under the statutory scheme, Section 55-8-57 of the North Carolina Business
Corporation Act permits a corporation to indemnify or agree to indemnify any of
its directors, officers, employees or agents against liability and expenses
(including attorneys fees) in any proceeding (including proceedings brought by
or on behalf of the corporation) arising out of their status as such or their
activities in such capacities, except for any liabilities or expenses incurred
on account of activities that were, at the time taken, known or believed by the
person to be clearly in conflict with the best interests of the corporation. The
Company's bylaws provide for indemnification to the fullest extent permitted
under the North Carolina Business Corporation Act, provided, however, that the
Company will indemnify any person seeking indemnification in connection with a
proceeding initiated by such person only if such proceeding was authorized by
the
 
                                      II-1
<PAGE>   45
 
Board of Directors of the Company. Accordingly, the Company may indemnify its
directors, officers, and employees in accordance with either the statutory or
non-statutory standard.
 
     Sections 55-8-52 and 55-8-56 of the North Carolina Business Corporation Act
require a corporation, unless its articles of incorporation provide otherwise,
to indemnify a director or officer who has been wholly successful, on the merits
or otherwise, in the defense of any proceeding to which such director or officer
was a party. Unless prohibited by the articles of incorporation, a director or
officer also may make application and obtain court-ordered indemnification if
the court determines that such director or officer is fairly and reasonably
entitled to such indemnification as provided in Sections 55-8-54 and 55-8-56.
 
     Finally, Section 55-8-57 of the North Carolina Business Corporation Act
provides that a corporation may purchase and maintain insurance on behalf of an
individual who is or was a director, officer, employee or agent of the
corporation against certain liabilities incurred by such persons, whether or not
the corporation is otherwise authorized by the North Carolina Business
Corporation Act to indemnify such party. The Company's directors and officers
are currently covered under directors' and officers' insurance policies
maintained by the Company.
 
     As permitted by North Carolina law, Article XI of the Company's Articles of
Incorporation limits the personal liability of directors for monetary damages
for breaches of duty as a director provided that such limitation will not apply
to (i) acts or omissions that the director at the time of the breach knew or
believed were clearly in conflict with the best interests of the Company, (ii)
any liability for unlawful distributions under N.C. Gen. Stat. Section 55-8-33,
(iii) any transaction from which the director derived an improper personal
benefit or (iv) acts or omissions occurring prior to the date the provision
became effective.
 
                                      II-2
<PAGE>   46
 
ITEM 16.  EXHIBITS
 
     The following documents (unless indicated) are filed herewith and made a
part of this Registration Statement.
 
   
<TABLE>
<CAPTION>
EXHIBIT
  NO.                                DESCRIPTION
- -------                              -----------
<C>          <S>
  4.01(1)    Specimen Common Stock Certificate
  4.02*      Amended and Restated Articles of Incorporation
  4.03(2)    Amended and Restated Bylaws
  4.04(3)    Indenture, dated as of May 17, 1996, between the Company and
             Marine Midland Bank, as Trustee, with respect to the
             Company's 4.25% Convertible Subordinated Notes due May 31,
             2000
  4.05*      Form of the Company's 4.25% Convertible Subordinated Notes
             in Unrestricted Global Form
  4.06*      Form of the Company's 4.25% Convertible Subordinated Notes
             in Certificated Form
  5.01       Opinion of Smith, Anderson, Blount, Dorsett, Mitchell &
             Jernigan, L.L.P.
 12.01       Computation of Ratio of Earnings to Fixed Charges
 23.01       Consent of Ernst & Young, LLP
 23.02       Consent of Coopers & Lybrand L.L.P.
 23.03       Consent of KPMG
 23.04       Consent of Smith, Anderson, Blount, Dorsett, Mitchell &
             Jernigan, L.L.P. (included in Exhibit 5.01 hereto)
 24.01*      Powers of Attorney
 25.01*      Statement of Eligibility of Trustee
 99.01(3)    Registration Rights Agreement, dated as of May 17, 1996, by
             and among the Company, Goldman Sachs International and Smith
             Barney Inc.
</TABLE>
    
 
- ---------------
 
   
 *  Previously Filed.
    
