QUINTILES TRANSNATIONAL CORP
DEF 14A, 2000-05-22
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1
                            SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant  [X]
Filed by a Party other than the Registrant  [ ]

Check the appropriate box:

[ ]      Preliminary Proxy Statement
[ ]      Confidential, for use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
[X]      Definitive Proxy Statement
[ ]      Definitive Additional Materials
[ ]      Soliciting Material Pursuant to Rule 14a-11(c) or rule 14a-12

                          QUINTILES TRANSNATIONAL CORP.
                          -----------------------------
                (Name of Registrant as Specified In Its Charter)

                                 Not Applicable
                                 --------------
     (Name of Person(s) Filing Proxy Statement if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]      No fee required.

[ ]      Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and
         0-11.

         (1)      Title of each class of securities to which transaction
                  applies:

         (2)      Aggregate number of securities to which transaction applies:

         (3)      Per unit price or other underlying value of transaction
                  computed pursuant to Exchange Act Rule 0-11 (set forth the
                  amount on which the filing fee is calculated and state how it
                  was determined):

         (4)      Proposed maximum aggregate value of transaction:

         (5)      Total fee paid:

[ ]      Fee paid previously with preliminary materials.


[ ]      Check box if any part of the fee is offset as provided by Exchange Act
         Rule 0-11(a)(2) and identify the filing for which the offsetting fee
         was paid previously. Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.

         (1)      Amount Previously Paid:
         (2)      Form, Schedule or Registration Statement No.:
         (3)      Filing Party:
         (4)      Date Filed:


<PAGE>   2

                                [Quintiles Logo]


                              4709 CREEKSTONE DRIVE
                         RIVERBIRCH BUILDING, SUITE 200
                        DURHAM, NORTH CAROLINA 27703-8411

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

                            TO BE HELD JUNE 19, 2000

         You are cordially invited to attend the Annual Meeting of Shareholders
of Quintiles Transnational Corp. (the "Company") which will be held on Monday,
June 19, 2000 at 5:00 p.m., Eastern Daylight Saving Time, at the Marriott at
Research Triangle Park, 4700 Guardian Dr., Durham, North Carolina 27703 for the
following purposes:

         (1)      To elect four nominees to serve as Class III directors with
                  terms continuing until the Annual Meeting of Shareholders in
                  2003;

         (2)      To approve the Company's 1999 Employee Stock Purchase Plan;

         (3)      To ratify the appointment of Arthur Andersen LLP as
                  independent public accountants for the Company and its
                  subsidiaries for the fiscal year ending December 31, 2000; and

         (4)      To transact such other business as may properly come before
                  the meeting or any adjournment thereof.

         Shareholders of record at the close of business on May 4, 2000 are
entitled to notice of and to vote at the Annual Meeting and any and all
adjournments or postponements thereof.

         IT IS DESIRABLE THAT YOUR SHARES OF STOCK BE REPRESENTED AT THE MEETING
         REGARDLESS OF THE NUMBER OF SHARES YOU MAY HOLD. WHETHER OR NOT YOU
         PLAN TO ATTEND THE MEETING IN PERSON, PLEASE COMPLETE AND RETURN THE
         ENCLOSED PROXY IN THE ENVELOPE PROVIDED. IF YOU ATTEND THE MEETING YOU
         MAY REVOKE YOUR PROXY AND VOTE IN PERSON.

                                    By Order of the Board of Directors

                                    John S. Russell
                                    Senior Vice President and General Counsel
                                    Head Global Human Resources,
                                    Corporate Secretary

Durham, North Carolina
May 22, 2000


<PAGE>   3
                          QUINTILES TRANSNATIONAL CORP.

                              4709 CREEKSTONE DRIVE
                         RIVERBIRCH BUILDING, SUITE 200
                        DURHAM, NORTH CAROLINA 27703-8411

                                 PROXY STATEMENT

                               GENERAL INFORMATION

PROXY SOLICITATION

         This Proxy Statement and the accompanying proxy card are being mailed
to shareholders on or about May 22, 2000, by the Board of Directors of Quintiles
Transnational Corp. (the "Company") in connection with the solicitation of
proxies for use at the Annual Meeting of Shareholders (the "Annual Meeting") to
be held at the Marriott at Research Triangle Park, 4700 Guardian Dr., Durham,
North Carolina 27703 on June 19, 2000, at 5:00 p.m., Eastern Daylight Saving
Time, and at all adjournments or postponements thereof. The Company will pay all
expenses incurred in connection with this solicitation, including postage,
printing, handling and the actual expenses incurred by custodians, nominees and
fiduciaries in forwarding proxy material to beneficial owners. In addition to
solicitation by mail, certain officers, directors and regular employees of the
Company, who will receive no additional compensation for their services, may
solicit proxies by telephone, personal communication or other means. The Company
has retained Corporate Investor Communications, Inc. to aid in the search for
shareholders and delivery of proxy materials.

PURPOSES OF MEETING

         The principal purposes of the meeting are to: (1) elect four Class III
directors for a term of three years; (2) approve the Company's 1999 Employee
Stock Purchase Plan; (3) ratify the action of the Board of Directors pursuant to
the recommendation of the Audit Committee in appointing Arthur Andersen LLP as
independent public accountants for the Company and its subsidiaries for the 2000
fiscal year; and (4) transact such other business as may properly come before
the meeting or any adjournment or postponement thereof. The Board of Directors
knows of no other matters other than those stated above to be brought before the
meeting.

VOTING RIGHTS

         If the accompanying proxy card is properly signed and returned to the
Company and not revoked, it will be voted in accordance with the instructions
contained therein. If the proxy card is signed and returned, but voting
directions are not made, the proxy will be voted in favor of the proposals set
forth in the accompanying "Notice of Annual Meeting of Shareholders" and in such
manner as the proxyholders named on the enclosed proxy card in their discretion
determine upon such other business as may properly come before the meeting or
any adjournment or




<PAGE>   4

postponement thereof. Any proxy given pursuant to this solicitation may be
revoked by the person giving it at any time before it is voted by (1) filing
written notice of revocation with the Secretary of the Company which is actually
received prior to the vote of shareholders, (2) filing a duly executed proxy
bearing a later date with the Secretary of the Company before the vote of
shareholders or (3) attending the Annual Meeting and voting in person.

         The Board of Directors has fixed the close of business on May 4, 2000,
as the record date for the determination of shareholders entitled to receive
notice of and to vote at the Annual Meeting and all adjournments or
postponements thereof. As of the close of business on May 4, 2000, the Company
had outstanding 115,118,536 shares of Common Stock. On all matters to come
before the Annual Meeting, each holder of Common Stock will be entitled to vote
at the Annual Meeting and will be entitled to one vote for each share owned.

                          SHARE OWNERSHIP OF MANAGEMENT

SHARE OWNERSHIP OF MANAGEMENT

         The following table provides information, as of March 31, 2000,
regarding shares of Common Stock of the Company owned of record or known to the
Company to be owned beneficially by each director, each executive officer named
in the Summary Compensation Table on page 13 and all current directors and
executive officers as a group. Except as set forth in the footnotes, each of the
shareholders identified in the table below has sole voting and investment power
over the shares beneficially owned by such person, except to the extent such
power may be shared with a spouse.

<TABLE>
<CAPTION>
                                                                           Shares                Percent
        Name                                                        Beneficially Owned(1)        of Class
        ----                                                        ------------------           --------
        <S>                                                         <C>                          <C>
        Dennis B. Gillings, Ph.D. (2)                                     6,112,530                 5.3%
        Santo J. Costa (3)                                                  320,090                   *
        Ludo Reynders (4)                                                   227,085                   *
        Rachel R. Selisker (5)                                              171,382                   *
        William E. Ford (6)                                               2,813,757                 2.4%
        Fred C. Goad, Jr. (7)                                               928,467                   *
        Jim D. Kever (8)                                                  1,018,226                   *
        Robert C. Bishop, Ph.D. (9)                                          36,345                   *
        Chester W. Douglass, Ph.D. (10)                                     367,693                   *
        Arthur M. Pappas (11)                                                79,943                   *
        Vaughn D. Bryson (12)                                                15,585                   *
        Virginia V. Weldon, M.D. (13)                                         9,601                   *
        Eric J. Topol, M.D. (14)                                              8,727                   *
        E.G.F. Brown (15)                                                    14,493                   *

        All current directors and executive officers as a                11,750,508                10.0%
        group (14 persons) (16)
</TABLE>

- -------------------------
*Less than one percent


                                       2
<PAGE>   5

(1)      Pursuant to the rules of the Securities and Exchange Commission,
         certain shares of the Company's Common Stock which a person has the
         right to acquire within 60 days of the date shown above pursuant to the
         exercise of stock options are deemed to be outstanding for the purpose
         of computing the percentage ownership of such person but are not deemed
         outstanding for the purpose of computing the percentage ownership of
         any other person. Such shares are described below as being subject to
         presently exercisable stock options. A beneficial owner of shares held
         in the Company's Employee Stock Ownership Plan (the "ESOP") or Approved
         Profit Sharing Scheme has sole voting power over the shares held in his
         or her account, but shares investment power over the shares with the
         plan trustee.
(2)      Includes 183,370 shares subject to presently exercisable stock options
         and 161,219 shares held by the ESOP for Dr. Gillings' account. Includes
         6,739 shares owned by Dr. Gillings' daughter, 180,000 shares owned by
         the Gillings Family Limited Partnership, of which Dr. Gillings and his
         wife are the general partners, 7,200 shares held by the GFEF Limited
         Partnership, of which Dr. Gillings is the general partner, 198,618
         shares owned by Dr. Gillings' wife and an aggregate of 834,766 shares
         owned by two Grantor Retained Annuity Trusts under which Dr. Gillings
         is the beneficiary. Dr. Gillings shares voting power over 392,557
         shares and shares investment power over 1,388,542 shares. Dr. Gillings
         disclaims beneficial ownership of all shares owned by his wife and
         daughter, all shares in the Gillings Family Limited Partnership, all
         shares owned by the GFEF Limited Partnership and all shares in the
         GRATs, except to the extent of his interest therein.
(3)      Includes 293,395 shares subject to presently exercisable stock options
         and 3,645 shares held by the ESOP for Mr. Costa's account. Includes
         1,000 shares owned by Mr. Costa's wife and 200 shares owned by Mr.
         Costa's children. Mr. Costa disclaims beneficial ownership of the
         shares held by his wife.
(4)      Includes 112,971 shares subject to presently exercisable stock options,
         702 shares held by Quintiles (UK) Limited Approved Profit Sharing
         Scheme for Dr. Reynders' account and 166 shares held by the ESOP for
         Dr. Reynders' account.
(5)      Includes 81,949 shares subject to presently exercisable stock options
         and 44,069 shares held by the ESOP for Ms. Selisker's account.
(6)      Includes 3,958 shares subject to presently exercisable stock options.
         Also includes 2,425,631 shares owned by General Atlantic Partners 25,
         L.P. ("GAP 25"), whose general partner is General Atlantic Partners,
         LLC ("GAP LLC"). Mr. Ford is a managing member of GAP LLC. Includes
         384,168 shares owned by GAP Coinvestment Partners, L.P. ("GAPCO"), of
         which Mr. Ford is a general partner. GAP 25, GAP LLC and GAPCO are a
         "group" within the meaning of Rule 13d-5 of the Securities and Exchange
         Act of 1934, as amended. Mr. Ford disclaims beneficial ownership of all
         such securities except to the extent of his pecuniary interest therein.
(7)      Includes 623,810 shares subject to presently exercisable stock options.
         Includes 15,304 shares owned by Mr. Goad's wife and 83,468 shares held
         in trusts of which Mr. Goad is the trustee and primary beneficiary. Mr.
         Goad disclaims beneficial ownership of the shares held by his wife.
(8)      Includes 635,470 shares subject to presently exercisable stock options
         and 63,960 shares in a trust for the benefit of Mr. Kever's minor
         children.
(9)      Includes 33,845 shares subject to presently exercisable stock options.


                                       3
<PAGE>   6
(10)     Includes 36,593 shares subject to presently exercisable stock options.
         Includes 93,600 shares owned by the Douglass Family Limited
         Partnership, of which Dr. Douglass is the sole general partner. Dr.
         Douglass disclaims beneficial ownership of the shares held by the
         limited partnership except to the extent of his pecuniary interest
         therein.
(11)     Includes 33,843 shares subject to presently exercisable stock options.
(12)     Includes 12,585 shares subject to presently exercisable stock options.
(13)     Includes 8,601 shares subject to presently exercisable stock options.
         Includes 1,000 shares held in a trust.
(14)     Includes 8,727 shares subject to presently exercisable stock options.
(15)     Includes 6,493 shares subject to presently exercisable stock options.
(16)     Does not include shares beneficially owned by named executive officers
         who are not executive officers as of the date of this report. Includes
         1,904,884 shares subject to presently exercisable stock options and
         165,198 shares held by the ESOP for the accounts of individual
         executive officers.

STOCK OWNERSHIP OF CERTAIN BENEFICIAL OWNERS

         The following table provides information regarding shares of the
Company's Common Stock known to be beneficially owned by persons holding more
than five percent of the Company's outstanding Common Stock (other than
directors and executive officers shown in the preceding table) as of March 31,
2000.

<TABLE>
<CAPTION>
                                                         SHARES BENEFICIALLY          PERCENT OF
     NAME AND ADDRESS OF BENEFICIAL OWNER                        OWNED                  CLASS
     ------------------------------------                -------------------          ----------
     <S>                                                 <C>                      <C>
     Capital Group International, Inc. (1)                      22,264,870               19.4%
        Capital Guardian Trust Company
     11100 Santa Monica Blvd.
     Los Angeles, California  90025

     Capital Research and Management Company (2)                 9,292,560                8.1%
     333 South Hope Street
     Los Angeles, California  90071
</TABLE>

- ---------------------

(1)      Based on a Schedule 13G filed with the Securities and Exchange
         Commission on February 14, 2000. Capital Group International, a holding
         company, reports sole dispositive power over the shares held by its
         subsidiaries. Capital Guardian Trust Company, a bank subsidiary of
         Capital Group International, reports sole voting power over 10,541,450
         shares and sole dispositive power over 13,375,100 shares. Both Capital
         Group International and Capital Guardian Trust disclaim beneficial
         ownership of the shares.
(2)      Based on a Schedule 13G filed with the Securities and Exchange
         Commission on February 14, 2000. Capital Research and Management
         Company has sole dispositive power over the shares, but does not have
         voting power over the shares and disclaims beneficial ownership of the
         shares.


