SUPERGEN INC
SC 13D, 1997-06-27
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549

                                 SCHEDULE 13D

                 UNDER THE SECURITIES EXCHANGE ACT OF 1934
                            (AMENDMENT NO.          )*
                                          ---------

                                    SuperGen, Inc.
           --------------------------------------------------------
                                (Name of Issuer)

                            Common Stock, $.001 par value
           --------------------------------------------------------
                          (Title of Class of Securities)

                                      868-059106
           --------------------------------------------------------
                                 (CUSIP Number)

                                    Rod J. Howard
                             Gray Cary Ware & Freidenrich
                              A Professional Corporation
                                 400 Hamilton Avenue
                               Palo Alto, CA 94301-3699
                                    (415) 328-6561
           --------------------------------------------------------
           (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)

                                    June 17, 1997
           --------------------------------------------------------
            (Date of Event which Requires Filing of this Statement)

If the  filing  person has  previously filed a  statement on Schedule 13G to
report the  acquisition  which  is the  subject  of this  Schedule 13D,  and is
filing this  schedule  because of Rule 13d-1(b)(3) or (4),  check the following
box / /.

Check the following box if a fee is being paid with this statement  / /.  (A
fee is not required only if the reporting person:  (1) has a previous statement
on file  reporting  beneficial ownership of more than five percent of the class
of securities  described in Item 1;  and  (2) has filed no amendment subsequent
thereto  reporting  beneficial ownership of five percent or less of such 
class.) (See Rule 13d-7.)

NOTE:  Six copies of this statement, including all exhibits, should be filed
with the Commission.  See Rule 13d-1(a) for other parties to whom copies are to
be sent.

*  The remainder of  this cover  page  shall  be  filled  out  for a reporting
person's  initial  filing on this  form with  respect to the  subject  class of
securities,  and for any  subsequent  amendment  containing  information  which
would alter disclosures provided in a prior cover page.

The information  required on the  remainder of this  cover page shall not be
deemed to be "filed"  for the purpose of  Section 18 of the Securities Exchange
Act of 1934  ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other  provisions of the Act  (however, see
the Notes).


SEC 1746 (12-91)


<PAGE>

CUSIP NO. 868-059106              SCHEDULE 13D             Page  2  of 12 Pages
- ---------------------                                     ----------------------


- -------------------------------------------------------------------------------
 (1) NAME OF REPORTING PERSON.
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

    Tako Ventures, LLC
- -------------------------------------------------------------------------------
 (2) CHECK THE APPROPRIATE BOX IF A MEMBER                       (a)  /X/
     OF A GROUP (See Instructions)                              (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC USE ONLY

- -------------------------------------------------------------------------------
 (4) SOURCE OF FUNDS*

    BK, WC
- -------------------------------------------------------------------------------
 (5) CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) or 2(e)

- -------------------------------------------------------------------------------
 (6) CITIZENSHIP OR PLACE OF ORGANIZATION

    California
- -------------------------------------------------------------------------------
      NUMBER OF          (7) SOLE VOTING POWER
       SHARES
    BENEFICIALLY
       OWNED                 3,825,000(1)
      BY EACH                --------------------------------------------------
     REPORTING           (8) SHARED VOTING POWER
      PERSON
       WITH                  --------------------------------------------------
                         (9) SOLE DISPOSITIVE POWER

                             3,825,000(1)
                             --------------------------------------------------
                        (10) SHARED DISPOSITIVE POWER

- -------------------------------------------------------------------------------
(11) AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     3,825,000(1)
- -------------------------------------------------------------------------------
(12) CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See Instructions)
     / /
- -------------------------------------------------------------------------------
(13) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     18%
- -------------------------------------------------------------------------------
(14) TYPE OF REPORTING PERSON (See Instructions)

    OO (Limited Liability Company)
- -------------------------------------------------------------------------------

                    *SEE INSTRUCTION BEFORE FILLING OUT!
            INCLUDES BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEMS 1-7
         (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION


<PAGE>

CUSIP NO. 868-059106              SCHEDULE 13D             Page  3  of 12 Pages
- ---------------------                                     ----------------------


- -------------------------------------------------------------------------------
 (1) NAME OF REPORTING PERSON.
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

    Lawrence J. Ellison
- -------------------------------------------------------------------------------
 (2) CHECK THE APPROPRIATE BOX IF A MEMBER                       (a)  /X/
     OF A GROUP (See Instructions)                              (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC USE ONLY

- -------------------------------------------------------------------------------
 (4) SOURCE OF FUNDS*

    BK
- -------------------------------------------------------------------------------
 (5) CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) or 2(e)

- -------------------------------------------------------------------------------
 (6) CITIZENSHIP OR PLACE OF ORGANIZATION

    U.S.A.
- -------------------------------------------------------------------------------
      NUMBER OF          (7) SOLE VOTING POWER
       SHARES            
    BENEFICIALLY
       OWNED                 3,825,000(1)
      BY EACH                --------------------------------------------------
     REPORTING           (8) SHARED VOTING POWER
      PERSON
       WITH                  --------------------------------------------------
                         (9) SOLE DISPOSITIVE POWER

                             3,825,000(1)
                             --------------------------------------------------
                        (10) SHARED DISPOSITIVE POWER

- -------------------------------------------------------------------------------
(11) AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     3,825,000(1)
- -------------------------------------------------------------------------------
(12) CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See Instructions)
     / /
- -------------------------------------------------------------------------------
(13) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     18%
- -------------------------------------------------------------------------------
(14) TYPE OF REPORTING PERSON (See Instructions)

    IN
- -------------------------------------------------------------------------------

<PAGE>

CUSIP NO. 868-059106              SCHEDULE 13D             Page  4  of 12 Pages
- ---------------------                                     ----------------------


- -------------------------------------------------------------------------------
 (1) NAME OF REPORTING PERSON.
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

    Cephalopod Corporation
- -------------------------------------------------------------------------------
 (2) CHECK THE APPROPRIATE BOX IF A MEMBER                       (a)  /X/
     OF A GROUP (See Instructions)                              (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC USE ONLY

- -------------------------------------------------------------------------------
 (4) SOURCE OF FUNDS*

    BK, WC
- -------------------------------------------------------------------------------
 (5) CHECK IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) or 2(e)

- -------------------------------------------------------------------------------
 (6) CITIZENSHIP OR PLACE OF ORGANIZATION

    California
- -------------------------------------------------------------------------------
      NUMBER OF          (7) SOLE VOTING
       SHARES                POWER
    BENEFICIALLY
       OWNED                 3,825,000(1)
      BY EACH                --------------------------------------------------
     REPORTING           (8) SHARED VOTING POWER
      PERSON
       WITH                  --------------------------------------------------
                         (9) SOLE DISPOSITIVE POWER

                             3,825,000(1)
                             --------------------------------------------------
                        (10) SHARED DISPOSITIVE POWER

- -------------------------------------------------------------------------------
(11) AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     3,825,000(1)
- -------------------------------------------------------------------------------
(12) CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See Instructions)
     / /
- -------------------------------------------------------------------------------
(13) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     18%
- -------------------------------------------------------------------------------
(14) TYPE OF REPORTING PERSON (See Instructions)

    CO
- -------------------------------------------------------------------------------

                    *SEE INSTRUCTION BEFORE FILLING OUT!
             INCLUDES BOTH SIDES OF THE COVER PAGE, REPONSES TO ITEMS 1-7
         (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION

<PAGE>

CUSIP NO. 868-059106              SCHEDULE 13D             Page  5  of 12 Pages
- ---------------------                                     ----------------------


- -------------------------------------------------------------------------------
 (1) NAMES OF REPORTING PERSONS.
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

    Lawrence Investments, LLC
- -------------------------------------------------------------------------------
 (2) CHECK THE APPROPRIATE BOX IF A MEMBER                       (a)  /X/
     OF A GROUP* (See Instructions)                              (b)  / /
- -------------------------------------------------------------------------------
 (3) SEC USE ONLY

- -------------------------------------------------------------------------------
 (4) SOURCE OF FUNDS*

    BK, WC
- -------------------------------------------------------------------------------
 (5) CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
     ITEMS 2(d) or 2(e)

- -------------------------------------------------------------------------------
 (6) CITIZENSHIP OR PLACE OF ORGANIZATION

    California
- -------------------------------------------------------------------------------
      NUMBER OF          (7) SOLE VOTING POWER
       SHARES           
    BENEFICIALLY
       OWNED                 3,825,000(1)
      BY EACH                --------------------------------------------------
     REPORTING           (8) SHARED VOTING POWER
      PERSON
       WITH                  --------------------------------------------------
                         (9) SOLE DISPOSITIVE POWER

                             3,825,000(1)
                             --------------------------------------------------
                        (10) SHARED DISPOSITIVE POWER

- -------------------------------------------------------------------------------
(11) AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     3,825,000(1)
- -------------------------------------------------------------------------------
(12) CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES
     (See Instructions)
     / /
- -------------------------------------------------------------------------------
(13) PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

     18%
- -------------------------------------------------------------------------------
(14) TYPE OF REPORTING PERSON (See Instructions)

    OO (Limited Liability Company)
- -------------------------------------------------------------------------------

                    *SEE INSTRUCTION BEFORE FILLING OUT!
             INCLUDES BOTH SIDES OF THE COVER PAGE, REPONSES TO ITEMS 1-7
         (INCLUDING EXHIBITS) OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION

<PAGE>

CUSIP NO. 868-059106              SCHEDULE 13D             Page  6  of 12 Pages
- ---------------------                                     ----------------------

(1) Pursuant to a Convertible Secured Note, Option and Warrant Purchase 
    Agreement (the "Agreement") dated as of June 17, 1997, Tako Ventures, 
    LLC ("Tako") has (or may acquire) the right to acquire up to 3,825,000 
    shares of Common Stock of SuperGen, Inc. ("Issuer") equal to 
    approximately 18% of the Common Stock of Issuer that would be 
    outstanding giving effect to such acquisition (based upon Issuer's 
    capitalization as of June 10, 1997).  Issuer's shares are issuable in 
    the manner summarized below (which summary is qualified in all respects 
    by reference to the Agreement and the exhibits thereto):

         (i)     1,700,000 shares of Issuer's Common Stock are issuable to Tako
                 upon conversion of a Convertible Secured Note in the 
                 principal amount of fifteen million three hundred thousand 
                 dollars ($15,300,000) which was issued to Tako by the Issuer 
                 on June 17, 1997.  The Convertible Secured Note will 
                 automatically be converted into shares of Common Stock (to 
                 the extent permitted under the Hart-Scott-Rodino Antitrust 
                 Improvements Act of 1976, as amended (the "Act")) on or 
                 before July 25, 1997, and any unconverted balance remaining 
                 will be converted upon the expiration or early termination 
                 of the waiting period under the Act (as long as no Material 
                 Adverse Effect (as defined in the Agreement) has occurred 
                 with respect to Issuer). Shares issued under the Convertible 
                 Secured Note will be issued at a conversion price of $9.00 
                 per share.

         (ii)    850,000 shares of Issuer's Common Stock are issuable to Tako
                 at a price of $9.00 per share pursuant to an Option, which was
                 issued to Tako by the Issuer on June 17, 1997.  Subject to
                 certain exceptions, the Option is exercisable at any time
                 prior to 5:00 p.m. (Pacific time) on January 31, 1998.

         (iii)   500,000 shares of Issuer's Common Stock are issuable to Tako
                 at a price of $13.50 per share pursuant to a nonredeemable
                 Warrant (the "Series 1 Warrant") which was issued to Tako by
                 the Issuer on June 17, 1997.  Subject to certain exceptions,
                 the Series 1 Warrant is exercisable at any time prior to 5:00
                 p.m. (Pacific time) on June 17, 2007.

         (iv)    350,000 shares of Issuer's Common Stock are issuable to Tako
                 at a price of $13.50 per share pursuant to a redeemable
                 Warrant (the "Series 2 Warrant") which was issued to Tako by
                 the Issuer on June 17, 1997.  The Series 2 Warrant is
                 exercisable at any time prior to 5:00 p.m. (Pacific time) on
                 June 17, 2007.

         (v)     Additional redeemable Warrants, which would allow Tako to
                 acquire up to 425,000 additional shares of Issuer's Common
                 Stock at a price of $13.50 per share, would be issued to Tako
                 if Tako exercises the Option described in clause (ii) in full
                 (the "Additional Series 2 Warrants").  Subject to certain
                 exceptions, the Additional Series 2 Warrants would be
                 exercisable at any time prior to 5:00 p.m. (Pacific time) on
                 June 17, 2007.


ITEM 1.  SECURITY AND ISSUER

    This Schedule 13D relates to the common stock, $.001 par value ("Common
Stock") of SuperGen, Inc., a California corporation (the "Issuer").  The
principal executive offices of the Issuer are located at Two Annabell Lane,
Suite 220, San Ramon, California 94583.

ITEM 2.  IDENTITY AND BACKGROUND.

<PAGE>


CUSIP NO. 868-059106              SCHEDULE 13D             Page  7  of 12 Pages
- ---------------------                                     ----------------------

    This statement is being filed jointly by:  (1) Tako Ventures, LLC, a
California limited liability company ("Tako"), (2) Cephalopod Corporation, a
California corporation ("Cephalopod"), (3) Lawrence Investments, LLC, a
California limited liability company ("Lawrence Investments"), and (4) Lawrence
J. Ellison, a natural person whose principal occupation is Chief Executive
Officer of Oracle Corporation.  Tako, Cephalopod, Lawrence Investments and
Lawrence J. Ellison will be collectively identified hereinafter as the
"Reporting Persons."  This Schedule 13D relates solely to, and is being filed
for, the investment by the Reporting Persons and does not relate to any
investment by Oracle Corporation or by Lawrence J. Ellison in his capacity as
Chief Executive Officer of Oracle Corporation.

    This Statement is based upon the Reporting Persons' direct and indirect
beneficial ownership of shares of Issuer.  The business address of Tako,
Cephalopod and Lawrence Investments is: c/o Howson & Simon CPAs, L.P., 220
Montgomery Street, Suite 1041, San Francisco, CA 94104.  The business address of
Lawrence J. Ellison is: c/o Oracle Corporation, 500 Oracle Parkway (Box 659525),
Redwood Shores, CA 94065.

    During the last five years, none of the Reporting Persons has been (a)
convicted in a criminal proceeding (excluding traffic violations or similar
misdemeanors) or (b) a party to a civil proceeding of a judicial or
administrative body of competent jurisdiction and as a result of such proceeding
was or is subject to a judgment, decree or final order enjoining future
violations of, or prohibiting or mandating activities subject to, federal or
state securities laws or finding any violation with respect to such laws.  Tako
and Lawrence Investments are organized in the state of California, Cephalopod is
incorporated in California and Lawrence J. Ellison is a citizen of the United
States of America and a resident of California.

ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION

    If the Convertible Secured Note is converted, Tako would acquire up to 
1,700,000 shares of Issuer's Common Stock at a conversion price of $9.00 per 
share.  The funds loaned to Issuer pursuant to the Convertible Secured Note 
were obtained by Tako as working capital from funds ultimately obtained by 
Lawrence J. Ellison under a revolving line of credit provided to him by a 
bank. That line of credit charges interest on rates based on a spread over 
LIBOR, and is currently due for repayment at the end of February, 1998.

    In addition, Tako may acquire (i) 850,000 shares of Common Stock at $9.00 
per share upon the exercise of the Option, (ii) 500,000 shares of Common 
Stock at $13.50 per share upon the exercise of the Series 1 Warrants, (iii) 
350,000 shares of Common Stock at $13.50 per share upon the exercise of the 
Series 2 Warrants, and (iv) Additional Series 2 Warrants, which would allow 
Tako to acquire up to 425,000 additional shares of Issuer's Common Stock at a 
price of $13.50 per share to be issued to Tako if Tako exercises the Option 
described in clause (i) in full.  It is presently anticipated that any 
purchases of the Issuer's Common Stock resulting from the exercise of the 
Option or the Series 1, Series 2, or Additional Series 2 Warrants (the Series 
1 Warrants, Series 2 Warrants and Additional Series 2 Warrants are 
collectively referred to as the "Warrants" hereinafter) under the 
circumstances specified in the Agreement may be funded by one or more of the 
following: working capital or borrowings of Tako, Cephalopod, Lawrence 
Investments, or Lawrence J. Ellison.

ITEM 4.  PURPOSE OF TRANSACTION

    The Reporting Persons entered into the Agreement with Issuer for 
investment purposes and for the purpose of obtaining representation on the 
Issuer's Board of Directors.  Pursuant to the Agreement and subject to the 
conditions therein and so long as Tako owns not less than 850,000 shares of 
Common Stock, the Board of Directors of the Issuer shall nominate and 
recommend a representative of Tako designated by Tako and deemed reasonably 
acceptable to Issuer (the "Purchaser Representative") for election as a 
Director of the

<PAGE>


CUSIP NO. 868-059106              SCHEDULE 13D             Page  8  of 12 Pages
- ---------------------                                     ----------------------

Issuer, and shall otherwise use its reasonable best efforts to cause the 
election of such Purchaser Representative as a Director of the Issuer at each 
meeting of the Issuer's shareholders at which the Purchaser Representative's 
term as a Director would otherwise expire.  The Agreement designates Lawrence 
J. Ellison as the first Purchaser Representative.  In accordance with the 
Agreement, Issuer as of June 18, 1997 increased the number of directors 
allowed to serve on the Board of Directors by one member.  In addition, 
pursuant to the Agreement and subject to the conditions therein and so long 
as Tako owns not less than 850,000 shares of Common Stock, Tako shall be 
entitled to designate one individual who shall receive notice of all meetings 
of the Board of Directors and the Executive Committee of the Issuer and who 
shall be entitled to attend and participate in all such meetings as an 
observer on behalf of Tako.

    The Issuer's outstanding Common Stock would increase by 3,825,000 shares in
the event of conversion of the Convertible Secured Note and in the event of the
exercise of the Option and the Warrants.

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER

    The Reporting Persons are deemed to have beneficial ownership, as defined 
in Rule 13d-3(a), of an aggregate of 3,825,000 shares of the Issuer's Common 
Stock, which would represent approximately 18% of the Common Stock that would 
be outstanding in the event of conversion in full of the Convertible Secured 
Note, and exercise in full of the Option and Warrants.  Upon exercise of the 
Convertible Secured Note, Option and Warrants, the Reporting Persons would 
have sole voting and dispositive power over Common Stock acquired upon such 
exercise.

ITEM 6.  CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT
         TO SECURITIES OF THE ISSUER

    Lawrence J. Ellison is the sole shareholder of Cephalopod and a member of 
Lawrence Investments.  Cephalopod and Lawrence Investments are the sole 
members of Tako.

         Under the Agreement, Tako may acquire shares of Common Stock, 
Options and Warrants, and shares of Common Stock issuable upon exercise of 
such Options and Warrants, as described in Item 3 and footnote 1.  The 
Agreement also contains a standstill provision, a pre-emption right, and 
certain restrictions on Tako's ability to transfer the Common Stock that it 
may acquire as described below:

    (a)  The standstill provides that neither Tako nor Lawrence J. Ellison may
    acquire either directly or indirectly, agree to acquire, or make a tender
    or exchange offer to acquire, any shares of voting capital stock, any
    securities convertible into or exchangeable for voting capital stock, or
    any other right to acquire voting capital of the Issuer ("Voting Stock"),
    unless (a) such Voting Stock is acquired for investment purposes only and
    not with a view to any change in control of the Issuer; and (b) following
    such acquisition, Tako, Lawrence J. Ellison, and its and his majority-owned
    and controlled affiliates will beneficially own, in the aggregate, not more
    than twenty five percent (25%) of the Company's Common Stock issued and
    outstanding or issuable upon exercise, conversion or exchange of all
    outstanding options, warrants and other convertible securities of the
    Company.

    (b)  Under the pre-emption right, prior to any sale or issuance by the
    Company of any shares of capital stock of the Company or any security
    exercisable for or convertible into such capital stock ("Capital Stock"),
    Tako shall have the right to purchase a portion of such Capital Stock on
    terms which, subject to certain conditions, are at least as favorable to
    Tako as the terms on which the Issuer is willing and proposes to sell such
    Capital Stock to other prospective investors.  The

<PAGE>

CUSIP NO. 868-059106            SCHEDULE 13D                 PAGE 9 OF 12 PAGES
- --------------------                                         ------------------

    amount of Capital Stock which Tako is entitled to acquire shall be equal to
    (i) the amount of Capital Stock proposed to be sold or issued by the Issuer
    multiplied by (ii) a fraction calculated by dividing (A) the number of 
    shares of Common Stock owned by Tako or issued and issuable upon 
    exercise conversion or exchange of the Convertible Secured Note and all 
    Warrants, Options and other securities of the Issuer held by Tako as of 
    the date that Issuer gives notice to Tako of such intention to sell and 
    issue such Capital Stock (the "Notice Date") by (B) the total number of 
    shares of Common Stock issued and outstanding or issuable upon exercise, 
    conversion or exchange of all outstanding options, warrants and other 
    convertible securities of the Issuer as of the Notice Date. 
    Notwithstanding the foregoing, in no event shall Tako be entitled to 
    purchase Capital Stock in excess of the limitations on ownership of 
    Voting Stock described.

    (c)  For a period of up to five (5) years, Tako shall not, directly or 
    indirectly, sell or transfer any Voting Stock unless permitted by, and 
    subject to the terms of, the Agreement. Permissible transfers or sales 
    by Tako include but are not limited to transfers or sales (i) to the 
    Issuer or any person or group approved by the Issuer, (ii) to any entity 
    of which Lawrence J. Ellison owns securities representing not less than 
    a majority, (iii) pursuant to certain corporate transactions, or (iv) in 
    other transactions not otherwise described in the Agreement as long as 
    Tako reasonably believes that such transactions will not, directly or 
    indirectly, result in a single person or group acquiring beneficial 
    ownership of Voting Stock with aggregate voting power of five percent 
    (5%) or more of the total Voting Stock of the Issuer then outstanding. A 
    more detailed description of the terms and conditions of the transfer 
    restrictions is set forth in Section 5.10(a) of the Agreement. In 
    addition, Issuer has certain rights of first refusal to purchase all or 
    part of the Voting Stock of Tako proposed to be sold or transferred 
    under conditions described in Section 5.10(a) of the Agreement.

    Pursuant to the Agreement, Issuer has issued to Tako a Convertible 
Secured Promissory Note by which the Issuer promises to pay Tako up to 
fifteen million three hundred thousand dollars ($15,300,000) (the "Principal 
Amount") upon certain conditions.  In accordance with the Agreement and the 
Convertible Secured Promissory Note and at Tako's election prior to the 
Conversion Time (as defined below), the Principal Amount of the Convertible 
Secured Note shall be immediately due and payable by Issuer to Tako.  The 
Conversion Time shall be no later than July 25, 1997 and may occur earlier if 
certain contingencies described in Section 1.1 of the Agreement are 
satisfied.  In the absence of such an election by Tako and in accordance with 
the Agreement, the Convertible Secured Note shall be automatically converted 
into shares of the Issuer's Common Stock at a conversion price of $9.00 per 
share (subject to certain adjustments).

    Pursuant to the Agreement, certain officers of the Issuer have entered into
a Shareholder Agreement restricting, prior to 11:59 p.m. October 31, 1998, the
sale, exchange, transfer, pledge, distribution or other disposition of, or grant
of any option with respect to, establishment of any "short" or put-equivalent
position with respect to, or otherwise enter into any Agreement, arrangement,
transaction or series of transactions which has or is intended to have the
effect, directly or indirectly, of reducing the Officer's risk of ownership in
more than fifteen percent (15%) of the shares of Issuer's Common Stock owned
beneficially or of record, or repurchasable by Shareholder pursuant to options,
warrants and other securities outstanding, as of the date of the Shareholder
Agreement.

    Pursuant to the Agreement, certain large shareholders of the Issuer have
entered into a Shareholder Agreement restricting, prior to 11:59 p.m. October
31, 1998, the sale, exchange, transfer, pledge, distribution or other
disposition of, or grant of any option with respect to, establish any "short" or
put-equivalent position with respect to, or otherwise enter into any agreement,
arrangement, transaction or series of transactions which has or is intended to
have the effect, directly or indirectly, of reducing such signatory's risk of
ownership in more than three hundred fifty thousand (350,000) of the shares of
Issuer's Common Stock owned beneficially or of record, or purchasable by
Shareholder pursuant to options, warrants and other securities outstanding, as
of the date of the Shareholder's Agreement.

    Pursuant to the Agreement, Issuer has agreed to indemnify Mr. Ellison for
certain liabilities in connection with the transactions contemplated by the
Agreement.

<PAGE>

CUSIP NO. 868-059106              SCHEDULE 13D             PAGE 10 OF 12 PAGES
- ---------------------                                     ----------------------

ITEM 7.  MATERIAL TO BE FILED AS EXHIBITS

EXHIBIT NO.      DESCRIPTION

1.                    Convertible Secured Note, Option and Warrant Agreement

2.                    Convertible Secured Promissory Note

3.                    Series 1 Warrant

4.                    Series 2 Warrant

5.                    Pledge and Security Agreement

6.                    Shareholders Agreement (Exhibit F to the Agreement)

7.                    Shareholders Agreement (Exhibit G to the Agreement)

8.                    Joint Filing Agreement among the Reporting Parties


<PAGE>

CUSIP NO. 868-059106              SCHEDULE 13D             PAGE 11 OF 12 PAGES
- ---------------------                                     ----------------------

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.


Dated:  June 27, 1997
        --------------------------------


TAKO VENTURES, LLC                          CEPHALOPOD CORPORATION

                                            /s/ Philip B. Simon
                                            --------------------------
By:      Cephalopod Corporation             By:  Philip B. Simon
                                            Its: President
         By:  /s/ Philip B. Simon
              --------------------------
                Name:  Philip B. Simon
                Title: President



LAWRENCE INVESTMENTS, LLC


/s/ Philip B. Simon                         /s/ Lawrence J. Ellison
- ----------------------------------------    --------------------------
By:  Philip B. Simon                        Lawrence J. Ellison
Its: Member

<PAGE>

- --------------------------------------------------------------------------------

                           CONVERTIBLE SECURED NOTE, OPTION

                                     AND WARRANT

                                  PURCHASE AGREEMENT

                                     by and among

                                   SUPERGEN, INC.,

                              a California corporation,

                                 TAKO VENTURES, LLC,

                       a California limited liability company,

                                         and,

                     solely for purposes of Sections 5.3 and 5.5,

                                 LAWRENCE J. ELLISON,

                              dated as of June 17, 1997


<PAGE>

                                  TABLE OF CONTENTS
                                                                            Page
                                                                            ----
ARTICLE I     SALE AND PURCHASE OF SECURITIES...............................  1

Section 1.    Sale and Purchase of Securities...............................   1
        1.1   Conversion of Convertible Secured Note........................   2
        1.2   Conversion Price and Exercise Price...........................   3
        1.3   Certain Adjustments...........................................   6
        1.4   No Future Funding Commitment or Obligation....................   8

ARTICLE II    CLOSING AND EXERCISE PROCEDURES...............................   9

Section 2.    Closing Dates; Delivery.......................................   9
        2.1   Purchase of the Convertible Secured Note......................   9
        2.2   Option Closings; Exercise of the Option.......................   9

ARTICLE III   REPRESENTATIONS AND WARRANTIES OF THE COMPANY.................   9

Section 3.    Representations and Warranties of the Company.................   9
        3.1   Organization, Standing and Power; Qualification...............  10
        3.2   Subsidiaries..................................................  10
        3.3   Capitalization................................................  10
        3.4   Authority; No Conflicts; Approvals............................  11
        3.5   Financial Statements..........................................  12
        3.6   Absence of Undisclosed Liabilities............................  12
        3.7   Absence of Certain Changes or Events..........................  13
        3.8   Taxes.........................................................  14
        3.9   Tangible Assets and Real Property.............................  15
        3.10  Intellectual Property.........................................  15
        3.11  Product Liability.............................................  17
        3.12  Contracts.....................................................  17
        3.13  Environmental Matters.........................................  18
        3.14  SEC Reports...................................................  18
        3.15  Employee Benefit Plans........................................  19
        3.16  Employees.....................................................  19
        3.17  Interested Party Transactions.................................  20
        3.18  Brokers or Finders............................................  20
        3.19  Compliance with Laws..........................................  20
        3.20  Litigation....................................................  20
        3.21  Restrictions on Business Activities...........................  20
        3.22  No Misrepresentation..........................................  21

                                          i

<PAGE>

ARTICLE IV    REPRESENTATIONS AND WARRANTIES OF PURCHASER...................  21

Section 4.    Representations and Warranties of Purchaser...................  21
        4.1   Organization..................................................  21
        4.2   Authority.....................................................  21
        4.3   Acquisition for Investment....................................  22
        4.4   Brokers or Finders............................................  23

ARTICLE V     ADDITIONAL AGREEMENTS.........................................  24

Section 5.    Additional Agreements.........................................  24
        5.1   Pre-Emption Right with Respect to Company Offerings...........  25
        5.2   Stock Plans...................................................  25
        5.3   Board Representation..........................................  27
        5.4   Certain Agreements of Directors, Officers and Key Employees of
              the Company...................................................  27
        5.5   Standstill Provisions.........................................  27
        5.6   Financial Statements and Other Reports........................  28
        5.7   Confidentiality.  ............................................  29
        5.8   Public Announcements..........................................  29
        5.9   HSR Act.......................................................  29
        5.10  Certain Restrictions..........................................  30
        5.11  Legends.......................................................  33
        5.12  Indemnification...............................................  34
        5.13  Further Assurances.  .........................................  35

ARTICLE VI    REGISTRATION RIGHTS...........................................  36

Section 6.    Registration Rights...........................................  36
        6.1   Definitions...................................................  36
        6.2   Request for Registration......................................  36
        6.3   Company Registration..........................................  38
        6.4   Form S-3......................................................  39
        6.5   Obligations of the Company....................................  39
        6.6   Provision of Information......................................  41
        6.7   Expenses of Demand Registration...............................  41
        6.8   Expenses of Company Registration..............................  41
        6.9   Delay of Registration.........................................  41
        6.10  Indemnification...............................................  41
        6.11  Reports Under the Exchange Act................................  43
        6.12  Assignment of Registration Rights.............................  44
        6.13  "Market Stand-Off" Agreement..................................  44
        6.14  Termination of Registration Rights............................  44
        6.15  No Inconsistent Agreements....................................  44

                                          ii

<PAGE>

ARTICLE VII   CONDITIONS TO CLOSINGS........................................  45

Section 7.    Conditions to Closing.........................................  45
        7.1   Conditions to Purchaser's Obligation to Acquire the Convertible
              Secured Note.  ...............................................  45
        7.2   Conditions to Company's Obligation to Issue the Convertible
              Secured Note..................................................  46
        7.3   Conditions to Issuance of Option Common.......................  46

ARTICLE VIII  MISCELLANEOUS.................................................  47

Section 8.    Miscellaneous.................................................  47
        8.1   Access to Information.........................................  47
        8.2   Waivers and Amendments........................................  47
        8.3   Governing Law.................................................  47
        8.4   Survival......................................................  47
        8.5   Successors and Assigns........................................  48
        8.6   Entire Agreement..............................................  48
        8.7   Notices.......................................................  48
        8.8   Severability..................................................  48
        8.9   Expenses......................................................  48
        8.10  Interpretation................................................  49
        8.11  Counterparts..................................................  49
        8.12  Delays or Omissions...........................................  49

Exhibit A - Convertible Secured Promissory Note
Exhibit B - Series 1 Warrant
Exhibit C - Series 2 Warrant
Exhibit D - Pledge and Security Agreement
Exhibit E - Confidentiality Agreement
Exhibit F - Shareholder Agreement
Exhibit G - Shareholder Agreement
Exhibit H - Opinion of Wilson Sonsini Goodrich & Rosati, Professional
            Corporation

                                         iii

<PAGE>

                         CONVERTIBLE SECURED NOTE, OPTION AND
                              WARRANT PURCHASE AGREEMENT


    THIS CONVERTIBLE SECURED NOTE, OPTION AND WARRANT PURCHASE AGREEMENT (the
"AGREEMENT") is made as of June 17, 1997 by and among SUPERGEN, INC., a
California corporation (the "COMPANY"), TAKO VENTURES, LLC, a California limited
liability company ("PURCHASER"), and, solely for purposes of Sections 5.3
and 5.5, LAWRENCE J. ELLISON ("ELLISON").

    WHEREAS, Purchaser wishes to purchase, and the Company wishes to sell,
certain securities convertible into or exercisable for shares of the Company's
common stock, par value $.001 per share ("COMMON STOCK");

    NOW, THEREFORE, in consideration of the mutual promises, covenants and
conditions hereinafter set forth, the parties hereby agree as follows:

                                      ARTICLE I
                           SALE AND PURCHASE OF SECURITIES

    1.     SALE AND PURCHASE OF SECURITIES.  On the terms and subject
to the conditions set forth in this Agreement, the Company will issue and sell
to Purchaser, and Purchaser will purchase:

              (a)  a convertible secured promissory note (the "CONVERTIBLE
SECURED NOTE") in the principal amount of fifteen million three hundred thousand
dollars ($15,300,000) (the "PRINCIPAL AMOUNT"), in the form annexed hereto as
EXHIBIT A;

              (b)  an option to purchase (the "OPTION"), exercisable at any
time or from time to time prior to the earlier of the date of the Notice of
Demand (as defined in Section 1.1) and 5:00 p.m. Pacific Standard Time on
January 31, 1998 (the "OPTION TERMINATION DATE"), in whole or in part, eight
hundred fifty thousand (850,000) shares of Common Stock (such number to be
adjusted pursuant to Section 1.3) (shares purchased pursuant to the Option are
hereinafter referred to as the "OPTION COMMON"); and

              (c)  warrants to purchase (the "WARRANTS"), at any time or from
time to time, prior to the earlier of the date of the Notice of Demand (as
defined in Section 1.1) and the tenth anniversary of the date of this Agreement,
in whole or in part, a number of shares of Common Stock equal to one-half the
sum of (i) the Option Common and (ii) the shares of Common Stock issued upon
conversion in full of the Convertible Secured Note (subject, in each case, to
adjustment in accordance with Sections 1.2(b) and 1.3 of this Agreement, and
subject further to the provisions of Section 2.1(b) which shall govern the
number and series of Warrants issued to Purchaser at the Note Closing).
Warrants to purchase 500,000 shares of Common Stock shall be denominated as
Series 1 Warrants (the "SERIES 1 WARRANTS") and shall have the

                                          iv

<PAGE>

rights set forth in the form of Series 1 Warrant attached hereto as EXHIBIT B,
and the remaining Warrants shall be denominated as Series 2 Warrants (the
"SERIES 2 WARRANTS") and shall have the rights set forth in the form of Series 2
Warrant attached hereto as EXHIBIT C.

         1.1  CONVERSION OF CONVERTIBLE SECURED NOTE.  At Purchaser's election,
upon delivery to the Company of a written notice of demand for repayment (a
"NOTICE OF DEMAND") in accordance with the provisions of Section 8.7 at any time
prior to 5:00 p.m. Pacific Daylight Savings Time on the earlier of (i) July 25,
1997 and (ii) the execution and delivery of a definitive transaction agreement
to the effect described in the letter of Purchaser to the Company of even date
herewith (the "TRIGGER TRANSACTION"), the principal terms of which having been
timely communicated by the Company to Purchaser as provided in Section 1.1(a)
(the "CONVERSION TIME"), the Principal Amount of the Convertible Secured Note
shall be immediately due and payable by the Company to Purchaser, in full,
without interest, and shall be paid by the Company by wire transfer of
immediately available funds, to the account specified by Purchaser in the Notice
of Demand, on the next business day after delivery of the Notice of Demand.  In
the absence of a Notice of Demand delivered within the applicable time period,
(a) the Convertible Secured Note shall automatically be converted, to the
maximum extent permitted under the Hart-Scott-Rodino Antitrust Improvements Act
of 1976, as amended (the "HSR ACT") and any other applicable laws, effective at
the Conversion Time, into a number of shares of Common Stock equal to the
quotient of the Principal Amount divided by the Conversion Price (as hereinafter
defined), rounded up to the nearest whole share and adjusted as provided in
Sections 1.2(b) and 1.3; (b) a certificate for such shares of Common Stock shall
forthwith be issued to Purchaser upon surrender of the Convertible Secured Note
to the Company for cancellation (and, in the event of a partial conversion,
reissuance of a replacement note in the same form in the applicable new
principal amount); and (c) any unconverted portion of the Convertible Secured
Note shall remain outstanding, without interest, until the expiration or early
termination of the applicable waiting periods under the HSR Act and the receipt
of any other required approvals under any other applicable laws (the "SECOND
CONVERSION TIME"), at which time such unconverted portion shall automatically be
converted into shares of Common Stock consistent with the provisions of clause
(a) of this Section 1.1, and a certificate therefor shall be issued to Purchaser
in accordance with the provisions of clause (b) of this Section 1.1, unless a
Material Adverse Effect (as defined in Section 3.1) shall have occurred at or
prior to the Second Conversion Time or there shall exist at the Second
Conversion Time any fact or circumstance which would reasonably be expected to
result in a Material Adverse Effect, in which event the Company shall so notify
Purchaser and the remaining unconverted portion of the Convertible Secured Note
shall not be converted into shares of Common Stock, but, at Purchaser's
election, shall be surrendered to the Company for cancellation and
simultaneously with such surrender the then-outstanding principal amount thereof
shall be repaid by the Company to Purchaser by wire transfer of immediately
available funds to an account designated by Purchaser.  In the event that any
portion of the Convertible Secured Note shall remain unconverted on the Option
Termination Date because the applicable waiting period(s) under the HSR Act have
not expired or been terminated or required approvals under applicable laws have
not been received, the Convertible Secured Note (or any replacement note issued
pursuant to this Section 1.1) shall be surrendered to the Company for
cancellation promptly following the Option Termination Date, and simultaneously
with such surrender the then-outstanding principal amount thereof shall be
repaid by the Company to Purchaser by wire


                                          2
<PAGE>

transfer of immediately available funds to an account designated by Purchaser.
Upon such cancellation, conversion in full or repayment, the Company shall have
no further obligations to Purchaser pursuant to the Convertible Secured Note and
any replacement note issued pursuant to this Section 1.1.  The Common Stock
issuable upon conversion of the Convertible Secured Note is hereinafter referred
to as the "INITIAL COMMON".