(1) Exhibit to the Company's Registration Statement on Form S-1 as filed with
     the Securities and Exchange Commission (Registration No. 33-75766)
     effective April 20, 1994 and incorporated herein by reference.
   
(2) Exhibit to the Company's Annual Report on Form 10-K (as amended by Form
     10-K/A on May 16, 1996) as filed with the Securities and Exchange
     Commission on March 25, 1996 and incorporated herein by reference.
    
(3) Exhibit to the Company's Quarterly Report on Form 10-Q as filed with the
     Securities and Exchange Commission on August 15, 1996 and incorporated
     herein by reference.
 
                                      II-3
<PAGE>   47
 
ITEM 17.  UNDERTAKINGS
 
     The undersigned registrant hereby undertakes:
 
          (1) To file during, any period in which offers and sales are being
     made, a post-effective amendment to this registration statement:
 
             (i) To include any prospectus required by Section 10(a)(3) of the
        Securities Act of 1933;
 
             (ii) To reflect in the prospectus any facts or events arising after
        the effective date of the registration statement (or the most recent
        post-effective amendment thereof) which, individually or in the
        aggregate, represent a fundamental change in the information set forth
        in the registration statement. Notwithstanding the foregoing, any
        increase or decrease in volume of securities offered (if the total
        dollar value of securities offered would not exceed that which was
        registered) and any deviation from the low or high end of the estimated
        maximum offering range may be reflected in the form of the prospectus
        filed with the Commission pursuant to Rule 424(b) if, in the aggregate,
        the changes in volume and price represent no more than a 20% change in
        the maximum aggregate offering price set forth in the "Calculation of
        Registration Fee" table in the effective registration statement; and
 
             (iii) To include any material information with respect to the plan
        of distribution not previously disclosed in the registration statement
        or any material change to such information in the registration
        statement.
 
     Provided, however, that paragraphs (1)(i) and (1)(ii) of this section do
     not apply if the registration statement is on Form S-3, Form S-8 or Form
     F-3, and the information required to be included in a post-effective
     amendment by those paragraphs is contained in periodic reports filed with
     or furnished to the Commission by the registrant pursuant to section 13 or
     section 15(d) of the Securities Exchange Act of 1934 that are incorporated
     by reference in the registration statement.
 
          (2) That, for the purpose of determining any liability under the
     Securities Act of 1933, each such post-effective amendment shall be deemed
     to be a new registration statement relating to the securities offered
     therein, and the offering of such securities at that time shall be deemed
     to be the initial bona fide offering thereof.
 
          (3) To remove from registration by means of a post-effective amendment
     any of the securities being registered which remain unsold at the
     termination of the offering.
 
     The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to Section 13(a) or Section 15(d) of the
Securities and Exchange Act of 1934 (and, where applicable, each filing of an
employee benefit plan's annual report pursuant to Section 15(d) of the
Securities Exchange Act of 1934) that is incorporated by reference in the
registration statement shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.
 
     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Act and is,
therefore, unenforceable. In the event that a claim for indemnification against
such liabilities (other than the payment by the registrant of expenses incurred
or paid by a director, officer or controlling person of the registrant in the
successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final adjudication of
such issue.
 
                                      II-4
<PAGE>   48
 
                                   SIGNATURES
 
   
     Pursuant to the requirements of the Securities Act, the registrant has duly
caused this registration statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in the City of Durham, State of North
Carolina, on February 18, 1997.
    
 
                                          QUINTILES TRANSNATIONAL CORP.
 
   
                                          By: /s/ DENNIS B. GILLINGS
    
                                            ------------------------------------
   
                                            Dennis B. Gillings
    
   
                                            Chairman of the Board of Directors
    
   
                                            and Chief Executive Officer
    
 
                                      II-5
<PAGE>   49
 
   
     Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed by the following persons as of
February 18, 1997 in the capacities indicated.
    
