SUPERGEN INC
POS AM, 1997-11-05
PHARMACEUTICAL PREPARATIONS
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<PAGE>
   
    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON NOVEMBER 5, 1997
    
 
                                                     REGISTRATION NO. 333-476-LA
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------
 
                                 POST-EFFECTIVE
 
   
                                AMENDMENT NO. 3
    
 
                                  ON FORM S-3
 
                                       TO
 
                                   FORM SB-2
 
                             REGISTRATION STATEMENT
 
                                     UNDER
 
                           THE SECURITIES ACT OF 1933
                            ------------------------
 
                                 SUPERGEN, INC.
 
                 (Name of small business issuer in its charter)
 
   
<TABLE>
<S>                              <C>                            <C>
           DELAWARE                          2834                  97-1841574
 (State or other jurisdiction    (Primary Standard Industrial   (I.R.S. Employer
              of                 Classification Code Number)     Identification
incorporation or organization)                                      Number)
</TABLE>
    
 
            TWO ANNABEL LANE, SUITE 220, SAN RAMON, CALIFORNIA 94583
                                 (510) 327-0200
 
         (Address and telephone number of principal executive offices)
 
                            ------------------------
 
            JOSEPH RUBINFELD, PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                 SUPERGEN, INC.
                          TWO ANNABEL LANE, SUITE 220
                          SAN RAMON, CALIFORNIA 94583
                                 (510) 327-0200
 
           (Name, address, and telephone number of agent for service)
                            ------------------------
 
                                   COPIES TO:
                               JOHN V. ROOS, ESQ.
                              PAGE MAILLIARD, ESQ.
                     Wilson Sonsini Goodrich & Rosati, P.C.
                               650 Page Mill Road
                        Palo Alto, California 94304-1050
                  DATE OF COMMENCEMENT OF SALE TO THE PUBLIC:
                                 March 13, 1996
                            ------------------------
 
    If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. / /
 
    If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective statement for the same
offering. / /
 
    If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box. / /
 
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- --------------------------------------------------------------------------------
<PAGE>
                        CALCULATION OF REGISTRATION FEE
 
   
<TABLE>
<CAPTION>
                                                                   PROPOSED MAXIMUM
            TITLE OF EACH CLASS                     AMOUNT            PRICE PER        PROPOSED MAXIMUM       AMOUNT OF
          OF SECURITIES REGISTERED                REGISTERED         SECURITY(1)        OFFERING PRICE     REGISTRATION FEE
<S>                                           <C>                 <C>                 <C>                 <C>
Common Stock, $.001 par value (2)(3)........      4,025,000             $7.50            $30,187,500              --
Common Stock Purchase Warrants ("Warrants")
 (2)(4).....................................      4,025,000              0.00                 0                   --
Common Stock issuable upon exercise of
 Warrants (5)(6)............................      4,025,000             11.25             45,281,250              --
Representative's Warrant (7)(8).............          1                  5.00                 5                   --
Common Stock issuable upon exercise of
 Representative's Warrant (8)(9)............       350,000               9.00             3,150,000               --
Warrants issuable upon exercise of
 Representative's Warrant (8)(9)............       350,000               0.00                 0                   --
Common Stock underlying Warrants issuable
 upon exercise of Representative's Warrant
 (6)(9).....................................       350,000              11.25             3,937,500               --
Totals......................................          --                  --              82,556,250         $28,468(10)
</TABLE>
    
 
(1) Estimated solely for the purpose of computing the amount of the registration
    fee pursuant to Rule 457.
 
(2) The Common Stock and Warrants were registered as component parts of a Unit.
    On March 13, 1996, a total of 4,025,000 Units were registered, each Unit
    consisting of one share of Common Stock and one Warrant. For the purposes of
    calculation of the registration fee, each share of Common Stock sold as a
    component part of the Units had been assumed to have a proposed maximum
    offering price per share of $7.50, and each Warrant was assumed to have a
    proposed maximum offering price per Warrant of $0.00.
 
(3) Includes 525,000 shares included in the 525,000 Units that the underwriters
    for the Company's initial public offering (the "Underwriters") were to
    purchase to cover over-allotments in connection with the Registrant's sale
    of the Units.
 
(4) Includes 525,000 Warrants included in the 525,000 Units that the
    Underwriters were to purchase to cover over-allotments in connection with
    the Registrant's sale of the Units.
 
(5) Includes 525,000 shares issuable upon exercise of Warrants included in the
    525,000 Units that the Underwriters were to purchase to cover
    over-allotments in connection with the Registrant's sale of the Units. Such
    shares were registered for resale by the Purchasers thereof and their
    assigns and transferees on a delayed or continuous basis pursuant to Rule
    415 under the Securities Act of 1933.
 
(6) An indeterminate number of additional shares of Common Stock were
    registered, as provided in the Warrants and the Representative's Warrant, in
    the event provisions against dilution therein become operative.
 
(7) In connection with the Registrant's sale of the Units, the Registrant
    granted to the Representative of the several Underwriters (the
    "Representative") a warrant to purchase 350,000 Units (the "Representative's
    Warrant"). The price paid by the Representative for the Representative's
    Warrant was $5.
 
(8) The exercise price of the Representative's Warrant was expected to be $9.00
    per Unit, based upon an assumed maximum initial public offering price of
    $7.50. For purposes of calculation of the registration fee, each share of
    Common Stock included in a Unit issuable upon exercise of the
    Representative's Warrant had been assumed to have a proposed maximum
    offering price of $9.00, and each Warrant included in a Unit issuable upon
    exercise of the Representative's Warrant had been assumed to have a proposed
    maximum offering price of $0.00.
 
(9) Such shares and Warrants were registered for resale by the Representative
    and its assigns and transferees on a delayed or continuous basis pursuant to
    Rule 415 under the Securities Act of 1933.
 
   
(10) The fee paid pursuant to this Post-Effective Amendment No. 3 is $0: A total
    of $28,468 was previously paid.
    
<PAGE>
   
                                EXPLANATORY NOTE
    
 
   
    This Post-Effective Amendment No. 3 (the "Amendment") on Form S-3 to the
Registration Statement on Form SB-2 (the "Registration Statement") is being
filed pursuant to Rule 414 under the Securities Act of 1933, as amended (the
"1933 Act") by SuperGen, Inc., a Delaware corporation ("SuperGen Delaware" or
the "Registrant"), which is the successor to SuperGen, Inc., a California
corporation ("SuperGen California"), following a statutory merger effective on
November 3, 1997 (the "Merger") for the purpose of changing SuperGen
California's state of incorporation. Prior to the Merger, SuperGen Delaware had
no assets or liabilities other than nominal assets or liabilities. In connection
with the Merger, SuperGen Delaware succeeded by operation of law to all of the
assets and liabilities of SuperGen California. The Merger was approved by the
shareholders of SuperGen California at a meeting for which proxies were
solicited pursuant to Section 14(a) of the Securities Exchange Act of 1934, as
amended (the "1934 Act").
    
 
   
    Except as modified by this Amendment, SuperGen Delaware, by virtue of this
Amendment, expressly adopts the Registration Statement as its own registration
statement for all purposes of the 1933 Act and the 1934 Act.
    
<PAGE>
                                4,724,302 SHARES
 
                                     [LOGO]
 
                                  COMMON STOCK
 
    This Prospectus relates to 4,024,302 shares of SuperGen, Inc.'s ("SuperGen"
or the "Company") common stock, $.001 par value (the "Common Stock") issuable
upon the exercise of 4,024,302 warrants (the "Warrants") issued in connection
with the Company's initial public offering (the "Initial Offering"). As part of
the Initial Offering, 3,500,000 units (the "Units") were issued on March 13,
1996 and 524,302 Units were issued on April 11, 1996 upon exercise of the
underwriter's overallotment option (the "Initial Offering"). Each Unit consisted
of one share of the Common Stock and one Warrant. The Units separated
immediately upon issuance, and the Common Stock and Warrants that made up the
Units trade only as separate securities. Each Warrant entitles the holder
thereof to purchase one share of Common Stock at a price of $9.00 per share,
subject to adjustment under certain circumstances. The Warrants are exercisable
at any time, unless previously redeemed, until March 13, 2001, subject to
certain conditions. The Company may redeem the Warrants, in whole or in part, at
any time upon at least thirty days prior written notice to the registered
holders thereof, at a price of $.25 per Warrant, provided that the closing bid
price of the Common Stock has exceeded $18.00 for the 20 consecutive trading
days immediately preceding the date of the notice of redemption.
 
    In addition, this Prospectus relates to 350,000 shares of Common Stock and
350,000 Warrants issuable upon the exercise of a warrant (the "Representative's
Warrant") issued to Paulson Investment Company Inc. (the "Representative"), as
representative of the several underwriters in the Initial Offering, as well as
the 350,000 shares of Common Stock issuable upon exercise of the Warrants
included in the Representative's Warrant. The exercise price of the
Representative's Warrant is $7.20 per Unit and the Representative's Warrant is
exercisable at any time until March 13, 2001.
 
    The exercise price of the Warrants and the Representative's Warrant was
determined by negotiations between the Company and the Representative in
connection with the Initial Offering. Among the factors considered in
determining the exercise price of the Warrants at the Initial Offering were the
history and the prospects of the Company at the time of the Initial Offering and
the industry in which it operated at such time, the status and development
prospects for the Company's proposed products at such time and the trends of
such results, the experience and qualifications of the Company's executive
officers at such time and the general condition of the securities markets as of
such time. The Company will receive proceeds from the exercise of the Warrants,
the Representative's Warrant and the Warrants issuable upon exercise of the
Representative's Warrant (collectively, "All Warrants"). See "Description of
Securities--Representative's Warrant" and "Description of Securities--Warrants."
 
    The Common Stock and Warrants commenced trading on the Nasdaq National
Market on March 13, 1996 and are listed on the Nasdaq National Market under the
symbols "SUPG" and "SUPGW," respectively.
 
   
    THE SECURITIES ISSUABLE UPON EXERCISE OF THE WARRANTS AND THE
REPRESENTATIVE'S WARRANT INVOLVE A HIGH DEGREE OF RISK. SEE "RISK FACTORS"
BEGINNING AT PAGE 4.
    
                             ---------------------
 THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES AND
     EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION NOR HAS THE
     SECURITIES AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION
         PASSED UPON THE ACCURACY OR ADEQUACY OF THIS PROSPECTUS. ANY
            REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.
 
   
<TABLE>
<CAPTION>
                                                                                   UNDERWRITING
                                                                                     DISCOUNTS             PROCEEDS TO
                                                                PRICE             AND COMMISSIONS            COMPANY
<S>                                                     <C>                    <C>                    <C>
Per Share of Common Stock.............................          $(1)                    $--                   $(1)
Total.................................................     $40,837,068(2)            $985,863            $39,851,205(2)
</TABLE>
    
 
(1) The exercise price of the Warrants (including the 350,000 Warrants issuable
    upon exercise of the Representative's Warrant) is $9.00 per share. The
    exercise price for the Representative's Warrant is $7.20 per Unit.
 
   
(2) Before deducting estimated expenses payable by the Company estimated at
    $15,000 and after deducting $907,650 of proceeds received by the Company
    upon exercise of 100,850 Warrants prior to October 30, 1997 and $144,000 of
    proceeds received by the Company upon the partial exercise of the
    Representative's Warrant for 20,000 Units prior to October 30, 1997.
    
 
   
                THE DATE OF THIS PROSPECTUS IS NOVEMBER 5, 1997.
    
<PAGE>
                             AVAILABLE INFORMATION
 
    The Company will furnish without charge to each person, including any
beneficial owner, to whom this Prospectus is delivered, upon written or oral
request, a copy of any and all of the information that has been incorporated by
reference in this Prospectus, other than exhibits to such information, unless
such exhibits are specifically incorporated by reference into the information
that this Prospectus incorporates. Requests should be submitted by telephone to
(510) 327-0200 or in writing to SuperGen, Inc., Two Annabel Lane, Suite 220, San
Ramon, California 94583, Attn: Investor Relations.
 
    The Company is subject to the information requirements of the Securities
Exchange Act of 1934, as amended (the "Exchange Act"), and in accordance
therewith files reports and other information with the Securities and Exchange
Commission (the "Commission"). Such reports, proxy statements and other
information may be inspected and copied at the public reference facilities of
the Commission at Room 1024, Judiciary Plaza, 450 Fifth Street, N.W.,
Washington, D.C. 20549, and at the following regional offices of the Commission:
7 World Trade Center, Suite 1300, New York, New York 10048 and Suite 1400,
Citicorp Center, 500 West Madison Street, Chicago, Illinois 60661. Copies of
such material can be obtained from the Public Reference Section of the
Commission, 450 Fifth Street, N.W., Washington, D.C. 20549, at prescribed rates.
In addition, such material concerning the Company can also be inspected at the
offices of the National Association of Securities Dealers, Inc., 1735 K Street,
N.W. Washington, D.C. 20006. The Commission also maintains a World Wide Web site
(http://www.sec.gov) that contains reports, proxy and information statements and
other information regarding registrants that file electronically with the
Commission.
 
                             ADDITIONAL INFORMATION
 
    This Prospectus constitutes a part of a Registration Statement on Form S-3
filed by the Company with the Commission under the Securities Act of 1993, as
amended (the "Securities Act"). This Prospectus omits certain of the information
contained in the Registration Statement, and reference is hereby made to the
Registration Statement and related exhibits for further information with respect
to the Company and the securities offered hereby. Any statements contained
herein concerning the provisions of any document are not necessarily complete,
and, in such instance, reference is made to the copy of such document filed as
an exhibit to the Registration Statement or otherwise filed with the Commission.
Each such statement is qualified in its entirety by such reference.
 
                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
 
   
    The following documents, filed or to be filed with the Commission
(Commission File No. 0-27628) under the Exchange Act, are hereby incorporated by
reference into this Prospectus: (a) the Company's Annual Report on Form 10-K for
the fiscal year ended December 31, 1996; (b) the Company's Proxy Statement for
the 1997 Annual Meeting of Shareholders, filed pursuant to Section 14 of the
Exchange Act; (c) the Company's Reports on Form 10-Q for the fiscal quarter
ended March 31, 1997 and the fiscal quarter ended June 30, 1997; (d) the
Company's Report on Form 8-K filed with the Commission on July 2, 1997; (e) the
Company's Report on Form 8-K filed with the Commission on October 31, 1997; and
(f) the Company's Report on Form 8-K filed with the Commission on November 3,
1997.
    
 
    Additionally, all documents filed by the Company with the Commission
pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to
the date of this Prospectus and prior to the termination of the offering made
hereby shall be deemed to be incorporated by reference in this Prospectus and to
be a part hereof from the date of filing of such documents. Any statement or
information contained in a document incorporated by reference herein shall be
deemed to be modified or superseded for purposes of this Prospectus to the
extent that a statement of information contained herein modifies or replaces
such a statement or such information filed previously. Any such statement or
information so modified or replaced shall not be deemed, except as so modified
or replaced, to constitute a part of this Prospectus. Such incorporation by
reference shall not be deemed specifically to incorporate by reference the
information referred to in Item 402(a)(8) of Regulation S-K under the Securities
Act.
                            ------------------------
 
    This prospectus includes trademarks and registered trademarks of the Company
and trademarks and registered trademarks of other companies.
                            ------------------------
 
                                       2
<PAGE>
                                  THE COMPANY
 
    SuperGen, Inc. (the "Company" or "SuperGen") is an emerging pharmaceutical
company dedicated to the acquisition, development and commercialization of
products intended to treat life-threatening diseases, particularly cancer and
blood cell (hematological) disorders, and other serious conditions such as
obesity and diabetes. SuperGen is developing its portfolio of anticancer drugs
through the development of its generic, proprietary and Extra-TM- products (its
enhanced line of patented products) and through the acquisition of certain
anticancer products which complement its portfolio and provide the Company with
market opportunities. The Company is currently marketing certain of its acquired
products, including Nipent-Registered Trademark- (Pentostatin), a proprietary
anticancer drug and Etoposide, a generic anticancer drug. The Company is also
developing a group of proprietary blood cell disorder products for the treatment
of anemia associated with chemotherapy, radiotherapy, renal failure and aplastic
anemia. SuperGen's proprietary obesity pill, which has shown promise in early
preclinical and human studies for general obesity, is currently in Phase II
clinical trials. To date, the Company has received Orphan Drug Designations for
its aplastic anemia agent and for its obesity pill in the treatment of a genetic
disorder leading to chronic obesity. The Company has also received a grant from
the U.S. government for aplastic anemia clinical trials.
 
   
    SuperGen was incorporated in March 1991 as a California corporation. The
Company changed its state of incorporation to Delaware on November 3, 1997.
SuperGen's executive offices are located at Two Annabel Lane, Suite 220, San
Ramon, California, and its telephone number at that address is (510) 327-0200.
    
 
                                       3
<PAGE>
                                  RISK FACTORS
 
    IN EVALUATING THE COMPANY AND ITS BUSINESS, PROSPECTIVE INVESTORS SHOULD
CAREFULLY CONSIDER THE FOLLOWING RISKS IN ADDITION TO THE OTHER INFORMATION
CONTAINED ELSEWHERE HEREIN. BECAUSE ANY INVESTMENT IN THE COMPANY'S CAPITAL
STOCK INVOLVES A HIGH DEGREE OF RISK, ONLY INVESTORS WHO CAN ACCOMMODATE SUCH
RISKS, INCLUDING A COMPLETE LOSS OF THEIR INVESTMENT, SHOULD PURCHASE COMMON
STOCK THROUGH THE EXERCISE OF THE WARRANTS.
 
    THE FOLLOWING DISCUSSION AND OTHER PARTS OF THIS PROSPECTUS CONTAIN
FORWARD-LOOKING STATEMENTS WITHIN THE MEANING OF SECTION 27A OF THE SECURITIES
ACT OF 1933, AS AMENDED, AND SECTION 21E OF THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED. THESE FORWARD-LOOKING STATEMENTS REPRESENT THE COMPANY'S
EXPECTATIONS OR BELIEFS CONCERNING FUTURE EVENTS AND INCLUDE STATEMENTS, AMONG
OTHERS, REGARDING THE TIMING AND PROGRESS OF THE DEVELOPMENT OF THE COMPANY'S
PROPOSED PRODUCTS, FILING AND RECEIVING REGULATORY APPROVALS, ACQUIRING
ADDITIONAL PRODUCTS AND TECHNOLOGIES, SOURCING OF BULK GENERICS AND THE
MANUFACTURING OF FINISHED PRODUCTS, ANTICIPATING THE MARKET OPPORTUNITIES FOR
ITS EXTRA-TM- AND PROPRIETARY PRODUCTS, MARKETING CURRENT AND PROPOSED PRODUCTS
TO HOSPITAL BUYING GROUPS AND OTHERS, DEVELOPING DISTRIBUTOR RELATIONSHIPS,
FORMING STRATEGIC MARKETING RELATIONSHIPS, INCURRING OPERATING LOSSES AND
REQUIRING ADDITIONAL CAPITAL, REDUCING INVENTORY LEVELS AND COSTS PER UNIT, AND
INCURRING CAPITAL EXPENDITURES. ACTUAL RESULTS COULD DIFFER MATERIALLY FROM
THOSE PROJECTED IN THE FORWARD-LOOKING STATEMENTS AS A RESULT OF THE FAILURE TO
RECEIVE APPROPRIATE REGULATORY APPROVALS OF MARKETING OR MANUFACTURING
ACTIVITIES ON A TIMELY BASIS, LACK OF MARKET ACCEPTANCE OF AND DEMAND FOR THE
COMPANY'S PRODUCTS, INTENSE PRICE OR PRODUCT COMPETITION, LACK OF AVAILABLE
SUPPLY OF BULK GENERICS, FAILURE TO SELL EXISTING INVENTORIES AT PRICES
SUFFICIENT TO COVER RELATED COSTS, FAILURE TO OBTAIN ADDITIONAL FINANCING AND
OTHER FACTORS SET FORTH BELOW AND ELSEWHERE IN THIS PROSPECTUS.
 
    HISTORY OF OPERATING LOSSES; FUTURE PROFITABILITY UNCERTAIN.  Since its
inception in 1991 through June 30, 1997, the Company has incurred losses of
approximately $30.4 million (including non-cash charges of approximately $4.9
million for the acquisition of in-process research and development),
substantially all of which consisted of research and development and general and
administrative expenses. Although the Company acquired the right to distribute
four products in the third quarter of 1996 and an additional product in the
first quarter of 1997, sales of these products have been minimal to date, and
there can be no assurance that such sales will exceed the related product and
selling expenses due to the intense competition and potential for significant
selling price and gross margin erosion. The Company expects to continue to incur
substantial operating losses. The Company's ability to achieve a profitable
level of operations in the future will depend in large part on its completing
product development and obtaining regulatory approval of its proprietary
(including Extra-TM-) products and bringing several of these products to market.
The likelihood of the long-term success of the Company must be considered in
light of the expenses, difficulties and delays frequently encountered in the
development and commercialization of new pharmaceutical products and
competition, as well as the burdensome regulatory environment in which the
Company operates. There can be no assurance that the Company will ever achieve
significant revenues or profitable operations.
 
    GENERIC AND EXTRA-TM- PHARMACEUTICAL PRODUCT DEVELOPMENT.  The Company's
success is dependent upon the successful commercialization of its potential
generic and Extra-TM- products. However, there can be no assurance that
government approvals will be obtained or, if obtained, that the Company will
successfully commercialize its generic or Extra-TM- products. While the Company
has obtained bulk source approvals
 
                                       4
<PAGE>
from the FDA for certain of its generic and Extra-TM- products, it has yet to
receive marketing approval for any of its internally developed products, and
there can be no assurance that any such marketing approval will be obtained. As
a result, there can be no assurance that any of the Company's potential generic
or Extra-TM- products will ever be brought to market. In the event any of the
Company's generic and Extra-TM- products are brought to market, such products
will face intense competition and the potential for significant price and gross
profit margin erosion.
 
    A significant number of products currently in development by the Company
consist of generic products for which patent protection has expired. Both the
price at which the Company can expect to sell such products and the volume of
any such sales are expected to depend to a significant degree on the number of
competitors at any time. There can be no assurance that the prices or volumes
achieved by the Company for any such products will meet the Company's
expectations that formed the basis for its decision to proceed with development
or will justify production of such products.
 
    EARLY STAGE OF DEVELOPMENT OF PROPRIETARY PRODUCTS; UNCERTAINTY OF FINAL
PRODUCT DEVELOPMENT.  While the Company's proposed proprietary products are in
the development rather than the research stage, significant development remains
prior to the time any of these proposed products may be brought to market. The
Company believes that results obtained to date in its preclinical and pilot
clinical studies support further development of its potential proprietary
products, but are not necessarily indicative of results that will be obtained in
further testing, including controlled human clinical testing. All of the
potential proprietary products currently under development by the Company will
require extensive clinical testing prior to submission of any regulatory
application for commercial use. Such proposed proprietary products as well as
the Company's proposed generic and Extra-TM- products are subject to the risks
of failure inherent in the development of pharmaceutical products, including the
possibilities that some of the Company's potential products will be found to be
unsafe or ineffective or otherwise fail to receive necessary regulatory
clearances; that the products, if safe and effective, will be difficult to
manufacture on a large scale or uneconomical to market; that the proprietary
rights of third parties will preclude the Company from marketing such products;
or that third parties will market superior or equivalent products. As a result,
there can be no assurance that any of the Company's products will be
successfully developed, receive required governmental regulatory approvals,
become commercially viable or achieve market acceptance.
 
    ADDITIONAL FINANCING REQUIREMENTS.  The Company's need for additional
funding is expected to be substantial and will be determined by the progress and
cost of the development and commercialization of its products and other
activities. Based on the Company's current operating plan, additional funds will
be needed after approximately 18 months from the date of this Prospectus.
Moreover, if the Company experiences unanticipated cash requirements during the
interim period, the Company could require additional funds much sooner. The
source, availability and terms of such funding have not been determined.
Although funds may be received from the sale of equity securities or the
exercise of outstanding warrants and options to acquire common stock of the
Company, there is no assurance any such funding will occur. Failure to obtain
adequate financing in a timely manner would have a material adverse effect on
the Company's business, results of operations and cash flows.
 
    NEED TO COMPLY WITH GOVERNMENTAL REGULATION AND TO OBTAIN PRODUCT
APPROVALS.  The research, testing, manufacture, labeling, distribution,
marketing and advertising of products such as the Company's existing and
proposed products and its ongoing research and development activities are
subject to extensive regulation by governmental regulatory authorities in the
U.S. and other countries. The FDA and comparable agencies in foreign countries
impose substantial requirements on the introduction of new pharmaceutical
products through lengthy and detailed clinical testing procedures, sampling
activities and other costly and time consuming compliance procedures. The
Company's generic drugs require approval of the bulk source of the drug and FDA
approval of the final formulation. The Company's proposed Extra-TM- drugs
require the approvals required for a generic drug but will further require
additional preclinical and
 
                                       5
<PAGE>
clinical testing relating to the proposed new formulation of the Extra-TM- drug.
The Company's proprietary nongeneric drugs require substantial clinical trials
and FDA review as new drugs. The Company cannot predict with certainty when it
might submit many of its proprietary nongeneric products currently under
development for regulatory review. Once the Company submits its potential
products for review, there can be no assurance that FDA or other regulatory
approvals for any pharmaceutical products developed by the Company will be
granted on a timely basis or at all. A delay in obtaining or failure to obtain
such approvals would have a material adverse effect on the Company's business,
results of operations and cash flows. Failure to comply with regulatory
requirements could subject the Company to regulatory or judicial enforcement
actions, including, but not limited to, product recalls or seizures,
injunctions, civil penalties, criminal prosecution, refusals to approve new
products and withdrawal of existing approvals, as well as potentially enhanced
product liability exposure. Sales of the Company's products outside the U.S.
will be subject to regulatory requirements governing clinical trials and
marketing approval. These requirements vary widely from country to country and
could delay introduction of the Company's products in those countries.
 
    COMPETITION.  There are many companies, both public and private, including
well-known pharmaceutical companies, that are engaged in the development and
sale of products for certain of the applications being pursued by the Company.
The Company's competitors include Amgen Inc. ("Amgen"), Chiron Corp. ("Chiron"),
Gensia, Inc. ("Gensia"), Bristol-Myers Squibb Company ("Bristol-Myers Squibb")
and Immunex Corp. ("Immunex"), among others. Most of these companies have
substantially greater financial, research and development, manufacturing and
marketing experience and resources than the Company does and represent
substantial long-term competition for the Company. Such companies may succeed in
developing pharmaceutical products that are more effective or less costly than
any that may be developed or marketed by the Company.
 
    Factors affecting competition in the pharmaceutical industry vary depending
on the extent to which the competitor is able to achieve a competitive advantage
based on proprietary technology. If the Company is able to establish and
maintain a significant proprietary position with respect to its proprietary
products, competition will likely depend primarily on the effectiveness of the
product and the number, gravity and severity of its unwanted side effects as
compared to alternative products. Competition with respect to generic products
is based primarily on price and, to a lesser extent, on name recognition and the
reputation of the manufacturer in its target markets. Moreover, the number of
competitors offering a particular generic product can dramatically affect price
and gross margin for that product. The Company may be at a disadvantage in
competing with more established companies on the basis of price or market
reputation. In addition, increased competition in a particular generic market
would likely lead to significant price erosion which would have a negative
effect on the Company's potential gross profit margins. For example, the Company
believes that the total estimated U.S. sales for Mitomycin and Etoposide, as
well as other of the Company's proposed generic products, have decreased
significantly in recent months due to increased competition and that sales for
these generics may continue to decrease in the future as a result of competitive
factors, including the introduction of additional generics as well as other
cancer drugs, new formulations for these drugs and the use of different
therapies.
 
    The industry in which the Company competes is characterized by extensive
research and development efforts and rapid technological progress. Although the
Company believes that its proprietary position may give it a competitive
advantage with respect to its proposed non-generic drugs, new developments are
expected to continue and there can be no assurance that discoveries by others
will not render the Company's current and potential products noncompetitive. The
Company's competitive position also depends on its ability to attract and retain
qualified scientific and other personnel, develop effective proprietary
products, implement development and marketing plans, obtain patent protection
and secure adequate capital resources.
 
    PATENTS AND PROPRIETARY TECHNOLOGY.  The Company actively pursues a policy
of seeking patent protection for its proprietary products and technologies. The
Company has licenses to or assignments of
 
                                       6
<PAGE>
numerous issued U.S. patents. However, there can be no assurance that the
Company's patent position will provide it with significant protection against
competitors. Litigation could be necessary to protect the Company's patent
position, and there can be no assurance that the Company will have the required
resources to pursue such litigation or otherwise to protect its patent rights.
In addition to pursuing patent protection in appropriate cases, the Company also
relies on trade secret protection for its unpatented proprietary technology.
However, trade secrets are difficult to protect. There can be no assurance that
others will not independently develop substantially equivalent proprietary
information and techniques or otherwise gain access to the Company's trade
secrets, that such trade secrets will not be disclosed or that the Company can
effectively protect its rights to unpatented trade secrets.
 
    The Company's rights to its potential proprietary products are dependent
upon compliance with certain licenses and agreements which require, among other
things, certain royalty and other payments, the Company reasonably exploiting
the underlying technology of the applicable patents, as well as compliance with
certain regulatory filings. Failure to comply with such licenses and agreements
could result in loss of the Company's underlying rights to one or more of these
potential products, which would have a material adverse effect on the Company's
business, results of operations and cash flows.
 
    There can be no assurance that claims against the Company will not be raised
in the future based on patents held by others or that, if raised, such claims
will not be successful. Such other persons could bring legal actions against the
Company claiming damages and seeking to enjoin clinical testing, manufacturing
and marketing of the affected product. If any actions are successful, in
addition to any potential liability for damages, the Company could be required
to obtain a license in order to continue to manufacture or market the affected
product. There can be no assurance that the Company would prevail in any such
action or that any license required under any such patent would be made
available on acceptable terms, if at all. There has been, and the Company
believes that there will continue to be, significant litigation in the
pharmaceutical industry regarding patent and other intellectual property rights.
If the Company becomes involved in any litigation, it could consume a
substantial portion of the Company's resources regardless of the outcome of such
litigation.
 
    LIMITED SUPPLY; MANUFACTURING LIMITATIONS.  The Company currently has a
limited supply of the products it is marketing. While the Company is seeking to
enter into manufacturing agreements to provide adequate supplies to meet market
demand, there is no assurance that the Company will be able to replenish its
supplies on a timely basis. Failure to obtain or retain third party
manufacturing capability or obtain necessary FDA approvals would have a material
adverse effect on the Company's revenues, results of operations and cash flows.
 
    The Company currently relies on foreign manufacturers for the production of
certain of its bulk generics and Extra-TM- formulations and on domestic
manufacturers to supply sufficient quantities of compounds to conduct clinical
trials on its proposed proprietary products. If the Company is unable to
contract for or obtain a sufficient supply of its potential pharmaceutical
products on acceptable terms, or such supplies are delayed or contaminated,
there could be significant delays in bringing the Company's proposed generic and
Extra-TM- products to market, as well as delays in the Company's preclinical and
human clinical testing schedule, and delays in submission of products for
regulatory approval and initiation of new development programs, any of which
could have a material adverse effect on the Company's business, results of
operations and cash flows. If the Company should encounter delays or
difficulties in establishing relationships with manufacturers to produce,
package and distribute its finished pharmaceutical products, market introduction
and subsequent sales of such products would be adversely affected. Moreover,
contract manufacturers that the Company may use must adhere to current Good
Manufacturing Practices ("cGMP") regulations enforced by the FDA through its
facilities inspection program. These facilities must pass a pre-approval plant
inspection before the FDA will issue a pre-market approval of the products. If
the Company is unable to obtain or retain third party manufacturing on
commercially acceptable terms or obtain necessary FDA approvals to manufacture
the products currently being sold, it may not be able to commercialize
pharmaceutical products as planned. The Company's dependence upon
 
                                       7
<PAGE>
third parties for the manufacture of pharmaceutical products may adversely
affect the Company's profit margins and its ability to develop and deliver
pharmaceutical products on a timely and competitive basis.
 
    The Company does not currently intend to manufacture any pharmaceutical
products itself, although it may choose to do so in the future. The Company has
no experience in the manufacture of pharmaceutical products in clinical
quantities or for commercial purposes. Should the Company determine to
manufacture products itself, the Company would be subject to the regulatory
requirements described above, would be subject to similar risks regarding delays
or difficulties encountered in manufacturing any such pharmaceutical products
and would require substantial additional capital. In addition, there can be no
assurance that the Company would be able to manufacture any such products
successfully and in a cost-effective manner.
 
