SUPERGEN INC
POS EX, 1999-05-26
PHARMACEUTICAL PREPARATIONS
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<PAGE>


     As filed with the Securities and Exchange Commission on May 26, 1999

                                                      Registration No. 333-70505
- --------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                           ---------------------------

                         POST-EFFECTIVE AMENDMENT NO. 1
                                       TO
                                    FORM S-3

                             REGISTRATION STATEMENT

                                      UNDER
                           THE SECURITIES ACT OF 1933

                           ---------------------------

                                 SUPERGEN, INC.

             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)

                           ---------------------------

<TABLE>
<S>                              <C>                           <C>
            DELAWARE                        2834                    91-1841574
(STATE OR OTHER JURISDICTION OF  (PRIMARY STANDARD INDUSTRIAL    (I.R.S. EMPLOYER
 INCORPORATION OR ORGANIZATION)   CLASSIFICATION CODE NUMBER)  IDENTIFICATION NUMBER)
</TABLE>


                           TWO ANNABEL LANE, SUITE 220
                           SAN RAMON, CALIFORNIA 94583
                                 (925) 327-0200
   (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF
                    REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)

                           ---------------------------

                                JOSEPH RUBINFELD
                               PRESIDENT AND CHIEF
                                EXECUTIVE OFFICER
                                 SUPERGEN, INC.
                           TWO ANNABEL LANE, SUITE 220
                           SAN RAMON, CALIFORNIA 94583
                                 (925) 327-0200
    (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA
                           CODE, OF AGENT FOR SERVICE)

                           ---------------------------

                                   COPIES TO:
                               JOHN V. ROOS, ESQ.
                        WILSON SONSINI GOODRICH & ROSATI
                            PROFESSIONAL CORPORATION
                               650 PAGE MILL ROAD
                            PALO ALTO, CA 94304-1050
                                 (650) 493-9300

                           ---------------------------

     Approximate date of commencement of proposed sale to the public: FROM TIME
TO TIME AFTER THE EFFECTIVE DATE OF THIS REGISTRATION STATEMENT.

     If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, check the following box.
|_|


     If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box. |_|


     If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. |_|

     If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective statement for the same
offering. |_|

     If delivery of the prospectus is expected to be made pursuant to
Rule 434, please check the following box.  |_|

                           ---------------------------


                                 EXPLANATORY NOTE

      This Post-Effective Amendment No. 1 (the "Amendment") to the
Registration Statement on Form S-3 (File No. 333-70505) of SuperGen, Inc.
(the "Registration Statement") is being filed pursuant to Rule 462(d) under
the Securities Act of 1933, as amended, for the sole purpose of amending
certain exhibits previously filed with the Registration Statement and/or
filing additional exhibits and accordingly, shall become effective
immediately upon filing with the Securities and Exchange Commission (the
"Commission"). After giving effect to this Amendment, the Registration
Statement consists of the Registration Statement as filed with the
Commisssion at the time it became effective on May 20, 1999, as supplemented
by this Amendment.


<PAGE>




ITEM 16.  EXHIBITS.


      EXHIBIT
       NUMBER        DESCRIPTION OF DOCUMENT
       ------        -----------------------

        3.1        Certificate of Incorporation of the Registrant (1)
        3.2        Bylaws, as amended, of the Registrant (2)
        5.1        Opinion of Wilson Sonsini Goodrich & Rosati, P.C.**
       23.1        Consent of Ernst & Young LLP, Independent Auditors*
       23.2        Consent of Counsel (included in Exhibit 5.1)**
       24.1        Power of Attorney*

- ---------------------------

*    Previously filed exhibit.
**   Filed herewith.


(1)  Incorporated by reference from the Registrant's Proxy Statement filed with
     the Securities and Exchange Commission on April 25, 1997.

(2)  Incorporated by reference from the Registrant's Report on Form 10-K filed
     with the Securities and Exchange Commission on March 19, 1998.