                                       4
<PAGE>   7

                        PROPOSAL 1: ELECTION OF DIRECTORS

         The Company's Board of Directors is divided into three classes, as
nearly equal in number as possible. Each year the shareholders will elect the
members of one of the three classes to a three year term of office.

         The term of office of the Class III directors expires at the Annual
Meeting; the term of office of the Class I directors expires at the 2001 Annual
Meeting of Shareholders; and the term of office of the Class II directors
expires at the 2002 Annual Meeting of Shareholders, or in any event at such time
as their respective successors are duly elected and qualified or their earlier
resignation, death or removal from office.

         David F. White, Ludo J. Reynders and Rachel R. Selisker each resigned
from the Board of Directors of the Company on November 4, 1999, February 3, 2000
and February 25, 2000, respectively.

         The following table lists the directors of the Company and the classes
in which they serve as of the date of this Proxy Statement:

<TABLE>
<CAPTION>

         CLASS I                                CLASS II                                CLASS III
  (Term Expiring 2001)                   (Term Expiring 2002)                      (Term Expiring 2000)
<S>                                      <C>                                    <C>
Robert C. Bishop, Ph.D.                  Vaughn D. Bryson                       Dennis B. Gillings, Ph.D.
Santo J. Costa                           Eric J. Topol, M.D.                    Chester W. Douglass, Ph.D.
Arthur M. Pappas                         Jim D. Kever                           Virginia V. Weldon, M.D.
E.G.F. Brown                             William E. Ford                        Fred C. Goad, Jr.
</TABLE>

The Company expects that upon the completion of the sale of the Company's
wholly-owned subsidiary, ENVOY Corporation ("ENVOY"), Messrs. Kever, Ford and
Goad will resign from the Board of Directors. If this event should occur prior
to the date of the Annual Meeting of Shareholders, the vacancies created by such
resignations would not be filled by the Board of Directors prior to the Annual
Meeting. The Board of Directors may subsequently choose to fill such vacancies,
if any, during the year for a term to expire at the 2001 Annual Meeting of
Shareholders, pursuant to the Company's Bylaws.

         The Board of Directors has approved the nomination of the Class III
directors indicated above for election at the Annual Meeting to serve until the
Annual Meeting of Shareholders in the year 2003 (or until such time as their
respective successors are elected and qualified or their earlier resignation,
death or removal from office).

         The Board of Directors has no reason to believe that the persons named
above as nominees for directors will be unable or will decline to serve if
elected. However, if the completion of the sale of ENVOY should occur prior to
the date of the Annual Meeting of


                                       5
<PAGE>   8
Shareholders, the vacancy created by Mr. Goad's resignation would not be filled
by the Board of Directors prior to the Annual Meeting and a substitute nominee
will not be designated by the Board of Directors. In the event of death or
disqualification of any nominee or the refusal or inability of any nominee to
serve as a director, the proxy may be voted with discretionary authority for a
substitute or substitutes as shall be designated by the Board of Directors.

         Pursuant to North Carolina law, the four candidates who receive the
highest number of votes as Class III directors will be elected as Class III
directors of the Company. Abstentions and shares held in street name that are
not voted in the election of directors will not be included in determining which
nominees received the highest number of votes.

THE BOARD OF DIRECTORS RECOMMENDS THAT SHAREHOLDERS VOTE FOR THE ELECTION OF
THESE NOMINEES.

         Set forth below are the names and other information pertaining to the
Board's nominees and other directors whose terms of office will continue after
the Annual Meeting:

<TABLE>
<CAPTION>

                                                                                                              FIRST YEAR
                                                                                                              ELECTED
 NAME                                            POSITION WITH COMPANY                             AGE        DIRECTOR
 ----                                            ---------------------                             ---        --------

<S>                                             <C>                                               <C>            <C>
CLASS I
Robert C. Bishop, Ph.D. (1)(3)(5)               Director                                          57             1994

Santo J. Costa (5)                              Vice Chairman - Board of Directors                54             1994

Arthur M. Pappas (1)(5)(6)                      Director                                          52             1994

E.G.F. Brown (1)(2)                             Director                                          56             1998

CLASS II

Vaughn D. Bryson (1)(2)(4)                      Director                                          61             1997

Eric J. Topol, M.D. (1)(4)                      Director                                          45             1997

Jim D. Kever (4)                                Director and Chief Executive Officer of ENVOY     47             1999

William E. Ford (1)(2)                          Director                                          38             1999

Class III

Dennis B. Gillings, Ph.D. (1)                   Chairman - Board of Directors & Chief Executive   56             1982
                                                Officer

Chester W. Douglass, Ph.D. (1)(3)(4)            Director                                          60             1983

Virginia V. Weldon, M.D. (1)(3)(6)              Director                                          64             1997

Fred C. Goad, Jr. (6)                           Director                                          59             1999
</TABLE>


- -------------------------

(1)      Member of Executive Committee


                                       6

<PAGE>   9

(2)      Member of Audit Committee
(3)      Member of Compensation Committee
(4)      Member of Quality Committee
(5)      Member of Nominations Committee
(6)      Member of Human Resources Committee

         ROBERT C. BISHOP, PH.D. has served as a director since April 1994.
Since June 1999, Dr. Bishop has served as Chairman of the Board for AutoImmune,
Inc., a biotechnology company. From May 1992 to December 1999, Dr. Bishop served
as President, Chief Executive Officer and director of AutoImmune, Inc. From
February 1991 to April 1992, Dr. Bishop served as President of Allergan
Therapeutics Group, a division of Allergan, Inc., an eye and skin care company.
From August 1989 to February 1991, Dr. Bishop served as President of Allergan
Pharmaceuticals, a division of Allergan, Inc. Dr. Bishop serves as a director of
Millipore Corporation, a multinational company that applies its purification
technology to research and manufacturing applications in the microelectronics
and biopharmaceutical industries. Dr. Bishop received an M.B.A. from the
University of Miami and a Ph.D. in Biochemistry from the University of Southern
California.

         E. G. F. BROWN has served as a director since January 1998. Mr. Brown
is Chairman - Mainland Europe of Tibbett & Britten Group plc. Mr. Brown was
previously an Executive Director of T.D.G. PLC, a European logistics company,
and a director of Datrontech PLC, a distributor of personal computer components.
Prior to joining TDG in 1996, Mr. Brown served as Operations Director for NFC
PLC, a supply chain logistics company. Mr. Brown was educated at Exeter and
Reading Universities and the London Business School.

         VAUGHN D. BRYSON has served as a director since March 1997. Mr. Bryson
is President of Life Science Advisors, LLC, a consulting firm focused on
assisting biopharmaceutical and medical device firms in building shareholder
value. Mr. Bryson was a 32 year employee of Eli Lilly & Co. ("Lilly"), a global
research-based pharmaceutical corporation, where he served as President and
Chief Executive Officer from 1991 until June 1993; he was Executive Vice
President from 1986 until 1991. He served as a director of Lilly from 1984 until
his retirement in 1993. From April 1994 to December 1996, Mr. Bryson served as
Vice Chairman of Vector Securities International, Inc., an investment banking
firm. Mr. Bryson is a director of Ariad Pharmaceuticals, Inc., a developer of
pharmaceuticals that targets intracellular signaling pathways in order to alter
the course of disease; Chiron Corporation, a global healthcare company with
biopharmaceutical businesses; Fusion Medical Technologies, Inc., a company
developing and commercializing proprietary collagen gel-based products for use
in controlling bleeding during surgery; and Amylin Pharmaceuticals, Inc., a
developmental stage biopharmaceutical company focusing on metabolic disorders.

         SANTO J. COSTA became Vice Chairman in November 1999 and has been a
director since April 1994. Mr. Costa served as the Company's President and Chief
Operating Officer from April 1994 to November 1999. From July 1993 to March
1994, Mr. Costa directed the affairs of his own consulting firm, Santo J. Costa
& Associates, which focused on pharmaceutical and biotechnology companies. Prior
to July 1993, Mr. Costa served seven years at Glaxo, Inc., a


                                       7
<PAGE>   10

pharmaceutical company, as Senior Vice President Administration and General
Counsel and a member of the Board of Directors. Mr. Costa serves as a director
of NPS Pharmaceuticals Inc., a pharmaceutical company engaged in the discovery
and development of small molecule drugs that address a variety of diseases. Mr.
Costa received a law degree from St. John's University.

         CHESTER W. DOUGLASS, PH.D. has served as a director since 1983. Dr.
Douglass is Professor and Chairman of the Department of Oral Health Policy and
Epidemiology, Harvard University School of Dental Medicine and Professor,
Department of Epidemiology, Harvard University School of Public Health. Dr.
Douglass has served over 30 years in various academic appointments at Temple
University, the University of North Carolina at Chapel Hill and Harvard
University. Dr. Douglass received a D.M.D. from the Temple University School of
Dentistry, an M.P.H. from the University of Michigan School of Public Health and
a Ph.D. from the University of Michigan Rackham School of Graduate Studies.

         WILLIAM E. FORD has served as a director since June 1999. He was
appointed a director of ENVOY in March 1996 and served as a director until the
Company acquired ENVOY in March 1999. Mr. Ford has served as a managing member
of General Atlantic Partners LLC, a private equity firm that invests globally in
information technology companies, since 1991. Mr. Ford is also a director of
Priceline.com Incorporated, a publicly traded buyer-driven e-commerce company
whose "demand collection system" enables consumers to use the Internet to save
money on a wide range of products and services; E*Trade Group, Inc., a provider
of online investing services for self-directed investors; Tickets.com, a
provider of entertainment tickets, event information and related products and
services through retail stores, telephone sales centers, interactive voice
response systems and the Internet; LHS Group, Inc., a publicly-traded billing
solutions software company; Eclipsys Corporation, a provider of clinical,
financial and administrative software solutions to the health care industry and
several private software companies in which General Atlantic Partners, LLC or
one of its affiliates is an investor.

         FRED C. GOAD, JR. has served as a director since June 1999. He served
as the Chairman and Co-Chief Executive Officer of ENVOY from August 1995 until
the Company acquired ENVOY in March 1999, and as a director from ENVOY's
incorporation in August 1994 through March 1999. Prior to that time, he served
as ENVOY's President from the date of incorporation until assuming the title of
Chairman and Co-Chief Executive Officer in August 1995. Mr. Goad served as Chief
Executive Officer and a director of ENVOY Corporation, a Delaware corporation
and former parent corporation to ENVOY, from September 1985 through June 1995.
Mr. Goad is a director of Performance Food Group Company, a food distribution
company.

         DENNIS B. GILLINGS, PH.D. founded Quintiles in 1982 and has served as
Chief Executive Officer and Chairman of the Board of Directors since its
inception. From 1972 to 1988, Dr. Gillings served as a professor in the
Department of Biostatistics at the University of North Carolina at Chapel Hill.
During his tenure as a professor, he was active in statistical consulting for
the pharmaceutical industry. Dr. Gillings currently serves on the Dean's
Advisory Council of the University of North Carolina School of Public Health.
Dr. Gillings has been published widely in scientific and medical journals. Dr.
Gillings serves as a director of Triangle Pharmaceuticals, Inc., a company
engaged in the development of new drug candidates primarily


                                       8
<PAGE>   11
in the antiviral area. Dr. Gillings received a Diploma in Mathematical
Statistics from the University of Cambridge and a Ph.D. in Mathematics from the
University of Exeter.

         JIM D. KEVER has served as a director since June 1999. He has served as
Chief Executive Officer of ENVOY, since the Company acquired ENVOY in March
1999. Mr. Kever served as President and Co-Chief Executive Officer of ENVOY from
August 1995 until March 1999 and as a director from ENVOY's incorporation in
August 1994 until March 1999. Prior to such time, he served as ENVOY's Executive
Vice President, Secretary and General Counsel from the date of incorporation.
Mr. Kever had served as a director and Secretary, Treasurer and General Counsel
of ENVOY's former parent corporation since 1981 and as Executive Vice President
since 1984. Mr. Kever also is a director of Transaction System Architects, Inc.,
a supplier of electronic payment software products and network integration
solutions, 3D Systems Corporation, a manufacturer of technologically advanced
solid imaging systems and prototype models, and Tyson Foods, where he also
serves on the audit and ethics committees.

         ARTHUR M. PAPPAS has served as a director since September 1994. Mr.
Pappas is Chairman and Chief Executive Officer of A. M. Pappas & Associates,
LLC, an international consulting, investment and venture company that works with
life science companies, products and related technologies. Prior to founding A.
M. Pappas & Associates in 1994, Mr. Pappas was a director on the main board of
Glaxo Holdings plc with executive responsibilities for operations in Asia
Pacific, Latin America, and Canada. In this capacity, he served as Chairman and
Chief Executive of Glaxo Far East (Pte) Ltd. and Glaxo Latin America Inc., as
well as Chairman of Glaxo Canada Inc. Mr. Pappas has held various senior
executive positions with Abbott Laboratories International Ltd., Merrell Dow
Pharmaceuticals, and the Dow Chemical Company, in the United States and
internationally. Mr. Pappas is a director of Valentis Inc., a gene therapy
research company; Embrex Inc., a research and development company specializing
in poultry in-the-egg delivery systems; and KeraVision, Inc., a company
developing products for reversible vision correction surgery. He is also a
director of privately-held AtheroGenics Inc. and ArgoMed, Inc. Mr. Pappas
received a B.S. in biology from Ohio State University and an M.B.A. in finance
from Xavier University.

         ERIC J. TOPOL, M.D. has served as a director since November 1997. Dr.
Topol is the Chairman of the Department of Cardiology and co-director of the
Heart Center at The Cleveland Clinic Foundation. He has served as Study Chairman
for clinical trials of well over 100,000 patients over the past decade. Dr.
Topol was a faculty member of the University of Michigan from 1985 until 1991
before moving to his current post. He has authored more than 500 publications in
leading peer-review medical journals and is the editor of more than 10 books.
Dr. Topol has been elected to the American Society of Clinical Investigation and
the American Association of Physicians. He previously served as a director for
Rhone Poulenc Rorer, a leading life sciences company, specializing in
innovations in human, plant and animal health. Dr. Topol received his M.D. at
the University of Rochester and completed post-doctoral training at the
University of California, San Francisco and the Johns Hopkins Medical Center.


                                       9
<PAGE>   12

         VIRGINIA V. WELDON, M.D. has served as a director since November 1997.
Dr. Weldon served as Senior Vice President, Public Policy, Monsanto Company, an
agro-chemicals and biotechnology (life sciences) company, from October 1993
until her retirement in March 1998. Previously, she was Professor of Pediatrics,
Vice Chancellor for Medical Affairs and Vice President of the Medical Center at
Washington University in St. Louis. Dr. Weldon has received recognition from
numerous medical, scientific and educational organizations, among them the
Association of American Medical Colleges, of which she served as Chairman. In
1994, Dr. Weldon was one of 18 individuals appointed to the President's
Committee of Advisors on Science and Technology. More recently, she became a
member of the California Institute of Technology Board of Trustees. Dr. Weldon
received her medical degree from the State University of New York at Buffalo.
She also completed post-doctoral studies at the Johns Hopkins University.

