SUPERGEN INC
POS EX, 1999-06-07
PHARMACEUTICAL PREPARATIONS
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<PAGE>

    As filed with the Securities and Exchange Commission on June 7, 1999
                                                     Registration No. 333-70505
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- -------------------------------------------------------------------------------

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                             ----------------------
                         POST-EFFECTIVE AMENDMENT NO. 2
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                             ----------------------
                                 SUPERGEN, INC.
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
                             ----------------------
         DELAWARE                      2834                    91-1841574
      (STATE OR OTHER            (PRIMARY STANDARD          (I.R.S. EMPLOYER
      JURISDICTION OF               INDUSTRIAL           IDENTIFICATION NUMBER)
     INCORPORATION OR           CLASSIFICATION CODE
       ORGANIZATION)                  NUMBER)

                          TWO ANNABEL LANE, SUITE 220
                          SAN RAMON, CALIFORNIA 94583
                                 (925) 327-0200
   (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER, INCLUDING AREA CODE, OF
                    REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)
                             ----------------------
                                JOSEPH RUBINFELD
                   PRESIDENT AND CHIEF EXECUTIVE OFFICER
                                 SUPERGEN, INC.
                           TWO ANNABEL LANE, SUITE 220
                           SAN RAMON, CALIFORNIA 94583
                                 (925) 327-0200
            (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER,
                   INCLUDING AREA CODE, OF AGENT FOR SERVICE)
                             ----------------------
                                   COPIES TO:
                               JOHN V. ROOS, ESQ.
                       WILSON SONSINI GOODRICH & ROSATI
                            PROFESSIONAL CORPORATION
                               650 PAGE MILL ROAD
                            PALO ALTO, CA 94304-1050
                                 (650) 493-9300
                             ----------------------

     Approximate date of commencement of proposed sale to the public:  FROM
TIME TO TIME AFTER THE EFFECTIVE DATE OF THIS REGISTRATION STATEMENT.

     If the only securities being registered on this Form are being offered
pursuant to dividend or interest reinvestment plans, check the following
box. / /

     If any of the securities being registered on this Form are to be offered
on a delayed or continuous basis pursuant to Rule 415 under the Securities
Act of 1933, other than securities offered only in connection with dividend
or interest reinvestment plans, check the following box.  / /

     If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following
box and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering.  / /

     If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective statement for the same
offering.  / /

     If delivery of the prospectus is expected to be made pursuant to Rule
434, please check the following box.  / /

                             ----------------------

                                EXPLANATORY NOTE

     This Post-Effective Amendment No.2 (the "Amendment") to the Registration
Statement on Form S-3 (File No. 333-70505) of SuperGen, Inc. (the
"Registration Statement") is being filed pursuant to Rule 462(d) under the
Securities Act of 1933, as amended, for the sole purpose of amending certain
exhibits previously filed with the Registration Statement and/or filing
additional exhibits and accordingly, shall become effective immediately upon
filing with the Securities and Exchange Commission (the "Commission").  After
giving effect to this Amendment, the Registration Statement consists of the
Registration Statement as filed with the Commission at the time it became
effective on May 20, 1999, as supplemented by this Amendment.
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<PAGE>


                                       PART II
                        INFORMATION NOT REQUIRED IN PROSPECTUS

ITEM 16.  EXHIBITS.

<TABLE>
<CAPTION>
    EXHIBIT
    NUMBER    DESCRIPTION OF DOCUMENT
    ------    -----------------------
    <S>       <C>
    3.1       Certificate of Incorporation of the Registrant (1)
    3.2       Bylaws, as amended, of the Registrant (2)
    5.1       Opinion of Wilson Sonsini Goodrich & Rosati, P.C.**
   23.1       Consent of Ernst & Young LLP, Independent Auditors*
   23.2       Consent of Counsel (included in Exhibit 5.1)**
   24.1       Power of Attorney*
</TABLE>
- --------------
*    Previously filed exhibit.

**   Filed herewith.

(1)  Incorporated by reference from the Registrant's Proxy Statement filed with
     the Securities and Exchange Commission on April 25, 1997.

(2)  Incorporated by reference from the Registrant's Report on Form 10-K filed
     with the Securities and Exchange Commission on March 19, 1998.


                                      II-1
<PAGE>


                                      SIGNATURES

     Pursuant to the requirements of the Securities Act of 1933, the
Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-3 and has duly caused this
Post-Effective Amendment No. 2 to the Registration Statement to be signed on
its behalf by the undersigned, thereunto duly authorized, in the city of San
Ramon, State of California, on June 7, 1999.

                                   SUPERGEN, INC.
                                   By:  /s/ Joseph Rubinfeld
                                      -------------------------------
                                        Joseph Rubinfeld
                                        CHIEF EXECUTIVE OFFICER,
                                        PRESIDENT AND DIRECTOR


     Pursuant to the requirements of the Securities Act of 1933, this
Post-Effective Amendment No. 2 to the Registration Statement has been signed
below by the following persons in the capacities and on the dates indicated.

<TABLE>
<CAPTION>
          SIGNATURE                         TITLE                      DATE
          ---------                         -----                      ----
 <S>                         <C>                                   <C>
 By: /s/ Joseph Rubinfeld    Chief Executive Officer, President    June 7, 1999
    ----------------------   and Director (Principal Executive,
    Joseph Rubinfeld         Financial and Accounting Officer)

 By:    *                    Director                              June 7, 1999
    ----------------------
    Denis Burger

 By:                         Director                              June 7, 1999
    ----------------------
    Lawrence J. Ellison

 By:                         Director                              June 7, 1999
    ----------------------
    Julius Vida

 By:    *                    Director                              June 7, 1999
    ----------------------
    Daniel Zurr

 *By: /s/ Joseph Rubinfeld
    ----------------------
     Joseph Rubinfeld
     Attorney-in-fact
</TABLE>

                                      II-2
<PAGE>


                                  INDEX TO EXHIBITS


<TABLE>
<CAPTION>
   EXHIBIT
   NUMBER    DESCRIPTION OF DOCUMENT
   ------    -----------------------
   <S>       <C>
      3.1    Certificate of Incorporation of the Registrant (1)
      3.2    Bylaws, as amended, of the Registrant (2)
      5.1    Opinion of Wilson Sonsini Goodrich & Rosati, P.C.**
     23.1    Consent of Ernst & Young LLP, Independent Auditors*
     23.2    Consent of Counsel (included in Exhibit 5.1)**
     24.1    Power of Attorney*
</TABLE>
- --------------
*    Previously filed exhibit.

**   Filed herewith.

(1)  Incorporated by reference from the Registrant's Proxy Statement filed with
     the Securities and Exchange Commission on April 25, 1997.

(2)  Incorporated by reference from the Registrant's Report on Form 10-K filed
     with the Securities and Exchange Commission on March 19, 1998.


                                      II-3




<PAGE>
                                                                    EXHIBIT 5.1


                                June 7, 1999


SuperGen, Inc.
Two Annabel Lane, Suite 220
San Ramon, CA  94583

Ladies and Gentlemen:

     We have acted as counsel for SuperGen, Inc. (the "Company") which we
understand has filed with the Securities and Exchange Commission a
registration statement on Form S-3 (the "Registration Statement") that
relates to the issuance of $2,080,000 of common stock of the Company (that
is, 200,000 shares of common stock) (the "Shares").  We further understand
that the Shares will be issued and sold pursuant to resolutions of the Board
of Directors of the Company passed on June 3, 1999 (the "Resolutions").

     We have examined such documents, records and matters of law as we have
deemed necessary to the rendering of the following opinion.  We have assumed
the genuineness of all signatures, the legal capacity of all individuals and
the authenticity of all such documents submitted to us as originals and the
conformity to authentic original documents of all documents submitted to us
as certified, conformed or photostatic copies or facsimiles thereof.

     Based and relying upon and subject to the foregoing, we are of the
opinion that upon receipt of payment in full therefor in accordance with the
Resolutions, the Shares will be validly issued, fully paid and non-assessable.

     We hereby consent to the use of this opinion as an exhibit to the
Registration Statement and further consent to the use of our name wherever it
appears in the Registration Statement, including the prospectus constituting
a part thereof, and any amendments thereto.

                                        Very truly yours,

                                        WILSON SONSINI GOODRICH & ROSATI
                                        Professional Corporation

                                        /s/ Wilson Sonsini Goodrich & Rosati



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