                                      II-1

<PAGE>


                                   SIGNATURES


      Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-3 and has duly caused this
Post-Effective Amendment No. 1 to the Registration Statement to be signed on
its behalf by the undersigned, thereunto duly authorized, in the city of San
Ramon, state of California, on May 26, 1999.


                                        SUPERGEN, INC.

                                        By:  /s/ Joseph Rubinfeld
                                             ---------------------------
                                             Joseph Rubinfeld
                                             CHIEF EXECUTIVE OFFICER,
                                             PRESIDENT AND DIRECTOR

         Pursuant to the requirements of the Securities Act of 1933, this
Amendment No. 1 to the Registration Statement has been signed below by the
following persons in the capacities and on the dates indicated.


<TABLE>
<CAPTION>
         SIGNATURE                              Title                                 Date
<S>                                <C>                                            <C>
By: /s/ Joseph Rubinfeld           Chief Executive Officer, President             May 26, 1999
- ----------------------------       and Director (Principal Executive,
     Joseph Rubinfeld              Financial and Accounting Officer)


By:            *                   Director                                       May 26, 1999
- ----------------------------
     Denis Burger

By:                                Director                                       May 26, 1999
- ----------------------------
     Lawrence J. Ellison

By:                                Director                                       May 26, 1999
- ----------------------------
     Julius Vida

By:            *                   Director                                       May 26, 1999
- ----------------------------
     Daniel Zurr

*By: /s/Joseph Rubinfeld
- ----------------------------
     Joseph Rubinfeld
     Attorney-in-fact
</TABLE>


                                      II-2
<PAGE>

                                INDEX TO EXHIBITS


   EXHIBIT
    NUMBER        DESCRIPTION OF DOCUMENT
    ------        -----------------------

     3.1          Certificate of Incorporation of the Registrant (1)
     3.2          Bylaws, as amended, of the Registrant (2)
     5.1          Opinion of Wilson Sonsini Goodrich & Rosati, P.C.**
    23.1          Consent of Ernst & Young LLP, Independent Auditors*
    23.2          Consent of Counsel (included in Exhibit 5.1)**
    24.1          Power of Attorney*

- ---------------------------

*     Previously filed exhibit.
**    Filed herewith


(1)   Incorporated by reference from the Registrant's Proxy Statement filed with
      the Securities and Exchange Commission on April 25, 1997.

(2)   Incorporated by reference from the Registrant's Report on Form 10-K filed
      with the Securities and Exchange Commission on March 19, 1998.


                                      II-3

<PAGE>
                                                                   EXHIBIT 5.1


                                  May 26, 1999


SuperGen, Inc.
Two Annabel Lane, Suite 220
San Ramon, CA  94583

Ladies and Gentlemen:

     We have acted as counsel for SuperGen, Inc. (the "Company") which we
understand has filed with the Securities and Exchange Commission a
registration statement on Form S-3 (the "Registration Statement") that
relates to the issuance of $10,400,000 of common stock of the Company (that
is, 1,000,000 shares of common stock) (the "Shares").  We further understand
that the Shares will be issued and sold pursuant to resolutions of the Board
of Directors of the Company passed on May 25, 1999 (the "Resolutions").

     We have examined such documents, records and matters of law as we have
deemed necessary to the rendering of the following opinion.  We have assumed
the genuineness of all signatures, the legal capacity of all individuals and
the authenticity of all such documents submitted to us as originals and the
conformity to authentic original documents of all documents submitted to us
as certified, conformed or photostatic copies or facsimiles thereof.

     Based and relying upon and subject to the foregoing, we are of the
opinion that upon receipt of payment in full therefor in accordance with the
Resolutions, the Shares will be validly issued, fully paid and non-assessable.

     We hereby consent to the use of this opinion as an exhibit to the
Registration Statement and further consent to the use of our name wherever it
appears in the Registration Statement, including the prospectus constituting
a part thereof, and any amendments thereto.

                                      Very truly yours,

                                      WILSON SONSINI GOODRICH & ROSATI
                                      Professional Corporation

                                      /s/ Wilson Sonsini Goodrich & Rosati




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