         (a)  TRIGGER TRANSACTION:  The principal terms of the proposed Trigger
Transaction shall be communicated by the Company to Purchaser not less than
twenty four (24) hours prior to the execution and delivery of a definitive
agreement with respect to such Trigger Transaction.  Such communication may be
made in any reasonable manner, including telephonically.  No Notice of Demand
shall be given after the execution and delivery of a definitive transaction
agreement providing for a Trigger Transaction, and no Notice of Demand given
after the execution and delivery of a definitive transaction agreement providing
for a Trigger Transaction shall have any force or effect.

         1.2  CONVERSION PRICE AND EXERCISE PRICES.

              (a)  Subject in each case to adjustment in accordance with the
provisions of Sections 1.2(b) and 1.3, the conversion price for each share of
Initial Common shall be nine dollars ($9.00) per share (the "CONVERSION PRICE").
Subject to adjustment in accordance with the provisions of Section 1.3, the
purchase price for each share of Common Stock purchased upon exercise of the
Option shall be nine dollars ($9.00) (the "OPTION EXERCISE PRICE").  Subject to
adjustment in accordance with the applicable provisions of this Agreement and
the terms of the Warrants, the purchase price for each share of Common Stock
purchased upon exercise of any of the Warrants shall be thirteen dollars fifty
cents ($13.50) per share (the "WARRANT EXERCISE PRICE").

              (b)  Subject to the limitations set forth in Section 1.2(c), if
at any time or from time to time during the two-year period immediately
following the Note Closing Date (as defined below) the Company shall sell or
issue shares of Common Stock, or if the Company shall agree in such two-year
period to sell or issue shares of Common Stock and thereafter shall sell any
shares of Common Stock pursuant to such agreement either within such two-year
period or at any time in the six months immediately following such two-year
period, to any person other than Purchaser or a majority-owned and controlled
affiliate of Purchaser at a price less than nine dollars ($9.00) per share (as
the same may be adjusted from time to time pursuant to Section 1.3) (each such
price, a "LESSER PRICE"; the shares sold at such Lesser Price, the "LESSER PRICE
SHARES"; and the number of shares sold at each such Lesser Price, the "LESSER
PRICE SHARE NUMBER"), then (i) the Conversion Price for a number of shares of
Initial Common equal to the applicable Lesser Price Shares Number shall be
reduced to the applicable Lesser Price; (ii) the aggregate number of shares of
Initial Common issuable upon conversion of the Convertible Secured Note shall
thereupon automatically be increased to reflect such reduction in the Conversion
Price (and additional shares of Initial Common shall forthwith be issued to
Purchaser if the Convertible Secured Note shall already have been converted
either in whole or in part into Initial Common); and (iii) the Warrant Exercise
Price for a number of shares of Common Stock equal to one-half the applicable
Lesser Price Share Number shall thereupon automatically be reduced so as to
equal 150% of such Lesser Price (and additional shares of Common Stock shall
forthwith be issued to


                                          3
<PAGE>

the Warrant holder to the extent that any Warrant shall theretofore have been
exercised); PROVIDED, that, if the cumulative number of shares of Company Common
Stock sold or issued (or agreed to be sold or issued) by the Company at any
Lesser Price during such two-year period shall exceed 50% of the number of
shares of Initial Common issuable upon conversion in full of the Convertible
Secured Note (without giving effect to the provisions of this Section 1.2(b)),
then (A) the Conversion Price for all shares of Common Stock issuable (or
therefore issued) pursuant to the Convertible Secured Note shall thereupon
automatically be reduced so as to equal the weighted average of such Lesser
Prices relating to all of such Lesser Price Shares (the "WEIGHTED AVERAGE
PRICE"); (B) the aggregate number of shares of Initial Common issuable upon
conversion of the Convertible Secured Note shall be thereupon automatically be
increased to reflect such reduction in the Conversion Price (and additional
shares of Initial Common shall forthwith be issued to Purchaser if the
Convertible Secured Note shall already have been converted either in whole or in
part into Initial Common); (C) the Warrant Exercise Price for all shares of
Common Stock purchasable (or theretofore purchased) pursuant to the Warrants
shall thereupon automatically be reduced so as to equal 150% of such Weighted
Average Price (and additional shares of Common Stock shall forthwith be issued
to the Warrant holder to the extent that any Warrant shall theretofore have been
exercised); and (D) the Option Exercise Price for all shares of Option Common
theretofore purchased pursuant to the Option shall be reduced to such Weighted
Average Price and additional shares of Option Common shall forthwith be issued
to Purchaser.  The provisions of clauses (A) and (B) of this Section 1.2(b)
shall be applicable to all shares of Common Stock issued or issuable pursuant to
the Convertible Secured Note, and the provisions of clause (C) of this
Section 1.2(b) shall be applicable to all shares of Common Stock issued or
issuable pursuant to the Warrants, in each case including shares previously
adjusted pursuant to clauses (i), (ii) or (iii) of this Section 1.2(b).  In the
event of successive sales or issuances of Common Stock at Lesser Prices,
(X) successive adjustments shall be made to the Conversion Price and the Warrant
Exercise Price pursuant to clauses (i) through (iii) of this Section 1.2(b), and
each successive adjustment pursuant to such clauses (i) through (iii) shall be
applied to shares that have not previously been adjusted pursuant to such
clauses, and (Y) successive adjustments may be made to the Weighted Average
Price and may either increase or decrease any previously applicable Weighted
Average Price, but no adjustment to the Weighted Average Price, the Conversion
Price or the Warrant Exercise Price under any provision of this Section 1.2(b)
shall be applied so as to require the cancellation or return by Purchaser of any
shares of Common Stock theretofore issued to Purchaser or otherwise to affect
Purchaser's entitlement to and retention of such previously issued shares.  No
adjustment pursuant to clauses (i) through (iii) of this Section 1.2(b) shall be
applied so as to increase the Conversion Price or the Warrant Exercise Price
with respect to any shares of Common Stock covered by the Convertible Secured
Note or the Warrants; no adjustment under any provision of this Section 1.2(b)
shall be applied so as to increase the Option Exercise Price; and in no event
shall any cash refund be paid to Purchaser pursuant to any adjustment of the
Conversion Price, the Option Exercise Price or the Warrant Exercise Price
pursuant to this Section 1.2(b).  The Company shall notify Purchaser of each
sale or issuance of, and each agreement to sell or issue, Common Stock at a
Lesser Price within five business days after the consummation of such sale or
the execution of such agreement.

              (c)  Notwithstanding any other provision of this Agreement,
Section 1.2(b) shall not apply to the following sales and issuances of Common
Stock:


                                          4
<PAGE>

         (i)  Common Stock issued to employees, officers, directors and
    consultants pursuant to any stock option plan, stock inventive or purchase
    plan or agreement approved by the Board of Directors of the Company,
    subject to the limitations set forth in Section 5.2;

         (ii) Common Stock issued pursuant to or upon exercise or conversion of
    securities issued in connection with a merger, consolidation, share
    exchange, or other reorganization or business combination, approved by Tako
    (whose approval shall not be unreasonably withheld), involving the Company,
    in which the Company is the acquiring corporation or shareholders of the
    Company immediately prior to such merger, consolidation or other
    reorganization or business combination own securities with a majority of
    the voting power of the resulting entity (including, but not limited to,
    the proposed merger of the Company into a wholly-owned Delaware subsidiary
    of the Company in connection with a proposed reincorporation of the Company
    in Delaware, on the terms set forth in the Company's proxy statement dated
    April 25, 1997);

         (iii)     Common Stock, in an aggregate amount up to five percent (5%)
    of the Company's outstanding Common Stock as of the date hereof, issued
    pursuant to or upon exercise or conversion of securities issued in
    connection with (A) any equipment financing in an amount in excess of
    $250,000 or (B) any technology licensings, drug product licensings,
    research or development agreements or asset acquisitions approved by the
    Board of Directors;

         (iv) Common Stock issued upon exercise of securities issued pursuant
    to rights distributed to holders of Common Stock generally;

         (v)  Common Stock issued in connection with any stock split, stock
    dividend or recapitalization of the Company;

         (vi) Common Stock issued upon conversion of Company Preferred Stock;
    and

         (vii)     Common Stock issued pursuant to the exercise of any stock
    options or warrants or any other rights to acquire shares of Common Stock
    (including, but not limited to, the warrants issued in connection with the
    Company's initial public offering) outstanding on the date hereof.

Notwithstanding any other provision of this Agreement, the provisions set forth
in Section 1.2(b) shall terminate upon the earlier of:  (i) the Company's sale
of all or substantially all of its assets, (ii) a merger, consolidation, share
exchange, or other reorganization or business combination involving the Company
in which the Company is not the surviving corporation or shareholders of the
Company immediately prior to such merger, consolidation, share exchange or other
reorganization or business combination own less than fifty percent (50%) of the
voting capital stock of  the resulting entity or (iii) the second anniversary of
the Note Closing.


                                          5
<PAGE>

         1.3  CERTAIN ADJUSTMENTS.  The following adjustments shall apply to
the then-unconverted portion (if any) of the Convertible Secured Note and the
then-unexercised portion (if any) of the Option.

              (a)  In the event that the Company shall (i) pay a dividend in,
or make a distribution of, shares of capital stock or other securities
(including, without limitation, any rights or options to subscribe to or
purchase any additional shares of any class of its capital stock, any evidence
of its indebtedness or assets, or any other rights or options) on its
outstanding Common Stock, (ii) subdivide its outstanding shares of Common Stock
into a greater number of such shares or (iii) combine its outstanding shares of
Common Stock into a smaller number of such shares, the total number of shares of
Common Stock purchasable pursuant to the Option and the total number of shares
issuable upon conversion of the Convertible Secured Note shall be adjusted so
that Purchaser shall be entitled to receive at the same aggregate Conversion
Price and Option Exercise Price the number of shares of capital stock and other
securities (of one or more classes) which Purchaser would have owned or would
have been entitled to receive immediately following the happening of any of the
events described above had Purchaser acquired all shares of Common Stock
purchasable under the then-unexercised portion of the Option and issuable upon
conversion of the then-unconverted portion of the Convertible Secured Note, in
full, immediately prior to the record date with respect to such event.  Any
adjustment made pursuant to this Section 1.3(a) shall, in the case of a dividend
or distribution of Common Stock or other securities of the Company, become
effective as of the record date therefor and, in the case of a subdivision or
combination, be made as of the effective date thereof.  If, as a result of an
adjustment made pursuant to this Section 1.3(a), Purchaser shall become entitled
to receive shares or other units of two or more classes of capital stock or
other securities of the Company upon a subsequent conversion under the
Convertible Secured Note or a subsequent exercise of purchase rights under the
Option, the Board of Directors of the Company (whose reasonable determination
shall be conclusive and, upon request by Purchaser, shall be evidenced by a
certified Board resolution delivered to Purchaser) shall determine the
allocation of the adjusted purchase price or exercise price between or among
shares of such classes of capital stock.

              (b)  In the event of a capital reorganization or a
reclassification of the Common Stock (except as provided in Section 1.3(a) above
or Section 1.3(c) below), Purchaser shall be entitled to receive, in
substitution for the Common Stock to which Purchaser would have become entitled
upon exercise immediately prior to such reorganization or reclassification, the
shares (of any class or classes) or other securities or property of the Company
(or cash) that Purchaser would have been entitled to receive at the same
aggregate Conversion Price or Option Exercise Price upon such reorganization or
reclassification if Purchaser had acquired all shares of Common Stock issuable
upon conversion of the Convertible Secured Note and purchasable under the
Option, in full, immediately prior to the record date with respect to such
event; and in any such case, appropriate provision (as determined by the Board
of Directors of the Company, whose reasonable determination shall be conclusive
and, upon request by Purchaser, shall be evidenced by a certified Board
resolution delivered to Purchaser) shall be made for the application of this
Section 1.3(b) with respect to the rights and interests thereafter of Purchaser
(including but not limited to the allocation of the purchase or exercise price
between or among shares of classes of capital stock or other securities), to the
end that this Section 1.3(b) (including the adjustments of the


                                          6
<PAGE>

number of shares of Common Stock or other securities purchasable and the
purchase or exercise price thereof) shall thereafter be reflected, as nearly as
reasonably practicable, in all subsequent conversions and purchases pursuant to
this Agreement for any shares or securities or other property (or cash)
thereafter deliverable upon the conversion or purchase thereof.

              (c)  In the event of any consolidation or share exchange
reorganization of the Company with, or merger of the Company into, another
corporation (other than a consolidation, share exchange reorganization or merger
which does not result in any reclassification or change of the outstanding
Common Stock), or in case of any sale or conveyance to another person of the
property of the Company as an entirety or substantially as an entirety, the
entity formed by such consolidation, share exchange reorganization, or merger or
the person which shall have acquired such property, as the case may be, shall
execute and deliver to Purchaser a supplemental agreement providing that
Purchaser shall have the right thereafter (until the expiration of all
conversion rights under the Convertible Secured Note and all purchase rights
under the Option) to receive, pursuant to such supplemental agreement, solely
the kind and amount of shares of stock and other securities and property (or
cash) receivable upon such consolidation, share exchange reorganization, merger,
sale or transfer by a holder of the number of shares of Common Stock of the
Company which Purchaser might have acquired pursuant to the Convertible Secured
Note and Option immediately prior to such consolidation, share exchange
reorganization, merger, sale or transfer.  Such supplemental agreement shall
provide for adjustments which shall be as nearly equivalent as may be
practicable to the adjustments provided in this Section 1.3(c).

              (d)  For the purpose of this Section 1.3, the term "COMMON STOCK"
shall mean (i) the class of stock designated as Common Stock in the Restated
Articles of Incorporation of the Company (the "RESTATED ARTICLES"), at the date
of this Agreement, or (ii) any other class of stock resulting from successive
changes or reclassifications of such Common Stock.  In the event that at any
time as a result of an adjustment made pursuant to this Section 1.3, Purchaser
shall become entitled to receive any shares of capital stock of the Company
other than shares of Common Stock, thereafter the number of such other shares so
receivable pursuant to this Agreement or any of the other documents required to
be executed and delivered by the Company hereunder (the "TRANSACTION DOCUMENTS")
shall be subject to adjustment from time to time in a manner and on terms as
nearly equivalent as practicable to the provisions with respect to the Common
Stock contained in this Section 1.3, and all other provisions of this Agreement
and the other Transaction Documents with respect to the Common Stock shall apply
on like terms to any such other shares.

              (e)  Whenever the number of shares of Common Stock purchasable
pursuant to the Option or issuable upon conversion of the Convertible Secured
Note is adjusted as provided in this Section 1.3, the Conversion Price and
Option Exercise Price, respectively, for each share of Common Stock payable upon
such exercise or conversion shall be adjusted by multiplying such purchase price
or exercise price, as the case may be, immediately prior to such adjustment by a
fraction, the numerator of which shall be the number of shares of Common Stock
purchasable pursuant to the then-unexercised portion of the Option or issuable
upon conversion of the then-unconverted portion of the Convertible Secured Note
immediately prior to such


                                          7
<PAGE>

adjustment, and the denominator of which shall be the number of shares of Common
Stock so purchasable or issuable immediately thereafter.

              (f)  The provisions of Section 1.3 shall apply similarly to
successive stock dividends, subdivisions and combinations; successive
reorganizations or recapitalizations; and successive consolidations, share
exchange reorganizations, mergers, sales and transfers.

         1.4  NO FUTURE FUNDING COMMITMENT OR OBLIGATION.  Nothing in this
Agreement or any of the other Transaction Documents shall be construed as a
commitment or obligation of any kind on the part of Purchaser or any of its
members to provide any funding or other property or resources of any kind to the
Company or any of its Subsidiaries, principals or affiliates, currently or at
any time in the future, except as expressly set forth in Section 2.1(b)(i) of
this Agreement.  Except as expressly set forth in Section 2.1(b)(i) of this
Agreement, no future commitment or obligation of any kind on the part of
Purchaser or any of its members to provide any funding or other property or
resources of any kind shall be created or effective unless it is in a signed
written instrument, manually signed by or on behalf of Purchaser or such member
and delivered to the Company by Purchaser or by such member, and the Company
shall not rely on any other writing, or on any alleged or actual oral
statements, assurances or promises, or any electronic mail, to create or effect
any such commitment or obligation.


                                      ARTICLE II
                           CLOSING AND EXERCISE PROCEDURES

Section 2.  CLOSING DATES; DELIVERY.

         2.1  PURCHASE OF THE CONVERTIBLE SECURED NOTE.

              (a)  TIME AND PLACE OF CLOSING.  The closing of the purchase and
sale of the Convertible Secured Note (the "NOTE CLOSING") shall be held at the
offices of Wilson Sonsini Goodrich & Rosati, Professional Corporation, 650 Page
Mill Road, Palo Alto, California 94304-1050 at 10:00 a.m. on June 17, 1997, or
at such other time and place as the Company and Purchaser shall agree upon in
writing (the "NOTE CLOSING DATE").

              (b)  DELIVERY.  At the Note Closing, (i) Purchaser shall deliver
the sum of fifteen million three hundred thousand dollars ($15,300,000), less
the amount of expenses payable to Purchaser by the Company pursuant to Section
8.9, and (ii) the Company shall deliver to Purchaser (A) the Convertible Secured
Note, duly executed by the Company, registered in the name of Purchaser and
bearing the applicable legend(s) set forth in Section 5.11, (B) a Pledge and
Security Agreement, in the form set forth in EXHIBIT D hereto, duly executed by
the Company, (C) a Series 1 Warrant and a Series 2 Warrant, in each case duly
executed by the Company and registered in the name of Purchaser, entitling
Purchaser to purchase, in the aggregate, 850,000 shares of Common Stock (subject
to adjustment as set forth therein), and (D) the indemnification agreement
between the Company and Ellison contemplated by Section 5.3(c), effective as of
the election of Ellison to the Board of Directors of the Company, duly executed
by the Company.


                                          8
<PAGE>

The Series 1 Warrant delivered to Purchaser at the Note Closing shall entitle
Purchaser to purchase, on the terms and subject to the conditions set forth
therein, 500,000 shares of Common Stock (subject to adjustment as set forth
therein).  The Series 2 Warrant delivered to Purchaser at the Note Closing shall
entitle Purchaser to purchase, on the terms and subject to the conditions set
forth therein, 350,000 shares of Common Stock (subject to adjustment as set
forth therein).

         2.2  OPTION CLOSINGS; EXERCISE OF THE OPTION.

              (a)  EXERCISE.  The Option may be exercised by Purchaser, in
whole or in part, at any time or from time to time prior to 5:00 p.m. California
time on the Option Termination Date.  In the event that Purchaser wishes to
exercise the Option, Purchaser shall deliver to the Company written notice (an
"EXERCISE NOTICE") specifying the total number of shares of Common Stock, up to
the number of such shares provided by Section 1(b), that Purchaser wishes to
purchase.  Notwithstanding the expiration or termination of the Option,
Purchaser shall be entitled to receive the shares of Common Stock with respect
to which Purchaser had delivered an Exercise Notice prior to 5:00 p.m. on the
Option Termination Date.

              (b)  OPTION CLOSINGS.  Each closing of a purchase of shares of
Common Stock under the Option (an "OPTION CLOSING") shall occur at the offices
of the Company at 9:00 a.m. California time (or such other time and place as may
be agreed by the parties) on a date designated by Purchaser in an Exercise
Notice delivered not less than five (5) and not more than twenty (20) business
days prior to the date of such Option Closing (the "OPTION CLOSING DATE").  At
each Option Closing:  (i) the Company shall deliver to Purchaser or its designee
(A) a single certificate representing the number of shares of Common Stock
designated by Purchaser for purchase in the applicable Exercise Notice (the
"OPTION EXERCISE NUMBER"), such certificate to be registered in the name of
Purchaser and to bear the legend set forth in Section 5.11, and (B) a Series 2
Warrant, registered in the name of Purchaser, entitling Purchaser to purchase,
on the terms set forth therein, a number of shares of Common Stock (subject to
adjustment as set forth therein) equal to one half the Option Exercise Number;
and (ii) Purchaser shall deliver the aggregate Option Exercise Price for the
shares of Common Stock so designated for purchase to the Company in cash (in
immediately available funds).  Upon request by Purchaser, the Option Closing
Date will be deferred as reasonably necessary until the conditions to
consummation of the Option Closing and the Company's obligation to issue the
Option Common at such Option Closing pursuant to Section 7.3 are satisfied (if
such conditions are capable of being satisfied).

                                     ARTICLE III
                            REPRESENTATIONS AND WARRANTIES
                                    OF THE COMPANY

    Section 3.     REPRESENTATIONS AND WARRANTIES OF THE COMPANY.  Except as
disclosed in the Company SEC Reports (as defined in Section 3.14) or as set
forth in the disclosure schedule delivered by the Company to Purchaser on or
before the date of this Agreement (which disclosure schedule shall be organized
into numbered sections corresponding with the section numbers of



                                          9
<PAGE>

this Agreement) (the "COMPANY DISCLOSURE SCHEDULE"), the Company represents and
warrants to Purchaser as follows:

         3.1  ORGANIZATION, STANDING AND POWER; QUALIFICATION.  The Company and
each Subsidiary (as defined in Section 3.2 below) thereof are corporations duly
organized, validly existing and in good standing under the laws of the
jurisdiction of their incorporation, have all requisite corporate power to own,
lease and operate their property and to carry on their businesses as now being
conducted and as proposed to be conducted, and are duly qualified to do business
and are in good standing as a foreign corporation in each jurisdiction in which
the failure to be so qualified and in good standing would have a material
adverse effect on the business, assets (including intangible assets),
properties, liabilities (contingent or otherwise), financial condition,
operations, or results of operation of the Company or its Subsidiaries, taken as
a whole (a "MATERIAL ADVERSE EFFECT").  Except for the shares held by the
Company listed in Section 3.1 of the Company Disclosure Schedule, neither the
Company nor any of its Subsidiaries directly or indirectly owns any equity or
similar interest in, or any interest convertible or exchangeable or exercisable
for any equity or similar interest in, any corporation, partnership, joint
venture or other business association or entity.  The Company has delivered true
and correct copies of the Restated Articles and Bylaws, as amended (the
"BYLAWS"), of the Company to Purchaser.  The Company is not in violation of any
of the provisions of the Restated Articles or Bylaws.

         3.2  SUBSIDIARIES.

              (a)  For purposes of this Agreement, "SUBSIDIARY" means, with
respect to any party, any corporation, limited liability company, partnership,
joint venture, or other business association or entity, at least a majority of
the voting securities or economic interests of which is directly or indirectly
owned or controlled by such party or by any one or more of its Subsidiaries.

              (b)  Section 3.2 of the Company Disclosure Schedule sets forth a
list of all Subsidiaries of the Company, including the name of such Subsidiary
and the jurisdiction in which such Subsidiary is organized.  Except as set forth
in Section 3.2 of the Company Disclosure Schedule, all of the issued and
outstanding shares of capital stock of each Subsidiary are owned by the Company
and are validly issued, fully paid, and nonassessable, and there are no
outstanding subscriptions, options, call contracts, voting trusts, proxies or
other commitments, understandings, restrictions, arrangements, rights or
warrants with respect to any such Subsidiary's capital stock, including any
right obligating any such Subsidiary to issue, deliver, or sell additional
shares of its capital stock.

         3.3  CAPITALIZATION.  The authorized capital stock of the Company
consists of 40,000,000 shares of Common Stock, $.001 par value, and 2,000,000
shares of preferred stock, $.001 par value ("PREFERRED STOCK").  As of June 10,
1997, there were 17,009,292 shares of Common Stock issued and outstanding and
there were no issued and outstanding shares of Preferred Stock.  All such issued
and outstanding shares have been duly authorized and validly issued, are fully
paid and nonassessable, have been issued in compliance with all applicable state
and federal laws concerning the issuance of securities, and are not subject to
any preemptive or


                                          10
<PAGE>

similar rights.  The Company has reserved 2,431,550 shares of Common Stock for
issuance under the Company's 1993 Stock Plan and 250,000 shares for issuance
under the 1996 Director's Stock Option Plan and 294,000 shares for issuance
under other stock option plans and agreements, stock purchase plans and
agreements, stock bonus plans and agreements, or other similar arrangements
established for employees, directors or consultants of the Company (together
with the 1993 Stock Plan and the 1996 Director's Stock Option Plan, the "STOCK
PLANS").  In addition, the Company has reserved 4,205,402 shares of Common Stock
for issuance upon exercise of outstanding warrants.  Except for such shares of
Common Stock reserved for issuance under such warrants and under the Company
Stock Plans, and except for shares reserved for issuance pursuant to the
Convertible Secured Note, the Option and the Warrants, there are no outstanding
options, warrants, rights (including conversion and preemptive rights or rights
of first refusal), or other agreements to issue or purchase any shares of Common
Stock or Preferred Stock of the Company.  Except as set forth in Section 3.3 of
the Company Disclosure Schedule, the Company has not granted or otherwise
promised registration rights to any holder of the Company's securities.  Neither
the Company nor any of its Subsidiaries nor, to the knowledge of the Company and
its Subsidiaries, any of the Company's shareholders is a party or subject to any
agreement or understanding between any persons or entities which affects or
relates to the voting or giving of written consents (x) with respect to any
securities or (y) by any director of the Company or any of its Subsidiaries.

         3.4  AUTHORITY; NO CONFLICTS; APPROVALS.

              (a)  The Company has all requisite corporate power and authority
to enter into this Agreement and the other documents required to be executed and
delivered by the Company hereunder (collectively, the "TRANSACTION DOCUMENTS"),
and to consummate the transactions contemplated hereby and thereby.  The
execution and delivery of this Agreement and the other Transaction Documents and
the consummation of the transactions contemplated hereby and thereby have been
duly authorized by the Board of Directors of the Company, and no other corporate
or shareholder action or proceedings on the part of the Company, its
shareholders or directors are necessary to authorize the execution and delivery
of this Agreement or the Transaction Documents or the consummation of the
transactions contemplated hereby or thereby.  This Agreement and the other
Transaction Documents have been duly executed and delivered by the Company and
constitute the legal, valid and binding obligations of the Company, enforceable
against the Company in accordance with their terms, except as such
enforceability may be limited by bankruptcy, insolvency, moratorium or other
similar laws affecting or relating to creditors' rights generally, and general
principles of equity.

              (b)  The execution and delivery by the Company of this Agreement
and the other Transaction Documents do not, and the consummation of the
transactions contemplated hereby and thereby will not, (i) conflict with, or
result in any violation of or breach of any provision of the Restated Articles
or Bylaws of the Company, (ii) result in any violation or breach of, or
constitute (with or without notice or lapse of time, or both) a default under,
or give rise to a right of termination, cancellation or acceleration of any
material obligation or loss of any benefit under any license, assignment, note,
mortgage, indenture, lease, contract or other agreement or obligation to which
the Company or any of its Subsidiaries is a party or by which the Company or


                                          11
<PAGE>

any of its Subsidiaries or any of its properties or assets may be bound,
(iii) conflict with or violate any judgment, order, decree, statute, law,
ordinance, rule or regulation or any material permit, concession, franchise or
license applicable to the Company or any of its Subsidiaries or any of their
respective properties or assets, except in the case of (ii) for such violations,
breaches, defaults, rights of termination, cancellation or acceleration, or
losses of benefits which would not be reasonably likely to have a Material
Adverse Effect.

              (c)  No consent, approval, order or authorization of, or
registration, declaration or filing with, any governmental entity is required by
or with respect to the Company or any of its Subsidiaries in connection with the
execution and delivery of this Agreement and the other Transaction Documents or
the consummation of the transactions contemplated hereby or thereby, except that
the filing of one or more notification and report forms under the HSR Act may be
required with respect to the acquisition by Purchaser of certain of the shares
of Common Stock issuable upon conversion of the Convertible Secured Note and
purchasable pursuant to the Option, the Warrants, and Section 5.1 of this
Agreement, and except for (i) the filing by the Company of one or more
registration statements with the Securities and Exchange Commission (the "SEC")
in accordance with the Securities Act of 1933, as amended (the "SECURITIES
ACT"), pursuant to Article VI, (ii) such other consents, approvals, orders,
authorizations, registrations, declarations and filings as may be required under
applicable federal and state securities laws and the laws of any foreign
country, and (iii) such other consents, authorizations, filings, approvals and
registrations which, if not obtained or made, would not be reasonably likely to
have a Material Adverse Effect.

              (d)  The shares of Common Stock issuable upon conversion of the
Convertible Secured Note and upon exercise of the Option and Warrants, when
issued in accordance with the terms of this Agreement and upon receipt by the
Company of the applicable Conversion Price, Option Exercise Price and Warrant
Exercise Price, will be duly authorized, validly issued, fully paid and
non-assessable.

         3.5  FINANCIAL STATEMENTS.  The Company has delivered to Purchaser
copies of the Company's audited consolidated financial statements (balance
sheet, statement of operations, statement of shareholders' equity, and statement
of cash flows) for the year ended December 31, 1996 and its unaudited
consolidated financial statements (balance sheet, statement of operations,
statement of shareholders' equity, and statement of cash flows) for the quarter
ended March 31, 1997 (the "COMPANY FINANCIAL STATEMENTS").  The Company
Financial Statements were prepared in accordance with generally accepted
accounting principles ("GAAP") applied on a consistent basis throughout the
periods involved.  The Company Financial Statements present fairly in all
material respects the financial position of the Company and its Subsidiaries as
of the respective dates and the consolidated results of its operations and cash
flows for the periods indicated.

         3.6  ABSENCE OF UNDISCLOSED LIABILITIES.  Neither the Company nor any
of its Subsidiaries has any liabilities, either accrued or contingent (whether
or not required to be reflected in financial statements in accordance with
GAAP), and whether due or to become due, other than (i) liabilities reflected or
provided for on the balance sheet as of March 31, 1997 (the "COMPANY BALANCE
SHEET") contained in the Company Financial Statements, (ii) liabilities



                                          12
<PAGE>

specifically described in this Agreement or Section 3.6 of the Company
Disclosure Schedule, and (iii) normal or recurring liabilities incurred since
March 31, 1997 in the ordinary course of business consistent with past practices
that could not reasonably be expected to result in a Material Adverse Effect.

         3.7  ABSENCE OF CERTAIN CHANGES OR EVENTS.  Except as set forth in
Section 3.7 of the Company Disclosure Schedule, and except as reflected in the
Company Financial Statements, since March 31, 1997, the Company and its
Subsidiaries have conducted their businesses in the ordinary course and in a
manner consistent with past practices, and have not:

              (a)  suffered any event or occurrence that has had or could
reasonably be expected to have a Material Adverse Effect;

              (b)  declared, set aside or paid any dividend or made any other
distribution on or in respect of the shares of its capital stock or declared any
direct or indirect redemption, retirement, purchase or other acquisition of such
shares, except for purchases of stock from terminated non-officer employees in
the ordinary course of business and in a manner consistent with past practices;

              (c)  issued any shares of their capital stock or any warrants,
rights, or options for, or entered into any commitment relating to such capital
stock, except for issuances made in the ordinary course of business in arm's
length transactions for value and in a manner consistent with past practices
(including issuances made upon exercises and conversions of employee and
director stock options);

              (d)  made any material change in the accounting methods or
practices they follow, whether for general financial or tax purposes, or any
change in depreciation or amortization policies or rates;

              (e)  sold, leased, abandoned or otherwise disposed of any real
property or machinery, equipment or other operating property except in the
ordinary course of business and in a manner consistent with past practices and
in an amount that is not material to the Company and its Subsidiaries taken as a
whole;

              (f)  sold, assigned, transferred, licensed, pledged, or otherwise
disposed of or encumbered any patent, trademark, trade name, brand name, Food
and Drug Administration ("FDA") license or approval application, copyright (or
pending application for any patent, trademark or copyright), invention, work of
authorship, process, know-how, formula or trade secret or interest thereunder or
other material intangible asset, except for non-exclusive licenses which were
granted in the ordinary course of business and in a manner consistent with past
practices and in an amount that is not material to the Company and its
Subsidiaries taken as a whole;


                                          13
<PAGE>

              (g)  entered into any material commitment or transaction
(including without limitation any borrowing or capital expenditure) other than
the transactions contemplated by this Agreement and the other Transaction
Documents; or

              (h)  paid, loaned or advanced any amount to, or sold, transferred
or leased any properties or assets or rights under license to, or entered into
any agreement or arrangement with any of its officers, directors or shareholders
or any affiliate of any of the foregoing, other than employee compensation and
benefits and reimbursement of employment related business expenses incurred in
the ordinary course of business.

         3.8  TAXES.  As used in this Agreement, the terms "TAX" and,
collectively, "TAXES" mean any and all federal, state and local taxes of any
country, assessments and other governmental charges, duties, impositions and
liabilities, including taxes based upon or measured by gross receipts, income,
profits, sales, use and occupation, and value added, ad valorem, transfer,
franchise, withholding, payroll, recapture, employment, excise and property
taxes, together with all interest, penalties and additions imposed with respect
to such amounts and any obligations under any agreements or arrangements with
any other person with respect to such amounts and including any liability for
taxes of a predecessor entity.

              (a)  The Company and its Subsidiaries have prepared and timely
filed all returns, estimates, information statements and reports required to be
filed with any taxing authority ("RETURNS") relating to any and all Taxes
concerning or attributable to the Company or its Subsidiaries or their
operations with respect Taxes for any period ending on or before the Note
Closing Date, and such Returns have been completed in all material respects in
accordance with applicable law or an adequate reserve has been made for such
Taxes on the Company Balance Sheet.

              (b)  The Company and its Subsidiaries have (i) paid all Taxes
shown to be payable on such Returns covered by Section 3.8(a), and (ii) withheld
with respect to its employees all Taxes required to be withheld.

              (c)  There is no Tax deficiency outstanding or assessed against
the Company or any of its Subsidiaries that is not reflected as a liability on
the Company Balance Sheet.

              (d)  Neither the Company nor any of its Subsidiaries has any
material liabilities for unpaid Taxes that have not been accrued for or reserved
on the Company Balance Sheet, whether asserted or unasserted, contingent or
otherwise.

              (e)  Neither the Company nor any of its Subsidiaries is a party
to any tax-sharing agreement or similar arrangement with any other party, or any
contractual obligation to pay any Tax obligations of, or with respect to any
transaction relating to, any other person or to indemnify any other person with
respect to any Tax.


                                          14
<PAGE>

              (f)  Except as set forth in Section 3.8 of the Company Disclosure
Schedule, neither the Internal Revenue Service ("IRS") nor any foreign, state,
local or other taxing authority has, since the Company's inception, examined or
is in the process of examining any Returns of the Company or any of its
Subsidiaries.  To the knowledge of the Company and its Subsidiaries, neither the
IRS nor any foreign, federal, state, local or other taxing authority is now
asserting or threatening to assert any deficiency or claim for additional Taxes
(or interest thereon or penalties in connection therewith).

         3.9  TANGIBLE ASSETS AND REAL PROPERTY.  All material real property
leases of the Company and its Subsidiaries ("MATERIAL LEASES") are in good
standing, valid and effective in accordance with their respective terms, and
neither the Company nor any of its Subsidiaries is in default under any of such
leases, except where the lack of such good standing, validity and effectiveness
or the existence of such default would not be reasonably likely to have a
Material Adverse Effect.  To the knowledge of the Company and its Subsidiaries,
no other party to any of the Material Leases is in default under or in breach or
violation of, nor is there any valid basis for any claim of default, breach or
violation against any other party under any of the Material Leases or any other
agreement or instrument to which any of the Material Leases is subject or
subordinate except for such breaches, violations and defaults as would not be
reasonably likely, either individually or in the aggregate, to have a Material
Adverse Effect.