 
   
<TABLE>
<CAPTION>
                      SIGNATURE                                              TITLE
                      ---------                                              -----
<C>                                                      <S>
 
               /s/ DENNIS B. GILLINGS                    Chairman of the Board of Directors and Chief
- -----------------------------------------------------      Executive Officer
                 Dennis B. Gillings
 
                          *                              President, Chief Operating Officer and
- -----------------------------------------------------      Director
                   Santo J. Costa
 
               /s/ RACHEL R. SELISKER                    Chief Financial Officer, Executive Vice
- -----------------------------------------------------      President Finance, Treasurer and Director
                 Rachel R. Selisker                        (Principal Accounting and Financial Officer)
 
                                                         Director
- -----------------------------------------------------
                   Barrie S. Haigh
 
                                                         Director
- -----------------------------------------------------
                     Paul Knott
 
                          *                              Director
- -----------------------------------------------------
                  Ludo J. Reynders
 
                          *                              Director
- -----------------------------------------------------
                   Eric J. Souetre
 
                          *                              Director
- -----------------------------------------------------
                 Richard H. Thompson
 
                          *                              Director
- -----------------------------------------------------
                 Chester W. Douglass
 
                          *                              Director
- -----------------------------------------------------
                    John G. Fryer
 
                          *                              Director
- -----------------------------------------------------
                  Arthur M. Pappas
 
                          *                              Director
- -----------------------------------------------------
                  Robert C. Bishop
 
                                                         Director
- -----------------------------------------------------
                   Lawrence Lewin

*By:           /s/ RACHEL R. SELISKER                    By:          /s/ DENNIS B. GILLINGS
    -----------------------------------------------         --------------------------------------------
       Rachel R. Selisker as Attorney-in-Fact                  Dennis B. Gillings as Attorney-in-Fact
</TABLE>
    
 
                                      II-6
<PAGE>   50
 
                               INDEX TO EXHIBITS
 
   
<TABLE>
<CAPTION>
EXHIBIT
NUMBER                          DESCRIPTION OF EXHIBIT
- -------                         ----------------------
<C>          <S>
  4.01(1)    Specimen Common Stock Certificate
  4.02*      Amended and Restated Articles of Incorporation
  4.03(2)    Amended and Restated Bylaws
  4.04(3)    Indenture, dated as of May 17, 1996, between the Company and
             Marine Midland Bank, as Trustee, with respect to the
             Company's 4.25% Convertible Subordinated Notes due May 31,
             2000
  4.05*      Form of the Company's 4.25% Convertible Subordinated Notes
             in Unrestricted Global Form
  4.06*      Form of the Company's 4.25% Convertible Subordinated Notes
             in Certificated Form
  5.01       Opinion of Smith, Anderson, Blount, Dorsett, Mitchell &
             Jernigan, L.L.P.
 12.01       Computation of Ratio of Earnings to Fixed Charges
 23.01       Consent of Ernst & Young, LLP
 23.02       Consent of Coopers & Lybrand L.L.P.
 23.03       Consent of KPMG
 23.04       Consent of Smith, Anderson, Blount, Dorsett, Mitchell &
             Jernigan, L.L.P. (included in Exhibit 5.01 hereto)
 24.01*      Powers of Attorney
 25.01*      Statement of Eligibility of Trustee
 99.01(3)    Registration Rights Agreement, dated as of May 17, 1996, by
             and among the Company, Goldman Sachs International and Smith
             Barney Inc.
</TABLE>
    
 
- ---------------
 
   
 *  Previously Filed.
    
(1) Exhibit to the Company's Registration Statement on Form S-1 as filed with
     the Securities and Exchange Commission (Registration No. 33-75766)
     effective April 20, 1994 and incorporated herein by reference.
   
(2) Exhibit to the Company's Annual Report on Form 10-K (as amended by Form
     10-K/A on May 16, 1996) as filed with the Securities and Exchange
     Commission on March 25, 1996 and incorporated herein by reference.
    
(3) Exhibit to the Company's Quarterly Report on Form 10-Q as filed with the
     Securities and Exchange Commission on August 15, 1996 and incorporated
     herein by reference.