BOARD OF DIRECTORS MEETINGS AND COMMITTEES

         The Board of Directors met 10 times during 1999. The Board has an
Executive Committee, Audit Committee, Compensation Committee, Quality Committee,
Nominations Committee, and Human Resources Committee. The Board also had a
Policy Committee, which was combined with the Quality Committee in May 1999. The
Executive Committee has the authority to exercise all powers of the Board of
Directors during intervals between meetings of the Board. The Executive
Committee met four times during 1999. The Audit Committee reviews the results
and scope of the audit and other services provided by the Company's independent
public accountants. The Audit Committee also recommends to the Board the
appointment of independent public accountants. The Audit Committee met four
times during 1999. The Compensation Committee is responsible for the approval of
compensation arrangements for officers of the Company and the review of the
Company's compensation plans and policies. The Compensation Committee met four
times during 1999. The Quality Committee oversees the reporting of serious
adverse events for the Company's studies, establishes policies regarding
scientific integrity and quality assurance and has taken over the
responsibilities of the Policy Committee. During 1999, the Quality Committee met
five times. The Policy Committee was responsible for reviewing conflicts of
interest arising from the provision of services to a wide variety of clients and
overseeing the conflicts resolution process. The Policy Committee met two times
during 1999. The Nominations Committee nominates individuals to serve on the
Board of Directors for shareholder approval or, in the case of filling a
vacancy, for Board approval. The Nominations Committee met three times during
1999. The Human Resources Committee oversees strategic global human resources
issues. During 1999, the Human Resources Committee met four times.

         The Company's Bylaws provide procedures for the nomination of
directors. The Bylaws provide that nominations for the election of directors may
only be made by the Board of Directors or a designated committee thereof, or by
any shareholder entitled to vote generally in elections of directors if the
shareholder follows certain procedures. Any shareholder of record entitled to
vote generally in the election of directors may nominate one or more persons for
election as directors at a meeting of shareholders only if written notice of
such shareholder's intent to make such nomination or nominations has been given,
either by personal delivery or


                                       10
<PAGE>   13
certified mail, postage prepaid, to the Secretary of the Company (i) with
respect to an election to be held at an annual meeting of shareholders, not more
than ninety (90) days nor less than fifty (50) days in advance of such meeting;
and (ii) with respect to an election to be held at a special meeting of
shareholders called for the purpose of the election of directors, not later than
the close of business on the tenth business day following the date on which
notice of such meeting is first given to shareholders. Each such notice of a
shareholder's intent to nominate a director must set forth certain information
as specified in the Company's Bylaws.

         Each director attended 75% or more of the aggregate of the Board
meetings (held during the period for which the director was in office) and
committee meetings of the Board of which the director was a member; except for
Mr. Ford who attended 71% of the aggregate meetings of the Board and Dr. Topol
who attended 60% of the aggregate meetings of the Quality Committee of which he
was a member.

DIRECTOR COMPENSATION

         Each non-officer director receives annually a grant of stock options
valued at $100,000 with the number of options determined in accordance with the
Black-Scholes method. In addition, each non-officer director receives (1) an
annual retainer of $24,000, (2) $1,000 for each Board meeting attended in person
or by teleconference and (3) $500 for each committee meeting attended in person
or by teleconference, each paid quarterly in cash. Beginning in 2000, committee
chairs will also receive an extra $5,000 per year in compensation for their
additional responsibilities. The Company reimburses each director for
out-of-pocket expenses incurred in connection with the rendering of services as
a director. Certain other financial relationships with directors are described
in "Certain Relationships and Related Transactions."

         EXECUTIVE OFFICERS

         Set forth below is certain information with respect to each of the
Company's executive officers who are not directors.

<TABLE>
<CAPTION>
NAME                                 AGE    POSITION WITH THE COMPANY
- ----                                 ---    -------------------------
<S>                                   <C>   <C>
James L. Bierman                      47    Chief Financial Officer

John S. Russell                       45    Senior Vice President and General Counsel,
                                            Head Global Human Resources
</TABLE>

         JAMES L. BIERMAN became Chief Financial Officer in February 2000 and
served as the Company's Senior Vice President, Corporate Development since 1998.
Previously, Mr. Bierman spent 22 years with Arthur Andersen LLP. As a partner of
this international professional services organization, he worked with a
diversified broad-base of companies solving complex business problems. His
experience ranges from applying knowledge of complex business processes to
improve operational efficiency and effectiveness while reducing risk to
researching and developing leading-edge accounting issues. He has been a
frequent speaker at various industry


                                       11
<PAGE>   14
trade group-sponsored symposiums on various financial and accounting topics. He
has authored several articles, the latest of which was published in Bank
Director White Paper Mergers and Acquisitions: Strategies and Trends Shaping the
Industry. The article is titled "Mergers of Equals vs. Acquisition: Strategies
for Success." Mr. Bierman received his B.A. degree in Economics/History from
Dickinson College in Carlisle, Pennsylvania, and attended Cornell University's
Johnson Graduate School of Management, where he received his M.B.A.

         JOHN S. RUSSELL serves as Senior Vice President and General Counsel and
Head of Global Human Resources. He is also the Corporate Secretary. Mr. Russell
joined the Company in 1998 after 12 years in private practice as a partner in
the Raleigh office of the Moore and Van Allen law firm, where he was head of the
Corporate Practice group. Prior to that time, he was an editor in the trade
books division of Houghton Mifflin Company in New York City. Mr. Russell has
served as Director of the North Carolina Railroad Company as well as several
nonprofit concerns. He has spoken and published widely on legal and literary
topics. His novel, Favorite Sons, was published by Algonquin Books in 1992. Mr.
Russell received a B.A. degree from the University of North Carolina at Chapel
Hill, his M.A. from Columbia University and a J.D. degree from Harvard Law
School.


                                       12
<PAGE>   15


                             EXECUTIVE COMPENSATION

         The following tables show annual and long-term compensation paid or
accrued by the Company for services rendered for the fiscal years indicated by
the Company's Chief Executive Officer and the next four most highly compensated
executive officers (the "named executive officers") whose total salary and bonus
exceeded $100,000 individually during the year ended December 31, 1999.

<TABLE>
<CAPTION>
                                            SUMMARY COMPENSATION TABLE

                                                                                          Long Term
                                            Annual Compensation                         Compensation
                               ------------------------------------------------------    -------------
                                                                                           No. Of
                                                                                         Securities             All
          Name and                                                       Other Annual    Underlying           Other
     Principal Position        Year          Salary          Bonus       Compensation      Options         Compensation
     ------------------        ----          ------          -----       ------------      -------         ------------

<S>                            <C>          <C>            <C>           <C>             <C>              <C>
Dennis B. Gillings             1999         $568,749(1)    $     --      $        (2)     169,316(3)       $  472,070(4)
    Chairman of the Board of   1998          474,996(5)          --               (2)      25,048(6)          349,236(7)
    Directors and Chief        1997          447,400(8)          --               --       24,013(9)          231,009(10)
    Executive Officer

Santo J. Costa                 1999         $474,453       $     --      $        (2)     201,650(11)      $    5,853(12)
    Vice Chairman              1998          450,000             --               (2)      22,553(13)         760,552(14)
                               1997          425,000             --         43,981(15)    119,338(16)       2,336,090(17)

Ludo J. Reynders               1999         $341,253       $     --      $        (2)      46,521(18)      $    4,566(19)
    Chief Executive Officer,   1998          315,000             --               (2)      23,803(20)           6,837(21)
    Clinical Development       1997          301,415             --               (2)      64,477(22)          11,781(23)
    Services

Rachel R. Selisker             1999         $265,125       $     --      $        (2)      55,385(24)      $    5,626(25)
    Senior Consultant,         1998          237,000             --               (2)      12,771(26)           9,225(27)
    Global Shared Services     1997          225,000             --               (2)      34,378(28)          17,620(29)

Jim D. Kever                   1999(30)     $196,500       $178,500(31)  $        (2)     127,871(32)      $    4,053(33)
    Chief Executive Officer,
    ENVOY
</TABLE>

- -------------------
(1)      Includes $284,375 deferred during 1999 pursuant to the Company's
         Elective Deferred Compensation Plan.
(2)      Perquisites and other personal benefits received did not exceed the
         lesser of $50,000 or 10% of salary and bonus compensation for the named
         executive officer.
(3)      Includes 12,792 shares subject to options granted pursuant to the 1999
         bonus.
(4)      Includes contributions to the Company's 401(k) Plan on behalf of Dr.
         Gillings in the amount of $2,375, the estimated value of contributions
         made to the ESOP on Dr. Gillings' behalf in the amount of $1,038, the
         present value of the benefit to Dr. Gillings of the premiums the
         Company paid under a split-dollar life insurance arrangement in the
         amount of $463,583 (see "Employment Agreements" below for a description
         of this arrangement), and other life insurance premiums that the
         Company paid in the amount of $5,074. In 1999, with the use of his own
         plane, Dr. Gillings provided extensive business-related travel services
         for himself and other Company employees. The Compensation Committee
         approved reimbursing Dr. Gillings for these services by making a cash


                                       13
<PAGE>   16


         payment of $1.4 million, which was estimated to be significantly less
         than the cost of operating the plane for Company business purposes.
         This payment is not included in this table. The Company also granted
         options to Dr. Gillings with a Black-Scholes value of $1.4 million at
         an exercise price of $42.44. These options are included in the table as
         long term compensation.
(5)      Includes $236,348 deferred during 1998 pursuant to the Company's
         Elective Deferred Compensation Plan.
(6)      Includes 6,053 shares subject to options granted pursuant to the 1998
         bonus.
(7)      Includes contributions to the Company's 401(k) Plan on behalf of Dr.
         Gillings in the amount of $2,364, the estimated value of contributions
         made to the ESOP on Dr. Gillings' behalf in the amount of $6,031, the
         present value of the benefit to Dr. Gillings of the premiums the
         Company paid under a split-dollar life insurance arrangement in the
         amount of $335,686 (see "Employment Agreements" below for a description
         of this arrangement), and other life insurance premiums that the
         Company paid in the amount of $5,155.
(8)      Includes $55,925 deferred during 1997 pursuant to the Company's
         Elective Deferred Compensation Plan.
(9)      Includes 7,042 shares subject to options granted pursuant to the 1997
         bonus.
(10)     Includes contributions to the Company's 401(k) Plan on behalf of Dr.
         Gillings in the amount of $2,237, the value of contributions made to
         the ESOP on Dr. Gillings' behalf in the amount of $16,473, the present
         value of the benefit to Dr. Gillings of the premiums that the Company
         paid under a split-dollar life insurance arrangement in the amount of
         $207,144 (see "Employment Agreements" below for a description of this
         arrangement), and other life insurance premiums that the Company paid
         in the amount of $5,155.
(11)     Includes 9,443 shares subject to options granted pursuant to the 1999
         bonus.
(12)     Includes $1,038, which represents the estimated value of contributions
         made to the ESOP on behalf of Mr. Costa. Also includes $4,815
         representing the value of life insurance premiums paid in 1999.
(13)     Includes 5,299 shares subject to options granted pursuant to the 1998
         bonus.
(14)     Includes $749,625, which represents the appreciation of incentive stock
         options exercised, and $6,031, which represents the estimated value of
         the contributions made to the ESOP on behalf of Mr. Costa. Also
         includes $4,896 representing the value of life insurance premiums paid
         in 1998.
(15)     Amount represents the value of financial planning and legal costs that
         the Company paid on behalf of Mr. Costa.
(16)     Includes 5,549 shares subject to options granted pursuant to the 1997
         bonus.
(17)     Includes $2,317,260, which represents the appreciation of incentive
         stock options exercised, and $14,510 which represents the estimated
         value of the contributions made to the ESOP on behalf of Mr. Costa.
         Also includes $4,320 representing the value of life insurance premiums
         paid in 1997.
(18)     Includes 5,259 shares subject to options granted pursuant to the 1999
         bonus.
(19)     Includes $2,375 in contributions to the Company's 401(k) Plan on behalf
         of Mr. Reynders, life insurance premiums that the Company paid in the
         amount of $1,153 and $1,038 representing the estimated value of
         contributions made to the ESOP on behalf of Mr. Reynders.




                                       14
<PAGE>   17


(20)     Includes 3,514 shares subject to options granted pursuant to the 1998
         bonus.
(21)     Includes $806 in contributions to the Company's 401(k) Plan on behalf
         of Mr. Reynders and $6,031 representing the estimated value of
         contributions made to the ESOP on behalf of Mr. Reynders.
(22)     Includes 2,810 shares subject to options granted pursuant to the 1997
         bonus.
(23)     Amount represents the value of contributions to the Quintiles (UK)
         Limited Approved Profit Sharing Scheme on behalf of Dr. Reynders.
(24)     Includes 4,123 shares subject to options granted pursuant to the 1999
         bonus.
(25)     Includes $2,604 in contributions to the Company's 401(k) Plan on behalf
         of Ms. Selisker, life insurance premiums that the Company paid in the
         amount of $896 and $1,038 representing the estimated value of
         contributions made to the ESOP on behalf of Ms. Selisker.
(26)     Includes 2,482 shares subject to options granted pursuant to the 1998
         bonus.
(27)     Includes contributions to the Company's 401(k) Plan on behalf of Ms.
         Selisker in the amount of $2,430, the estimated value of contributions
         made to the ESOP on Ms. Selisker's behalf in the amount of $5,931 and
         life insurance premiums that the Company paid in the amount of $864.
(28)     Includes 2,711 shares subject to options granted pursuant to the 1997
         bonus.
(29)     Includes $2,400 in contributions to the Company's 401(k) Plan on behalf
         of Ms. Selisker, life insurance premiums that the Company paid in the
         amount of $691 and $14,529 representing the estimated value of
         contributions made to the ESOP on behalf of Ms. Selisker.
(30)     Mr. Kever is Chief Executive Officer of ENVOY, which became the
         Company's wholly-owned subsidiary following the Company's acquisition
         of ENVOY in March 1999. After completion of the Company's pending
         agreement to sell ENVOY, Mr. Kever will no longer be one of the
         Company's executive officers.
(31)     Amount represents payments made in 2000 pursuant to Mr. Kever's current
         employment contract with ENVOY.
(32)     Includes 64,271 shares subject to options granted pursuant to the 1999
         bonus.
(33)     Includes $1,875 representing the value of contributions made to the
         Company's 401(k) Plan on behalf of Mr. Kever in 1999 and $2,345 which
         represents the value of life insurance premiums paid for Mr. Kever in
         1999.