         3.10 INTELLECTUAL PROPERTY.

              (a)  The Company and its Subsidiaries own or have the right to
use, free and clear of all liens, claims and restrictions, all patents, patent
applications, trademarks, trade names, services marks, and copyrights; all
applications for and registrations of the foregoing; all licenses, trade secrets
including know-how, inventions, designs, processes, clinical studies, formulae,
methods, schematics, works of authorship, computer programs and technical data
and information and rights with respect to the foregoing; and all clinical
studies, drug approval or evaluation applications to the FDA or any other
domestic or foreign regulatory authority ("APPLICATIONS"), designs, drawings,
specifications, documentation, flow charts and diagrams incorporating, embodying
or reflecting any product of the Company or any of its Subsidiaries at any stage
of its development (a "COMPANY PRODUCT"), which are used in or necessary for the
conduct of the business of the Company and its Subsidiaries as now conducted
and, except as set forth in Section 3.10(a) of the Company Disclosure Schedule,
as planned to be conducted (as set forth in the Company's Annual Report on
Form 10-K for the year ended December 31, 1996) (all of which are referred to as
the "COMPANY INTELLECTUAL PROPERTY RIGHTS"), without infringing upon or
otherwise acting adversely to the right or claimed right of any person,
corporation or other entity under or with respect to any of the foregoing.  To
the knowledge of the Company and its Subsidiaries without having conducted any
special infringement or patent search or other investigation, the Company's and
its Subsidiaries' products and processes do not  infringe any patent not
licensed to the Company and its Subsidiaries held by any person, corporation or
other entity.  The Company and its Subsidiaries are not aware of any facts or
information likely to have an adverse affect on the validity or enforceability
of patents licensed by the Company and its Subsidiaries.  The Company and its
Subsidiaries have not received any communication alleging that the Company or
any of its Subsidiaries have violated any of the patents, trademarks, services


                                          15
<PAGE>

marks, trade names, copyrights, works of authorship, trade secrets or other
proprietary rights and processes of any other person or entity.  To the
knowledge of the Company and its Subsidiaries, there are, and have been, no
infringements by any third party of any of the Company Intellectual Property
Rights.  The Company and its Subsidiaries are not obligated or under any
liability whatsoever to make any payments by way of royalties, fees or otherwise
to any owner or licensee of, or other claimant to, any patent, trademark,
service mark, trade name, work of authorship, copyright or other intangible
asset, with respect to the use thereof or in connection with the conduct of its
business or otherwise.

              (b)  Subject to (i) the receipt and terms of requisite
governmental approvals, (ii) the geographic restrictions and royalty obligations
disclosed in the Company's SEC Reports (as defined in Section 3.14 below) and
the exhibits thereto, and (iii) the potential procurement by third parties of
additional patents extending beyond the scheduled and anticipated expiration
dates of previously disclosed patents, the Company and its Subsidiaries own, or
are licensed or otherwise possess legally enforceable rights, to make, use, and
sell, free and clear of all liens, claims and restrictions, all drugs for which
the Company or any of its Subsidiaries has submitted or publicly announced its
intention to submit any Application or for which human clinical trials sponsored
by the Company or any of its Subsidiaries are presently being conducted.

              (c)  Section 3.10(c) of the Company Disclosure Schedule contains
an accurate and complete list of (i) all material patents and patent
applications, all material Applications, and all material trademarks, trade
names, service marks and registered copyrights, included in the Company
Intellectual Property Rights, including the jurisdictions in which each such
Company Intellectual Property Right has been issued or registered or in which
any such application for such issuance, approval or registration has been filed,
and (ii) all material licenses, sublicenses, assignments, distribution
agreements and other agreements to which the Company or any of its Subsidiaries
is a party and pursuant to which any person is authorized to use any material
Company Intellectual Property Rights or has the right to manufacture, reproduce,
market or exploit any material Company Product or any adaptation, derivative or
reformulation based on any Company Product or any portion thereof.  Except as
set forth in Section 3.10(c) of the Company Disclosure Schedule, neither the
Company nor any of its Subsidiaries is a party to any agreement or arrangement
that requires or contemplates the payment to or receipt from any third party of
royalties or similar payments in connection with the development, manufacture or
commercial exploitation of any material Company Product or Company Intellectual
Property Rights.

              (d)  Neither the Company nor any of its Subsidiaries is (or as a
result of the execution and delivery of this Agreement or any of the other
Transaction Documents or the performance of any obligation hereunder or
thereunder will be) in breach of any license, sublicense, assignment or other
material agreement relating to the Company Intellectual Property Rights or any
other material license, sublicense, assignment, asset purchase agreement and
other agreement to which the Company or any of its Subsidiaries is a party and
pursuant to which the Company or any of its Subsidiaries acquired or is
authorized to use any third party technology, trade secret, know-how, process,
clinical studies, Application, patent, trademark or copyright ("LICENSED
INTELLECTUAL PROPERTY"), which is exploited by, incorporated in or forms a part
of any Company Product.


                                          16
<PAGE>

              (e)  Neither the Company nor any of its Subsidiaries (i) has
received notice that it has been sued in any suit, action or proceeding which
involves a claim of infringement of any patent, trademark, service mark,
copyright, trade secret, or other proprietary right of any third party; (ii) has
knowledge (without having conducted any special investigation) that the
manufacturing, marketing, licensing or sale of any Company Product materially
infringes any material patent, trademark, service mark, copyright, trade secret,
or other proprietary right of any third party; or (iii) has knowledge of any
claim challenging or questioning the validity or effectiveness of any material
license or agreement relating to any Company Intellectual Property Rights or
Licensed Intellectual Property.

              (f)  The Company and its Subsidiaries have at all times used
commercially reasonable efforts to treat the Company Intellectual Property
Rights as containing trade secrets and have not disclosed or otherwise dealt
with such items in such a manner as to cause the loss of such trade secrets by
their release into the public domain.

              (g)  Each person currently or formerly employed by the Company or
its Subsidiaries (including consultants, if any), that has or had access to
confidential information of the Company or any of its Subsidiaries, has executed
and delivered to the Company a confidentiality and non-disclosure agreement
("CONFIDENTIALITY AGREEMENT") substantially in the form previously provided to
Purchaser annexed as EXHIBIT E.  To the knowledge of the Company and its
Subsidiaries without having conducted any special investigation, neither the
execution nor the delivery of any Confidentiality Agreement, nor the carrying on
of the business of the Company and its Subsidiaries by each such employee and
consultant, will conflict with or result in a breach of the terms, conditions or
provisions of, or constitute a default under, any contract, covenant or
instrument under which any of such persons is obligated.

         3.11 PRODUCT LIABILITY.  Neither the Company nor any of its
Subsidiaries (i) has received notice that it has been sued in any suit, action
or proceeding which involves a claim of death, personal injury, inadequate
labelling, failure to warn or other product liability claim relating to any
Company Product; (ii) has knowledge of any threat of any such suit, action or
proceeding or any basis therefor; or (iii) has knowledge of any study, report,
claim, or investigation questioning the safety of any Company Product.

         3.12 CONTRACTS.  Neither the Company nor any of its Subsidiaries is in
default under or in breach or violation of, nor is there any valid basis for any
claim of default by the Company or any of its Subsidiaries under, or breach or
violation by the Company or any of its Subsidiaries of, any contract, license,
commitment or restriction to which the Company or any of its Subsidiaries is a
party or by which the Company or any of its Subsidiaries or any of their
respective properties or assets is bound or affected, except for such breaches,
violations and claims of default as would not be reasonably likely, either
individually or in the aggregate, to have a Material Adverse Effect.  To the
knowledge of the Company and its Subsidiaries, without having conducted any
special investigation, no other party is in default under or in breach or
violation of, nor, to the knowledge of the Company and its Subsidiaries, is
there any valid basis for any claim of default against any other party under, or
any breach or violation by any other


                                          17
<PAGE>

party of, any contract, license, commitment, or restriction to which the Company
or any of its Subsidiaries is a party or by which the Company or any of its
Subsidiaries or any of their respective properties or assets is bound or
affected, except for such breaches, violations and claims of default as would
not be reasonably likely, either individually or in the aggregate, to have a
Material Adverse Effect.

         3.13 ENVIRONMENTAL MATTERS.  As of the date hereof, no underground
storage tanks are present under any property that either the Company or any of
its Subsidiaries has at any time owned, operated, occupied or leased and no
amount of any substance that has been designated by applicable law or regulation
to be radioactive, toxic, hazardous or otherwise a danger to health or the
environment ("HAZARDOUS MATERIAL") is present as a result of the actions of the
Company or any of its Subsidiaries, or, to the knowledge of the Company and its
Subsidiaries, any actions of any third party or otherwise, in, on or under any
property, including the land and the improvements, ground water and surface
water, that the Company or any of its Subsidiaries has at any time owned,
operated, occupied or leased, where the presence of such underground storage
tanks or Hazardous Material is reasonably likely to have a Material Adverse
Effect.  At no time has the Company or any of its Subsidiaries transported,
stored, used, manufactured, disposed of, released or exposed its employees or
others to Hazardous Materials (collectively, "HAZARDOUS MATERIALS ACTIVITIES")
in violation of any law, rule, regulation, treaty or statute promulgated by any
governmental entity to prohibit, regulate or control Hazardous Materials or any
Hazardous Material Activity, which violation has had or is reasonably likely to
have a Material Adverse Effect.  The Company and its Subsidiaries hold all
environmental approvals, permits, licenses, and clearances necessary for the
conduct of business ("ENVIRONMENTAL PERMITS"), the absence of which would be
reasonably likely to have a Material Adverse Effect.  No action, proceeding,
revocation proceeding, amendment procedure, writ, injunction or claim is pending
or, to the knowledge of the Company and its Subsidiaries, threatened concerning
any Environmental Permit or any Hazardous Materials Activity of the Company or
any of its Subsidiaries.  Neither the Company nor any of its Subsidiaries is
aware of any fact or circumstance which is reasonably likely to involve the
Company or any of its Subsidiaries in any environmental litigation or impose
upon the Company or any of its Subsidiaries any environmental liability which
would be reasonably likely to have a Material Adverse Effect.

         3.14 SEC REPORTS.  The Company has timely filed all reports,
registration statements, proxy statements and other materials, together with any
amendments thereto, required to be filed by the Company with the Securities and
Exchange Commission ("SEC") under the Securities Exchange of 1934, as amended
(the "EXCHANGE ACT"), since January 1, 1996 (the "SEC REPORTS").  The Company
has furnished to Purchaser copies of its Annual Report on Form 10-K for the year
ended December 31, 1996, its Quarterly Report on Form 10-Q for the quarter ended
March 31, 1997, and all Current Reports on Form 8-K and proxy statements, as
filed with the SEC.  As of the date filed, the SEC Reports did not contain any
untrue statement of a material fact or omit to state a material fact necessary
to make the statements therein, in light of the circumstances in which they were
made, not misleading.  The financial statements contained in the SEC Reports
fairly present the financial position of the Company and its Subsidiaries as at
the dates thereof and for the periods covered thereby and have been prepared in
accordance with GAAP and with the published rules and regulations of the SEC
with respect thereto.


                                          18
<PAGE>

         3.15 EMPLOYEE BENEFIT PLANS.

              (a)  No event has occurred, and there exists no condition or set
of circumstances, with respect to the employee benefit plans of the Company
("COMPANY EMPLOYEE PLANS"), which could reasonably be expected to subject the
Company or any of its Subsidiaries to any liability, other than liabilities
which would not be reasonably likely, either individually or in the aggregate,
to have a Material Adverse Effect.

              (b)  With respect to the Company Employee Plans, individually and
in the aggregate, there are no funded benefit obligations for which
contributions have not been made or properly accrued and there are no unfunded
benefit obligations which have not been accounted for by reserves on the
Company's Financial Statements.

              (c)  Except as set forth in Section 3.15 of the Company
Disclosure Schedule, all the Company Employee Plans comply with and are and have
been operated in accordance with each applicable provision of the Employee
Retirement Income Security Act of 1974 ("ERISA"), the Internal Revenue Code of
1986, as amended (the "CODE"), other federal statutes, state law (including,
without limitation, state insurance law) and the regulations and rules
promulgated pursuant thereto or in connection therewith.  Each Company Employee
Plan which is a group health plan (within the meaning of Section 5000(b)(1) of
the Code) complies with and has been maintained and operated in accordance with
each of the requirements of Section 4980B of the Code and Part 6 of Subtitle B
of Title I of ERISA.

              (d)  Neither the Company nor any of its Subsidiaries nor any
current or former employee of the Company or any of its Subsidiaries or any
trade or business (whether or not incorporated) which is a member or which is
under common control with the Company within the meaning of Section 414 of the
Code ("ERISA AFFILIATE"), nor any officer, director, agent or employee of the
Company has made any oral or written statement regarding any Company Employee
Plan which could result in any material additional liability to Purchaser, the
Company or any ERISA Affiliate, whether direct or indirect, in excess of any
current or potential liability of the Company or any ERISA Affiliate.

         3.16 EMPLOYEES.  The Company has heretofore furnished to Purchaser a
true, complete and correct copy of the Company's employee manual and each
employment, consulting, severance and other similar agreement heretofore entered
into between the Company or any of its Subsidiaries and each person currently or
formerly employed, or engaged as a consultant, by the Company or any of its
Subsidiaries.  To the Company's knowledge, no such employee or consultant is in
material violation of any material term of any such employment or consulting
agreement, Confidentiality Agreement, or any other contract or agreement
relating to the relationship of such employee or consultant with the Company or
any of its Subsidiaries or any other party because of the nature of the business
conducted or to be conducted by the Company or any of its Subsidiaries.  Except
as set forth in Section 3.16(ii) of the Company Disclosure Schedule, all
employees and consultants are terminable at will.



                                          19
<PAGE>

         3.17 INTERESTED PARTY TRANSACTIONS.  Since the date of the Company's
most recent proxy statement to its shareholders, no event has occurred that
would be required to be reported by the Company as a Certain Relationship or
Related Transaction, pursuant to Item 404 of Regulation S-K promulgated by the
SEC.

         3.18 BROKERS OR FINDERS.  Except as contemplated by Article VI, no
agent, broker, investment banker, financial advisor or other firm or person is
or will be entitled to any broker's or finder's fee or any other commission or
similar fee in connection with any of the transactions contemplated by this
Agreement or any of the other Transaction Documents, and the Company and its
Subsidiaries agree to indemnify and hold Purchaser harmless from and against any
and all claims, liabilities or obligations with respect to any other fees,
commissions or expenses asserted by any person on the basis of any act or
statement alleged to have been made by the Company or any of its Subsidiaries.

         3.19 COMPLIANCE WITH LAWS.  The Company and its Subsidiaries have
complied in all material respects with all applicable federal, state, local and
foreign statutes, laws and regulations, and are not in violation of, and have
not received any notices of violation with respect to, any such statute, law or
regulation, with respect to the conduct, ownership or operation of their
businesses, including, without limitation, the federal Food and Drug Act,
Foreign Corrupt Practices Act and all United States statutes, laws and
regulations as from time to time in effect that govern the license and delivery
of technology and products abroad by persons subject to the jurisdiction of the
United States.  The Company and its Subsidiaries have obtained each governmental
consent, license, permit, grant or other authorization of a governmental entity
that is required for the operation of its business as currently conducted
(collectively, the "COMPANY AUTHORIZATIONS"), and all such Company
Authorizations are in full force and effect, except for such Company
Authorizations which, if not obtained by the Company or any of its Subsidiaries,
would not be reasonably likely, either individually or in the aggregate, to have
a Material Adverse Effect.

         3.20 LITIGATION.  Except as set forth in Section 3.20 of the Company
Disclosure Schedule, there is no action, suit, proceeding, claim, arbitration or
investigation, pending before any agency, court or tribunal, or to the knowledge
of the Company and its Subsidiaries, threatened, against the Company, its
Subsidiaries or any of their respective properties or officers or directors (in
their capacities as such), and, to the knowledge of the Company and its
Subsidiaries, there is no valid basis for any action, suit, proceeding, claim,
arbitration or investigation, against the Company which if determined adversely
to the Company or any of its Subsidiaries, could reasonably be expected to have
a Material Adverse Effect.  There is no judgment, decree or order against the
Company or any of its Subsidiaries or, to the knowledge of the Company and its
Subsidiaries, any of their respective directors or officers (in their capacities
as such) that could prevent, enjoin, or materially alter or delay any of the
transactions contemplated by this Agreement or that could reasonably be expected
to have a Material Adverse Effect.

         3.21 RESTRICTIONS ON BUSINESS ACTIVITIES.  There is no agreement,
judgment, injunction, order or decree binding upon the Company or any of its
Subsidiaries which limits or


                                          20
<PAGE>

restricts the Company from competing (geographically, by field of endeavor, or
otherwise) or which has or could reasonably be expected to have the effect of
prohibiting or materially impairing any material current business practice of
the Company or any of its Subsidiaries, or the conduct of business by the
Company or any of its Subsidiaries as currently conducted or as proposed to be
conducted in public announcements by the Company.

         3.22 NO MISREPRESENTATION.  No representation or warranty by the
Company in this Agreement or any of the other Transaction Documents, and no
statement, certificate or schedule furnished or to be furnished by or on behalf
of the Company pursuant to this Agreement or any of the other Transaction
Documents, when taken together, contains any untrue statement of a material fact
or omits to state a material fact required to be stated therein or necessary in
order to make such statements, in light of the circumstances under which they
were made, not misleading.


                                      ARTICLE IV
                            REPRESENTATIONS AND WARRANTIES
                                     OF PURCHASER

    Section 4.     REPRESENTATIONS AND WARRANTIES OF PURCHASER.  Purchaser
represents and warrants to the Company as follows:

         4.1  ORGANIZATION.  Purchaser is duly organized and validly existing
under the laws of the State of California.  Purchaser has the requisite power
and authority to enter into this Agreement and to carry out its obligations
hereunder.

         4.2  AUTHORITY.

              (a)  The execution and delivery of this Agreement and the
consummation of the transactions contemplated hereby have been authorized by all
necessary company action on behalf of Purchaser and constitutes the legal, valid
and binding obligation of Purchaser, except as such enforceability may be
limited by bankruptcy, insolvency, moratorium or other similar laws affecting or
relating to creditors' rights generally, and general principles of equity.

              (b)  No consent, approval, order or authorization of, or
registration, declaration or filing with, any governmental entity is required by
or with respect to Purchaser in connection with the execution and delivery of
this Agreement or the consummation of the transactions contemplated hereby,
except that the filing of one (1) or more notification and report forms under
the HSR Act may be required with respect to the acquisition by Purchaser of
certain of the shares of Common Stock issuable upon conversion of the
Convertible Secured Note and the shares of Common Stock purchasable pursuant to
the Option, the Warrants, and Section 5.1 of this Agreement, and except for
(i) the filing by the Company of one or more registration statements with the
SEC in accordance with the Securities Act pursuant to Article VI, (ii) such
other consents, approvals, orders, authorizations, registrations, declarations
and filings as may be


                                          21
<PAGE>

required under applicable federal and state securities laws and the laws of any
foreign country, and (iii) such other consents, authorizations, filings,
approvals and registrations which, if not obtained or made, would not be
reasonably likely to have a material adverse effect on the ability of Purchaser
to execute and deliver this Agreement and to perform its obligations thereunder.

         4.3  ACQUISITION FOR INVESTMENT.

              (a)  Purchaser is acquiring the Convertible Secured Note, the
Option and the Warrants, and will acquire any shares of Initial Common issued
upon conversion of the Convertible Secured Note, any shares of Option Common
purchased upon exercise of the Option and any shares of Common Stock purchased
upon exercise of the Series 1 Warrants and Series 2 Warrants (collectively, the
"SECURITIES"), solely for Purchaser's own account for investment and not with a
view to, or for resale in connection with, any distribution thereof within the
meaning of the Securities Act.  Purchaser further represents that Purchaser does
not have any present intention of selling, offering to sell or otherwise
disposing of or distributing the Securities or any portion thereof.  Purchaser
acknowledges and understands that the entire legal and beneficial interest of
the Securities Purchaser is acquiring is being purchased for, and will be held
for the account of, Purchaser only and neither in whole nor in part for any
other person.  Purchaser understands that the Securities have not been
registered under the Securities Act or other securities laws in reliance on
specific exemptions therefrom, which exemptions depend upon, among other things,
the bona fide nature of Purchaser's investment intent as expressed herein.

              (b)  Purchaser is an "accredited" investor as defined in
Regulation D under the Securities Act.

              (c)  Purchaser further acknowledges and understands that the
Securities must be held indefinitely unless they are subsequently registered
under the Securities Act or an exemption from such registration is available.
Purchaser understands that the certificate(s) evidencing the Securities will be
imprinted with a legend that prohibits the transfer of the Securities unless
they are registered or such registration is not required.

              (d)  Purchaser understands that Rule 144 promulgated under the
Securities Act permits limited resale of shares purchased in a private placement
subject to the satisfaction of certain conditions, including, among other
things, the existence of a public market for the Securities, the availability of
certain current public information about the Company, more than one year having
elapsed between the resale and the date the security to be sold was last held by
the Company or an affiliate of the Company, the sale being made through a
"broker's transaction" or in transactions directly with a "market maker," and
the number of shares being sold during any three-month period not exceeding
specified limitations.  Purchaser is further aware that Rule 144(k) permits
persons who have not been affiliates of the Company for at least three months
and whose shares have been beneficially owned by a person other than the Company
or its affiliates for at least two years after full payment for such shares to
sell such shares without regard to the current public information, manner of
sale and volume limitations described above.


                                          22
<PAGE>

              (e)  The Company has not, and will not, incur, directly or
indirectly, as a result of any action taken by Purchaser, any liability for
brokerage or finders' fees or agents' commissions or any similar charges in
connection with this Agreement.

              (f)  Purchaser has reviewed with its own tax advisers the
federal, state, and local tax consequences of this investment and the
transactions contemplated by this Agreement and has relied solely on such
advisers and not on any statements or representations of the Company or any of
its agents.  Purchaser understands that it (and not the Company) shall be
responsible for its own tax liability that may arise as a result of this
investment or the transactions contemplated by this Agreement.

         4.4  BROKERS OR FINDERS.  Except as contemplated by Article VI, no
agent, broker, investment banker, financial adviser or other firm or person is
or will be entitled to any broker's or finder's fee, or any other commission or
similar fee, in connection with any of the transactions contemplated by this
Agreement or any of the other Transaction Documents, and Purchaser agrees to
indemnify and hold the Company and its Subsidiaries harmless from and against
any and all claims, liabilities or obligations with respect to any such fees or
commissions asserted by any person on the basis of any act or statement
determined to have been made to such person by Purchaser.


                                          23
<PAGE>


                                      ARTICLE V
                                ADDITIONAL AGREEMENTS

    Section 5.     ADDITIONAL AGREEMENTS.

         5.1  PRE-EMPTION RIGHT WITH RESPECT TO COMPANY OFFERINGS.

              (a)  TO PURCHASE ADDITIONAL SHARES OF COMMON STOCK.  Prior to any
sale or issuance by the Company of any shares of capital stock of the Company or
any security exercisable for or convertible into such capital stock ("CAPITAL
STOCK") (other than a sale or issuance within the meaning of Section 5.1(d)),
the Company shall give Purchaser written notice (the "NOTICE OF ISSUANCE") of
the Company's intention to sell and issue such Capital Stock, setting forth the
proposed price, quantity and other material terms and conditions under which the
Company proposes to make such sale (the date such notice is received by
Purchaser is hereinafter referred to as the "NOTICE DATE").  Prior to any sale
or issuance by the Company of any Capital Stock, Purchaser shall have the right
to purchase a portion of such Capital Stock on terms which, subject to this
Section 5.1, are at least as favorable to Purchaser as the terms on which the
Company is willing and proposes to sell such Capital Stock to other prospective
investors.  Purchaser shall have twenty (20) days after the Notice Date to
notify the Company in writing that it elects to purchase some or all of its
share of the Capital Stock so offered.  The amount of Capital Stock which
Purchaser is entitled to acquire shall be equal to (i) the amount of Capital
Stock proposed to be sold or issued by the Company multiplied by (ii) a fraction
calculated by dividing (A) the number of shares of Common Stock (including
Initial Common) owned by Purchaser or issued and issuable upon exercise,
conversion or exchange of the Convertible Secured Note and all Warrants, Options
and other securities of the Company held by Purchaser as of the Notice Date by
(B) the total number of shares of Common Stock issued and outstanding or
issuable upon exercise, conversion or exchange of all outstanding options,
warrants and other convertible securities of the Company ("TOTAL EQUITY
SECURITIES") as of the Notice Date (shares purchasable by Purchaser pursuant to
this Section 5.1(a) are referred to as "PURCHASER'S CAPITAL STOCK").
Notwithstanding the foregoing, in no event shall Purchaser be entitled to
purchase pursuant to this Section 5.1(a) shares in excess of the 25% limitation
set forth in Section 5.5(a) below.

              (b)  COMPANY SALE.  If, within twenty (20) days after the Notice
Date, Purchaser does not notify the Company that it desires to purchase all or a
portion of Purchaser's Capital Stock, then the Company may, during a period of
ninety (90) days following the end of such twenty (20) day period, sell and
issue such Capital Stock not otherwise purchased by Purchaser to other third
parties at a price and upon terms and conditions no more favorable to such
parties than those set forth in the Notice of Issuance.  In the event that the
Company has not sold such Capital Stock to such parties within such ninety (90)
day period, the Company shall not thereafter issue or sell any Capital Stock
without first offering such securities to Purchaser in the manner provided in
this Section 5.1.

              (c)  PURCHASE; PAYMENT.  If Purchaser elects to purchase Capital
Stock pursuant to this Section 5.1, Purchaser and the Company shall use their
reasonable best efforts to


                                          24
<PAGE>

consummate the purchase and sale of such Capital Stock within sixty (60) days
after the Notice Date, and, subject to this Section 5.1(c), the terms of such
purchase and sale shall be at least as favorable to Purchaser as those set forth
in the Notice of Issuance.  The closing of such purchase shall take place as
promptly as practicable after all regulatory filings required for the
consummation of such purchase have been obtained, at such time, on such date,
and at such location as the parties shall mutually agree.  Payment for such
Capital Stock shall be by check (or wire transfer of immediately available funds
to an account designated by the Company by written notice delivered to Purchaser
not less than two (2) business days prior to the scheduled closing of such
purchase) against delivery of Purchaser's Capital Stock at the executive offices
of the Company at the time of the scheduled closing therefor.  The Company shall
take all such action as may reasonably be required by any regulatory authority
in connection with the exercise by Purchaser of the right to purchase Capital
Stock as set forth in this Section 5.1(c).

              (d)  LIMITATION.  The right contained in this Section 5.1 shall
not apply to the issuance by the Company on or after the date hereof of shares
of Capital Stock within the scope of Section 1.2(c).

              (e)  TERMINATION.  The right contained in this Section 5.1 shall
terminate upon the earliest of (i) the closing of any merger, consolidation,
share exchange, or other reorganization or business combination of the Company
with any corporation in which the shareholders of the Company immediately prior
to such merger, consolidation, share exchange or other reorganization or
business combination do not own more than fifty percent (50%) of the voting
Capital Stock of the surviving or acquiring corporation or resulting entity
immediately following such merger, consolidation, share exchange or other
reorganization or business combination, (ii) the sale of all or substantially
all of the Company's assets, or (iii) at such time as Purchaser no longer owns
at least five percent (5%) of the Common Stock of the Company on either a
primary or fully diluted basis.

         5.2  STOCK PLANS.  Until the earlier of the seventh anniversary of the
date of this Agreement or such time as Purchaser no longer owns, either outright
or pursuant to rights to acquire, at least five percent (5%) of the Common Stock
of the Company on either a primary or fully diluted basis, the Company shall not
cause or permit the aggregate number of shares of Common Stock issued or
issuable under all Stock Plans to exceed twelve percent (12%) of the Company's
Total Equity Securities.  Any waiver by Purchaser of this twelve percent (12%)
limit shall constitute a like modification of the twelve percent (12%)
limitation referenced in Section 1.2(c)(i).

         5.3  BOARD REPRESENTATION.

              (a)  Effective on the day after the Note Closing Date, the
Company shall increase by one (1) the number of members of the Board of
Directors of the Company and shall elect and appoint a representative of
Purchaser designated by Purchaser and reasonably acceptable to the Company (the
"PURCHASER REPRESENTATIVE") to such newly created directorship.  The Company and
Purchaser agree that Ellison will be the initial Purchaser Representative.  From
and after the election of Purchaser Representative as a Director of the Company,
and for as long


                                          25
<PAGE>

as Purchaser Representative shall remain a Director of the Company pursuant to
this Section 5.3, Purchaser Representative shall be entitled to serve as a
member of any executive committee of the Board of Directors of the Company and
any other committee or body performing the functions of an executive committee
(the "EXECUTIVE COMMITTEE").  As long as Purchaser beneficially owns not less
than 850,000 shares of Common Stock (as adjusted for the events described in
Section 1.3 in a manner consistent therewith), (i) the Board of Directors of the
Company shall nominate and recommend the Purchaser Representative for election
as a Director of the Company, and shall otherwise use its reasonable best
efforts to cause the election of such Purchaser Representative as a Director of
the Company at each meeting of the Company's shareholders at which the Purchaser
Representative's term as a Director would otherwise expire, and (ii) Purchaser
shall be entitled to designate one individual who shall receive notice of all
meetings of the Board of Directors and the Executive Committee of the Company
and who shall be entitled to attend and participate in all such meetings as an
observer on behalf of Purchaser (the "OBSERVER").  Subject to Section 5.3(b),
each Purchaser Representative shall be treated equally with the other Directors
and the other members of the Executive Committee in their capacities as such and
shall be entitled to the same information (including reports, financial
statements, notices and other information) at the same time (subject to the same
general conflicts-of-interest rules applicable to all other members of the Board
of Directors and Executive Committee of the Company, reasonably and consistently
applied) and the same compensation and benefits, as shall be provided to other
Directors of the Company and other members of the Executive Committee, and
copies of all such information shall be provided or made available to the
Observer at the same time such information is provided or made available to
Purchaser and other Directors or Executive Committee members.

              (b)  Notwithstanding any other provisions of this Agreement, the
rights of the Purchaser Representative to serve as a Director and as a member of
the Executive Committee, and the rights of the Observer to attend and
participate in meetings of the Board of Directors and the Executive Committee,
pursuant to Section 5.3(a) shall terminate upon the earlier of:  (i) the
Company's sale of all or substantially all of its assets, (ii) a merger,
consolidation, share exchange, or other reorganization or business combination
involving the Company in which shareholders of the Company immediately prior to
such merger, consolidation, share exchange or other reorganization or business
combination own less than fifty percent (50%) of the voting capital stock of the
surviving or acquiring corporation or the resulting entity, or (iii) such time
as Purchaser no longer owns 850,000 shares of Common Stock (as adjusted for the
events described in Section 1.3 in a manner consistent therewith).  At any time
Purchaser is no longer entitled to Board representation pursuant to this
Section 5.3, then at the request of the Company, the Purchaser Representative
shall immediately resign and the Observer shall immediately cease attending any
meetings of the Board of Directors and the Executive Committee.

              (c)  In addition to any other indemnification and insurance
rights the Purchaser Representative and the Observer may have, (i) each
Purchaser Representative (A) shall have the same indemnification rights, as set
forth in the Company's Restated Articles and Bylaws, as the other members of the
Board of Directors of the Company, and the Company shall afford each Purchaser
Representative an opportunity to enter into an indemnification agreement
substantially similar to the then effective indemnification agreement between
the Company and the


                                          26
<PAGE>

other members of the Board of Directors; and (B) shall be covered by director
and officer liability insurance to the same extent as other members of the Board
of Directors of the Company, and (ii) to the maximum extent applicable, each
Observer (A) shall have analogous rights to indemnification from the Company
which are substantially similar in scope to those of the Purchaser
Representative and (B) shall be covered at the Company's expense by liability
insurance comparable in scope to the insurance required to be obtained for
Purchaser Representative to the extent such issuance is available on
commercially reasonable terms at commercially reasonable cost.

         5.4  CERTAIN AGREEMENTS OF DIRECTORS, OFFICERS AND KEY EMPLOYEES OF
THE COMPANY.  The Company shall use its reasonable best efforts to cause Joseph
Rubinfeld, Ph.D., David M. Fineman, Elliott Fineman and Greg Swendsen to execute
and deliver to Purchaser, at or prior to the Note Closing, an agreement in
substantially the form set forth in EXHIBIT F, and to cause each other officer
of the Company to execute and deliver to Purchaser, at or prior to the Note
Closing, an agreement in substantially the form set forth in EXHIBIT G.

         5.5  STANDSTILL PROVISIONS.

              (a)  Except with the prior written consent of the Company's Board
of Directors, neither Purchaser nor Ellison shall (and neither Purchaser nor
Ellison shall permit its or his majority-owned and controlled affiliates to)
acquire, either directly or indirectly, agree to acquire, or make a tender or
exchange offer to acquire, any shares of voting capital stock, any securities
convertible into or exchangeable for voting capital stock, or any other right to
acquire voting capital stock ("VOTING STOCK") of the Company, unless (a) such
Voting Stock is acquired for investment purposes only and not with a view to any
change in control of the Company; and (b) following such acquisition, Purchaser,
Ellison, and its and his majority-owned and controlled affiliates will
beneficially own, in the aggregate, not more than twenty five percent (25%) of
the Company's Total Equity Securities.

              (b)  PARTICIPATION IN SOLICITATIONS.  Except with the prior
written consent of the Company's Board of Directors, neither Purchaser nor
Ellison shall (and neither Purchaser nor Ellison shall permit its or his
majority-owned and controlled affiliates to) (i) solicit proxies in respect of
any Voting Stock, (ii) become a "participant" or "participant in a
solicitation", as those terms are defined in Rule 14a-11 under the Exchange Act,
in opposition to a solicitation by the Company, (iii) form or join any group
with any other person for the purpose of voting, holding, purchasing or
disposing of Voting Stock, or (iv) deposit any shares of Voting Stock in a
voting trust or, except as otherwise provided herein, subject any Voting Stock
to any arrangement or agreement with respect to the voting of such Voting Stock
with any person or group other than the Company.

              (c)  SUSPENSION FROM RESTRICTIONS.  The restrictions set forth in
the foregoing Sections 5.5(a) and 5.5(b) shall be suspended in the event that
any person or group (as such term is defined under the Exchange Act) (other than
Purchaser or Ellison, any person who is then an affiliate of Purchaser or
Ellison, or any person who is an affiliate of the Company as of the date of this
Agreement (a "THIRD PARTY")), (i) without the prior approval of the Board of
Directors of the


                                          27
<PAGE>

Company, acquires, directly or indirectly, in a single transaction or a series
of transactions, or commences or publicly announces its intention to commence an
unsolicited tender offer or exchange offer for, securities representing more
than twenty percent (20%) of the then-outstanding equity securities or voting
power of the Company or any of its material Subsidiaries, or (ii) files a proxy
statement under the Exchange Act, or commences or publicly announces its
intention to engage in a solicitation of proxies, for the election of persons as
directors of the Company who, if elected, would constitute a majority of the
Board of Directors of the Company, in opposition to the nominees of the
incumbent Board of Directors of the Company.  The restrictions set forth in
Sections 5.5(a) and 5.5(b) shall be restored in the event that a Third Party
(x) ceases to own twenty percent (20%) or more of the outstanding shares of
Common Stock of the Company and (y) absolutely and unconditionally withdraws and
abandons (A) any tender or exchange offer theretofore commenced or announced by
such Third Party for more than twenty percent (20%) of the outstanding shares of
Common Stock of the Company, and (B) any solicitation of proxies within the
scope of clause (ii) of this Section 5.5(c); PROVIDED, HOWEVER, that in the
event the restrictions set forth in Sections 5.5(a) and 5.5(b) are restored,
Purchaser shall not be required to sell any Common Stock or other securities of
the Company acquired, or to withdraw, abandon or terminate any tender or
exchange offer, proposal, solicitation, or other action commenced, while the
restrictions set forth in Sections 5.5(a) and 5.5(b) were suspended pursuant to
this Section 5.5(c).

              (d)  NOTICE OF PURCHASER POSITION.  Upon written request from the
Company, a duly authorized officer of Purchaser will certify to the Company in
writing the numbers and classes of shares of Voting Stock beneficially owned by
Purchaser and Ellison and its and his majority-owned and controlled affiliates
as of any record date or other date reasonably requested.

              (e)  TERMINATION OF STANDSTILL.  Notwithstanding any other
provision in this Agreement all rights and obligations of any party under this
Section 5.5 will terminate and expire upon the seventh anniversary of the date
of the Note Closing.