<PAGE>   1

                                                                  Exhibit 5.01




   
                               February 17, 1997

    





                                                                (919) 821-6668




Quintiles Transnational Corp.
4709 Creekstone Drive
Riverbirch Building, Suite 300
Durham, North Carolina  27703

Ladies and Gentlemen:

   
         As counsel for Quintiles Transnational Corp. (the "Company"), we
furnish the following opinion in connection with the preparation of the
Company's Registration Statement on Form S-3 (No. 333-19009) filed with the
Securities and Exchange Commission (the "Commission") under the Securities Act
of 1933, as amended (the "Act"), on December 30, 1996, and amended February 17,
1997, relating to the registration for the accounts of the holders named in the
Registration Statement of (a) $126,075,000 principal amount of the Company's
4.25% Convertible Subordinated Notes Due May 31, 2000 (the "Notes") and (b)
1,523,565 shares (the "Shares") of the Company's common stock, par value $.01
per share, that are issuable by the Company upon conversion of the Notes.  The
Notes have been issued pursuant to an Indenture entered into between the Company
and Marine Midland Bank, as trustee (the "Indenture").  This opinion is
furnished pursuant to the requirement of Item 601(b)(5) of Regulation S-K under
the Act.  This opinion supersedes and replaces the opinion of our firm dated
December 30, 1996 which was filed as Exhibit 5.01 to the Registration Statement
as filed with the Commission on December 30, 1996.
    

         We have examined the Amended and Restated Articles of Incorporation,
as amended, and the Amended and Restated Bylaws of the Company, the Indenture,
the Registration Statement, the minutes of meetings of the Company's Board of
Directors, and such other corporate records of the Company and other documents
<PAGE>   2

   
Quintiles Transnational Corp.
February 17, 1997
Page 2
    



and have made such examinations of law as we have deemed relevant for purposes
of this opinion.

         Based on and subject to the foregoing and to the additional
qualifications set forth below, it is our opinion that (a) the Notes that are
being offered pursuant to the Registration Statement have been legally issued
in accordance with the Indenture and, assuming due delivery against payment
therefor when the Notes were issued, are binding obligations  of the Company,
and (b) the Shares, when issued by the Company in accordance with the Company's
Amended and Restated Articles of Incorporation, as amended, and its Amended and
Restated Bylaws, will be legally issued and, assuming due delivery against
payment therefor when the Shares are issued upon the conversion of the Notes,
will be fully paid and nonassessable

         We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement.  Such consent shall not be deemed to be an admission
that this firm is within the category of persons whose consent is required
under Section 7 of the Act or the regulations promulgated pursuant to the Act.

         This opinion is limited to the laws of the State of North Carolina and
no opinion is expressed as to the laws of any other jurisdiction, including
without limitation, with respect to the enforceability of the Indenture and 
the Notes under New York law.

         Our opinion is as of the date hereof, and we do not undertake to
advise you of matters which might come to our attention subsequent to the date
hereof which may affect our legal opinion expressed herein.

                                Sincerely yours,

                                        SMITH, ANDERSON, BLOUNT, DORSETT,
                                                  MITCHELL & JERNIGAN, L.L.P.



                                        By: /s/ Gerald F. Roach
                                            Gerald F. Roach
  

GFR/dto

<PAGE>   1


                                                                  EXHIBIT 12.01


   
                        QUINTILES TRANSNATIONAL CORP.

             COMPUTATION OF RATIO OF EARNINGS TO FIXED CHARGES(1)


<TABLE>
<CAPTION>
                                                                          
                                     Year Ended December 31,                
                            -----------------------------------------     
                            1992      1993     1994     1995     1996(2)     
                            ----      ----     ----     ----     -------     
                                         (in thousands)
<S>                        <C>      <C>      <C>       <C>       <C>      
Pre-tax income             $5,304   $ 7,617  $13,632   $22,082   $17,125

Interest                    1,285     2,686    2,795     3,765     8,908

Interest portion of
 rental expense               343       633      736     1,064     2,167

Amortization of debt
 expense and discount
 and premium                    0         0        0         0       618
                           ------   -------  -------   -------   -------  

Adjusted Earnings          $6,932   $10,936  $17,163   $26,911   $28,818
                           ======   =======  =======   =======   =======  