                        OPTION GRANTS IN LAST FISCAL YEAR

         The following table reflects the stock options granted during the past
fiscal year to the named executive officers pursuant to the Company's Equity
Compensation Plan and Nonqualified Stock Option Plan. No stock appreciation
rights were granted to the named executive officers during 1999. Unless
otherwise noted, all options expire 10 years from the date of grant or, if
sooner, three months after termination of employment, unless employment is
terminated because of (1) death or disability in which case the options expire
one year after the date of such termination, (2) retirement as determined by the
administrator of the Plan, in which case the options expire ten years after such
termination, if the holder has agreed to a non-compete; otherwise, the options
expire one year after such termination or (3) termination as a


                                       15
<PAGE>   18



result of a Special Program, as determined by the administrator of the Plan, in
which case the options expire three years after the date of such termination.

<TABLE>
<CAPTION>
                                                                                         POTENTIAL REALIZABLE VALUE
                                                                                            AT ASSUMED ANNUAL RATES
                                                                                               OF STOCK PRICE
                                                                                          APPRECIATION FOR OPTION
                                               INDIVIDUAL GRANTS                                   TERM (1)
                          ------------------------------------------------------------    -------------------------
                            NUMBER OF      PERCENT OF
                            SECURITIES   TOTAL OPTIONS
                           UNDERLYING      GRANTED TO      EXERCISE OR
                             OPTIONS      EMPLOYEES IN     BASE PRICE       EXPIRATION
         NAME                GRANTED    FISCAL YEAR (2)   PER SHARE ($)         DATE      5% ($)          10% ($)
         ----             -----------   ---------------   -------------     -----------  -----------    ----------
<S>                       <C>           <C>               <C>               <C>          <C>            <C>
Dennis B. Gillings          2,356  (3)       0.0%              42.44        06/07/2009      62,879         159,347
                           21,470  (4)       0.2%              42.44        06/07/2009     573,007       1,452,112
                            3,664  (5)       0.0%              42.44        06/07/2009      97,787         247,813
                            5,940  (6)       0.1%              35.88        08/15/2009     134,015         339,623
                           33,630  (7)       0.4%              35.88        08/15/2009     758,746       1,922,812
                            3,188  (8)       0.0%              22.00        11/15/2009      44,108         111,779
                           45,697  (9)       0.5%              22.00        11/15/2009     632,249       1,602,243
                           53,371 (10)       0.6%              42.44        06/07/2009   1,424,403       3,609,718

Santo J. Costa              2,356  (3)       0.0%              42.44        06/07/2009      62,879         159,347
                           14,322 (11)       0.2%              42.44        06/07/2009     382,236         968,661
                            2,874  (5)       0.0%              42.44        06/07/2009      76,703         194,381
                            4,003  (6)       0.0%              35.88        08/15/2009      90,314         228,874
                           23,541  (7)       0.3%              35.88        08/15/2009     531,123       1,345,969
                            2,566  (8)       0.0%              22.00        11/15/2009      35,502          89,970
                           31,988  (9)       0.4%              22.00        11/15/2009     442,576       1,121,574
                           90,000 (10)       1.0%              42.44        06/07/2009   2,401,984       6,087,100
                           30,000 (12)       0.3%              40.19        03/14/2009     758,211       1,921,456

Ludo J. Reynders            2,356  (3)       0.0%              42.44        06/07/2009      62,879         159,347
                            7,175 (13)       0.1%              42.44        06/07/2009     191,492         485,277
                            1,700  (5)       0.0%              42.44        06/07/2009      45,371         114,979
                            2,228  (6)       0.0%              35.88        08/15/2009      50,267         127,387
                           13,452  (7)       0.1%              35.88        08/15/2009     303,499         769,125
                            1,331  (8)       0.0%              22.00        11/15/2009      18,415          46,668
                           18,297  (9)       0.2%              22.00        11/15/2009     252,902         640,904

Rachel R. Selisker          2,356  (3)       0.0%              42.44        06/07/2009      62,879         159,347
                            7,175 (13)       0.1%              42.44        06/07/2009     191,492         485,277
                            1,189  (5)       0.0%              42.44        06/07/2009      31,733          80,417
                            1,788  (6)       0.0%              35.88        08/15/2009      40,295         102,115
                           13,452  (7)       0.1%              35.88        08/15/2009     303,499         769,125
                            1,148  (8)       0.0%              22.00        11/15/2009      15,883          40,252
                           18,279  (9)       0.2%              22.00        11/15/2009     252,902         640,904
                           10,000 (14)       0.1%              50.88        02/04/2009     319,950         810,816

Jim D. Kever               64,271 (15)       0.7%              18.69        12/31/2009     755,343       1,914,187
                           63,600 (16)       0.7%              18.94        11/05/2009     757,456       1,919,543
</TABLE>

- --------------

(1)      Potential realizable value of each grant is calculated assuming that
         market price of the underlying security appreciates at annualized rates
         of 5% and 10%, respectively, over the


                                       16
<PAGE>   19


         10 year term of the grant. The assumed annual rates of appreciation of
         5% and 10% would result in the price of the Common Stock increasing to
         $82.87 and $131.96 per share, respectively, for the options expiring
         February 4, 2009, $69.13 and $110.07 per share, respectively, for the
         options expiring June 7, 2009, $58.44 and $93.05 per share,
         respectively, for the options expiring August 15, 2009, $35.84 and
         $57.06 per share, respectively, for the options expiring November 15,
         2009, $30.85 and $49.12 per share, respectively, for the options
         expiring November 5, 2009, $65.46, and $104.24 per share, respectively,
         for the options expiring March 14, 2009, and $30.44 and $48.47 per
         share, respectively, for the options expiring December 31, 2009.
(2)      Options to purchase an aggregate of 9,095,779 shares were granted to
         employees during 1999.
(3)      Incentive stock options granted June 7, 1999. Number of options granted
         as incentive stock options to extent of annual $100,000 cap; options in
         excess of the cap granted as nonqualified options. Shares subject to
         the options granted vest June 7, 2003.
(4)      Nonqualified stock options granted June 7, 1999. Shares subject to the
         options granted vest over the next four years, with 28% of such shares
         vesting on June 7 of each of 2000, 2001 and 2002 and 16% vesting on
         June 7, 2003.
(5)      Nonqualified stock options granted June 7, 1999. Shares subject to the
         options granted vest on May 15, 2000.
(6)      Nonqualified stock options granted August 15, 1999. Shares subject to
         the options granted vest on May 15, 2000.
(7)      Nonqualified stock options granted August 15, 1999. Shares subject to
         the options granted vest over the next four years, with 25% of such
         shares vesting on August 15 of each year beginning August 15, 2000.
(8)      Nonqualified stock options granted November 15, 1999. Shares subject to
         the options granted vested on May 15, 2000.
(9)      Nonqualified stock options granted November 15, 1999. Shares subject to
         the options granted vest over the next four years, with 25% of such
         shares vesting on November 15 of each year beginning November 15, 2000.
(10)     Nonqualified stock options granted June 7, 1999. Shares subject to the
         options granted vested immediately.
(11)     Nonqualified stock options granted June 7, 1999. Shares subject to the
         options vest over the next four years with 29% of such shares vesting
         on June 7 of each of 2000, 2001 and 2002 and 13% vesting on June 7,
         2003.
(12)     Nonqualified stock options granted March 14, 1999. Shares subject to
         the options granted vested immediately.
(13)     Nonqualified stock options granted June 7, 1999. Shares subject to the
         options vest over the next four years with 33% of such shares vesting
         on June 7 of each of 2000, 2001 and 2002 and 1% vesting on June 7,
         2003.
(14)     Nonqualified stock options granted February 4, 1999. Shares subject to
         the options granted vest over two years, with 50% of such shares
         vesting on December 31 of each year beginning December 31, 1999.
(15)     Nonqualified stock options granted December 31, 1999. Shares subject to
         the options granted vest over the next four years, with 25% of such
         shares vesting on December 31 of each year beginning December 31, 2000.
         In connection with the Company's sale of


                                       17
<PAGE>   20


         ENVOY, Mr. Kever will participate in a Special Program, which means
         that the shares subject to these options vest immediately upon, and the
         options expire three years from, the date of the Company's sale of
         ENVOY.
(16)     Nonqualified stock options granted November 5, 1999. Shares subject to
         the options granted vest over the next two years, with 50% of such
         shares vesting on November 5 of each year beginning November 5, 2000.
         In connection with the Company's sale of ENVOY, Mr. Kever will
         participate in a Special Program, which means that the shares subject
         to these options vest immediately upon, and the options expire three
         years from, the date of the Company's sale of ENVOY.

                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                        AND FISCAL YEAR END OPTION VALUES

The following table provides information about the stock options held by the
named executive officers on December 31, 1999.

<TABLE>
<CAPTION>
                                                              NUMBER OF SECURITIES          VALUE OF UNEXERCISED IN-THE
                        SHARES ACQUIRED       VALUE          UNDERLYING UNEXERCISED                 MONEY OPTIONS
         NAME           ON EXERCISE(#)      REALIZED ($)        OPTIONS AT FY-END                   AT FY-END (1)
         ----           --------------     ------------    ---------------------------     --------------------------------

                                                           EXERCISABLE   UNEXERCISABLE     EXERCISABLE($)  UNEXERCISABLE($)
                                                           -----------   -------------     --------------  ----------------
<S>                     <C>                <C>             <C>           <C>               <C>             <C>
Dennis B. Gillings            --               --             183,370        143,051           775,835           --
Santo J. Costa                --               --             280,493        107,072           107,198           --
Ludo J. Reynders              --               --             112,971         70,070           315,602           --
Rachel R. Selisker            --               --              81,005         67,377           364,032           --
Jim D. Kever                  --               --             635,470        139,486         6,474,078           --
</TABLE>

- ----------------------

 (1)     The value of the options is based upon the difference between the
         exercise price and the closing price per share on December 31, 1999,
         $18.6875.

                          COMPENSATION COMMITTEE REPORT

         The Compensation Committee of the Board of Directors reviews and
oversees the general compensation plans and policies of the Company and approves
the individual compensation arrangements for the Company's executive officers.

EXECUTIVE COMPENSATION PHILOSOPHY

         The Company is committed to implementing a scheme of executive
compensation which will contribute to the achievement of the Company's business
objectives. Based on a study of the Company's executive compensation policies
and procedures by a nationally recognized consulting firm, the Company has an
executive compensation program which it believes:

         -        Fulfills the Company's business and operating needs, comports
                  with its general human resource strategies and enhances
                  shareholder value.


                                       18
<PAGE>   21


         -        Enables the Company to attract and retain the executive talent
                  essential to the Company's achievement of its business
                  objectives.

         -        Rewards executives for accomplishment of pre-defined business
                  goals and objectives.

         -        Provides rewards consistent with gains in shareholder wealth
                  so that executives will be financially advantaged when
                  shareholders are similarly financially advantaged.

         -        Reflects the evolving organizational structure of the Company,
                  directly motivates executives to accomplish results within
                  their range of influence and fosters team spirit among
                  executives working towards a common goal.

         In implementing its compensation philosophy, the Company intends to
provide compensation opportunities which are perceived to be generally
comparable to those provided by similar companies in the contract research
organization, biotechnology and pharmaceutical industries. This "peer group" is
not the same group used for the industry comparison in the performance graph
found in the "Comparison of Cumulative Return" section of this Proxy Statement;
rather, it reflects the industry groups with which the Company competes for
personnel.

ELEMENTS OF EXECUTIVE COMPENSATION

         The Company's executive compensation program has four key components:
base salary, quarterly performance awards, long-term incentive awards and
benefits. Performance awards and long-term incentive awards are granted pursuant
to the Company's executive compensation plan. These components combine fixed and
variable elements to create a total compensation package which provides some
income predictability while linking a significant portion of compensation to
corporate, business unit and individual performance.

BASE SALARY

         Salary represents the fixed component of the Company's executive
compensation program. Base salaries are set within ranges which are targeted
around the competitive norm for similar companies in the contract research
organization, biotechnology and pharmaceutical industries. Individual salaries
may be above or below the competitive norm, depending on the executive's tenure
in his position and performance. The Compensation Committee considers the
following factors in approving adjustments to salary levels for the executive
officers: (i) the relationship between current salary and appropriate internal
and external salary comparisons, (ii) the average size of salary increases being
granted by competitors, (iii) whether the responsibilities of the position have
changed during the preceding year and (iv) the individual's performance as
reflected in the overall manner in which his assigned role is carried out.


                                       19
<PAGE>   22



QUARTERLY PERFORMANCE AWARDS

         Quarterly performance awards serve two functions in implementing the
Company's executive compensation philosophy. First, quarterly incentives permit
the Company to compensate officers directly for performance as measured by
objective standards. Second, quarterly incentives also serve to focus executives
on those activities that are most directly under their control and for which
they should be held accountable.

         Each year, the Company establishes target performance award
opportunities (expressed as a percentage of salary), which participants can
expect to earn if all performance goals are fully achieved during the next
fiscal year. Performance awards are proportionately increased or decreased from
the target to reflect performance levels that exceed or fall below expectations.

         At the beginning of each year, specific performance goals are set for
the Company and, each business unit and individual participant. For 1999, the
Company determined that the best criteria for measurement of Company and
business unit performance were operating surplus and net revenue, weighted at
60% and 40%, respectively. Individual performance goals are assigned annually
relating to quality, productivity, expense control, innovation, personal
management, etc. Individual performance is also assessed by subjective
evaluation.

         Performance awards are linked to specific performance goals established
by the Company. The executive compensation plan gives the Company's Compensation
Committee the authority to award performance awards or reduce or entirely
eliminate the performance awards. Performance awards may be made in cash, stock,
stock options or a combination of each. Generally, the Compensation Committee
awards cash awards to executive officers only to the extent operating surplus
for the Company as a whole is in excess of target levels. In 1999, executive
officer performance awards primarily were awarded in the form of nonqualified
stock options, as described below.

         Relative to their performance during 1999, the Company issued
non-qualified stock options to executive officers on a quarterly basis. Stock
options were granted on June 7, 1999, August 15, 1999, November 15, 1999 and
February 15, 2000, for the calendar quarters of 1999. The following table
provides the number of option shares granted per quarter to each of the
executive officers, other than Mr. Kever, along with the exercise price per
share, which is equal to the closing price of the Company's Common Stock on date
of grant and the corresponding Black-Scholes value.


                                       20
<PAGE>   23




<TABLE>
<CAPTION>
                                 JUNE 7, 1999         AUGUST 15, 1999        NOVEMBER 15, 1999      FEBRUARY 15, 2000
<S>                              <C>                  <C>                    <C>                    <C>
Exercise Price                       $42.4375                $35.8750                $22.0000               $29.9375
Black-Scholes Value                  $26.3215                $22.3016                $13.6770               $19.0625

EXECUTIVE OFFICERS
Dennis B. Gillings                      3,664                   5,940                   3,188                  2,350
Santo J. Costa                          2,874                   4,003                   2,566                  1,149
Rachel R. Selisker                      1,189                   1,786                   1,148                    908
Ludo J. Reynders                        1,700                   2,228                   1,331                  1,096
John S. Russell                           (1)                     (1)                     717                    567
  TOTAL                                 9,427                  13,957                   8,233                  5,503
</TABLE>

- ----------------------

 (1)     John Russell became an executive officer of the Company in November
         1999. As a result Mr. Russell is not included in the first or second
         quarter figures of the table above.

         In order to determine the number of options to be granted, the
executive compensation plan performance award guidelines were used. The cash
award amount derived from applying the criteria was then converted into stock
options using the Black-Scholes method of option valuation. Using the
Black-Scholes method, each option was valued upon grant at approximately 62.5%
of the value of the underlying shares. The stock options vested on May 15, 2000.

         Performance award targets established for 1999 for the executive
officers, other than Dr. Gillings and Mr. Kever, averaged 47% of the executive
officers' aggregate base salaries. Based upon the achievement of these executive
officers' individual and corporate performance goals, the value of actual bonus
awards averaged 37.4% of their 1999 aggregate base salaries.

         In addition to the stock option grants made pursuant to the executive
compensation plan performance award guidelines, the Compensation Committee
considered on a broad basis the desirability of granting additional options for
retaining and incenting employees in light of volatile market dynamics. The
Compensation Committee approved a November 5, 1999 grant of stock options to
employees, including the executive officers. In making these grants, the
Compensation Committee considered the performance of each executive officer
during the affected period to determine whether to grant some or any options to
that officer.

         Pursuant to Mr. Kever's employment contract, he was granted an option
to purchase 64,271 shares of Common Stock of the Company as part of his 1999
compensation. The option has a Black-Scholes value of $450,000, based on the
closing price of the Company's Common Stock on the date of grant, December 31,
1999. The exercise price of the option, $18.6875, is equal to the closing price
of the Company's Common Stock on the date of grant. The Company granted Mr.
Kever this option in lieu of the Company's standard performance and long term
incentive awards.


                                       21
<PAGE>   24


LONG-TERM INCENTIVE AWARDS

         The long-term incentive component of the Company's compensation scheme
is designed to motivate and reward executives for maximizing shareholder value
and encourage the long-term employment of key employees. Long-term incentives
primarily are provided pursuant to the Company's Equity Compensation Plan and
the Nonqualified Stock Option Plan, which are administered by the Compensation
Committee. Additional long-term incentive compensation is provided through the
ESOP.

         When awarding long-term incentives pursuant to the Equity Compensation
Plan and the Nonqualified Stock Option Plan, the Compensation Committee has
established target award guidelines for each level of executive. These targets
are designed to comport with compensation practices among mid-sized U.S. and
international companies in general industry. Actual awards may vary from the
target levels to account for unusual performance or potential or to meet special
hiring or retention needs.

         The Compensation Committee also considered the number of options held
by Mr. Costa, and when compared to his length of service and contributions to
the progress of the Company, the Compensation Committee determined that, in
keeping with his position and responsibilities, it was appropriate to make a
one-time grant of options to purchase 120,000 shares, in installments of 30,000
on March 14, 1999 and 90,000 shares on June 7, 1999 with exercise prices equal
to $40.19 and $42.44, respectively.

         In June 1999, the Compensation Committee approved grants of stock
options on a quarterly basis to Dr. Gillings, Mr. Costa, Ms. Selisker, Dr.
Reynders and Mr. Russell. The size of each award was determined in accordance
with the target award guidelines discussed above. These options vest on the
anniversaries of the grant date over a four year period (25% of the grant each
year). Since these options carry exercise prices equal to the fair market value
of the Company's Common Stock on the date of grant, the stock options have value
only if the stock price appreciates from the value on the date the options were
granted. This feature is intended to focus executives on the enhancement of
shareholder value over the long-term and to encourage equity ownership in the
Company.

BENEFITS

         Benefits offered to executives serve a different purpose than do the
other elements of executive compensation. In general, they are designed to
provide a safety net of protection against the financial catastrophes that can
result from illness, disability or death and to provide a reasonable level of
retirement income. Benefits offered to executives are largely those that are
offered to the general employee population, with some variation primarily to
promote tax efficiency.


                                      22
<PAGE>   25


CHIEF EXECUTIVE OFFICER ("CEO") COMPENSATION

         The Compensation Committee has adopted the policies described above
with respect to Dr. Gillings, whose base salary rate at December 31, 1999 was
$568,749 and whose performance award for 1999 (awarded in stock options) covered
15,142 shares of the Company's Common Stock. The size of his performance award
was based on the extent to which the Company achieved its operating surplus
targets and net revenue targets, as well as Dr. Gillings' attainment of his
individual goals. The value of this award represents 55.79% of Dr. Gillings'
base salary. In addition, as more fully described below under the caption
"Employment Agreements," Dr. Gillings received split-dollar life insurance
benefits during 1999. The total of base salary, performance award opportunity
and life insurance benefits was established by the Compensation Committee at the
75th percentile of comparable pay for Chief Executive Officers in the contract
research organization, biotechnology and pharmaceutical industries. In setting
this amount, the Compensation Committee took into consideration Dr. Gillings'
industry experience and length of service, his vision, which has been
instrumental to the growth and success of the Company, and his leadership
ability, which resulted in the Company's successful public offerings and its
acquisition program. Dr. Gillings also received options to purchase 135,940
shares of Common Stock pursuant to the executive compensation plan, consistent
with the target long term incentive award guidelines adopted by the Compensation
Committee, as discussed above. In addition, Dr. Gillings received an allocation
to his ESOP account in accordance with the terms of the ESOP.

POLICY WITH RESPECT TO $1 MILLION DEDUCTION LIMIT

         The Company has not awarded any compensation that is non-deductible
under Section 162(m) of the Internal Revenue Code. That section imposes a $1
million limit on the U.S. corporate income tax deduction a publicly-held company
may claim for compensation paid to the named executive officers unless certain
requirements are satisfied. An exception to this limitation is available for
"performance-based" compensation, as defined under Section 162(m). Compensation
received as a result of the exercise of stock options may be considered
performance-based compensation if certain requirements of Section 162(m) are
satisfied. The Company has amended the Equity Compensation Plan so that
compensation related to stock options granted under that plan may qualify as
performance-based compensation and remain deductible. In the event that the
Compensation Committee considers approving compensation in the future which
would exceed the $1 million deductibility threshold, the Compensation Committee
will consider what actions, if any, should be taken to make such compensation
deductible.


                                       23
<PAGE>   26



CONCLUSION

         The Compensation Committee believes that these executive compensation
policies and programs effectively promote the Company's interests and enhance
shareholder value.

                             COMPENSATION COMMITTEE

                           ROBERT C. BISHOP, CHAIRMAN
                               CHESTER W. DOUGLASS
                               VIRGINIA V. WELDON




                                       24
<PAGE>   27



                      COMPARISON OF CUMULATIVE TOTAL RETURN

         The following graph compares the cumulative total shareholder return on
the Company's Common Stock since April 20, 1994, the effective date of the
Company's initial public offering, through December 31, 1999, with the
cumulative total return for the same period on the Nasdaq Stock Market (U.S.)
Index and the Nasdaq Health Services Index. The graph assumes that at the
beginning of the period indicated, $100 was invested in the Company's Common
Stock and the stock of the companies comprising the Nasdaq Stock Market (U.S.)
Index and the Nasdaq Health Services Index and that all dividends were
reinvested.

                       SHAREHOLDER RETURN ON COMMON STOCK

                                    [CHART]


    COMPARISON OF CUMULATIVE TOTAL RETURN AMONG QUINTILES TRANSNATIONAL CORP.
          AND THE NASDAQ U.S. STOCK AND NASDAQ HEALTH SERVICES INDICES

<TABLE>
<CAPTION>
                                         QTRN                 NASDAQ U.S.          NASDAQ Health
                                                                                    Services
                <S>                      <C>                  <C>                  <C>
                04/20/1994               $   100                 $  100                    $ 100
                12/31/1994               $   150                 $  107                    $ 108
                12/31/1995               $   421                 $  152                    $ 137
                12/31/1996               $   679                 $  187                    $ 137
                12/31/1997               $   785                 $  229                    $ 140
                12/31/1998               $ 1,095                 $  323                    $ 118
                12/31/1999               $   383                 $  583                    $  98
</TABLE>



                                       25
<PAGE>   28



EMPLOYMENT AGREEMENTS

         The Company has entered into employment agreements with Dr. Gillings,
Mr. Costa, Dr. Reynders, Ms. Selisker and Mr. Kever. The named executive
officers are eligible to participate in any bonus, stock option, pension,
insurance, medical, dental, 401(k), disability and other plans generally made
available to the Company's executives.

         The employment agreement for Dr. Gillings extends for three years from
February 22, 1994 and automatically renews for additional and successive
one-year terms unless either party provides 90 days' notice of intent to
terminate prior to the expiration of the then-current term. This agreement was
amended on October 26, 1999 to provide more detailed change in control
provisions. The agreement terminates upon Dr. Gillings' death, upon notice by
the Company if Dr. Gillings becomes permanently disabled, upon notice by the
Company for cause, upon notice by Dr. Gillings in the event of a change in
control, as defined in his employment agreement (provided Dr. Gillings
terminates his employment within 18 months following such change in control),
upon notice by Dr. Gillings in the event of the Company's material breach or
improper termination of the employment agreement and upon notice by Dr. Gillings
if Dr. Gillings is not elected as Chairman of the Board and Chief Executive
Officer of the Company. The agreement provides for severance payments and
continuation of benefits in the event Dr. Gillings' termination is for permanent
disability, change in control, breach or improper termination by the Company, or
for a change in position. In the event of termination by Dr. Gillings due to
permanent disability, breach or improper termination by the Company or for a
change in position, the Company must pay Dr. Gillings or his estate or
beneficiaries his full base salary then in effect and other benefits under the
agreement for the lesser of three years or the term of the non-compete covenant
provided in the agreement. In the event that Dr. Gillings terminates his
employment or is terminated by the Company without cause within 18 months
following a change in control, the Company must make a severance payment equal
to 2.99 times the amount of Dr. Gillings' base salary and executive compensation
plan benefits for the year of termination, continue his other benefit plans for
18 months and make a lump sum payment of any amounts held by Dr. Gillings in any
of the Company's retirement plans. In addition, upon a change in control, all
options held by Dr. Gillings will become fully vested and exercisable. The
Company is not obligated to make any payments or provide benefits to Dr.
Gillings if the termination is for cause. The agreement includes a three year
(or such lesser period as the Board determines, but in no event less than one
year) non-compete provision pursuant to which Dr. Gillings cannot compete with
the Company in any geographic area in which it does business and cannot solicit
or interfere with the Company's relationship with any person or entity doing
business with the Company, or offer employment to any person employed by the
Company in the one year period prior to Dr. Gillings' termination of employment.
The agreement prohibits disclosure of any confidential information acquired
during the period of employment with the Company.

         The Company entered into split-dollar life insurance agreements as of
May 16, 1996 with certain trusts created by Dr. Gillings, pursuant to which the
Company and the trusts will share in the premium costs of certain variable and
whole life insurance policies that pay an aggregate death benefit to the trusts
upon the death of Dr. Gillings or his wife, Joan Gillings, whichever occurs
later. The trusts pay premiums on the policies as if each policy were a one-year
term life




                                       26
<PAGE>   29


policy, and the Company pays the remaining premiums. The Company may cause this
arrangement to be terminated at any time upon 30 days' notice. Upon termination
of the arrangement, surrender of a policy, or payment of the death benefit under
a policy, the Company is entitled to repayment of an amount equal to the
cumulative premiums previously paid by the Company thereunder, with all
remaining amounts going to the trust. Upon any surrender of a policy, the
liability of the related trust to the Company is limited to the cash value of
the policy. See footnotes (4), (7) and (10) to the "Summary Compensation Table"
above for additional information on premium payments made by the Company under
the policies.

         Effective November 29, 1999, Mr. Costa ceased to be President and Chief
Operating Officer of the Company and became its Vice Chairman. His amended and
restated employment agreement, dated November 30, 1999, extends through December
31, 2001. The agreement terminates upon the death of Mr. Costa, upon notice by
the Company if Mr. Costa becomes permanently disabled, upon notice by the
Company for cause, upon notice by Mr. Costa in the event of a change in control,
as defined in his employment agreement (provided Mr. Costa terminates his
employment within 18 months following such change in control) and upon notice by
Mr. Costa in the event of the Company's material breach. The agreement provides
for severance payments and continuation of benefits in the event Mr. Costa's
employment is terminated prior to expiration of the agreement. In the event of
termination by Mr. Costa for reasons other than a change in control, the Company
must pay Mr. Costa his full base salary until December 31, 2001, any annual
bonus, prorated to the date of termination, and other benefits under the
agreement, subject to certain limitations and exceptions. In the event that Mr.
Costa terminates his employment or is terminated by the Company without cause
within 18 months after a change in control, the Company must make a severance
payment equal to 2.99 times the annual average amount of Mr. Costa's
compensation for the two most recent fiscal years, including executive
compensation plan benefits, as well as continue his other benefit plans for 18
months and make a lump sum payment of any amounts held by Mr. Costa in any of
the Company's retirement plans. In addition, upon a change in control, all
options held by Mr. Costa will become fully vested and exercisable. The Company
is not obligated to make any payments or provide benefits to Mr. Costa if the
termination is for cause. The agreement includes a one-year non-compete
provision following termination of employment and prohibits disclosure of
confidential information.

         Dr. Reynders' employment agreement, which was amended and restated on
March 17, 2000, calls for Dr. Reynders to serve as Chief Executive Officer,
Quintiles CRO Service Group. The agreement automatically renews for successive
one-year terms, unless either party provides 90 days notice prior to the renewal
date of intent to terminate. The agreement is terminable by the Company for
cause. Either party may terminate the agreement at any time by providing the
other party with 90 days written notice. If Dr. Reynders terminates the
employment relationship as a result of the Company's failure to cure a material
breach of the agreement after 30 days notice of such breach, he is entitled to
an amount equal to his then current salary for 12 months. In the event that Dr.
Reynders terminates his employment or is terminated by the Company without cause
within 18 months after a change in control, as defined in the agreement, the
Company must make a severance payment equal to 2.99 times the amount of his base
salary and executive compensation plan benefits for the year of termination,
continue his other benefit plans


                                       27
<PAGE>   30


for 18 months and make a lump sum payment of any amounts held by Dr. Reynders in
any of the Company's retirement plans. In addition, upon a change in control,
all options held by Dr. Reynders will become fully vested and exercisable. The
agreement includes a one-year non-compete provision following termination of
employment and prohibits disclosure of confidential information.

         Ms. Selisker's employment agreement, dated January 1, 1995, extends for
successive one-year intervals unless terminated by either party with 90 days
written notice. This employment agreement was amended on October 25, 1999 to
provide more detailed change in control provisions. Ms. Selisker has resigned
her position as Chief Financial Officer and will serve as a senior consultant in
the creation of the Company's global shared services centers for finance and
human resources. Her employment agreement, however, remains in effect until
superseded by a replacement agreement. The January 1, 1995 agreement, as
amended, terminates automatically upon Ms. Selisker's attaining the age of 65,
her death, total and permanent disability, a material breach of her employment
agreement that is not cured within 30 days of written notice, acts of
dishonesty, commission of certain crimes or failure to perform her duties under
the agreement. The agreement provides for severance payments and continuation of
benefits in the event that either the Company voluntarily terminates the
agreement by giving notice of its intention not to renew, in the event of Ms.
Selisker's total and permanent disability or if Ms. Selisker terminates after a
material breach by the Company which it fails to cure within 30 days. In the
event that Ms. Selisker terminates her employment or is terminated by the
Company without cause within 18 months following a change in control, as defined
in the agreement, the Company must make a severance payment equal to 2.99 times
the amount of Ms. Selisker's base salary and executive compensation plan
benefits for the year of termination, continue her other benefit plans for 18
months and make a lump sum payment of any amounts held by Ms. Selisker in any of
the Company's retirement plans. In addition, upon a change in control, all
options held by Ms. Selisker will become fully vested and exercisable. The
agreement includes a one year non-compete provision and prohibits Ms. Selisker
from soliciting or interfering with the Company's relationship with any person
doing business with the Company or offering employment to any person employed by
the Company in the one year period prior to Ms. Selisker's termination of
employment.

         Mr. Kever's employment agreement terminates three years from March 30,
1999. This employment agreement was amended on November 23, 1999 to provide more
detailed change in control provisions. The agreement gives the Company the
ability to terminate Mr. Kever's employment at any time for any reason, and Mr.
Kever may resign at any time. Upon termination by ENVOY or resignation by Mr.
Kever for any reason other than in connection with change in control, as defined
in the agreement, of the Company, Mr. Kever is entitled to receive his base
salary and cash bonus, as defined in the agreement, for the remainder of the
term of the agreement, payable in the same amounts and at the same times as if
the employment had not terminated. In the event that Mr. Kever terminates his
employment or is terminated by the Company without cause within 18 months
following a change in control the Company must make a severance payment equal to
2.99 times the amount of Mr. Kever's base salary and executive compensation plan
benefits for the year of termination, continue his other benefit plans for 18
months and make a lump sum payment of any amounts held by Mr. Kever in any of
the




                                       28
<PAGE>   31



Company's retirement plans. In addition, upon a change in control, all options
held by Mr. Kever will become fully vested and exercisable. The agreement
includes a non-compete that extends from the later of (1) the last day of the
employment agreement's three year term or (2) 18 months following Mr. Kever's
termination or resignation. This non-compete provision prohibits Mr. Kever from
competing against the Company in any geographical area in which it does business
or soliciting or hiring any of the Company's employees. Mr. Kever's employment
agreement prohibits disclosure of any confidential information acquired in the
course of his employment.


                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         On March 30, 1999, the Company acquired all of the outstanding shares
of ENVOY in exchange for approximately 28,465,160 shares of the Company's Common
Stock. Fred C. Goad, Jim D. Kever and William E. Ford served as directors of
ENVOY prior to the share exchange and currently serve as directors of the
Company. In addition, Mr. Goad served as ENVOY's Chairman and Co-Chief Executive
Officer and Mr. Kever served as ENVOY's President and Co-Chief Executive
Officer. As a result of the share exchange, Mr. Goad received 209,715 shares of
the Company's Common Stock and fully vested stock options covering 711,260
shares of the Company's Common Stock. In addition, a trust of which Mr. Goad is
the trustee and a sole beneficiary received 89,432 shares of the Company's
Common Stock and Mr. Goad's wife received 15,304 shares of the Company's Common
Stock. Mr. Kever received 468,181 shares of the Company's Common Stock and fully
vested stock options covering 635,470 shares of the Company's Common Stock. In
addition, a trust for Mr. Kever's children of which Mr. Kever is the trustee
received 69,960 shares of the Company's Common Stock. GAP 25, whose general
partner is GAP LLC, of which Mr. Ford is a managing member, received 2,818,421
shares of the Company's Common Stock and GAPCO, of which Mr. Ford is a general
partner, received 446,378 shares of the Company's Common Stock. Mr. Ford
received fully vested stock options covering 4,464 shares of the Company's
Common Stock. All of the stock options received in the share exchange by Messrs.
Goad, Kever and Ford became exercisable immediately.

         In connection with the ENVOY share exchange, Mr. Goad resigned as
ENVOY's Chairman and Co-Chief Executive Officer which entitled him to receive
certain payments under the terms of his Amended and Restated Employment
Agreement with ENVOY dated January 1, 1994. Pursuant to that agreement, ENVOY
paid Mr. Goad a lump sum payment of $1,132,463. Mr. Goad is also entitled to
receive reimbursement for certain expenses and benefits, including reimbursement
for excise taxes, if any, that may be incurred by Mr. Goad in connection with
the lump sum payment or acceleration of stock options under that agreement. Mr.
Goad remains subject to non-competition restrictions contained in that
agreement.

         Effective March 15, 1995, A.M. Pappas & Associates, LLC, or AMP&A,
entered into a consulting agreement with the Company. The 1995 Consulting
Agreement superseded the July 11, 1994 consulting agreement. In compliance with
the terms of the 1995 Consulting Agreement, the Company granted Mr. Pappas stock
options on March 15, 1995 covering 40,000 shares of the Company's Common Stock
at an exercise price of $8.75 per share which vested


                                       29
<PAGE>   32


50% on March 15, 1995, 75% on March 15, 1996 and 100% on March 15, 1997. Fifty
percent of the fees invoiced during any twelve-month period are deemed satisfied
by the stock options granted on March 15, 1995 as described above up to a
maximum of $100,000 per twelve-month period. Between the expiration of the 1995
consulting agreement in March 1998 and the execution of a replacement agreement
on January 1, 2000, AMP&A continued to provide the Company with consulting
services substantially in accordance with the terms of the 1995 agreement. In
1999, the Company paid consulting fees of $195,385 in cash. On January 1, 2000,
the Company entered into a new consulting agreement with AMP&A. The 2000
consulting agreement calls for a minimum aggregate consulting fee (exclusive of
expenses) per year of $200,000, and AMP&A has agreed not to invoice the Company
for more than $220,000 per year without the Company's prior consent. The Company
has agreed to reimburse AMP&A for all reasonable out-of-pocket and
administrative expenses incurred by AMP&A in connection with performing its
services.

         The Company is a limited partner in TechAMP International, L.P., a fund
organized to make venture capital investments in the equity securities of
private companies in the life science sector. TechAMP is managed by its general
partner, AMP&A Management, LLC, an affiliate of AMP&A. The Company has committed
to invest an aggregate of $8,000,000 in TechAMP. As a limited partner, the
Company will make capital contributions under this commitment from time to time
at the request of the fund's general partner. In 1999, the Company made capital
contributions of $2,424,000 to TechAMP.

         In November 1997, the Company signed a preferred provider agreement
with The Cleveland Clinic Foundation, pursuant to which The Cleveland Clinic
will work with the Company as a preferred provider for investigator services in
certain therapeutic areas, including cardiology, AIDS, cancer and molecular
genetics, and the Company will work with The Cleveland Clinic as a preferred
provider for contract drug development services. Dr. Topol is Chairman of the
Department of Cardiology and a co-director of the Heart Center at The Cleveland
Clinic. In 1999, pursuant to the 1997 preferred provider agreement, the Company
incurred fees of $192,604, all of which were paid in 1999.


                                  SECTION 16(A)
                    BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         Section 16(a) of the Securities Exchange Act of 1934, as amended,
requires the Company's executive officers and directors to file reports of
ownership and changes in ownership with the Securities and Exchange Commission.
Based on a review of the report forms that were filed, the Company believes that
during 1999 all filing requirements applicable to the Company's executive
officers and directors were complied with except that each of Santo J. Costa,
Greg Porter and David White reported late to the Securities and Exchange
Commission the acquisition or sale of certain shares of the Company's Common
Stock.


                                       30
<PAGE>   33
                      PROPOSAL 2: APPROVAL OF THE COMPANY'S
                        1999 EMPLOYEE STOCK PURCHASE PLAN

GENERAL

         The Board of Directors of the Company adopted the 1999 Employee Stock
Purchase Plan (the "1999 Plan") effective September 30, 1999. The 1999 Plan is
subject to the approval of the shareholders of the Company solely for the
purpose of qualifying options granted under the 1999 Plan under Section 423 of
the Internal Revenue Code of 1986, as amended (the "Code"). The 1999 Plan
supersedes the Company's prior Employee Stock Purchase Plan, which the Board
terminated effective September 30, 1999. The remaining pool of shares reserved
for issuance under that plan was cancelled at that time.

         The 1999 Plan provides eligible employees of the Company and its U.S.
subsidiaries with an opportunity to purchase shares of the Company's Common
Stock through regular payroll deductions. The Company has reserved 2,500,000
shares of the Company's Common Stock for issuance under the 1999 Plan. On May
12, 2000, the closing sale price of a share of the Company's Common Stock on the
Nasdaq National Market was $13.563.

ELIGIBILITY AND PARTICIPATION; ADMINISTRATION

         Each current full-time, part-time or temporary employee who has
completed six consecutive months of employment with the Company or any eligible
subsidiary of the Company is eligible to participate in the 1999 Plan. However,
no employee may be granted an option to purchase shares of Common Stock under
the 1999 Plan (a) if, immediately after the grant, the employee would own stock
and/or hold outstanding options to purchase stock possessing 5% or more of the
total combined voting power or value of all classes of stock of the Company, or
(b) which permits the employee's rights to purchase stock under all stock
purchase plans of the Company to accrue at a rate that exceeds $25,000 of fair
market value of the stock (determined at the time such option is granted) for
each calendar year in which such option is outstanding at any time. Only
employees of the Company and its U.S. subsidiaries are eligible to participate
in the 1999 Plan. As of December 31, 1999, there were approximately 3,000
participants in the 1999 Plan.

         An eligible employee may become a participant in the 1999 Plan by
submitting an authorization for payroll deductions prior to the commencement of
any quarterly offering under the 1999 Plan. Each participant may elect payroll
deductions of 0% or any whole percentage from 1% to 15% of such participant's
gross base compensation, including amounts deferred under any salary reduction
plan of the Company (but excluding bonus payments, automobile and other
allowances, compensation paid in forms other than cash and similar
compensation). Payroll deductions elected by a participant are credited to an
account established for the participant under the 1999 Plan. Unless expressly
permitted for all participants upon written approval of the Compensation
Committee, no participant may make any separate cash payments to his or her
account. All payroll deductions received or held by the Company under the 1999

                                       31
<PAGE>   34

Plan may be used by the Company for any corporate purpose and are subject to the
claims of the Company's creditors.

         The 1999 Plan is implemented through four quarterly offerings each
calendar year. On the first day of each offering, each participant is deemed to
have been granted an option to purchase a number of shares of Common Stock equal
to the participant's accumulated payroll deductions during the offering divided
by the applicable option price per share of Common Stock. The option price is
85% of the lower of the closing price per share of Common Stock on the first or
last day of the offering. On the last day of the offering, each participant is
deemed to have exercised his or her option for the number of full shares of
Common Stock that his or her accumulated payroll deductions can purchase at the
applicable option price. Fractional shares are not issued under the 1999 Plan.
Any accumulated payroll deductions that would have been used to purchase
fractional shares are held without interest for the purchase of Common Stock in
the next offering. A participant may change his or her future payroll deductions
or stop participating in the 1999 Plan at any time. Options granted under the
1999 Plan are not transferable except by will or by the laws of descent and
distribution. Options are subject to appropriate and proportionate adjustments
in the event of any reorganization, merger, consolidation, recapitalization,
reclassification, stock split, reverse stock split or similar transaction
affecting the Company's Common Stock. The 1999 Plan is administered by the
Compensation Committee of the Company.

AMENDMENT AND TERMINATION

         The 1999 Plan may be amended or terminated by the Board of Directors of
the Company at any time. However, the Board generally may not amend or terminate
the 1999 Plan in a manner that adversely affects a participant's rights
thereunder without such participant's consent, except that the Board may amend
the 1999 Plan to rectify any potentially unfavorable financial accounting
consequences that may result from the 1999 Plan.

CERTAIN FEDERAL TAX CONSEQUENCES

         The 1999 Plan is intended to comply with the requirements governing
employee stock purchase plans set forth in the Code. Certain favorable tax
consequences are afforded purchasers of stock pursuant to an employee stock
purchase plan meeting those requirements. If a participant acquires stock under
such a plan and holds it for a period of more than two years from the date the
option is granted and more than one year from the date the option is exercised,
the participant does not recognize any ordinary income on grant or exercise. The
participant recognizes ordinary income upon the disposition of such stock to the
extent of the lesser of the excess of the fair market value of such stock at the
time the option was granted over its option price or the excess of the sale
proceeds over the option price. The participant recognizes any additional gain
or loss as capital gain (or loss).

         Neither the grant of an option under an employee stock purchase plan
meeting the requirements in the Code, the exercise of such an option nor a
disposition of the stock after the holding period requirements described above
have been satisfied has tax consequences to the

                                       32
<PAGE>   35

Company. If a participant disposes of stock acquired pursuant to such an option
within two years from the date the option is granted or one year from the date
the option is exercised, the participant recognizes as ordinary income the
difference between the option price and the fair market value of the stock at
the time the option is exercised. The Company is entitled to a corresponding
income tax deduction in that amount.

         Assuming the presence of a quorum, approval of the 1999 Plan requires
the affirmative vote, either in person or by proxy, of at least a majority of
all shares of the Company's Common Stock voted at the Annual Meeting. The
presence at the Annual Meeting, either in person or by proxy, of the holders of
a majority of the votes entitled to be cast at such meeting will constitute a
quorum for the transaction of business. Abstentions will be treated as shares
that are present and entitled to vote for purposes of determining the presence
of a quorum. However, under North Carolina corporate law, abstentions are
treated as non-votes in determining whether shareholders have approved a
proposal.

THE BOARD OF DIRECTORS RECOMMENDS THAT THE SHAREHOLDERS VOTE FOR THE APPROVAL OF
THE COMPANY'S 1999 EMPLOYEE STOCK PURCHASE PLAN.

                     PROPOSAL 3: RATIFICATION OF APPOINTMENT
                        OF INDEPENDENT PUBLIC ACCOUNTANTS

         The Board of Directors has appointed Arthur Andersen LLP as independent
public accountants for fiscal year 2000. Ernst & Young LLP served as independent
auditors for the Company from 1990 through 1997. Ernst & Young LLP was notified
on February 26, 1998 that the Company was changing independent public
accountants.

         During the Company's two fiscal years ended December 31, 1997, and the
subsequent interim period prior to February 26, 1998, there were no
disagreements with Ernst & Young LLP on any matter of accounting principles or
practices, financial statement disclosure, or auditing scope or procedures,
which if not resolved to their satisfaction would have caused them to make
reference to the subject matter of the disagreements in connection with their
opinion.

         The audit report of Ernst & Young LLP on the consolidated financial
statements of the Company for the years ended December 31, 1996 and 1997 did not
contain any adverse opinion or disclaimer of opinion, nor was it qualified or
modified as to uncertainty, audit scope or accounting principles. At the
Company's request, Ernst & Young LLP provided the Company with a letter to the
Securities and Exchange Commission, dated March 20, 1998, a copy of which was
filed as an exhibit to the Company's Current Report on Form 8-K dated February
26, 1998, as amended on March 20, 1998, pursuant to which Ernst & Young LLP
agreed with the above statements.

         Although shareholder approval is not required, the Company desires to
obtain from the shareholders an indication of their approval or disapproval of
the Board's action in appointing Arthur Andersen LLP as the independent public
accountants of the Company and its subsidiaries. If the shareholders do not
ratify this appointment, such appointment will be reconsidered by the

                                       33
<PAGE>   36

Audit Committee and the Board of Directors. The proxy will be voted as
specified, and if no specification is made, the proxy will be cast "For" this
proposal.

         A representative of Arthur Andersen LLP will be present at the Annual
Meeting and will be afforded an opportunity to make a statement and to respond
to questions.

THE BOARD OF DIRECTORS RECOMMENDS THAT THE SHAREHOLDERS VOTE FOR THE
RATIFICATION OF THE APPOINTMENT OF ARTHUR ANDERSEN LLP FOR FISCAL YEAR 2000.



                     SUBMISSION OF SHAREHOLDER PROPOSALS FOR
                       2001 ANNUAL MEETING OF SHAREHOLDERS

         Any proposals which shareholders intend to present for a vote of
shareholders at the 2001 Annual Meeting of Shareholders and which such
shareholders desire to have included in the Company's Proxy Statement and form
of proxy relating to that meeting must be sent to the Company's principal
executive offices, marked to the attention of the Secretary of the Company, and
received by the Company at such offices on or before January 23, 2001. The
determination by the Company of whether it will oppose inclusion of any proposal
in its Proxy Statement and form of proxy will be made on a case-by-case basis in
accordance with its judgment and the rules and regulations promulgated by the
Securities and Exchange Commission. Proposals received after January 23, 2001
will not be considered for inclusion in the Company's proxy materials for its
2001 Annual Meeting. In addition, if a shareholder intends to present a matter
for a vote at the 2001 Annual Meeting of Shareholders, other than by submitting
a proposal for inclusion in the Company's Proxy Statement for that meeting, the
shareholder must give timely notice in accordance with the Company's Bylaws. To
be timely, a shareholder's notice must be received by the Secretary of the
Company at the Company's principal executive offices not more than ninety (90)
days and not less than fifty (50) days before the meeting. The Company's Bylaws
provide that an annual meeting may be held in any month. The Company has
historically held its meeting in May, however, the 2000 annual meeting will be
held in June as was the 1999 annual meeting. Any such shareholder's notice
should set forth (a) as to each matter the shareholder proposes to bring before
the meeting, a brief description of the business desired to be brought before
the meeting and the reasons for conducting such business at the meeting, and (b)
the name and record address of the shareholder, the class and number of shares
of Common Stock of the Company that are beneficially owned by the shareholder,
and any material interest of the shareholder in such business.

                                       34
<PAGE>   37

                                  MISCELLANEOUS

         The Annual Report of the Company for the year ended December 31, 1999,
which includes financial statements audited and reported upon by the Company's
independent public accountants, is being mailed along with this Proxy Statement;
however, it is not intended that the Annual Report be a part of this Proxy
Statement or a solicitation of proxies.

                       AVAILABILITY OF REPORT ON FORM 10-K

         A copy of the Company's Annual Report on Form 10-K for the year ended
December 31, 1999 will be furnished without charge to any shareholder upon
written request directed to Investor Relations, Quintiles Transnational Corp.,
P. O. Box 13979, Research Triangle Park, North Carolina 27709-3979.

                                    By Order of the Board of Directors

                                    John S. Russell
                                    Senior Vice President and General Counsel,
                                    Head Global Human Resources,
                                    Corporate Secretary

Durham, North Carolina
May 22, 2000

                                       35
<PAGE>   38

                                                                      APPENDIX A

                            - FOLD AND DETACH HERE -

                         QUINTILES TRANSNATIONAL CORP.

    PROXY FOR 2000 ANNUAL MEETING OF SHAREHOLDERS SOLICITED BY THE BOARD OF
                                   DIRECTORS

    The undersigned hereby appoints Dennis B. Gillings, Ph.D. and Santo J. Costa
and each of them as attorney and proxy of the undersigned, each with the full
power of substitution, to represent the undersigned and to vote all of the
shares of stock in Quintiles Transnational Corp. which the undersigned is
entitled to vote at the Annual Meeting of Shareholders to be held at the
Marriott at Research Triangle Park, 4700 Guardian Dr., Durham, North Carolina
27703 on Monday, June 19, 2000 at 5:00 p.m., Eastern Daylight Saving Time, and
any adjournments thereof (1) as hereinafter specified upon the proposals listed
below and as more particularly described in the Company's Proxy Statement,
receipt of which is hereby acknowledged; and (2) in their discretion upon such
other matters as may properly come before the meeting and any adjournment
thereof.

    THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE PROPOSALS LISTED BELOW.

1. Election of Class III Directors:

   [ ] FOR all nominees listed below          [ ] WITHHOLD AUTHORITY to vote
       (except as indicated to the contrary).     for all nominees listed below.

   Dennis B. Gillings, Ph.D., Chester W. Douglass, Ph.D.,
   Virginia V. Weldon, M.D., and Fred C. Goad, Jr.

   INSTRUCTION: To withhold authority to vote for any individual nominee,
   write that nominee's name on the space provided below:
   ______________________________________________________________________

2. Approve the Company's 1999 Employee Stock Purchase Plan:

             [ ] FOR            [ ] AGAINST            [ ] ABSTAIN

3. Ratify appointment of Arthur Andersen LLP as independent public accountants
   for the Company and its subsidiaries for the fiscal year ending December 31,
   2000:

             [ ] FOR            [ ] AGAINST            [ ] ABSTAIN

                  (Continued and to be signed on the reverse)
<PAGE>   39

                            - FOLD AND DETACH HERE -

                          (Continued from other side)

    By signing the proxy, a shareholder will also be authorizing the proxy
holder to vote in his discretion regarding any procedural motions which may come
before the Annual Meeting. For example, this authority could be used to adjourn
the meeting if the Company believes it is desirable to do so. Adjournment or
other procedural matters could be used to obtain more time before a vote is
taken in order to solicit additional proxies or to provide additional
information to shareholders. The Company has no current plans to adjourn the
meeting, but would attempt to do so if the Company believes that adjournment
would promote shareholder interests.

PLEASE SIGN EXACTLY AS YOUR NAME APPEARS BELOW. WHEN SHARES ARE HELD BY JOINT
TENANTS, BOTH SHOULD SIGN.

                                              DATE                       , 2000
                                                  -----------------------
                                                  (Be sure to date Proxy)

                                              ----------------------------------
                                              Signature and title, if applicable

                                              ----------------------------------
                                              Signature if held jointly

                                              When signing as attorney,
                                              executor, administrator, trustee
                                              or guardian, please give full
                                              title as such. If a corporation,
                                              please sign the full corporate
                                              name by the President or other
                                              authorized officer. If a
                                              partnership, please sign in the
                                              partnership name by an authorized
                                              person.

PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY USING THE ENCLOSED
ENVELOPE.
<PAGE>   40





                                                                      APPENDIX B

                          QUINTILES TRANSNATIONAL CORP.
                        1999 EMPLOYEE STOCK PURCHASE PLAN


                                    ARTICLE I
                                  INTRODUCTION

         1.01 Purpose. The 1999 Employee Stock Purchase Plan (the "Plan") of
Quintiles Transnational Corp. (the "Company") is intended to provide a method
whereby employees of the Company and its Eligible Subsidiary Corporations (as
defined below) shall have an opportunity to acquire a proprietary interest in
the Company through the purchase of shares of the common stock (the "Common
Stock") of the Company.

         1.02 Rules of Interpretation. It is the intention of the Company to
have the Plan qualify as an "employee stock purchase plan" under Section 423 of
the Internal Revenue Code of 1986, as amended (the "Code"). Except as expressly
provided in Section 12.06 below, the provisions of the Plan shall be construed
so as to extend and limit participation in a manner consistent with the
requirements of that section of the Code.


                                   ARTICLE II
                                   DEFINITIONS

         2.01 "Compensation" shall mean gross base compensation plus overtime,
shift premiums and commissions. "Compensation" shall include any amounts
otherwise excluded from compensation pursuant to any salary reduction plan of
the Company. "Compensation" shall not include bonus payments, automobile and
other allowances, compensation paid in forms other than cash, and similar
compensation.

         2.02 "Committee" shall mean the individuals described in Article XI.

         2.03 "Eligible Subsidiary Corporation" shall mean each Subsidiary
Corporation the employees of which are entitled to participate in the Plan, as
listed or referred to on Schedule 2.03 hereto.

         2.04 "Employee" shall mean any person employed by the Company or any
Eligible Subsidiary Corporation, including any full-time, part-time or temporary
employee.

         2.05 "Plan Representative" shall mean any person designated from time
to time by the Committee to receive certain notices and take certain other
administrative actions relating to participation in the Plan.

         2.06 "Subsidiary Corporation" shall mean any present or future
corporation that (i) is or becomes a "subsidiary corporation" of Quintiles
Transnational Corp. as that term is defined in Section 424 of the Code.


<PAGE>   41

                                   ARTICLE III
                          ELIGIBILITY AND PARTICIPATION

         3.01 Initial Eligibility. Each Employee who has completed six
consecutive months of employment with the Company or any corporation or entity
acquired by the Company or any Eligible Subsidiary Corporation and is employed
by the Company or any Eligible Subsidiary Corporation on the date his or her
participation in the Plan is to become effective shall be eligible to
participate in Offerings (as defined below) under the Plan that commence after
such six-month period has concluded. Persons who are not Employees shall not be
eligible to participate in the Plan.

         3.02 Eligibility upon Subsequent Employment. An Employee whose
employment terminates after he or she has satisfied the service requirements set
forth in Section 3.01 above and who subsequently is employed by the Company or
any Eligible Subsidiary Corporation shall not be required to satisfy such
service requirements again but shall be eligible to participate in the first
Offering (as defined below) that commences on or after the first day of such
subsequent employment.

         3.03 Restrictions on Participation. Notwithstanding any provision of
the Plan to the contrary, no Employee shall be granted an option to purchase
shares of Common Stock under the Plan:

                  (a) if, immediately after the grant, such Employee would own
stock and/or hold outstanding options to purchase stock possessing 5% or more of
the total combined voting power or value of all classes of stock of the Company
(for purposes of this paragraph, the rules of Section 424(d) of the Code shall
apply in determining stock ownership of any Employee); or

                  (b) to the extent that such Employee's rights to purchase
stock under all Employee stock purchase plans of the Company accrue at a rate
that exceeds $25,000 of fair market value of the stock (determined at the time
such option is granted) for each calendar year in which such option is
outstanding at any time.

         3.04 Commencement of Participation. An eligible Employee may become a
participant by completing an authorization for payroll deductions on the form
provided by the Company and filing the completed form with the Plan
Representative on or before the filing date set therefor by the Committee, which
date shall be prior to the Offering Commencement Date for the next following
Offering (as such terms are defined below). Payroll deductions for a participant
shall commence on the next following Offering Commencement Date after the
Employee's authorization for payroll deductions becomes effective and shall
continue until termination of the Plan or the participant's earlier termination
of participation in the Plan. Each participant in the Plan shall be deemed to
continue participation until termination of the Plan or such participant's
earlier termination of participation in the Plan pursuant to Article VIII below.


                                       2
<PAGE>   42

                                   ARTICLE IV
                     STOCK SUBJECT TO THE PLAN AND OFFERINGS

         4.01 Stock Subject to the Plan. Subject to the provisions of Section
12.04 of the Plan, the board of directors of the Company (the "Board) shall
reserve initially for issuance under the Plan an aggregate of two million five
hundred thousand (2,500,000) shares of Common Stock, which shares shall be
authorized but unissued shares of Common Stock. The number of shares reserved
under the Plan shall not include any shares approved by the shareholders of the
Company for issuance under any other employee stock purchase plan of the
Company. The Board may from time to time reserve additional shares of authorized
and unissued Common Stock for issuance pursuant to the Plan; provided, however,
that at no time shall the number of shares of Common Stock reserved be greater
than permitted by applicable law.

         4.02 Offerings. Except as described below with respect to the first
year the Plan is in effect, the Plan shall be implemented by four annual
offerings (the "Offerings") of the Company's Common Stock each calendar year.
There shall be only one Offering in calendar 1999, which shall begin on October
1, 1999 and end on December 31, 1999. Thereafter, in each year that the Plan is
in effect, the first Offering shall begin on January 1 and end on March 31, the
second Offering shall begin on April 1 and end on June 30, the third Offering
shall begin on July 1 and end on September 30, and the fourth Offering shall
begin on October 1 and end on December 31. The first day of each Offering shall
be deemed the "Offering Commencement Date" and the last day the "Offering
Termination Date" for such Offering.


                                    ARTICLE V
                               PAYROLL DEDUCTIONS

         5.01 Amount of Deduction. The form described in Section 3.04 shall
permit a participant to elect payroll deductions of zero percent (0%) or any
whole percentage from one percent (1%) through fifteen percent (15%) of such
participant's Compensation for each pay period during an Offering.

         5.02 Participant's Account. All payroll deductions made for a
participant shall be credited to an account established for such participant
under the Plan. Unless expressly permitted of all participants upon the written
approval of the Committee, no participant shall contribute any amount to the
Plan other than by means of payroll deductions. In the event that any such
additional contributions are permitted during an Offering, the provisions of the
Plan pertaining to payroll deductions shall govern such additional
contributions, as applicable.

         5.03 Changes in Payroll Deductions. A participant may reduce or
increase future payroll deductions (within the limits described in Section 5.01)
by filing with the Plan Representative a form provided by the Company for such
purpose. The effective date of any increase or reduction in future payroll
deductions shall be the first day of the next pay period succeeding processing
of the change form.

                                       3
<PAGE>   43

                                   ARTICLE VI
                               GRANTING OF OPTION

         6.01 Number of Option Shares. On the Commencement Date of each Offering
period, each participating Employee shall be deemed to have been granted an
option to purchase a maximum number of shares of Common Stock equal to (i) that
percentage of the Employee's Compensation that the Employee has elected to have
withheld (ii) multiplied by the Employee's Compensation during the Offering and
(iii) divided by the applicable option price determined as provided in Section
6.02 below.

         6.02 Option Price. The option price (the "Offering Price") of Common
Stock purchased with payroll deductions made during any Offering period for a
participant therein shall be the lower of:

                  (a) 85% of the closing price of the stock on the Offering
Commencement Date for such Offering or the nearest prior business day on which
trading occurred on the Nasdaq National Market; or

                  (b) 85% of the closing price on the Offering Termination Date
for such Offering or the nearest prior business day on which trading occurred on
the Nasdaq National Market. If the Common Stock of the Company is not admitted
to trading on any of the aforesaid dates for which closing prices of the stock
are to be determined, then reference shall be made to the fair market value of
the stock on each such date, as determined on such basis as shall be established
or specified for the purpose by the Committee.


                                   ARTICLE VII
                               EXERCISE OF OPTION

         7.01     Automatic Exercise.

                  (a) Each Plan participant's option for the purchase of stock
with payroll deductions made during any Offering shall be deemed to have been
exercised automatically on the applicable Offering Termination Date for the
purchase of the number of full shares of Common Stock covered by the accumulated
payroll deductions in the participant's account at the applicable Option Price
(but not in excess of the number of shares for which outstanding options have
been granted to the participant pursuant to Section 6.01).

                  (b) Insufficient Shares. If the Committee determines that on a
given Offering Termination Date the number of shares with respect to which
options are to be exercised exceed the number of shares of Common Stock
available for purchase under the Plan either as of the Offering Commencement
Date or as of such Offering Termination Date, the Committee may, in its sole
discretion, provide that the Company shall make a pro rata allocation of the
shares of

                                       4
<PAGE>   44

Common Stock available for purchase on such Offering Commencement Date
or Offering Termination Date, as applicable, in as uniform a manner as shall be
practicable and as it shall determine in its sole discretion to be equitable
among all participants and terminate the Offering then in effect. The Committee
may make such pro rata allocations of the shares available on the Offering
Commencement Date of any applicable Offering period, notwithstanding any
authorization of additional shares for issuance under the Plan by the
shareholders subsequent to such Offering Commencement Date.

         7.02 Withdrawal of Account. No participant in the Plan shall be
entitled to withdraw any amount from the accumulated payroll deductions in his
or her account; provided, however, that a participant's accumulated payroll
deductions shall be refunded to the participant as and to the extent specified
in Section 8.01 below upon termination of such participant's participation in
the Plan.

         7.03 Fractional Shares. Fractional shares of Common Stock shall not be
issued under the Plan. Any accumulated payroll deductions that would have been
used to purchase fractional shares, unless refunded pursuant to Section 7.02
above, shall be held for the purchase of Common Stock in the next following
Offering, without interest.

         7.04 Exercise of Options. During a participant's lifetime, options held
by the participant shall be exercisable only by the participant.

         7.05 Delivery of Stock. As promptly as practicable after the Offering
Termination Date of each Offering period, the Company shall deliver to each
participant in such Offering, as appropriate, the shares of Common Stock
purchased therein upon exercise of such participant's option. The Company may
deliver such shares in certificates or book entry form, at the Company's sole
election.

         7.06 Stock Transfer Restrictions. To the extent approved by the
shareholders, the Plan is intended to satisfy the requirements of Section 423 of
the Code. A participant shall not obtain the benefits of this provision if such
participant disposes of shares of Common Stock acquired pursuant to the Plan
within two years from the Offering Commencement Date or within one year from the
date such Common Stock is purchased by the participant, whichever is later.

                                  ARTICLE VIII
                                   WITHDRAWAL

         8.01 In General. A participant may stop participating in the Plan at
any time by giving written notice to the Plan Representative. Upon processing of
any such written notice, no further payroll deductions shall be made from the
participant's Compensation during such Offering or thereafter unless and until
such participant elects to resume participation in the Plan by providing written
notice to the Plan Representative pursuant to Section 3.04 above. Such
participant's payroll deductions accumulated prior to processing of such notice
shall be applied toward purchasing full shares of Common Stock in the
then-current Offering as provided in Section 7.01

                                       5
<PAGE>   45

above. Any cash balance remaining after the purchase of shares in such Offering
shall be refunded promptly to such participant.

         8.02 Effect on Subsequent Participation. A participant's withdrawal
from any Offering shall not have any effect upon such participant's eligibility
to participate in any succeeding Offering or in any similar plan that may
hereafter be adopted by the Company and for which such participant is otherwise
eligible.

         8.03 Termination of Employment. Upon termination of a participant's
employment with the Company or any Eligible Subsidiary Corporation (as the case
may be) for any reason, including retirement or death, the participant's payroll
deductions accumulated prior to such termination, if any, shall be applied
toward purchasing full shares of Common Stock in the then-current Offering, and
any cash balance remaining after the purchase of shares in such Offering shall
be refunded to him or her, or, in the case of his or her death, to the person or
persons entitled thereto, and his or her participation in the Plan shall
terminate.


                                   ARTICLE IX
                                    INTEREST

         9.01 Payment of Interest. No interest shall be paid or allowed on any
money paid into the Plan or credited to the account of or distributed to any
participant.


                                    ARTICLE X
                                      STOCK

         10.01 Participant's Interest in Option Stock. No participant shall have
any interest in shares of Common Stock covered by any option held by such
participant until such option has been exercised as provided in Section 7.01
above.

         10.02 Registration of Stock. Shares of Common Stock purchased by a
participant under the Plan shall be registered in the name of the participant,
or, if the participant so directs by written notice to the Plan Representative
prior to the Offering Termination Date applicable thereto, in the names of the
participant and one such other person as may be designated by the participant,
as joint tenants with rights of survivorship or as tenants by the entireties, to
the extent permitted by applicable law.

         10.03 Restrictions on Exercise. The Board may, in its discretion,
require as conditions to the exercise of any option that the shares of Common
Stock reserved for issuance upon the exercise of such option shall have been
duly listed, upon official notice of issuance, upon a stock exchange or market,
and that either:

                  (a) a registration statement under the Securities Act of 1933,
as amended, with respect to said shares shall be effective; or

                                       6
<PAGE>   46

                  (b) the participant shall have represented at the time of
purchase, in form and substance satisfactory to the Company, that it is his or
her intention to purchase the shares for investment and not for resale or
distribution.


                                   ARTICLE XI
                                 ADMINISTRATION

         11.01 Appointment of Committee. The Board shall appoint a committee
(the "Committee") to administer the Plan, which shall consist solely of no fewer
than three "non-employee directors" (as defined in Rule 16b-3(b)(3)(i)
promulgated under the Securities Exchange Act of 1934, as amended).

         11.02 Authority of Committee. Subject to the express provisions of the
Plan, the Committee shall have plenary authority in its discretion to interpret
and construe any and all provisions of the Plan, to adopt rules and regulations
for administering the Plan, and to make all other determinations deemed
necessary or advisable for administering the Plan. The Committee's determination
of the foregoing matters shall be conclusive.

         11.03 Rules Governing the Administration of the Committee. The Board
may from time to time appoint members of the Committee in substitution for or in
addition to members previously appointed and may fill vacancies, however caused,
in the Committee. The Committee may select one of its members as its chairman,
shall hold its meetings at such times and places as it shall deem advisable, and
may hold telephonic meetings. All determinations of the Committee shall be made
by a majority of its members. A decision or determination reduced to writing and
signed by a majority of the members of the Committee shall be as fully effective
as if it had been made by a majority vote at a meeting duly called and held. The
Committee may appoint a secretary and shall make such rules and regulations for
the conduct of its business as it shall deem advisable.


                                   ARTICLE XII
                                  MISCELLANEOUS

         12.01 Death of a Participant. In the event of the death of a
participant, the Company shall deliver shares of Common Stock and/or cash under
the Plan to the executor or administrator of the estate of the participant. If
no such executor or administrator has been appointed (to the knowledge of the
Company), the Company, in its discretion, may deliver such shares of Common
Stock and/or cash to the spouse or to any one or more dependents of the
participant, in each case without any further liability of the Company
whatsoever under or relating to the Plan.

         12.02 Transferability. Neither payroll deductions credited to any
participant's account nor any option or rights with regard to the exercise of an
option to receive Common Stock under the Plan may be assigned, transferred,
pledged, or otherwise disposed of in any way by the

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participant other than by will or the laws of descent and distribution. Any such
attempted assignment, transfer, pledge or other disposition shall be without
effect, except that the Company may, in its discretion, treat such act as an
election to withdraw from participation in the Plan in accordance with Section
8.01.

         12.03 Use of Funds. All payroll deductions received or held by the
Company under the Plan may be used by the Company for any corporate purpose. The
Company shall not be obligated to segregate such payroll deductions.

         12.04    Adjustment Upon Changes in Capitalization.

                  (a) If, while any options are outstanding under the Plan, the
outstanding shares of Common Stock of the Company have increased, decreased,
changed into, or been exchanged for a different number or kind of shares or
securities of the Company through any reorganization, merger, recapitalization,
reclassification, stock split, reverse stock split or similar transaction,
appropriate and proportionate adjustments may be made by the Committee in the
number and/or kind of shares that are subject to purchase under outstanding
options and in the Option Price or Prices applicable to such outstanding
options. In addition, in any such event, the number and/or kind of shares that
may be offered in the Offerings described in Article IV hereof shall also be
proportionately adjusted. No such adjustments shall be made for or in respect of
stock dividends. For purposes of this paragraph, any distribution of shares of
Common Stock to shareholders in an aggregate amount of 20% or more of the
outstanding shares of Common Stock shall be deemed a stock split, and any
distribution of aggregate shares of less than 20% of the outstanding shares of
Common Stock shall be deemed a stock dividend.

                  (b) Upon the dissolution or liquidation of the Company, or
upon a reorganization, merger or consolidation of the Company with one or more
corporations as a result of which the Company is not the surviving corporation,
or upon a sale of substantially all of the property or capital stock of the
Company to another corporation, the holder of each option then outstanding under
the Plan shall thereafter be entitled to receive at the next Offering
Termination Date, upon the exercise of such option, for each share as to which
such option is exercised, as nearly as reasonably may be determined, the cash,
securities and/or property that a holder of one share of the Common Stock is
entitled to receive upon and at the time of such transaction. The Board shall
take such steps in connection with such transactions as the Board shall deem
necessary to assure that the provisions of this Section 12.04 shall thereafter
be applicable, as nearly as reasonably may be determined, in relation to the
said cash, securities and/or property as to which each such holder of any such
option might hereafter be entitled to receive.

         12.05    Amendment and Termination.

                  (a) The Board shall have sole power and authority to terminate
or amend the Plan; provided, however, that no such amendment or termination may
adversely affect options previously granted.

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                  (b) Without shareholder consent and without regard to whether
any participant rights may be considered to have been "adversely affected," the
Board or the Committee may change the Offering periods, limit the frequency
and/or number of changes permitted in the amount withheld during an Offering,
establish the exchange ratio applicable to amounts withheld in a currency other
than U. S. Dollars, permit payroll withholding in excess of the amount
designated by a participant in order to adjust for delays or mistakes in the
Company's processing of properly completed withholding elections, establish
reasonable waiting and adjustment periods and/or accounting and crediting
procedures to ensure that amounts applied toward the purchase of Common Stock
for each participant properly correspond to amounts withheld from the
participant's Compensation, and establish such other limitations and procedures
that the Board or the Committee determines in its sole discretion advisable and
that are consistent with the Plan.

                  (c) If the Board determines that the ongoing operation of the
Plan may result in unfavorable financial accounting consequences, the Board may,
in its discretion and to the extent necessary or desirable, modify or amend the
Plan to reduce or eliminate such accounting consequences, including, but not
limited to:

                    (i) increasing the purchase price for any Offering,
including an Offering underway at the time of the change in purchase price;

                    (ii) shortening any Offering period so that the Offering
period ends on a new Offering Termination Date, including an Offering period
underway at the time of the Board action; and

                    (iii) allocating shares.

                    Such modifications or amendments shall not require
shareholder approval or the consent of any Plan participants.

         12.06 Shareholder Approval. Solely for the purpose of qualifying the
Plan under Section 423 of the Code, the Company shall seek shareholder approval
of the Plan. In the event that such shareholder approval is not obtained, the
plan shall be treated as a nonqualified plan to the extent permitted by
applicable law, regulation or stock exchange or national market system rule.

         12.07 Effective Date. The Plan shall become effective as of September
30, 1999. It shall continue in effect for a term of ten (10) years unless sooner
terminated under Section 12.05 hereof.

         12.08 No Employment Rights. The Plan does not, directly or indirectly,
create in any person any right with respect to continuation of employment by the
Company or any Subsidiary Corporation, and it shall not be deemed to interfere
in any way with the Company's or any Subsidiary Corporation's right to terminate
or otherwise modify any employee's employment at any time.

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         12.09 Effect of Plan. The provisions of the Plan shall, in accordance
with its terms, be binding upon and inure to the benefit of all successors of
each Employee participating in the Plan, including, without limitation, such
Employee's estate and the executors, administrators or trustees thereof, heirs
and legatees, and any receiver, trustee in bankruptcy or representative of
creditors of such Employee.

         12.10 Governing Law. The law of the State of North Carolina shall
govern all matters relating to this Plan except to the extent superseded by the
federal laws of the United States.

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