         5.6  FINANCIAL STATEMENTS AND OTHER REPORTS.

              (a)  As long as Purchaser beneficially owns, either outright or
pursuant to rights to acquire, at least five percent (5%) of the Common Stock of
the Company on either a primary or fully diluted basis, the Company shall
deliver to Purchaser, promptly after transmission thereof, copies of all such
financial statements, proxy statements, notices and reports as the Company shall
send to its public stockholders and copies of all registration statements
(without exhibits), other than registration statements on Form S-8 or any
similar successor form, and all reports which it files with the SEC (or any
governmental body or agency succeeding to the functions of the SEC).  Purchaser
shall have the right to discuss such financial statements, proxy statements,
notices, reports, registration statements and filings with such officers of the
Company as Purchaser may reasonably designate upon reasonable notice and at
reasonable times, and to share such information with Purchaser's professional
advisers, subject to the confidentiality provisions set forth in Section 5.7.


                                          28
<PAGE>

              (b)  Prior to the Option Termination Date, the Company shall
permit representatives of Purchaser to visit and inspect, at Purchaser's
expense, any of the properties of the Company, to examine the corporate books
and make copies or extracts therefrom and to discuss the affairs, finances and
accounts of the Company and its Subsidiaries with the principal officers of the
Company, all upon reasonable notice and at such reasonable times and as often as
Purchaser may reasonably request.

         5.7  CONFIDENTIALITY.  Except as permitted by Section 5.8, Purchaser
agrees (and shall cause its professional advisers to agree) not to disclose to
any person any information or data obtained by them pursuant to Sections 5.6
until such information or data otherwise becomes publicly available or except
pursuant to a valid subpoena, judicial process or its equivalent or as otherwise
required by law.  At the Company's request, Purchaser shall, and shall cause its
professional advisers to, sign a confidentiality agreement, in form and
substance reasonably satisfactory to Purchaser and the Company, as a condition
to the receipt of confidential nonpublic information of the Company by such
advisers pursuant to Sections 5.6.

         5.8  PUBLIC ANNOUNCEMENTS.  Each of the parties hereto will cooperate
with each other in the development and distribution of all news releases and
other public information disclosures with respect to this Agreement and the
other Transaction Documents and any of the transactions contemplated hereby and
thereby, and neither party hereto directly or indirectly through its officers
and directors shall make any further announcement, news release or disclosure
without first consulting with the other party hereto except (a) with the prior
written consent of the other party or (b) to the extent such party believes in
good faith, after consultation with legal counsel, that such announcement,
release or disclosure is required by law.  The Company shall not, and shall
cause its officers and directors not to, make or contribute to any public
statement, news release or other public communication or filing disclosing
personal information concerning Purchaser or any member of Purchaser without the
prior written consent of Purchaser and such member unless the Company believes
in good faith, after consultation with legal counsel, that such statement,
release, communication or filing is required by law.

         5.9  HSR ACT.  As soon as practicable (and in no event later than ten
(10) business days) after the Note Closing, the Company and Purchaser shall file
notification and report forms under the HSR Act, and shall thereafter promptly
make any and all further filings and submissions which may be required, relating
to the acquisition by Purchaser of shares of Common Stock pursuant to the
Convertible Secured Note, the Option and the Warrants).  The Company and
Purchaser shall furnish to the other such necessary information and reasonable
assistance as may be reasonably requested in connection with the preparation of
necessary filings or submissions to any governmental agency or authority
necessary under the provisions of the HSR Act.  The Company and Purchaser will
supply each other with copies of all correspondence, filings or communications
(or memoranda setting forth the substance thereof) between such party or its
representatives, on the one hand, and any such governmental agency or authority,
on the other hand, with respect to this Agreement and the other Transaction
Documents or the transactions contemplated hereby or thereby.  The Company shall
be responsible for all applicable filing fees under the HSR Act relating to the
acquisitions of Common Stock under the Convertible Secured Note, the Option, and
the Warrants.  Purchaser agrees not to designate an Option


                                          29
<PAGE>

Closing Date or exercise Warrants on any date prior to the expiration or early
termination of the applicable waiting periods under the HSR Act.

         5.10 CERTAIN RESTRICTIONS.  For a period of five years (or such
shorter period as may be specified elsewhere in this Section 5.10) commencing on
the date of this Agreement:

              (a)  RESTRICTIONS ON TRANSFER OF COMMON STOCK.  Purchaser shall
not, directly or indirectly, sell or transfer any Voting Stock except (i) to the
Company or any person or group approved by the Company; or (ii) to any entity of
which Ellison owns securities representing not less than a majority of the
voting power and which agrees to accept such Voting Stock subject to the
restrictions and obligations set forth in Section 5.5; or (iii) pursuant to a
transaction involving the merger, sale or reorganization of the Company as
approved by the Board of Directors of the Company; or (iv) pursuant to a bona
fide public offering registered under the Securities Act of Voting Stock (which
shall be structured to distribute such shares or rights through an underwriter
or otherwise in the manner set forth in Article VI or in another manner
reasonably calculated not to result in the transfer to a single person or group
of beneficial ownership of Voting Stock with aggregate voting power of five
percent (5%) of more of the total Voting Stock of the Company then outstanding);
or (v) pursuant to Rule 144 (but not pursuant to Rule 144A) under the Securities
Act (but only to the extent the sale or transfer of Voting Stock is in
compliance with the volume limitations under paragraph (e) thereof, if
applicable); or (vi) in response to (A) an offer to purchase or exchange for
cash or other consideration any Voting Stock (1) which is made by or on behalf
of the Company or (2) which is made by another person or group and is not
opposed by the Board of Directors of the Company within the time such Board is
required, pursuant to regulations under the Exchange Act, to advise the
Company's shareholders of such Board's position on such offer, or (B) subject to
the Company's right of first refusal as set forth in Section 5.10(b)(ii), any
other tender offer made by another person or group to purchase or exchange for
cash or other consideration any Voting Stock which, if successful, would result
in such person or group owning or having the right to acquire Voting Stock with
aggregate voting power of more than forty percent (40%) of the total Voting
Stock of the Company then in effect; or (vii) subject to the Company's right of
first refusal as set forth in Section 5.10(b)(i), in transactions not otherwise
described herein as long as Purchaser reasonably believes that such transactions
will not, directly or indirectly, result in any single person or group acquiring
beneficial ownership of Voting Stock with aggregate voting power of five percent
(5%) or more of the total Voting Stock of the Company then outstanding.

              (b)  RIGHT OF FIRST REFUSAL ON PERMITTED SALES.

                   (i)  GENERAL.  Until the third anniversary of the date of
this Agreement, prior to making any sale or transfer of any Common Stock
pursuant to Section 5.10(a)(vii), if such sale or transfer could reasonably be
expected to result in any single person or group acquiring beneficial ownership
of Voting Stock with aggregate voting power of five percent (5%) or more of the
total Voting Stock of the Company then outstanding, Purchaser shall give the
Company the opportunity to purchase such Common Stock in the following manner:


                                          30
<PAGE>

                        (A)  Purchaser shall give notice (the "TRANSFER
NOTICE") to the Company in writing of such intention, specifying the names of
the proposed purchasers or transferees, the securities proposed to be sold or
transferred, the proposed price per share therefor (the "TRANSFER PRICE") and
the other material terms upon which such disposition is proposed to be made.

                        (B)  The Company shall have the right, exercisable by
written notice given by the Company to Purchaser within five (5) days after
receipt of such Transfer Notice to agree to purchase all or part of the
securities specified in such Transfer Notice.  The Company shall have the right
to pay for such securities:  (A) the same amount in cash per share, if the
consideration to be paid by the third party consists of cash, or (B) to the
extent the consideration to be paid by the third party does not consist of cash,
consideration per share equivalent to that offered by the third party, or an
amount of cash having equivalent value as determined by an investment banking
firm mutually agreed to by the Company and Purchaser.

                        (C)  If the Company exercises its right of first
refusal hereunder, the closing of the purchase of the securities with respect to
which such right has been exercised shall take place within ten (10) days after
the Company gives notice of such exercise, or such longer period as Purchaser
and the Company may agree.  Upon exercise of its right of first refusal, the
Company and Purchaser shall be legally obligated to consummate the purchase
contemplated thereby and shall use their reasonable best efforts to secure any
approvals required in connection therewith.

                        (D)  If the Company does not exercise its right of
first refusal hereunder within the time specified for such exercise, Purchaser
shall be free, subject to the terms of Section 5.10(a), during the period of one
hundred and twenty (120) days following the expiration of such time for
exercise, to sell the securities specified in such Transfer Notice on terms no
less favorable to Purchaser than the terms specified in such Transfer Notice.

                   (ii) RIGHT OF FIRST REFUSAL ON TENDER OFFER.  Prior to
making any sale or exchange of Voting Stock pursuant to Section 5.10(a)(vi)(B)
in response to a tender or exchange offer, Purchaser shall give the Company the
opportunity to purchase such Voting Stock in the following manner:

                        (A)  Purchaser shall give notice (the "TENDER NOTICE")
to the Company in writing of its intention to tender such shares no later than
5:00 p.m. California time on the third business day prior to the latest date (as
the same may be extended) by which Voting Stock must be tendered in order to be
accepted pursuant to such offer or to qualify for any proration applicable to
such offer (the "TENDER DATE"), specifying the amount of Voting Stock proposed
to be tendered.  For purposes hereof, a tender or exchange offer to purchase
Voting Stock shall be deemed to be an offer at the price or other consideration
specified therein, without regard to any provisions thereof with respect to
proration or conditions to the offeror's obligation to purchase (assuming such
conditions are not impossible of performance when the offer is made, without
giving effect to the Company's right of first refusal).


                                          31
<PAGE>

                        (B)  If the Tender Notice is given, the Company shall
have the right, exercisable by giving notice (the "PURCHASE NOTICE") to
Purchaser no later than 5:00 p.m. California time on the business day
immediately preceding prior to the Tender Date, to purchase all or part of the
Voting Stock specified in the Tender Notice for cash.  If the Company exercises
such right by giving such notice, the closing of the purchase of such Voting
Stock shall take place on the fifth business day after the consummation (or the
withdrawal or abandonment under the circumstances set forth in the proviso
below, as the case may be) of the tender or exchange offer or such earlier time
as the Company and Purchaser shall agree.  As a condition to the effectiveness
of any exercise by the Company of its rights to purchase under
Sections 5.10(b)(ii), at the time the Company delivers a Purchase Notice, it
shall have provided for the payment to Purchaser of the purchase price for the
shares to be purchased by the Company, by an escrow of funds, letter of credit
facility, bank guarantee or similar arrangement reasonably acceptable to
Purchaser.  If the purchase price specified in the tender or exchange offer
includes any property other than cash, the value of any property included in the
purchase price, for purposes of determining the amount to be provided for by the
Company pursuant to the preceding sentence only, shall be determined by an
investment banking firm mutually agreed to by the Company and Purchaser.  Upon
exercise of the right of first refusal pursuant to this Section 5.10(b)(ii)
(including provision for payment as described above), the Company and Purchaser
shall be legally obligated to consummate the purchase and sale contemplated
thereby and shall use their reasonable best efforts to secure any approvals
required in connection therewith; PROVIDED, that the Company's obligation to
consummate such purchase shall cease if the tender or exchange offer is not
consummated (unless the minimum tender condition (if any) thereunder was not
satisfied and such condition would have been satisfied if Purchaser had tendered
the shares specified in its Tender Notice, in which event the Company's
obligation to consummate such purchase shall remain in effect); and PROVIDED
FURTHER, that Purchaser's obligation to consummate such sale shall cease if
Purchaser shall withdraw its Tender Notice and shall refrain from tendering the
shares specified therein.

                        (C)  If the Company does not exercise its right of
first refusal in accordance with the procedures set forth in
Section 5.10(b)(ii)(B) or fails to timely complete any purchase pursuant to an
exercise of such rights, then Purchaser shall be free to accept the tender or
exchange offer.  Purchaser may not tender any shares pursuant to such tender or
exchange offer unless Purchaser has provided the Company with a Tender Notice in
compliance with the requirements of  Section 5.10(b)(ii)(A) and the Company has
failed to exercise its right of first refusal or failed to timely consummate the
purchase of shares in compliance with the requirements of
Section 5.10(b)(ii)(B).

                        (D)  Notwithstanding any other provision of this
Agreement, no notice required by this Section 5.10(b)(ii) shall be deemed to
have been given, and no notice shall be effective, unless and until delivered by
hand or by fax with confirmation of receipt by telephone to the recipient.

                   (iii)          ASSIGNMENT.  The rights of first refusal
provided by this Section 5.10 may be assigned by the Company, but only on a
case-by-case basis and only with


                                          32
<PAGE>

respect to specific shares following the occurrence of an event giving rise to a
right of first refusal with respect to such shares.

         5.11 LEGENDS.  Each certificate representing shares of Common Stock
acquired pursuant to the Convertible Secured Note, Option and Warrants may be
endorsed with the following legends, and any other legends required by law:

    THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
    THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, TRANSFERRED,
    ASSIGNED OR HYPOTHECATED UNLESS THERE IS AN EFFECTIVE REGISTRATION
    STATEMENT UNDER SUCH ACT COVERING SUCH SECURITIES, THE SALE IS MADE IN
    ACCORDANCE WITH RULE 144 UNDER THE ACT, OR THE COMPANY RECEIVES AN OPINION
    OF COUNSEL FOR THE HOLDER OF THESE SECURITIES REASONABLY SATISFACTORY TO
    THE COMPANY, STATING THAT SUCH SALE, TRANSFER, ASSIGNMENT OR HYPOTHECATION
    IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF
    SUCH ACT.

    UNTIL JUNE 17, 2002, THE SECURITIES EVIDENCED BY THIS CERTIFICATE ARE
    SUBJECT TO RESTRICTIONS ON TRANSFER, INCLUDING RIGHTS OF FIRST
    REFUSAL, SET FORTH IN AN AGREEMENT DATED AS OF JUNE 17, 1997, BY AND
    AMONG SUPERGEN, INC., TAKO VENTURES, LLC AND, SOLELY FOR PURPOSES OF
    SECTIONS 5.3 AND 5.5 THEREOF, LAWRENCE J. ELLISON, A COPY OF WHICH
    AGREEMENT MAY BE OBTAINED AT NO COST BY WRITTEN REQUEST MADE BY THE
    HOLDER OR RECORD OF THIS CERTIFICATE TO THE SECRETARY OF SUPERGEN,
    INC. AT SUPERGEN, INC.'S PRINCIPAL EXECUTIVE OFFICES.

The Company need not register a transfer of legended Securities, and may also
instruct its transfer agent not to register the transfer of the Securities,
unless the conditions specified in each of the foregoing legends are satisfied.
The first of the foregoing legends shall be removed from any security legended
pursuant to this Section 5.11, and the Company shall issue a certificate without
such legend to the holder of such Securities, if such Securities are registered
under the Securities Act and a prospectus meeting the requirements of Section 10
of the Securities Act is available or if such holder satisfies the requirements
of Rule 144(k), or the holder provides the Company with an opinion of counsel,
reasonably satisfactory to the Company, to the effect that (i) such holder meets
the requirements of Rule 144(k) or (ii) a public sale, transfer or assignment of
such Securities may be made without registration.  The second of the foregoing
legends shall be removed from any Security legended in accordance with this
Section 5.11, and the Company shall issue a certificate without such legend to
the holder of such Security, at the earlier of (i) such time as such Security is
transferred in accordance with Section 5.10 (other than Section 5.10(a)(ii)) and
(ii) five years from the date hereof.  The stop transfer instructions with
respect to any


                                          33
<PAGE>

legended Security shall be removed if both of the foregoing legends are removed
in accordance with this Section 5.11.

         5.12 INDEMNIFICATION.

              (a)  The Company shall indemnify and hold harmless Purchaser;
each person who controls Purchaser within the meaning of the Exchange Act
(including, without limitation, Cephalopod Corporation and Ellison); each of the
respective members, managers, partners, officers, directors, employees, agents
and affiliates of the foregoing; Purchaser Representative; and the Observer (the
"PURCHASER INDEMNITEES") from and against all actions, suits, claims,
proceedings, costs, damages judgments, amounts paid in settlement and expenses
(including, without limitations, attorneys' fees and disbursements) relating to
or arising out of any claim, demand or cause of action asserted by any third
party as a result of any of the transactions contemplated by this Agreement or
any of the other Transaction Documents (including without limitation acts or
omissions since the commencement of the negotiations leading to such
transactions); PROVIDED, HOWEVER, that the indemnification provided hereby shall
not extend to costs, damages, judgment, amounts paid in settlement and expenses
directly and primarily attributable to activities of a Purchaser Indemnitee
which do not involve any wrongful act or omission of the Company or any of its
directors (other than Ellison), officers, employees, agents or representatives.

              (b)  The Company shall reimburse the Purchaser Indemnitees for
all out-of-pocket expenses (including attorneys' fees and disbursements) as they
are incurred in connection with investigating, preparing to defend or defending
any such action, suit, claim or proceeding (including any inquiry or
investigation) whether or not a Purchaser Indemnitee is a party thereto.  If a
Purchaser Indemnitee makes a claim hereunder for payment or reimbursement of
expenses, such expenses shall be paid or reimbursed promptly upon receipt of
appropriate documentation relating thereto even if the Company reserves the
right to dispute whether this Agreement requires the payment or reimbursement of
such expenses.

              (c)  A Purchaser Indemnitee seeking indemnification hereunder
shall give written notice to the Company of any claim with respect to which it
seeks indemnification promptly after the discovery by such party of any matters
giving rise to a claim for indemnification; PROVIDED that the failure of any
Purchaser Indemnitee to give notice as provided herein shall not relieve the
Company of its obligations under this Section 5.12 unless the Company shall have
been materially prejudiced by the failure of Purchaser Indemnitee to make such
notification.  In case any such action, suit, claim or proceeding is brought
against Purchaser Indemnitee, the Company shall be entitled to participate in
the defense thereof and, to the extent that it may wish, to assume the defense
thereof, with counsel reasonably satisfactory to Purchaser Indemnitee, and after
notice from the Company of its election so to assume the defense thereof, the
Company will not be liable to such Purchaser Indemnitee under this Section 5.12
for any legal or other expense subsequently incurred by such Purchaser
Indemnitee in connection with the defense thereof; PROVIDED that (i) if the
Company shall elect not to assume the defense of such claim or action or (ii) if
Purchaser Indemnitee reasonably determines that there may be a conflict between
the positions of the Company and of Purchaser Indemnitee in defending such claim
or


                                          34
<PAGE>

action, then separate counsel shall be entitled to participate in and conduct
the defense, and the Company shall be liable for any legal or other expenses
incurred by Purchaser Indemnitee in connection with the defense; PROVIDED that
in no event shall be Company be required to pay the fees or expenses of more
than one counsel.  The Company shall not be liable for any settlement of any
action, suit, claim or proceeding effected without its written consent;
PROVIDED, however, that the Company shall not unreasonably withhold, delay or
condition its consent.  The Company further agrees that it will not, without
Purchaser Indemnitee's prior written consent, settle or compromise any claim or
consent to entry of any judgment in respect thereof in any pending or threatened
action, suit, claim or proceeding in respect of which indemnification may be
sought hereunder (whether or not any Purchaser Indemnitee is an actual or
potential party to such action, suit, claim or proceeding) unless such
settlement or compromise includes an unconditional release of Purchasers and
each other Purchaser Indemnitee from all liability arising out of such action,
suit, claim or proceeding.

              (d)  If the indemnification provided for in this Section 5.12 is
held by a court of competent jurisdiction to be unavailable to a Purchaser
Indemnitee with respect to any loss, liability, claim, damage, or expense
referred to therein, then the Company, in lieu of indemnifying such Purchaser
Indemnitee hereunder, shall contribute to the amount paid or payable by such
Purchaser Indemnitee as a result of such loss, liability, claim, damage, or
expense in such proportion as is appropriate to reflect the relative fault of
the Company on the one hand and of Purchaser Indemnitee on the other in
connection with the statements or omissions that resulted in such loss,
liability, claim, damage, or expense as well as any other relevant equitable
considerations.  The relative fault of the Company and of Purchaser Indemnitee
shall be determined by reference to, among other things, whether the untrue or
alleged untrue statement of a material fact or the omission to state a material
fact relates to information supplied by the Company or by Purchaser Indemnitee
and the parties' relative intent, knowledge, access to information, and
opportunity to correct or prevent such statement or omission.

              (e)  Notwithstanding the provisions of this Section 5.12, to the
extent that the provisions on indemnification and contribution contained in any
underwriting agreement contemplated in Article VI and entered into in connection
with an underwritten public offering thereunder are in conflict with the
foregoing provisions, the provisions in the underwriting agreement shall
control.

              (f)  The rights of Purchaser under this Section 5.12 shall be in
addition to any liability that the Company might otherwise have to Purchaser,
the Purchaser Representative and the Observer under this Agreement, at common
law or otherwise.

         5.13 FURTHER ASSURANCES.

              (a)  At any time or from time to time after the Note Closing and
each Option Closing and each exercise of the Warrants, each party shall execute
and deliver to the other party or parties such other documents and instruments,
provide such materials and information and take such other actions as either
party may reasonably request more effectively to carry out the provisions of
this Agreement and the other Transaction Documents.


                                          35
<PAGE>


                                      ARTICLE VI
                                 REGISTRATION RIGHTS

    Section 6.     REGISTRATION RIGHTS.

         6.1  DEFINITIONS.  For purposes of this Article VI:

              (a)  The term "HOLDER" means the Purchaser or any other person
who shall subsequently own or have the right to acquire Registrable Securities
or any assignee thereof in accordance with Section 6.12 hereof.


              (b)  The terms "REGISTER," "REGISTERED" and "REGISTRATION" refer
to a registration effected by preparing and filing a registration statement or
similar document in compliance with the Securities Act, and the declaration or
ordering of effectiveness of such registration statement or document.

              (c)  The term "REGISTRABLE SECURITIES" means (i) the shares of
Common Stock issued and sold by the Company pursuant to this Agreement
(including all shares issued by the Company upon conversion of the Convertible
Secured Note or exercise of the Option or any of the Warrants); (ii) any and all
shares of the Common Stock issued or issuable upon exercise, conversion, or
exchange of equity securities acquired by Purchaser pursuant to Section 5.1;
(iii) the Warrants; (vi) any and all shares of Common Stock issued or issuable
upon exercise of the Warrants; (v) stock issued in lieu thereof in any
reorganization, which has not been sold to the public; or (vi) stock issued in
respect of the stock referred to in (i), (ii), (iii) or (iv) as a result of a
stock split, stock dividend, recapitalization or the like, which has not been
sold to the public excluding in all cases, however, any of the foregoing sold by
a Holder pursuant to a registration statement under this Agreement, a
transaction pursuant to Rule 144 promulgated under the Securities Act, or sold
in any other transaction in which registration rights are not transferred
pursuant to Article VI hereof.

              (d)  The number of shares of "REGISTRABLE SECURITIES THEN
OUTSTANDING" shall be determined by the number of shares of Common Stock
outstanding which are, and the number of shares of Common Stock issuable
pursuant to then exercisable or convertible securities which are exercisable or
convertible into, Registrable Securities.

         6.2  REQUEST FOR REGISTRATION.

              (a)  If the Company shall receive at any time after the one 
year anniversary date of the Note Closing Date, a written request from one or 
more Holders representing at least 25% of the Registrable Securities then 
outstanding, that the Company file a registration statement under the 
Securities Act covering the registration with respect to all or a part of the 
Registrable Securities then outstanding, having an aggregate offering price, 
net of underwriting discounts and commissions, of at least $3,000,000, the 
Company shall, within fifteen 

                                      36
<PAGE>

(15) days of the receipt thereof, give written notice of such request to all 
Holders of Registrable Securities identified to the Company in accordance 
with Section 6.12 and shall, subject to the limitations of Section 6.2(d), 
file as soon as practicable, and in any event within one hundred twenty (120) 
days of the receipt of such request, a registration statement under the 
Securities Act covering all Registrable Securities which such Holders request 
to be registered within twenty (20) days of the mailing of such notice by the 
Company in accordance with Section 8.7 of this Agreement.  Any registration 
statement filed pursuant to under this Section 6.2 may, subject to the 
provisions of Section 6.2(b), include securities of the Company other than 
Registrable Securities.

              (b)  If the Holders of Registrable Securities initiating the
registration request pursuant to Section 6.2(a) ("INITIATING HOLDERS") intend to
distribute the Registrable Securities covered by their request by means of an
underwriting, they shall so advise the Company as a part of their request made
pursuant to this Section 6.2 and the Company shall include such information in
the written notice referred to in Section 6.2(a).  In such event, the right of
any such Holder to include such Holder's Registrable Securities in such
registration shall be conditioned upon such Holder's participation in such
underwriting and the inclusion of such Holder's Registrable Securities in the
underwriting (unless otherwise mutually agreed by a majority in interest of the
Initiating Holders and such Holder) to the extent provided herein.  All Holders
proposing to distribute their securities through such underwriting shall
(together with the Company as provided in Section 6.5(e)) enter into an
underwriting agreement in customary form with the underwriter or underwriters
selected for such underwriting by a majority in interest of the Initiating
Holders, which underwriter or underwriters shall be reasonably acceptable to the
Company.  If the Company, on its own behalf or on behalf of other holders of
securities other than Registrable Securities, requests inclusion in such
Registration, the Initiating Holders, to the extent they deem advisable and
consistent with the goals of such Registration, shall, on behalf of all Holders,
offer to include such securities other than Registrable Securities in the
underwriting (the "OTHER SECURITIES") and may condition such offer on the
acceptance by such persons of the terms of this Section 6.2.  In the event,
however, that the number of shares so included exceeds the number of shares of
Registrable Securities included by all Holders, such Registration shall be
treated as governed Section 6.3 hereof rather than Section 6.2, and it shall not
count as a Registration for purposes of Section 6.2 hereof.  Notwithstanding any
other provision of this Section 6.2, if the underwriter advises the Initiating
Holders in writing that marketing factors require a limitation of the number of
shares to be underwritten, then the Other Securities shall first be excluded
from such Registration to the extent required by such limitation.  If a further
limitation of the number of shares to be underwritten is still required, then
the Initiating Holders shall so advise all Holders of Registrable Securities
which would otherwise be underwritten pursuant hereto, and the number of shares
of Registrable Securities that may be included in the underwriting shall be
allocated among all Holders thereof, including the Initiating Holders, in
proportion (as nearly as practicable) to the amount of Registrable Securities
owned by each Holder.  If any Holder of Registrable Securities, or a holder of
other securities entitled (upon request) to be included in such Registration,
disapproves of the terms of the underwriting, such person may elect to withdraw
therefrom by written notice to the Company, the underwriter and the Initiating
Holders delivered at least seven (7) days prior to the effective date of the
Registration Statement.  The securities so withdrawn shall also be withdrawn
from the Registration Statement.


                                          37
<PAGE>

              (c)  The Company is obligated to effect only two (2)
registrations under this Section 6.2 and shall not be obligated to effect any
registrations under this Section 6.2 within one hundred twenty (120) days of the
effective date of any registration statement pertaining to securities of the
Company.

              (d)  Notwithstanding the foregoing, if the Company shall furnish
to the Initiating Holders a certificate signed by the President of the Company
stating that in the good faith judgment of the Board of Directors of the Company
it would be seriously detrimental to the Company and its shareholders for such
registration statement to be filed and it is therefore essential to defer the
filing of such registration statement, the Company shall have the right to defer
such filing for a period of not more than one hundred twenty (120) days after
receipt of the request of the Initiating Holders; PROVIDED, however, that the
Company may not utilize this right more than once in any twelve-month period.

         6.3  COMPANY REGISTRATION.

              (a)  If (but without any obligation to do so) the Company
proposes to register (including for this purpose a registration effected by the
Company for shareholders other than the Holders, but excluding a registration
relating to an aggregate of 409,200 shares of Common Stock and Warrants to
purchase Common Stock issued pursuant to a private placement effected in
December 1995 through March 1996) any of its Common Stock under the Securities
Act in connection with a secondary offering of such securities solely for cash
(other than a registration relating solely to the sale of securities to
participants in a Company stock option, stock purchase or similar plan, or a
registration relating solely to a transaction of the type described in
Rule 145(a) under the Securities Act), the Company shall, at such time, promptly
give each Holder written notice of such registration.  Upon the written request
of any Holder given within twenty (20) days after mailing of such notice by the
Company in accordance with Section 8.7 of this Agreement, the Company shall,
subject to the provisions of Section 6.3(b), include in such registration (and
any related qualification under blue sky laws or other compliance), and in any
underwriting involved therein, all of the Registrable Securities that each such
Holder has requested to be registered.

              (b)  In connection with any offering involving an underwriting of
shares being issued by the Company, the Company shall not be required under
Section 6.3 to include any Holder's securities in such underwriting unless such
Holder accepts the terms of the underwriting as agreed upon between the Company
and the underwriters selected by it, and then only in such quantity as will not,
in the opinion of the underwriters, jeopardize the success of the offering by
the Company.  If the total amount of securities, including Registrable
Securities, requested by shareholders to be included in such offering exceeds
the amount of securities sold other than by the Company that the underwriters
reasonably believe compatible with the success of the offering, then the Company
shall be required to include in the offering only that number of such
securities, including Registrable Securities, which the underwriters believe
will not jeopardize the success of the offering so long as all securities of all
other shareholders (including without limitation holders of registration rights)
but the Holders are excluded first.  If any Holder disapproves of the terms


                                          38
<PAGE>

of any such underwriting, it may elect to withdraw therefrom by written notice
to the Company and the underwriter delivered at lease seven (7) days prior to
the effective date of the Registration Statement.  Any Registrable Securities or
other securities excluded or withdrawn from such underwriting shall be withdrawn
from such registration.  The Holders shall have no right to participate in the
selection of the underwriters for an offering pursuant to Section 6.3.

              (c)  The Company shall have the right to terminate or withdraw
any registration initiated by it under this Section 6.3 prior to the
effectiveness of such registration whether or not any Holder has elected to
include securities in such registration.

         6.4  FORM S-3.  After the Company has qualified for the use of
Form S-3, in addition to the rights contained in the foregoing provisions of
this Article VI, one or more Holders shall have the right to request
registrations on Form S-3 (such requests shall be in writing and shall state the
number of shares of Registrable Securities to be disposed of and the intended
methods of disposition of such shares by Purchaser), PROVIDED, HOWEVER, that the
Company shall not be obligated to effect any such registration:  (a) if the
Holders, together with the holders of any other securities of the Company
entitled to inclusion in such registration, propose to sell Registrable
Securities and such other securities (if any) on Form S-3 at an aggregate price
to the public of less than $1,000,000; (b) in the event that the Company shall
furnish the certification described in Section 6.2(d) (but subject to the
limitations set forth therein); (c) in a given twelve-month period, after the
Company has effected two such registrations in any such period; or (d) within
one hundred twenty (120) days of the effective date of a Company registration
statement of the type described in Section 6.3.

         6.5  OBLIGATIONS OF THE COMPANY.  Whenever required under this
Agreement to effect the registration of any Registrable Securities, the Company
shall, as expeditiously as reasonably possible:

              (a)  prepare and file with the Commission a registration
statement with respect to such Registrable Securities and use its reasonable
best efforts to cause such registration statement to become effective, and, upon
the request of the Holders of a majority of the Registrable Securities
registered thereunder, keep such registration statement effective for up to one
hundred twenty (120) days;

              (b)  prepare and file with the Commission such amendments and
supplements to such registration statement and the prospectus used in connection
with such registration statement as may be necessary to comply with the
provisions of the Securities Act with respect to the disposition of all
securities covered by such registration statement;

              (c)  furnish to the Holders covered by such registration
statement such numbers of copies of a prospectus, including a preliminary
prospectus, in conformity with the requirements of the Securities Act, and such
other documents as they may reasonably request in order to facilitate the
disposition of such Registrable Securities;

              (d)  use its reasonable best efforts to register and qualify the
securities covered by such registration statement under such other securities or
Blue Sky laws of such


                                          39
<PAGE>

jurisdictions as shall be reasonably requested by the Holders thereof, PROVIDED
that (i) the Company shall not be required in connection therewith or as a
condition thereto to qualify to do business or to file a general consent to
service of process in any such states or jurisdictions and (ii) notwithstanding
anything in this Agreement to the contrary, in the event any jurisdiction in
which the securities shall be qualified imposes a non-waiveable requirement that
expenses incurred in connection with the qualification of the securities be
borne by selling shareholders, such expenses shall be payable pro rata by
selling shareholders;

              (e)  in the event of any underwritten public offering, enter into
and perform its obligations under an underwriting agreement, in usual and
customary form, with the managing underwriter of such offering.  Each Holder
participating in such underwriting shall also enter into and perform its
obligations under such an agreement;

              (f)  notify each Holder participating in the registration covered
by such registration statement at any time when a prospectus relating thereto is
required to be delivered under the Securities Act of the happening of any event
as a result of which the prospectus included in such registration statement, as
then in effect, includes an untrue statement of a material fact or omits to
state a material fact required to be stated therein or necessary to make the
statements therein not misleading in the light of the circumstances then
existing; in the event of a pending material event or transaction not publicly
disclosed by the Company, then upon written notice of such event or transaction,
each Holder shall suspend any sales or trades of the Company's securities under
any registration statement for up to thirty (30) days immediately following such
notice;

              (g)  cause all such Registrable Securities registered pursuant to
this Agreement to be listed on each securities exchange or national market
system on which similar securities issued by the Company are then listed or
traded;

              (h)  provide a transfer agent and registrar for all Registrable
Securities registered pursuant to such registration statement and a CUSIP number
for all such Registrable Securities, in each case not later than the effective
date of such registration;

              (i)  to the extent economically feasible, use its reasonable best
efforts to comply with all applicable rules and regulations of the SEC, and make
available to its security holders, as soon as reasonably practicable, an
earnings statement covering the period of at least twelve months, but not more
than eighteen (18) months, beginning with the first month after the effective
date of the Registration Statement, which earnings statement shall satisfy the
provisions of Section 11(a) of the Securities Act; and

              (j)  furnish, at the request of any Holder requesting
registration of Registrable Securities pursuant to this Agreement, on the date
that such Registrable Securities are delivered to the underwriters for sale in
connection with a registration pursuant to this Agreement, if such securities
are being sold through underwriters, or, if such securities are not being sold
through underwriters, on the date that the registration statement with respect
to such securities becomes effective, (i) an opinion, dated such date, of the
counsel representing the


                                          40
<PAGE>

Company for the purposes of such registration, in form and substance as is
customarily given to underwriters in an underwritten public offering, addressed
to the underwriters, if any, and to the Holders requesting registration of
Registrable Securities and (ii) a letter dated such date, from the independent
certified public accountants of the Company, in form and substance as is
customarily given by independent certified public accountants to underwriters in
an underwritten public offering, addressed to the underwriters, if any, and to
the Holders requesting registration of Registrable Securities.

         6.6  PROVISION OF INFORMATION.  It shall be a condition precedent to
the obligations of the Company to take any action pursuant to this Article VI
that the selling Holders shall furnish to the Company such information regarding
themselves, the Registrable Securities held by them, and the intended method of
disposition of such securities as shall be required to effect the registration
of the Registrable Securities.

         6.7  EXPENSES OF DEMAND REGISTRATION.  All expenses other than
underwriting discounts and commissions incurred in connection with
registrations, filings or qualifications pursuant to Section 6.2 and 6.4,
including (without limitation) all registration, filing and qualification fees,
printers' and accounting fees, fees and disbursements of counsel for the
Company, and the reasonable fees and disbursements of one counsel for the
participating Holders, shall be borne by the Company; PROVIDED, HOWEVER, that
the Company shall not be required to pay for any expenses of any registration
proceeding begun pursuant to Section 6.2 if the registration request is
subsequently withdrawn at the request of the Holders of a majority of the
Registrable Securities to be registered (in which case all participating Holders
shall bear such expenses); PROVIDED, HOWEVER, that if at the time of such
withdrawal, such Holders have learned of a material adverse change in the
condition, business or prospects of the Company from that known to such Holders
at the time of their request, then the Holders shall not be required to pay any
of such expenses and shall retain their rights pursuant to Section 6.2.

         6.8  EXPENSES OF COMPANY REGISTRATION.  The Company shall bear and pay
all expenses incurred in connection with any registration, filing or
qualification of Registrable Securities with respect to the registrations
pursuant to Section 6.3 for each Holder thereof (which right may be assigned as
provided in Section 6.12), including (without limitation) all registration,
filing and qualification fees, printers' and accounting fees relating or
apportionable thereto and the reasonable fees and disbursements of one counsel
for the participating Holders selected by a majority in interest thereof, but
excluding underwriting discounts and commissions relating to Registrable
Securities included in such registration.

         6.9  DELAY OF REGISTRATION.  No Holder shall have any right to obtain
or seek an injunction restraining or otherwise delaying any such registration as
the result of any controversy that might arise with respect to the
interpretation or implementation of this Agreement.