Interest                   $1,285   $ 2,686  $ 2,795   $ 3,765   $ 8,908

Interest portion of
 rental expense               343       633      736     1,064     2,167

Amortization of debt
 expense and discount
 and premium                    0         0        0         0       618
                           ------   -------  -------   -------   -------  

    Fixed Charges          $1,628   $ 3,319  $ 3,531   $ 4,829   $11,693
                           ======   =======  =======   =======   =======  

Ratio of Earnings to
 Fixed Charges               4.26      3.29     4.86      5.57      2.46
                           ======   =======  =======   =======   =======  

</TABLE>

- ------------
(1) Computations include all periods presented for Quintiles Transnational Corp.
    restated to include the effects of pooling of interests transactions 
    effected with BRI International, Inc. and Innovex Limited in November 1996.

(2) The ratio of earnings to fixed charges would be 4.85 if the computation of
    the ratio were to exclude non-recurring charges for transaction and
    restructuring costs of $27.847 million in 1996 from pre-tax income.
    

<PAGE>   1

                                                                   EXHIBIT 23.01

   
                       CONSENT OF INDEPENDENT AUDITORS

We consent to the reference to our firm under the caption "Experts" in Amendment
No. 1 to the Registration Statement on Form S-3 (No. 333-19009) and related
Prospectus of Quintiles Transnational Corp. (the "Company") for the registration
of $126,075,000 of its 4.25% Convertible Subordinated Notes Due May 31, 2000 and
1,523,565 shares of its Common Stock and to the  incorporation by reference
therein of (i) our report dated January 29, 1997 with respect to the
consolidated financial statements of the Company as of December 31, 1996 and
1995 and for the three years in the period ended December 31, 1996 included in
the Company's Current Report on Form 8-K, dated February 7, 1997, (ii) our
report dated January 30, 1996, with respect to the consolidated financial
statements of the Company incorporated by reference in its Annual Report on Form
10-K for the year ended December 31, 1995, (iii) our report dated April 11, 1996
with respect to the financial statements of Lewin-VHI, a subsidiary of Value
Health, Inc., for the year ended December 31, 1995 incorporated by reference
from the Company's Current Report on Form 8-K, dated April 16, 1996 and (iv) our
report dated August 2, 1996 with respect to the consolidated financial
statements of BRI International, Inc. for the six month period ended May 31,
1996 incorporated by reference from Amendment No. 1 to the Company's
Registration Statement on Form S-4 (No. 333-12573) dated October 15, 1996 filed
with the Securities and Exchange Commission.




                                           /s/ Ernst & Young LLP


Raleigh, North Carolina
February 17, 1997
    






<PAGE>   1

                                                                   EXHIBIT 23.02

                       CONSENT OF INDEPENDENT ACCOUNTANTS


   
We consent to the incorporation by reference in Amendment No. 1 to the
Registration Statement of Quintiles Transnational Corp. ("Quintiles") on Form
S-3 (File No. 333-19009) of our report dated May 15, 1996, on our audits of the
consolidated financial statements of BRI International, Inc. as of November 30,
1995 and 1994, and for the years then ended, which report is included in
Quintiles' Registration Statement on Form S-4 (File No. 333-12573).  We also
consent to the reference to our firm under the caption "Experts."




                                             /s/ Coopers & Lybrand L.L.P.

                                                 Coopers & Lybrand L.L.P.

Rockville, Maryland
February 17, 1997
    





<PAGE>   1

                                                                   EXHIBIT 23.03

                        CONSENT OF INDEPENDENT AUDITORS


   
We consent to the incorporation by reference in Amendment No. 1 to the 
Registration Statement on Form S-3 of Quintiles Transnational Corp. in respect
of 4.25% convertible subordinated notes due May 31, 2000 of our  report dated
July 24, 1996, with respect to the financial statements of the Innovex
Companies included in the Current Report on Form 8-K of Quintiles Transnational
Corp. dated October 6, 1996 and to the reference to our firm under the caption
"Experts" in Amendment No. 1 to the Registration Statement.





/s/ KPMG
KPMG
Reading, England
                                                             February 17, 1997
    









© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission