HEMASURE INC
DEF 14A, 1999-05-24
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
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                                  SCHEDULE 14A

                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant [X]

Filed by a Party other than the Registrant [ ]

Check the appropriate box:
[ ] Preliminary  Proxy Statement
[ ] Confidential, for Use of the Commission Only
    (as permitted by Rule  14a-6(e)(2))
[X] Definitive  Proxy Statement
[ ] Definitive  Additional  Materials
[ ] Soliciting Material Pursuant to Section 240.14a-11(c) or Section 240.14a-12

                                  HemaSure Inc.
- --------------------------------------------------------------------------------

                (Name of Registrant as Specified In Its Charter)

- --------------------------------------------------------------------------------

    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[X]   No fee required.
[  ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

      1) Title of each class of securities to which transaction applies:

         -----------------------------------------------------------------------

      2) Aggregate number of securities to which transaction applies:

         -----------------------------------------------------------------------

      3) Per unit price or other underlying value of transaction computed
         pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
         filing fee is calculated and state how it was determined):

         -----------------------------------------------------------------------

      4) Proposed maximum aggregate value of transaction:

         -----------------------------------------------------------------------

      5) Total fee paid:

         -----------------------------------------------------------------------

[  ]     Fee paid previously with preliminary materials.

[  ]     Check box if any part of the fee is offset as  provided by Exchange
         Act Rule  0-11(a)(2) and identify the filing for which the offsetting
         fee was paid previously. Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.

      1) Amount Previously Paid:

         -----------------------------------------------------------------------

      2) Form, Schedule or Registration Statement No.:

         -----------------------------------------------------------------------

      3) Filing Party:

         -----------------------------------------------------------------------

      4) Date Filed:

         -----------------------------------------------------------------------

825592.5

<PAGE>



                                  HEMASURE INC.
                                 140 Locke Drive
                        Marlborough, Massachusetts 01752

                  NOTICE OF 1999 ANNUAL MEETING OF STOCKHOLDERS

                           To Be Held on June 10, 1999

           The 1999  Annual  Meeting  of  Stockholders  of  HemaSure  Inc.  (the
"Company") will be held at the Holiday Inn, Marlborough, Massachusetts 01752, on
Thursday,  June 10, 1999 at 10:00 a.m., local time, to consider and act upon the
following matters:

           1. To elect seven directors to serve until the next Annual Meeting
              of Stockholders.

           2. To  approve  and  adopt  an  amendment  to the  Company's  1995
              Employee  Stock Purchase Plan to increase the number of authorized
              shares  of  common  stock  issuable  thereunder  from  250,000  to
              500,000.

           3. To approve and adopt certain  amendments to the Company's  1994
              Stock Option Plan.

           4. To consider and act upon a proposal to amend the Certificate of
              Incorporation  of the Company to increase the number of authorized
              shares of common stock from 20,000,000 to 35,000,000.

           5. To transact such other business as may properly come before the
              meeting or any adjournment thereof.

           Stockholders of record at the close of business on April 28, 1999 are
entitled to notice of, and to vote at, the meeting.  The stock transfer books of
the Company will remain open for the purchase and sale of the  Company's  common
stock, par value $.01 per share.

           All stockholders are cordially invited to attend the meeting.

                                          By Order of the Board of Directors



                                          JAMES B. MURPHY, Secretary

Marlborough, Massachusetts
May 24, 1999


           WHETHER  OR NOT YOU EXPECT TO ATTEND THE  MEETING,  PLEASE  COMPLETE,
DATE AND SIGN THE  ENCLOSED  PROXY  CARD AND  PROMPTLY  MAIL IT IN THE  ENCLOSED
ENVELOPE IN ORDER TO ASSURE  REPRESENTATION  OF YOUR SHARES AT THE  MEETING.  NO
POSTAGE NEED BE AFFIXED IF THE PROXY CARD IS MAILED IN THE UNITED STATES.

825592.5

<PAGE>



                                  HEMASURE INC.
                                 140 Locke Drive
                        Marlborough, Massachusetts 01752

           Proxy Statement for the 1999 Annual Meeting of Stockholders

                           To Be Held on June 10, 1999

           This Proxy Statement is furnished in connection with the solicitation
of proxies by the Board of Directors of HemaSure Inc. (the "Company") for use at
the 1999 Annual Meeting of  Stockholders  to be held on June 10, 1999 and at any
adjournment or adjournments of that meeting (the "Annual Meeting").  All proxies
will be voted in accordance with the instructions  contained therein,  and if no
choice is specified, the proxies will be voted in favor of the matters set forth
in the accompanying Notice of Meeting. Any proxy may be revoked by a stockholder
at any time before it is  exercised  by delivery  of written  revocation  to the
Secretary of the Company.

           The Company's  Annual Report for the year ended December 31, 1998, is
being  mailed to  stockholders  with the  mailing of this  Notice of Meeting and
Proxy Statement on or about May 24, 1999.

Voting Securities and Votes Required

           On  April  28,  1999,  the  record  date  for  the  determination  of
stockholders  entitled  to  notice  of and to vote at the  meeting,  there  were
outstanding  and entitled to vote an aggregate  of  10,421,071  shares of common
stock of the Company,  par value $.01 per share ("Common Stock").  Each share of
Common Stock is entitled to one vote.