    LIMITED EXPERIENCE.  The Company has only limited experience in procuring
products in commercial quantities, selling pharmaceutical products and
negotiating, setting up or maintaining strategic relationships and conducting
clinical trials and other late stage phases of the regulatory approval process.
There can be no assurance that the Company will successfully engage in any of
these activities. In addition, with respect to certain of the Company's proposed
products, such as the Company's obesity pill, the Company may seek to enter into
joint venture, sublicense or other marketing arrangements with another party
that has an established marketing capability. There can be no assurance that the
Company will be able to enter into any such marketing arrangements with third
parties, or that such marketing arrangements would be successful. In addition,
the Company has no current joint venture, strategic partnering or other similar
agreements with more established pharmaceutical companies, and there can be no
assurance that the Company could negotiate any such arrangements, on an
acceptable basis or at all, if it chose to do so. Accordingly, the viability of
the Company's proposed products has not been independently evaluated by any
independent pharmaceutical company.
 
    DEPENDENCE ON KEY PERSONNEL.  The Company's success is dependent on certain
key management and scientific personnel, including Dr. Joseph Rubinfeld, the
loss of whose services could significantly delay the achievement of the
Company's planned development objectives. The Company currently maintains a key
man life insurance policy in the amount of $2.1 million on Dr. Rubinfeld.
Competition for qualified personnel among pharmaceutical companies is intense,
and the loss of key personnel, or the inability to attract and retain the
additional, highly skilled personnel required for the expansion of the Company's
activities could have a material adverse effect on the Company's business,
results of operations and cash flows.
 
    HEALTH CARE REFORM AND POTENTIAL LIMITATIONS ON THIRD-PARTY REIMBURSEMENT
RELATED MATTERS.  The levels of revenues and profitability of pharmaceutical
companies may be affected by the continuing efforts of governmental and
third-party payors to contain or reduce the costs of health care through various
means. The Company cannot predict the effect health care reforms may have on its
business, and there can be no assurance that any such reforms will not have a
material adverse effect on the Company. In addition, in both the U.S. and
elsewhere, sales of prescription pharmaceuticals are dependent in part on the
availability of reimbursement to the consumer from third-party payors, such as
government and private insurance plans. Third-party payors are increasingly
challenging the prices charged for medical products and services. There can be
no assurance that the Company's current and proposed products will be considered
cost effective and that reimbursement to the consumer will be available or will
be sufficient to allow the Company to sell its products on a competitive basis.
 
    RISK OF PRODUCT LIABILITY.  Clinical trials or marketing of any of the
Company's current and potential pharmaceutical products may expose the Company
to liability claims from the use of such pharmaceutical products. The Company
currently carries product liability insurance; however, there can be no
assurance that the Company will be able to maintain insurance on acceptable
terms for its clinical and commercial activities or that such insurance would be
sufficient to cover any potential product liability claim or recall. Failure to
have sufficient insurance coverage could have a material adverse effect on the
Company's business, results of operations and cash flows.
 
                                       8
<PAGE>
    HAZARDOUS MATERIALS; ENVIRONMENTAL MATTERS.  The Company is subject to
federal, state and local laws and regulations governing the use, manufacture,
storage, handling and disposal of hazardous materials and certain waste
products. The Company currently maintains a supply of several hazardous
materials at the Company's facilities. While the Company outsources its research
and development programs involving the controlled use of biohazardous materials,
if in the future the Company conducts such programs itself, there can be no
assurance that the Company would not be required to incur significant cost to
comply with environmental laws and regulations. In the event of an accident, the
Company could be held liable for any damages that result, and such liability
could exceed the resources of the Company.
 
   
    ANTI-TAKEOVER EFFECTS OF CERTAIN CHARTER PROVISIONS.  Certain provisions of
the Company's Certificate of Incorporation and Bylaws could discourage potential
acquisition proposals, could delay or prevent a change in control of the Company
and could make removal of management more difficult. Such provisions could
diminish the opportunities for a stockholder to participate in tender offers,
including tender offers that are priced above the then-current market value of
the Common Stock. The provisions may also inhibit increases in the market price
of the Common Stock and Warrants that could result from takeover attempts. For
example, the Board of Directors of the Company, without further stockholder
approval, may issue up to 2,000,000 shares of Preferred Stock, in one or more
series, with such terms as the Board of Directors may determine, including
rights such as voting, dividend and conversion rights which could adversely
affect the voting power and other rights of the holders of Common Stock.
Preferred Stock thus may be issued quickly with terms calculated to delay or
prevent a change in control of the Company or make removal of management more
difficult. Additionally, the issuance of Preferred Stock may have the effect of
decreasing the market price of the Common Stock. The Company's Certificate of
Incorporation and Bylaws also provide that stockholder action can be taken only
at an annual or special meeting of stockholders and may not be taken by written
consent. In addition, Section 203 of the Delaware General Corporation Law, which
could have the effect of delaying, deferring or preventing a change of control,
applies. See "Description of Capital Stock."
    
 
   
    CONTROL BY EXISTING STOCKHOLDERS.  The Company's officers, directors and
five-percent stockholders and their affiliates beneficially own approximately
58% of the Company's outstanding shares of Common Stock. Accordingly, these
stockholders, if they were to act as a group, may be able to elect all of the
Company's directors, and otherwise control matters requiring approval by the
stockholders of the Company, including approval of significant corporate
transactions. Such concentration of ownership and the lack of cumulative voting
may also have the effect of delaying or preventing a change in control of the
Company.
    
 
    POSSIBLE VOLATILITY OF COMMON STOCK PRICE.  The trading prices of the
Company's Common Stock and Warrants are subject to significant fluctuations in
response to such factors as, among others, variations in the Company's
anticipated or actual results of operations, announcements of new products or
technological innovations by the Company or its competitors and changes in
earnings estimates by analysts. Moreover, the stock market has from time to time
experienced extreme price and volume fluctuations which have particularly
affected the market prices for emerging growth companies and which have often
been unrelated to the operating performance of such companies. These broad
market fluctuations may adversely affect the market price of the Company's
Common Stock and Warrants. In the past, following periods of volatility in the
market price of a company's common stock, securities class action litigations
have occurred against the issuing company. There can be no assurance that such
litigation will not occur in the future with respect to the Company. Such
litigation could result in substantial costs and a diversion of management's
attention and resources, which could have a material adverse effect on the
Company's business, results of operations and cash flows. Any adverse
determination in such litigation could also subject the Company to significant
liabilities.
 
    CONTINGENT ISSUANCE OF ADDITIONAL SHARES.  The Company has outstanding the
Warrants, the Representative's Warrant and the Warrants underlying the
Representative's Warrant which, if exercised, would
 
                                       9
<PAGE>
   
result in the issuance of 4,603,452 shares of Common Stock. The price which the
Company may receive for the Common Stock issued upon exercise of such warrants
may be less than the market price of the Common Stock at the time of such
exercise. For the life of such warrants the holders are given the opportunity to
profit from a rise in the market price for the Common Stock. So long as such
warrants are not exercised, the terms under which the Company could obtain
additional equity may be adversely affected. Moreover, the holders of such
warrants might be expected to exercise them at a time when the Company would, in
all likelihood, be able to obtain any needed capital by a new offering of its
securities on terms more favorable than those provided for by such warrants. In
addition, should all or substantially all of these warrants be exercised, the
resulting increase in the amount of the Company's Common Stock in the trading
market may adversely affect the market price of the Common Stock.
    
 
    REDEMPTION OF WARRANTS.  The Warrants are subject to redemption at $0.25 per
Warrant on 30 days written notice provided that the closing bid price of the
Common Stock for the 20 consecutive trading days immediately preceding the date
of the notice of redemption exceeds $18.00. In the event the Company exercises
the right to redeem the Warrants, a holder would be forced either to exercise
the Warrant or accept the redemption price. See "Description of
Securities--Warrants."
 
    CURRENT PROSPECTUS AND STATE BLUE SKY REGISTRATION REQUIRED TO EXERCISE THE
WARRANTS.  Holders of Warrants and the Representative's Warrant will be able to
exercise such warrants only if a current prospectus relating to the Common Stock
underlying such warrants is then in effect, and only if such Common Stock is
qualified for sale or exempt from qualification under applicable state
securities law of the state in which such holders of such Warrants reside.
 
    The Warrants are separately transferable. Although the Units were not
knowingly sold to purchasers in jurisdictions in which the Units are not
registered or otherwise qualified for sale, purchasers may buy Warrants in the
after market in, or may move to, jurisdictions in which the shares underlying
the Warrants are not so registered or qualified during the period that the
Warrants are exercisable. In this event, the Company would be unable to issue
shares to those persons desiring to exercise their Warrants, and holders of
Warrants would have no choice but to attempt to sell the Warrants in a
jurisdiction where such sale is permissible or allow them to expire unexercised.
See "Description of Securities--Warrants."
 
                                USE OF PROCEEDS
 
   
    In the event that all Warrants are exercised, of which there is no
assurance, the Company could realize up to $39,851,205(1), before deducting the
estimated expenses related to this Prospectus. Such proceeds will be considered
uncommitted funds and may be used by the Company as working capital and general
corporate purposes, including research and development and marketing and sales
for products the Company is currently marketing and products which the Company
may develop.
    
 
    The Company believes that the existing cash and cash equivalents will
satisfy its budgeted cash requirements for the 18 months from the date of this
Prospectus, based upon the Company's current operating plan. The Company's
current operating plan shows that at the end of such 18 month period, the
Company will require substantial additional capital. See "Risk
Factors--Additional Financing Requirements."
 
                                DIVIDEND POLICY
 
    The Company has not declared or paid cash dividends on its Common Stock. The
Company currently intends to retain all future earnings to fund the operation of
its business and, therefore, does not anticipate
 
- ------------------------
 
   
(1) After deducting $907,650 received by the Company from 100,850 Warrants
    exercised prior to October 30, 1997 and $144,000 of proceeds received by the
    Company upon the partial exercise of the Representative's Warrant for 20,000
    Units prior to October 30, 1997.
    
 
                                       10
<PAGE>
paying dividends in the foreseeable future. Future cash dividends, if any, will
be determined by the Board of Directors.
 
                              PLAN OF DISTRIBUTION
 
    The Warrants and the Common Stock issuable upon exercise of the Warrants may
be sold from time to time by the holders thereof or by pledgees, donees,
transferees or other successors in interest. Such sales may be made in any one
or more transactions (which may involve block transactions) on The Nasdaq Stock
Market, or any exchange on which the Warrants and the Common Stock may then be
listed, in the over-the-counter market or otherwise in negotiated transactions
or a combination of such methods of sale, at market prices prevailing at the
time of sale, at prices related to such prevailing market prices or at
negotiated prices. The holders of the Warrants and the Common Stock that is
issuable upon exercise of the Warrants may effect such transactions by selling
Warrants or shares to or through broker-dealers, and such broker-dealers may
sell the Warrants and the Common Stock issuable upon exercise of the Warrants as
agent or may purchase such Warrants or shares of Common Stock as principal and
resell them for their own account pursuant to this Prospectus. Such
broker-dealers may receive compensation in the form of underwriting discounts,
concessions or commissions from the holders and/or purchasers the Warrants and
the Common Stock that is issuable upon exercise of the Warrants, for whom they
may act as agent (which compensation may be in excess of customary commissions).
In connection with such sales, the holders and any participating brokers or
dealers may be deemed to be "underwriters" as defined in the Securities Act.
 
    From time to time, the Company intends to retain brokers and agents to
solicit the holders of Warrants to exercise their Warrants. The Company intends
to pay such brokers and agents a solicitation fee equal to $.25 per share of
Common Stock issued upon exercise of Warrants by holders solicited by such
brokers and agents. In addition, the Company has agreed that if it elects to
redeem the Warrants, it will retain the Representative as the Company's
solicitation agent ("Warrant Solicitation Agent"). The Company has agreed to pay
the Warrant Solicitation Agent for its services a solicitation fee equal to 2%
of the total amount paid by the holders of the Warrants whom the Warrant
Solicitation Agent solicited to exercise the Warrants. Any exercise will be
presumed to be unsolicited unless the customer states in writing that the
transaction was solicited by a broker or agent or the Warrant Solicitation
Agent, as the case may be, and designates in writing the registered
representative as the broker or agent or Warrant Solicitation Agent, as the case
may be, entitled to receive compensation for the exercise. The fee is not
payable for the exercise of any Warrant held by a broker or agent or the Warrant
Solicitation Agent, as the case may be, in a discretionary account at the time
of exercise, unless a broker or agent or the Warrant Solicitation Agent, as the
case may be, receives from the customer prior specific written approval of such
exercise.
 
                                       11
<PAGE>
                           DESCRIPTION OF SECURITIES
 
   
    The authorized capital stock of the Company consists of 40,000,000 shares of
Common Stock and 2,000,000 shares of Preferred Stock.
    
 
COMMON STOCK
 
   
    The Company's authorized common stock consists of 40,000,000 shares of
Common Stock. As of October 30, 1997, there were issued and outstanding
19,216,371 shares of Common Stock of the Company. The holders of Common Stock
are entitled to one vote for each share held of record on all matters submitted
to a vote of stockholders. Subject to preferences that may be applicable to
outstanding shares of Preferred Stock, if any, the holders of Common Stock are
entitled to receive ratably such dividends as may be declared by the Company's
Board of Directors out of funds legally available therefor. Holders of Common
Stock have no preemptive, subscription or redemption rights, and there are no
redemption, conversion or similar rights with respect to such shares. The
outstanding shares of Common Stock are fully paid and nonassessable. The
Company's Certificate of Incorporation does not provide for cumulative voting
rights.
    
 
PREFERRED STOCK
 
   
    The Company is authorized to issue up to 2,000,000 shares of undesignated
Preferred Stock. The Board of Directors has the authority to issue the
undesignated Preferred Stock in one or more series and to fix the rights,
preferences, privileges and restrictions granted to or imposed upon any wholly
unissued shares of undesignated Preferred Stock, as well as to fix the number of
shares constituting any series and the designation of such series, without any
further vote or action by the shareholders. The Board of Directors, without
stockholder approval, may issue Preferred Stock with voting and conversion
rights which could materially adversely affect the voting power of the holders
of Common Stock. The issuance of Preferred Stock could also decrease the amount
of earnings and assets available for distribution to holders of Common Stock. In
addition, the issuance of Preferred Stock may have the effect of delaying,
deferring or preventing a change in control of the Company. At present, the
Company has no plans to issue any shares of Preferred Stock. See "Risk
Factors--Anti-Takeover Effects of Certain Charter Provisions."
    
 
WARRANTS
 
REPRESENTATIVE'S WARRANT
 
    The Company has issued the Representative's Warrant and has reserved 680,000
shares of Common Stock for issuance upon exercise of the outstanding portion of
such warrant (including the Warrants issuable upon exercise of the
Representative's Warrant). The Representative's Warrant will entitle the holder
to acquire 330,000 Units at an exercise price of $7.20 per Unit. The
Representative's Warrant will be exercisable at any time until March 13, 2001.
 
THE WARRANTS
 
    Each Warrant entitles the holder to purchase one share of Common Stock at a
price of $9.00 per share. The Warrants, subject to certain conditions, are
exercisable at any time until March 13, 2001, unless earlier redeemed. The
Warrants are redeemable by the Company, at $.25 per Warrant, upon thirty (30)
days written notice, if the closing bid price (as defined in the Warrant
Agreement described below) per share of the Common Stock for the twenty (20)
consecutive trading days immediately preceding the date notice of redemption is
given exceeds $18.00. If the Company gives notice of its intention to redeem, a
holder would be forced either to exercise his or her Warrant before the date
specified in the redemption notice or accept the redemption price.
 
                                       12
<PAGE>
    The Warrants were issued in registered form under a Warrant Agreement (the
"Warrant Agreement") between the Company and ChaseMellon Shareholder Services,
L.L.C. (formerly First Interstate Bank of California), as warrant agent (the
"Warrant Agent"). The shares of Common Stock underlying the Warrants, when
issued upon exercise of a Warrant, will be fully paid and nonassessable, and the
Company will pay any transfer tax incurred as a result of the issuance of Common
Stock to the holder upon its exercise.
 
   
    The Warrants and the Representative's Warrant contain provisions that
protect the holders against dilution by adjustment of the exercise price. Such
adjustments will occur in the event, among others, that the Company makes
certain distributions to holders of its Common Stock. The Company is not
required to issue fractional shares upon the exercise of a Warrant or
Representative's Warrant. The holder of a Warrant or Representative's Warrant
will not possess any rights as a stockholder of the Company until such holder
exercises the Warrant or Representative's Warrant.
    
 
    A Warrant may be exercised upon surrender of the Warrant Certificate on or
before the expiration date of the Warrant at the offices of the Warrant Agent,
with the form of "Election To Purchase" on the reverse side of the Warrant
Certificate completed and executed as indicated, accompanied by payment of the
exercise price (by certified or bank check payable to the order of the Company)
for the number of shares with respect to which the Warrant is being exercised.
 
    For a holder to exercise the Warrants, there must be a current registration
statement in effect with the Commission and qualification in effect under
applicable state securities laws (or applicable exemptions from state
qualification requirements) with respect to the issuance of shares or other
securities underlying the Warrants. The Company has agreed to use all
commercially reasonable efforts to cause a registration statement with respect
to such securities under the Securities Act to be filed and to become and remain
effective in anticipation of and prior to the exercise of the Warrants and to
take such other actions under the laws of various states as may be required to
cause the sale of Common Stock (or other securities) upon exercise of Warrants
to be lawful. If a current registration statement is not in effect at the time a
Warrant is exercised, the Company may at its option redeem the Warrant by paying
to the holder cash equal to the difference between the market price of the
Common Stock on the exercise date and the exercise price of the Warrant. The
Company will not be required to honor the exercise of Warrants if, in the
opinion of the Company's Board of Directors upon advice of counsel, the sale of
securities upon exercise would be unlawful.
 
    The foregoing discussion of certain terms and provisions of the Warrants and
Representative's Warrant is qualified in its entirety by reference to the
detailed provisions of the Warrant Agreement and Representative's Warrant
Certificate, the form of each of which has been filed as an exhibit to the
Registration Statement of which this Prospectus is a part.
 
    For the life of the Warrants and Representative's Warrant, the holders
thereof have the opportunity to profit from a rise in the market price of the
Common Stock without assuming the risk of ownership of the shares of Common
Stock issuable upon the exercise of the warrants. The warrant holders may be
expected to exercise their warrants at a time when the Company would, in all
likelihood, be able to obtain any needed capital by an offering of Common Stock
on terms more favorable than those provided for by the warrants. Further, the
terms on which the Company could obtain additional capital during the life of
the Warrants may be adversely affected. See "Risk Factors--Additional Financing
Requirements."
 
   
OTHER WARRANTS AND OPTIONS
    
 
   
    The Company has issued and outstanding warrants to acquire up to 174,736
shares of Common Stock to various purchasers at an exercise price of $5.00 per
share of Common Stock subject to the warrant. The warrants expire at varying
dates through February 2001. The Company may redeem the warrants, at any time
upon at least thirty (30) days prior written notice by the Company to the
purchasers, at a price of $.25 per share of Common Stock subject to the warrant,
provided that the average closing price of the
    
 
                                       13
<PAGE>
   
Company's Common Stock for the 10 consecutive trading days immediately preceding
the date notice of redemption is given equals or exceeds $10.00 per share. Also,
the Company has issued and has outstanding an option to purchase up to 850,000
shares of Common Stock (the "Option") at an exercise price of $9.00 per share of
Common Stock subject to the Option. The Option expires on January 31, 1998. In
the same transaction in which the Option was issued, the Company also issued
warrants to acquire up to 850,000 shares of Common Stock to the purchaser of the
Option. In the event such purchaser exercises the Option, the Company will issue
additional warrants to acquire up to 1/2 of the number of shares of Common Stock
issued upon exercise of the Option. The warrants may be exercised at an exercise
price of $13.50 per share of Common Stock and will be subject to the warrants.
The warrants expire in June 2007.
    
 
CERTAIN FEDERAL INCOME TAX CONSIDERATIONS
 
    The following discussion sets forth certain federal income tax consequences,
under current law, relating to the exercise of the Representative's Warrant and
the Warrants. The discussion is a summary and does not purport to deal with all
aspects of federal taxation that may be applicable to an investor, nor does it
consider specific facts and circumstances that may be relevant to a particular
investor's tax position. Certain holders (such as dealers in securities,
insurance companies, tax exempt organizations, foreign persons and those holding
Common Stock or Warrants as part of a straddle or hedge transaction) may be
subject to special rules that are not addressed in this discussion. This
discussion is based on current provisions of the Internal Revenue Code of 1986,
as amended, and on administrative and judicial interpretations as of the date
hereof, all of which are subject to change. ALL INVESTORS SHOULD CONSULT THEIR
OWN TAX ADVISORS AS TO THE SPECIFIC TAX CONSEQUENCES TO THEM OF THIS OFFERING,
INCLUDING THE APPLICABILITY OF FEDERAL, STATE, LOCAL AND FOREIGN TAX LAWS.
 
ALLOCATION OF PURCHASE PRICE
 
    Each Unit as a whole had a tax basis equal to the cost of the Unit. The
measure of income or loss from certain transactions described below depends upon
the tax basis in each of the Warrants and the Common Stock comprising the Unit.
The tax basis for each of the Warrants and the Common Stock was determined by
allocating the cost of the Unit among the securities which comprised the
component parts of the Unit in proportion to the relative fair market values of
those elements at the time of acquisition.
 
EXERCISE AND SALE OF WARRANTS
 
    No gain or loss will be recognized by a holder of a Warrant on the purchase
of shares of Common Stock for cash pursuant to an exercise of a Warrant (except
that gain will be recognized to the extent cash is received in lieu of
fractional shares). The tax basis of Common Stock received upon exercise of a
Warrant will equal the sum of the holder's tax basis for the exercised Warrant
and the exercise price. The holding period of the Common Stock acquired upon the
exercise of the Warrant will begin on the date the Warrant is exercised and the
Common Stock is purchased (i.e., it does not include the period during which the
Warrant was held).
 
    Gain or loss from the sale or other disposition of a Warrant (or loss in the
event the Warrant expires unexercised as discussed below) will be capital gain
or loss to its holder if the Common Stock to which the Warrant relates would
have been a capital asset in the hands of such holder. Such capital gain or loss
will be long-term capital gain or loss if the holder has held the Warrant for
more than one year at the time of the sale, disposition or lapse. On August 5,
1997, legislation was enacted which reduces to 20%, in the case of an
individual, the rate of tax on long-term capital gains on property held for more
than 18 months. Gain on capital assets held between 12 months and 18 months is
subject to tax at a maximum rate of 28%.
 
                                       14
<PAGE>
SALE OF COMMON STOCK
 
    The sale of Common Stock should generally result in the recognition of gain
or loss to the holder thereof in an amount equal to the difference between the
amount realized and such holder's tax basis in the Common Stock. If the Common
Stock constitutes a capital asset in the hands of the holder, gain or loss upon
the sale of the Common Stock will be characterized as long-term or short-term
capital gain or loss, depending on whether the Common Stock has been held for
more than one year. The rate of tax is reduced to 20%, in the case of an
individual, on property held as a capital asset for more than 18 months. Gain on
capital assets held between 12 months and 18 months is subject to tax at a
maximum rate of 28%.
 
EXPIRATION OF WARRANTS WITHOUT EXERCISE
 
    If a holder of a Warrant allows it to expire without exercise, the
expiration will be treated as a sale or exchange of the Warrant on the
expiration date. The holder will have a taxable loss equal to the amount of such
holder's tax basis in the lapsed Warrant. If the Warrant constitutes a capital
asset in the hands of the holder, such taxable loss will be characterized as
long-term or short-term capital loss depending upon whether the Warrant was held
for more than one year.
 
   
CERTAIN PROVISIONS OF THE COMPANY'S CERTIFICATE OF INCORPORATION AND BYLAWS
    
 
   
    Certain provisions of law, and the Company's current Certificate of
Incorporation and Bylaws, could make more difficult the acquisition of the
Company by means of a tender offer, a proxy contest or otherwise and the removal
of incumbent officers and directors. These provisions include: (i) authorization
of the issuance of up to 2,000,000 shares of Preferred Stock, with such
characteristics, and potential effects on the acquisition of the Company, as are
described in "Preferred Stock" above; (ii) elimination of cumulative voting; and
(iii) elimination of stockholder action by written consent. The Bylaws establish
procedures, including advance notice procedures, with regard to nomination,
other than by or at the direction of the Board of Directors, of candidates for
election as directors or for stockholder proposals to be submitted at
stockholder meetings. The Company is also subject to Section 203 of the Delaware
General Corporation Law, an anti-takeover law. In general, Section 203 of the
Delaware General Corporation Law prevents a person owning 15% or more of a
corporation's outstanding voting stock ("Interested Stockholder") from engaging
in a "business combination" (as defined in the Delaware General Corporation Law)
with a Delaware corporation for three years following the date such person
become an Interested Stockholder, subject to certain exceptions such as the
approval of the board of directors and of the holders of at least two-thirds of
the outstanding shares of voting stock not owned by the interested stockholder.
These provisions are expected to discourage certain types of coercive takeover
practices and inadequate takeover bids and to encourage persons seeking to
acquire control of the Company to negotiate first with the Company. The Company
believes that the benefits of increased protection of the Company's potential
ability to negotiate with the proponent of an unfriendly or unsolicited proposal
to acquire or restructure the Company outweigh the disadvantages of discouraging
such proposals because, among other things, negotiation of such proposals could
result in an improvement of their terms. See "Risk Factors--Anti-Takeover
Effects of Certain Charter Provisions."
    
 
TRANSFER AGENT AND REGISTRAR
 
    The Transfer Agent and Registrar for the Company's securities is ChaseMellon
Shareholder Services, L.L.C.
 
                                       15
<PAGE>
                   INDEMNIFICATION OF DIRECTORS AND OFFICERS
 
   
    The Company has adopted provisions in its current Certificate of
Incorporation which (i) eliminate the personal liability of its directors to the
Company for monetary damages to the fullest extent permissible under Delaware
law; and (ii) authorize the Company to indemnify its directors and officers to
the fullest extent permitted by law. Such limitation of liability does not
affect the availability of equitable remedies, such as injunctive relief or
rescission. The Company's Certificate of Incorporation also includes a provision
eliminating to the fullest extent permitted by Delaware law, the personal
liability of its directors for monetary damages for breach of fiduciary duty as
a director. In addition, the Bylaws of the Company provide that it will be
required to indemnify its officers and directors to the maximum extent and in
the manner permitted by the Delaware General Corporation Law.
    
 
   
    The Company has entered into separate indemnification agreements with each
its officers, directors and key employees that contain provisions which are in
some respects broader than the specific indemnification provisions contained in
the Delaware General Corporation Law. The indemnification agreements may require
the Company, among other things, to indemnify such officers and directors
against certain liabilities that may arise by reason of their status or service
as directors of officers (other than liabilities arising from willful misconduct
of a culpable nature), to advance their expenses incurred as a result of any
proceeding against them, as to which they could be indemnified, and to obtain
director's and officer's insurance, if available on reasonable terms. Insofar as
indemnification for liabilities arising under the Securities Act of 1933 (the
"Securities Act") may be permitted to directors, officers and controlling
persons of the Registrant pursuant to the foregoing provisions, or otherwise,
the Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable.
    
 
    At present, the Company is not aware of any pending litigation involving a
director, officer, employee or agent of the Company where indemnification will
be required or permitted. The Company is not aware of any threatened litigation
or proceeding which may result in a claim for such indemnification.
 
                                 LEGAL MATTERS
 
    The validity of the issuance of Common Stock upon exercise of the
Representative's Warrant, the Warrants issuable upon exercise of the
Representative's Warrant and the outstanding Warrants will be passed upon for
the Company by Wilson Sonsini Goodrich & Rosati, P.C., Palo Alto, California.
 
                                    EXPERTS
 
    The consolidated financial statements and schedule of SuperGen, Inc.
included in SuperGen, Inc.'s Annual Report (Form 10-K) for the year ended
December 31, 1996, have been audited by Ernst & Young LLP, independent auditors,
as set forth in their report thereon included therein and incorporated herein by
reference. Such consolidated financial statements and schedule are incorporated
herein by reference in reliance upon such report given upon the authority of
such firm as experts in accounting and auditing.
 
                                       16
<PAGE>
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
    NO DEALER, SALESPERSON OR OTHER PERSON HAS BEEN AUTHORIZED TO GIVE ANY
INFORMATION OR TO MAKE ANY REPRESENTATIONS NOT CONTAINED IN THIS PROSPECTUS IN
CONNECTION WITH THE OFFERING COVERED BY THIS PROSPECTUS. IF GIVEN OR MADE, SUCH
INFORMATION OR REPRESENTATIONS MUST NOT BE RELIED UPON AS HAVING BEEN AUTHORIZED
BY THE COMPANY. THIS PROSPECTUS DOES NOT CONSTITUTE AN OFFER TO SELL, OR A
SOLICITATION OF AN OFFER TO BUY, COMMON STOCK OR WARRANTS IN ANY JURISDICTION TO
ANY PERSON TO WHOM IT IS UNLAWFUL TO MAKE SUCH AN OFFER OR SOLICITATION IN SUCH
JURISDICTION. SUBJECT TO ANY DUTIES AND OBLIGATIONS UNDER APPLICABLE SECURITIES
LAWS TO UPDATE INFORMATION CONTAINED HEREIN OR INCORPORATED BY REFERENCE HEREIN,
NEITHER THE DELIVERY OF THIS PROSPECTUS NOR ANY SALE MADE HEREUNDER SHALL, UNDER
ANY CIRCUMSTANCES, CREATE ANY IMPLICATION THAT THE INFORMATION CONTAINED HEREIN
IS CORRECT AS OF ANY TIME SUBSEQUENT TO THE DATE HEREOF OR THAT THERE HAS BEEN
NO CHANGE IN THE AFFAIRS OF THE COMPANY SINCE THE DATE HEREOF.
 
                            ------------------------
 
                               TABLE OF CONTENTS
 
   
<TABLE>
<CAPTION>
                                                                            PAGE
                                                                            ----
<S>                                                                         <C>
Available Information.....................................................    2
Additional Information....................................................    2
Incorporation of Certain Documents by Reference...........................    2
The Company...............................................................    3
Risk Factors..............................................................    4
Use of Proceeds...........................................................   10
Dividend Policy...........................................................   10
Plan of Distribution......................................................   11
Description of Securities.................................................   12
Indemnification...........................................................   16
Legal Matters.............................................................   16
Experts...................................................................   16
</TABLE>
    
 
                                4,724,302 SHARES
 
                                     [LOGO]
 
                                  COMMON STOCK
 
                             ---------------------
 
                                   PROSPECTUS
 
                             ---------------------
 
   
                                NOVEMBER 5, 1997
    
 
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>
                                    PART II
                     INFORMATION NOT REQUIRED IN PROSPECTUS
 
ITEM 14. OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.
 
    The following table sets forth the costs and expenses, payable by the
Company in connection with this update of the Prospectus dated March 13, 1996
and the estimated expenses of periodic updates of this Prospectus. All amounts
are estimates except the SEC registration fee and the NASD filing fee.
 
   
<TABLE>
<CAPTION>
                                                                             AMOUNT TO BE PAID
                                                                             -----------------
<S>                                                                          <C>
Legal fees and expenses....................................................      $  10,000
Accounting fees and expenses...............................................              0
Transfer Agent and Registrar fees..........................................          5,000
                                                                                   -------
Total......................................................................      $  15,000
                                                                                   -------
                                                                                   -------
</TABLE>
    
 
ITEM 15. INDEMNIFICATION OF DIRECTORS AND OFFICERS.
 
   
    Section 145 of the Delaware General Corporation's Law authorizes a
corporation to indemnify its directors, officers, employees or other agents in
terms sufficiently broad to permit indemnification (including reimbursement for
expenses incurred) under certain circumstances for liabilities arising under the
Securities Act. The Company's Certificate of Incorporation (Exhibit 3.1 hereto)
and Bylaws (Exhibit 3.2 hereto) provide indemnification of its directors and
officers to the maximum extent permitted by the Delaware General Corporation
Law. In addition, the Company has entered into Indemnification Agreements
(Exhibit 10.1 hereto) with its directors and officers. Reference is also made to
Section 8 of the Underwriting Agreement contained in Exhibit 1.1 hereto,
indemnifying officers and directors of the Registrant against certain
liabilities.
    
 
                                      II-1
<PAGE>
ITEM 16. EXHIBITS.
 
    (a) Exhibits
 
   
<TABLE>
<CAPTION>
   EXHIBIT                                                                                            SEQUENTIALLY
   NUMBER                                   DESCRIPTION OF DOCUMENT                                   NUMBERED PAGE
- -------------  ----------------------------------------------------------------------------------  -------------------
<C>            <S>                                                                                 <C>
   (a)   1.1   Form of Underwriting Agreement.
   (c)   3.1   Certificate of Incorporation of the Registrant.
   (c)   3.2   Bylaws of the Registrant.
   (a)   4.1   Specimen Common Stock Certificate.
   (a)   4.2   Form of Representative's Warrant.
   (a)   4.3   Form of Warrant Agreement (including form of Common Stock Purchase Warrant).
         5.1   Opinion of Wilson Sonsini Goodrich & Rosati, P.C.
        10.1   Form of Indemnification Agreement between the Registrant and each of its directors
               and officers.
   (g)  10.2   1993 Stock Option Plan, as amended and restated effective February 3, 1997, and
               forms of stock option agreements thereunder.
   (g)  10.3   1996 Directors' Stock Option Plan, as amended effective February 3, 1997, and form
               of stock option agreement thereunder.
   (a)  10.4   Sublease Agreement dated March 25, 1991 between the Registrant and Jelly Bean
               Square, a California general partnership, as amended.
   (a)  10.5   Sublease Agreement dated June 29, 1993 between the Registrant and Jelly Bean
               Square, a California general partnership, as amended.
   (a)  10.6   Lease Agreement dated September 26, 1994 between the Registrant and Arthur J.
               Rogers & Co., as amended.
  (a)(i)10.7   Patent Royalty Agreement dated June 30, 1992 between the Registrant and Progenics,
               Inc.
  (a)(i)10.8   Patent License and Royalty Agreement dated August 30, 1993 between the Registrant
               and The Jackson Laboratory.
  (a)(i)10.9   Worldwide License Agreement dated March 1, 1994 between the Registrant and Janssen
               Biotech, N.V.
  (a)(i)10.10  Patent License Agreement dated March 1, 1994 between the Registrant and Cyclex
               Inc.
  (a)(i)10.11  Patent License and Royalty Agreement dated November 15, 1993 between the
               Registrant and The Long Island Jewish Medical Center.
  (a)(i)10.12  License Agreement dated February 1, 1995 between the Registrant and Pharmos
               Corporation.
   (a)  10.13  Research and License Agreement dated August 1, 1993 between the Registrant and
               Amur Research Corp.
   (g)  10.14  Common Stock Sale/Repurchase Agreement dated August 6, 1997 between Israel
               Chemicals, Ltd. and the Registrant.
   (a)  10.15  Employment, Confidential Information and Invention Assignment Agreement dated
               January 1, 1994 between the Registrant and Joseph Rubinfeld and form of amendment.
   (a)  10.16  Employment, Confidential Information and Invention Assignment Agreement dated
               February 1, 1994 between the Registrant and Frank Brenner.
   (a)  10.17  Form of Consulting Agreement between the Registrant and J. Gregory Swendsen and
               David M. Fineman.
   (a)  10.18  Consulting Agreement between the Registrant and Vida International Pharmaceutical
               Consultants.
</TABLE>
    
 
                                      II-2
<PAGE>
   
<TABLE>
<CAPTION>
   EXHIBIT                                                                                            SEQUENTIALLY
   NUMBER                                   DESCRIPTION OF DOCUMENT                                   NUMBERED PAGE
- -------------  ----------------------------------------------------------------------------------  -------------------
<C>            <S>                                                                                 <C>
   (b)  10.19  Purchase and Sale Agreement dated as of September 30, 1996 between the Registrant
               and Warner-Lambert Company, a Delaware corporation.
  (d)(i)10.20  Asset Purchase Agreement dated January 15, 1997 between the Registrant and Immunex
               Corporation, a Washington corporation.
   (d)  10.21  Standard Offer, Agreement and Escrow Instructions for Purchase of Real Estate
               (Non-Residential) dated December 11, 1996 between the Registrant and The Ashwill
               Trust, established November 8, 1989.
   (d)  10.22  Bishop Ranch Business Park Building Lease dated October 14, 1996 between the
               Registrant and Annabel Investment Company, a California partnership.
 (e)(i) 10.23  License Agreement between Inflazyme Pharmaceuticals Ltd. and the Registrant dated
               April 11, 1997.
 (e)(i) 10.24  Supply Agreement dated May 7, 1997.
   (e)  10.25  Assignment and Assumption Agreement between the Registrant and R&S, LLC, dated
               April 17, 1997.
   (f)  10.26  Convertible Secured Note, Option and Warrant Purchase Agreement dated June 17,
               1997 among the Registrant, Tako Ventures, LLC and, solely as to Sections 5.3 and
               5.5 thereof, Lawrence J. Ellison.
   (a)  10.27  Form of Common Stock Purchase Agreement among the purchasers and the Registrant
               dated August 29, 1997.
 (i)(a) 10.28  License Agreement between Stehlin Foundation and the Registrant dated September 3,
               1997.
   (h)  10.29  Employees and Consultants Stock Option Agreement/Plan.
   (a)  10.30  Letter Agreement dated August 13, 1997 between the Registrant and South Bay
               Construction, Inc.
 (j)(k) 10.31  Supply Agreement dated October 20, 1997 between the Registrant and Warner-Lambert
               Company.
        10.32  Standard Industrial/Commercial Multi-Tenant Lease dated October 13, 1997 between
               R&S, LLC and Quark Biotech, Inc.
   (a)  23.1   Consent of Ernst & Young LLP, Independent Auditors.
        23.2   Consent of Counsel (included in Exhibit 5.1).
   (a)  24.1   Power of Attorney.
</TABLE>
    
 
- ------------------------
 
(a) Previously filed.
 
(b) Incorporated by reference from the Registrant's Report on Form 8-K filed
    with the Securities and Exchange Commission on October 15, 1996. The exhibit
    listed is incorporated by reference to Exhibit 2.1 of Registrant's Report on
    Form 8-K.
 
(c) Incorporated by reference from the Registrant's Proxy Statement filed with
    the Securities and Exchange Commission on April 25, 1997. Exhibits 3.3 and
    3.5 listed are incorporated by reference to Exhibits B and C, respectively,
    of Registrant's Proxy Statement.
 
(d) Incorporated by reference from the Registrant's Report on Form 10-K filed
    with the Securities and Exchange Commission on March 31, 1997. Exhibits
    10.20, 10.21 and 10.22 listed are incorporated by reference to Exhibits
    10.22, 10.23 and 10.24 respectively, of Registrant's Report on Form 10-K.
 
(e) Incorporated by reference from the Registrant's Report on Form 10-Q filed
    with the Securities and Exchange Commission on May 15, 1997. Exhibits 10.23,
    10.24 and 10.25 listed are incorporated by reference to Exhibits 10.25,
    10.26 and 10.27, respectively, of Registrant's Report on Form 10-Q.
 
                                      II-3
<PAGE>
(f) Incorporated by reference from the Registrant's Report on Form 8-K filed
    with the Securities and Exchange Commission on July 2, 1997. The exhibit
    listed is incorporated by reference to Exhibit 99.1 of Registrant's Report
    on Form 8-K.
 
(g) Incorporated by reference from the Registrant's Report on Form 10-Q filed
    with the Securities and Exchange Commission on August 13, 1997. Exhibits
    10.2, 10.3 and 10.14 listed are incorporated by reference to Exhibits 10.2,
    10.3 and 10.14, respectively, of Registrant's Report on Form 10-Q.
 
(h) Incorporated by reference from the Registrant's Report on Form S-8 filed
    with the Securities and Exchange Commission on July 1, 1996. The exhibit
    listed is incorporated by reference to Exhibit 4.3 of Registrant's Report on
    Form S-8.
 
(i) Confidential treatment has been previously granted for certain portions of
    these exhibits.
 
(j) Confidential treatment has been requested for certain portions of this
    exhibit.
 
   
(k) Incorporated by reference from the Registrant's Report on Form 8-K filed
    with the Securities and Exchange Commission on October 31, 1997. The Exhibit
    listed is incorporated by reference to Exhibit 10.1 of Registrant's Report
    on Form 8-K.
    
 
ITEM 17. UNDERTAKINGS.
 
    Insofar as indemnification for liabilities arising under the Securities Act
may be permitted to directors, officers and controlling persons of the
Registrant pursuant to the foregoing provisions, or otherwise, the Registrant
has been advised that in the opinion of the Securities and Exchange Commission
such indemnification is against public policy as expressed in the Securities
Act, and is, therefore, unenforceable. In the event that a claim for
indemnification against such liabilities (other than the payment by the
Registrant of expenses incurred or paid by a director, officer, or controlling
person of the Registrant in the successful defense of any action, suit or
proceeding) is asserted by such director, officer or controlling person in
connection with the securities being registered, the Registrant will, unless in
the opinion of its counsel the matter has been settled by controlling precedent,
submit to a court of appropriate jurisdiction the question whether such
indemnification by it is against public policy as expressed in the Securities
Act and will be governed by the final adjudication of such issue.
 
    The Registrant hereby undertakes that:
 
(1) For purposes of determining any liability under the Securities Act, the
    information omitted from the form of Prospectus filed as part of this
    Registration Statement in reliance upon Rule 430A and contained in a form of
    Prospectus filed by the Registrant pursuant to Rule 424(b)(1) or (4) or
    497(h) under the Securities Act shall be deemed to be part of this
    Registration Statement as of the time it was declared effective.
 
(2) For the purposes of determining any liability under the Securities Act, each
    post-effective amendment that contains a form of prospectus shall be deemed
    to be a new registration statement relating to the securities offered
    therein, and the offering of such securities at that time shall be deemed to
    be the initial bona fide offering thereof.
 
                                      II-4
<PAGE>
                                   SIGNATURES
 
   
    In accordance with the requirements of the Securities Act of 1933, the
Registrant certifies it has reasonable grounds to believe that it meets all of
the requirements of filing on Form S-3 and authorizes this Post-Effective
Amendment on Form S-3 to the Registration Statement on Form SB-2 to be signed on
its behalf by the undersigned, in the City of San Ramon, State of California, on
the 4th day of November, 1997.
    
 
<TABLE>
<S>                             <C>  <C>
                                SUPERGEN, INC.
 
                                By:             /s/ JOSEPH RUBINFELD
                                     -----------------------------------------
                                                  Joseph Rubinfeld
                                              CHIEF EXECUTIVE OFFICER,
                                               PRESIDENT AND DIRECTOR
</TABLE>
 
    In accordance with the requirements of the Securities Act of 1933, this
Registration Statement was signed by the following persons in the capacities
stated.
 
   
          SIGNATURE                       TITLE                    DATE
- ------------------------------  --------------------------  -------------------
                                Chief Executive Officer,
     /s/ JOSEPH RUBINFELD         President and Director
- ------------------------------    (Principal Executive       November 4, 1997
       Joseph Rubinfeld           Officer)
 
   /s/ HENRY C. SETTLE, JR.     Chief Financial Officer
- ------------------------------    (Principal Financial and   November 4, 1997
     Henry C. Settle, Jr.         Accounting Officer)
 
- ------------------------------  Director
     Lawrence J. Ellison
 
    /s/ DAVID M. FINEMAN*
- ------------------------------  Director                     November 4, 1997
       David M. Fineman
 
   /s/ J. GREGORY SWENDSEN*
- ------------------------------  Director                     November 4, 1997
     J. Gregory Swendsen
 
       /s/ DANIEL ZURR*
- ------------------------------  Director                     November 4, 1997
         Daniel Zurr
 
      /s/ DENIS BURGER*
- ------------------------------  Director                     November 4, 1997
         Denis Burger
 
       /s/ JULIUS VIDA*
- ------------------------------  Director                     November 4, 1997
         Julius Vida
 
    
 
*By:    /s/ JOSEPH RUBINFELD
      -------------------------
          Joseph Rubinfeld
          ATTORNEY-IN-FACT
 
                                      II-5
<PAGE>
                               INDEX TO EXHIBITS
 
   
<TABLE>
<CAPTION>
   EXHIBIT                                                                                            SEQUENTIALLY
   NUMBER                                   DESCRIPTION OF DOCUMENT                                   NUMBERED PAGE
- -------------  ----------------------------------------------------------------------------------  -------------------
<C>            <S>                                                                                 <C>
   (a)   1.1   Form of Underwriting Agreement.
   (c)   3.1   Certificate of Incorporation of the Registrant.
   (c)   3.2   Bylaws of the Registrant.
   (a)   4.1   Specimen Common Stock Certificate.
   (a)   4.2   Form of Representative's Warrant.
   (a)   4.3   Form of Warrant Agreement (including form of Common Stock Purchase Warrant).
         5.1   Opinion of Wilson Sonsini Goodrich & Rosati, P.C.
        10.1   Form of Indemnification Agreement between the Registrant and each of its directors
               and officers.
   (g)  10.2   1993 Stock Option Plan, as amended and restated effective February 3, 1997, and
               forms of stock option agreements thereunder.
   (g)  10.3   1996 Directors' Stock Option Plan, as amended effective February 3, 1997, and form
               of stock option agreement thereunder.
   (a)  10.4   Sublease Agreement dated March 25, 1991 between the Registrant and Jelly Bean
               Square, a California general partnership, as amended.
   (a)  10.5   Sublease Agreement dated June 29, 1993 between the Registrant and Jelly Bean
               Square, a California general partnership, as amended.
   (a)  10.6   Lease Agreement dated September 26, 1994 between the Registrant and Arthur J.
               Rogers & Co., as amended.
  (a)(i)10.7   Patent Royalty Agreement dated June 30, 1992 between the Registrant and Progenics,
               Inc.
  (a)(i)10.8   Patent License and Royalty Agreement dated August 30, 1993 between the Registrant
               and The Jackson Laboratory.
  (a)(i)10.9   Worldwide License Agreement dated March 1, 1994 between the Registrant and Janssen
               Biotech, N.V.
  (a)(i)10.10  Patent License Agreement dated March 1, 1994 between the Registrant and Cyclex
               Inc.
  (a)(i)10.11  Patent License and Royalty Agreement dated November 15, 1993 between the
               Registrant and The Long Island Jewish Medical Center.
  (a)(i)10.12  License Agreement dated February 1, 1995 between the Registrant and Pharmos
               Corporation.
   (a)  10.13  Research and License Agreement dated August 1, 1993 between the Registrant and
               Amur Research Corp.
   (g)  10.14  Common Stock Sale/Repurchase Agreement dated August 6, 1997 between Israel
               Chemicals, Ltd. and the Registrant.
   (a)  10.15  Employment, Confidential Information and Invention Assignment Agreement dated
               January 1, 1994 between the Registrant and Joseph Rubinfeld and form of amendment.
   (a)  10.16  Employment, Confidential Information and Invention Assignment Agreement dated
               February 1, 1994 between the Registrant and Frank Brenner.
   (a)  10.17  Form of Consulting Agreement between the Registrant and J. Gregory Swendsen and
               David M. Fineman.
   (a)  10.18  Consulting Agreement between the Registrant and Vida International Pharmaceutical
               Consultants.
   (b)  10.19  Purchase and Sale Agreement dated as of September 30, 1996 between the Registrant
               and Warner-Lambert Company, a Delaware corporation.
  (d)(i)10.20  Asset Purchase Agreement dated January 15, 1997 between the Registrant and Immunex
               Corporation, a Washington corporation.
</TABLE>
    
<PAGE>
   
<TABLE>
<CAPTION>
   EXHIBIT                                                                                            SEQUENTIALLY
   NUMBER                                   DESCRIPTION OF DOCUMENT                                   NUMBERED PAGE
- -------------  ----------------------------------------------------------------------------------  -------------------
<C>            <S>                                                                                 <C>
   (d)  10.21  Standard Offer, Agreement and Escrow Instructions for Purchase of Real Estate
               (Non-Residential) dated December 11, 1996 between the Registrant and The Ashwill
               Trust, established November 8, 1989.
   (d)  10.22  Bishop Ranch Business Park Building Lease dated October 14, 1996 between the
               Registrant and Annabel Investment Company, a California partnership.
 (e)(i) 10.23  License Agreement between Inflazyme Pharmaceuticals Ltd. and the Registrant dated
               April 11, 1997.
 (e)(i) 10.24  Supply Agreement dated May 7, 1997.
   (e)  10.25  Assignment and Assumption Agreement between the Registrant and R&S, LLC, dated
               April 17, 1997.
   (f)  10.26  Convertible Secured Note, Option and Warrant Purchase Agreement dated June 17,
               1997 among the Registrant, Tako Ventures, LLC and, solely as to Sections 5.3 and
               5.5 thereof, Lawrence J. Ellison.
   (a)  10.27  Form of Common Stock Purchase Agreement among the purchasers and the Registrant
               dated August 29, 1997.
  (i)(a)10.28  License Agreement between Stehlin Foundation and the Registrant dated September 3,
               1997.
   (h)  10.29  Employees and Consultants Stock Option Agreement/Plan.
   (a)  10.30  Letter Agreement dated August 13, 1997 between the Registrant and South Bay
               Construction, Inc.
  (j)(k)10.31  Supply Agreement dated October 20, 1997 between the Registrant and Warner-Lambert
               Company.
        10.32  Standard Industrial/Commercial Multi-Tenant Lease dated October 13, 1997 between
               R&S, LLC and Quark Biotech, Inc.
   (a)  23.1   Consent of Ernst & Young LLP, Independent Auditors.
        23.2   Consent of Counsel (included in Exhibit 5.1).
   (a)  24.1   Power of Attorney.
</TABLE>
    
 
- ------------------------
 
(a) Previously filed.
 
(b) Incorporated by reference from the Registrant's Report on Form 8-K filed
    with the Securities and Exchange Commission on October 15, 1996. The exhibit
    listed is incorporated by reference to Exhibit 2.1 of Registrant's Report on
    Form 8-K.
 
(c) Incorporated by reference from the Registrant's Proxy Statement filed with
    the Securities and Exchange Commission on April 25, 1997. Exhibits 3.3 and
    3.5 listed are incorporated by reference to Exhibits B and C, respectively,
    of Registrant's Proxy Statement.
 
(d) Incorporated by reference from the Registrant's Report on Form 10-K filed
    with the Securities and Exchange Commission on March 31, 1997. Exhibits
    10.20, 10.21 and 10.22 listed are incorporated by reference to Exhibits
    10.22, 10.23 and 10.24 respectively, of Registrant's Report on Form 10-K.
 
(e) Incorporated by reference from the Registrant's Report on Form 10-Q filed
    with the Securities and Exchange Commission on May 15, 1997. Exhibits 10.23,
    10.24 and 10.25 listed are incorporated by reference to Exhibits 10.25,
    10.26 and 10.27, respectively, of Registrant's Report on Form 10-Q.
 
(f) Incorporated by reference from the Registrant's Report on Form 8-K filed
    with the Securities and Exchange Commission on July 2, 1997. The exhibit
    listed is incorporated by reference to Exhibit 99.1 of Registrant's Report
    on Form 8-K.
 
(g) Incorporated by reference from the Registrant's Report on Form 10-Q filed
    with the Securities and Exchange Commission on August 13, 1997. Exhibits
    10.2, 10.3 and 10.14 listed are incorporated by reference to Exhibits 10.2,
    10.3 and 10.14, respectively, of Registrant's Report on Form 10-Q.
 
(h) Incorporated by reference from the Registrant's Report on Form S-8 filed
    with the Securities and Exchange Commission on July 1, 1996. The exhibit
    listed is incorporated by reference to Exhibit 4.3 of Registrant's Report on
    Form S-8.
<PAGE>
(i) Confidential treatment has been previously granted for certain portions of
    these exhibits.
 
(j) Confidential treatment has been requested for certain portions of this
    exhibit.
 
   
(k) Incorporated by reference from the Registrant's Report on Form 8-K filed
    with the Securities and Exchange Commission on October 31, 1997. The Exhibit
    listed is incorporated by reference to Exhibit 10.1 of Registrant Report on
    Form 8-K.
    

<PAGE>


                      WILSON SONSINI GOODRICH & ROSATI
                          PROFESSIONAL CORPORATION

                             650 Page Mill Road
                      Palo Alto, California 94304-1050
             TELEPHONE 650-493-9300     FACSIMILE 650-493-6811

                               EXHIBIT 5.1

                             November 4, 1997

SuperGen, Inc.
Two Annabel Lane, Suite 220
San Ramon, California 94583

     RE:  Registration Statement No. 333-476-LA on Form SB-2

Ladies and Gentlemen:

     We have examined the Registration Statement on Form SB-2 filed by you 
with the Securities and Exchange Commission on January 18, 1996 (Registration 
No. 333-476-LA), Amendment No. 1 thereto filed February 26, 1996, Amendment 
No. 2 thereto filed March 7, 1996, Post-Effective Amendment No. 1 on Form S-3 
filed August 15, 1997, Post-Effective Amendment No. 2 on Form S-3 filed 
October 6, 1997 and Post-Effective Amendment No. 3 on Form S-3 filed November 
4, 1997 (the "Registration Statement") relating to 4,024,302 shares of your 
Common Stock issuable upon the exercise of 4,024,302 warrants (the 
"Warrants") issued is connection with your initial public offering, 350,000 
shares of Common Stock and 350,000 Warrants issuable upon exercise of a 
warrant (the "Representative's Warrant") issued to Paulson Investment 
Company, Inc. and 350,000 shares of Common Stock issuable upon exercise of 
the Warrants included in the Representative's Warrant.

     It is our opinion that, assuming the delivery in accordance with the 
Securities Act of 1933, as amended, of a current prospectus relating to the 
Common Stock underlying the Warrants, the Representative's Warrant and the 
Warrants issuable upon exercise of the Representative's Warrant and assuming 
such Common Stock is qualified for sale or exempt from qualification under 
applicable state securities laws, such Common Stock when issued upon exercise 
of the applicable warrant in the manner specified in the Registration 
Statement and the Warrant Agreement dated March 2, 1996 relating the Warrants 
or the Representative's Warrant, as the case may be, will be legally and 
validly issued, fully paid and nonassessable.

     We consent to the use of this opinion as an exhibit to the Registration 
Statement, and further consent to the use of our name wherever appearing in 
the Registration Statement, including the prospectus constituting a part 
thereof, and any amendment thereto.

                                       Sincerely,

                                       WILSON SONSINI GOODRICH & ROSATI
                                       Professional Corporation

                                       /s/ WILSON SONSINI GOODRICH & ROSATI


<PAGE>


                        INDEMNIFICATION AGREEMENT
                                (As Amended)


         THIS INDEMNIFICATION AGREEMENT ("Agreement") is made as of this 
___day of _____, 1997 by and between SuperGen, Inc., a Delaware corporation 
(the "Company"), and ________________ ("Indemnitee").

         WHEREAS, SuperGen, Inc, a California corporation, and Indemnitee are 
parties to an indemnification agreement;

         WHEREAS, effective as of the date hereof, SuperGen, Inc., a 
California corporation, is incorporating into Delaware;

         WHEREAS, the Company and Indemnitee recognize the increasing 
difficulty in obtaining directors' and officers' liability insurance, the 
significant increases in the cost of such insurance and the general 
reductions in the coverage of such insurance;

         WHEREAS, the Company and Indemnitee further recognize the 
substantial increase in corporate litigation in general, subjecting officers 
and directors to expensive litigation risks at the same time as the 
availability and coverage of liability insurance has been severely limited;

         WHEREAS, in connection with the Company's reincorporation, the 
Company and Indemnitee desire to continue to have in place the additional 
protection provided by an indemnification agreement, with such changes as are 
required to conform the existing agreement to Delaware law and to provide 
indemnification and advancement of expenses to the Indemnitee to the maximum 
extent permitted by Delaware law; and 

         WHEREAS, the Company desires to attract and retain the services of 
highly qualified individuals, such as Indemnitee, to serve as officers and 
directors of the Company and to indemnify its officers and directors so as to 
provide them with the maximum protection permitted by law.

         NOW, THEREFORE, the Company and Indemnitee hereby agree as follows:

     1.  INDEMNIFICATION.

         (a)  THIRD PARTY PROCEEDINGS.  The Company shall indemnify 
Indemnitee if Indemnitee is or was a party or is threatened to be made a 
party to any threatened, pending or completed action or proceeding, whether 
civil, criminal, administrative or investigative (other than an action by or 
in the right of the Company) by reason of the fact that Indemnitee is or was 
a director, officer, employee or agent of the Company, or any subsidiary of 
the Company, by reason of any action or inaction on the part of Indemnitee 
while an officer or director, by reason of the fact that Indemnitee is or was 
a director or officer of the Corporation or by reason of the fact that 
Indemnitee is or was serving at the request of the Company as a director, 
officer, employee or agent of another corporation, partnership, joint 
venture, trust or other enterprise, against expenses (including

<PAGE>

attorneys' fees), judgments, fines and amounts paid in settlement (if such 
settlement is approved in advance by the Company, which approval shall not be 
unreasonably withheld) actually and reasonably incurred by Indemnitee in 
connection with such action or proceeding if Indemnitee acted in good faith 
and in a manner Indemnitee reasonably believed to be in, or not opposed to, 
the best interests of the Company, and, with respect to any criminal action 
or proceeding, had no reasonable cause to believe Indemnitee's conduct was 
unlawful.  The termination of any action or proceeding by judgment, order, 
settlement, conviction, or upon a plea of NOLO CONTENDERE or its equivalent, 
shall not, of itself, create a presumption that (i) Indemnitee did not act in 
good faith and in a manner which Indemnitee reasonably believed to be in, or 
not opposed to, the best interests of the Company, or (ii) with respect to 
any crim-inal action or proceeding, Indemnitee had reasonable cause to 
believe that Indemnitee's conduct was unlawful.

    (b)  PROCEEDINGS BY OR IN THE RIGHT OF THE COMPANY.  The Company shall 
indemnify Indemnitee if Indemnitee was or is a party or is threatened to be 
made a party to any threatened, pending or completed action or proceeding by 
or in the right of the Company or any subsidiary of the Company to procure a 
judgment in its favor by reason of the fact that Indemnitee is or was a 
director, officer, employee or agent of the Company, or any subsidiary of the 
Company, by reason of any action or inaction on the part of Indemnitee while 
an officer or director or by reason of the fact that Indemnitee is or was 
serving at the request of the Company as a director, officer, employee or 
agent of another corporation, partnership, joint venture, trust or other 
enterprise, against expenses (including attorneys' fees) and, to the fullest 
extent permitted by law, amounts paid in settlement, in each case to the 
extent actually and reason-ably incurred by Indemnitee in connection with the 
defense or settlement of such action or proceeding if Indemnitee acted in 
good faith and in a manner Indemnitee reasonably believed to be in, or not 
opposed to, the best interests of the Company, and its stockholders, except 
that no indemnification shall be made in respect of any claim, issue or 
matter as to which Indemnitee shall have been adjudged to be liable to the 
Company in the performance of Indemnitee's duty to the Company and its 
stockholders unless and only to the extent that the Delaware Court of 
Chancery or the court in which such action or proceeding was brought shall 
determine upon application that, despite the adjudication of liability but in 
view of all the circumstances of the case, Indemnitee is fairly and 
reasonably entitled to indemnity for such expenses which the Court of 
Chancery or such other court shall deem proper.

     2.  EXPENSES; INDEMNIFICATION PROCEDURE.

         (a)  ADVANCEMENT OF EXPENSES.  The Company shall advance all 
expenses incurred by Indemnitee in connection with the investigation, 
defense, settlement or appeal of any civil or criminal action or proceeding 
referenced in Section 1(a) or (b) hereof (but not amounts actually paid in 
settlement of any such action or proceeding, which shall be governed by 
Section 1(a)).  Indemnitee hereby undertakes to repay such amounts advanced 
only if, and to the extent that, it shall ultimately be determined that 
Indemnitee is not entitled to be indemnified by the Company as authorized 
hereby.  The advances to be made hereunder shall be paid by the Company to 
Indemnitee within twenty (20) days following delivery of a written request 
therefor by Indemnitee to the Company.

                                       2

<PAGE>


         (b)  NOTICE/COOPERATION BY INDEMNITEE.  Indemnitee shall, as a 
condition precedent to his right to be indemnified under this Agreement, give 
the Company notice in writing as soon as practicable of any claim made 
against Indemnitee for which indemnification will or could be sought under 
this Agreement, PROVIDED HOWEVER, that a delay in giving such notice shall 
not deprive Indemnitee of any right to be indemnified under this Agreement 
unless, and then only to the extent that, such delay is materially 
prejudicial to the defense of such claim.  Notice to the Company shall be 
directed to the Chief Executive Officer of the Company at the address shown 
on the signature page of this Agreement (or such other address as the Company 
shall designate in writing to Indemnitee).  Notice shall be deemed received 
three business days after the date postmarked if sent by domestic certified 
or registered mail, properly addressed; otherwise notice shall be deemed 
received when such notice shall actually be received by the Company.  In 
addition, Indemnitee shall give the Company such information and cooperation 
as it may reasonably require and as shall be within Indemnitee's power.

         (c)  PROCEDURE.  Any indemnification provided for in Section 1 shall 
be made no later than forty-five (45) days after receipt of the written 
request of Indemnitee.  If a claim under this Agreement, under any statute, 
or under any provision of the Company's Certificate of Incorporation or 
Bylaws providing for indemnification, is not paid in full by the Company 
within forty-five (45) days after a written request for payment thereof has 
first been received by the Company, Indemnitee may, but need not, at any time 
thereafter bring an action against the Company to recover the unpaid amount 
of the claim and, subject to Section 13 of this Agreement, Indemnitee shall 
also be entitled to be paid for the expenses (including attorneys' fees) of 
bringing such action.  It shall be a defense to any such action (other than 
an action brought to enforce a claim for expenses incurred in connection with 
any action or proceeding in advance of its final disposition) that Indemnitee 
has not met the standards of conduct which make it permissible under 
applicable law for the Company to indemnify Indemnitee for the amount 
claimed, but the burden of proving such defense shall be on the Company, and 
Indemnitee shall be entitled to receive interim payments of expenses pursuant 
to Subsection 2(a) unless and until such defense may be finally adjudicated 
by court order or judgment from which no further right of appeal exists.  It 
is the parties' intention that if the Company contests Indemnitee's right to 
indemnification, the question of Indemnitee's right to indemnification shall 
be for the court to decide, and neither the failure of the Company (including 
its Board of Directors, any committee or subgroup of the Board of Directors, 
independent legal counsel, or its stockholders) to have made a determination 
that indemnification of Indemnitee is proper in the circumstances because 
Indemnitee has met the applicable standard of conduct required by applicable 
law, nor an actual determination by the Company (including its Board of 
Directors, any committee or subgroup of the Board of Directors, independent 
legal counsel, or its stockholders) that Indemnitee has not met such 
applicable standard of conduct, shall create a presumption that Indemnitee 
has or has not met the applicable standard of conduct.

         (d)  NOTICE TO INSURERS.  If, at the time of the receipt of a notice 
of a claim pursuant to Section 2(b) hereof, the Company has director and 
officer liability insurance in effect, the Company shall give prompt notice 
of the commencement of such proceeding to the insurers in accordance with the 
procedures set forth in the respective policies.  The Company shall 
thereafter 

                                       3


<PAGE>

take all necessary or desirable action to cause such insurers to pay, on 
behalf of the Indemnitee, all amounts payable as a result of such proceeding 
in accordance with the terms of such policies.

         (e)  SELECTION OF COUNSEL.  In the event the Company shall be 
obligated under Section 2(a) hereof to pay the expenses of any proceeding 
against Indemnitee, the Company, if appropriate, shall be entitled to assume 
the defense of such proceeding, with counsel approved by Indemnitee, which 
approval shall not be unreasonably withheld, upon the delivery to Indemnitee 
of written notice of its election so to do.  After delivery of such notice, 
approval of such counsel by Indemnitee and the retention of such counsel by 
the Company, the Company will not be liable to Indemnitee under this 
Agreement for any fees of counsel subsequently incurred by Indemnitee with 
respect to the same proceeding, provided that (i) Indemnitee shall have the 
right to employ his counsel in any such proceeding at Indemnitee's expense; 
and (ii) if (A) the employment of counsel by Indemnitee has been previously 
authorized by the Company, (B) Indemnitee shall have reasonably concluded 
that there may be a conflict of interest between the Company and Indemnitee 
in the conduct of any such defense or (C) the Company shall not, in fact, 
have employed counsel to assume the defense of such proceeding, then the fees 
and expenses of Indemnitee's counsel shall be at the expense of the Company.

