QUINTILES TRANSNATIONAL CORP
POS AM, 2000-08-21
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>   1

    As filed with the Securities and Exchange Commission on August 21, 2000
                                                      Registration No. 333-38181

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                ----------------

                         POST-EFFECTIVE AMENDMENT NO. 1
                                       TO
                                    FORM S-3
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                                ----------------

                          QUINTILES TRANSNATIONAL CORP.
             (Exact name of registrant as specified in its charter)

         NORTH CAROLINA                                   56-1714315
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
incorporation or organization)

                              4709 CREEKSTONE DRIVE
                         RIVERBIRCH BUILDING, SUITE 200
                        DURHAM, NORTH CAROLINA 27703-8411
                                 (919) 998-2000
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)

                            DENNIS B. GILLINGS, PH.D.
                      CHAIRMAN AND CHIEF EXECUTIVE OFFICER
                          QUINTILES TRANSNATIONAL CORP.
                              4709 CREEKSTONE DRIVE
                         RIVERBIRCH BUILDING, SUITE 200
                        DURHAM, NORTH CAROLINA 27703-8411
                                 (919) 998-2000
 (Name, address, including zip code, and telephone number, including area code,
                             of agent for service)

                                ----------------

                                   COPIES TO:

                              GERALD F. ROACH, ESQ.
                               AMY J. MEYERS, ESQ.
                            SMITH, ANDERSON, BLOUNT,
                      DORSETT, MITCHELL & JERNIGAN, L.L.P.
                         2500 First Union Capitol Center
                          Raleigh, North Carolina 27601
                                 (919) 821-1220

                          DEREGISTRATION OF SECURITIES

Quintiles Transnational Corp. (the "Company") registered 779,054 shares of its
common stock (the "Shares") pursuant to its Registration Statement on Form S-3
(File No. 333-38181) filed on October 17, 1997 and declared effective on October
21, 1997 (the "Registration Statement"). The Shares were registered to permit
resales of such Shares by certain Selling Shareholders named in the Registration
Statement. By filing this Post-Effective Amendment No. 1 to the Registration
Statement, the Company hereby removes from registration all of the Shares which
remain unsold as of the date hereof. The Registration Statement is hereby
amended, as appropriate, to reflect the deregistration of such Shares.



<PAGE>   2

                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-3 and has duly caused this
Post-Effective Amendment No. 1 to Registration Statement No. 333-38181 to be
signed on its behalf by the undersigned, thereunto duly authorized, in the City
of Durham, State of North Carolina, on August 21, 2000.

                                          QUINTILES TRANSNATIONAL CORP.


                                          By: /s/ Dennis B. Gillings
                                              ----------------------------------
                                              Dennis B. Gillings, Ph.D.
                                              Chairman of the Board of Directors
                                              and Chief Executive officer

<PAGE>   3

         Pursuant to the requirements of the Securities Act of 1933, this
Post-Effective Amendment No. 1 to Registration Statement No. 333-38181 has been
signed by the following persons as of August 21, 2000 in the capacities
indicated.

Signature                                Title
---------                                -----

/s/ Dennis B. Gillings                   Chairman of the Board of Directors
----------------------------------       and Chief Executive Officer
Dennis B. Gillings, Ph.D.

                *                        Vice Chairman and Director
----------------------------------
Santo J. Costa

/s/ James L. Bierman                     Chief Financial Officer
----------------------------------       (Principal accounting and financial
James L. Bierman                         officer)


                *                        Director
----------------------------------
Robert C. Bishop, Ph.D.

                                         Director
----------------------------------
E.G.F. Brown

                *                        Director
----------------------------------
Vaughn D. Bryson

                *                        Director
----------------------------------
Chester W. Douglass, Ph.D.

                                         Director
----------------------------------
Jim D. Kever

                *                        Director
----------------------------------
Arthur M. Pappas

                                         Director
----------------------------------
Eric J. Topol, M.D.

                                         Director
----------------------------------
Virginia V. Weldon, M.D.

* By: /s/ Dennis B. Gillings
      ----------------------------
      Dennis B. Gillings, Ph.D.



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