         6.10 INDEMNIFICATION.  In the event any Registrable Securities are
included in a registration statement under this Agreement:


                                          41
<PAGE>

              (a)  To the extent permitted by law, the Company will indemnify
and hold harmless each Holder of such Registrable Securities, the officers and
directors of each such Holder, any underwriter (as defined in the Securities
Act) for such Holder and each person, if any, who controls such Holder or
underwriter within the meaning of the Securities Act or the Exchange Act,
against any losses, claims, damages or liabilities (joint or several) to which
they may become subject under the Securities Act, the Exchange Act or other
federal or state law, insofar as such losses, claims, damages or liabilities (or
actions in respect thereof) arise out of or are based upon any of the following
statements, omissions or violations (collectively, a "VIOLATION"):  (i) any
untrue statement or alleged untrue statement of a material fact contained in
such registration statement, including any preliminary prospectus or final
prospectus contained therein or any amendments or supplements thereto, (ii) the
omission or alleged omission to state therein a material fact required to be
stated therein, or necessary to make the statements therein not misleading, or
(iii) any violation or alleged violation by the Company of the Securities Act,
the Exchange Act, any state securities law or any rule or regulation promulgated
under the Securities Act, the Exchange Act or any state securities law; and the
Company will reimburse each such Holder, officer or director, underwriter or
controlling person for any legal or other expenses reasonably incurred by them
in connection with investigating or defending any such loss, claim, damage,
liability or action; PROVIDED, HOWEVER, that the indemnity agreement contained
in this Section a shall not apply to amounts paid in settlement of any
such loss, claim, damage, liability or action if such settlement is effected
without the consent of the Company (which consent shall not be unreasonably
withheld or delayed), nor shall the Company be liable in any such case for any
such loss, claim, damage, liability or action to the extent that it arises out
of or is based upon a Violation which occurs in reliance upon and in conformity
with written information furnished expressly for use in connection with such
registration by any such Holder, officer, director, underwriter or controlling
person.

              (b)  To the extent permitted by law, each selling Holder will
indemnify and hold harmless the Company, each of its directors, each of its
officers who have signed the registration statement, each person, if any, who
controls the Company within the meaning of the Securities Act, any underwriter
and any other Holder selling securities in such registration statement or any of
its directors or officers or any person who controls such Holder, against any
losses, claims, damages or liabilities (joint or several) to which the Company
or any such director, officer, controlling person, or underwriter or controlling
person, or other such Holder or director, officer or controlling person may
become subject, under the Securities Act, the Exchange Act or other federal or
state law, insofar as such losses, claims, damages or liabilities (or actions in
respect thereto) arise out of or are based upon any Violation, in each case to
the extent (and only to the extent) that such Violation occurs in reliance upon
and in conformity with written information furnished by such Holder expressly
for use in connection with such registration; and each such Holder will
reimburse any legal or other expenses reasonably incurred by the Company or any
such director, officer, controlling person, underwriter or controlling person,
other Holder, officer, director, or controlling person in connection with
investigating or defending any such loss, claim, damage, liability, or action;
PROVIDED, HOWEVER, that the indemnity agreement contained in this
Section b shall not apply to amounts paid in settlement of any such loss,
claim, damage, liability or action if such settlement in effected without the
consent of the Holder from whom indemnification is sought (which consent shall
not be unreasonably withheld or delayed);


                                          42
<PAGE>

PROVIDED, that, in no event shall any indemnity under this Section b
exceed the gross proceeds from the offering received by such Holder.

              (c)  Promptly after receipt by an indemnified party under this
Section 6.10 of notice of the commencement of any action (including any
governmental action), such indemnified party will, if a claim in respect thereof
is to be made against any indemnifying party under this Section 6.10, deliver to
the indemnifying party a written notice of the commencement thereof and the
indemnifying party shall have the right to participate in, and, to the extent
the indemnifying party so desires, jointly with any other indemnifying party
similarly noticed, to assume the defense thereof with counsel mutually
satisfactory to the parties; PROVIDED, HOWEVER, that an indemnified party shall
have the right to retain its own counsel, with the fees and expenses to be paid
by the indemnifying party, if representation of such indemnified party by the
counsel retained by the indemnifying party would be inappropriate due to actual
or potential differing interests between such indemnified party and any other
party represented by such counsel in such proceeding.  The failure to deliver
written notice to the indemnifying party within a reasonable time of the
commencement of any such action, if prejudicial to its ability to defend such
action, shall relieve such indemnifying party of any liability to the
indemnified party under this Section 6.10, but the omission so to deliver
written notice to the indemnifying party will not relieve it of any liability
that it may have to any indemnified party otherwise than under this
Section 6.10.

              (d)  The obligations of the Company and Holders under this
Section 6.10 shall survive the completion of any offering of Registrable
Securities in a registration statement filed pursuant to this Agreement, and
otherwise.

         6.11 REPORTS UNDER THE EXCHANGE ACT.  With a view to making available
to the Holders the benefits of Rule 144 under the Securities Act and any other
rule or regulation of the Commission that may at any time permit a Holder to
sell securities of the Company to the public without registration, the Company
agrees to:

              (a)  make and keep public information available, as those terms
are understood and defined in Rule 144, at all times;

              (b)  file with the Commission in a timely manner all reports and
other documents required of the Company under the Securities Act and the
Exchange Act; and

              (c)  furnish to any Holder, so long as the Holder owns any
Registrable Securities, forthwith upon request (i) a written statement by the
Company that it has complied with the reporting requirements of Rule 144, the
Securities Act and the Exchange Act, (ii) a copy of the most recent annual or
quarterly report of the Company and such other reports and documents so filed by
the Company and (iii) such other information as may be reasonably requested in
availing any Holder of any rule or regulation of the Commission which permits
the selling of any such securities without registration.


                                          43
<PAGE>

         6.12 ASSIGNMENT OF REGISTRATION RIGHTS.  The rights to cause the
Company to register Registrable Securities pursuant to this Agreement may be
assigned by a Holder; PROVIDED, that within a reasonable time after such
transfer, the Company is furnished with written notice of the name and address
of such transferee or assignee and the securities with respect to which such
registration rights are being assigned; and PROVIDED, FURTHER, that such
assignment shall be effective only if immediately following such transfer the
further disposition of such securities by the transferee or assignee is
restricted under the Securities Act.  Any assignee or transferee asserting
rights under this Agreement shall be deemed to have consented to the terms and
conditions hereof.  Holders' rights to cause the Company to register their
Registrable Securities and to keep information available, granted to them by the
Company under this Article VI, may be assigned (or assigned in part and retained
in part) to one or more transferees or assignees who receive Registrable
Securities which, upon full exercise and conversion, represent the right to
obtain at least 250,000 shares of Registrable Securities (as adjusted for stock
dividends, stock split, recapitalizations and the like that occur after the date
of this Agreement), PROVIDED that (i) the Company is given written notice by
such Holder at the time of or within a reasonable time after said transfer or
assignment, stating the name and address of said transferee or assignee and
identifying the securities with respect to which such rights are being assigned,
and (ii) upon request by the Company, such permitted transferee or assignee
executes a counterpart to Article VI of this Agreement.

         6.13 "MARKET STAND-OFF" AGREEMENT.  Each Holder hereby agrees that it
shall not, to the extent requested by the Company and an underwriter of Common
Stock (or other securities) of the Company, sell, make short sale of, loan,
grant any option for the purchase of or otherwise transfer or dispose (other
than to donees who agree to be similarly bound) of any Registrable Securities
for a period of time, as agreed to by the Company and the underwriter not to
exceed one hundred eighty (180) days, following the effective date of a
registration statement of the Company filed under the Securities Act for an
offering in which the Holder participates; PROVIDED, HOWEVER, that all officers
and directors of the Company and all other persons with registration rights
(whether or not pursuant to this Agreement) except passive, outside investors
enter into similar agreements.

         6.14 TERMINATION OF REGISTRATION RIGHTS.  The Company's obligations
pursuant to this Agreement shall terminate as to any Holder of Registrable
Securities when the Holder can sell all of such Holder's Registrable Securities
pursuant to Rule 144(k) under the Securities Act and shall be suspended, but not
terminated, during any three-month period in which such Holder is entitled to
sell all shares issued or issuable to such Holder under Rule 144.

         6.15 NO INCONSISTENT AGREEMENTS.  The Company shall not on or after
the date of this Agreement enter into any agreement with respect to its
securities which is inconsistent with the rights granted to the Purchaser and
other Holders in this Article VI or otherwise conflicts with the provisions of
this Article VI.  The Company represents and warrants to Purchaser that the
rights granted to the Holders hereunder do not in any way conflict with and are
not inconsistent with any registration rights granted to any holders of the
Company's securities.


                                          44
<PAGE>

                                     ARTICLE VII
                                CONDITIONS TO CLOSINGS

    Section 7.     CONDITIONS TO CLOSING.

         7.1  CONDITIONS TO PURCHASER'S OBLIGATION TO ACQUIRE THE CONVERTIBLE
SECURED NOTE.  The obligation of Purchaser to purchase the Convertible Secured
Note hereunder is subject to the satisfaction, on or prior to the Note Closing
Date, of the following conditions, any of which may be waived by Purchaser, in
Purchaser's sole discretion, to the extent permitted by law:

              (a)  REPRESENTATIONS AND WARRANTIES CORRECT.  The representations
and warranties made by the Company in this Agreement and the other Transaction
Documents shall be true and correct in all material respects when made, and
shall be true and correct in all material respects on the Note Closing Date with
the same force and effect as if they had been made on and as of the Note Closing
Date, and the Company shall have delivered to Purchaser a certificate to such
effect, executed by the chief executive officer and chief financial officer of
the Company and dated the Note Closing Date.

              (b)  PERFORMANCE OF OBLIGATIONS.  The Company shall have
performed in all material respects all covenants, agreements and other
obligations required to be performed or observed by the Company pursuant to this
Agreement on or prior to the Note Closing Date, and the Company shall have
delivered to Purchaser a certificate to such effect, executed by the chief
executive officer and chief financial officer of the Company and dated the Note
Closing Date.

              (c)  ABSENCE OF MATERIAL ADVERSE EFFECT.  No Material Adverse
Effect shall have occurred, and there shall exist no fact or circumstance which
would reasonably be expected to result in a Material Adverse Effect.

              (d)  CONSENTS AND WAIVERS.  The Company shall have obtained all
consents, permits and waivers necessary for the consummation of the transactions
contemplated by this Agreement (including the transactions contemplated by the
other Transaction Documents).

              (e)  LEGAL INVESTMENT.  At the time of the Note Closing, the
issuance by the Company, and the acquisition by Purchaser, of the Convertible
Secured Note, Option and Warrants hereunder shall be legally permitted by all
laws and regulations to which Purchaser and the Company are subject, and no
preliminary or permanent injunction or other order by any court of competent
jurisdiction prohibiting or otherwise restraining such acquisition shall be in
effect.

              (f)  CERTAIN AGREEMENTS.  Joseph Rubinfeld, Ph.D., David M.
Fineman, Elliott Fineman and Greg Swendsen shall have executed and delivered to
Purchaser an agreement in substantially the form set forth in EXHIBIT F, each
other officer of the Company shall have executed and delivered to Purchaser an
agreement in substantially the form set forth in EXHIBIT G, and each such
agreement shall be in full force and effect.



                                          45
<PAGE>

              (g)  OPINION OF COMPANY'S COUNSEL.  Wilson Sonsini Goodrich &
Rosati, Professional Corporation, counsel to the Company, shall have delivered
an opinion addressed to Purchaser, dated the Note Closing Date, substantially in
the form as that attached hereto as EXHIBIT H.

         7.2  CONDITIONS TO COMPANY'S OBLIGATION TO ISSUE THE CONVERTIBLE
SECURED NOTE.  The Company's obligation to sell and issue the Convertible
Secured Note to Purchaser hereunder is subject to the satisfaction, on or prior
to the Note Closing Date, of the following conditions, any of which may be
waived by the Company, in its sole discretion, to the extent permitted by law:

              (a)  REPRESENTATIONS AND WARRANTIES CORRECT.  The representations
and warranties made by Purchaser in this Agreement shall be true and correct in
all material respects when made, and shall be true and correct in all material
respects on the Note Closing Date with the same force and effect as if they had
been made on and as of the Note Closing Date, and Purchaser shall have delivered
to the Company a certificate to such effect, executed by a duly authorized
member of Purchaser and dated the Note Closing Date.

              (b)  PERFORMANCE OF OBLIGATIONS.  Purchaser shall have performed
in all material respects all covenants, agreements and other obligations
required to be performed or observed by Purchaser pursuant to this Agreement on
or prior to the Note Closing Date, and Purchaser shall have delivered to the
Company a certificate to such effect, executed by a duly authorized member of
Purchaser and dated the Note Closing Date.

              (c)  LEGAL INVESTMENT.  At the time of the Note Closing, the
issuance by the Company, and the acquisition by Purchaser, of the Convertible
Secured Note, the Option and the Warrants hereunder shall be legally permitted
by all laws and regulations to which either Purchaser or the Company is subject,
and no preliminary or permanent injunction or other order by any court of
competent jurisdiction prohibiting or otherwise restraining such acquisition
shall be in effect.

         7.3  CONDITIONS TO ISSUANCE OF OPTION COMMON.  The consummation of
each Option Closing shall be subject to the condition (which may be waived by
Purchaser, in its sole discretion) that the Company shall have delivered to
Purchaser a certificate, executed by the chief executive officer and chief
financial officer of the Company, to the effect that the representations and
warranties of the Company set forth in this Agreement are true and complete in
all material respects on the Option Closing Date with the same force and effect
as if they had been made on and as of the Option Closing Date (except for
changes that could not reasonably be expected to have a Material Adverse Effect)
and that the Company has performed in all material respects the covenants,
agreements and other obligations that the Company is required to perform or
observe under this Agreement prior to the Option Closing Date.  The Company's
obligation to issue and deliver to Purchaser the Option Common is subject to the
satisfaction, on or prior to the applicable Option Closing Date, of the
following conditions, any of which may be waived by the Company, in its sole
discretion, to the extent permitted by law:


                                          46
<PAGE>

              (a)  all waiting periods, if any, under the HSR Act applicable to
the issuance of the shares of Option Common by the Company and the acquisition
of such shares by Purchaser hereunder shall have expired or been terminated;

              (b)  no preliminary or permanent injunction or other order by any
court of competent jurisdiction prohibiting or otherwise restraining such
issuance shall be in effect; and

              (c)  all consents, approvals, orders, authorizations and permits
of any federal, state, local or foreign governmental authority, if any, required
in connection with the issuance of the shares of Option Common by the Company
and the acquisition of such shares by Purchaser hereunder have been obtained.

              (d)  the representations and warranties made by Purchaser in
Section 4.3 of this Agreement shall be true and correct in all material respects
on and as of the Option Closing Date as if made on such date, and Purchaser
shall have delivered to the Company a certificate to such effect, executed by a
duly authorized member of Purchaser and dated the Option Closing Date.


                                     ARTICLE VIII
                                    MISCELLANEOUS

    Section 8.     MISCELLANEOUS.

         8.1  ACCESS TO INFORMATION. No information or knowledge obtained in
any investigation by Purchaser shall affect or be deemed to modify any
representation or warranty contained in this Agreement or the Transaction
Documents or the conditions to the respective obligations of the parties set
forth in Article VII.

         8.2  WAIVERS AND AMENDMENTS.  This Agreement or any provision hereof
may be amended, waived, discharged or terminated only by a statement in writing
signed by the party against which enforcement of the amendment, waiver,
discharge or termination is sought.

         8.3  GOVERNING LAW.  This Agreement shall be governed in all respects
by the internal laws of the State of California applicable to contracts to be
wholly performed therein, without respect to the conflicts or the laws or rules
thereof.

         8.4  SURVIVAL.  The representations, warranties, covenants and
agreements made in this Agreement shall survive the closings of the transactions
contemplated hereby, notwithstanding any investigation made by Purchaser.  All
statements as to factual matters contained in any certificate delivered by or on
behalf of the Company pursuant hereto or in connection with the transactions
contemplated hereby shall be deemed to be representations and warranties by the
Company hereunder as of the date of such certificate or instrument.


                                          47
<PAGE>

         8.5  SUCCESSORS AND ASSIGNS.  Except as expressly provided or
contemplated by this Agreement and the other Transaction Documents, neither this
Agreement nor any right, obligation or interest hereunder shall be assigned,
either in whole or in part, by any party hereto (other than by operation of law)
without the prior written consent of the other parties; PROVIDED, that nothing
herein shall prevent or limit the ability of Purchaser to assign any or all of
its rights under this Agreement or any of the other Transaction Documents to an
any majority-owned and controlled affiliate of Ellison.  Subject to the
foregoing limitations, the provisions hereof shall inure to the benefit of, and
be binding upon and enforceable by, the parties hereto and their respective
successors and assigns.

         8.6  ENTIRE AGREEMENT.  This Agreement, the other Transaction
Documents, and the other certificates and documents delivered pursuant hereto
constitute the full and entire understanding and agreement between the parties
with regard to the subjects hereof and supersede the Outline of Principal Terms
dated April 4, 1997 and all other prior and contemporaneous agreements,
understandings, negotiations and discussions, whether oral or written, of the
parties with respect thereto.

         8.7  NOTICES.  Except as provided in Section 5.10(b)(ii), all notices
and other communications required or permitted hereunder shall be in writing and
shall be delivered personally or by overnight courier or mailed by first class
mail, or Express Mail, postage prepaid, or via facsimile, addressed (a) if to
Purchaser or Ellison, to Tako Ventures, LLC, c/o Howson & Simon, 220 Montgomery
Street, Suite 1041, San Francisco, CA 94104, Attn:  Philip Simon, with copies of
said notice to be sent to Springs Rivin Detwiler Dudnick & Stikker, 351
California Street, Fifteenth Floor, San Francisco, CA 94104, Attn: Andrew
Dudnick, and Gray Cary Ware & Freidenrich, A Professional Corporation, 400
Hamilton Avenue, Palo Alto, CA 94301, Attn:  Rod J. Howard, Esq., and Brad J.
Rock, Esq., or to such other address (including electronic mail address) as
Purchaser or Ellison shall have furnished to the Company in writing or by
electronic mail, or (b) if to the Company, to SuperGen, Inc., Two Annabel Lane,
Suite 220, San Ramon, CA 94583, Attn: Dr. Joseph Rubinfeld, with a copy of any
said notice to be sent to Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road,
Palo Alto, California 94304-1050, Attn: Page Mailliard, Esq., or to such other
address (including electronic mail address) as the Company shall have furnished
to Purchaser and Ellison in writing or by electronic mail.  Except as provided
in Section 5.10(b)(ii), notices that are mailed by (i) first class mail shall be
deemed received three (3) business days after deposit in the mail and
(ii) Express Mail or overnight courier shall be deemed received one (1) business
day after deposit in the mail or delivery to such courier.  In the event that
the notice is sent by facsimile, notice shall be deemed to have been received
when sent and confirmed as to receipt.

         8.8  SEVERABILITY.  In case any provision of this Agreement shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions of this Agreement shall not in any way be affected or
impaired thereby.

         8.9  EXPENSES.  The Company shall reimburse Purchaser for all
(i) out-of-pocket expenses associated with this Agreement, the other Transaction
Documents and the transactions described herein and therein which are incurred
through or otherwise payable at


                                          48
<PAGE>

the Note Closing, including but not limited to travel and expenses associated
with Purchaser's due diligence, plus customary and reasonable legal fees and
expenses of Purchaser's counsel, and (ii) all filing fees and other
out-of-pocket expenses (whether incurred or payable before or after the Note
Closing), including but not limited to customary and reasonable legal fees and
expenses of counsel, in connection with any HRS filing(s) relating to the
transactions contemplated by this Agreement and the other Transaction Documents,
including any HSR filings required for Purchaser's exercise of the Option or
Warrants.  The foregoing reimbursement shall be in addition to, and not in
limitation of the payment of expenses provided by Sections 6.7 and 6.8 and any
other express obligation to pay or reimburse expenses provided by any other
provision of this Agreement or any of the other Transaction Documents.

         8.10 INTERPRETATION.  The table of contents and the titles of the
Articles and Sections of this Agreement are for convenience of reference only
and are not to be considered in construing this Agreement.  When reference is
made in this Agreement to an "article" or "Article" or to a "section" or
"Section", such reference shall be to an Article or a Section of this Agreement
unless otherwise specified.  Whenever the words "include", "includes", or
"including" are used in this Agreement they shall be deemed to be followed by
the words "without limitation."  The words "herein," "hereof" and words of
similar import refer to this Agreement as a whole, and not to any single
provision thereof.  In determining whether a given percentage of shares of
Common Stock is owned by Purchaser either on a "primary or fully diluted basis,"
Purchaser's ownership percentage on a primary basis shall be calculated on the
basis of the number of shares of Common Stock then owned by Purchaser, measured
as a percentage of the shares of Common Stock of the Company then outstanding,
and Purchaser's ownership percentage on a fully diluted basis shall be
calculated on the basis of the shares of Common Stock then owned by Purchaser,
together with the shares of Common Stock issuable upon conversion of the
then-unconverted portion of the Convertible Secured Note and the shares of
Common Stock then purchasable by Purchaser pursuant to the then-unexercised
portion of the Option and the Warrants, measured as a percentage of the shares
of Common Stock of the Company then outstanding together with the shares of
Common Stock then issuable under then-outstanding notes, options, warrants and
other securities of the Company which are convertible then or in the future into
Common Stock.

         8.11 COUNTERPARTS.  This Agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one instrument.

         8.12 DELAYS OR OMISSIONS.  No delay or omission to exercise any right,
power or remedy accruing to the Company or to Purchaser shall impair any such
right, power or remedy of the Company or Purchaser, nor shall it be construed to
be a waiver of any breach or default under this Agreement and the other
Transaction Documents, or an acquiescence therein or in any similar breach or
default thereafter occurring; nor shall any delay or omission to exercise any
right, power or remedy or any waiver of any single breach or default be deemed a
waiver of any other right, power or remedy or breach or default theretofore or
thereafter occurring.  All remedies, either under this Agreement and the other
Transaction Documents, or by law otherwise afforded to the Company or Purchaser,
shall be cumulative and not alternative.


                                          49
<PAGE>

    IN WITNESS WHEREOF, Purchaser, the Company and, solely with respect to
Sections 5.3 and 5.5 of the Agreement, Ellison have caused this Agreement to be
duly executed as of the date and year first above written.

                                          SUPERGEN, INC.


                                          By:  /s/ Dr. Joseph Rubinfeld
                                               ------------------------
                                               Name:  Dr. Joseph Rubinfeld
                                               Title: Chief Executive Officer
                                                      President and Chief
                                                      Executive Officer

                                              TAKO VENTURES, LLC

                                          By   CEPHALOPOD CORPORATION,
                                               Member


                                          By:  /s/ Lawrence J. Ellison
                                               ------------------------
                                               Lawrence J. Ellison
                                               Chief Executive Officer




                                               /s/ Lawrence J. Ellison
                                               ------------------------
                                               LAWRENCE J. ELLISON

                                      50


<PAGE>


                      CONVERTIBLE SECURED PROMISSORY NOTE
                      -----------------------------------

$15,300,000                                 June 17, 1997

     FOR VALUE RECEIVED, the undersigned, SUPERGEN, INC., a California 
corporation ("BORROWER"), hereby promises to pay to TAKO VENTURES, LLC, a 
California limited liability company, or order ("LENDER"), Fifteen Million 
Three Hundred Thousand Dollars ($15,300,000), as provided herein.

     This Note is issued pursuant to the Convertible Secured Note, Option and 
Warrant Purchase Agreement, dated as of the date hereof, by and among 
Borrower, Lender and, solely for the purposes of Sections 5.3 and 5.5 
thereof, Lawrence J. Ellison (the "PURCHASE AGREEMENT").  Capitalized terms 
used herein without definition shall have the meanings ascribed to them in 
the Purchase Agreement.

A.   PAYMENT SCHEDULE.

     1.   PRINCIPAL.  The principal indebtedness shall be payable in 
full upon Lender's delivery of a Notice of Demand prior to the Conversion 
Time in accordance with the terms of Section 1.1 of the Purchase Agreement.  
If a timely Notice of Demand is not given and this Note is not fully 
converted into shares of Common Stock of the Borrower in accordance with 
Section 1.1 of the Purchase Agreement because any applicable waiting period 
under the Hart-Scott-Rodino Antitrust Improvements Act of 1975, as amended 
(the "HSR ACT") shall not have expired or been terminated or any required 
regulatory approval shall not have been received, then on the Option 
Termination Date the principal indebtedness outstanding shall be payable in 
full in accordance with Section 1.1 of the Purchase Agreement.

     2.   PREPAYMENT.  Borrower shall have not have any right to prepay, 
in whole or in part, the principal of this Note.

     3.   FORM OF PAYMENT.  Principal and all other amounts due 
hereunder are to be paid in lawful money of the United States of America in 
federal or other immediately available funds.

B.   CONVERSION.  In the event that a Notice of Demand is not given 
prior to the Conversion Time as provided in Section 1.1 of the Purchase 
Agreement, then the outstanding unpaid principal hereunder shall be 
converted, in whole or in part, to the maximum extent permitted under the HSR 
Act and any other applicable laws, effective at the Conversion Time, into 
fully paid and nonassessable shares of Common Stock of Borrower in accordance 
with the terms and conditions of Section 1.1 of the Purchase Agreement.

<PAGE>

C.   SECURITY INTEREST.  Borrower's obligations hereunder are secured by 
the Collateral, as defined in the Pledge and Security Agreement, dated as of 
the date hereof, by and between Borrower and Lender (the "SECURITY 
AGREEMENT").

D.   EVENTS OF DEFAULT.

     1.    DEFINITION OF EVENT OF DEFAULT.  The occurrence of any one or 
more of the following events on or after the Conversion Time shall constitute 
an "EVENT OF DEFAULT" hereunder:

                  (i)   any failure by Borrower to pay any amount payable, or 
to issue any securities issuable, hereunder in accordance with the terms 
hereof;

                  (ii)  subjection of the Collateral to levy of execution or 
other judicial process; or

                  (iii) Borrower's institution of proceedings against it, or 
Borrower's filing of a petition or answer or consent seeking reorganization 
or release, under the federal Bankruptcy Code, or any other applicable 
federal or state law relating to creditor rights and remedies, or Borrower's 
consent to the filing of any such petition or the appointment of a receiver, 
liquidator, assignee, trustee or other similar official of Borrower or of any 
substantial part of its property, or Borrower's making of an assignment for 
the benefit of creditors, or the taking of corporate action in furtherance of 
such action.

     2.    RIGHTS AND REMEDIES ON EVENT OF DEFAULT. During the 
continuance of an Event of Default, Lender shall have the right (i) to 
accelerate the payment of the principal, interest and charges owing hereunder 
and (ii) to enforce this Note by exercise of the rights and remedies granted 
to it by applicable law or under the Transaction Documents.

E.   OTHER PROVISIONS.

     1.    NOTICES.  All notices and other communications required or 
permitted hereunder shall be in writing and shall be delivered personally or 
by overnight courier or mailed by first class mail, or Express Mail, postage 
prepaid, or via facsimile, delivered as follows:

     (i)   if to Lender, to:

           Tako Ventures, LLC,
           c/o Philip Simon 
           Howson & Simon CPAs L.P.  
           220 Montgomery Street
           Suite 1041
           San Francisco, CA 94104

                                       2 
<PAGE>

           with copies to:

           Springs, Rivin, Detwiler, Dudnick & Stikker
           351 California Street   
           Suite 1041 
           San Francisco, CA 94104
           Attention:  Andy Dudnick, Esq.

           Gray Cary Ware & Freidenrich
           A Professional Corporation
           400 Hamilton Avenue
           Palo Alto, CA 94301
           Attention:  Rod J. Howard, Esq. & Brad J. Rock, Esq.

           or at such other address as Lender shall have furnished to Borrower 
           in writing,

     (ii) if to Borrower, to:

           SuperGen, Inc.
           Two Annabel Lane, Suite 220 
           San Ramon, CA 94583

           with a copy to:

           Wilson Sonsini Goodrich & Rosati, 
           Professional Corporation
           650 Page Mill Road
           Palo Alto, California 94304-1050
           Attn: John V. Roos, Esq. and Page Mailliard, Esq.

           or at such other address as Borrower shall have furnished to Lender 
           in writing.

Notices that are mailed by (i) first class mail shall be deemed received 
three (3) business days after deposit in the mail and (ii) Express Mail or 
overnight courier shall be deemed received one (1) business day after deposit 
in the mail.  In the event that the notice is sent by facsimile, notice shall 
be deemed to have been received when sent and confirmed as to receipt.

     2.    LENDER'S RIGHTS; BORROWER WAIVERS.  Lender's acceptance of 
partial or delinquent payment from Borrower hereunder, or Lender's failure to 
exercise any right hereunder, shall not constitute a waiver of any obligation 
of Borrower hereunder, or any right of Lender hereunder, and shall not affect 
in any way the right to require full performance at any time thereafter.   
Borrower waives presentment, diligence, demand of payment, notice, protest 
and all other demands

                                       3 
<PAGE>

and notices in connection with the delivery, acceptance, performance, default 
or enforcement of this Note and, to the greatest extent permitted by law, 
Borrower waives any defense based upon any statutes of limitation.  In any 
action on this Note, Lender need not produce or file the original of this 
Note, but need only file a photocopy of this Note certified by Lender be a 
true and correct copy of this Note in all material respects.

     3.    ENFORCEMENT COSTS.  Borrower shall pay all costs and expenses, 
including, without limitation, reasonable attorneys' fees and expenses Lender 
expends or incurs in connection with the enforcement of this Note, the 
collection of any sums due hereunder, any actions for declaratory relief in 
any way related to this Note, or the protection or preservation of any rights 
of Lender hereunder, including all costs and expenses incurred during a 
bankruptcy or similar proceeding of Borrower.

     4.    SEVERABILITY.  Whenever possible each provision of this Note 
shall be interpreted in such manner as to be effective and valid under 
applicable law, but if any provision is prohibited by or invalid under 
applicable law, it shall be ineffective to the extent of such prohibition or 
invalidity, without invalidating the remainder of the provision or the 
remaining provisions of this Note.

     5.    AMENDMENT PROVISIONS.  This Note may not be amended or 
modified, nor may any of its terms be waived, except by written instruments 
signed by Borrower and Lender.

     6.    BINDING EFFECT.  This Note shall be binding upon, and shall 
inure to the benefit of, Borrower and Lender and their respective successors 
and assigns; PROVIDED, HOWEVER, that Borrower's rights and obligations shall 
not be assigned or delegated without Lender's prior written consent, given in 
its sole discretion, and any purported assignment or delegation without such 
consent shall be void AB INITIO.

     7.    TIME OF ESSENCE.  Time is of the essence of each and every 
provision of this Note.

     8.    HEADINGS.  Section headings used in this Note have been set 
forth herein for convenience of reference only.  Unless the contrary is 
compelled by the context, everything contained in each section hereof applies 
equally to this entire Note.

                                  SUPERGEN, INC.

                                  By /s/ Dr. Joseph Rubinfeld
                                      ------------------------

                         Name:    Dr. Joseph Rubinfeld                     
                         Title:   Chief Executive Officer, President and 
                                     Chief Scientific Officer

                                       4 

<PAGE>

THE SECURITY EVIDENCED BY THIS WARRANT AND THE SECURITIES TO BE PURCHASED UNDER
THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED, AND MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED UNLESS THERE IS AN
EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT COVERING SUCH SECURITIES, THE
SALE, TRANSFER OR ASSIGNMENT IS MADE IN ACCORDANCE WITH RULE 144 UNDER THE ACT,
OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES
REASONABLY SATISFACTORY TO THE COMPANY, STATING THAT SUCH SALE, TRANSFER OR
ASSIGNMENT IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS
OF SUCH ACT.

THE SECURITY EVIDENCED BY THIS WARRANT AND THE SECURITIES TO BE PURCHASED UNDER
THIS WARRANT ARE SUBJECT TO RESTRICTIONS ON TRANSFER, INCLUDING RIGHTS OF FIRST
REFUSAL SET FORTH IN A CONVERTIBLE SECURED NOTE, OPTION AND WARRANT PURCHASE
AGREEMENT DATED JUNE 17, 1997, BY AND AMONG SUPERGEN, INC., TAKO VENTURES, LLC
AND, SOLELY FOR PURPOSES OF SECTIONS 5.3 AND 5.5 THEREOF, LAWRENCE J. ELLISON, A
COPY OF WHICH AGREEMENT MAY BE OBTAINED AT NO COST BY WRITTEN REQUEST MADE BY
THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE SECRETARY OF SUPERGEN, INC. AT
SUPERGEN, INC.'S PRINCIPAL EXECUTIVE OFFICES.

No. 1                                               Right to Purchase 500,000
June 17, 1997                                          Shares of Common Stock
Void after June 17, 2007


                                    SUPERGEN, INC.

                        SERIES 1 COMMON STOCK PURCHASE WARRANT
                                   (Non-redeemable)

    SuperGen, Inc., a California corporation (the "Company"), hereby certifies
that, for good and valuable consideration, Tako Ventures, LLC, a California
limited liability company (the "Warrant Holder"), is entitled, subject to the
terms set forth below, to purchase from the Company at any time during the
period commencing at 10:00 a.m. on June 17, 1997 and ending on the earlier of
(i) the delivery of any Notice of Demand pursuant to that certain Convertible
Secured Note, Option and Warrant Purchase Agreement by and among the Company,
Tako Ventures, LLC and, solely for purposes of Sections 5.3 and 5.5 thereof,
Lawrence J. Ellison dated as of June 17, 1997 (the "Purchase Agreement") and
(ii) 5:00 p.m., Pacific Time, on June 17, 2007 (the "Exercise Period"), up to
the number of fully-paid and non-assessable shares of Common Stock of the
Company set forth in Section 1 below for the price per share set forth in
Section 2 below, subject to adjustment as herein provided.


                                          1
<PAGE>

    1.   NUMBER OF SHARES.  Subject to adjustment as provided in Section 8
below, this Warrant shall be exercisable for Five Hundred Thousand (500,000)
shares of Common Stock of the Company, par value $0.001 (the "Shares").

    2.   EXERCISE PRICE.  This Warrant shall be exercisable at a price (the
"Exercise Price") equal to Thirteen Dollars and Fifty Cents ($13.50) per Share,
in U.S. dollars, subject to adjustment as provided in Section 8 below.

    3.   REDEMPTION BY THE ISSUER.  This Warrant is not subject to redemption
by the Company.

    4.   EXERCISE OR CONVERSION OF WARRANT.

         4.1.  EXERCISE.  During the Exercise Period, this Warrant may be
exercised in whole or in part by the Warrant Holder by executing and delivering
to the Company at its principal office the written notice of exercise in the
form attached hereto as EXHIBIT W-1, specifying the portion of the Warrant to be
exercised and accompanied by this Warrant, and paying to the Company the amount
obtained by multiplying the number of Shares designated in the notice of
exercise by the Exercise Price, as then in effect, in cash (in immediately
available funds) or, where permitted by law, by cancellation of indebtedness of
the Company to the Warrant Holder, or by surrender of shares of the Company's
Common Stock that are clear of all liens, claims, encumbrances or security
interests.  Cash used in payment of some or all of the purchase price of any
exercise hereunder, if in an amount in excess of One Hundred Thousand Dollars
($100,000), shall be by wire transfer of immediately available funds payable to
the order of the Company.

         4.2.  CONVERSION.  In lieu of exercising this Warrant or any portion
hereof, the Warrant Holder shall have the right to convert this Warrant or any
portion hereof during the Exercise Period into shares of Common Stock by
executing and delivering to the Company at its principal office the written
notice of conversion in the form attached hereto as EXHIBIT W-1, specifying the
portion of the Warrant to be converted, and accompanied by this Warrant.  The
number of Shares to be issued upon such conversion shall be that number of
Shares equal to the quotient obtained by dividing (x) the value of the converted
portion of the Warrant at the time the conversion right is exercised (determined
by subtracting the aggregate Exercise Price for the Shares represented by the
portion of the Warrant to be converted from the Fair Market Value of such Shares
at the time of conversion) by (y) the Fair Market Value of one Share at such
time.  As used herein, "FAIR MARKET VALUE" means, as of any date, the value of a
share of the Company's Common Stock determined as follows:

               (a) if such Common Stock is then quoted on The Nasdaq
National Market, the simple average of the closing sale prices as reported on
The Nasdaq National Market for the ten (10) consecutive trading days prior to
such date;

               (b) if such Common Stock is publicly traded and is then
listed on a national securities exchange, the simple average of the closing sale
prices on the principal national


                                          2
<PAGE>

securities exchange on which the Common Stock is listed or admitted to trading
for the ten (10) consecutive trading days prior to such date;

               (c) if such Common Stock is publicly traded but is not
quoted on The Nasdaq National Market nor listed or admitted to trading on a
national securities exchange, the simple average of the closing bid prices for
the ten (10) consecutive trading days prior to such date, as reported by The
Wall Street Journal or other widely available reporting source, for the
over-the-counter market; or

               (d) if none of the foregoing is applicable, by the Board of
Directors of the Company in good faith.