     3.  ADDITIONAL INDEMNIFICATION RIGHTS; NONEXCLUSIVITY.

         (a)  SCOPE.  Notwithstanding any other provision of this Agreement, 
the Company hereby agrees to indemnify the Indemnitee to the fullest extent 
per-mitted by law, notwithstanding that such indemnification is not 
specifically authorized by the other provisions of this Agreement, the 
Company's Certificate of Incorporation, the Company's Bylaws or by statute.  
In the event of any change, after the date of this Agreement, in any 
applicable law, statute or rule which expands the right of a Delaware 
corporation to indemnify a member of its board of directors or an officer, 
such changes shall be, IPSO FACTO, within the purview of Indemnitee's rights 
and Company's obligations, under this Agreement.  In the event of any change 
in any applicable law, statute or rule which narrows the right of a Delaware 
corporation to indemnify a member of its Board of Direc-tors or an officer, 
such changes, to the extent not otherwise required by such law, statute or 
rule to be applied to this Agreement shall have no effect on this Agreement 
or the parties' rights and obligations hereunder.

         (b)  NONEXCLUSIVITY.  The indemnification provided by this Agreement 
shall not be deemed exclusive of any rights to which Indemnitee may be 
entitled under the Company's Certificate of Incorporation, its Bylaws, any 
agreement, any vote of stockholders or disinterested directors, the General 
Corporation Law of the State of Delaware, or otherwise, both as to action in 
Indemnitee's official capacity and as to action in another capacity while 
holding such office.  The indemnification provided under this Agreement shall 
continue as to Indemnitee for any action taken or not taken while serving in 
an indemnified capacity even though he may have ceased to serve in such 
capacity at the time of any action or other covered proceeding.

     4.  PARTIAL INDEMNIFICATION.  If Indemnitee is entitled under any 
provision of this Agreement to indemnification by the Company for some or a 
portion of the expenses, judgments,

                                       4

<PAGE>

fines or penalties actually or reasonably incurred by him in the 
investigation, defense, appeal or settlement of any civil or criminal action 
or proceeding, but not, however, for the total amount there-of, the Company 
shall nevertheless indemnify Indemnitee for the portion of such expenses, 
judgments, fines or penalties to which Indemnitee is entitled.

     5.  MUTUAL ACKNOWLEDGMENT.  Both the Company and Indemnitee acknowledge 
that in certain instances, Federal law or applicable public policy may 
prohibit the Company from indemnifying its directors and officers under this 
Agreement or otherwise.  Indemnitee understands and acknowledges that the 
Company has under-taken or may be required in the future to undertake with 
the Securities and Exchange Commission to submit the question of 
indemnification to a court in certain circumstances for a determination of 
the Company's right under public policy to indemnify Indemnitee.

     6.  DIRECTORS' AND OFFICERS' LIABILITY INSURANCE.  The Company shall, 
from time to time, make the good faith determination whether or not it is 
practicable for the Company to obtain and maintain a policy or policies of 
insurance with reputable insurance companies providing the officers and 
directors of the Company with coverage for losses from wrongful acts, or to 
ensure the Company's performance of its indemnification obligations under 
this Agreement.  Among other considerations, the Company will weigh the costs 
of obtaining such insurance coverage against the protection afforded by such 
coverage.  In all policies of directors' and officers' liability insurance, 
Indemnitee shall be named as an insured in such a manner as to provide 
Indemnitee the same rights and benefits as are accorded to the most favorably 
insured of the Company's directors, if Indemnitee is a director; or of the 
Company's officers, if Indem-nitee is not a director of the Company but is an 
officer.  Notwithstanding the foregoing, the Company shall have no obligation 
to obtain or maintain such insurance if the Company determines in good faith 
that such insurance is not reasonably available, if the premium costs for 
such insurance are dis-proportionate to the amount of coverage provided, if 
the coverage provided by such insurance is limited by exclusions so as to 
provide an insufficient benefit, or if Indemnitee is covered by similar 
insurance maintained by a subsidiary or parent of the Company.

     7.  SEVERABILITY.  Nothing in this Agreement is intended to require or 
shall be construed as requiring the Company to do or fail to do any act in 
violation of applicable law.  The Company's inability, pursuant to court 
order, to perform its obligations under this Agreement shall not constitute a 
breach of this Agreement. The provisions of this Agreement shall be severable 
as provided in this Section 7.  If this Agreement or any portion hereof shall 
be invalidated on any ground by any court of competent jurisdiction, then the 
Company shall nevertheless indemnify Indemnitee to the full extent permitted 
by any applicable portion of this Agreement that shall not have been 
invalidated, and the balance of this Agreement not so invalidated shall be 
enforceable in accordance with its terms.

     8.  EXCEPTIONS.  Any other provision herein to the contrary 
notwithstanding, the Company shall not be obligated pursuant to the terms of 
this Agreement:

         (a)  EXCLUDED ACTS.  To indemnify Indemnitee for any acts or 
omissions or transactions from which a director may not be relieved of 
liability under applicable law.

                                       5

<PAGE>

         (b)  CLAIMS INITIATED BY INDEMNITEE.  To indemnify or advance 
expenses to Indemnitee with respect to proceedings or claims initiated or 
brought voluntarily by Indemnitee and not by way of defense, except with 
respect to proceedings brought to establish or enforce a right to 
indemnification under this Agreement or any other statute or law or otherwise 
as required under Section 145 of the Delaware General Corporation Law, but 
such indemnification or advancement of expenses may be provided by the 
Company in specific cases if the Board of Directors has approved the 
initiation or bringing of such suit; or

         (c)  LACK OF GOOD FAITH.  To indemnify Indemnitee for any expenses 
incurred by the Indemnitee with respect to any proceeding instituted by 
Indemnitee to enforce or interpret this Agreement, if a court of competent 
jurisdiction determines that each of the material assertions made by the 
Indemnitee in such proceeding was not made in good faith or was frivolous; or

         (d)  INSURED CLAIMS.  To indemnify Indemnitee for expenses or 
liabilities of any type whatsoever (including, but not limited to, judgments, 
fines, ERISA excise taxes or penalties, and amounts paid in settlement) which 
have been paid directly to Indemnitee by an insurance carrier under a policy 
of directors' and officers' liability insurance maintained by the Company; or

         (e)  CLAIMS UNDER SECTION 16(b).  To indemnify Indemnitee for 
expenses and the payment of profits inuring to and recoverable by the Company 
pursuant to Section 16(b) of the Securities Exchange Act of 1934, as amended, 
or any similar successor statute.

     9.  EFFECTIVENESS OF AGREEMENT.  To the extent that the indemnification 
permitted under the terms of certain provisions of this Agreement exceeds the 
scope of the indemnification provided for in the Delaware General Corporation 
Law, such provisions shall not be effective unless and until the Company's 
Certificate of Incorporation authorize such additional rights of 
indemnification.  In all other respects, the balance of this Agreement shall 
be effective as of the date set forth on the first page and may apply to acts 
or omissions of Indemnitee which occurred prior to such date if Indemnitee 
was an officer, director, employee or other agent of the Company, or was 
serving at the request of the Company as a director, officer, employee or 
agent of another corporation, partnership, joint venture, trust or other 
enterprise, at the time such act or omission occurred.

    10.  CONSTRUCTION OF CERTAIN PHRASES.

         (a)  For purposes of this Agreement, references to the "Company" 
shall include, in addition to the resulting corporation, any constituent 
corporation (including any constituent of a constituent) absorbed in a 
consolidation or merger which, if its separate existence had continued, would 
have had power and authority to indemnify its directors, officers, employees 
or agents, so that if Indemnitee is or was a director, officer, employee or 
agent of such constituent corporation, or is or was serving at the request of 
such constituent corporation as a director, officer, employee or agent of 
another corporation, partnership, joint venture, trust or other enterprise, 
Indemnitee shall stand in the same position under the provisions of this 
Agreement with respect to the resulting or surviving corporation as 
Indemnitee would have with respect to such constituent corporation if its 
separate existence had continued.

                                       6

<PAGE>


         (b)  For purposes of this Agreement, references to "other 
enterprises" shall include employee benefit plans; references to "fines" 
shall include any excise taxes assessed on Indemnitee with respect to an 
employee benefit plan; and references to "serving at the request of the 
Company" shall include any service as a director, officer, employee or agent 
of the Company which imposes duties on, or involves services by, such 
director, officer, employee or agent with respect to an employee benefit 
plan, its participants, or beneficiaries.

    11.  COUNTERPARTS.  This Agreement may be executed in one or more 
counterparts, each of which shall constitute an original.

    12.  SUCCESSORS AND ASSIGNS.  This Agreement shall be binding upon the 
Company and its successors and assigns, and shall inure to the benefit of 
Indemnitee and Indemnitee's estate, heirs, legal representatives and assigns.

    13.  ATTORNEYS' FEES.  In the event that any action is instituted by 
Indemnitee under this Agreement to enforce or interpret any of the terms 
hereof, Indemnitee shall be entitled to be paid all court costs and expenses, 
including reasonable attorneys' fees, incurred by Indemnitee with respect to 
such action, unless as a part of such action, the court of competent 
jurisdiction determines that each of the material assertions made by 
Indemnitee as a basis for such action were not made in good faith or were 
frivolous.  In the event of an action instituted by or in the name of the 
Company under this Agreement or to enforce or interpret any of the terms of 
this Agreement, Indemnitee shall be entitled to be paid all court costs and 
expenses, including attorneys' fees, incurred by Indemnitee in defense of 
such action (including with respect to Indemnitee's counterclaims and 
cross-claims made in such action), unless as a part of such action the court 
determines that each of Indemnitee's material defenses to such action were 
made in bad faith or were frivolous.

    14.  NOTICE.  All notices, requests, demands and other communications 
under this Agreement shall be in writing and shall be deemed duly given (i) 
if delivered by hand and receipted for by the party addressee, on the date of 
such receipt, or (ii) if mailed by domestic certified or registered mail with 
postage prepaid, on the third business day after the date postmarked.  
Addresses for notice to either party are as shown on the signature page of 
this Agreement, or as subsequently modified by written notice.

    15.  CONSENT TO JURISDICTION.  The Company and Indemnitee each hereby 
irrevocably consent to the jurisdiction of the courts of the State of 
Delaware for all purposes in connection with any action or proceeding which 
arises out of or relates to this Agreement and agree that any action 
instituted under this Agreement shall be commenced, prosecuted and continued 
only in the Court of Chancery of the State of Delaware in and for New Castle 
County, which shall be the exclusive and only proper forum for adjudicating 
such a claim.

    16.  CHOICE OF LAW.  This Agreement shall be governed by and its provisions 
construed in accordance with the laws of the State of Delaware as applied to 
contracts between Delaware residents entered into and to be performed entirely 
within Delaware.

                                       7

<PAGE>

    17.  INTEGRATION AND ENTIRE AGREEMENT.  This Agreement sets forth the 
entire understanding between the parties hereto and supersedes and merges all 
previous written and oral negotiations, commitments, understandings and 
agreements relating to the subject matter hereof between the parties hereto.

    18.  NO CONSTRUCTION AS EMPLOYMENT AGREEMENT.  Nothing contained in this 
Agreement shall be construed as giving Indemnitee any right to be retained in 
the employ of the Company or any of its subsidiaries or affiliated entities.

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement 
as of the date first above written.

                                       SUPERGEN, INC.


                                       By: ___________________________________
 
                                       Title: ________________________________

                                       Address:   Two Annabel Lane, Suite 220
                                                  San Ramon, CA  94583



AGREED TO AND ACCEPTED:

INDEMNITEE:

_______________________________________



Address: ______________________________

         ______________________________


                                       8

 




<PAGE>

                                                             Exhibit 10.32

*   any partial month at the commencement of the Lease Term
**  at midnight on the last day of the thirty-sixth (36th) full calendar month
    following the Commencement Date, subject to extension as described in the 
    attached Addendum, and to earlier termination as described in the Lease

     STANDARD INDUSTRIAL/COMMERCIAL MULTI-TENANT LEASE-MODIFIED NET
               AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION

                                   AIR

1.   BASIC PROVISIONS ("BASIC PROVISIONS")
     1.1  PARTIES:  This Lease ("LEASE"), dated for reference purposes only, 
__________________________, 19__, is made by and between R&S, LLC, a 
California limited liability company ("LESSOR") and Quark Biotech, Inc., a 
California corporation ("LESSEE"), (collectively the "PARTIES," or 
individually a "PARTY").
    1.2(a) PREMISES:  That certain portion of the Building, including all 
improvements therein or to be provided by Lessor under the terms of this 
Lease, commonly known by the street address of 1059 Serpentine Lane, located 
in the City of Pleasanton , County of Alameda, State of California, with zip 
code _________ , as outlined on Exhibit   A attached hereto ("PREMISES").  
The "BUILDING" is that certain building containing the Premises and generally 
described as (describe briefly the nature of the Building): that certain 
approximately 9,600 square foot building located on the Premises.  In 
addition to Lessee's rights to use and occupy the Premises as hereinafter 
specified, Lessee shall have non-exclusive rights to the Common Areas (as 
defined in Paragraph 2.7 below) as hereinafter specified, but shall not have 
any rights to the roof, exterior walls or utility raceways of the Building or 
to any other buildings in the Industrial Center.  The Premises, the Building, 
the Common Areas, the land upon which they are located, along with all other 
buildings and improvements thereon, are herein collectively referred to as 
the "INDUSTRIAL CENTER."  (Also see Paragraph 2.)
   1.2(b) PARKING: _______________________________ unreserved vehicle parking 
spaces ("UNRESERVED PARKING SPACES"); and   N/A  reserved vehicle parking 
spaces ("RESERVED PARKING SPACES").  (Also see Paragraph 2.6.)
   1.3  TERM: Three (3) years and  *  months ("ORIGINAL TERM") commencing See 
attached Addendum. ("COMMENCEMENT DATE") and ending  **  ("EXPIRATION DATE"). 
(Also see Paragraph 3.)
   1.4  EARLY POSSESSION: N/A ("EARLY POSSESSION DATE"). (Also see Paragraphs 
3.2 and 3.3.)
   1.5  BASE RENT: $ 3,287 per month ("BASE RENT"), payable on the first 
(1st) day of each month commencing on the Commencement Date. (Also see 
Paragraph 4.)
[X]     If this box is checked, this Lease provides for the Base Rent to be
adjusted per Addendum One , attached hereto.
   1.6(a) BASE RENT PAID UPON EXECUTION: $ 3,287 as Base Rent for the period 
first month of the Term.
   1.6(b) LESSEE'S SHARE OF COMMON AREA OPERATING EXPENSES: Thirty-Four & 
24/100 percent (34.24%) ("LESSEE'S SHARE").
   1.7  SECURITY DEPOSIT: $ 3,287 ("SECURITY DEPOSIT"). (Also see Paragraph 5.)
   1.8  PERMITTED USE: general office, administrative and permitted 
laboratory uses. ("PERMITTED USE").  (Also see Paragraph 6.)
   1.9  INSURING PARTY. Lessor is the "INSURING PARTY." (Also see Paragraph 6.)
   1.10 ADDENDA AND EXHIBITS.  Attached hereto is an Addendum or Addenda 
consisting of Paragraphs 1 through 13, and Exhibits A through B, all of which 
constitute a part of this Lease.

2.   PREMISES, PARKING AND COMMON AREAS.

     2.1 LETTING. Lessor hereby leases to Lessee, and Lessee hereby leases 
from Lessor, the Premises, for the term, at the rental, and upon all of the 
terms, covenants and conditions set forth in this Lease.  Unless otherwise 
provided herein, any statement of square footage set forth in this Lease, or 
that may have been used in calculating rental and/or Common Area Operating 
Expenses, is an approximation which Lessor and Lessee agree is reasonable and 
the rental and Lessee's Share (as defined in Paragraph 1.6(b)) based thereon 
is not subject to revision whether or not the actual square footage is more 
or less.

    2.2 CONDITION. Lessor shall deliver the Premises to Lessee clean and free 
of debris on the Commencement Date and warrants to Lessee that the existing 
plumbing, electrical systems, fire sprinkler system, lighting, air 
conditioning and heating systems and loading doors, if any, in the Premises, 
other than those constructed by Lessee, shall be in good operating condition 
on the Commencement Date.  If a noncompliance with said warranty exists as of 
the Commencement Date, Lessor shall, except as otherwise provided in this 
Lease, promptly after receipt of written notice from Lessee setting forth 
with specificity the nature and extent of such noncompliance, rectify same at 
Lessor's expense.  If Lessee does not give Lessor written notice of a 
noncompliance with this warranty within thirty (30) days after the 
Commencement Date, correction of that noncompliance shall be the obligation 
of Lessee at Lessee's sole cost and expense.

    2.3 COMPLIANCE WITH COVENANTS, RESTRICTIONS AND BUILDING CODE. Lessor 
warrants that any improvements (other than those constructed by Lessee or at 
Lessee's direction) on or in the Premises which have been constructed or 
installed by Lessor or with Lessor's consent or at Lessor's direction shall 
comply with all applicable covenants or restrictions of record and applicable 
building codes, regulations and ordinances in effect on the Commencement 
Date.  Lessor further warrants to Lessee that Lessor has no knowledge of any 
claim having been made by any governmental agency that a violation or 
violations of applicable building codes, regulations, or ordinances exist 
with regard to the Premises as of the Commencement Date.  Said warranties 
shall not apply to any Alterations or Utility Installations (defined in 
Paragraph 7.3(a)) made or to be made by Lessee. If the Premises do not comply 
with said warranties, Lessor shall, except as otherwise provided in this 
Lease, promptly after receipt of written notice from Lessee given within six 
(6) months following the Commencement Date and setting forth with specificity 
the nature and extent of such noncompliance, take such action, at Lessor's 
expense, as may be reasonable or appropriate to rectify the noncompliance.  
Lessor makes no warranty that the Permitted Use in Paragraph 1.8 is permitted 
for the Premises under Applicable Law (as defined in Paragraph 2.4).

    2.4 ACCEPTANCE OF PREMISES. Lessee hereby acknowledges:  (a) that it has 
been advised by the Broker(s) to satisfy itself with respect to the condition 
of the Premises (including but not limited to the electrical and fire 
sprinkler systems, security, environmental aspects, seismic and earthquake 
requirements, and compliance with the Americans with Disabilities Act and 
applicable zoning, municipal, county, state and federal laws, ordinances and 
regulations and any covenants or restrictions of record (collectively, 
"APPLICABLE LAWS") and the present and future suitability of the Premises for 
Lessee's intended use; (b) that Lessee has made such investigation as it 
deems necessary with reference to such matters, is satisfied with reference 
thereto, and assumes all responsibility therefore as the same relate to 
Lessee's occupancy of the Premises and/or the terms of this Lease; and (c) 
that neither Lessor, nor any of Lessor's agents, has made any oral or written 
representations or warranties with respect to said matters other than as set 
forth in this Lease.

    2.5  LESSEE AS PRIOR OWNER/OCCUPANT. The warranties made by Lessor in 
this Paragraph 2 shall be of no force or effect if immediately prior to the 
date set forth in Paragraph 1.1 Lessee was the owner or occupant of the 
Premises. In such event, Lessee shall, at Lessee's sole cost and expense, 
correct any non-compliance of the Premises with said warranties.

    2.6  VEHICLE PARKING. Lessee shall be entitled to use the number of 
Unreserved Parking Spaces specified in Paragraph 1.2(b) on those portions of 
the Common Areas designated from time to time by Lessor for parking. Lessee 
shall not use more parking spaces than said number. Said parking spaces shall 
be used for parking by vehicles no larger than full-size passenger 
automobiles or pick-up trucks, herein called "PERMITTED SIZE VEHICLES." 
Vehicles other than Permitted Size Vehicles shall be parked and loaded or 
unloaded as directed by Lessor in the Rules and Regulations (as defined in 
Paragraph 40) issued by Lessor. (Also see Paragraph 2.9.)

         (a) Lessee shall not permit or allow any vehicles that belong to or 
are controlled by Lessee or Lessee's employees, suppliers, shippers, 
customers, contractors or invites to be loaded, unloaded, or parked in areas 
other than those designated by Lessor for such activities.

<PAGE>

         (b)  If Lessee permits or allows any of the prohibited activities 
described in this Paragraph 2.6, then Lessor shall have the right, without 
notice, in addition to such other rights and remedies that it may have, to 
remove or tow away the vehicle involved and charge the cost to Lessee, which 
cost shall be immediately payable upon demand by Lessor.

         (c)  Lessor shall at the Commencement Date of this Lease, provide 
the parking facilities required by Applicable Law.

    2.7 COMMON AREAS - DEFINITION. The term "COMMON AREAS" is defined as all 
areas and facilities outside the Premises and within the exterior boundary 
line of the Industrial Center and interior utility raceways within the 
Premises that are provided and designated by the Lessor from time to time for 
the general non-exclusive use of Lessor, Lessee and other lessees of the 
Industrial Center and their respective employees, suppliers, shippers, 
customers, contractors and invites, including parking areas, loading and 
unloading areas, trash areas, roadways, sidewalks, walkways, parkways, 
driveways and landscaped areas.

    2.8  COMMON AREAS - LESSEE'S RIGHTS. Lessor hereby grants to Lessee, for 
the benefit of Lessee and its employees, suppliers, shippers, contractors, 
customers and invites, during the term of this Lease, the non-exclusive right 
to use, in common with others entitled to such use, the Common Areas as they 
exist from time to time, subject to any rights, powers, and privileges 
reserved by Lessor under the terms hereof or under the terms of any rules and 
regulations or restrictions governing the use of the Industrial Center. Under 
no circumstances shall the right herein granted to use the Common Areas be 
deemed to include the right to store any property, temporarily or 
permanently, in the Common Areas. Any such storage shall be permitted only by 
the prior written consent of Lessor or Lessor's designated agent, which 
consent may be revoked at any time. In the event that any unauthorized 
storage shall occur then Lessor shall have the right, without notice, in 
addition to such other rights and remedies that it may have, to remove the 
property and charge the cost to Lessee, which cost shall be immediately 
payable upon demand by Lessor.

    2.9  COMMON AREAS - RULES AND REGULATIONS. Lessor or such other person(s) 
as Lessor may appoint shall have the exclusive control and management of the 
Common Areas and shall have the right, from time to time, to establish, 
modify, amend and enforce reasonable Rules and Regulations with respect 
thereto in accordance with Paragraph 40. Lessee agrees to abide by and 
conform to all such Rules and Regulations, and to cause its employees, 
suppliers, shippers, customers, contractors and invites to so abide and 
conform. Lessor shall not be responsible to Lessee for the noncompliance with 
said rules and regulations by other lessees of the Industrial Center.

    2.10 COMMON AREAS - CHANGES. Lessor shall have the right, in Lessor's 
sole discretion, from time to time:

         (a)  To make changes to the Common Areas, including, without 
limitation, changes in the location, size, shape and number of driveways, 
entrances, parking spaces, parking areas, loading and unloading areas, 
ingress, egress, direction of traffic, landscaped areas, walkways and utility 
raceways; .

         (b)  To close temporarily any of the Common Areas for maintenance 
purposes so long as reasonable access to the Premises remains available;

         (c)  To designate other land outside the boundaries of the 
Industrial Center to be a part of the Common Areas;

         (d)  To add additional buildings and improvements to the Common 
Areas;

         (e)  To use the Common Areas while engaged in making additional 
improvements, repairs or alterations to the Industrial Center, or any portion 
thereof; and

         (f)  To do and perform such other acts and make such other changes 
in, to or with respect to the Common Areas and Industrial Center as Lessor 
may, in the exercise of sound business judgment, deem to be appropriate.

3.  TERM.

    3.1  TERM. The Commencement Date, Expiration Date and Original Term of 
this Lease are as specified in Paragraph 1.3.

    3.2  EARLY POSSESSION. If an Early Possession Date is specified in 
Paragraph 1.4 and if Lessee totally or partially occupies the Premises after 
the Early Possession Date but prior to the Commencement Date, the obligation 
to pay Base Rent shall be abated for the period of such early occupancy. All 
other terms of this Lease, however, (including but not limited to the 
obligations to pay Lessee's Share of Common Area Operating Expenses and to 
carry the insurance required by Paragraph 8) shall be in effect during such 
period. Any such early possession shall not affect nor advance the Expiration 
Date of the Original Term.

    3.3  DELAY IN POSSESSION. If for any reason Lessor cannot deliver 
possession of the Premises to Lessee by the Early Possession Date, if one is 
specified in Paragraph 1.4, or if no Early Possession Date is specified, by 
the Commencement Date, Lessor shall not be subject to any liability therefor, 
nor shall such failure affect the validity of this Lease, or the obligations 
of Lessee hereunder, or extend the term hereof, but in such case, Lessee 
shall not, except as otherwise provided herein, be obligated to pay rent or 
perform any other obligation of Lessee under the terms of this Lease until 
Lessor delivers possession of the Premises to Lessee. If possession of the 
Premises is not delivered to Lessee within sixty (60) days after the 
Commencement Date, Lessee may, at its option, by notice in writing to Lessor 
within ten (10) days after the end of said sixty (60) day period, cancel this 
Lease, in which event the parties shall be discharged from all obligations 
hereunder; provided further, however, that if such written notice of Lessee 
is not received by Lessor within said ten (10) day period, Lessee's right to 
cancel this Lease hereunder shall terminate and be of no further force or 
effect. Except as may be otherwise provided, and regardless of when the 
Original Term actually commences, if possession is not tendered to Lessee 
when required by this Lease and Lessee does not terminate this Lease, as 
aforesaid, the period free of the obligation to pay Base Rent, it any, that 
Lessee would otherwise have enjoyed shall run from the date of delivery of 
possession and continue for a period equal to the period during which the 
Lessee would have otherwise enjoyed under the terms hereof, but minus any 
days of delay caused by the acts, changes or omissions of Lessee.

4.  RENT.

    4.1 BASE RENT. Lessee shall pay Base Rent and other rent or charges, as 
the same may be adjusted from time to time, to Lessor in lawful money of the 
United States, without offset or deduction, on or before the day on which it 
is due under the terms of this Lease. Base Rent and all other rent and 
charges for any period during the term hereof which is for less than one full 
month shall be prorated based upon the actual number of days of the month 
involved. Payment of Base Rent and other charges shall be made to Lessor at 
its address stated herein or to such other persons or at such other addresses 
as Lessor may from time to time designate in writing to Lessee.

    4.2  COMMON AREA OPERATING EXPENSES. Lessee shall pay to Lessor during 
the term hereof, in addition to the Base Rent, Lessee's Share (as specified 
in Paragraph 1.6(b)) of all Common Area Operating Expenses, as hereinafter 
defined, during each calendar year of the term of this Lease, in accordance 
with the following provisions:

         (a)  "COMMON AREA OPERATING EXPENSES" are defined, for purposes of 
this Lease, as all costs incurred by Lessor relating to the ownership and 
operation of the Industrial Center, including, but not limited to, the 
following:

              (i)  The operation, repair and maintenance, in neat, clean, 
good order and condition, of the following:

                   (aa) The Common Areas, including parking areas, loading 
and unloading areas, trash areas, roadways, sidewalks, walkways, parkways, 
driveways, landscaped areas, striping, bumpers, irrigation systems, Common 
Area lighting facilities, fences and gates, elevators and roof.

                   (bb) Exterior signs and any tenant directories.

                   (cc) Fire detection and sprinkler systems.

              (ii)  The cost of water, gas, electricity and telephone to 
service the Common Areas.

              (iii) Trash disposal, property management and security 
services and the costs of any environmental inspections.

                               -2-

<PAGE>

              (iv)  Reserves set aside for maintenance and repair of Common 
Areas.

               (v)  Real Property Taxes (as defined in Paragraph 10.2) to be 
paid by Lessor for the Building and the Common Areas under Paragraph 10 
hereof.

              (vi)  The cost of the premiums for the insurance policies 
maintained by Lessor under Paragraph 8 hereof.

             (vii)  Any deductible portion of an insured loss concerning the 
Building or the Common Areas.

            (viii)  Any other services to be provided by Lessor that are 
stated elsewhere in this Lease to be a Common Area Operating Expense.

         (b)  Any Common Area Operating Expenses and Real Property Taxes that 
are specifically attributable to the Building or to any other building in the 
Industrial Center or to the operation, repair and maintenance thereof, shall 
be allocated entirely to the Building or to such other building.  However, 
any Common Area Operating Expenses and Real Property Taxes that are not 
specifically attributable to the Building or to any other building or to the 
operation, repair and maintenance thereof, shall be equitably allocated by 
Lessor to all buildings in the Industrial Center.

         (c)  The inclusion of the improvements, facilities and services set 
forth in Subparagraph 4.2(a) shall not be deemed to impose an obligation upon 
Lessor to either have said improvements or facilities or to provide those 
services unless the Industrial Center already has the same, Lessor already 
provides the services, or Lessor has agreed elsewhere in this Lease to 
provide the same or some of them.

         (d)  Lessee's Share of Common Area Operating Expenses shall be 
payable by Lessee within ten (10) days after a reasonably detailed statement 
of actual expenses is presented to Lessee by Lessor.  At Lessor's option, 
however, an amount may be estimated by Lessor from time to time of Lessee's 
Share of annual Common Area Operating Expenses and the same shall be payable 
monthly or quarterly, as Lessor shall designate, during each 12-month period 
of the Lease term, on the same day as the Base Rent is due hereunder.  Lessor 
shall deliver to Lessee within sixty (60) days after the expiration of each 
calendar year a reasonably detailed statement showing Lessee's Share of the 
actual Common Area Operating Expenses incurred during the preceding year.  If 
Lessee's payments under this Paragraph 4.2(d) during said preceding year 
exceed Lessee's Share as indicated on said statement, Lessor shall be 
credited the amount of such over-payment against Lessee's Share of Common 
Area Operating Expenses next becoming due. If Lessee's payments under this 
Paragraph 4.2(d) during said preceding year were less than Lessee's Share as 
indicated on said statement, Lessee shall pay to Lessor the amount of the 
deficiency within ten (10) days after delivery by Lessor to Lessee of said 
statement.

5. SECURITY DEPOSIT. Lessee shall deposit with Lessor upon Lessee's execution 
hereof the Security Deposit set forth in Paragraph 1.7 as security for 
Lessee's faithful performance of Lessee's obligations under this Lease.  If 
Lessee fails to pay Bass Rent or other rent or charges due hereunder, or 
otherwise Defaults under this Lease (as defined in Paragraph 13.1), Lessor 
may use, apply or retain all or any portion of said Security Deposit for the 
payment of any amount due Lessor or to reimburse or compensate Lessor for any 
liability, cost, expense, loss or damage (including attorneys' fees) which 
Lessor may suffer or incur by reason thereof.  If Lessor uses or applies all 
or any portion of said Security Deposit, Lessee shall within ten (10) days 
after written request therefore deposit monies with Lessor sufficient to 
restore said Security Deposit to the full amount required by this Lease.  Any 
time the Base Rent increases during the term of this Lease, Lessee shall, 
upon written request from Lessor, deposit additional monies with Lessor as an 
addition to the Security Deposit so that the total amount of the Security 
Deposit shall at all times bear the same proportion to the then current Base 
Rent as the initial Security Deposit bears to the initial Base Rent set forth 
in Paragraph 1.5. Lessor shall not be required to keep all or any part of the 
Security Deposit separate from its general accounts.  Lessor shall, at the 
expiration or earlier termination of the term hereof and after Lessee has 
vacated the Premises, return to Lessee (or, at Lessor's option, to the last 
assignee, if any, of Lessee's interest herein), that portion of the Security 
Deposit not used or applied by Lessor.  Unless otherwise expressly agreed in 
writing by Lessor, no part of the Security Deposit shall be considered to be 
held in trust, to bear interest or other increment for its use, or to be 
prepayment for any monies to be paid by Lessee under this Lease.

6.  USE.

    6.1  PERMITTED USE.

         (a)  Lessee shall use and occupy the Premises only for the Permitted 
Use set forth in Paragraph 1.8, or any other legal use which is reasonably 
comparable thereto, and for no other purpose.  Lessee shall not use or permit 
the use of the Premises in a manner that is unlawful, creates waste or a 
nuisance, or that disturbs owners and/or occupants of, or causes damage to 
the Premises or neighboring premises or properties.

         (b)  Lessor hereby agrees to not unreasonably withhold or delay its 
consent to any written request by Lessee, Lessee's assignees or subtenants, 
and by prospective assignees and subtenants of Lessee, its assignees and 
subtenants, for a modification of said Permitted Use, so long as the same 
will not impair the structural integrity of the improvements on the Premises 
or in the Building or the mechanical or electrical system therein, does not 
conflict with uses by other lessees, is not significantly more burdensome to 
the Premises or the Building and the improvements thereon, and is otherwise 
permissible pursuant to this Paragraph 6.  If Lessor elects to withhold such 
consent, Lessor shall within five (5) business days after such request give a 
written notification of same, which notice shall include an explanation of 
Lessor's reasonable objections to the change in use.