Any portion of this Warrant that is converted shall be immediately canceled.

         4.3.  INVESTMENT LETTER.  Upon exercise or conversion of the Warrant
in accordance with Sections 4.1 or 4.2 hereof, the Warrant Holder shall either
(i) execute and deliver to the Company an investment letter in the form attached
hereto as EXHIBIT W-2 or (ii) deliver to the Company an opinion of counsel for
the Warrant Holder reasonably satisfactory to the Company, stating that such
exercise or conversion is exempt from the registration and prospectus delivery
requirements of such the Securities Act of 1933, as amended (the "Securities
Act").

         4.4.  LIMITATION ON EXERCISE OR CONVERSION.  Notwithstanding
Sections 4.1 and 4.2 and any other provisions of this Warrant, the Warrant
Holder's rights to obtain shares of Common Stock (or other voting securities
that the Warrant Holder may otherwise become entitled to receive in accordance
with Section 8 below) upon exercise or conversion of this Warrant shall be
subject to the expiration or early termination of any applicable waiting periods
relating to the acquisition of such securities by the Warrant Holder under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and, if
applicable, shall be subject to and limited by the provisions set forth in
Section 5.5 of the Purchase Agreement.

    5.   DELIVERY OF STOCK CERTIFICATES, ETC.  As soon as practicable after the
exercise or conversion of this Warrant (in full or in part) in accordance with
Section 4 above, the Company at its expense will cause to be issued in the name
of and delivered to the Warrant Holder (i) a certificate or certificates for the
number of fully paid and nonassessable Shares to which the Warrant Holder shall
be entitled upon such exercise or conversion and (ii) a new Warrant of like
tenor to purchase all of the Shares that may be purchased pursuant to the
portion, if any, of the Warrant not exercised or converted by the Warrant
Holder.  The Warrant Holder shall for all purposes be deemed to have become the
holder of record of such Shares at the close of business on the date on which
this Warrant was surrendered together with a notice of exercise or conversion
and, in the case of exercise, payment of the Exercise Price was made,
irrespective of the date of delivery of such certificate or certificates, except
that, if the date of such surrender, notice and payment is a date when the stock
transfer books of the Company are closed, the Warrant Holder shall be deemed to
have become the holder of record of such Shares at the close of business on the
next succeeding date on which the stock transfer books are open.


                                          3
<PAGE>

    6.   COVENANTS AS TO COMMON STOCK.  The Company covenants and agrees that
all the Shares will, upon issuance, be validly issued and outstanding, fully
paid and nonassessable, with no personal liability attaching to the ownership
thereof, and free from all taxes, liens and charges with respect to the issuance
thereof.  The Company further covenants and agrees that the Company will at all
times have authorized and reserved, and free from preemptive rights, a
sufficient number of shares of Common Stock to provide for the exercise of the
rights represented by this Warrant

    7.   REGISTRATION RIGHTS.  This Warrant and the Shares issued or issuable
upon the exercise or conversion of this Warrant are subject to registration in
accordance with the registration rights in favor of the Warrant Holder as
provided for in Article VI of the Purchase Agreement.

    8.   ADJUSTMENTS.

         8.1.  In the event that the Company shall (i) pay a dividend in, or
make a distribution of, shares of capital stock or other securities (including,
without limitation, any rights or options to subscribe to or purchase any
additional shares of any class of its capital stock, any evidence of its
indebtedness or assets, or any other rights or options) on its outstanding
Common Stock, (ii) subdivide its outstanding shares of Common Stock into a
greater number of such shares or (iii) combine its outstanding shares of Common
Stock into a smaller number of such shares, the total number of Shares
purchasable upon the exercise of this Warrant shall be adjusted so that upon the
subsequent exercise of this Warrant, the Warrant Holder shall be entitled to
receive at the same aggregate Exercise Price the number of shares of capital
stock and other securities (of one or more classes) which such holder would have
owned or would have been entitled to receive immediately following the happening
of any of the events described above had this Warrant been exercised in full
immediately prior to the record date with respect to such event.  Any adjustment
made pursuant to this Section shall, in the case of a dividend or distribution
of stock or other securities, become effective as of the record date therefor
and, in the case of a subdivision or combination, be made as of the effective
date thereof.  If, as a result of an adjustment made pursuant to this Section,
the Warrant Holder shall become entitled to receive shares or other units of two
or more classes of capital stock or other securities of the Company upon a
subsequent exercise hereof, the Board of Directors of the Company (whose
reasonable determination shall be conclusive and, upon request by the Warrant
Holder, shall be evidenced by a certified Board resolution delivered to the
Warrant Holder) shall determine the allocation of the adjusted Exercise Price
between or among shares of such classes of capital stock.  The above provisions
of this Section 8.1 shall apply similarly to successive stock dividends,
subdivisions and combinations.

         8.2.  In the event of a capital reorganization or a reclassification
of the Common Stock (except as provided in Section 8.1 above or Section 8.4
below), any Warrant Holder, upon exercise of this Warrant, shall be entitled to
receive, in substitution for the Common Stock to which it would have become
entitled upon exercise immediately prior to such reorganization or
reclassification, the shares (of any class or classes) or other securities or
property of the Company (or cash) that it would have been entitled to receive at
the same aggregate Exercise Price upon such reorganization or reclassification
if this Warrant had been exercised immediately prior to the


                                          4
<PAGE>

record date with respect to such event; and in any such case, appropriate
provision (as determined by the Board of Directors of the Company, whose
reasonable determination shall be conclusive and, upon request by the Warrant
Holder, shall be evidenced by a certified Board resolution delivered to the
Warrant Holder) shall be made for the application of this Section 8.2 with
respect to the rights and interests thereafter of the Warrant Holder (including
but not limited to the allocation of the Exercise Price between or among shares
of classes of capital stock or other securities), to the end that this
Section 8.2 (including the adjustments of the number of shares of Common Stock
or other securities purchasable and the Exercise Price thereof) shall thereafter
be reflected, as nearly as reasonably practicable, in all subsequent exercises
of this Warrant for any shares or securities or other property (or cash)
thereafter deliverable upon the exercise hereof.  The above provisions of this
Section 8.2 shall apply similarly to successive reorganizations or
recapitalizations.

         8.3.  Whenever the number of shares of Common Stock or other
securities purchasable upon exercise of this Warrant is adjusted as provided in
this Section 8, the Company will promptly deliver to the Warrant Holder a
certificate signed by a Chairman or co-Chairman of the Board or the President or
a Vice President of the Company and by the Treasurer or an Assistant Treasurer
or the Secretary or an Assistant Secretary of the Company setting forth the
number and kind of securities or other property purchasable upon exercise of
this Warrant, as so adjusted, stating that such adjustments in the number or
kind of shares or other securities or property conform to the requirements of
this Section 8, and setting forth a brief statement of the facts accounting for
such adjustments; PROVIDED, HOWEVER, that failure to deliver any notice required
under this Section 8.3, or any defect therein, shall not affect the legality or
validity of any such adjustments under this Section 8; and PROVIDED, FURTHER,
that, where appropriate, such notice may be given in advance and included as
part of the notice required to be given pursuant to Section 9 hereof.

         8.4.  In the event of any consolidation or share exchange
reorganization of the Company with, or merger of the Company into, another
corporation (other than a consolidation, share exchange information or merger
which does not result in any reclassification or change of the outstanding
Common Stock), or in case of any sale or conveyance to another corporation of
the property of the Company as an entirety or substantially as an entirety, the
entity formed by such consolidation, share exchange reorganization or merger or
the person which shall have acquired such property, as the case may be, shall
execute and deliver to the Warrant Holder a new warrant providing that the
Warrant Holder shall have the right thereafter (until the expiration of this
Warrant) to receive, upon exercise of such warrant, solely the kind and amount
of shares of stock and other securities and property (or cash) receivable upon
such consolidation, share exchange reorganization, merger, sale or transfer by a
holder of the number of shares of Common Stock of the Company for which this
Warrant might have been exercised immediately prior to such consolidation, share
exchange reorganization, merger, sale or transfer.  Such new warrant shall
provide for adjustments which shall be as nearly equivalent as may be
practicable to the adjustments provided in this Section 8.4.  The above
provision of this Section 8.4 shall similarly apply to successive
consolidations, share exchange reorganizations, mergers, sales or transfers.

         8.5.  Irrespective of any adjustments in the number or kind of shares
or other securities or property issuable upon exercise of this Warrant, this
Warrant and any replacement or


                                          5
<PAGE>

balance Warrants thereafter issued may continue to express the same price and
number and kind of shares as are stated in the original Warrant.

         8.6.  The Company may retain a firm of independent public accountants
of recognized standing, which may be the firm regularly retained by the Company,
selected by the Board of Directors of the Company or the Executive Committee of
said Board, to make any computation required under this Section 8, and a
certificate signed by such firm shall, in the absence of fraud or gross
negligence, be conclusive evidence of the correctness of any computation made
under this Section 8.

         8.7.  For the purpose of this Section 8, the term "Common Stock"
shall mean (i) the class of stock designated as Common Stock in the Restated
Articles of Incorporation of the Company, as amended, at the date of this
Warrant, or (ii) any other class of stock resulting from successive changes or
reclassifications of such Common Stock consisting solely of changes in par
value, or from par value to no par value, or from no par value to par value.  In
the event that at any time as a result of an adjustment made pursuant to this
Section 8, the Warrant Holder shall become entitled to receive any shares of
capital stock of the Company other than shares of Common Stock, thereafter the
number of such other shares so receivable upon exercise of this Warrant shall be
subject to adjustment from time to time in a manner and on terms as nearly
equivalent as practicable to the provisions with respect to the Common Stock
contained in this Section 8, and all other provisions of this Warrant, with
respect to the Common Stock, shall apply on like terms to any such other shares.

         8.8.  The Company may, from time to time and to the extent permitted
by law, reduce the exercise price of this Warrant by any amount for a period of
not less than twenty (20) days.  If the Company so reduces the exercise price of
this Warrant, it will give the Warrant Holder not less than fifteen (15) days'
notice of such decrease, and shall take such other steps as may be required
under applicable law in connection with any offers or sales of securities at the
reduced price.

         8.9.  Whenever the number of Shares purchasable upon the exercise of
this Warrant is adjusted as provided in Section 8, the Exercise Price for each
Share payable upon exercise shall be adjusted by multiplying such Exercise Price
immediately prior to such adjustment by a fraction, the numerator of which shall
be the number of Shares purchasable upon the exercise of the Warrant immediately
prior to such adjustment, and the denominator of which shall be the number of
Shares so purchasable immediately thereafter.

    9.   NOTICE OF CERTAIN CORPORATE ACTIONS.  In case the Company after the
date hereof shall propose (i) to offer to the holders of Common Stock,
generally, rights to subscribe to or purchase any additional shares of any class
of its capital stock, any evidences of its indebtedness or assets, or any other
rights or options or (ii) to effect any reclassification of Common Stock (other
than a reclassification involving merely the subdivision or combination of
outstanding shares of Common Stock) or any capital reorganization, or any
consolidation or merger to which the Company is a party and for which approval
of any stockholders of the Company is required, or any sale, transfer or other
disposition of its property and assets substantially as an entirety, or the
liquidation, voluntary or involuntary dissolution or winding-up of the Company,
then, in each


                                          6
<PAGE>

such case, the Company shall deliver to the Warrant Holder notice of such
proposed action, which notice shall specify the date on which the books of the
Company shall close or a record be taken for such offer of rights or options, or
the date on which such reclassification, reorganization, consolidation, merger,
sale, transfer, other disposition, liquidation, voluntary or involuntary
dissolution or winding-up shall take place or commence, as the case may be, and
which shall also specify any record date for determination of holders of Common
Stock entitled to vote thereon or participate therein and shall set forth such
facts with respect thereto as shall be reasonably necessary to indicate any
adjustments in the Exercise Price and the number or kind of shares or other
securities purchasable upon exercise of the Warrant which will be required as a
result of such action.  Such notice shall be sent, in the case of any action
covered by clause (i) above, at least ten (10) days prior to the record date for
determining holders of the Common Stock for purposes of such action or, if a
record is not to be taken, the date as of which the holders of shares of Common
Stock of record are to be entitled to such offering; and, in the case of any
action covered by clause (ii) above, at least twenty (20) days prior to the
earlier of the date on which such reclassification, reorganization,
consolidation, merger, sale, transfer, other disposition, liquidation, voluntary
or involuntary dissolution or winding-up is expected to become effective and the
date on which it is expected that holders of shares of Common Stock of record on
such date shall be entitled to exchange their shares for securities or other
property deliverable upon such reclassification, reorganization, consolidation,
merger, sale, transfer, other disposition, liquidation, voluntary or involuntary
dissolution or winding-up.

    10.  TAXES.  The Company shall pay all documentary, stamp or other
transactional taxes attributable to the issuance or delivery of shares of
capital stock or other securities of the Company upon the exercise hereof.

    11.  NO FRACTIONAL INTERESTS.  The Company shall not be required to issue
any replacement or balance Warrant evidencing a fraction of a Warrant or to
issue fractions of shares or other securities upon the exercise or conversion of
this Warrant.  If any fraction (calculated to the nearest one-hundredth) of a
Warrant or of a share or other securities would, except for the provisions of
this Section 11, be issuable upon the exercise or conversion of any Warrant, the
Company shall, at its option, either purchase such fraction for an amount in
cash equal to the current value of such fraction computed on the basis of the
Fair Market Value thereof, or issue the required fractional Warrant, or share or
other security.  The Warrant Holder expressly waives any right to receive a
replacement or balance Warrant evidencing any fraction of a Warrant or to
receive any fractional share or other securities upon exercise or conversion of
this Warrant, except as expressly provided in this Section 11.  Each adjustment
in the number of shares of Common Stock purchasable hereunder shall be
calculated to the nearest whole share with fractional shares disregarded.

    12.  NO STOCKHOLDER RIGHTS.  This Warrant, as such, shall not entitle the
Warrant Holder to vote, receive dividends or be deemed the holder of Common
Stock or any other securities of the Company which may at any time be issuable
on the exercise of this Warrant for any purpose whatever, nor shall anything
contained herein be construed to confer upon the Warrant Holder any of the
rights of a stockholder of the Company or any right to vote for the election of
directors or upon any matter submitted to stockholders at any meeting thereof,
or to give or withhold consent to any corporate action (whether upon any
recapitalization, issuance of stock,


                                          7
<PAGE>

reclassification of stock, change of par value or change of stock to no par
value, consolidation, merger, conveyance or otherwise), or to receive notice of
meetings or other actions affecting stockholders (except as provided in
Section 9 hereof), or to receive dividend or subscription rights, or otherwise,
until this Warrant shall have been exercised or converted in accordance with the
provisions hereof.

    13.  TRANSFER AND EXCHANGE OF WARRANT.  Subject to Section 11, this Warrant
is exchangeable, upon the surrender hereof by the Warrant Holder at the
principal office of the Company, for new Warrants of like tenor representing in
the aggregate the rights to subscribe for and purchase the number of Shares
which may be subscribed for and purchased hereunder, each of such new Warrants
to represent the right to subscribe for and purchase such number of Shares as
shall be designated by the Warrant Holder at the time of such surrender.
Subject, if applicable, to the restrictions provided in Section 5.10 of the
Purchase Agreement, this Warrant and all rights hereunder may be transferred, in
whole or in part, on the books of the Company maintained for such purpose at the
principal office of the Company, by the Warrant Holder hereof in person, or by
duly authorized attorney, upon surrender of this Warrant properly endorsed and
upon payment of any necessary transfer tax or other governmental charge imposed
upon such transfer.  Upon any partial transfer, the Company will issue and
deliver to the Warrant Holder a new Warrant with respect to the Warrant balance
not so transferred.  Each taker and holder of this Warrant or any Warrant issued
upon transfer hereof, by taking or holding the same, consents and agrees to be
bound by the terms, conditions, representations and warranties hereof (and as a
condition to any transfer of this Warrant the transferee shall upon request by
the Company execute an agreement confirming the same), and, when this Warrant
shall have been so endorsed and presented, the person in possession of this
Warrant may be treated by the Company, and all other persons dealing with this
Warrant, as the absolute owner hereof for any purpose and as the person entitled
to exercise the rights represented hereby, any notice to the contrary
notwithstanding; PROVIDED, HOWEVER that until a transfer of this Warrant is duly
registered on the books of the Company, the Company may treat the Warrant Holder
hereof as the owner of this Warrant for all purposes.

    14.  LOST, STOLEN, MUTILATED OR DESTROYED WARRANT.  If this Warrant is
lost, stolen, mutilated or destroyed, the Company may, on such customary and
reasonable terms as to indemnity or otherwise as it may in its discretion impose
(which shall, in the case of a mutilated Warrant, include the surrender
thereof), issue a new Warrant of like denomination and tenor as the Warrant so
lost, stolen, mutilated or destroyed.

    15.  RESTRICTIONS ON TRANSFER.

         15.1.   CERTIFICATES.  Certificates representing any of the Shares
acquired pursuant to the provisions of this Warrant shall have endorsed thereon
the following legends, as appropriate.

                 (a)    Unless such Shares are received in a transaction
registered under the Securities Act and qualified (if necessary) under
applicable state securities laws:

    "THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, TRANSFERRED,
ASSIGNED OR HYPOTHECATED UNLESS THERE IS AN


                                          8
<PAGE>

EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT COVERING SUCH SECURITIES, THE
SALE IS MADE IN ACCORDANCE WITH RULE 144 UNDER THE ACT, OR THE COMPANY RECEIVES
AN OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES REASONABLY SATISFACTORY
TO THE COMPANY, STATING THAT SUCH SALE, TRANSFER, ASSIGNMENT OR HYPOTHECATION IS
EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SUCH ACT."

                 (b)    If such Shares are to be issued to Tako Ventures, LLC
or its affiliates:

         "UNTIL JUNE 17, 2002, THE SECURITIES EVIDENCED BY THIS CERTIFICATE ARE
    SUBJECT TO RESTRICTIONS ON TRANSFER, INCLUDING RIGHTS OF FIRST REFUSAL SET
    FORTH IN A CONVERTIBLE SECURED NOTE, OPTION AND WARRANT PURCHASE AGREEMENT
    DATED AS OF JUNE 17, 1997 BY AND AMONG SUPERGEN, INC., TAKO VENTURES, LLC
    AND, SOLELY FOR PURPOSES OF SECTIONS 5.3 AND 5.5 THEREOF,  LAWRENCE J.
    ELLISON, A COPY OF WHICH AGREEMENT MAY BE OBTAINED AT NO COST BY WRITTEN
    REQUEST MADE BY THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE SECRETARY
    OF SUPERGEN, INC. AT SUPERGEN, INC.'S PRINCIPAL EXECUTIVE OFFICES."

                 (c)    Any legend required to be placed thereon by any
applicable state securities laws.

         15.2.   COMPLIANCE WITH ACT.  The Warrant Holder, by acceptance
hereof, agrees that this Warrant and the Shares to be issued upon the exercise
or conversion hereof are being acquired solely for its own account and not as a
nominee for any other party and not with a view toward the resale or
distribution thereof and that it will not offer, sell or otherwise dispose of
this Warrant or any Shares to be issued upon the exercise or conversion hereof
except under circumstances which will not result in a violation of the
Securities Act or of applicable state securities laws.

    16.  MISCELLANEOUS.

         16.1.   ENTIRE AGREEMENT.  This Warrant and the related agreements
referenced herein constitute the entire agreement of the parties and supersede
all prior undertakings and agreements with respect to the subject matter hereof.

         16.2.   WAIVERS AND AMENDMENTS.  This Warrant or any provision hereof
may be changed, waived, discharged or terminated only by a statement in writing
signed by the party against which enforcement of the change, waiver, discharge
or termination is sought.

         16.3.   APPLICABLE LAW.  This Warrant shall be governed and controlled
as to validity, enforcement, interpretation, construction, effect and in all
other respects by the internal laws (excluding conflicts of law rules) of the
State of California applicable to contracts made and performed in that


                                          9
<PAGE>

State; provided, however, that if the Company has merged into a Delaware
corporation, then this Warrant shall be governed and controlled as to validity,
enforcement, interpretation, construction, effect and in all other respects  by
the internal laws (excluding conflict of law rules) of the State of Delaware
applicable to contracts made and performed in that State.

         16.4.   NOTICES.  All notices required or permitted to be given
hereunder shall be in writing and shall be deemed given when delivered in person
or sent by confirmed facsimile, or when received if given by Federal Express or
other internationally recognized overnight courier service, or by mail, postage
prepaid, registered or certified airmail, addressed to the applicable party as
follows:

    if to the Warrant Holder, addressed
    to the Warrant Holder:        Tako Ventures, LLC
                                  c/o Howson & Simon
                                  220 Montgomery Street, Suite 1041
                                  San Francisco, CA  94101
                                  Attention:  Philip Simon
                                  Fax: (415) 788-1935

    with a copies to:             Rivin Detwiler Dudnick & Strikker
                                  351 California Street, Fifteenth  Floor
                                  San  Francisco, CA  94104
                                  Attention:  Andrew Dudnick, Esq.
                                  Fax: (415) 982-1401

                                  Gray Cary Ware & Freidenrich, A Professional
                                  Corporation
                                  400 Hamilton Avenue
                                  Palo Alto, CA  94301
                                  Attention:  Rod J. Howard, Esq., Brad J.
                                  Rock, Esq.
                                  Fax:  (415) 327-3699

    if to the Company,
    addressed to the Company:     SuperGen, Inc.
                                  Two Annabel Lane
                                  Suite 220
                                  San Ramon, California  94583
                                  Attention:  Dr. Joseph Rubinfeld
                                  Fax:  510-327-7347

    with a copy to:               Wilson Sonsini Goodrich & Rosati
                                  Professional Corporation
                                  650 Page Mill Road
                                  Palo Alto, California 94304-1050
                                  Attn:  Page Mailliard, Esq.

and/or to such other respective addresses and/or addressees as may be designated
by notice given in accordance with the provisions of this Section 16.4.


                                          10
<PAGE>

         16.5.   HEADINGS.  The headings in this Warrant are for convenience of
reference only and shall not affect the meaning or interpretation of this
Warrant.

                                       SUPERGEN, INC.:



                        By: /s/ Dr. Joseph Rubinfeld
                            -------------------------------------------------
                        Title: Dr. Joseph Rubinfeld, Chief Executive Officer,

                               President and Chief Scientific Officer


                                          11
<PAGE>

                                     EXHIBIT W-1
                           NOTICE OF EXERCISE OR CONVERSION

                                                           Date:________, 19____

SuperGen, Inc.
Two Annabel Lane
Suite 220
San Ramon, California  94583

Attention: _________________________

Dear M__________________:

               The undersigned hereby elects to exercise or convert the 
enclosed Warrant dated           , 1997 issued to it by SuperGen, Inc. (the 
"Company").

     The undersigned elects to:

     /_/  Exercise the Warrant and to purchase thereunder ______ shares of 
          the Common Stock of the Company (the "Shares") at an exercise price 
          of $13.50 per Share (as adjusted pursuant to Section 8 of the 
          Warrant), or an aggregate purchase price of _____________ Dollars 
          ($________) (the "Purchase Price").  Pursuant to the terms of the 
          Warrant, the undersigned has delivered the Purchase Price herewith 
          in full, of which Purchase Price, $__________ is to be paid by 
          tender of ________ shares of the Company's  Common  Stock which are 
          delivered herewith in form suitable for transfer.

     /_/  Convert the value of ________ shares of the Common Stock issuable 
          pursuant to the Warrant at the Exercise Price (as defined in the 
          Warrant) of $13.50 per Share (as adjusted pursuant to Section 8 of 
          the Warrant).

     The undersigned hereby represents and warrants that all of the 
representations and warranties of the undersigned set forth in Section 15.2 
of the Warrant are true and correct as of the date hereof, and that the 
undersigned has executed and delivered the Investment Letter attached as 
EXHIBIT W-2 to the Warrant.

                                           Very truly yours,


                                           Warrant Holder

                                           By:__________________________________

                                           Title:_______________________________

Accepted and Acknowledged:

SuperGen, Inc.

By: ___________________________

Dated: _________________, 19___


                                          12

<PAGE>

                                     EXHIBIT W-2


THIS AGREEMENT MUST BE COMPLETED, SIGNED AND RETURNED TO SUPERGEN, INC. ALONG 
WITH THE SUBSCRIPTION FORM BEFORE THE COMMON STOCK ISSUABLE UPON EXERCISE OF 
THE WARRANT DATED           , 1997 WILL BE ISSUED.

                                  INVESTMENT LETTER

                                  __________, 19___

SuperGen, Inc.
Two Annabel Lane
San Ramon, California  94583

Attention:  _______________________

Dear M___________:

     The undersigned, _________________ ("Purchaser"), intends to acquire up 
to ________ shares of the Common Stock (the "Stock") of SuperGen, Inc. 
("SuperGen") from SuperGen pursuant to the exercise of certain warrants to 
purchase stock held by the Purchaser.  The Stock will be issued to Purchaser 
in a transaction not involving a public offering and pursuant to an exemption 
from registration under the Securities Act of 1933, as amended (the "1933 
Act") and applicable state securities laws.  In connection with such purchase 
and in order to comply with the exemptions from registration relied upon by 
SuperGen, Purchaser represents, warrants and agrees as follows:

     The Purchaser is an accredited investor within the meaning of Rule 501 
under the 1933 Act and has such knowledge and experience in financial and 
business matters that the Purchaser is capable of evaluating the merits and 
risks of the purchase of the Stock and of protecting Purchaser's interests in 
connection therewith.

     Purchaser is acquiring the Stock for its own account, to hold for 
investment, and Purchaser shall not make any sale, transfer or other 
disposition of the Stock in violation of the 1933 Act or the General Rules 
and Regulations promulgated thereunder by the Securities and Exchange 
Commission (the "SEC") or in violation of any applicable state securities law.

     Purchaser has been advised that the Stock has not been registered under 
the 1933 Act or state securities laws on the ground that this transaction is 
exempt from registration, and that reliance by SuperGen on such exemptions is 
predicated in part on Purchaser's representations set forth in this letter.

     Purchaser has been informed that under the 1933 Act, the Stock must be 
held indefinitely unless it is subsequently registered under the 1933 Act or 
unless an exemption from such registration (such as Rule 144) is available 
with respect to any proposed transfer or disposition by Purchaser of the 
Stock.  Purchaser further agrees that SuperGen may refuse to permit Purchaser 
to sell, transfer or dispose of the Common Stock (except as permitted under 
Rule 144) unless there is in effect a

                                          13
<PAGE>

registration statement under the 1933 Act and any applicable state securities 
laws covering such transfer, or unless Purchaser furnishes an opinion of 
counsel reasonably satisfactory to counsel for SuperGen, to the effect that 
such registration is not required.

     Purchaser also understands and agrees that there will be placed on the 
certificate(s) for the Stock, or any substitutions therefor, applicable 
legends stating in substance:

     "THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED 
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, 
TRANSFERRED, ASSIGNED OR HYPOTHECATED UNLESS THERE IS AN EFFECTIVE 
REGISTRATION STATEMENT UNDER SUCH ACT COVERING SUCH SECURITIES, THE SALE IS 
MADE IN ACCORDANCE WITH RULE 144 UNDER THE ACT, OR THE COMPANY RECEIVES AN 
OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES REASONABLY SATISFACTORY 
TO THE COMPANY, STATING THAT SUCH SALE, TRANSFER, ASSIGNMENT OR HYPOTHECATION 
IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SUCH 
ACT."

     If such Shares are to be issued to Tako Ventures, LLC or its affiliates: 
"THE SECURITIES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO RESTRICTIONS ON 
TRANSFER, INCLUDING RIGHTS OF FIRST REFUSAL SET FORTH IN A CONVERTIBLE 
SECURED NOTE, OPTION AND WARRANT PURCHASE AGREEMENT DATED AS OF JUNE 17, 1997 
BY AND AMONG SUPERGEN, INC., TAKO VENTURES, LLC AND, SOLELY FOR PURPOSES OF 
SECTIONS 5.3 AND 5.5 THEREOF LAWRENCE J. ELLISON, A COPY OF WHICH AGREEMENT 
MAY BE OBTAINED AT NO COST BY WRITTEN REQUEST MADE BY THE HOLDER OF RECORD OF 
THIS CERTIFICATE TO THE SECRETARY OF SUPERGEN, INC. AT SUPERGEN, INC.'S 
PRINCIPAL EXECUTIVE OFFICES."

     Purchaser has carefully read this letter and has discussed its 
requirements and other applicable limitations upon Purchaser's resale of the 
Stock with Purchaser's counsel.

                                           Very truly yours,



                                           Purchaser

                                           By: _________________________________

                                           Title: ______________________________


                                          14


<PAGE>

THE SECURITY EVIDENCED BY THIS WARRANT AND THE SECURITIES TO BE PURCHASED 
UNDER THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, 
AS AMENDED, AND MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED UNLESS THERE IS AN 
EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT COVERING SUCH SECURITIES, THE 
SALE, TRANSFER OR ASSIGNMENT IS MADE IN ACCORDANCE WITH RULE 144 UNDER THE 
ACT, OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE HOLDER OF THESE 
SECURITIES REASONABLY SATISFACTORY TO THE COMPANY, STATING THAT SUCH SALE, 
TRANSFER OR ASSIGNMENT IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS 
DELIVERY REQUIREMENTS OF SUCH ACT.

THE SECURITY EVIDENCED BY THIS WARRANT AND THE SECURITIES TO BE PURCHASED 
UNDER THIS WARRANT ARE SUBJECT TO RESTRICTIONS ON TRANSFER, INCLUDING RIGHTS 
OF FIRST REFUSAL SET FORTH IN A CONVERTIBLE SECURED NOTE, OPTION AND WARRANT 
PURCHASE AGREEMENT DATED JUNE 17, 1997, BY AND AMONG SUPERGEN, INC., TAKO 
VENTURES, LLC AND, SOLELY FOR PURPOSES OF SECTIONS 5.3 AND 5.5 THEREOF, 
LAWRENCE J. ELLISON, A COPY OF WHICH AGREEMENT MAY BE OBTAINED AT NO COST BY 
WRITTEN REQUEST MADE BY THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE 
SECRETARY OF SUPERGEN, INC. AT SUPERGEN, INC.'S PRINCIPAL EXECUTIVE OFFICES.

No. 1                                       Right to Purchase 350,000
June 17, 1997                               Shares of Common Stock
Void after June 17, 2007

                                    SUPERGEN, INC.

                        SERIES 2 COMMON STOCK PURCHASE WARRANT
                                     (Redeemable)

    SuperGen, Inc., a California corporation (the "Company"), hereby certifies
that, for good and valuable consideration, Tako Ventures, LLC, a California
limited liability company (the "Warrant Holder"), is entitled, subject to the
terms set forth below, to purchase from the Company at any time during the
period commencing at 10:00 a.m. on June 17, 1997 and ending on the earlier of
(i) the delivery of any Notice of Demand pursuant to that certain Convertible
Secured Note, Option and Warrant Purchase Agreement by and among the Company,
Tako Ventures, LLC, and solely for purposes of Sections 5.3 and 5.5 thereof,
Lawrence J. Ellison dated as of June 17, 1997 (the "Purchase Agreement") and
(ii) 5:00 p.m., Pacific Time, on June 17, 2007, subject to earlier redemption in
accordance with Section 3 below (the "Exercise Period"), up to the number of
fully-paid and non-assessable shares of Common Stock of the Company set forth in
Section 1 below for the price per share set forth in Section 2 below, subject to
adjustment as herein provided.

    1.   NUMBER OF SHARES.  Subject to adjustment as provided in Section 8
below, this Warrant shall be exercisable for Three Hundred Fifty Thousand
($350,000) shares of Common Stock of the  Company, par value $0.001 (the
"Shares").


<PAGE>

    2.   EXERCISE PRICE.  This Warrant shall be exercisable at a price (the
"Exercise Price") equal to Thirteen Dollars and Fifty Cents ($13.50) per Share,
in U.S. dollars, subject to adjustment as provided in Section 8 below.

    3.   REDEMPTION BY THE ISSUER.

         3.1 From and after the Conversion Time (as defined in the Purchase
Agreement) this Warrant may be redeemed at the option of the Company, in whole
or in part on a pro-rata basis with all other Series 2 Warrants then
outstanding, at any time if, at the time notice of such redemption is given by
the Company as provided in Section 3.3, below, the Daily Price (after adjustment
in accordance with Section 8.9) has exceeded $27.00 for the thirty (30)
consecutive trading days immediately preceding the date of such notice, at a
price equal to $0.25 per Warrant (the "Redemption Price").  For the purpose of
the foregoing sentence, the term "Daily Price" shall mean, for any relevant day,
the closing bid price on that day as reported by the principal exchange or
quotation system on which prices for the Common Stock are reported.  On the
Redemption Date (as defined below), the Warrant Holder shall be entitled to
payment of the Redemption Price upon surrender of the redeemed portion of this
Warrant to the Company at its principal office.

         3.2 A written notice of any redemption of this Warrant, which shall
set forth the date for the redemption, which date must be not less than thirty
(30) days and not more than sixty (60) days following the date of such notice
(the "Redemption Date"), shall be delivered by registered or certified mail,
return receipt requested, to the Warrant Holder at its address appearing on the
books or transfer records of the Company (or such other address designated in
writing by the Warrant Holder to the Company not less than forty (40) days prior
to the Redemption Date).

         3.3 This Warrant remains exercisable and convertible in full, as
otherwise provided for herein, through and until the close of business on the
Redemption Date.  From and after the close of business on the Redemption Date,
all rights of the Warrant Holder (except the right to receive the Redemption
Price) shall terminate.

    4.   EXERCISE OR CONVERSION OF WARRANT.

         4.1 EXERCISE.  During the Exercise Period, this Warrant may be
exercised in whole or in part by the Warrant Holder by executing and delivering
to the Company at its principal office the written notice of exercise in the
form attached hereto as EXHIBIT W-1, specifying the portion of the Warrant to be
exercised and accompanied by this Warrant, and paying to the Company the amount
obtained by multiplying the number of Shares designated in the notice of
exercise by the Exercise Price, as then in effect, in cash (in immediately
available funds) or, where permitted by law, by cancellation of indebtedness of
the Company to the Warrant Holder, or by surrender of shares of the Company's
Common Stock that are clear of all liens, claims, encumbrances or security
interests.  Cash used in payment of some or all of the purchase price of any
exercise hereunder, if in an amount in excess of One Hundred Thousand Dollars
($100,000), shall be by wire transfer of immediately available funds payable to
the order of the Company.

         4.2 CONVERSION.  In lieu of exercising this Warrant or any portion
hereof, the Warrant Holder shall have the right to convert this Warrant or any
portion hereof during the Exercise

<PAGE>

Period into shares of Common Stock by executing and delivering to the Company at
its principal office the written notice of conversion in the form attached
hereto as EXHIBIT W-1, specifying the portion of the Warrant to be converted,
and accompanied by this Warrant.  The number of Shares to be issued upon such
conversion shall be that number of Shares equal to the quotient obtained by
dividing (x) the value of the converted portion of the Warrant at the time the
conversion right is exercised (determined by subtracting the aggregate Exercise
Price for the Shares represented by the portion of the Warrant to be converted
from the Fair Market Value of such Shares at the time of conversion) by (y) the
Fair Market Value of one Share at such time.  As used herein, "FAIR MARKET
VALUE" means, as of any date, the value of a share of the Company's Common Stock
determined as follows:

         (a)  if such Common Stock is then quoted on The Nasdaq National
Market, the simple average of the closing sale prices as reported on The Nasdaq
National Market for the ten (10) consecutive trading days prior to such date;


         (b)  if such Common Stock is publicly traded and is then listed on a
national securities exchange, the simple average of the closing sale prices on
the principal national securities exchange on which the Common Stock is listed
or admitted to trading for the ten (10) consecutive trading days prior to such
date;

         (c)  if such Common Stock is publicly traded but is not quoted on The
Nasdaq National Market nor listed or admitted to trading on a national
securities exchange, the simple average of the closing bid prices for the ten
(10) consecutive trading days prior to such date, as reported by The Wall Street
Journal or other widely available reporting source, for the over-the-counter
market; or

         (d)  if none of the foregoing is applicable, by the Board of Directors
of the Company in good faith.
Any portion of this Warrant that is converted shall be immediately canceled.

         4.3 INVESTMENT LETTER.  Upon exercise or conversion of the Warrant in
accordance with Sections 4.1 or 4.2 hereof, the Warrant Holder shall either
(i) execute and deliver to the Company an investment letter in the form attached
hereto as EXHIBIT W-2 or (ii) deliver to the Company an opinion of counsel for
the Warrant Holder reasonably satisfactory to the Company, stating that such
exercise or conversion is exempt from the registration and prospectus delivery
requirements of such the Securities Act of 1933, as amended (the "Securities
Act").


         4.4 LIMITATION ON EXERCISE OR CONVERSION.  Notwithstanding
Sections 4.1 and 4.2 and any other provisions of this Warrant, the Warrant
Holder's rights to obtain shares of Common Stock (or other voting securities
that the Warrant Holder may otherwise become entitled to receive in accordance
with Section 8 below) upon exercise or conversion of this Warrant shall be
subject to the expiration or early termination of any applicable waiting periods
relating to the acquisition of such securities by the Warrant Holder under the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and, if
applicable, shall be subject to and limited by the provisions set forth in
Section 5.5 of the Purchase Agreement.

<PAGE>

    5.   DELIVERY OF STOCK CERTIFICATES, ETC.  As soon as practicable after the
exercise or conversion of this Warrant (in full or in part) in accordance with
Section 4 above, the Company at its expense will cause to be issued in the name
of and delivered to the Warrant Holder (i) a certificate or certificates for the
number of fully paid and nonassessable Shares to which the Warrant Holder shall
be entitled upon such exercise or conversion and (ii) a new Warrant of like
tenor to purchase all of the Shares that may be purchased pursuant to the
portion, if any, of the Warrant not exercised or converted by the Warrant
Holder.  The Warrant Holder shall for all purposes be deemed to have become the
holder of record of such Shares at the close of business on the date on which
this Warrant was surrendered together with a notice of exercise or conversion
and, in the case of exercise, payment of the Exercise Price was made,
irrespective of the date of delivery of such certificate or certificates, except
that, if the date of such surrender, notice and payment is a date when the stock
transfer books of the Company are closed, the Warrant Holder shall be deemed to
have become the holder of record of such Shares at the close of business on the
next succeeding date on which the stock transfer books are open.

    6.   COVENANTS AS TO COMMON STOCK.  The Company covenants and agrees that
all the Shares will, upon issuance, be validly issued and outstanding, fully
paid and nonassessable, with no personal liability attaching to the ownership
thereof, and free from all taxes, liens and charges with respect to the issuance
thereof.  The Company further covenants and agrees that the Company will at all
times have authorized and reserved, and free from preemptive rights, a
sufficient number of shares of Common Stock to provide for the exercise of the
rights represented by this Warrant.

    7.   REGISTRATION RIGHTS.  This Warrant and the Shares issued or issuable
upon the exercise or conversion of this Warrant are subject to registration in
accordance with the registration rights in favor of the Warrant Holder as
provided for in Article VI of the Purchase Agreement.


    8.   ADJUSTMENTS.

         8.1 In the event that the Company shall (i) pay a dividend in, or make
a distribution of, shares of capital stock or other securities (including,
without limitation, any rights or options to subscribe to or purchase any
additional shares of any class of its capital stock, any evidence of its
indebtedness or assets, or any other rights or options) on its outstanding
Common Stock, (ii) subdivide its outstanding shares of Common Stock into a
greater number of such shares or (iii) combine its outstanding shares of Common
Stock into a smaller number of such shares, the total number of Shares
purchasable upon the exercise of this Warrant shall be adjusted so that upon the
subsequent exercise of this Warrant, the Warrant Holder shall be entitled to
receive at the same aggregate Exercise Price the number of shares of capital
stock and other securities (of one or more classes) which such holder would have
owned or would have been entitled to receive immediately following the happening
of any of the events described above had this Warrant been exercised in full
immediately prior to the record date with respect to such event.  Any adjustment
made pursuant to this Section shall, in the case of a dividend or distribution
of stock or other securities, become effective as of the record date therefor
and, in the case of a subdivision or combination, be made as of the effective
date thereof.  If, as a result of an adjustment made pursuant to this Section,
the Warrant Holder shall become entitled to receive shares or other units of two
or more classes of capital stock or other securities of the Company upon a
subsequent exercise hereof, the Board of Directors of the Company (whose
reasonable determination shall be conclusive and, upon request by the Warrant
Holder, shall be evidenced by a certified Board

<PAGE>

resolution delivered to the Warrant Holder) shall determine the allocation of
the adjusted Exercise Price between or among shares of such classes of capital
stock.  The above provisions of this Section 8.1 shall apply similarly to
successive stock dividends, subdivisions and combinations.

         8.2 In the event of a capital reorganization or a reclassification of
the Common Stock (except as provided in Section 8.1 above or Section 8.4 below),
any Warrant Holder, upon exercise of this Warrant, shall be entitled to receive,
in substitution for the Common Stock to which it would have become entitled upon
exercise immediately prior to such reorganization or reclassification, the
shares (of any class or classes) or other securities or property of the Company
(or cash) that it would have been entitled to receive at the same aggregate
Exercise Price upon such reorganization or reclassification if this Warrant had
been exercised immediately prior to the record date with respect to such event;
and in any such case, appropriate provision (as determined by the Board of
Directors of the Company, whose reasonable determination shall be conclusive
and, upon request by the Warrant Holder, shall be evidenced by a certified Board
resolution delivered to the Warrant Holder) shall be made for the application of
this Section 8.2 with respect to the rights and interests thereafter of the
Warrant Holder (including but not limited to the allocation of the Exercise
Price between or among shares of classes of capital stock or other securities),
to the end that this Section 8.2 (including the adjustments of the number of
shares of Common Stock or other securities purchasable and the Exercise Price
thereof) shall thereafter be reflected, as nearly as reasonably practicable, in
all subsequent exercises of this Warrant for any shares or securities or other
property (or cash) thereafter deliverable upon the exercise hereof.  The above
provisions of this Section 8.2 shall apply similarly to successive
reorganizations or recapitalizations.


         8.3 Whenever the number of shares of Common Stock or other securities
purchasable upon exercise of this Warrant is adjusted as provided in this
Section 8, the Company will promptly deliver to the Warrant Holder a certificate
signed by a Chairman or co-Chairman of the Board or the President or a Vice
President of the Company and by the Treasurer or an Assistant Treasurer or the
Secretary or an Assistant Secretary of the Company setting forth the number and
kind of securities or other property purchasable upon exercise of this Warrant,
as so adjusted, stating that such adjustments in the number or kind of shares or
other securities or property conform to the requirements of this Section 8, and
setting forth a brief statement of the facts accounting for such adjustments;
PROVIDED, HOWEVER, that failure to deliver any notice required under this
Section 8.3, or any defect therein, shall not affect the legality or validity of
any such adjustments under this Section 8; and PROVIDED, FURTHER, that, where
appropriate, such notice may be given in advance and included as part of the
notice required to be given pursuant to Section 9 hereof.

<PAGE>

         8.4 In the event of any consolidation or share exchange reorganization
of the Company with, or merger of the Company into, another corporation (other
than a consolidation, share exchange reorganization or merger which does not
result in any reclassification or change of the outstanding Common Stock), or in
case of any sale or conveyance to another corporation of the property of the
Company as an entirety or substantially as an entirety, the entity formed by
such consolidation, share exchange reorganization or merger or the person which
shall have acquired such property, as the case may be, shall execute and deliver
to the Warrant Holder a new warrant providing that the Warrant Holder shall have
the right thereafter (until the expiration of this Warrant) to receive, upon
exercise of such warrant, solely the kind and amount of shares of stock and
other securities and property (or cash) receivable upon such consolidation,
share exchange reorganization, merger, sale or transfer by a holder of the
number of shares of Common Stock of the Company for which this Warrant might
have been exercised immediately prior to such consolidation, share exchange
reorganization, merger, sale or transfer.  Such new warrant shall provide for
adjustments which shall be as nearly equivalent as may be practicable to the
adjustments provided in this Section 8.4.  The above provision of this
Section 8.4 shall similarly apply to successive consolidations, share exchange
reorganizations, mergers, sales or transfers.

         8.5 Irrespective of any adjustments in the number or kind of shares or
other securities or property issuable upon exercise of this Warrant, this
Warrant and any replacement or balance Warrants thereafter issued may continue
to express the same price and number and kind of shares as are stated in the
original Warrant.

         8.6 The Company may retain a firm of independent public accountants of
recognized standing, which may be the firm regularly retained by the Company,
selected by the Board of Directors of the Company or the Executive Committee of
said Board, to make any computation required under this Section 8, and a
certificate signed by such firm shall, in the absence of fraud or gross
negligence, be conclusive evidence of the correctness of any computation made
under this Section 8.

         8.7 For the purpose of this Section 8, the term "Common Stock" shall
mean (i) the class of stock designated as Common Stock in the Restated Articles
of Incorporation of the Company, as amended, at the date of this Warrant, or
(ii) any other class of stock resulting from successive changes or
reclassifications of such Common Stock consisting solely of changes in par
value, or from par value to no par value, or from no par value to par value.  In
the event that at any time as a result of an adjustment made pursuant to this
Section 8, the Warrant Holder shall become entitled to receive any shares of
capital stock of the Company other than shares of Common Stock, thereafter the
number of such other shares so receivable upon exercise of this Warrant shall be
subject to adjustment from time to time in a manner and on terms as nearly
equivalent as practicable to the provisions with respect to the Common Stock
contained in this Section 8, and all other provisions of this Warrant, with
respect to the Common Stock, shall apply on like terms to any such other shares.

         8.8 The Company may, from time to time and to the extent permitted by
law, reduce the exercise price of this Warrant by any amount for a period of not
less than twenty (20) days.  If the Company so reduces the exercise price of
this Warrant, it will give the Warrant Holder not less than fifteen (15) days'
notice of such decrease, and shall take such other steps as may be

<PAGE>

required under applicable law in connection with any offers or sales of
securities at the reduced price.

         8.9 Whenever the number of Shares purchasable upon the exercise of
this Warrant is adjusted as provided in Section 8, the Exercise Price for each
Share payable upon exercise shall be adjusted by multiplying such Exercise Price
immediately prior to such adjustment by a fraction, the numerator of which shall
be the number of Shares purchasable upon the exercise of the Warrant immediately
prior to such adjustment, and the denominator of which shall be the number of
Shares so purchasable immediately thereafter.

    9.   NOTICE OF CERTAIN CORPORATE ACTIONS.  In case the Company after the
date hereof shall propose (i) to offer to the holders of Common Stock,
generally, rights to subscribe to or purchase any additional shares of any class
of its capital stock, any evidences of its indebtedness or assets, or any other
rights or options or (ii) to effect any reclassification of Common Stock (other
than a reclassification involving merely the subdivision or combination of
outstanding shares of Common Stock) or any capital reorganization, or any
consolidation or merger to which the Company is a party and for which approval
of any stockholders of the Company is required, or any sale, transfer or other
disposition of its property and assets substantially as an entirety, or the
liquidation, voluntary or involuntary dissolution or winding-up of the Company,
then, in each such case, the Company shall deliver to the Warrant Holder notice
of such proposed action, which notice shall specify the date on which the books
of the Company shall close or a record be taken for such offer of rights or
options, or the date on which such reclassification, reorganization,
consolidation, merger, sale, transfer, other disposition, liquidation, voluntary
or involuntary dissolution or winding-up shall take place or commence, as the
case may be, and which shall also specify any record date for determination of
holders of Common Stock entitled to vote thereon or participate therein and
shall set forth such facts with respect thereto as shall be reasonably necessary
to indicate any adjustments in the Exercise Price and the number or kind of
shares or other securities purchasable upon exercise of the Warrant which will
be required as a result of such action.  Such notice shall be sent, in the case
of any action covered by clause (i) above, at least ten (10) days prior to the
record date for determining holders of the Common Stock for purposes of such
action or, if a record is not to be taken, the date as of which the holders of
shares of Common Stock of record are to be entitled to such offering; and, in
the case of any action covered by clause (ii) above, at least twenty (20) days
prior to the earlier of the date on which such reclassification, reorganization,
consolidation, merger, sale, transfer, other disposition, liquidation, voluntary
or involuntary dissolution or winding-up is expected to become effective and the
date on which it is expected that holders of shares of Common Stock of record on
such date shall be entitled to exchange their shares for securities or other
property deliverable upon such reclassification, reorganization, consolidation,
merger, sale, transfer, other disposition, liquidation, voluntary or involuntary
dissolution or winding-up.

    10.  TAXES.  The Company shall pay all documentary, stamp or other
transactional taxes attributable to the issuance or delivery of shares of
capital stock or other securities of the Company upon the exercise hereof.

<PAGE>

    11.  NO FRACTIONAL INTERESTS.  The Company shall not be required to issue
any replacement or balance Warrant evidencing a fraction of a Warrant or to
issue fractions of shares or other securities upon the exercise or conversion of
this Warrant.  If any fraction (calculated to the nearest one-hundredth) of a
Warrant or of a share or other securities would, except for the provisions of
this Section 11, be issuable upon the exercise or conversion of any Warrant, the
Company shall, at its option, either purchase such fraction for an amount in
cash equal to the current value of such fraction computed on the basis of the
Fair Market Value thereof, or issue the required fractional Warrant, or share or
other security.  The Warrant Holder expressly waives any right to receive a
replacement or balance Warrant evidencing any fraction of a Warrant or to
receive any fractional share or other securities upon exercise or conversion of
this Warrant, except as expressly provided in this Section 11.  Each adjustment
in the number of shares of Common Stock purchasable hereunder shall be
calculated to the nearest whole share with fractional shares disregarded.

    12.  NO STOCKHOLDER RIGHTS.  This Warrant, as such, shall not entitle the
Warrant Holder to vote, receive dividends or be deemed the holder of Common
Stock or any other securities of the Company which may at any time be issuable
on the exercise of this Warrant for any purpose whatever, nor shall anything
contained herein be construed to confer upon the Warrant Holder any of the
rights of a stockholder of the Company or any right to vote for the election of
directors or upon any matter submitted to stockholders at any meeting thereof,
or to give or withhold consent to any corporate action (whether upon any
recapitalization, issuance of stock, reclassification of stock, change of par
value or change of stock to no par value, consolidation, merger, conveyance or
otherwise), or to receive notice of meetings or other actions affecting
stockholders (except as provided in Section 9 hereof), or to receive dividend or
subscription rights, or otherwise, until this Warrant shall have been exercised
or converted in accordance with the provisions hereof.

    13.  TRANSFER AND EXCHANGE OF WARRANT.  Subject to Section 11, this Warrant
is exchangeable, upon the surrender hereof by the Warrant Holder at the
principal office of the Company, for new Warrants of like tenor representing in
the aggregate the rights to subscribe for and purchase the number of Shares
which may be subscribed for and purchased hereunder, each of such new Warrants
to represent the right to subscribe for and purchase such number of Shares as
shall be designated by the Warrant Holder at the time of such surrender.
Subject, if applicable, to the restrictions provided in Section 5.10 of the
Purchase Agreement, this Warrant and all rights hereunder may be transferred, in
whole or in part, on the books of the Company maintained for such purpose at the
principal office of the Company, by the Warrant Holder hereof in person, or by
duly authorized attorney, upon surrender of this Warrant properly endorsed and
upon payment of any necessary transfer tax or other governmental charge imposed
upon such transfer.  Upon any partial transfer, the Company will issue and
deliver to the Warrant Holder a new Warrant with respect to the Warrant balance
not so transferred.  Each taker and holder of this Warrant or any Warrant issued
upon transfer hereof, by taking or holding the same, consents and agrees to be
bound by the terms, conditions, representations and warranties hereof (and as a
condition to any transfer of this Warrant the transferee shall upon request by
the Company execute an agreement confirming the same), and, when this Warrant
shall have been so endorsed and presented, the person in possession of this
Warrant may be treated by the Company, and all other persons dealing with this
Warrant, as the absolute owner hereof for any purpose and as the person entitled
to exercise the rights represented hereby, any notice to the contrary

<PAGE>

notwithstanding; PROVIDED, HOWEVER that until a transfer of this Warrant is duly
registered on the books of the Company, the Company may treat the Warrant Holder
hereof as the owner of this Warrant for all purposes.

    14.  LOST, STOLEN, MUTILATED OR DESTROYED WARRANT.  If this Warrant is
lost, stolen, mutilated or destroyed, the Company may, on such customary and
reasonable terms as to indemnity or otherwise as it may in its discretion impose
(which shall, in the case of a mutilated Warrant, include the surrender
thereof), issue a new Warrant of like denomination and tenor as the Warrant so
lost, stolen, mutilated or destroyed.

    15.  RESTRICTIONS ON TRANSFER,

         15.1 CERTIFICATES.  Certificates representing any of the Shares
acquired pursuant to the provisions of this Warrant shall have endorsed thereon
the following legends, as appropriate.

              (a)  Unless such Shares are received in a transaction registered
under the Securities Act and qualified (if necessary) under applicable state
securities laws:

    "THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, TRANSFERRED,
ASSIGNED OR HYPOTHECATED UNLESS THERE IS AN EFFECTIVE REGISTRATION STATEMENT
UNDER SUCH ACT COVERING SUCH SECURITIES, THE SALE IS MADE IN ACCORDANCE WITH
RULE 144 UNDER THE ACT, OR THE COMPANY RECEIVES AN OPINION OF COUNSEL FOR THE
HOLDER OF THESE SECURITIES REASONABLY SATISFACTORY TO THE COMPANY, STATING THAT
SUCH SALE, TRANSFER, ASSIGNMENT OR HYPOTHECATION IS EXEMPT FROM THE REGISTRATION
AND PROSPECTUS DELIVERY REQUIREMENTS OF SUCH ACT."

              (b)  If such Shares are to be issued to Tako Ventures, LLC or its
affiliates:

    "UNTIL JUNE 17, 2002, THE SECURITIES EVIDENCED BY THIS CERTIFICATE ARE
SUBJECT TO RESTRICTIONS ON TRANSFER, INCLUDING RIGHTS OF FIRST REFUSAL SET FORTH
IN A CONVERTIBLE SECURED NOTE, OPTION AND WARRANT PURCHASE AGREEMENT DATED AS OF
JUNE 17, 1997 BY AND AMONG SUPERGEN, INC., TAKO VENTURES, LLC AND, SOLELY FOR
PURPOSES OF SECTIONS 5.3 AND 5.5 THEREOF, LAWRENCE J. ELLISON, A COPY OF WHICH
AGREEMENT MAY BE OBTAINED AT NO COST BY WRITTEN REQUEST MADE BY THE HOLDER OF
RECORD OF THIS CERTIFICATE TO THE SECRETARY OF SUPERGEN, INC. AT SUPERGEN,
INC.'S PRINCIPAL EXECUTIVE OFFICES."

              (c)  Any legend required to be placed thereon by any applicable
state securities laws.

         15.2 COMPLIANCE WITH ACT.  The Warrant Holder, by acceptance hereof,
agrees that this Warrant and the Shares to be issued upon the exercise or
conversion hereof are being acquired solely for its own account and not as a
nominee for any other party and not with a view toward the resale or

<PAGE>

distribution thereof and that it will not offer, sell or otherwise dispose of
this Warrant or any Shares to be issued upon the exercise or conversion hereof
except under circumstances which will not result in a violation of the
Securities Act or of applicable state securities laws.

    16.  MISCELLANEOUS.

         16.1 ENTIRE AGREEMENT.  This Warrant and the related agreements
referenced herein constitute the entire agreement of the parties and supersede
all prior undertakings and agreements with respect to the subject matter hereof.

         16.2 WAIVERS AND AMENDMENTS.  This Warrant or any provision hereof may
be changed, waived, discharged or terminated only by a statement in writing
signed by the party against which enforcement of the change, waiver, discharge
or termination is sought.

         16.3 APPLICABLE LAW.  This Warrant shall be governed and controlled as
to validity, enforcement, interpretation, construction, effect and in all other
respects by the internal laws (excluding conflicts of law rules) of the State of
California applicable to contracts made and performed in that State; provided,
however, that if the Company has merged into a Delaware corporation, then this
Warrant shall be governed and controlled as to validity, enforcement,
interpretation, construction, effect and in all other respects  by the internal
laws (excluding conflict of law rules) of the State of Delaware applicable to
contracts made and performed in that State.

         16.4 NOTICES.  All notices required or permitted to be given hereunder
shall be in writing and shall be deemed given when delivered in person or sent
by confirmed facsimile, or when received if given by Federal Express or other
internationally recognized overnight courier service, or by mail, postage
prepaid, registered or certified airmail, addressed to the applicable party as
follows:

    if to the Warrant Holder, addressed
    to the Warrant Holder:             Tako Ventures, LLC
                                       c/o Howson & Simon
                                       220 Montgomery Street, Suite 1041
                                       San Francisco, CA  94101
                                       Attention:  Philip Simon
                                       Fax: (415) 788-1935

    with copies to:                    Rivin Detwiler Dudnick & Strikker
                                       351 California Street, Fifteenth  Floor
                                       San  Francisco, CA  94104
                                       Attention:  Andrew Dudnick, Esq.
                                       Fax: (415) 982-1401

                                       Gray Cary Ware & Freidenrich, A
                                       Professional Corporation
                                       400 Hamilton Avenue
                                       Palo Alto, CA  94301
                                       Attention:  Rod J. Howard, Esq., Brad J.
                                       Rock, Esq.
                                       Fax:  (415) 327-3699

<PAGE>

    if to the Company,
    addressed to the Company:          SuperGen, Inc.
                                       Two Annabel Lane
                                       Suite 220
                                       San Ramon, California  94583
                                       Attention:  Dr. Joseph Rubinfeld
                                       Fax:  510-327-7347

    with a copy to:                    Wilson Sonsini Goodrich & Rosati
                                       Professional Corporation
                                       650 Page Mill Road
                                       Palo Alto, California 94304-1050
                                       Attn:  Page Mailliard, Esq.

and/or to such other respective addresses and/or addressees as may be designated
by notice given in accordance with the provisions of this Section 16.4.

         16.5 HEADINGS.  The headings in this Warrant are for convenience of
reference only and shall not affect the meaning or interpretation of this
Warrant.



                        SUPERGEN, INC.:



                        By:  /s/ Dr. Joseph Rubinfeld
                           ---------------------------------------------------

                        Title:   Dr. Joseph Rubinfeld, Chief Executive Officer,
                               -----------------------------------------------
                                 President and Chief Scientific Officer














                                      11
<PAGE>

                                     EXHIBIT W-1
                           NOTICE OF EXERCISE OR CONVERSION


                                                         Date:        , 19
                                                              --------    -----

SuperGen, Inc.
Two Annabel Lane
Suite 220
San Ramon, California  94583

Attention:
          --------------------

Dear M                :
      ----------------
     The undersigned hereby elects to exercise or convert the enclosed Warrant
dated      , 1997 issued to it by SuperGen, Inc. (the "Company").

     The undersigned elects to:

     /_/     Exercise the Warrant and to purchase thereunder ______________ 
             shares of the Common Stock of the Company (the "Shares") at an 
             exercise price of $13.50 per Share (as adjusted pursuant to 
             Section 8 of the Warrant), or an aggregate purchase price of 
             _______________________ Dollars ($____________) (the "Purchase 
             Price").  Pursuant to the terms of the Warrant, the undersigned 
             has delivered the Purchase Price herewith in full, of which 
             Purchase Price, $________________is to be paid by tender of 
             ______________ shares of the Company's  Common  Stock which are 
             delivered herewith in form suitable for transfer.

     /_/     Convert the value of __________________ shares of the Common 
             Stock issuable pursuant to the Warrant at the Exercise Price (as
             defined in the Warrant) of $13.50 per Share (as adjusted pursuant
             to Section 8 of the Warrant).

     The undersigned hereby represents and warrants that all of the 
representations and warranties of the undersigned set forth in Section 15.2 
of the Warrant are true and correct as of the date hereof, and that the 
undersigned has executed and delivered the Investment Letter attached as 
EXHIBIT W-2 to the Warrant.

                                       Very truly yours,

                                       Warrant Holder

                                       By:
                                           -----------------------------------

                                       Title:
                                             ---------------------------------

Accepted and Acknowledged:

SuperGen, Inc.

By:
    -------------------------
Dated:                , 19
      ----------------    -----

<PAGE>

                                     EXHIBIT W-2


THIS AGREEMENT MUST BE COMPLETED, SIGNED AND RETURNED TO SUPERGEN, INC. ALONG 
WITH THE SUBSCRIPTION FORM BEFORE THE COMMON STOCK ISSUABLE UPON EXERCISE OF 
THE WARRANT DATED      , 1997 WILL BE ISSUED.

                                  INVESTMENT LETTER

                                   _________, 19___

SuperGen, Inc.
Two Annabel Lane
San Ramon, California  94583

Attention:  
          -----------------------

Dear M                :
      ----------------
     The undersigned, ________________ ("Purchaser"), intends to acquire up 
to __________________ shares of the Common Stock (the "Stock") of SuperGen, 
Inc. ("SuperGen") from SuperGen pursuant to the exercise of certain warrants 
to purchase stock held by the Purchaser.  The Stock will be issued to 
Purchaser in a transaction not involving a public offering and pursuant to an 
exemption from registration under the Securities Act of 1933, as amended (the 
"1933 Act") and applicable state securities laws.  In connection with such 
purchase and in order to comply with the exemptions from registration relied 
upon by SuperGen, Purchaser represents, warrants and agrees as follows:

     The Purchaser is an accredited investor within the meaning of Rule 501 
under the 1933 Act and has such knowledge and experience in financial and 
business matters that the Purchaser is capable of evaluating the merits and 
risks of the purchase of the Stock and of protecting Purchaser's interests in 
connection therewith.

     Purchaser is acquiring the Stock for its own account, to hold for 
investment, and Purchaser shall not make any sale, transfer or other 
disposition of the Stock in violation of the 1933 Act or the General Rules 
and Regulations promulgated thereunder by the Securities and Exchange 
Commission (the "SEC") or in violation of any applicable state securities law.

     Purchaser has been advised that the Stock has not been registered under 
the 1933 Act or state securities laws on the ground that this transaction is 
exempt from registration, and that reliance by SuperGen on such exemptions is 
predicated in part on Purchaser's representations set forth in this letter.

     Purchaser has been informed that under the 1933 Act, the Stock must be 
held indefinitely unless it is subsequently registered under the 1933 Act or 
unless an exemption from such registration (such as Rule 144) is available 
with respect to any proposed transfer or disposition by Purchaser of the 
Stock.  Purchaser further agrees that SuperGen may refuse to permit Purchaser 
to sell, transfer or

<PAGE>

dispose of the Common Stock (except as permitted under Rule 144) unless there 
is in effect a registration statement under the 1933 Act and any applicable 
state securities laws covering such transfer, or unless Purchaser furnishes 
an opinion of counsel reasonably satisfactory to counsel for SuperGen, to the 
effect that such registration is not required.

     Purchaser also understands and agrees that there will be placed on the 
certificate(s) for the Stock, or any substitutions therefor, applicable 
legends stating in substance:

     "THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED 
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, 
TRANSFERRED, ASSIGNED OR HYPOTHECATED UNLESS THERE IS AN EFFECTIVE 
REGISTRATION STATEMENT UNDER SUCH ACT COVERING SUCH SECURITIES, THE SALE IS 
MADE IN ACCORDANCE WITH RULE 144 UNDER THE ACT, OR THE COMPANY RECEIVES AN 
OPINION OF COUNSEL FOR THE HOLDER OF THESE SECURITIES REASONABLY SATISFACTORY 
TO THE COMPANY, STATING THAT SUCH SALE, TRANSFER, ASSIGNMENT OR HYPOTHECATION 
IS EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SUCH 
ACT."

     If such Shares are to be issued to Tako Ventures, LLC or its affiliates: 
"THE SECURITIES EVIDENCED BY THIS CERTIFICATE ARE SUBJECT TO RESTRICTIONS ON 
TRANSFER, INCLUDING RIGHTS OF FIRST REFUSAL SET FORTH IN A CONVERTIBLE 
SECURED NOTE, OPTION AND WARRANT PURCHASE AGREEMENT DATED AS OF JUNE 17, 1997 
BY AND AMONG SUPERGEN, INC., TAKO VENTURES, LLC AND, SOLELY FOR PURPOSES OF 
SECTIONS 5.3 AND 5.5 THEREOF, LAWRENCE J. ELLISON, A COPY OF WHICH AGREEMENT 
MAY BE OBTAINED AT NO COST BY WRITTEN REQUEST MADE BY THE HOLDER OF RECORD OF 
THIS CERTIFICATE TO THE SECRETARY OF SUPERGEN, INC. AT SUPERGEN, INC.'S 
PRINCIPAL EXECUTIVE OFFICES."

     Purchaser has carefully read this letter and has discussed its 
requirements and other applicable limitations upon Purchaser's resale of the 
Stock with Purchaser's counsel.

                                 Very truly yours,



                                 Purchaser

                                 By:
                                     ----------------------------------

                                 Title:
                                        -------------------------------



<PAGE>

                            PLEDGE AND SECURITY AGREEMENT

    THIS PLEDGE AND SECURITY AGREEMENT (the "SECURITY AGREEMENT") is made as of
June 17, 1997, by and between SuperGen, Inc., a California corporation (the
"COMPANY"), and Tako Ventures, LLC, a California limited liability company
("LENDER").

                                       RECITALS

    The Company and Lender have entered into a Convertible Secured Note, Option
and Warrant Purchase Agreement of even date herewith (the "PURCHASE AGREEMENT"),
pursuant to which, among other things, (i) Lender has agreed to extend a
$15,300,000 loan to the Company pursuant to the Convertible Secured Note, and
(ii) the Company has agreed to secure the performance of the Company's
obligations under the Note, the Company has agreed to grant Lender a first
priority security interest in the Collateral, as defined herein.

    NOW, THEREFORE, the Company and Lender agree as follows:

                                      AGREEMENT

     1.  CERTAIN DEFINITIONS.  Capitalized terms used herein without definition
shall have the meanings ascribed to such terms in the Purchase Agreement.

     2.  PLEDGE OF COLLATERAL.

         (a)  Subject to the provisions of Section 7 of this Security
Agreement, the Company hereby pledges, assigns and delivers to Lender and grants
to Lender a first lien and security interest in the funds advanced by Purchaser
to the Company as evidenced by the Note, together with all short-term debt
instruments and obligations acquired therewith (including, without limitation,
the certificates of deposit and time deposit accounts and instruments described
in ANNEX A hereto), all substitutions therefor, all interest and other amounts
in the nature of interest paid thereon, and all other cash and noncash proceeds
of the foregoing (all hereinafter called the "COLLATERAL"), to the full extent
of any interest of the Company therein, as security for the timely performance
of all obligations of the Company pursuant to the Note (the "OBLIGATIONS").

         (b)  Any certificate or certificates for the securities included in
the Collateral, accompanied by an instrument of assignment duly executed in
blank by the Company, have been, or will be immediately upon the subsequent
receipt thereof by the Company, delivered by the Company to Lender.

     3.  REPRESENTATIONS AND WARRANTIES.  The Company represents and warrants
to Lender that:

<PAGE>

         (a)  all interest in the Collateral held by the Company is owned by
the Company free and clear of any security interests, liens, encumbrances,
options or other restrictions;

         (b)  the Company has full power and authority to create a first lien
on the Collateral in favor of Lender and no disability or contractual obligation
exists that would prohibit the Company from pledging the Collateral pursuant to
this Security Agreement; and

         (c)  the Collateral is not the subject of any present or threatened
suit, action, arbitration, administrative or other proceeding, and the Company
knows of no reasonable grounds for the institution of any such proceedings.

     4.  COVENANTS.  The Company hereby covenants and agrees that for as long
as, and to the extent that, the security interest granted by this Security
Agreement shall continue and exist, without the advance written consent of
Lender, the Company shall:

         (a)  perform all of the Obligations according to their terms;

         (b)  defend the title to any interest of the Company in the Collateral
(to the extent such Collateral (i) has not been released pursuant to Section 7
or has been reinstated pursuant to Section 7 and (ii) is subject to any security
interest created by this Security Agreement) against all persons and against all
claims and demands whatsoever;

         (c)  immediately upon Lender's request, execute and deliver such
further instruments and documents, and take all such other action, as Lender
deems reasonably necessary or desirable to further evidence and perfect this
pledge and grant of security in the Collateral (to the extent such Collateral
(i) has not been released pursuant to Section 7 or has been reinstated pursuant
to Section 7 and (ii) is subject to any security interest created by this
Security Agreement);

         (d)  immediately upon demand of Lender, furnish further assurance of
title, execute any written agreement or do any other acts necessary to
effectuate the purposes and provisions of this Security Agreement, execute any
instrument or statement required by law or otherwise in order to perfect or
continue the security interest of the Lender in the Collateral (to the extent
such Collateral (i) has not been released pursuant to Section 7 or has been
reinstated pursuant to Section 7 and (ii) is subject to any security interest
created by this Security Agreement) or to terminate the security interest of the
Lender in the Collateral (to the extent such Collateral has been released
pursuant to Section 7 and is not subject to any security interest created by
this Agreement), and pay all costs of filing in connection therewith;

<PAGE>

         (e)  keep the Collateral (to the extent such Collateral (i) has not
been released pursuant to Section 7 or has been reinstated pursuant to Section 7
and (ii) is subject to any security interest created by this Security Agreement)
free and clear of all liens, charges, encumbrances, taxes and assessments, other
than the lien and security interest granted by this Security Agreement; and

         (f)  pay, when due, all taxes, assessments and license fees relating
to the Collateral (to the extent such Collateral (i) has not been released
pursuant to Section 7 or has been reinstated pursuant to Section 7 and (ii) is
subject to any security interest created by this Security Agreement).

Without limiting the generality of the foregoing, the Collateral shall be
deposited into and (until released pursuant to Section 7) maintained in an
account or accounts with financial institutions reasonably acceptable to Lender,
from which withdrawals, payments and transfers to the Company shall be made only
upon the joint signatures of a duly authorized representative of the Company and
a duly authorized representative of Lender, and the Company shall not withdraw,
cancel, redeem or seek the payment, release, delivery, or assignment of, or
transfer of any right, title or interest in, the Collateral (until released
pursuant to Section 7), to the extent that any portion of the Principal Amount
under the Note shall remain outstanding and shall not theretofore have been
converted into Common Stock or repaid.  The restrictions set forth in this
Section 4 shall not apply to any portion of the Collateral that has been
released pursuant to Section 7 and is not subject to a security interest
pursuant to this Agreement

    5.   AUTHORIZATION OF LENDER ACTION.  The Company irrevocably authorizes
and empowers Lender,

         (a)  at any time and from time to time after delivery by Lender of a
notice of an Event of Default, either in its own name or in the Company's name,
to:

              (i)     demand, collect, and receive payment of any and all
monies or proceeds represented by, or due with respect to, the Collateral;

              (ii)    execute any endorsements of the Collateral and any or all
instruments or documents for the withdrawal or repayment of some or all of same;

              (iii)   insert in any instrument or document utilized for the
withdrawal of funds represented by the Collateral signed by the Company the date
and amount due under the Collateral and to complete such instrument or document
in any respect Lender deems necessary or desirable;

              (iv)    deal in all respects with the Collateral as the holder
thereof, and the Company irrevocably constitutes and appoints Lender as its
attorney to do any and all things Lender deems necessary or desirable to effect
this Security

<PAGE>

Agreement and the enforcement of Lender's rights and remedies hereunder; and

         (b)  at any time and from time to time, either before or after the
delivery by Lender of a notice of an Event of Default, either in its own name or
in the Company's name, to:

              (i)     notify any issuer of Collateral of Lender's interest
therein; and

              (ii)    file all appropriate financing statements required to
perfect Lender's first lien and security interest in the Collateral.

    6.   DEFAULT AND REMEDIES.  Upon the occurrence of an Event of Default (as
defined in the Note), Lender may exercise all rights and remedies of a secured
party with respect to the Collateral.  After the disposal of any of the
Collateral, Lender may deduct all reasonable legal and other expenses and fees
for protecting its interests and enforcing its remedies under this Security
Agreement, the Purchase Agreement, and the other Transaction Documents, and
shall apply the residue of the proceeds to, or hold as a reserve against, the
Obligations in such manner as Lender, in its reasonable discretion, shall
determine, and shall pay the balance, if any to the Company.

    7.   RELEASE OF COLLATERAL.  The pledge of and grant of a security interest
in the Collateral pursuant to this Security Agreement (a) shall remain in effect
as long as, and to the extent that, any portion of the Principal Amount under
the Note shall remain outstanding and shall not theretofore have been converted
into Common Stock or repaid, and (b) shall be of no further force or effect, and
any previously unreleased Collateral shall be returned and released to the
Company, upon (i) the conversion of any previously unconverted portion of the
Note into Common Stock or the repayment of any previously unpaid Principal
Amount thereunder, and (ii) the performance of the Company's obligations under
the Note (including, without limitation, the Company's obligations under Section
1.1 of the Purchase Agreement) with respect to such total or partial conversion
or repayment.  In the event that a portion of the Note shall be converted into
Common Stock pursuant to Section 1.1 of the Purchase Agreement, a proportionate
portion of the Collateral shall be released to the Company.  Notwithstanding the
foregoing, and notwithstanding any other provision of this Security Agreement,
the security interest created by this Security Agreement shall be reinstated if
(and to the extent that) any payment must be returned by Lender, or is set
aside, for any reason, including, but not limited to, upon or after the
insolvency, bankruptcy or reorganization of the Company.