    6.2  HAZARDOUS SUBSTANCES.

         (a)  REPORTABLE USES REQUIRE CONSENT.  The term "HAZARDOUS 
SUBSTANCE" as used in this Lease shall mean any product, substance, chemical, 
material or waste whose presence, nature, quantity and/or intensity of 
existence, use, manufacture, disposal, transportation, spill, release or 
effect, either by itself or in combination with other materials expected to 
be on the Premises, is either: (i) potentially injurious to the public 
health, safety or welfare, the environment, or the Premises; (ii) regulated 
or monitored by any governmental authority; or (iii) a basis for potential 
liability of Lessor to any governmental agency or third party under any 
applicable statute or common law theory.  Hazardous Substance shall include, 
but not be limited to, hydrocarbons, petroleum, gasoline, crude oil or any 
products or by-products thereof.  Lessee shall not engage in any activity in 
or about the Premises which constitutes a Reportable Use (as hereinafter 
defined) of Hazardous Substances without the express prior written consent of 
Lessor and compliance in a timely manner (at Lessee's sole cost and expense) 
with all Applicable Requirements (as defined in Paragraph 6.3). "REPORTABLE 
USE" shall mean (i) the installation or use of any above or below ground 
storage tank, (ii) the generation, possession, storage, use, transportation, 
or disposal of a Hazardous Substance that requires a permit from, or with 
respect to which a report, notice, registration or business plan is required 
to be filed with, any governmental authority, and (iii) the presence in, on 
or about the Premises of a Hazardous Substance with respect to which any 
Applicable Laws require that a notice be given to persons entering or 
occupying the Premises or neighboring properties.  Notwithstanding the 
foregoing, Lessee may, without Lessor's prior consent, but upon notice to 
Lessor and in compliance with all Applicable Requirements, use any ordinary 
and customary materials reasonably required to be used by Lessee in the 
normal course of the Permitted Use, so long as such use is not a Reportable 
Use and does not expose the Premises or neighboring properties to any 
meaningful risk of contamination or damage or expose Lessor to any liability 
therefor.  In addition, Lessor may (but without any obligation to do so) 
condition its consent to any Reportable Use of any Hazardous Substance by 
Lessee upon Lessee's giving Lessor such additional assurances as Lessor, in 
its reasonable discretion, deems necessary to protect itself, the public, the 
Premises and the environment against damage, contamination or injury and/or 
liability therefor, including but not limited to the installation (and, at 
Lessor's option, removal on or before Lease expiration or earlier 
termination) at reasonably necessary protective modifications to the Premises 
(such as concrete encasements) and/or the deposit of an additional Security 
Deposit under Paragraph 5 hereof.

         (b)  DUTY TO INFORM LESSOR.  If Lessee knows, or has reasonable 
cause to believe, that a Hazardous Substance has come to be located in, on, 
under or about the Premises or the Building, other than as previously 
consented to by Lessor, Lessee shall immediately give Lessor written notice 
thereof, together with a copy of any statement, report notice, registration, 
application, permit, business plan, license, claim, action, or proceeding 
given to, or received from, any governmental authority or private party 
concerning the presence, spill, release, discharge of, or exposure to, such 
Hazardous Substance including but not limited to all such documents as may be 
involved in any Reportable Use involving the Premises. Lessee shall not cause 
or permit any Hazardous Substance to be spilled or released in, on, under or 
about the Premises (including, without limitation, through the plumbing or 
sanitary sewer system).

         (c)  INDEMNIFICATION.  Lessee shall indemnify, protect, defend and 
hold Lessor, its agents, employees, lenders and ground lessor, if any, and 
the Premises, harmless from and against any and all damages, liabilities, 
judgments, costs, claims, liens, expenses, penalties, loss of permits and 
attorneys' and consultants' fees arising out of or involving any Hazardous 
Substance brought onto the Premises by or for Lessee or by anyone under 
Lessee's control.  Lessee's obligations under this Paragraph 6.2(c) shall 
include, but not be limited to, the effects of any contamination or injury to 
person, property or the environment created or suffered by Lessee, and the 
cost of investigation (including consultants' and attorneys' fees and 
testing), removal, remediation, restoration and/or abatement thereof, or of 
any contamination therein involved, and shall survive the expiration or 
earlier termination of this Lease.  No termination, cancellation or release 
agreement entered into by 

                                      -3-

<PAGE>

Lessor and Lessee shall release Lessee from its obligations under this Lease 
with respect to Hazardous Substances, unless specifically so agreed by Lessor 
in writing at the time of such agreement.

    6.3  LESSEE'S COMPLIANCE WITH REQUIREMENTS.  Lessee shall, at Lessee's 
sole cost and expense, fully, diligently and in a timely manner, comply with 
all "APPLICABLE REQUIREMENTS," which term is used in this Lease to mean all 
laws, rules, regulations, ordinances, directives, covenants, easements and 
restrictions of record, permits, the requirements of any applicable fire 
insurance underwriter or rating bureau, and the recommendations of Lessor's 
engineers and/or consultants, relating in any manner to the Premises 
(including but not limited to matters pertaining to (i) industrial hygiene, 
(ii) environmental conditions on, in, under or about the Premises, including 
soil and groundwater conditions, and (iii) the use, generation, manufacture, 
production, installation, maintenance, removal, transportation, storage, 
spill, or release of any Hazardous Substance), now in effect or which may 
hereafter come into effect.  Lessee shall, within five (5) days after receipt 
of Lessor's written request, provide Lessor with copies of all documents and 
information, including but not limited to permits, registrations, manifests, 
applications, reports and certificates, evidencing Lessee's compliance with 
any Applicable Requirements specified by Lessor, and shall immediately upon 
receipt, notify Lessor in writing (with copies of any documents involved) of 
any threatened or actual claim, notice, citation, warning, complaint or 
report pertaining to or involving failure by Lessee or the Premises to comply 
with any Applicable Requirements.

    6.4  INSPECTION; COMPLIANCE WITH LAW.  Lessor, Lessor's agents, 
employees, contractors and designated representatives, and the holders of any 
mortgages, deeds of trust or ground leases on the Premises ("LENDERS") shall 
have the right to enter the Premises at any time in the case of an emergency, 
and otherwise at reasonable times, for the purpose of inspecting the 
condition of the Premises and for verifying compliance by Lessee with this 
Lease and all Applicable Requirements (as defined in Paragraph 6.3). and 
Lessor shall be entitled to employ experts and/or consultants in connection 
therewith to advise Lessor with respect to Lessee's activities, including but 
not limited to Lessee's installation, operation, use, monitoring, 
maintenance, or removal of any Hazardous Substance on or from the Premises.  
The costs and expenses of any such inspections shall be paid by the party 
requesting same, unless a Default or Breach of this Lease by Lessee or a 
violation of Applicable Requirements or a contamination, caused or materially 
contributed to by Lessee, is found to exist or to be imminent, or unless the 
inspection is requested or ordered by a governmental authority as the result 
of any such existing or imminent violation or contamination.  In such case, 
Lessee shall upon request reimburse Lessor or Lessor's Lender, as the case 
may be, for the costs and expenses of such inspections.

7.  MAINTENANCE, REPAIRS, UTILITY INSTALLATIONS, TRADE FIXTURES AND 
    ALTERATIONS.

    7.1  LESSEE'S OBLIGATIONS.

        (a)  Subject to the provisions of Paragraphs 2.2 (Condition), 2.3 
(Compliance with Covenants, Restrictions and Building Code), 7.2 (Lessor's 
Obligations), 9 (Damage or Destruction), and 14 (Condemnation), Lessee shall, 
at Lessee's sole cost and expense and at all times, keep the Premises and 
every part thereof in good order, condition and repair (whether or not such 
portion of the Premises requiring repair, or the means of repairing the same, 
are reasonably or readily accessible to Lessee, and whether or not the need 
for such repairs occurs as a result of Lessee's use, any prior use, the 
elements or the age of such portion of the Premises), including, without 
limiting the generality of the foregoing, all equipment or facilities 
specifically serving the Premises, such as plumbing, heating, air 
conditioning, ventilating, electrical, lighting facilities, boilers, fired or 
unfired pressure vessels, fire hose connections if within the Premises, 
fixtures, interior walls, interior surfaces of exterior walls, ceilings, 
floors, windows, doors, plate glass, and skylights, but excluding any items 
which are the responsibility of Lessor pursuant to Paragraph 7.2 below.  
Lessee, in keeping the Premises in good order, condition and repair, shall 
exercise and perform good maintenance practices.  Lessee's obligations shall 
include restorations, replacements or renewals when necessary to keep the 
Premises and all improvements thereon or a part thereof in good order, 
condition and state of repair.

         (b)  If Lessee fails to perform Lessee's obligations under this 
Paragraph 7.1, Lessor may enter upon the Premises after ten (10) days' prior 
written notice to Lessee (except in the case of an emergency, in which case 
no notice shall be required), perform such obligations on Lessee's behalf, 
and put the Premises in good order, condition and repair, in accordance with 
Paragraph 13.2 below.

    7.2  LESSOR'S OBLIGATIONS. Subject to the provisions of Paragraphs 2.2 
(Condition), 2.3 (Compliance with Covenants, Restrictions and Building Code), 
4.2 (Common Area Operating Expenses), 6 (Use), 7.1 (Lessee's Obligations), 9 
(Damage or Destruction) and 14 (Condemnation), Lessor, subject to 
reimbursement pursuant to Paragraph 4.2, shall keep in good order, condition 
and repair the foundations, exterior walls, structural condition of interior 
bearing walls, exterior roof, fire sprinkler and/or standpipe and hose (if 
located in the Common Areas) or other automatic fire extinguishing system 
including fire alarm and/or smoke detection systems and equipment, fire 
hydrants, parking lots, walkways, parkways, driveways, landscaping, fences, 
signs and utility systems serving the Common Areas and all parts thereof, as 
well as providing the services for which there is a Common Area Operating 
Expense pursuant to Paragraph 4.2. Lessor shall not be obligated to paint the 
exterior or interior surfaces of exterior walls nor shall Lessor be obligated 
to maintain, repair or replace windows, doors or plate glass of the Premises. 
Lessee expressly waives the benefit of any statute now or hereafter in 
effect which would otherwise afford Lessee the right to make repairs at 
Lessor's expense or to terminate this Lease because of Lessor's failure to 
keep the Building, Industrial Center or Common Areas in good order, condition 
and repair.

    7.3  UTILITY INSTALLATIONS, TRADE FIXTURES, ALTERATIONS.

         (a)  DEFINITIONS; CONSENT REQUIRED.  The term "UTILITY 
INSTALLATIONS" is used in this Lease to refer to all air lines, power panels, 
electrical distribution, security, fire protection systems, communications 
systems, lighting fixtures, heating, ventilating and air conditioning 
equipment, plumbing, and fencing in, on or about the Premises. The term 
"TRADE FIXTURES" shall mean Lessee's machinery and equipment which can be 
removed without doing material damage to the Premises.  The term 
"ALTERATIONS" shall mean any modification of the improvements on the Premises 
which are provided by Lessor under the terms of this Lease, other than 
Utility Installations or Trade Fixtures.  "LESSEE-OWNED ALTERATIONS AND/OR 
UTILITY INSTALLATIONS" are defined as Alterations and/or Utility 
Installations made by Lessee that are not yet owned by Lessor pursuant to 
Paragraph 7.4(a).  Lessee shall not make nor cause to be made any Alterations 
or Utility Installations in, on, under or about the Premises without Lessor's 
prior written consent.  Lessee may, however, make non-structural Utility 
Installations to the interior of the Premises (excluding the roof) without 
Lessor's consent but upon notice to Lessor, so long as they are not visible 
from the outside of the Premises, do not involve puncturing, relocating or 
removing the roof or any existing walls, or changing or interfering with the 
fire sprinkler or fire detection systems and the cumulative cost thereof 
during the term of this Lease as extended does not exceed $2,500.00.

         (b) CONSENT.  Any Alterations or Utility Installations that Lessee 
shall desire to make and which require the consent of the Lessor shall be 
presented to Lessor in written form with detailed plans.  All consents given 
by Lessor, whether by virtue of Paragraph 7.3(a) or by subsequent specific 
consent, shall be deemed conditioned upon: (i) Lessee's acquiring all 
applicable permits required by governmental authorities; (ii) the furnishing 
of copies of such permits together with a copy of the plans and 
specifications for the Alteration or Utility Installation to Lessor prior to 
commencement of the work thereon; and (iii) the compliance by Lessee with all 
conditions of said permits in a prompt and expeditious manner.  Any 
Alterations or Utility Installations by Lessee during the term of this Lease 
shall be done in a good and workmanlike manner, with good and sufficient 
materials, and be in compliance with all Applicable Requirements.  Lessee 
shall promptly upon completion thereof furnish Lessor with as-built plans and 
specifications therefor.  Lessor may, (but without obligation to do so) 
condition its consent to any requested Alteration or Utility Installation 
that costs $2,500.00 or more upon Lessee's providing Lessor with a lien and 
completion bond in an amount equal to one and one-half times the estimated 
cost of such Alteration or Utility Installation.

         (c) LIEN PROTECTION.  Lessee shall pay when due all claims for labor 
or materials furnished or alleged to have been furnished to or for Lessee at 
or for use on the Premises, which claims are or may be secured by any 
mechanic's or materialmen's lien against the Premises or any interest 
therein.  Lessee shall give Lessor not less than ten (10) days' notice prior 
to the commencement of any work in, on, or about the Premises, and Lessor 
shall have the right to post notices of non-responsibility in or on the 
Premises as provided by law.  If Lessee shall, in good faith, contest the 
validity of any such lien, claim or demand, then Lessee shall, at its sole 
expense, defend and protect itself, Lessor and the Premises against the same 
and shall pay and satisfy any such adverse judgment that may be rendered 
thereon before the enforcement thereof against the Lessor or the Premises.  
If Lessor shall require, Lessee shall furnish to Lessor a surety bond 
satisfactory to Lessor in an amount equal to one and one-half times the 
amount of such contested lien claim or demand, indemnifying Lessor against 
liability for the same, as required by law for the holding of the Premises 
free from the effect of such lien or claim.  In addition, Lessor may require 
Lessee to pay Lessor's attorneys' fees and costs in participating in such 
action if Lessor shall decide it is to its best interest to do so.

    7.4  OWNERSHIP, REMOVAL, SURRENDER, AND RESTORATION.

         (a) OWNERSHIP.  Subject to Lessor's right to require their removal 
and to cause Lessee to become the owner thereof as hereinafter provided in 
this Paragraph 7.4, all Alterations and Utility Installations made to the 
Premises by Lessee shall be the property of and owned by Lessee, but 
considered a part of the Premises.  Lessor may, at any time and at its 
option, elect in writing to Lessee to be the owner of all or any specified 
part of the Lessee-Owned Alterations and Utility

                                    -4-

<PAGE>

Installations. Unless otherwise instructed per Subparagraph 7.4(b) hereof, 
all Lessee-Owned Alterations and Utility Installations shall, at the 
expiration or earlier termination of this Lease, become the property of 
Lessor and remain upon the Premises and be surrendered with the Premises by 
Lessee.

         (b)  REMOVAL.  Unless otherwise agreed in writing, Lessor may 
require that any or all Lessee-Owned Alterations or Utility Installations be 
removed by the expiration or earlier termination of this Lease, 
notwithstanding that their installation may have been consented to by Lessor. 
 Lessor may require the removal at any time of all or any part of any 
Alterations or Utility Installations made without the required consent of 
Lessor.

         (c)  SURRENDER/RESTORATION.  Lessee shall surrender the Premises by 
the end of the last day of the Lease term or any earlier termination date, 
clean and free of debris and in good operating order, condition and state of 
repair, ordinary wear and tear excepted.  Ordinary wear and tear shall not 
include any damage or deterioration that would have been prevented by good 
maintenance practice or by Lessee performing all of its obligations under 
this Lease.  Except as otherwise agreed or specified herein, the Premises, as 
surrendered, shall include the Alterations and Utility Installations.  The 
obligation of Lessee shall include the repair of any damage occasioned by the 
installation, maintenance or removal of Lessee's Trade Fixtures, furnishings, 
equipment, and Lessee-Owned Alterations and Utility Installations, as well as 
the removal of any storage tank installed by or for Lessee, and the removal, 
replacement, or remediation of any soil, material or groundwater contaminated 
by Lessee, all as may then be required by Applicable Requirements and/or good 
practice.  Lessee's Trade Fixtures shall remain the property of Lessee and 
shall be removed by Lessee subject to its obligation to repair and restore 
the Premises per this Lease.

8.  INSURANCE; INDEMNITY.

    8.1  PAYMENT OF PREMIUMS.  The cost of the premiums for the insurance 
policies maintained by Lessor under this Paragraph 8 shall be a Common Area 
Operating Expense pursuant to Paragraph 4.2 hereof.  Premiums for policy 
periods commencing prior to, or extending beyond, the term of this Lease 
shall be prorated to coincide with the corresponding Commencement Date or 
Expiration Date.

    8.2  LIABILITY INSURANCE.

         (a) CARRIED BY LESSEE.  Lessee shall obtain and keep in force during 
the term of this Lease a Commercial General Liability policy of insurance 
protecting Lessee, Lessor and any Lender(s) whose names have been provided to 
Lessee in writing (as additional insureds) against claims for bodily injury, 
personal injury and property damage based upon, involving or arising out of 
the ownership, use, occupancy or maintenance of the Premises and all areas 
appurtenant thereto.  Such insurance shall be on an occurrence basis 
providing single limit coverage in an amount not less than $1,000,000 per 
occurrence with an "Additional Insured-Managers or Lessors of Premises" 
endorsement and contain the "Amendment of the Pollution Exclusion" 
endorsement for damage caused by heat, smoke or fumes from a hostile fire.  
The policy shall not contain any intra-insured exclusions as between insured 
persons or organizations, but shall include coverage for liability assumed 
under this Lease as an "insured contract" for the performance of Lessee's 
indemnity obligations under this Lease.  The limits of said insurance 
required by this Lease or as carried by Lessee shall not, however, limit the 
liability of Lessee nor relieve Lessee of any obligation hereunder.  All 
insurance to be carried by Lessee shall be primary to and not contributory 
with any similar insurance carried by Lessor, whose insurance shall be 
considered excess insurance only.

         (b) CARRIED BY LESSOR.  Lessor shall also maintain liability 
insurance described in Paragraph 8.2(a) above, in addition to and not in lieu 
of, the insurance required to be maintained by Lessee.  Lessee shall not be 
named as an additional insured therein. 

    8.3  PROPERTY INSURANCE - BUILDING, IMPROVEMENTS AND RENTAL VALUE.

         (a) BUILDING AND IMPROVEMENTS.  Lessor shall obtain and keep in 
force during the term of this Lease a policy or policies in the name of 
Lessor, with loss payable to Lessor and to any Lender(s), insuring against 
loss or damage to the Premises.  Such insurance shall be for full replacement 
cost, as the same shall exist from time to time, or the amount required by 
any Lender(s), but in no event more than the commercially reasonable and 
available insurable value thereof if, by reason of the unique nature or age 
of the improvements involved, such latter amount is less than full 
replacement cost.  Lessee-Owned Alterations and Utility Installations, Trade 
Fixtures and Lessee's personal property shall be insured by Lessee pursuant 
to Paragraph 8.4. If the coverage is available and commercially appropriate, 
Lessor's policy or policies shall insure against all risks of direct physical 
loss or damage, including coverage for any additional costs resulting from 
debris removal and reasonable amounts of coverage for the enforcement of any 
ordinance or law regulating the reconstruction or replacement of any 
undamaged sections of the Building required to be demolished or removed by 
reason of the enforcement of any building, zoning, safety or land use laws as 
the result of a covered loss, but not including plate glass insurance.  Said 
policy or policies shall also contain an agreed valuation provision in lieu 
of any co-insurance clause, waiver of subrogation, and inflation guard 
protection causing an increase in the annual property insurance coverage 
amount by a factor of not less than the adjusted U.S. Department of Labor 
Consumer Price Index for All Urban Consumers for the city nearest to where 
the Premises are located.

         (b) RENTAL VALUE.  Lessor shall also obtain and keep in force during 
the term of this Lease a policy or policies in the name of Lessor, with loss 
payable to Lessor and any Lender(s), insuring the loss of the full rental and 
other charges payable by all lessees of the Building to Lessor for one year 
(including all Real Property Taxes, insurance costs, all Common Area 
Operating Expenses and any scheduled rental increases). Said insurance may 
provide that in the event the Lease is terminated by reason of an insured 
loss, the period of indemnity for such coverage shall be extended beyond the 
date of the completion of repairs or replacement of the Premises, to provide 
for one full year's loss of rental revenues from the date of any such loss.  
Said insurance shall contain an agreed valuation provision in lieu of any 
co-insurance clause, and the amount of coverage shall be adjusted annually to 
reflect the projected rental income, Real Property Taxes, insurance premium 
costs and other expenses, if any, otherwise payable, for the next 12-month 
period.  Common Area Operating Expenses shall include any deductible amount 
in the event of such loss.

         (c) ADJACENT PREMISES.  Lessee shall pay for any increase in the 
premiums for the property insurance of the Building and for the Common Areas 
or other buildings in the Industrial Center it said increase is caused by 
Lessee's acts, omissions, use or occupancy of the Premises.

         (d) LESSEE'S IMPROVEMENTS.  Since Lessor is the Insuring Party, 
Lessor shall not be required to insure Lessee-Owned Alterations and Utility 
Installations unless the item in question has become the property of Lessor 
under the terms of this Lease.

    8.4  LESSEE'S PROPERTY INSURANCE.  Subject to the requirements of 
Paragraph 8.5, Lessee at its cost shall either by separate policy or, at 
Lessor's option, by endorsement to a policy already carried, maintain 
insurance coverage on all of Lessee's personal property, Trade Fixtures and 
Lessee-Owned Alterations and Utility Installations in, on, or about the 
Premises similar in coverage to that carried by Lessor as the Insuring Party 
under Paragraph 8.3(a).  Such insurance shall be full replacement cost 
coverage.  The proceeds from any such insurance shall be used by Lessee for 
the replacement of personal property and the restoration of Trade Fixtures 
and Lessee-Owned Alterations and Utility Installations. Upon request from 
Lessor, Lessee shall provide Lessor with written evidence that such insurance 
is in force.

    8.5  INSURANCE POLICIES.  Insurance required hereunder shall be in 
companies duly licensed to transact business in the state where the Premises 
are located, and maintaining during the policy term a "General Policyholders 
Rating" of at least B+, V, or such other rating as may be required by a 
Lender, as set forth in the most current issue of "Best's Insurance Guide." 
Lessee shall not do or permit to be done anything which shall invalidate the 
insurance policies referred to in this Paragraph 8. Lessee shall cause to be 
delivered to Lessor, within seven (7) days after the earlier of the Early 
Possession Date or the Commencement Date, certified copies of, or 
certificates evidencing the existence and amounts of, the insurance required 
under Paragraph 8.2(a) and 8.4.  No such policy shall be cancelable or the 
coverage thereunder reduced except after thirty (30) days' prior written 
notice to Lessor.  Lessee shall at least thirty (30) days prior to the 
expiration of such policies, furnish Lessor with evidence of renewals or 
"insurance binders" evidencing renewal thereof, or Lessor may order such 
insurance and charge the cost thereof to Lessee, which amount shall be 
payable by Lessee to Lessor upon demand.

    8.6  WAIVER OF SUBROGATION.  Without affecting any other rights or 
remedies, Lessee and Lessor each hereby release and relieve the other, and 
waive their entire right to recover damages (whether in contract or in tort) 
against the other, for loss or damage to their property arising out of or 
incident to the perils required to be insured against under Paragraph 8. The 
effect of such releases and waivers of the right to recover damages shall not 
be limited by the amount of insurance carried or required, or by any 
deductibles applicable thereto.  Lessor and Lessee agree to have their 
respective insurance companies issuing property damage insurance waive any 
right to subrogation that such companies may have against Lessor or Lessee, 
as the case may be, so long as the insurance is not invalidated thereby.

    8.7  INDEMNITY.  Except for Lessor's negligence and/or breach of express 
warranties, Lessee shall indemnify, protect, defend and hold harmless the 
Premises, Lessor and its agents, Lessor's master or ground lessor, partners 
and Lenders, from and against any and all claims, loss of rents and/or 
damages, costs, liens, judgments, penalties, loss of permits, attorneys' and 
consultants' fees, expenses and/or liabilities arising out of, involving, or 
in connection with, the occupancy of the Premises by Lessee, the conduct of 
Lessee's business, any act, omission or neglect of Lessee, its agents, 
contractors, employees or invites, and out of any Default or Breach 

                                    -5-

<PAGE>

by Lessee in the performance in a timely manner of any obligation on Lessee's 
part to be performed under this Lease.  The foregoing shall include, but not 
be limited to, the defense or pursuit of any claim or any action or 
proceeding involved therein, and whether or not (in the case of claims made 
against Lessor) litigated and/or reduced to judgment.  In case any action or 
proceeding be brought against Lessor by reason at any of the foregoing 
matters, Lessee upon notice from Lessor shall defend the same at Lessee's 
expense by counsel reasonably satisfactory to Lessor and Lessor shall 
cooperate with Lessee in such defense.  Lessor need not have first paid any 
such claim in order to be so indemnified.

    8.8  EXEMPTION OF LESSOR FROM LIABILITY.  Lessor shall not be liable for 
injury or damage to the person or goods, wares, merchandise or other property 
of Lessee, Lessee's employees, contractors, invites, customers, or any other 
person in or about the Premises, whether such damage or injury is caused by 
or results from fire, steam, electricity, gas, water or rain, or from the 
breakage, leakage, obstruction or other defects of pipes, fire sprinklers, 
wires, appliances, plumbing, air conditioning or lighting fixtures, or from 
any other cause, whether said injury or damage results from conditions 
arising upon the Premises or upon other portions of the Building of which the 
Premises are a part, from other sources or places, and regardless of whether 
the cause of such damage or injury or the means of repairing the same is 
accessible or not.  Lessor shall not be liable for any damages arising from 
any act or neglect of any other lessee of Lessor nor from the failure by 
Lessor to enforce the provisions of any other lease in the Industrial Center. 
 Notwithstanding Lessor's negligence or breach of this Lease, Lessor shall 
under no circumstances be liable for injury to Lessee's business or for any 
loss of income or profit therefrom.

9.  DAMAGE OR DESTRUCTION.

    9.1  DEFINITIONS.

         (a)  "PREMISES PARTIAL DAMAGE" shall mean damage or destruction to 
the Premises, other than Lessee-Owned Alterations and Utility Installations, 
the repair cost of which damage or destruction is less than fifty percent 
(50%) of the then Replacement Cost (as defined in Paragraph 9.1(d)) of the 
Premises (excluding Lessee-Owned Alterations and Utility Installations and 
Trade Fixtures) immediately prior to such damage or destruction.

         (b)  "PREMISES TOTAL DESTRUCTION" shall mean damage or destruction 
to the Premises, other than Lessee-Owned Alterations and Utility 
Installations, the repair cost of which damage or destruction is fifty 
percent (50%) or more of the then Replacement Cost of the Premises (excluding 
Lessee-Owned Alterations and Utility Installations and Trade Fixtures) 
immediately prior to such damage or destruction.  In addition, damage or 
destruction to the Building, other than Lessee-Owned Alterations and Utility 
Installations and Trade Fixtures of any lessees of the Building, the cost of 
which damage or destruction is fifty percent (50%) or more of the then 
Replacement Cost (excluding Lessee-Owned Alterations and Utility 
Installations and Trade Fixtures of any lessees of the Building) of the 
Building shall, at the option of Lessor, be deemed to be Premises Total 
Destruction.

         (c)  "INSURED LOSS" shall mean damage or destruction to the 
Premises, other than Lessee-Owned Alterations and Utility Installations and 
Trade Fixtures, which was caused by an event required to be covered by the 
insurance described in Paragraph 8.3(a) irrespective of any deductible 
amounts or coverage limits involved.

         (d)  "REPLACEMENT COST" shall mean the cost to repair or rebuild the 
improvements owned by Lessor at the time of the occurrence to their condition 
existing immediately prior thereto, including demolition, debris removal and 
upgrading required by the operation of applicable building codes, ordinances 
or laws, and without deduction for depreciation.

         (e)  "HAZARDOUS SUBSTANCE CONDITION" shall mean the occurrence or 
discovery of a condition involving the presence of, or a contamination by, a 
Hazardous Substance as defined in Paragraph 6.2(a), in, on, or under the 
Premises.

    9.2 PREMISES PARTIAL DAMAGE - INSURED LOSS.  If Premises Partial Damage 
that is an Insured Loss occurs, then Lessor shall, at Lessor's expense, 
repair such damage (but not Lessee's Trade Fixtures or Lessee-Owned 
Alterations and Utility Installations) as soon as reasonably possible and 
this Lease shall continue in full force and effect.  In the event, however, 
that there is a shortage of insurance proceeds and such shortage is due to 
the fact that, by reason of the unique nature of the improvements in the 
Premises, full replacement cost insurance coverage was not commercially 
reasonable and available, Lessor shall have no obligation to pay for the 
shortage in insurance proceeds or to fully restore the unique aspects of the 
Premises unless Lessee provides Lessor with the funds to cover same, or 
adequate assurance thereof, within ten (10) days following receipt of written 
notice of such shortage and request therefor.  It Lessor receives said funds 
or adequate assurance thereof within said ten (10) day period, Lessor shall 
complete them as soon as reasonably possible and this Lease shall remain in 
full force and effect.  If Lessor does not receive such funds or assurance 
within said period, Lessor may nevertheless elect by written notice to Lessee 
within ten (10) days thereafter to make such restoration and repair as is 
commercially reasonable with Lessor paying any shortage in proceeds, in which 
case this Lease shall remain in full force and effect.  If Lessor does not 
receive such funds or assurance within such ten (10) day period, and if 
Lessor does not so elect to restore and repair, then this Lease shall 
terminate sixty (60) days following the occurrence of the damage or 
destruction.  Unless otherwise agreed, Lessee shall in no event have any 
right to reimbursement from Lessor for any funds contributed by Lessee to 
repair any such damage or destruction.  Premises Partial Damage due to flood 
or earthquake shall be subject to Paragraph 9.3 rather than Paragraph 9.2, 
notwithstanding that there may be some insurance coverage, but the net 
proceeds of any such insurance shall be made available for the repairs if 
made by either Party.

    9.3  PARTIAL DAMAGE - UNINSURED LOSS.  If Premises Partial Damage that is 
not an Insured Loss occurs, unless caused by a negligent or willful act of 
Lessee (in which event Lessee shall make the repairs at Lessee's expense and 
this Lease shall continue in full force and effect), Lessor may at Lessor's 
option, either (i) repair such damage as soon as reasonably possible at 
Lessor's expense, in which event this Lease shall continue in full force and 
effect, or (ii) give written notice to Lessee within thirty (30) days after 
receipt by Lessor of knowledge of the occurrence of such damage of Lessor's 
desire to terminate this Lease as of the date sixty (60) days following the 
date of such notice.  In the event Lessor elects to give such notice of 
Lessor's intention to terminate this Lease, Lessee shall have the right 
within ten (10) days after the receipt of such notice to give written notice 
to Lessor of Lessee's commitment to pay for the repair of such damage totally 
at Lessee's expense and without reimbursement from Lessor.  Lessee shall 
provide Lessor with the required funds or satisfactory assurance thereof 
within thirty (30) days following such commitment from Lessee.  In such event 
this Lease shall continue in full force and effect, and Lessor shall proceed 
to make such repairs as soon as reasonably possible after the required funds 
are available.  If Lessee does not give such notice and provide the funds or 
assurance thereof within the times specified above, this Lease shall 
terminate as of the date specified in Lessor's notice of termination.

    9.4  TOTAL DESTRUCTION.  Notwithstanding any other provision hereof, if 
Premises Total Destruction occurs (including any destruction required by any 
authorized public authority), this Lease shall terminate sixty (60) days 
following the date of such Premises Total Destruction, whether or not the 
damage or destruction is an Insured Loss or was caused by a negligent or 
willful act of Lessee.  In the event, however, that the damage or destruction 
was caused by Lessee, Lessor shall have the right to recover Lessor's damages 
from Lessee except as released and waived in Paragraph 8.6.

    9.5  DAMAGE NEAR END OF TERM.  If at any time during the last six (6) 
months of the term of this Lease there is damage for which the cost to repair 
exceeds one month's Base Rent, whether or not an Insured Loss, Lessor may, at 
Lessor's option, terminate this Lease effective sixty (60) days following the 
date of occurrence of such damage by giving written notice to Lessee of 
Lessor's election to do so within thirty (30) days after the date of 
occurrence of such damage.  Provided, however, if Lessee at that time has an 
exercisable option to extend this Lease or to purchase the Premises, then 
Lessee may preserve this Lease by (a) exercising such option, and (b) 
providing Lessor with any shortage in insurance proceeds (or adequate 
assurance thereof) needed to make the repairs on or before the earlier of (i) 
the date which is ten (10) days after Lessee's receipt of Lessor's written 
notice purporting to terminate this Lease, or (ii) the day prior to the date 
upon which such option expires.  If Lessee duly exercises such option during 
such period and provides Lessor with funds (or adequate assurance thereof) to 
cover any shortage in insurance proceeds, Lessor shall, at Lessor's expense 
repair such damage as soon as reasonably possible and this Lease shall 
continue in full force and effect.  If Lessee fails to exercise such option 
and provide such funds or assurance during such period, then this Lease shall 
terminate as of the date set forth in the first sentence of this Paragraph 
9.5.

    9.6  ABATEMENT OF RENT; LESSEE'S REMEDIES.

         (a)  In the event of (i) Premises Partial Damage or (ii) Hazardous 
Substance Condition for which Lessee is not legally responsible, the Base 
Rent, Common Area Operating Expenses and other charges, if any, payable by 
Lessee hereunder for the period during which such damage or condition, its 
repair, remediation or restoration continues, shall be abated in proportion 
to the degree to which Lessee's use of the Premises is impaired, but not in 
excess of proceeds from insurance required to be carried under Paragraph 
8.3(b).  Except for abatement of Base Rent, Common Area Operating Expenses 
and other charges, it any, as aforesaid, all other obligations of Lessee 
hereunder shall be performed by Lessee, and Lessee shall have no claim 
against Lessor for any damage suffered by reason of any such damage, 
destruction, repair, remediation or restoration.

                                    -6-

<PAGE>

         (b)  If Lessor shall be obligated to repair or restore the Premises 
under the provisions of this Paragraph 9 and shall not commence, in a 
substantial and meaningful way, the repair or restoration of the Premises 
within ninety (90) days after such obligation shall accrue, Lessee may, at 
any time prior to the commencement of such repair or restoration, give 
written notice to Lessor and to any Lenders of which Lessee has actual notice 
of Lessees election to terminate this Lease on a date not less than sixty 
(60) days following the giving of such notice.  It Lessee gives such notice 
to Lessor and such Lenders and such repair or restoration is not commenced 
within thirty (30) days after receipt of such notice, this Lease shall 
terminate as of the date specified in said notice.  If Lessor or a Lender 
commences the repair or restoration of the Premises within thirty (30) days 
after the receipt of such notice, this Lease shall continue in full force and 
effect.  "COMMENCE" as used in this Paragraph 9.6 shall mean either the 
unconditional authorization of the preparation of the required plans, or the 
beginning of the actual work on the Premises, whichever occurs first.

    9.7  HAZARDOUS SUBSTANCE CONDITIONS.  If a Hazardous Substance Condition 
occurs, unless Lessee is legally responsible therefor (in which case Lessee 
shall make the investigation and remediation thereof required by Applicable 
Requirements and this Lease shall continue in full force and effect, but 
subject to Lessor's rights under Paragraph 6.2(c) and Paragraph 13), Lessor 
may at Lessor's option either (i) investigate and remediate such Hazardous 
Substance Condition, if required, as soon as reasonably possible at Lessor's 
expense, in which event this Lease shall continue in full force and effect, 
or (ii) if the estimated cost to investigate and remediate such condition 
exceeds twelve (12) times the then monthly Bass Rent or $100,000, whichever 
is greater, give written notice to Lessee within thirty (30) days after 
receipt by Lessor of knowledge of the occurrence of such Hazardous Substance 
Condition of Lessor's desire to terminate this Lease as of the date sixty 
(60) days following the date of such notice.  In the event Lessor elects to 
give such notice of Lessor's intention to terminate this Lease, Lessee shall 
have the right within ten (10) days after the receipt of such notice to give 
written notice to Lessor of Lessee's commitment to pay for the excess costs 
of (a) investigation and remediation of such Hazardous Substance Condition to 
the extent required by Applicable Requirements, over (b) an amount equal to 
twelve (12) times the then monthly Base Rent or $100,000, whichever is 
greater.  Lessee shall provide Lessor with the funds required of Lessee or 
satisfactory assurance thereof within thirty (30) days following said 
commitment by Lessee.  In such event this Lease shall continue in full force 
and effect, and Lessor shall proceed to make such investigation and 
remediation as soon as reasonably possible after the required funds are 
available.  If Lessee does not give such notice and provide the required 
funds or assurance thereof within the time period specified above, this Lease 
shall terminate as of the date specified in Lessor's notice of termination.

    9.8  TERMINATION - ADVANCE PAYMENTS.  Upon termination of this Lease 
pursuant to this Paragraph 9, Lessor shall return to Lessee any advance 
payment made by Lessee to Lessor and so much of Lessee's Security Deposit as 
has not been, or is not then required to be, used by Lessor under the terms 
of this Lease.

    9.9  WAIVER OF STATUTES.  Lessor and Lessee agree that the terms of this 
Lease shall govern the effect of any damage to or destruction of the Premises 
and the Building with respect to the termination of this Lease and hereby 
waive the provisions of any present or future statute to the extent it is 
inconsistent herewith.

10. REAL PROPERTY TAXES.

    10.1  PAYMENT OF TAXES.  Lessor shall pay the Real Property Taxes, as 
defined in Paragraph 10.2, applicable to the Industrial Center, and except as 
otherwise provided in Paragraph 10.3, any such amounts shall be included in 
the calculation of Common Area Operating Expenses in accordance with the 
provisions of Paragraph 4.2.

    10.2  REAL PROPERTY TAX DEFINITION.  As used herein, the term "REAL 
PROPERTY TAXES" shall include any form of real estate tax or assessment, 
general, special, ordinary or extraordinary, and any license fee, commercial 
rental tax, improvement bond or bonds, levy or tax (other than inheritance, 
personal income or estate taxes) imposed upon the Industrial Center by any 
authority having the direct or indirect power to tax, including any city, 
state or federal government, or any school, agricultural, sanitary, fire, 
street, drainage, or other improvement district thereof, levied against any 
legal or equitable interest of Lessor in the Industrial Center or any portion 
thereof, Lessor's right to rent or other income therefrom, and/or Lessor's 
business of leasing the Premises. The term "REAL PROPERTY TAXES" shall also 
include any tax, fee, levy, assessment or charge, or any increase therein, 
imposed by reason of events occurring, or changes in Applicable Law taking 
effect, during the term of this Lease, including but not limited to a change 
in the ownership of the Industrial Center or in the improvements thereon, the 
execution of this Lease, or any modification, amendment or transfer thereof, 
and whether or not contemplated by the Parties.  In calculating Real Property 
Taxes for any calendar year, the Real Property Taxes for any real estate tax 
year shall be included in the calculation of Real Property Taxes for such 
calendar year based upon the number of days which such calendar year and tax 
year have in common.

    10.3  ADDITIONAL IMPROVEMENTS.  Common Area Operating Expenses shall not 
include Real Property Taxes specified in the tax assessor's records and work 
sheets as being caused by additional improvements placed upon the Industrial 
Center by other lessees or by Lessor for the exclusive enjoyment of such 
other lessees.  Notwithstanding Paragraph 10.1 hereof, Lessee shall, however, 
pay to Lessor at the time Common Area Operating Expenses are payable under 
Paragraph 4.2, the entirety of any increase in Real Property Taxes if 
assessed solely by reason of Alterations, Trade Fixtures or Utility 
Installations placed upon the Premises by Lessee or at Lessee's request.

    10.4  JOINT ASSESSMENT.  If the Building is not separately assessed, Real 
Property Taxes allocated to the Building shall be an equitable proportion of 
the Real Property Taxes for all of the land and improvements included within 
the tax parcel assessed, such proportion to be determined by Lessor from the 
respective valuations assigned in the assessor's work sheets or such other 
information as may be reasonably available.  Lessor's reasonable 
determination thereof, in good faith, shall be conclusive.

    10.5  LESSEE'S PROPERTY TAXES.  Lessee shall pay prior to delinquency all 
taxes assessed against and levied upon Lessee-Owned Alterations and Utility 
Installations, Trade Fixtures, furnishings, equipment and all personal 
property of Lessee contained in the Premises or stored within the Industrial 
Center.  When possible, Lessee shall cause its Lessee-Owned Alterations and 
Utility Installations, Trade Fixtures, furnishings, equipment and all other 
personal property to be assessed and billed separately from the real property 
of Lessor.  If any of Lessee's said property shall be assessed with Lessor's 
real property, Lessee shall pay Lessor the taxes attributable to Lessee's 
property within ten (10) days after receipt of a written statement setting 
forth the taxes applicable to Lessee's property.

11. UTILITIES.  Lessee shall pay directly for all utilities and services 
supplied to the Premises, including but not limited to electricity, 
telephone, security, gas and cleaning of the Premises, together with any 
taxes thereon.  If any such utilities or services are not separately metered 
to the Premises or separately billed to the Premises, Lessee shall pay to 
Lessor a reasonable proportion to be determined by Lessor of all such charges 
jointly metered or billed with other premises in the Building, in the manner 
and within the time periods set forth in Paragraph 4.2(d).

12. ASSIGNMENT AND SUBLETTING.

    12.1 LESSOR'S CONSENT REQUIRED.

         (a)  Lessee shall not voluntarily or by operation of law assign, 
transfer, mortgage or otherwise transfer or encumber (collectively, "assign") 
 or  sublet all or any part of Lessee's interest in this Lease or in the 
Premises without Lessor's prior written consent given under and subject to 
the terms of Paragraph 36.

         (b)  A change in the control of Lessee shall constitute an 
assignment requiring Lessor's consent.  The transfer, on a cumulative basis, 
of fifty percent (50%) or more of the voting control of Lessee shall 
constitute a change in control for this purpose.

         (c)  The involvement of Lessee or its assets in any transaction, or 
series of transactions (by way of merger, sale, acquisition, financing, 
refinancing, transfer, leveraged buy-out or otherwise), whether or not a 
formal assignment or hypothecation of this Lease or Lessee's assets occurs, 
which results or will result in a reduction of the Net Worth of Lessee, as 
hereinafter defined, by an amount equal to or greater than twenty-five 
percent (25%) of such Net Worth of Lessee as it was represented to Lessor at 
the time of full execution and delivery of this Lease or at the time of the 
most recent assignment to which Lessor has consented, or as it exists 
immediately prior to said transaction or transactions constituting such 
reduction, at whichever time said Net Worth of Lessee was or is greater, 
shall be considered an assignment of this Lease by Lessee to which Lessor may 
reasonably withhold its consent.  "NET WORTH OF LESSEE" for purposes of this 
Lease shall be the net worth of Lessee (excluding any Guarantors) established 
under generally accepted accounting principles consistently applied.

         (d)  An assignment or subletting of Lessee's interest in this Lease 
without Lessor's specific prior written consent shall, at Lessor's option, be 
a Default curable after notice per Paragraph 13.1, or a non-curable Breach 
without the necessity of any notice and grace period.  If Lessor elects to 
treat such unconsented to assignment or subletting as a non-curable Breach, 
Lessor shall have the right to either: (i) terminate this Lease, or (ii) upon 
thirty (30) days' written notice ("Lessor's Notice"), increase the monthly 
Base Rent for the Premises to the greater of the then fair market rental 
value of the Premises, as reasonably determined by Lessor, or one hundred ten 
percent (110%) of the Base Rent then in effect.  Pending determination of the 
new fair market rental value, if disputed by Lessee, Lessee shall 

                                   -7-

<PAGE>

pay the amount set forth in Lessor's Notice, with any overpayment credited 
against the next installment(s) of Base Rent coming due, and any underpayment 
for the period retroactively to the effective date of the adjustment being 
due and payable immediately upon the determination thereof.  Further, in the 
event of such Breach and rental adjustment, (i) the purchase price of any 
option to purchase the Premises held by Lessee shall be subject to similar 
adjustment to the then fair market value as reasonably determined by Lessor 
(without the Lease being considered an encumbrance or any deduction for 
depreciation or obsolescence, and considering the Premises at its highest and 
best use and in good condition) or one hundred ten percent (110%) of the 
price previously in effect, (ii) any index-oriented rental or price 
adjustment formulas contained in this Lease shall be adjusted to require that 
the base index be determined with reference to the index applicable to the 
time of such adjustment, and (iii) any fixed rental adjustments scheduled 
during the remainder of the Lease term shall be increased in the same ratio 
as the new rental bears to the Base Rent in effect immediately prior to the 
adjustment specified in Lessor's Notice.

         (e)  Lessee's remedy for any breach of this Paragraph 12.1 by Lessor 
shall be limited to compensatory damages and/or injunctive relief.

    12.2  TERMS AND CONDITIONS APPLICABLE TO ASSIGNMENT AND SUBLETTING.

          (a)  Regardless of Lessor's consent, any assignment or subletting 
shall not (i) be effective without the express written assumption by such 
assignee or sublessee of the obligations of Lessee under this Lease, (ii) 
release Lessee of any obligations hereunder, nor (iii) after the primary 
liability of Lessee for the payment of Base Rent and other sums due Lessor 
hereunder or for the performance of any other obligations to be performed by 
Lessee under this Lease.

          (b)  Lessor may accept any rent or performance of Lessee's 
obligations from any person other than Lessee pending approval or disapproval 
of an assignment.  Neither a delay in the approval or disapproval of such 
assignment nor the acceptance of any rent for performance shall constitute a 
waiver or estoppel of Lessor's right to exercise its remedies for the Default 
or Breach by Lessee of any of the terms, covenants or conditions of this 
Lease.

          (c)  The consent of Lessor to any assignment or subletting shall 
not constitute a consent to any subsequent assignment or subletting by Lessee 
or to any subsequent or successive assignment or subletting by the assignee 
or sublessee.  However, Lessor may consent to subsequent sublettings and 
assignments of the sublease or any amendments or modifications thereto 
without notifying Lessee or anyone else liable under this Lease or the 
sublease and without obtaining their consent, and such action shall not 
relieve such persons from liability under this Lease or the sublease.

          (d)  In the event of any Default or Breach of Lessee's obligation 
under this Lease, Lessor may proceed directly against Lessee, any Guarantors 
or anyone else responsible for the performance of the Lessee's obligations 
under this Lease, including any sublessee, without first exhausting Lessor's 
remedies against any other person or entity responsible therefor to Lessor, 
or any security held by Lessor.

          (e)  Each request for consent to an assignment or subletting shall 
be in writing, accompanied by information relevant to Lessor's determination 
as to the financial and operational responsibility and appropriateness of the 
proposed assignee or sublessee, including but not limited to the intended use 
and/or required modification of the Premises, if any, together with a 
non-refundable deposit of $1,000 or ten percent (10%) of the monthly Base 
Rent applicable to the portion of the Premises which is the subject of the 
proposed assignment or sublease, whichever is greater, as reasonable 
consideration for Lessor's considering and processing the request for 
consent.  Lessee agrees to provide Lessor with such other or additional 
information and/or documentation as may be reasonably requested by Lessor.

          (f)  Any assignee of, or sublessee under, this Lease shall, by 
reason of accepting such assignment or entering into such sublease, be 
deemed, for the benefit of Lessor, to have assumed and agreed to conform and 
comply with each and every term, covenant, condition and obligation herein to 
be observed or performed by Lessee during the term of said assignment or 
sublease, other than such obligations as are contrary to or inconsistent with 
provisions of an assignment or sublease to which Lessor has specifically 
consented in writing.

          (g)  The occurrence of a transaction described in Paragraph 12.2(c) 
shall give Lessor the right (but not the obligation) to require that the 
Security Deposit be increased by an amount equal to six (6) times the then 
monthly Bass Rent, and Lessor may make the actual receipt by Lessor of the 
Security Deposit increase a condition to Lessor's consent to such transaction.

          (h)  Lessor, as a condition to giving its consent to any assignment 
or subletting, may require that the amount and adjustment schedule of the 
rent payable under this Lease be adjusted to what is then the market value 
and/or adjustment schedule for property similar to the Premises as then 
constituted, as determined by Lessor.

    12.3  ADDITIONAL TERMS AND CONDITIONS APPLICABLE TO SUBLETTING.  The 
following terms and conditions shall apply to any subletting by Lessee of all 
or any part of the Premises and shall be deemed included in all subleases 
under this Lease whether or not expressly incorporated therein:

          (a)  Lessee hereby assigns and transfers to Lessor all of Lessee's 
interest in all rentals and income arising from any sublease of all or a 
portion of the Premises heretofore or hereafter made by Lessee, and Lessor 
may collect such rent and income and apply same toward Lessee's obligations 
under this Lease; provided, however, that until a Breach (as defined in 
Paragraph 13.1) shall occur in the performance of Lessee's obligations under 
this Lease, Lessee may, except as otherwise provided in this Lease, receive, 
collect and enjoy the rents accruing under such sublease.  Lessor shall not, 
by reason of the foregoing provision or any other assignment of such sublease 
to Lessor, nor by reason of the collection of the rents from a sublessee, be 
deemed liable to the sublessee for any failure of Lessee to perform and 
comply with any of Lessee's obligations to such sublessee under such 
Sublease.  Lessee hereby irrevocably authorizes and directs any such 
sublessee, upon receipt of a written notice from Lessor stating that a Breach 
exists in the performance of Lessee's obligations under this Lease, to pay to 
Lessor the rents and other charges due and to become due under the sublease.  
Sublessee shall rely upon any such statement and request from Lessor and 
shall pay such rents and other charges to Lessor without any obligation or 
right to inquire as to whether such Breach exists and notwithstanding any 
notice from or claim from Lessee to the contrary.  Lessee shall have no right 
or claim against such sublessee, or, until the Breach has been cured, against 
Lessor, for any such rents and other charges so paid by said sublessee to 
Lessor.

          (b)  In the event of a Breach by Lessee in the performance of its 
obligations under this Lease, Lessor, at its option and without any 
obligation to do so, may require any sublessee to attorn to Lessor, in which 
event Lessor shall undertake the obligations of the sublessor under such 
sublease from the time of the exercise of said option to the expiration of 
such sublease; provided, however, Lessor shall not be liable for any prepaid 
rents or security deposit paid by such sublessee to such sublessor or for any 
other prior defaults or breaches of such sublessor under such sublease.

          (c)  Any matter or thing requiring the consent of the sublessor 
under a sublease shall also require the consent of Lessor herein.

          (d)  No sublessee under a sublease approved by Lessor shall further 
assign or sublet all or any part of the Premises without Lessor's prior 
written consent.

          (e)  Lessor shall deliver a copy of any notice of Default or Breach 
by Lessee to the sublessee, who shall have the right to cure the Default of 
Lessee within the grace period, if any, specified in such notice.  The 
sublessee shall have a right of reimbursement and offset from and against 
Lessee for any such Defaults cured by the sublessee.

13. DEFAULT; BREACH; REMEDIES.

    13.1  DEFAULT; BREACH.  Lessor and Lessee agree that if an attorney is 
consulted by Lessor in connection with a Lessee Default or Breach (as 
hereinafter defined), $350.00 is a reasonable minimum sum per such occurrence 
for legal services and costs in the preparation and service of a notice of 
Default, and that Lessor may include the cost of such services and costs in 
said notice as rent due and payable to cure said default.  A "DEFAULT" by 
Lessee is defined as a failure by Lessee to observe, comply with or perform 
any of the terms, covenants, conditions or rules applicable to Lessee under 
this Lease.  A "BREACH" by Lessee is defined as the occurrence of any one or 
more of the following Defaults, and, where a grace period for cure after 
notice is specified herein, the failure by Lessee to cure such Default prior 
to the expiration of the applicable grace period, and shall entitle Lessor to 
pursue the remedies set forth in Paragraphs 13.2 and/or 13.3:

         (a)  The vacating of the Premises without the intention to reoccupy 
same, or the abandonment of the Premises.

         (b)  Except as expressly otherwise provided in this Lease, the 
failure by Lessee to make any payment of Base Rent, Lessee's Share of Common 
Area Operating Expenses, or any other monetary payment required to be made by 
Lessee hereunder as and when due, the failure by Lessee to provide Lessor 

                                   -8-

<PAGE>

with reasonable evidence of insurance or surety bond required under this 
Lease, or the failure of Lessee to fulfill any obligation under this Lease 
which endangers or threatens life or property, where such failure continues 
for a period of five (5) days following written notice thereof by or on 
behalf of Lessor to Lessee.

         (c)  Except as expressly otherwise provided in this Lease, the 
failure by Lessee to provide Lessor with reasonable written evidence (in duly 
executed original form, if applicable) of (i) compliance with Applicable 
Requirements per Paragraph 6.3, (ii) the inspection, maintenance and service 
contracts required under Paragraph 7.1(b), (iii) the rescission of an 
unauthorized assignment or subletting per Paragraph 12.1, (iv) a Tenancy 
Statement per Paragraphs 16 or 37, (v) the subordination or non-subordination 
of this Lease per Paragraph 30, (vi) the guaranty of the performance of 
Lessee's obligations under this Lease if required under Paragraphs 1.11 and 
37, (vii) the execution of any document requested under Paragraph 42 
(easements), or (viii) any other documentation or information which Lessor 
may reasonably require of Lessee under the terms of this lease, where any 
such failure continues for a period of ten (10) days following written notice 
by or on behalf of Lessor to Lessee.

         (d)  A Default by Lessee as to the terms, covenants, conditions or 
provisions of this Lease, or of the rules adopted under Paragraph 40 hereof 
that are to be observed, complied with or performed by Lessee, other than 
those described in Subparagraphs 13.1(a), (b) or (c), above, where such 
Default continues for a period of thirty (30) days after written notice 
thereof by or on behalf of Lessor to Lessee; provided, however, that if the 
nature of Lessee's Default is such that more than thirty (30) days are 
reasonably required for its cure, then it shall not be deemed to be a Breach 
of this Lease by Lessee if Lessee commences such cure within said thirty (30) 
day period and thereafter diligently prosecutes such cure to completion.

         (e)  The occurrence of any of the following events: (i) the making 
by Lessee of any general arrangement or assignment for the benefit of 
creditors; (ii) Lessee's becoming a "debtor" as defined in 11 U.S. Code 
Section 101 or any successor statute thereto (unless, in the case of a 
petition filed against Lessee, the same is dismissed within sixty (60) days); 
(iii) the appointment of a trustee or receiver to take possession of 
substantially all of Lessee's assets located at the Premises or of Lessee's 
interest in this Lease, where possession is not restored to Lessee within 
thirty (30) days; or (iv) the attachment, execution or other judicial seizure 
of substantially all of Lessee's assets located at the Premises or of 
Lessee's interest in this Lease, where such seizure is not discharged within 
thirty (30) days; provided, however, in the event that any provision of this 
Subparagraph 13.1(e) is contrary to any applicable law, such provision shall 
be of no force or effect, and shall not affect the validity of the remaining 
provisions.

         (f)  The discovery by Lessor that any financial statement of Lessee 
or of any Guarantor, given to Lessor by Lessee or any Guarantor, was 
materially false.

         (g)  If the performance of Lessee's obligations under this Lease is 
guaranteed: (i) the death of a Guarantor, (ii) the termination of a 
Guarantor's liability with respect to this Lease other than in accordance 
with the terms of such guaranty, (iii) a Guarantor's becoming insolvent or 
the subject of a bankruptcy filing, (iv) a Guarantor's refusal to honor the 
guaranty, or (v) a Guarantor's breach of its guaranty obligation on an 
anticipatory breach basis, and Lessee's failure, within sixty (60) days 
following written notice by or on behalf of Lessor to Lessee of any such 
event, to provide Lessor with written alternative assurances of security, 
which, when coupled with the then existing resources of Lessee, equals or 
exceeds the combined financial resources of Lessee and the Guarantors that 
existed at the time of execution of this Lease.

    13.2  REMEDIES.  If Lessee fails to perform any affirmative duty or 
obligation of Lessee under this Lease, within ten (10) days after written 
notice to Lessee (or in case of an emergency, without notice), Lessor may at 
its option (but without obligation to do so), perform such duty or obligation 
on Lessee's behalf, including but not limited to the obtaining of reasonably 
required bonds, insurance policies, or governmental licenses, permits or 
approvals.  The costs and expenses of any such performance by Lessor shall be 
due and payable by Lessee to Lessor upon invoice therefor. If any check given 
to Lessor by Lessee shall not be honored by the bank upon which it is drawn, 
Lessor, at its own option, may require all future payments to be made under 
this Lease by Lessee to be made only by cashier's check.  In the event of a 
Breach of this Lease by Lessee (as defined in Paragraph 13.11), with or 
without further notice or demand, and without limiting Lessor in the exercise 
of any right or remedy which Lessor may have by reason of such Breach, Lessor 
may:

         (a)  Terminate Lessee's right to possession of the Premises by any 
lawful means, in which case this Lease and the term hereof shall terminate 
and Lessee shall immediately surrender possession of the Premises to Lessor.  
In such event Lessor shall be entitled to recover from Lessee: (i) the worth 
at the time of the award of the unpaid rent which had been earned at the time 
of termination; (ii) the worth at the time of award of the amount by which 
the unpaid rent which would have been earned after termination until the time 
of award exceeds the amount of such rental loss that the Lessee proves could 
have been reasonably avoided; (iii) the worth at the time of award of the 
amount by which the unpaid rent for the balance of the term after the time of 
award exceeds the amount of such rental loss that the Lessee proves could be 
reasonably avoided; and (iv) any other amount necessary to compensate Lessor 
for all the detriment proximately caused by the Lessee's failure to perform 
its obligations under this Lease or which in the ordinary course of things 
would be likely to result therefrom, including but not limited to the cost of 
recovering possession of the Premises, expenses of reletting, including 
necessary renovation and alteration of the Premises, reasonable attorneys' 
fees, and that portion of any leasing commission paid by Lessor in connection 
with this Lease applicable to the unexpired term of this Lease.  The worth at 
the time of award of the amount referred to in provision (iii) of the 
immediately preceding sentence shall be computed by discounting such amount 
at the discount rate of the Federal Reserve Bank of San Francisco or the 
Federal Reserve Bank District in which the Premises are located at the time 
of award plus one percent (1%).  Efforts by Lessor to mitigate damages caused 
by Lessee's Default or Breach of this Lease shall not waive Lessor's right to 
recover damages under this Paragraph 13.2.  If termination of this Lease is 
obtained through the provisional remedy of unlawful detainer, Lessor shall 
have the right to recover in such proceeding the unpaid rent and damages as 
are recoverable therein, or Lessor may reserve the right to recover all or 
any part thereof in a separate suit for such rent and/or damages.  If a 
notice and grace period required under Subparagraph 13.1 (b), (c) or (d) was 
not previously given, a notice to pay rent or quit, or to perform or quit, as 
the case may be, given to Lessee under any statute authorizing the forfeiture 
of leases for unlawful detainer shall also constitute the applicable notice 
for grace period purposes required by Subparagraph 13.1(b), (c) or (d).  In 
such case, the applicable grace period under the unlawful detainer statue 
shall run concurrently after the one such statutory notice, and the failure 
of Lessee to cure the Default within the greater of the two (2) such grace 
periods shall constitute both an unlawful detainer and a Breach of this Lease 
entitling Lessor to the remedies provided for in this Lease and/or by said 
statute.

         (b)  Continue the Lease and Lessee's right to possession in effect 
(in California under California Civil Code Section 1951.4) after Lessee's 
Breach and recover the rent as it becomes due, provided Lessee has the right 
to sublet or assign, subject only to reasonable limitations. Lessor and 
Lessee agree that the limitations on assignment and subletting in this Lease 
are reasonable.  Acts of maintenance or preservation, efforts to relet the 
Premises, or the appointment of a receiver to protect the Lessor's interest 
under this Lease, shall not constitute a termination of the Lessee's right to 
possession.

         (c)  Pursue any other remedy now or hereafter available to Lessor 
under the laws or judicial decisions of the state wherein the Premises are 
located.

         (d)  The expiration or termination of this Lease and/or the 
termination of Lessee's right to possession shall not relieve Lessee from 
liability under any indemnity provisions of this Lease as to matters 
occurring or accruing during the term hereof or by reason of Lessee's 
occupancy of the Premises.

    13.3  INDUCEMENT RECAPTURE IN EVENT OF BREACH.  Any agreement by Lessor 
for free or abated rent or other charges applicable to the Premises, or for 
the giving or paying by Lessor to or for Lessee of any cash or other bonus, 
inducement or consideration for Lessee's entering into this Lease, all of 
which concessions are hereinafter referred to as "INDUCEMENT PROVISIONS" 
shall be deemed conditioned upon Lessee's full and faithful performance of 
all of the terms, covenants and conditions of this Lease to be performed or 
observed by Lessee during the term hereof as the same may be extended. Upon 
the occurrence of a Breach (as defined in Paragraph 13.1) of this Lease by 
Lessee, any such Inducement Provision shall automatically be deemed deleted 
from this Lease and of no further force or effect, and any rent, other 
charge, bonus. inducement or consideration theretofore abated, given or paid 
by Lessor under such an Inducement Provision shall be immediately due and 
payable by Lessee to Lessor, and recoverable by Lessor, as additional rent 
due under this Lease, notwithstanding any subsequent cure of said Breach by 
Lessee.  The acceptance by Lessor of rent or the cure of the Breach which 
initiated the operation of this Paragraph 13.3 shall not be deemed a waiver 
by Lessor of the provisions of this Paragraph 13.3 unless specifically so 
stated in writing by Lessor at the tine of such acceptance.

    13.4  LATE CHARGES.  Lessee hereby acknowledges that late payment by 
Lessee to Lessor of rent and other sums due hereunder will cause Lessor to 
incur costs not contemplated by this Lease, the exact amount of which will be 
extremely difficult to ascertain.  Such costs include, but are not limited 
to, processing and accounting charges, and late charges which may be imposed 
upon Lessor by the terms of any ground lease, mortgage or deed of trust 
covering the Premises.  Accordingly, if any installment of rent or other sum 
due from Lessee shall not be received by Lessor or Lessor's designee within 
ten (10) days after such amount shall be due, then, without any requirement 
for notice to Lessee, Lessee shall pay to Lessor a late charge equal to six 
percent (6%) of such overdue amount.  The parties hereby agree that such late 
charge represents a fair and reasonable estimate of the costs Lessor will 
incur by reason of late payment by Lessee.  Acceptance of such late charge by 
Lessor shall in no event constitute a waiver of Lessee's Default or Breach 
with respect to such overdue amount, nor prevent Lessor from exercising any 
of the other rights and 

                                   -9-

<PAGE>

remedies granted hereunder.  In the event that a late charge is payable 
hereunder, whether or not collected, for three (3) consecutive installments 
of Base Rent, then notwithstanding Paragraph 4.1 or any other provision of 
this Lease to the contrary, Base Rent shall, at Lessor's option, become due 
and payable quarterly in advance.

    13.5  BREACH BY LESSOR.  Lessor shall not be deemed in breach of this 
Lease unless Lessor fails within a reasonable time to perform an obligation 
required to be performed by Lessor.  For purposes of this Paragraph 13.5, a 
reasonable time shall in no event be less than thirty (30) days after receipt 
by Lessor, and by any Lender(s) whose name and address shall have been 
furnished to Lessee in writing for such purpose, of written notice specifying 
wherein such obligation of Lessor has not been performed; provided, however, 
that if the nature of Lessor's obligation is such that more than thirty (30) 
days after such notice are reasonably required for its performance, then 
Lessor shall not be in breach of this Lease if performance is commenced 
within such thirty (30) day period and thereafter diligently pursued to 
completion.

14. CONDEMNATION.  If the Premises or any portion thereof are taken under the 
power of eminent domain or sold under the threat of the exercise of said 
power (all of which are herein called "condemnation"), this Lease shall 
terminate as to the part so taken as of the date the condemning authority 
takes title or possession, whichever first occurs.  If more than ten percent 
(10%) of the floor area of the Premises, or more than twenty-five percent 
(25%) of the portion of the Common Areas designated for Lessee's parking, is 
taken by condemnation, Lessee may, at Lessee's option, to be exercised in 
writing within ten (10) days after Lessor shall have given Lessee written 
notice of such taking (or in the absence of such notice, within ten (10) days 
after the condemning authority shall have taken possession) terminate this 
Lease as of the date the condemning authority takes such possession.  If 
Lessee does not terminate this Lease in accordance with the foregoing, this 
Lease shall remain in full force and effect as to the portion of the Premises 
remaining, except that the Base Rent shall be reduced in the same proportion 
as the rentable floor area of the Premises taken bears to the total rentable 
floor area of the Premises. No reduction of Base Rent shall occur it the 
condemnation does not apply to any portion of the Premises.  Any award for 
the taking of all or any part of the Premises under the power of eminent 
domain or any payment made under threat of the exercise of such power shall 
be the property of Lessor, whether such award shall be made as compensation 
for diminution of value of the leasehold or for the taking of the fee, or as 
severance damages; provided, however, that Lessee shall be entitled to any 
compensation, separately awarded to Lessee for Lessee's relocation expenses 
and/or loss of Lessee's Trade Fixtures.  In the event that this Lease is not 
terminated by reason of such condemnation, Lessor shall to the extent of its 
net severance damages received, over and above Lessee's Share of the legal 
and other expenses incurred by Lessor in the condemnation matter, repair any 
damage to the Premises caused by such condemnation authority.  Lessee shall 
be responsible for the payment of any amount in excess of such net severance 
damages required to complete such repair.