    8.   MISCELLANEOUS.

         (a)  WAIVERS AND AMENDMENTS.  This Security Agreement or any

<PAGE>



provision hereof may be amended, waived, discharged or terminated only by a
statement in writing signed by the party against which enforcement of the
amendment, waiver, discharge or termination is sought.

         (b)  SURVIVAL.  The representations, warranties, covenants and
agreements made herein shall survive the making of this Security Agreement, the
Purchase Agreement and the other Transaction Documents and the closing of the
transactions contemplated hereby and thereby, notwithstanding any investigation
made by Lender.  All statements as to factual matters contained in any
certificate delivered by or on behalf of a party pursuant hereto or in
connection with the transactions contemplated hereby shall be deemed to be
representations and warranties by such party hereunder as of the date of such
certificate or instrument.

         (c)  SUCCESSORS AND ASSIGNS.  Except as expressly provided or
contemplated by this Security Agreement and the exhibits hereto, neither this
Security Agreement nor the rights, obligations or interests hereunder shall be
assigned by either party hereto (other than by operation of law) without the
prior written consent of the other party; PROVIDED, that nothing herein shall
prevent or limit the ability of Lender to assign any or all of its rights under
this Security Agreement to an affiliate of Lender.  Subject to the foregoing
limitations, the provisions hereof shall inure to the benefit of, and be binding
upon and enforceable by, the parties hereto and their respective successors and
assigns.

         (d)  ENTIRE AGREEMENT.  This Security Agreement together with the
Purchase Agreement, the other Transaction Documents and the other instruments
delivered pursuant hereto or thereto constitute the full and entire
understanding and agreement between the parties with regard to the subjects
hereof and thereof and supersede all prior and contemporaneous agreements,
understandings, negotiations and discussions, whether oral or written, of the
parties with respect thereto.

<PAGE>

         (e)  NOTICES.  All notices and other communications required or
permitted hereunder shall be in writing and shall be delivered personally or by
overnight courier or mailed by first class mail, or Express Mail, postage
prepaid, or via facsimile, delivered as follows:

    (i)  if to Lender, to:

         Tako Ventures, LLC
         c/o Mr. Philip Simon
         Howson & Simon L.P.
         220 Montgomery Street
         Suite 1041
         San Francisco, CA 94104

         with copies to:

         Springs, Rivin, Detwiler, Dudnick & Stikker
         351 California Street
         Suite 1041
         San Francisco, CA 94104
         Attention:  Andrew Dudnick, Esq.

         Gray Cary Ware & Freidenrich
         A Professional Corporation
         400 Hamilton Avenue
         Palo Alto, CA 94301
         Attention:  Rod J. Howard, Esq. & Brad J. Rock, Esq.

         or at such other address as Lender shall have furnished to the Company
         in writing,

    (ii) if to the Company, to:

         SuperGen, Inc.
         Two Annabel Lane, Suite 220
         San Ramon, CA 94583

<PAGE>

         with a copy to:

         Wilson Sonsini Goodrich & Rosati,
         Professional Corporation
         650 Page Mill Road
         Palo Alto, California 94304-1050
         Attention: John Roos, Esq. and Page Mailliard, Esq.

         or at such other address as the Company shall have furnished to Lender
         in writing.

Notices that are mailed by (i) first class mail shall be deemed received three
(3) business days after deposit in the mail and (ii) Express Mail or overnight
courier shall be deemed received one (1) business day after deposit in the mail.
In the event that the notice is sent by facsimile, notice shall be deemed to
have been received when sent and confirmed as to receipt.

         (f)  SEVERABILITY.  In case any provision of this Security Agreement
shall be invalid, illegal or unenforceable, the validity, legality and
enforceability of the remaining provisions of this Security Agreement shall not
in any way be affected or impaired thereby.

         (g)  INTERPRETATION.  Captions and titles of sections of this Security
Agreement are for convenience of reference only and are not to be considered in
construing this Security Agreement.  When reference is made in this Security
Agreement to a "section", such reference shall be to a section of this Security
Agreement unless otherwise specified.  Whenever the words "include", "includes",
or "including" are used in this Security Agreement they shall be deemed to be
followed by the words "without limitation."  The words "herein," "hereof" and
words of similar import refer to this Security Agreement as a whole, and not to
any single provision thereof.

         (h)  COUNTERPARTS.  This Security Agreement may be executed in any
number of counterparts, each of which shall be an original, but all of which
together shall constitute one instrument.

         (i)  DELAYS OR OMISSIONS.  No delay or omission to exercise any right,
power or remedy accruing to the Company or to Lender shall impair any such
right, power or remedy of the Company or Lender, nor shall it be construed to be
a waiver of any breach or default under this Security Agreement, or an
acquiescence therein, or of or in any similar breach or default thereafter
occurring; nor shall any delay or omission to exercise any right, power or
remedy or any waiver of any single breach or default be deemed a waiver of any
other right, power or remedy or breach or default theretofore or thereafter
occurring.  All remedies, either under this Security Agreement, or by law
otherwise afforded to the Company or Lender, shall be

<PAGE>

cumulative and not alternative.

         (j)  GOVERNING LAW/VENUE.  THIS SECURITY AGREEMENT SHALL BE DEEMED A
CONTRACT AND INSTRUMENT MADE UNDER THE LAWS OF THE STATE OF CALIFORNIA AND SHALL
BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE
STATE OF CALIFORNIA AND THE LAWS OF THE UNITED STATES OF AMERICA.  THE COMPANY
HEREBY IRREVOCABLY SUBMITS ITSELF TO THE EXCLUSIVE JURISDICTION OF THE STATE AND
FEDERAL COURTS OF THE STATE OF CALIFORNIA LOCATED IN THE CITY OF SAN FRANCISCO
AND AGREES AND CONSENTS THAT SERVICE OF PROCESS MAY BE MADE UPON IT IN ANY LEGAL
PROCEEDING RELATING TO THIS SECURITY AGREEMENT OR THE OBLIGATIONS GUARANTEED BY
THIS SECURITY AGREEMENT BY ANY MEANS ALLOWED UNDER CALIFORNIA OR FEDERAL LAW.
VENUE FOR ANY LEGAL PROCEEDING MAY BE IN SAN FRANCISCO COUNTY, CALIFORNIA.

         (k)  LEGAL COUNSEL.  THE COMPANY ACKNOWLEDGES THAT IT HAS BEEN
REPRESENTED BY INDEPENDENT LEGAL COUNSEL IN CONNECTION WITH ALL MATTERS
CONCERNING THIS SECURITY AGREEMENT, INCLUDING, BUT NOT LIMITED TO, THE
NEGOTIATION, ACCEPTANCE AND EXECUTION OF THIS SECURITY AGREEMENT; THAT THE
COMPANY HAS RELIED UPON THE ADVICE OF ITS INDEPENDENT LEGAL COUNSEL IN AGREEING
TO THE TERMS AND CONDITIONS HEREIN AND IN EXECUTING THIS SECURITY AGREEMENT; AND
THAT IT HAS FREELY AND VOLUNTARILY ENTERED INTO THIS SECURITY AGREEMENT AS THE
PRODUCT OF ARMS LENGTH NEGOTIATIONS.

         (l)  WAIVER OF JURY TRIAL.  THE COMPANY AND LENDER EACH HEREBY WAIVE
ANY RIGHT TO TRIAL BY JURY OF ANY CLAIM, DEMAND, ACTION, CAUSE OF ACTION, SUIT
OR PROCEEDINGS (1) ARISING UNDER THIS SECURITY AGREEMENT OR ANY OTHER
INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION HEREWITH
OR (2) IN ANY WAY CONNECTED WITH OR RELATED TO OR INCIDENTAL TO THE DEALINGS OF
THE PARTIES HERETO OR ANY OF THEM WITH RESPECT TO THIS SECURITY AGREEMENT, THE
PURCHASE AGREEMENT OR ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR
DELIVERED IN CONNECTION HEREWITH OR THE TRANSACTIONS RELATED HERETO, IN EACH
CASE WHETHER NOW EXISTING OR HEREAFTER ARISING, AND WHETHER SOUNDING IN
CONTRACT, TORT OR OTHERWISE.  THE COMPANY AND LENDER HEREBY AGREE AND CONSENT
THAT ANY SUCH CLAIM, DEMAND, ACTION, CAUSE OF ACTION, SUIT OR PROCEEDING SHALL
BE DECIDED BY A COURT TRIAL, WITHOUT A JURY, AND THAT EITHER PARTY MAY FILE AN
ORIGINAL COUNTERPART OR COPY OF THIS SECURITY AGREEMENT WITH ANY COURT AS
WRITTEN EVIDENCE OF THE CONSENT OF THE PARTIES HERETO TO THE

<PAGE>

WAIVER OF THEIR RIGHT TO TRIAL BY JURY.

<PAGE>

    IN WITNESS WHEREOF, the parties hereto have executed this Security
Agreement as of the date as of the date first written above.

                             SUPERGEN, INC.



                             By:  /s/ Dr. Joseph Rubinfeld
                                  -----------------------------
                                  Name:  Dr. Joseph Rubinfeld
                                  Title: Chief Executive Officer
                                         President and Chief
                                         Executive Officer

                             TAKO VENTURES, LLC

                             By  CEPHALOPOD CORPORATION,
                                   Member


                                  By: /s/ Philip B. Simon
                                     --------------------------
                                        Philip B. Simon
                                        President

<PAGE>

                                       ANNEX A



[List certificates of deposit and accounts]

<PAGE>

                                 EXHIBIT 6
                                 ---------

     The attached form of Shareholder Agreement was made and entered into as 
of June 17, 1997 by and between Tako Ventures, LLC, and the following 
shareholders of SuperGen, Inc.: (i) Rajesh C. Shrotriya, (ii) Henry C. 
Settle Jr., (iii) Frank Brenner, (iv) Francis Lee, (v) R. David Lauper, (vi) 
Simeon M. Wrenn, (vii) Christine A. Carey, and (viii) Fred Grab.

<PAGE>

                              SHAREHOLDER AGREEMENT

     THIS SHAREHOLDER AGREEMENT is made and entered into as of June 17, 1997 by
and between Tako Ventures, LLC, a California limited liability company
("PURCHASER"), and the undersigned shareholder ("SHAREHOLDER") of SuperGen,
Inc., a California corporation ("SUPERGEN").  Capitalized terms not otherwise
defined herein shall have the meanings ascribed to them in the Convertible
Secured Note, Option and Warrant Purchase Agreement by and among SuperGen,
Purchaser and, solely for purposes of Sections 5.3 and 5.5 thereof, Lawrence J.
Ellison dated as of June 17, 1997 (the "PURCHASE AGREEMENT").

                                    RECITALS

     Pursuant to the Purchase Agreement, Purchaser has agreed, subject to
certain conditions precedent, to acquire certain securities convertible into or
exerciseable for shares of common stock, par value $.001 per share of SuperGen
("SUPERGEN COMMON STOCK").  It is a condition to Purchaser's obligation to
purchase the Convertible Secured Note contemplated by the Purchase Agreement
that, at or prior to the Note Closing thereunder, this Shareholder Agreement
shall have been executed by Shareholder and delivered to Purchaser, and that
this Shareholder Agreement shall be in full force and effect.  The execution and
delivery of this Shareholder Agreement by Shareholder is a material inducement
to Purchaser to enter into the Purchase Agreement.  As the record holder and
beneficial owner (as defined in Rule 13d-3 under the Securities Exchange Act of
1934, as amended) of the number of shares (and options to acquire shares) of
SuperGen Common Stock set forth on the signature page of this Shareholder
Agreement, Shareholder believes that the transactions contemplated by the
Purchase Agreement are in the interests and to the benefit of the Company, and
that it is therefore in the personal interest and to the personal benefit of
Shareholder to induce Purchaser to enter into the Purchase Agreement.

     NOW, THEREFORE, in consideration of the mutual covenants and agreements
contained herein, and for other good and valuable consideration the receipt and
sufficiency of which are hereby acknowledged, the parties agree as follows:

                                    AGREEMENT

     1.   ACKNOWLEDGMENTS BY SHAREHOLDER.  Shareholder acknowledges and
understands that the representations, warranties and covenants made by
Shareholder set forth herein will be relied upon by Purchaser, and that
substantial losses and damages may be incurred by Purchaser if Shareholder's
representations, warranties or covenants are breached.  Shareholder has
carefully read this Shareholder Agreement and the Purchase Agreement and has
consulted with such legal counsel and financial advisers as Shareholder has
deemed appropriate in connection with the execution of this Shareholder
Agreement.



<PAGE>

     2.   RESTRICTIONS ON SALE AND OTHER TRANSACTIONS; LEGEND.

          (a)  Prior to 11:59 p.m. October 31, 1998 (the "EXPIRATION DATE"),
Shareholder shall not sell (or permit to be sold), exchange, transfer, pledge
(except in connection with margin loans in an aggregate principal amount not to
exceed thirty percent (30%) of the "current market value" of the pledged
securities as defined in applicable federal margin regulations), distribute or
otherwise dispose of, or grant any option with respect to, establish any "short"
or put-equivalent position with respect to, or otherwise enter into any
agreement, arrangement, transaction or series of transactions (through
derivatives or otherwise) which has or is intended to have the effect, directly
or indirectly, of reducing Shareholder's risk of ownership (each of the
foregoing, a "RESTRICTED TRANSACTION" and collectively, the "RESTRICTED
TRANSACTIONS") in, more than fifteen percent (15%) of the shares of SuperGen
Common Stock owned beneficially or of record, or purchasable by Shareholder
pursuant to options, warrants and other securities outstanding, as of the date
of this Agreement.  In determining compliance with the foregoing percentage
limitation, adjustment shall be made for any stock split, stock dividend,
subdivision, combination, recapitalization, reclassification, or other
transaction within the scope of Section 1.3 of the Purchase Agreement, in
accordance with the terms thereof.  Notwithstanding the foregoing provisions,
(a) if Shareholder's employment with SuperGen and its subsidiaries is
voluntarily terminated by Shareholder, Shareholder shall be permitted and
entitled to sell such further shares of SuperGen Common Stock as may be required
to pay any taxes imposed on any exercise of options to purchase SuperGen Common
Stock; (b) if Shareholder's employment with SuperGen and its subsidiaries is
terminated involuntarily and without "Cause" (as defined below), Shareholder
shall be permitted and entitled to sell, in excess of sales permitted under the
15% limitation above, any or all shares of SuperGen Common Stock purchasable
pursuant to options held by Shareholder at the time of such termination; and
(c) all restrictions on Shareholder under this Agreement shall immediately and
automatically cease and terminate in the event of Shareholder's death.  For
purposes of this provision, the term "Cause" shall mean (i) failure to perform
reasonably assigned duties, (ii) commission of any act of gross misconduct which
is injurious to SuperGen or any of its subsidiaries or contrary to important
announced policies of SuperGen and its subsidiaries, (iii) commission of any
unlawful or fraudulent act, or (iv) breach of any confidentiality or proprietary
information agreement with or obligation to SuperGen or any of its subsidiaries.

          (b)  SuperGen shall give stop transfer instructions to its transfer
agent with respect to any SuperGen Common Stock owned beneficially or of record
by Shareholder, or issued to Shareholder upon exercise of any option, warrant or
other security outstanding, as of the date hereof, and there shall be placed on
the certificates representing such SuperGen Common Stock, or any substitutions
therefor, a legend stating in substance:

          "PRIOR TO NOVEMBER 1, 1998, THE SHARES REPRESENTED BY THIS CERTIFICATE
     MAY NOT BE OFFERED, SOLD, EXCHANGED, TRANSFERRED, PLEDGED (EXCEPT IN
     CONNECTION WITH MARGIN LOANS IN AN AGGREGATE PRINCIPAL AMOUNT NOT TO EXCEED
     30% OF THE "CURRENT MARKET VALUE" OF THE PLEDGED SECURITIES AS DEFINED IN
     APPLICABLE FEDERAL MARGIN REGULATIONS), DISTRIBUTED, OR


                                        2
<PAGE>

     OTHERWISE DISPOSED OF, AND NO OPTION SHALL BE GRANTED WITH RESPECT TO SUCH
     SHARES, NO "SHORT" OR PUT-EQUIVALENT POSITION SHALL BE ESTABLISHED WITH
     RESPECT TO SUCH SHARES, AND NO OTHER AGREEMENT, ARRANGEMENT TRANSACTION OR
     SERIES OF TRANSACTIONS SHALL BE MADE AFFECTING SUCH SHARES (THROUGH
     DERIVATIVES OR OTHERWISE) WHICH HAS OR IS INTENDED TO HAVE THE EFFECT,
     DIRECTLY OR INDIRECTLY, OF REDUCING THE RISK OF OWNERSHIP OF SUCH SHARES,
     EXCEPT IN ACCORDANCE WITH THE REQUIREMENTS OF THE CONDITIONS SPECIFIED IN
     THE SHAREHOLDER AGREEMENT DATED AS OF JUNE 17, 1997 BETWEEN THE HOLDER OF
     THIS CERTIFICATE AND TAKO VENTURES, LLC, A COPY OF WHICH AGREEMENT MAY BE
     INSPECTED BY THE HOLDER OF THIS CERTIFICATE AT THE PRINCIPAL OFFICES OF
     SUPERGEN OR FURNISHED BY SUPERGEN TO THE HOLDER OF THIS CERTIFICATE UPON
     WRITTEN REQUEST AND WITHOUT CHARGE."

          (c)  In the event that Shareholder shall propose to engage in a
Restricted Transaction, (i) Shareholder shall deliver to Purchaser and SuperGen
a notice (the "NOTICE OF PROPOSED DISPOSITION"), setting forth (A) the number of
shares of SuperGen Common Stock owned beneficially or of record by Shareholder,
or purchasable by Shareholder pursuant to options, warrants and other securities
outstanding, as of the date hereof; (B) the nature and amount of any adjustments
within the scope of Section 1.3 of the Purchase Agreement; (C) the nature of the
proposed Restricted Transaction and the number of shares of SuperGen Common
Stock covered thereby; and (D) the number of shares of SuperGen Common Stock as
to which Restricted Transactions have previously been effected and the nature of
the Restricted Transactions effected with respect to such shares; and (ii)
SuperGen shall deliver to Purchaser a certificate of an appropriate officer of
SuperGen (the "CERTIFICATE OF COMPLIANCE") to the effect that such proposed
Restricted Transaction complies with the limitations set forth in Section 2(a)
of this Shareholder Agreement.  The legend set forth above shall thereafter be
removed, and an unlegended certificate shall be issued, as to the number of
shares of SuperGen Common Stock covered by such Notice of Proposed Disposition
and Certificate of Compliance, and SuperGen shall instruct its transfer agent to
effect the transfer of such shares as proposed in the Notice of Proposed
Disposition.  Notwithstanding any other provision of this Shareholder Agreement,
the legend set forth above shall be removed to the extent Shareholder shall have
certified to Purchaser and the Company that such removal is necessary to permit
Shareholder to pledge the legended shares of SuperGen Common Stock in connection
with a margin loan authorized by this Shareholder Agreement.  All other shares
owned beneficially or of record by Shareholder shall continue to bear the legend
set forth above and a substitute certificate therefore shall be delivered to
Shareholder.

          (d)  If Shareholder pledges any shares of SuperGen Common Stock as
collateral for any margin loan, Shareholder shall (i) at all times prior to the
Expiration Date maintain sufficient collateral for, and shall meet all margin
calls (if any) made with respect to, each such loan, and (ii) provide (or cause
Shareholder's broker to provide) a copy of Shareholder's monthly margin account
statements to the Chief Financial Officer or Controller of SuperGen, who


                                        3
<PAGE>

shall be required to give prompt notice to Purchaser of any noncompliance by
Shareholder with the margin loan limitations or Restricted Transaction
limitations set forth in this Agreement.  Shareholder acknowledges and agrees
that if any shares of SuperGen Common Stock pledged by Shareholder are sold to
meet a margin call or to satisfy any obligations of Shareholder relating to such
loan, such shares shall count toward the limitations set forth in Section 2(a),
and Shareholder shall promptly provide notice to Purchaser and the Company of
the number of shares so sold.  All notices hereunder shall be given in
accordance with the notice provisions of Section 8.7 of the Purchase Agreement.

     3.   MISCELLANEOUS.

          (a)  This Shareholder Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same document.

          (b)  This Shareholder Agreement shall be enforceable by, and shall
inure to the benefit of and be binding upon, the parties hereto and their
respective successors and assigns.  As used herein, the term "successors and
assigns" shall mean, where the context so permits, heirs, executors,
administrators, trustees and successor trustees, and personal and other
representatives.

          (c)  This Shareholder Agreement shall be governed by and construed,
interpreted and enforced in accordance with the internal laws of the state of
incorporation (or reincorporation, as the case may be) of SuperGen applicable to
agreements made and performed wholly within such state.  Each party hereto
irrevocably and unconditionally consents and submits to the jurisdiction of the
courts of the State of California and of the United States of America located in
the City of San Francisco for any actions, suits or proceedings arising out of
or relating to this Shareholder Agreement and the transactions contemplated
hereby.

          (d)  If any provision of this Shareholder Agreement is held to be
unenforceable for any reason, it shall be modified rather than voided, if
possible, in order to achieve the intent of the parties to the extent possible.
In any event, all other provisions of this Shareholder Agreement shall be deemed
valid and enforceable to the extent possible.

          (e)  This Shareholder Agreement shall not be modified or amended, or
any right hereunder waived or any obligation excused, except by a written
agreement signed by both parties.

          (f)  This Shareholder Agreement shall terminate in the event of a
merger, consolidation, share exchange or other reorganization or business
combination transaction in which the Company voting securities held by
shareholders of the Company immediately prior to the effective time of such
transaction shall represent less than a majority of the voting power of the
surviving, resulting or acquiring entity.


                                        4
<PAGE>

     IN WITNESS WHEREOF, this Shareholder Agreement is executed as of the date
first shown above.

                                   TAKO VENTURES, LLC
                                   a California limited liability company

                                   By: CEPHALOPOD CORPORATION,
                                       Member


                                        By: 
                                            -----------------------------------
                                             Philip B. Simon
                                             President


                                   SUPERGEN, INC.
                                   a California corporation


                                   By:
                                       ----------------------------------------
                                         Name:
                                         Title:

                                   SHAREHOLDER

                                   By:
                                       ----------------------------------------

                                   Name of Shareholder:
                                                        -----------------------
                                   Name of Signatory
                                   (if different from name of Shareholder):

                                   --------------------------------------------

                                   Title of Signatory
                                   (if applicable):
                                                    ---------------------------

                                   Number of shares of SuperGen Common Stock
                                   owned as of the date hereof:
                                                                ---------------

                                   Number of shares of SuperGen Common Stock 
                                   issuable upon exercise of stock options 
                                   owned as of the date hereof:
                                                                ------------

                                        5

<PAGE>

                                  EXHIBIT 7
                                  ---------

     The attached form of Shareholder Agreement was made and entered into as 
of June 17, 1997 by and between Tako Ventures, LLC and the following 
shareholders of SuperGen, Inc.: (i) Joseph Rubinfeld, Ph.D., (ii) David M. 
Fineman, (iii) Elliott Fineman, and (iv) Greg Swendsen.

<PAGE>

                                SHAREHOLDER AGREEMENT


    THIS SHAREHOLDER AGREEMENT is made and entered into as of June 17, 1997 by
and between Tako Ventures, LLC, a California limited liability company
("PURCHASER"), and [Joseph Rubinfeld, Ph.D., David M. Fineman, Elliott Fineman,
Greg Swendsen] ("SHAREHOLDER"), a Shareholder of SuperGen, Inc., a California
corporation ("SUPERGEN").  Capitalized terms not otherwise defined herein shall
have the meanings ascribed to them in the Convertible Secured Note, Option and
Warrant Purchase Agreement by and among SuperGen, Purchaser and, solely for
purposes of Sections 5.3 and 5.5 thereof, Lawrence J. Ellison dated as of
June 17, 1997 (the "PURCHASE AGREEMENT").

                                       RECITALS

    Pursuant to the Purchase Agreement, Purchaser has agreed, subject to
certain conditions precedent, to acquire certain securities convertible into or
exerciseable for shares of common stock, par value $.001 per share, of SuperGen
("SUPERGEN COMMON STOCK").  It is a condition to Purchaser's obligation to
purchase the Convertible Secured Note contemplated by the Purchase Agreement
that, at or prior to the Note Closing thereunder, this Shareholder Agreement
shall have been executed by Shareholder and delivered to Purchaser, and that
this Shareholder Agreement shall be in full force and effect.  The execution and
delivery of this Shareholder Agreement by Shareholder is a material inducement
to Purchaser to enter into the Purchase Agreement.  As the record holder and
beneficial owner (as defined in Rule 13d-3 under the Securities Exchange Act of
1934, as amended) of the number of shares (and options to acquire shares) of
SuperGen Common Stock set forth on the signature page of this Shareholder
Agreement, Shareholder believes that the transactions contemplated by the
Purchase Agreement are in the interests and to the benefit of the Company, and
that it is therefore in the personal interest and to the personal benefit of
Shareholder to induce Purchaser to enter into the Purchase Agreement.

    NOW, THEREFORE, in consideration of the mutual covenants and agreements
contained herein, and for other good and valuable consideration the receipt and
sufficiency of which are hereby acknowledged, the parties agree as follows:

                                      AGREEMENT

         ACKNOWLEDGMENTS BY SHAREHOLDER.  Shareholder acknowledges and
understands that the representations, warranties and covenants made by
Shareholder set forth herein will be relied upon by Purchaser, and that
substantial losses and damages may be incurred by Purchaser if Shareholder's
representations, warranties or covenants are breached.  Shareholder has
carefully read this Shareholder Agreement and the Purchase Agreement and has
consulted with such legal counsel and financial advisers as Shareholder has
deemed appropriate in connection with the execution of this Shareholder
Agreement.


                                         -1-
<PAGE>

    2.   RESTRICTIONS ON SALE AND OTHER TRANSACTIONS; LEGEND.

         (a)  Prior to 11:59 p.m. October 31, 1998 (the "EXPIRATION DATE"),
Shareholder shall not sell (or permit to be sold), exchange, transfer, pledge
(except in connection with margin loans in an aggregate principal amount not to
exceed thirty percent (30%) of the "current market value" of the pledged
securities as defined in applicable federal margin regulations), distribute or
otherwise dispose of, or grant any option with respect to, establish any "short"
or put-equivalent position with respect to, or otherwise enter into any
agreement, arrangement, transaction or series of transactions (through
derivatives or otherwise) which has or is intended to have the effect, directly
or indirectly, of reducing Shareholder's risk of ownership (each of the
foregoing, a "RESTRICTED TRANSACTION" and collectively, the "RESTRICTED
TRANSACTIONS") in, more than three hundred fifty thousand (350,000) of the
shares of SuperGen Common Stock owned beneficially or of record, or purchasable
by Shareholder pursuant to options, warrants and other securities outstanding,
as of the date hereof.  The foregoing restrictions shall immediately and
automatically cease in the event of Shareholder's death.  In determining
compliance with the foregoing percentage limitation, adjustment shall be made
for any stock split, stock dividend, subdivision, combination, recapitalization,
reclassification, or other transaction within the scope of Section 1.3 of the
Purchase Agreement, in accordance with the terms thereof.

         (b)  SuperGen shall give stop transfer instructions to its transfer
agent with respect to any SuperGen Common Stock owned beneficially or of record
by Shareholder, or issued to Shareholder upon exercise of any option, warrant or
other security outstanding, as of the date hereof, and there shall be placed on
the certificates representing such SuperGen Common Stock, or any substitutions
therefor, a legend stating in substance:

    "PRIOR TO NOVEMBER 1, 1998, THE SHARES REPRESENTED BY THIS CERTIFICATE MAY
    NOT BE OFFERED, SOLD, EXCHANGED, TRANSFERRED, PLEDGED, (EXCEPT IN
    CONNECTION WITH MARGIN LOANS IN AN AGGREGATE PRINCIPAL AMOUNT NOT TO EXCEED
    30% OF THE "CURRENT MARKET VALUE" OF THE PLEDGED SECURITIES AS DEFINED IN
    APPLICABLE FEDERAL MARGIN REGULATIONS) DISTRIBUTED, OR OTHERWISE DISPOSED
    OF, AND NO OPTION SHALL BE GRANTED WITH RESPECT TO SUCH SHARES, NO "SHORT"
    OR PUT-EQUIVALENT POSITION SHALL BE ESTABLISHED WITH RESPECT TO SUCH
    SHARES, AND NO OTHER AGREEMENT, ARRANGEMENT TRANSACTION OR SERIES OF
    TRANSACTIONS SHALL BE MADE AFFECTING SUCH SHARES (THROUGH DERIVATIVES OR
    OTHERWISE) WHICH HAS OR IS INTENDED TO HAVE THE EFFECT, DIRECTLY OR
    INDIRECTLY, OF REDUCING THE RISK OF OWNERSHIP OF SUCH SHARES, EXCEPT IN
    ACCORDANCE WITH THE REQUIREMENTS OF THE CONDITIONS SPECIFIED IN THE
    SHAREHOLDER AGREEMENT DATED AS OF JUNE 17, 1997 BETWEEN THE HOLDER OF THIS
    CERTIFICATE AND TAKO VENTURES, LLC, A COPY OF WHICH AGREEMENT MAY BE
    INSPECTED BY THE HOLDER OF THIS CERTIFICATE AT THE PRINCIPAL OFFICES OF
    SUPERGEN OR FURNISHED BY SUPERGEN TO THE HOLDER OF THIS CERTIFICATE UPON
    WRITTEN REQUEST AND WITHOUT CHARGE."


                                         -2-
<PAGE>

         (c)  In the event that Shareholder shall propose to engage in a
Restricted Transaction, (i) Shareholder shall deliver to Purchaser and SuperGen
a notice (the "NOTICE OF PROPOSED DISPOSITION"), setting forth (A) the number of
shares of SuperGen Common Stock owned beneficially or of record by Shareholder,
or purchasable by Shareholder pursuant to options, warrants and other securities
outstanding, as of the date hereof; (B) the nature and amount of any adjustments
within the scope of Section 1.3 of the Purchase Agreement; (C) the nature of the
proposed Restricted Transaction and the number of shares of SuperGen Common
Stock covered thereby; and (D) the number of shares of SuperGen Common Stock as
to which Restricted Transactions have previously been effected and the nature of
the Restricted Transactions effected with respect to such shares; and
(ii) SuperGen shall deliver to Purchaser a certificate of an appropriate officer
of SuperGen (the "CERTIFICATE OF COMPLIANCE") to the effect that such proposed
Restricted Transaction complies with the limitations set forth in Section 2(a)
of this Shareholder Agreement.  The legend set forth above shall thereafter be
removed, and an unlegended certificate shall be issued, as to the number of
shares of SuperGen Common Stock covered by such Notice of Proposed Disposition
and Certificate of Compliance, and SuperGen shall instruct its transfer agent to
effect the transfer of such shares as proposed in the Notice of Proposed
Disposition.  Notwithstanding any other provision of this Shareholder Agreement,
the legend set forth above shall be promptly removed (or the placement of such
legend shall be waived) to the extent Shareholder shall have certified to
Purchaser and the Company that such removal or waiver is necessary to permit
Shareholder to pledge the legended shares of SuperGen Common Stock in connection
with a margin loan authorized by this Shareholder Agreement.  All other shares
owned beneficially or of record by Shareholder shall continue to bear the legend
set forth above and a substitute certificate therefore shall be delivered to
Shareholder.

         (d)  If Shareholder pledges any shares of SuperGen Common Stock as
collateral for any margin loan, Shareholder shall (i) at all times prior to the
Expiration Date maintain sufficient collateral for, and shall meet all margin
calls (if any) made with respect to, each such loan, and (ii) provide (or cause
Shareholder's broker to provide) a copy of Shareholder's monthly margin account
statements to the Chief Financial Officer or Controller of SuperGen, who shall
be required to give prompt notice to Purchaser of any noncompliance by
Shareholder with the margin limitations or Restricted Transaction limitations
set forth in this Agreement.  Shareholder acknowledges and agrees that if any
shares of SuperGen Common Stock pledged by Shareholder are sold to meet a margin
call or to satisfy any obligations of Shareholder relating to such loan, such
shares shall count toward the limitations set forth in Section 2(a), and
Shareholder shall promptly provide notice to Purchaser and the Company of the
number of shares so sold.  All notices hereunder shall be given in accordance
with the notice provisions of Section 8.7 of the Purchase Agreement.

    3.   MISCELLANEOUS.

         (a)  This Shareholder Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same document.


                                         -3-
<PAGE>

         (b)  This Shareholder Agreement shall be enforceable by, and shall
inure to the benefit of and be binding upon, the parties hereto and their
respective successors and assigns.  As used herein, the term "successors and
assigns" shall mean, where the context so permits, heirs, executors,
administrators, trustees and successor trustees, and personal and other
representatives.

         (c)  This Shareholder Agreement shall be governed by and construed,
interpreted and enforced in accordance with the internal laws of the state of
incorporation (or reincorporation, as the case may be) of SuperGen applicable to
agreements made and preformed wholly within such state.  Each party hereto
irrevocably and unconditionally consents and submits to the jurisdiction of the
courts of the State of California and of the United States of America located in
the City of San Francisco for any actions, suits or proceedings arising out of
or relating to this Shareholder Agreement and the transactions contemplated
hereby.

         (d)  If any provision of this Shareholder Agreement is held to be
unenforceable for any reason, it shall be modified rather than voided, if
possible, in order to achieve the intent of the parties to the extent possible.
In any event, all other provisions of this Shareholder Agreement shall be deemed
valid and enforceable to the extent possible.

         (e)  This Shareholder Agreement shall not be modified or amended, or
any right hereunder waived or any obligation excused, except by a written
agreement signed by both parties.

         (f)  This Shareholder Agreement shall terminate in the event of a
merger, consolidation, share exchange or other reorganization or business
combination transaction in which the Company voting securities held by
shareholders of the Company immediately, prior to the effective time of such
transaction shall represent less than a majority of the voting power of the
surviving, resulting or acquiring entity.


                                         -4-
<PAGE>

    IN WITNESS WHEREOF, this Shareholder Agreement is executed as of the date
first shown above.
                                       TAKO VENTURES, LLC
                                       a California limited liability company

                                       By   CEPHALOPOD CORPORATION,
                                            Member


                                          By: 
                                              -------------------------------
                                              Philip B. Simon
                                              President


                                       SUPERGEN, INC.
                                       a California corporation


                                       By:
                                          -----------------------------------
                                          Name:
                                          Title:

                                       SHAREHOLDER

                                       By:
                                          -----------------------------------

                                       Name of Shareholder:
                                                           ------------------
                                       Name of Signatory
                                       (if different from name of Shareholder):
                                       --------------------------------------


                                       Title of Signatory
                                       (if applicable):
                                                       ----------------------

                                       Number of shares of SuperGen Common
                                       Stock owned as  the date
                                       hereof:
                                              ---------

                                       Number of Shares of SuperGen Common
                                       Stock issuable upon exercise of stock
                                       options owned as of the date
                                       hereof:
                                              ---------


                                         -5-

<PAGE>

                                JOINT FILING AGREEMENT

    WHEREAS, the statement on Schedule 13D to which this agreement is an
exhibit (the "Joint Statement") is being filed on behalf of two or more persons
(collectively, the "Reporting Persons"); and

    WHEREAS, the Reporting Persons prefer to file the Joint Statement on behalf
of all Reporting Persons rather than individual statements on Schedule 13D on
behalf of each of the Reporting Persons;

    NOW, THEREFORE, the undersigned hereby agree as follows with each of the
other Reporting Persons:

    1.   Each of the Reporting Persons is individually eligible to use the
Joint Statement.

    2.   Each of the Reporting Persons is responsible for the timely filing of
the Joint Statement and any amendments thereto.

    3.   Each of the Reporting Persons is responsible for the completeness and
accuracy of the information concerning such person contained in the Joint
Statement.

    4.   None of the Reporting Persons is responsible for the completeness or
accuracy of the information concerning the other Reporting Persons contained in
the Joint Statement, unless such person knows or has reason to believe that such
information is inaccurate.

    5.   The undersigned agree that the Joint Statement is, and any amendment
thereto will be, filed on behalf of each of the Reporting Persons.

Dated  June 27, 1997
     ------------------------

TAKO VENTURES, LLC                     CEPHALOPOD CORPORATION
By: Cephalopod Corporation             
                                       /s/ Philip B. Simon
    By: /s/ Philip B. Simon            ------------------------------
       ----------------------          By:  Philip B. Simon
         Name:  Philip B. Simon        Its: President
         Title: President

LAWRENCE INVESTMENTS, LLC

/s/ Philip B. Simon                    /s/ Lawrence J. Ellison
- ------------------------------         ------------------------------
By:   Philip B. Simon                  Lawrence J. Ellison
Its:  Member


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