15. BROKERS' FEES.

    15.1  REPRESENTATIONS AND WARRANTIES.  Lessee and Lessor each represent 
and warrant to the other that it has had no dealings with any person, firm, 
broker or finder in connection with the negotiation of this Lease and/or the 
consummation of the transaction contemplated hereby, and that no broker or 
other person, firm or entity is entitled to any commission or finder's fee in 
connection with said transaction.  Lessee and Lessor do each hereby agree to 
indemnify, protect, defend and hold the other harmless from and against 
liability for compensation or charges which may be claimed by any such 
unnamed broker, finder or other similar party by reason of any dealings or 
actions of the indemnifying Party, including any costs, expenses, and/or 
attorneys' fees reasonably incurred with respect thereto.

16. TENANCY AND FINANCIAL STATEMENTS.

    16.1  TENANCY STATEMENT.  Each Party (as "RESPONDING PARTY") shall within 
ten (10) days after written notice from the other Party (the "Requesting 
Party") execute, acknowledge and deliver to the Requesting Party a statement 
in writing in a form similar to the then most current "Tenancy Statement" 
form published by the American Industrial Real Estate Association, plus such 
additional information, confirmation and/or statements as may be reasonably 
requested by the Requesting Party.

    16.2  FINANCIAL STATEMENT.  If Lessor desires to finance, refinance, or 
sell the Premises or the Building, or any part thereof, Lessee and all 
Guarantors shall deliver to any potential lender or purchaser designated by 
Lessor such financial statements of Lessee and such Guarantors as may be 
reasonably required by such lender or purchaser, including but not limited to 
Lessee's financial statements for the past three (3) years.  All such 
financial statements shall be received by Lessor and such lender or purchaser 
in confidence and shall be used only for the purposes herein set forth.

17. LESSOR'S LIABILITY.  The term "LESSOR" as used herein shall mean the 
owner or owners at the time in question of the fee title to the Premises. In 
the event of a transfer of Lessor's title or interest in the Premises or in 
this Lease, Lessor shall deliver lo the transferee or assignee (in cash or by 
credit) any unused Security Deposit held by Lessor at the time of such 
transfer or assignment.  Except as provided in Paragraph 15.3, upon such 
transfer or assignment and delivery of the Security Deposit, as aforesaid, 
the prior Lessor shall be relieved of all liability with respect to the 
obligations and/or covenants under this Lease thereafter to be performed by 
the Lessor. Subject to the foregoing, the obligations and/or covenants in 
this Lease to be performed by the Lessor shall be binding only upon the 
Lessor as hereinabove defined.

18. SEVERABILITY.  The invalidity of any provision of this Lease, as 
determined by a court of competent jurisdiction, shall in no way affect the 
validity of any other provision hereof.

19. INTEREST ON POST-DUE OBLIGATIONS.  Any monetary payment due Lessor 
hereunder, other than late charges, not received by Lessor within ten (10) 
days following the date on which it was due, shall bear interest from the 
date due at the prime rate charged by the largest state chartered bank in the 
state in which the Premises are located plus two percent (2%) per annum, but 
not exceeding the maximum rate allowed by law, in addition to the potential 
late charge provided for in Paragraph 13.4.

20. TIME OF ESSENCE. Time is of the essence with respect to the performance 
of all obligations to be performed or observed by the Parties under this 
Lease.

21. RENT DEFINED.  All monetary obligations of Lessee to Lessor under the 
terms of this Lease are deemed to be rent.

22. NO PRIOR OR OTHER AGREEMENTS; BROKER DISCLAIMER.  This Lease contains all 
agreements between the Parties with respect to any matter mentioned herein, 
and no other prior or contemporaneous agreement or understanding shall be 
effective.  Lessor and Lessee each represents and warrants to the Brokers 
that it has made, and is relying solely upon, its own investigation as to the 
nature, quality, character and financial responsibility of the other Party to 
this Lease and as to the nature, quality and character of the Premises.  
Brokers have no responsibility with respect thereto or with respect to any 
default or breach hereof by either Party.  Each Broker shall be an intended 
third party beneficiary of the provisions of this Paragraph 22.

23. NOTICES.

    23.1  NOTICE REQUIREMENTS.  All notices required or permitted by this 
Lease shall be in writing and may be delivered in person (by hand or by 
messenger or courier service) or may be sent by regular, certified or 
registered mail or U.S. Postal Service Express Mail, with postage prepaid, or 
by facsimile transmission during normal business hours, and shall be deemed 
sufficiently given if served in a manner specified in this Paragraph 23.  The 
addresses noted adjacent to a Party's signature on this Lease shall be that 
Party's address for delivery or mailing of notice purposes.  Either Party may 
by written notice to the other specify a different address for notice 
purposes, except that upon Lessee's taking possession of the Premises, the 
Premises shall constitute Lessee's address for the purpose of mailing or 
delivering notices to Lessee.  A copy of all notices required or permitted to 
be given to Lessor hereunder shall be concurrently transmitted to such party 
or parties at such addresses as Lessor may from time to time hereafter 
designate by written notice to Lessee.

    23.2  DATE OF NOTICE.  Any notice sent by registered or certified mail, 
return receipt requested, shall be deemed given on the date of delivery shown 
on the receipt card, or if no delivery date is shown, the postmark thereon.  
If sent by regular mail, the notice shall be deemed given three business days 
after the same is addressed as required herein and mailed with postage 
prepaid.  Notices delivered by United States Express Mail or overnight 
courier that guarantees next day delivery shall be deemed given twenty-four 
(24) hours after delivery of the same to the United States Postal Service or 
courier.  If any notice is transmitted by facsimile transmission or similar 
means, the same shall be deemed served or delivered upon telephone or 
facsimile confirmation of receipt of the transmission thereof, provided a 
copy is also delivered via delivery or mail.  If notice is received on a 
Saturday or a Sunday or a legal holiday, it shall be deemed received on the 
next business day.

24. WAIVERS.  No waiver by Lessor of the Default or Breach of any term, 
covenant or condition hereof by Lessee, shall be deemed a waiver of any other 
term, covenant or condition hereof, or of any subsequent Default or Breach by 
Lessee of the same or any other term, covenant or condition hereof.  Lessor's 
consent to, or approval of, any such act shall not be deemed to render 
unnecessary the obtaining of Lessor's consent to, or approval of, any 
subsequent or similar act by Lessee, or be construed as the basis of an 
estoppel to enforce the provision or provisions of this Lease requiring such 
consent.  Regardless of Lessor's knowledge of a Default or Breach at the time 
of accepting rent, the acceptance of rent by Lessor shall not be a waiver of 
any Default or Breach by Lessee of any provision hereof.  Any payment given 
Lessor by Lessee may be accepted by Lessor on account of moneys or damages 
due Lessor, notwithstanding any qualifying statements or conditions made by 
Lessee in connection 

                                   -10-

<PAGE>

therewith, which such statements and/or conditions shall be of no force or 
effect whatsoever unless specifically agreed to in writing by Lessor at or 
before the time of deposit of such payment.

25. RECORDING.  Either Lessor or Lessee shall, upon request of the other, 
execute, acknowledge and deliver to the other a short form memorandum of this 
Lease for recording purposes.  The Party requesting recordation shall be 
responsible for payment of any fees or taxes applicable thereto.

26. NO RIGHT TO HOLDOVER.  Lessee has no right to retain possession of the 
Premises or any part thereof beyond the expiration or earlier termination of 
this Lease.  In the event that Lessee holds over in violation of this 
Paragraph 26 then the Base Rent payable from and after the time of the 
expiration or earlier termination of this Lease shall be increased to one 
hundred fifty percent (150%) of the Base Rent applicable during the month 
immediately preceding such expiration or earlier termination.  Nothing 
contained herein shall be construed as a consent by Lessor to any holding 
over by Lessee.

27. CUMULATIVE REMEDIES.  No remedy or election hereunder shall be deemed 
exclusive but shall, wherever possible, be cumulative with all other remedies 
at law or in equity.

28. BINDING EFFECT; CHOICE OF LAW.  This Lease shall be binding upon the 
Parties, their personal representatives, successors and assigns and be 
governed by the laws of the State in which the Premises are located.  Any 
litigation between the Parties hereto concerning this Lease shall be 
initiated in the county in which the Premises are located.

29. SUBORDINATION; ATTORNMENT; NON-DISTURBANCE.

    29.1  SUBORDINATION.  This Lease and any Option granted hereby shall be 
subject and subordinate to any ground lease, mortgage, deed of trust, or 
other hypothecation or security device (collectively, "SECURITY DEVICE"), now 
or hereafter placed by Lessor upon the real property of which the Premises 
are a part, to any and all advances made on the security thereof, and to all 
renewals, modifications, consolidations, replacements and extensions thereof. 
 Lessee agrees that the Lenders holding any such Security Device shall have 
no duty, liability or obligation to perform any of the obligations of Lessor 
under this Lease, but that in the event of Lessor's default with respect to 
any such obligation, Lessee will give any Lender whose name and address have 
been furnished Lessee in writing for such purpose notice of Lessor's default 
pursuant to Paragraph 13.5.  If any Lender shall elect to have this Lease 
and/or any Option granted hereby superior to the lien of its Security Device 
and shall give written notice thereof to Lessee, this Lease and such Options 
shall be deemed prior to such Security Device, notwithstanding the relative 
dates of the documentation or recordation thereof.

    29.2  ATTORNMENT.  Subject to the non-disturbance provisions of Paragraph 
30.3, Lessee agrees to attorn to a Lender or any other party who acquires 
ownership of the Premises by reason of a foreclosure of a Security Device, 
and that in the event of such foreclosure, such new owner shall not:  (i) be 
liable for any act or omission of any prior lessor or with respect to events 
occurring prior to acquisition of ownership, (ii) be subject to any offsets 
or defenses which Lessee might have against any prior lessor, or (iii) be 
bound by prepayment of more than one month's rent.

    29.3  NON-DISTURBANCE.  With respect to Security Devices entered into by 
Lessor after the execution of this lease, Lessee's subordination of this 
Lease shall be subject to receiving assurance (a "non-disturbance agreement") 
from the Lender that Lessee's possession and this Lease, including any 
options to extend the term hereof, will not be disturbed so long as Lessee is 
not in Breach hereof and attorns to the record owner of the Premises.

    29.4  SELF-EXECUTING.  The agreements contained in this Paragraph 30 
shall be effective without the execution of any further documents; provided, 
however, that upon written request from Lessor or a Lender in connection with 
a sale, financing or refinancing of Premises, Lessee and Lessor shall execute 
such further writings as may be reasonably required to separately document 
any such subordination or non-subordination, attornment and/or 
non-disturbance agreement as is provided for herein.

30. ATTORNEYS' FEES.  If any Party or Broker brings an action or proceeding 
to enforce the terms hereof or declare rights hereunder, the Prevailing Party 
(as hereafter defined) in any such proceeding, action, or appeal thereon, 
shall be entitled to reasonable attorneys' fees.  Such fees may be awarded in 
the same suit or recovered in a separate suit, whether or not such action or 
proceeding is pursued to decision or judgment.  The term "PREVAILING PARTY" 
shall include, without limitation, a Party or Broker who substantially 
obtains or defeats the relief sought, as the case may be, whether by 
compromise, settlement, judgment, or the abandonment by the other Party or 
Broker of its claim or defense.  The attorneys' fee award shall not be 
computed in accordance with any court fee schedule, but shall be such as to 
fully reimburse all attorneys' fees reasonably incurred.  Lessor shall be 
entitled to attorneys' fees, costs and expenses incurred in preparation and 
service of notices of Default and consultations in connection therewith, 
whether or not a legal action is subsequently commenced in connection with 
such Default or resulting Breach.  Broker(s) shall be intended third party 
beneficiaries of this Paragraph 31.

31. LESSOR'S ACCESS; SHOWING PREMISES; REPAIRS.  Lessor and Lessor's agents 
shall have the right to enter the Premises at any time, in the case of an 
emergency, and otherwise at reasonable times for the purpose of showing the 
same to prospective purchasers, lenders, or lessees, and making such 
alterations, repairs, improvements or additions to the Premises or to the 
Building, as Lessor may reasonably deem necessary.  Lessor may at any time 
place on or about the Premises or Building any ordinary "For Sale" signs and 
Lessor may at any time during the last one hundred eighty (180) days of the 
term hereof place on or about the Premises any ordinary "For Lease" signs.  
All such activities of Lessor shall be without abatement of rent or liability 
to Lessee.

32. AUCTIONS.  Lessee shall not conduct, nor permit to be conducted, either 
voluntarily or involuntarily, any auction upon the Premises without first 
having obtained Lessor's prior written consent.  Notwithstanding anything to 
the contrary in this Lease, Lessor shall not be obligated to exercise any 
standard of reasonableness in determining whether to grant such consent.

33. SIGNS.  Lessee shall not place any sign upon the exterior of the Premises 
or the Building, except that Lessee may, with Lessor's prior written consent, 
install (but not on the roof) such signs as are reasonably required to 
advertise Lessee's own business so long as such signs are in a location 
designated by Lessor and comply with Applicable Requirements and the signage 
criteria established for the Industrial Center by Lessor.  The installation 
of any sign on the Premises by or for Lessee shall be subject to the 
provisions of Paragraph 7 (Maintenance, Repairs, Utility Installations, Trade 
Fixtures and Alterations).  Unless otherwise expressly agreed herein, Lessor 
reserves all rights to the use of the roof of the Building, and the right to 
install advertising signs on the Building, including the roof, which do not 
unreasonably interfere with the conduct of Lessee's business; Lessor shall be 
entitled to all revenues from such advertising signs.

34. TERMINATION; MERGER.  Unless specifically stated otherwise in writing by 
Lessor, the voluntary or other surrender of this Lease by Lessee, the mutual 
termination or cancellation hereof, or a termination hereof by Lessor for 
Breach by Lessee, shall automatically terminate any sublease or lesser estate 
in the Premises; provided, however, Lessor shall, in the event of any such 
surrender, termination or cancellation, have the option to continue any one 
or all of any existing subtenancies.  Lessor's failure within ten (10) days 
following any such event to make a written election to the contrary by 
written notice to the holder of any such lesser interest, shall constitute 
Lessor's election to have such event constitute the termination of such 
interest.

35. CONSENTS.

         (a)  Except for Paragraph 33 hereof (Auctions) or as otherwise 
provided herein, wherever in this Lease the consent of a Party is required to 
an act by or for the other Party, such consent shall not be unreasonably 
withheld or delayed.  Lessor's actual reasonable costs and expenses 
(including but not limited to architects', attorneys', engineers' and other 
consultants' fees) incurred in the consideration of, or response to, a 
request by Lessee for any Lessor consent pertaining to this Lease or the 
Premises, including but not limited to consents to an assignment, a 
subletting or the presence or use of a Hazardous Substance, shall be paid by 
Lessee to Lessor upon receipt of an invoice and supporting documentation 
therefor.  In addition to the deposit described in Paragraph 12.2(e), Lessor 
may, as a condition to considering any such request by Lessee, require that 
Lessee deposit with Lessor an amount of money (in addition to the Security 
Deposit held under Paragraph 5) reasonably calculated by Lessor to represent 
the cost Lessor will incur in considering and responding to Lessee's request. 
 Any unused portion of said deposit shall be refunded to Lessee without 
interest.  Lessor's consent to any act, assignment of this Lease or 
subletting of the Premises by Lessee shall not constitute an acknowledgment 
that no Default or Breach by Lessee of this Lease exists, nor shall such 
consent be deemed a waiver of any then existing Default or Breach, except as 
may be otherwise specifically stated in writing by Lessor at the time of such 
consent.

         (b)  All conditions to Lessor's consent authorized by this Lease are 
acknowledged by Lessee as being reasonable.  The failure to specify herein 
any particular condition to Lessor's consent shall not preclude the 
impositions by Lessor at the time of consent of such further or other 
conditions as are then reasonable with reference to the particular matter for 
which consent is being given.

                                       -11-

<PAGE>


36. GUARANTOR.

    36.1  FORM OF GUARANTY.  If there are to be any Guarantors of this Lease 
per Paragraph 1.11, the form of the guaranty to be executed by each such 
Guarantor shall be in the form most recently published by the American 
Industrial Real Estate Association, and each such Guarantor shall have the 
same obligations as Lessee under this lease, including but not limited to the 
obligation to provide the Tenancy Statement and information required in 
Paragraph 16.

    36.2  ADDITIONAL OBLIGATIONS OF GUARANTOR.  It shall constitute a Default 
of the Lessee under this Lease if any such Guarantor fails or refuses, upon 
reasonable request by Lessor to give:  (a) evidence of the due execution of 
the guaranty called for by this Lease, including the authority of the 
Guarantor (and of the party signing on Guarantor's behalf) to obligate such 
Guarantor on said guaranty, and resolution of its board of directors 
authorizing the making of such guaranty, together with a certificate of 
incumbency showing the signatures of the persons authorized to sign on its 
behalf, (b) current financial statements of Guarantor as may from time to 
time be requested by Lessor, (c) a Tenancy Statement, or (d) written 
confirmation that the guaranty is still in effect.

37. QUIET POSSESSION.  Upon payment by Lessee of the rent for the Premises 
and the performance of all of the covenants, conditions and provisions on 
Lessee's part to be observed and performed under this Lease, Lessee shall 
have quiet possession of the Premises for the entire term hereof subject to 
all of the provisions of this Lease.

38. OPTIONS.

    38.1  DEFINITION.  As used in this Lease, the word "OPTION" has the 
following meaning:  (a) the right to extend the term of this Lease or to 
renew this Lease or to extend or renew any lease that Lessee has on other 
property of Lessor; (b) the right of first refusal to lease the Premises or 
the right of first offer to lease the Premises or the right of first refusal 
to lease other property of Lessor or the right of first offer to lease other 
property of Lessor; (c) the right to purchase the Premises, or the right of 
first refusal to purchase the Premises, or the right of first offer to 
purchase the Premises, or the right to purchase other property of Lessor, or 
the right of first refusal to purchase other property of Lessor, or the right 
of first offer to purchase other property of Lessor.

    38.2  OPTIONS PERSONAL TO ORIGINAL LESSEE.  Each Option granted to Lessee 
in this Lease is personal to the original Lessee named in Paragraph 1.1 
hereof, and cannot be voluntarily or involuntarily assigned or exercised by 
any person or entity other than said original Lessee while the original 
Lessee is in full and actual possession of the Premises and without the 
intention of thereafter assigning or subletting.  The Options, if any, herein 
granted to Lessee are not assignable, either as a part of an assignment of 
this Lease or separately or apart therefrom, and no Option may be separated 
from this Lease in any manner, by reservation or otherwise.

    38.3  MULTIPLE OPTIONS.  In the event that Lessee has any multiple 
Options to extend or renew this Lease, a later option cannot be exercised 
unless the prior Options to extend or renew this Lease have been validly 
exercised.

    38.4  EFFECT OF DEFAULT ON OPTIONS.

          (a)  Lessee shall have no right to exercise an Option, 
notwithstanding any provision in the grant of Option to the contrary: (i) 
during the period commencing with the giving of any notice of Default under 
Paragraph 13.1 and continuing until the noticed Default is cured, or (ii) 
during the period of time any monetary obligation due Lessor from Lessee is 
unpaid (without regard to whether notice thereof is given Lessee), or (iii) 
during the time Lessee is in Breach of this Lease, or (iv) in the event that 
Lessor has given to Lessee three (3) or more notices of separate Defaults 
under Paragraph 13.1 during the twelve (12) month period immediately 
preceding the exercise of the Option, whether or not the Defaults are cured.

          (b)  The period of time within which an Option may be exercised 
shall not be extended or enlarged by reason of Lessee's inability to exercise 
an Option because of the provisions of Paragraph 39.4(a).

          (c)  All rights of Lessee under the provisions of an Option shall 
terminate and be of no further force or effect, notwithstanding Lessee's due 
and timely exercise of the Option, if, after such exercise and during the 
term of this Lease, (i) Lessee fails to pay to Lessor a monetary obligation 
of Lessee for a period of thirty (30) days after such obligation becomes due 
(without any necessity of Lessor to give notice thereof to Lessee), or (ii) 
Lessor gives to Lessee three (3) or more notices of separate Defaults under 
Paragraph 13.1 during any twelve (12) month period, whether or not the 
Defaults are cured, or (iii) if Lessee commits a Breach of this Lease.

39. RULES AND REGULATIONS.  Lessee agrees that it will abide by, and keep 
and observe all reasonable rules and regulations ("Rules and Regulations") 
which Lessor may make from time to time for the management, safety, care, and 
cleanliness of the grounds, the parking and unloading of vehicles and the 
preservation of good order, as well as for the convenience of other occupants 
or tenants of the Building and the Industrial Center and their invites.

40. SECURITY MEASURES.  Lessee hereby acknowledges that the rental payable 
to Lessor hereunder does not include the cost of guard service or other 
security measures, and that Lessor shall have no obligation whatsoever to 
provide same.  Lessee assumes all responsibility for the protection of the 
Premises, Lessee, its agents and invites and their property from the acts of 
third parties.

41. RESERVATIONS.  Lessor reserves the right, from time to time, to grant, 
without the consent or joinder of Lessee, such easements, rights of way, 
utility raceways, and dedications that Lessor deems necessary, and to cause 
the recordation of parcel maps and restrictions, so long as such easements, 
rights of way, utility raceways, dedications, maps and restrictions do not 
reasonably interfere with the use of the Premises by Lessee.  Lessee agrees 
to sign any documents reasonably requested by Lessor to effectuate any such 
easement rights, dedication, map or restrictions.

42. PERFORMANCE UNDER PROTEST.  If at any time a dispute shall arise as to 
any amount or sum of money to be paid by one Party to the other under the 
provisions hereof, the Party against whom the obligation to pay the money is 
asserted shall have the right to make payment "under protest" and such 
payment shall not be regarded as a voluntary payment and there shall survive 
the right on the part of said Party to institute suit for recovery of such 
sum.  If it shall be adjudged that there was no legal obligation on the part 
of said Party to pay such sum or any part thereof, said Party shall be 
entitled to recover such sum or so much thereof as it was not legally 
required to pay under the provisions of this Lease.

43. AUTHORITY.  If either Party hereto is a corporation, trust, or general or 
limited partnership, each individual executing this Lease on behalf of such 
entity represents and warrants that he or she is duly authorized to execute 
and deliver this Lease on its behalf.  If Lessee is a corporation, trust or 
partnership, Lessee shall, within thirty (30) days after request by Lessor, 
deliver to Lessor evidence satisfactory to Lessor of such authority.

44. CONFLICT.  Any conflict between the printed provisions of this Lease and 
the typewritten or handwritten provisions shall be controlled by the 
typewritten or handwritten provisions.

45. OFFER.  Preparation of this Lease by either Lessor or Lessee or Lessor's 
agent or Lessee's agent and submission of same to Lessee or Lessor shall not 
be deemed an offer to lease.  This Lease is not intended to be binding until 
executed and delivered by all Parties hereto.

46. AMENDMENTS.  This Lease may be modified only in writing, signed by the 
parties in interest at the time of the modification.  The Parties shall amend 
this Lease from time to time to reflect any adjustments that are made to the 
Base Rent or other rent payable under this Lease.  As long as they do not 
materially change Lessee's obligations hereunder, Lessee agrees to make such 
reasonable non-monetary modifications to this Lease as may be reasonably 
required by an institutional insurance company or pension plan Lender in 
connection with the obtaining of normal financing or refinancing of the 
property of which the Premises are a part.

47. MULTIPLE PARTIES.  Except as otherwise expressly provided herein, if more 
than one person or entity is named herein as either Lessor or Lessee, the 
obligations of such multiple parties shall be the joint and several 
responsibility of all persons or entities named herein as such Lessor or 
Lessee.

                                  -12-

<PAGE>


LESSOR AND LESSEE HAVE CAREFULLY READ AND REVIEWED THIS LEASE AND EACH TERM
AND PROVISION CONTAINED HEREIN, AND BY THE EXECUTION OF THIS LEASE SHOW
THEIR INFORMED AND VOLUNTARY CONSENT THERETO.  THE PARTIES HEREBY AGREE
THAT, AT THE TIME THIS LEASE IS EXECUTED, THE TERMS OF THIS LEASE ARE
COMMERCIALLY REASONABLE AND EFFECTUATE THE INTENT AND PURPOSE OF LESSOR AND
LESSEE WITH RESPECT TO THE PREMISES.

        IF THIS LEASE HAS BEEN FILLED IN, IT HAS BEEN PREPARED FOR YOUR
        ATTORNEY'S REVIEW AND APPROVAL.  FURTHER, EXPERTS SHOULD BE
        CONSULTED TO EVALUATE THE CONDITION OF THE PROPERTY FOR THE
        POSSIBLE PRESENCE OF ASBESTOS, UNDERGROUND STORAGE TANKS OR
        HAZARDOUS SUBSTANCES.  NO REPRESENTATION OR RECOMMENDATION IS
        MADE BY THE AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION OR BY
        THE REAL ESTATE BROKERS OR THEIR CONTRACTORS, AGENTS OR
        EMPLOYEES AS TO THE LEGAL SUFFICIENCY, LEGAL EFFECT, OR TAX
        CONSEQUENCES OF THIS LEASE OR THE TRANSACTION TO WHICH IT
        RELATES; THE PARTIES SHALL RELY SOLELY UPON THE ADVICE OF THEIR
        OWN COUNSEL AS TO THE LEGAL AND TAX CONSEQUENCES OF THIS LEASE. 
        IF THE SUBJECT PROPERTY IS IN A STATE OTHER THAN CALIFORNIA, AN
        ATTORNEY FROM THE STATE WHERE THE PROPERTY IS LOCATED SHOULD BE
        CONSULTED.


The parties hereto have executed this Lease at the place and on the dates
specified above their respective signatures.


Executed at:                          Executed at:                       
            ----------------------                --------------------------
on:                                   on:                           
   -------------------------------       -----------------------------------

By LESSOR:                            By LESSEE:

- ----------------------------------    --------------------------------------

- ----------------------------------    --------------------------------------

By:                                   By:                           
   -------------------------------       -----------------------------------
Name Printed:                         Name Printed:                    
             ---------------------                 -------------------------
Title:                                Title:                             
      ----------------------------          --------------------------------
By:                                   By:                           

Name Printed:                         Name Printed:                    
             ---------------------                 -------------------------
Title:                                Title:                             
      ----------------------------          --------------------------------
Address:                              Address:                           
        --------------------------            ------------------------------
                                                               
- ----------------------------------    --------------------------------------
Telephone: (   )                      Telephone: (   )
                ------------------                    ----------------------
Facsimile:  (   )                     Facsimile:  (   )
                 -----------------                     ---------------------

BROKER:                               BROKER:

Executed at:                          Executed at:                       
            ----------------------                --------------------------
on:                                   on:                           
   -------------------------------       -----------------------------------
By:                                   By:                           
   -------------------------------       -----------------------------------
Name Printed:                         Name Printed:                      
             ---------------------                 -------------------------
Title:                                Title:                             
      ----------------------------          --------------------------------
Address:                              Address:                           
        --------------------------            ------------------------------
                                                               
- ----------------------------------    --------------------------------------
Telephone: (   )                      Telephone: (   )                      
                ------------------                    ----------------------
Facsimile:  (   )                     Facsimile:  (   )
                 -----------------                     ---------------------

NOTE:   These forms are often modified to meet changing requirements of
        law and needs of the industry.  Always write or call to make
        sure you are utilizing the most current form:  AMERICAN
        INDUSTRIAL REAL ESTATE ASSOCIATION, 345 So. Figueroa St., M-1,
        Los Angeles, CA 90071.  (213) 687-8777.

<PAGE>



                               EXHIBIT A

                         Depiction of Premises
                                   
                            (To be inserted)

<PAGE>



                               EXHIBIT B
                                   
                    Interior Improvement Agreement
                                   
   This Interior Improvement Agreement (this "Agreement") is made part
of that certain Standard Industrial/Commercial Multi-Lessee Lease of
even date herewith (the "Lease") by and between R&S, LLC, a California
limited liability company ("Lessor"), and QUARK BIOTECH, INC., a
California corporation ("Lessee").  Lessor and Lessee agree that the
following terms are part of the Lease:

   1.   DEFINITIONS:  As used in this Agreement, the following terms
shall have the following meanings, and terms which are not defined
below, but which are defined in the Lease and which are used in this
Agreement, shall have the meanings ascribed to them by the Lease:

        A.   COMMON AREA IMPROVEMENT COSTS.  The term "Common Area
Improvement Costs" shall mean the following:  (i) the total amount due
pursuant to the general construction contract entered into by Lessor to
construct the Common Area Improvements; (ii) the cost of all
governmental approvals required as a condition to the construction of
the Common Area Improvements or in connection with the issuance of a
building permit for the Common Area Improvements; (iii) all utility
connection or use fees; and (iv) the cost of payment and performance
bonds obtained by Lessor or general contractor to assure completion of
the Common Area Improvements.

        B.   COMMON AREA IMPROVEMENTS.  The term "Common Area
Improvements" shall mean all interior improvements to be constructed by
Lessor in the Common Areas in accordance with the terms of this
Agreement. 

        C.   ENGINEERING AND DESIGN COSTS: The term "Engineering and
Design Costs" shall mean all architecture, design and engineering costs
in connection with the construction by Lessor of the Lessee
Improvements, the Common Area Improvements and the Lessor Improvements.  


        D.   GENERAL CONTRACTOR:  The term "General Contractor" shall
mean the general contractor selected by Lessor to construct the Interior
Improvements and Lessor Improvements.

        E.   INTERIOR IMPROVEMENTS.  The term "Interior Improvements"
shall mean collectively the Lessee Improvements and the Common Area
Improvements.

        F.   LESSEE IMPROVEMENT COSTS.  The term "Lessee Improvement
Costs" shall mean the following:  (i) the total amount due pursuant to
any construction contract(s) entered into by Lessor to construct the
Lessee Improvements; (ii) the cost of all governmental approvals
required as a condition to the construction of the Lessee Improvements
or in connection with the issuance of a building permit for the Lessee
Improvements; (iii) all utility connection or use fees; and (iv) the
cost of payment and performance bonds obtained by Lessor or general
contractor to assure completion of the Lessee Improvements. 

        G.   LESSEE IMPROVEMENTS:  The term "Lessee Improvements"
shall mean all interior improvements to be constructed by Lessor in the
Premises in accordance with the terms of this Agreement. 

        H.   LESSOR IMPROVEMENTS:  The term "Lessor Improvements"
shall mean all interior improvements to be constructed by Lessor in the
portion of the Building dedicated exclusively to Lessor.       

        I.   SUBSTANTIAL COMPLETION AND SUBSTANTIALLY COMPLETE:  The
terms "Substantial Completion" and "Substantially Complete" shall each
mean the date when all of the following have occurred with respect to
the Interior Improvements:  (i) the construction of the Interior
Improvements has been substantially completed in accordance with the
requirement of the Lease; (ii) the architect responsible for preparing
the plans shall have executed a certificate or statement representing
that the Interior Improvements in question have been substantially
completed in accordance with the plans and specifications therefor; and
(iii) the building department of the City of Pleasanton has completed
its final inspection of such improvements and has "signed off" the
building inspection card approving such work as complete.

   2.   CONSTRUCTION OF INTERIOR IMPROVEMENTS:  Lessor shall construct
the Interior Improvements in accordance with the following:

        [A.  DEVELOPMENT AND APPROVAL OF PLANS:  

             (1)  PRELIMINARY PLANS:  A floor plan for the Interior
Improvements approved by both Lessor and Lessee is attached to this
Agreement as SCHEDULE 1 ("Approved Floor Plan").  On or before that date
that is five (5) business days after both parties have executed the
Lease, Lessee shall furnish to Lessor all other information reasonably
required by Lessor to complete preliminary plans for the Interior
Improvements shown on the Approved Floor Plan.  Within ten (10) days
after Lessee has delivered all of the required information to Lessor,
Lessor shall prepare and deliver to Lessee for its review and approval
preliminary plans for the Interior Improvements with conform to the
Approved Floor Plan (the "Preliminary Plans").  Within five (5) business
days after Lessor's delivery of the


                                 -1-

<PAGE>


Preliminary Plans, Lessee shall either approve such plans or notify Lessor in 
writing of its specific objections to the Preliminary Plans.  If Lessee so 
objects, Lessor shall revise the Preliminary Plans to address such objections 
in a manner consistent with the parameters for the Interior Improvements set 
forth in this Agreement and the Approved Floor Plan and shall resubmit such 
revised Preliminary Plans as soon as reasonably practicable to Lessee for its 
approval.  When such revised Preliminary Plans are resubmitted to Lessee, it 
shall either approve such plans or notify Lessor of any further objections in 
writing within five (5) business days after receipt thereof.  If Lessee has 
further objections to the revised Preliminary Plans, the parties shall meet 
and confer to develop Preliminary Plans that are acceptable to both Lessor 
and Lessee within five (5) business days after Lessee has notified Lessor of 
its second set of objections.  In the event Lessee and Lessor do not resolve 
all of Lessee's objections within such five (5) business day period, Lessor 
and Lessee shall immediately cause Lessor's architect to meet and confer with 
Lessee's architect or construction consultant, who shall apply the standards 
set forth in this Agreement to resolve Lessee's objections and incorporate 
such resolution into the Preliminary Plans, which process Lessor and Lessee 
shall cause to be completed within five (5) business days after the 
conclusion of the five (5) business day period referred to in the immediately 
preceding sentence. 

             (2)  FINAL PLANS:  Once the Preliminary Plans have been
approved by Lessor and Lessee (including changes made to resolve
Lessee's objections approved by Lessor's architect and Lessee's
architect or construction consultant, if any), Lessor shall complete and
submit to Lessee for its approval final working drawings for the
Interior Improvements.  Lessee shall approve the final plans for the
Interior Improvements or notify Lessor in writing of its specific
objections within five (5) business days after their submission by
Lessor.  If Lessee so objects, the parties shall confer and reach
agreement upon final working drawings for the Interior Improvements
within five (5) business days after Lessee has notified Lessor of its
objections.  If Lessee and Lessor do not resolve all of Lessee's
objections within such five (5) business day period, Lessor and Lessee
shall immediately cause Lessor's architect to meet and confer with
Lessee's architect or construction consultant, who shall apply the
standards set forth in this Agreement to resolve Lessee's objections and
incorporate such resolution into the Final Plans, which process Lessor
and Lessee shall cause to be completed within five (5) business days
after the conclusion of the five (5) business day period referred to in
the immediately preceding sentence.  The final working drawings so
approved by Lessor and Lessee (including all changes made to resolve
Lessee's objections approved by Lessor's architect, Lessee's architect
or construction consultant) are referred to herein as the "Final
Plans."]

        B.   CONSTRUCTION CONTRACT:  Lessor and Lessee shall cooperate
to cause the Interior Improvements to be constructed by General
Contractor pursuant to a construction contract entered into by Lessor
and General Contractor.

        C.   COMMENCEMENT OF INTERIOR IMPROVEMENTS:  Promptly
following approval of the Final Plans and Lessor obtaining all required
governmental approvals and permits, Lessor shall commence construction
of the Interior Improvements and shall diligently prosecute such
construction to completion.  Lessor shall use reasonable efforts to
achieve Substantial Completion of the Interior Improvements as soon as
reasonably practicable. 

   3.   PAYMENT OF INTERIOR IMPROVEMENT COSTS: Lessee shall have the
following obligations with respect to the payment of costs for the
Interior Improvements:

        A.   Lessee shall be responsible for and shall pay to Lessor
the following: (i) the entire amount of Lessee Improvement Costs; (ii)
Lessee's Share of Common Area Improvement Costs, provided, however, that
Lessee shall pay fifty percent (50%) of all costs arising in connection
with the purchase and installation of backup power generators ; (iii)
Lessee's Share of Engineering and Design Costs incurred by Lessor; (iv)
the entire amount of costs incurred by Lessor due to Lessee Delays (as
defined hereinafter); and (v) a management fee in the amount of five
percent (5%) of all of the costs set forth in the preceding clauses (i)
through (iv).  Upon execution of this Lease, Lessee shall pay to Lessor
One Hundred Thousand Dollars ($100,000) ("Lessee's Prepayment"), which
amount shall be applied by Lessor towards Lessee's payment obligations
under this Agreement.  If any of the foregoing costs exceed the amount
of Lessee's Prepayment, then Lessee shall reimburse any such excess
costs to Lessor within five (5) days after Lessee's receipt of a written
request by Lessor; each such request shall include reasonable supporting
backup documentation.  If upon the completion of and final payment by
Lessor with respect to the Interior Improvements there remains any
unused portion of Lessee's Prepayment, then such unused portion shall
thereafter promptly be refunded by Lessor to Lessee.

   4.   CHANGES TO APPROVED PLANS:  Once the Final Plans have been
approved by Lessor and Lessee, neither shall have the right to order
extra work or change orders with respect to the construction of the
Interior Improvements without the prior written consent of the other,
which consent shall not be unreasonably withheld provided that there is
a reasonable basis for such change.  All extra work or change orders
requested by either Lessor or Lessee shall be made in writing, shall
specify any added or reduced cost and/or construction time resulting
therefrom, and shall become effective and a part of the Final Plans once
approved in writing by both parties.  If a change order requested by
Lessee results in an increase in the cost of constructing the Interior
Improvements, Lessee shall pay the amount of such increase caused by the
change order requested by Lessee at the time the change order is
approved by both Lessor and Lessee.  


                                  -2-
<PAGE>


   5.   DELAY IN COMPLETION CAUSED BY LESSEE:  The parties hereto
acknowledge that the date on which Lessee's obligation to pay rent would
otherwise commence may be delayed because of (i) Lessee's failure to
submit necessary information to Lessor when required or to promptly
review and approve the plans for the Interior Improvements in accordance
with the Schedule for Performance, (ii) any act by Lessee which
interferes with or delays the completion of the plans for the Interior
Improvements or Lessor's construction work, (iii) change orders
requested by Lessee and approved by Lessor, or (iv) special materials or
equipment ordered or specified by Lessee that cannot be obtained by
Lessor at normal cost within a reasonable period of time because of
limited availability (collectively, "Lessee Delays").  It is the intent
of the parties hereto that the commencement of Lessee's obligation to
pay Base Rent and all other charges under the Lease not be delayed by
any of such causes or by any other act of Lessee, and in the event it is
so delayed, Lessee's obligation to pay the Base Rent and all other
charges under the Lease shall commence as of the date it would otherwise
have commenced absent delay caused by Lessee.

   6.   DELIVERY OF POSSESSION, PUNCH LIST, AND ACCEPTANCE AGREEMENT: 
As soon as the Interior Improvements are Substantially Completed, Lessor
and Lessee shall together walk through the Premises and inspect all
Interior Improvements so completed, using reasonable efforts to discover
all uncompleted or defective construction in the Interior Improvements. 
After such inspection has been completed, each party shall sign an
acceptance agreement in the form attached to this Agreement as SCHEDULE
2, which shall (i) include a list of all "punch list" items which the
parties agree are to be corrected by Lessor and (ii) shall state the
Commencement Date and the initial Base Rent.  As soon as such inspection
has been completed and such acceptance agreement executed, Lessor shall
deliver possession of the Premises to Lessee.  Lessor shall use
reasonable efforts to complete and/or repair such "punch list" items
within thirty (30) days after executing the acceptance agreement. 
Lessor shall have no obligation to deliver possession of the Premises to
Lessee until such procedures regarding the preparation of a punch list
and the execution of the acceptance agreement have been completed. 
Lessee's taking possession of any part of the Premises shall be deemed
to be an acceptance by Lessee of Lessor's work of improvement in such
part as complete and in accordance with the terms of the Lease except
for the punch list times noted and latent defects that could not
reasonably have been discovered by Lessee during its inspection of the
Interior Improvements prior to completion of the acceptance agreement. 
Notwithstanding anything contained herein, Lessee's obligation to pay
Base Rent and all other charges under the Lease shall commence as
provided in the Lease, regardless of whether Lessee completes such
inspection or executes such acceptance agreement.

   7.   STANDARD OF CONSTRUCTION AND WARRANTY:  Lessor hereby warrants
that the Interior Improvements shall be constructed substantially in
accordance with the Final Plans (as modified by change orders approved
by Lessor and Lessee), in a good and workmanlike manner, and all
materials and equipment furnished shall conform to such final plans and
shall be new and otherwise of good quality.  The foregoing warranty
shall be subject to, and limited by, the following:  (i) once Lessor is
notified in writing of any breach of the above-described warranty,
Lessor shall as soon as is reasonably practicable commence the cure of
such breach and complete such cure with diligence at Lessor's cost; (ii)
Lessor's liability pursuant to such warranty shall be limited to the
cost of correcting the defect or other matter in question, and in no
event shall Lessor be liable to Lessee for any damages or liability
incurred by Lessee as a result of such defect or other matter, including
without limitation damages resulting from any loss of business by Lessee
or other consequential damages; and (iii) notwithstanding anything
contained herein, Lessor shall not be liable for any defect in design,
construction, or equipment furnished which is discovered and of which
Lessor receives written notice from Lessee after the end of the first
six (6) full calendar months following the Commencement Date.  With
respect to defects for which Lessor is not responsible pursuant to this
paragraph, Lessee shall have the benefit of any construction or
equipment warranties existing in favor of Lessor that would assist
Lessee in correcting such defect and in discharging its obligations
regarding the repair and maintenance of the Premises.  Upon request by
Lessee, Lessor shall inform Lessee of all written construction and
equipment warranties existing in favor of Lessor which affect the
Interior Improvements.  Lessor shall cooperate with Lessee in enforcing
such warranties and in bringing any suit that may be necessary to
enforce liability with regard to any defect for which Lessor is not
responsible pursuant to this paragraph so long as Lessee pays all costs
reasonably incurred by Lessor in so acting.  Lessor makes no other
express or impled warranty with respect to the design, construction or
operation of the Interior Improvements except as set forth in this
paragraph 7.

   8.   CONDITION TO LESSOR'S PERFORMANCE:  Lessor's obligations under
the Lease are subject to the satisfaction or waiver of the condition
that Lessor obtain all building permits and other governmental approvals
required in order to commence construction of the Interior Improvements. 
If Lessor, using its good faith efforts, is unable to obtain such
permits or approvals within sixty (60) days after Lessor and Lessee's
approval of the Final Plans, Lessor shall have the option of terminating
the Lease; provided, however, that Lessor shall have the right to extend
the time period for the satisfaction of such condition for a period of
up to sixty (60) additional days to enable Lessor to continue its
efforts to cause such condition to be satisfied.  If any such option to
extend the time for satisfaction of this condition is exercised, (i)
Lessor shall continue to use reasonable efforts to cause the condition
to be satisfied; and (ii) such extension shall not constitute a delay
caused by Lessee pursuant to paragraph 5 hereof, nor shall Lessor in any
may be penalized for exercising such option to obtain additional time to
cause the condition satisfied.  If Lessor becomes entitled to and elects
to so terminate the Lease, the Lease shall terminate on the date notice
is so given to Lessee.  Lessor shall be under an obligation of good
faith to use its reasonable efforts to cause the condition to be
satisfied.


                                   -3-
<PAGE>


   9.   EFFECT OF AGREEMENT:  Unless otherwise defined herein, all
capitalized terms used herein shall have the meanings ascribed to them
in the Lease.  In the event of any inconsistency between this Agreement
and the Lease, the terms of this Agreement shall prevail.

LESSOR:                                    LESSEE:
- ------                                     ------
R&S, LLC,                                  QUARK BIOTECH, INC.,
a California limited liability company     a California corporation

By                                         By                       
  ------------------------------------       ------------------------------
Name                                       Name                     
    ----------------------------------         ----------------------------
Its                                        Its                      
   -----------------------------------        -----------------------------
Dated                                      Dated                    
     ---------------------------------          ---------------------------





                                       -4-



<PAGE>



                               SCHEDULE 1

                               Final Plans

                            (To be inserted)





                                    -5-

<PAGE>





                               SCHEDULE 2

                          Acceptance Agreement



     THIS ACCEPTANCE AGREEMENT, is made as of _____________, 199_, by
and between the parties hereto with regard to that lease (the "Lease")
dated  __________________, 1997, by and between R & S, LLC, a California
limited liability company, ("Lessor"), and QUARK BIOTECH, INC., a
California corporation ("Lessee"), affecting those premises commonly
known as 1059 Serpentine Lane, Pleasanton, California.  The parties
hereto agree as follows:

     1.   All Lessee Improvements and Common Area Improvements required
to be constructed pursuant to the Interior Improvement Agreement have
been completed in accordance with the terms of the Lease, subject to the
completion of punchlist items identified on ATTACHMENT "A" attached
hereto.

     2.   Possession of the Premises has been delivered to Lessee and
Lessee has accepted and taken possession of the Premises.

     3.   The Commencement Date of the Lease Term is ___________, 199_,
and the Lease Term shall expire on the last day of the thirty-sixth
(36th) full calendar month following the Commencement Date, unless
sooner terminated or extended according to the terms of the Lease.

     4.   The Lease is in full force and effect, neither party is in
default of its obligations under the Lease, and Lessee has no setoffs,
claims, or defenses to the enforcement of the Lease.


LESSOR:                             LESSEE:
- ------                              ------
R & S, LLC, a California            QUARK BIOTECH, INC., a California
limited liability company           corporation

By:                                 By:                           
   ---------------------------         ----------------------------
Printed                             Printed   
Name:                               Name:                          
     -------------------------           --------------------------
Title:                              Title:                        
      ------------------------            -------------------------
Date:                               Date:                         
     -------------------------           --------------------------



                                 -6-

<PAGE>


                  ATTACHMENT "A" TO ACCEPTANCE AGREEMENT
                                   
                               PUNCHLIST
                                   
                            [to be attached]



                                   -7-


<PAGE>

                           FIRST ADDENDUM TO LEASE

    THIS FIRST ADDENDUM TO LEASE (this "Addendum") is made by and between 
R&S, LLC, a California limited liability company ("Lessor"), and QUARK 
BIOTECH, INC., a California corporation ("Lessee"), to be a part of that 
certain Standard Industrial/Commercial Multi-Lessee Lease of even date 
herewith between Lessor and Lessee (the "Lease Form") concerning 
approximately 3,287 square feet of space (the "Premises") located at 1059 
Serpentine Lane, Pleasanton, California (the "Building").  Lessor and Lessee 
agree that, notwithstanding anything to the contrary in the Lease Form, the 
Lease Form is hereby modified and supplemented as set forth below.

    1. DEFINITIONS.  Unless otherwise defined in this Addendum, all the terms 
used in this Addendum shall have the same meaning and definition given them 
in the Lease Form.  As used in this Addendum, the term "Lease Form" shall 
mean the printed lease form, together with all exhibits and attachments 
thereto, to which this Addendum is attached. As used herein, the term "Lease" 
shall mean the Lease Form, this Addendum, and all other addenda, exhibits, 
and attachments to the Lease Form referred to in the Lease Form or in this 
Addendum.

    2. TERM.  The Lease shall commence (the "Commencement Date") on the date 
by which all of the following have occurred:  (i) Lessor has "Substantially 
Completed" the "Lessee Improvements" as defined in EXHIBIT B to the Lease; 
and (ii) Lessee has delivered possession of the Premises to Lessee. 

    3. COMMON AREA OPERATING EXPENSES.  "Common Area Operating Expenses" 
shall not include the following:  (i) costs for which Landlord has a right of 
reimbursement from others, (ii) costs to comply with any Applicable Law on 
the Commencement Date; (iii) costs which would properly be capitalized under 
generally accepted accounting principles ("GAAP") except to the extent that 
Lessee's Share of such cost during any twelve-month period of the Lease is 
amortized (with interest at twelve percent (12%) or the highest amount 
allowed by Applicable Law, whichever is less) over the useful life of the 
capital item in question determined in accordance with GAAP; or (iv) reserves 
set aside for maintenance and repair of Common Areas.

    4. COMPLIANCE WITH LAWS.  Lessee shall not be required to comply with or 
cause the Premises to comply with any Applicable Laws requiring improvements 
or alterations unless such compliance is necessitated by reason of (i) 
Lessee's particular use or occupancy of the Premises, or (ii) alterations 
constructed in the Premises by, or at the request of, Lessee.  
Notwithstanding the foregoing, all expenses incurred by Lessor in regard to 
compliance with Applicable Laws shall be a Common Area Operating Expense of 
which Lessee must pay Lessee's Share as set forth in the Lease.  

    5. HAZARDOUS SUBSTANCES.  Without limiting the generality of Lessee's 
obligations set forth in Section 6 of the Lease Form:

       (a)  Prior to executing the Lease, Lessee has completed, executed and 
delivered to Lessor the Hazardous Substances Questionnaire (the 
"Questionnaire"), a copy of which is attached to this Addendum as SCHEDULE 1. 
Lessee represents and warrants to Lessor that the information contained in 
the Questionnaire is true and correct and accurately describes the use(s) of 
Hazardous Substances which will be made or used on the Premises by Lessee.  
Lessee shall commencing with the date which is one (1) year from the 
Commencement Date and continuing every year thereafter during the Lease Term, 
complete, execute and deliver to Lessor a Questionnaire (in the form set 
forth in SCHEDULE 1), describing Lessee's present use of Hazardous Substances 
on the Premises, and any other reasonably necessary documents as requested by 
Lessor.  Lessee shall not cause or permit any Hazardous Substance to be 
brought upon, kept, stored or used on or about the Industrial Center without 
the prior written consent of Lessor.  Lessor hereby consents to Lessee's use 
of the substances described on SCHEDULE 1.  

       (b)  Any handling, transportation, storage, treatment, disposal or use 
of Hazardous Substances by Lessee or its agents, contractors, licensees or 
invitees in or about the Industrial Center shall strictly comply with all 
Applicable Requirements.  Lessee shall protect, indemnify, defend upon demand 
with counsel reasonably acceptable to Lessor, and hold harmless Lessor from 
and against any liabilities, losses, claims, damages, lost profits, 
consequential damages, interest, penalties, fines, monetary sanctions, 
attorneys' fees, experts' fees, court costs, remediation costs, investigation 
costs, and other expenses which result from or arise in any manner whatsoever 
out of the use, storage, treatment, transportation, release or disposal of 
Hazardous Substances on or about the Premises or the Industrial Center by 
Lessee or its agents, contractors, licensees or invitees.  

       (c)  If the presence of Hazardous Substances on the Industrial Center 
caused by Lessee or its agents, contractors, licensees or invitees results in 
contamination or deterioration of water or soil resulting in a level of 
contamination greater than the levels established as acceptable by any 
governmental agency having jurisdiction over such contamination, then Lessee 
shall promptly take any and all action necessary to investigate and remediate 
such contamination and comply with all Applicable Requirements in connection 
therewith.  Lessee shall further be solely responsible for, and shall 
protect, defend, indemnify and hold Lessor and its agents and employees 
harmless from and against, all claims, costs and liabilities, including 
attorneys' fees and costs, arising out of or in connection 

                                  -1-

<PAGE>

with any investigation or remediation required hereunder to return the 
Industrial Center to its condition existing prior to the appearance of such 
Hazardous Substances.

       (d)  The provisions of this Paragraph 5 shall survive the termination 
of the Lease.

    6. MAINTENANCE, REPAIRS.  Lessor shall perform and construct any 
necessary repairs or maintenance to the heating, ventilating, air 
conditioning, electrical, water, sewer, and plumbing systems serving the 
Premises and the Building, and to any portion of the Building outside of the 
demising walls of the Premises, except for damage occasioned by the acts or 
omissions of Lessee, its employees, agents, contractors or invitees, which 
damage shall promptly be repaired by Lessee at Lessee's expense, subject to 
the waiver of subrogation rights set forth in Section 8.6 of the Lease Form.  
Notwithstanding the foregoing, all expenses incurred by Lessor in regard to 
the foregoing shall be a Common Area Operating Expense of which Lessee must 
pay Lessee's Share as set forth in the Lease Form and this Addendum.  

    7. INDEMNITY.  Lessor shall not be released or indemnified by Lessee from 
any losses, damages, liabilities, judgments, actions, claims, attorneys' 
fees, consultants' fees, payments, costs and expenses arising from the gross 
or active negligence or willful misconduct of Lessor or its employees, 
authorized agents or contractors.

    8. BASE RENT ADJUSTMENT.  Commencing as of the first day of the 
thirteenth (13th) full calendar month following the Commencement Date, and 
continuing on each annual anniversary of such day throughout the remainder of 
the Lease Term (each such day being referred to as a "Rent Adjustment Date", 
and including any extension options), the Base Rent shall be adjusted to 
equal the product of the Base Rent in effect for the calendar month 
immediately preceding the Rent Adjustment Date multiplied by a fraction, the 
numerator of which is the Consumer Price Index published for the month 
immediately preceding the Rent Adjustment Date in question and the 
denominator of which is the Consumer Price Index published for the month 
immediately preceding the Commencement Date (with respect to the first rent 
adjustment) or the immediately preceding Rent Adjustment Date (with respect 
to each other rent adjustment); provided, however, that in no event shall the 
Base Rent on a Rent Adjustment Date be less than one hundred two percent 
(102%), nor more than one hundred six percent (106%) of the Base Rent due for 
the immediately preceding period.  The term "Consumer Price Index" shall mean 
the Consumer Price Index, for All Urban Consumers, Subgroup "All Items", for 
the San Francisco-Oakland-San Jose Metropolitan Area (Base Year 1982-84=100), 
which is currently being published by the United States Department of Labor, 
Bureau of Labor Statistics.  If, however, this Consumer Price Index is 
changed so that the base year is altered from that used as of the 
Commencement Date, then the Consumer Price Index shall be converted in 
accordance with the conversion factor published by the United States 
Department of Labor, Bureau of Labor Statistics, to obtain the same results 
that would have been obtained had the base year not been changed.  If no 
conversion factor is available or if the Consumer Price Index is otherwise 
changed, revised or discontinued for any reason, there shall be substituted 
in lieu thereof and the term "Consumer Price Index" shall thereafter refer to 
the most nearly comparable official price index of the United States 
Government to obtain substantially the same result as would have been 
obtained had the original Consumer Price Index not been changed, revised or 
discontinued, which alternative index shall be selected by Lessor and shall 
be subject to Lessee's approval, which approval will not be unreasonably 
withheld or delayed. 

    9. OPTION TO RENEW.  Lessee shall have the option (the "Option") to 
extend the Lease Term for an additional term of thirty-six (36) months, 
commencing when the initial Lease Term expires, upon the terms and conditions 
set forth in this paragraph.  Lessee may exercise such option only by giving 
Lessor written notice of its intention on or before the one hundred eightieth 
day (180th) day prior to the end of the initial Lease Term.   Notwithstanding 
the foregoing, if either (i) Lessee is in default under the Lease (beyond any 
applicable cure period) on the date that Lessee gives its written Option 
notice to Lessor, (ii) Lessee is in default under the Lease (beyond any 
applicable cure period) on the date the Option term is to commence, or (iii) 
Lessor fails to receive a written Option notice from Lessee on or before the 
expiration of the foregoing 180-day time period, then the Option term shall 
not commence, any such Option notice given by Lessee shall be deemed 
ineffective, and the Lease shall expire at the end of the initial Lease Term. 
If the Option is timely and properly exercised, Base Rent during the Option 
term shall be the Base Rent for the initial Lease Term as adjusted under 
Section 8 of this Addendum.  All other terms and conditions contained in the 
Lease, as the same may be amended from time to time by the parties in 
accordance with the provisions of the Lease, shall remain in full force and 
effect and shall apply during the Option term.

    10. APPROVALS.  Whenever the Lease requires an approval, consent, 
designation, determination, selection or judgment by either Lessor or Lessee, 
such approval, consent, designation, determination, selection or judgment and 
any conditions imposed thereby shall, except as otherwise expressly set forth 
in the Lease Form, be reasonable and shall not be unreasonably withheld or 
delayed and, in exercising any right or remedy hereunder, each party shall at 
all times act reasonably and in good faith. 

    11. REAL PROPERTY TAXES.  Lessee shall not be required to pay any portion 
of any tax or assessment expense in excess of the amount which would be 
payable if such tax or assessment expense were paid in installments over the 
longest possible term.  

                                      -2-

<PAGE>


    12. ASSIGNMENT AND SUBLETTING.  For the purpose of the Lease, any private 
or public offering of Lessee's capital stock shall not be deemed an 
assignment, subletting or other transfer of the Lease or the Premises 
requiring Lessor's consent.

    13. EFFECT OF ADDENDUM.  In the event of any inconsistency between this 
Addendum and the Lease, the terms of this Addendum shall prevail.  

    IN WITNESS WHEREOF, the parties have executed this Addendum.

LESSOR:                              LESSEE:
- -------                              -------

R&S, LLC,                            QUARK BIOTECH, INC., a California 
limited liability company            a California corporation


By                                   By
  ------------------------------        -------------------------------
Name                                 Name
    ----------------------------           ----------------------------
Its                                  Its
   -----------------------------          -----------------------------
Dated                                Dated
     ---------------------------           ----------------------------


                                      -3-

<PAGE>

                                  SCHEDULE 1

                      Hazardous Substances Questionnaire

Address of Subject Property:               1059 Serpentine Lane,
                                           ---------------------
                                           Pleasanton, CA (the "Subject
                                           ----------------------------
                                           Property")
                                           ----------

Proposed Use of Subject Property:          Laboratory & Office
                                           -----------------------------

GENERAL INSTRUCTIONS:  Please provide information as it relates to your past 
uses and proposed use of Hazardous Substances at the Subject Property.  If 
there is insufficient space, please attach a separate page as needed.  We 
appreciate your assistance.

   List the person who completed this questionnaire and who will be
   available for questions concerning this questionnaire.

   Name:  ROBERT W. LOGAN
        --------------------------------------------------------
   Position:  ACTING CONTROLLER
            ----------------------------------------------------
   Company Name:  QUARK BIOTECH, INC.
                ------------------------------------------------
   Address:  1059 SERPENTINE LANE
           -----------------------------------------------------
   Telephone #:
               -------------------------------------------------
   Date:  Nov. 2, 1997
        --------------------------------------------------------
- ------------------------------------------------------------------------------
1. GENERAL DESCRIPTION OF OPERATIONS:

  *1.1  Please describe on Schedule 1 (attached) the general nature 
        of the business and specific activities that will be conducted at the 
        Subject Property.

  *1.2  Please identify the person responsible for environmental compliance 
        and the length of time that person has held the position.

2. HAZARDOUS SUBSTANCES PRODUCTION AND USAGE:

  *2.1  Will your company use, store or manufacture Hazardous
        Substances at the Subject Property? "Hazardous Substances" means any 
        substance or any material containing such a substance that could be 
        considered toxic or hazardous under federal or state law including
        solvents, petroleum, pesticides, paints, asbestos containing materials,
        lead based batteries, radioactive materials and PCB containing 
        transformers.

        Yes   _______    No  ________

  *2.2  If the answer to 2.1 was yes, please list on attached Schedule 1 all 
        Hazardous Substances that will be used, stored or manufactured at the 
        Subject Property and the quantities of each.

3. HAZARDOUS SUBSTANCES STORAGE:

  *3.1  Will Hazardous Substances be stored at the Subject Property?

        Yes   _______    No  ________

  *3.2  If the answer to 3.1 was yes, please indicate the proposed 
        location of each storage area within the Subject Property by 
        attaching a floor plan.

  *3.3  Please identify the proposed locations within the Subject Property 
        of any storage lockers, underground tanks, sumps, storage 
        cabinets, etc.


                           *SEE ATTACHED RESPONSE

                                     -1-

<PAGE>


4. WASTES AND EMISSIONS:

   4.1  Has the company at any previous location ever discharged waste to any 
        body of water or stream or to any sanitation system or otherwise been 
        required to obtain a NPDES Permit or any other permit or approval from
        a governmental agency concerning waste water discharges?

        Yes   _______    No  ___X____

   4.2  Has the company at any previous location ever emitted any air 
        contaminant (including, but not limited to, reactive hydrocarbons, 
        sulfur oxides, carbon monoxide, nitrogen oxides, lead, particulate 
        matter, beryllium, mercury, asbestos, vinyl chloride, benzene, and 
        radionuclides) or has it ever been required to obtain an air 
        emissions permit or other permit or approval from a governmental
        agency concerning air emissions in order to conduct its business?

        Yes   _______    No  ___X____

   4.3  Has the company in the past transported waste off-site for disposal?

        Yes   _______    No  ___X____

        If the answer is yes, please describe the circumstances of the 
        disposal and the site to which the waste was taken. Please also 
        indicate whether a permit was required in order to dispose of the 
        waste or if further remediation was necessary before the waste was 
        disposed of.

   4.4  Has the company in the past transported waste off-site for recycling?

        Yes   _______    No  ___X____

   4.5  Does the company currently possess any permits or approvals from a 
        governmental agency with respect to its Hazardous Substances 
        activities?

        Yes   _______    No  ___X____

        If the answer is yes, please indicate the permits you currently 
        possess.

  *4.6  Does the company require any permit or approval not presently in full
        force and effect from any governmental agency in order to conduct its 
        Hazardous Substances activities?

        Yes   _______    No  ________


                           *SEE ATTACHED RESPONSE

                                      -2-

<PAGE>


5. REPORTING REQUIREMENTS:

   5.1  Has the company received notice that any of its operations or 
        facilities are subject to the Air Toxics Hot Spot Act or any other 
        law?

        Yes   _______    No  ___X____

   5.2  Has any of the company's previous operations fallen within the 
        reporting requirements for emissions, discharges or inventory pursuant
        to Title III of SARA or any other law?

        Yes   _______    No  ___X____

   5.3  Has the company filed a Hazardous Substances Management Plan? If so, 
        please attach a copy of the plan to this questionnaire.

        Yes   _______    No  ___X____

   5.4  Has the company ever notified employees of the presence of Hazardous 
        Substances at the work place? If so, please attach a copy of the 
        notice.

        Yes   _______    No  ___X____

The above information is accurate and current as of the below referenced date.

        Company Name:  QUARK BIOTECH, INC.
                      --------------------------------------------
                      By:  /s/ ROBERT W. LOGAN
                          ----------------------------------
                              (Signature)

                              ROBERT W. LOGAN
                          ---------------------------------------
                              (Type/Print Name)

                              ACTING CONTROLLER
                          ---------------------------------------
                              (Title)

                      Date:  Nov. 2, 1997
                            --------------------------------


                                        -3-


<PAGE>

                               QUARK BIOTECH, INC.
                Responses to Hazardous Substances Questionnaire
                               November 2, 1997

Response to question 1.1
     The Company is engaged in the research and development of diagnostic and 
therapeutic products utilizing gene discovery techniques and protein 
expression technologies.

Response to questions 1.2, 2.1, 2.2, 3.1, 3.2, 3.3, and 4.6
     The Company has not completed the development of its scientific plan for 
operations in the United States at this time. Accordingly, neither the 
staffing, equipment or chemical requirements have been defined to date and 
the Company is unable to definitively answer these questions at this time.


<PAGE>


                                SCHEDULE 1

                        DESCRIPTION OF ACTIVITIES



       Subject Property Address:               1059 Serpentine Lane,
                                               Pleasanton, CA


1.  GENERAL DESCRIPTION OF OPERATIONS:

    A. THE ACTIVITIES THAT WILL BE CONDUCTED AT THE SUBJECT PROPERTY WILL BE:

    B. THE PRODUCTS THAT WILL BE PRODUCED OR ASSEMBLED AT THE SUBJECT 
       PROPERTY ARE:

                                            BRIEFLY DESCRIBE ASSEMBLY OR
          PRODUCT DESCRIPTION                  MANUFACTURING PROCESS
          -------------------               -----------------------------




2.  HAZARDOUS SUBSTANCES THAT WILL BE USED, STORED OR MANUFACTURED AT THE 
    SUBJECT PROPERTY ARE:




3.  FLOOR PLAN OF THE SUBJECT PROPERTY AND PROPOSED HAZARDOUS SUBSTANCES 
    STORAGE AREAS:




4.  WASTE STREAMS:

    AIR EMISSIONS:     SOURCE(S)    VOLUME EMITTED      CONTROL DEVICES
    -------------      ---------    --------------      ----------------


    WATER DISCHARGE:   SOURCE(S)    CONSTITUENTS        PRETREATMENT
    ----------------   ---------    --------------      ----------------


    SOLID WASTE:       SOURCE(S)    CONSTITUENTS        DISPOSAL METHOD
    -------------      ---------    --------------      ----------------




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