           Under the Company's  Bylaws,  the holders of a majority of the shares
of Common  Stock  issued,  outstanding  and entitled to vote on any matter shall
constitute  a  quorum  with  respect  to  that  matter  at the  Annual  Meeting.
Stockholders  holding  shares  of  Common  Stock  who are  present  in person or
represented  by proxy  (including  stockholders  who abstain  from voting  their
shares or who do not vote with  respect to one or more of the matters  presented
for stockholder  approval) will be counted for purposes of determining whether a
quorum is present.

           The  affirmative  vote of the holders of a plurality of votes cast by
the  stockholders  entitled to vote at the Annual  Meeting is  required  for the
election of directors.  The  affirmative  vote of a majority of the  outstanding
stock entitled to vote thereon,  and a majority of the outstanding stock of each
class  entitled  to vote  thereon as a class is  required  in order to amend the
certificate of incorporation.  The affirmative vote of the holders of a majority
of the shares of Common  Stock voting on the matter is required for the approval
of each of the other matters to be voted upon.

           Stockholders who abstain from voting as to a particular  matter,  and
shares  held in "street  name" by  brokers or  nominees  who  indicate  on their
proxies that they do not have discretionary  authority to vote such shares as to
a particular  matter,  will not be counted as votes in favor of such matter, and
will  also not be  counted  as  votes  cast or  shares  voting  on such  matter.
Accordingly,  abstentions  and  "broker  non-votes"  will  have no effect on the
voting on a matter that requires the affirmative vote of a certain percentage of
the votes cast or shares voting on a matter.


825592.5


<PAGE>



Stock Ownership of Certain Beneficial Owners and Management

           The following table sets forth certain information, as of January 31,
1999, with respect to any person (including any "group," as that term is used in
Section  13(d)(3)  of the  Securities  Exchange  Act of 1934,  as  amended  (the
"Exchange  Act")) who is known to the Company to be the beneficial owner of more
than five percent of any class of the  Company's  voting  securities,  and as to
those shares of the Company's equity  securities  beneficially  owned by each of
its directors and nominees for director,  the executive  officers of the Company
named in the  Summary  Compensation  Table under the  heading  "Compensation  of
Executive  Officers" below, and all of its directors and executive officers as a
group.  Unless otherwise  specified in the table below, such information,  other
than information  with respect to the directors and officers of the Company,  is
based on a review of statements  filed, or that should have been filed, with the
Securities and Exchange  Commission pursuant to Sections 13(d), 13(f), and 13(g)
of the Exchange Act with respect to the Company's  Common  Stock.  As of January
31, 1999, there were 9,087,737 shares of Common Stock outstanding.  As of May 7,
1999, there were 14,921,071  shares of Common Stock  outstanding.  See footnotes
(1) and (2) below.

           The  number  of shares of  Common  Stock  beneficially  owned by each
person is determined  under the rules of the Commission,  and the information is
not necessarily  indicative of beneficial ownership for any other purpose. Under
such rules, beneficial ownership includes any shares as to which such person has
sole or shared  voting power or  investment  power and also any shares which the
individual  has the right to  acquire  within 60 days  after  January  31,  1999
through  the  exercise  of any stock  option or other  right.  Unless  otherwise
indicated,  each  person has sole  investment  and voting  power (or shares such
power  with his or her  spouse)  with  respect  to the  shares  set forth in the
following table. The inclusion  herein of any shares deemed  beneficially  owned
does not constitute an admission of beneficial ownership of those shares. Unless
otherwise specified, the address for each person below is c/o HemaSure Inc., 140
Locke Drive, Marlborough, Massachusetts 01752.


<TABLE>
<CAPTION>
                                                                                 Shares of                   Percentage of
                                                                                Common Stock                     Common
                                                                                Beneficially                     Stock
                               Name and Address                                   Owned(1)                   Outstanding(1)
                               ----------------                                   --------                   --------------
<S>                                                                              <C>                             <C>
Sepracor Inc..................................................................   4,700,000(2)                    43.6%(2)
           111 Locke Drive
           Marlborough, MA 01752
Novo Nordisk A/S(3)...........................................................     827,375                        9.1%
           405 Lexington Avenue
           Suite 6400
           New York, NY 10017-6401
Morgens, Waterfall, Vintiadis & CO., Inc.                                          500,000                        5.5%
           10 East 50th Street
           New York, NY 10022
Nicholas Madonia, Trustee(4)..................................................     489,000                        5.4%
           Madonia, Pilles & Co., P.A.
           30 Outwater Lane
           Garfield, NJ  07026



825592.5
                                       -2-

<PAGE>


                                                                                 Shares of                   Percentage of
                                                                                Common Stock                     Common
                                                                                Beneficially                     Stock
                               Name and Address                                   Owned(1)                   Outstanding(1)
                               ----------------                                   --------                   --------------

Timothy J. Barberich(5)....................................................... 116,750                           1.3%
John F. McGuire...............................................................  230,000                          2.5%
David S. Barlow(6)............................................................   34,125                             *
Rolf S. Stutz(6)..............................................................   37,125                             *
Justin E. Doheny..............................................................      700                             *
Peter C. Sutcliffe............................................................   30,351                             *
James B. Murphy...............................................................   30,090                             *
Edward C. Wood(7).............................................................     0(1)                          *(1)
Frank Corbin(7)...............................................................     0(1)                          *(1)
All directors and executive officers as a group
(persons)(8)..................................................................  479,141                          5.0%
</TABLE>

- ---------------
*          Represents holdings of less than one percent.

(1)        Amounts and percentages  reflected exclude 4,500,000 shares of Common
           Stock issued by the Company to COBE  Laboratories,  Inc.  ("COBE") on
           May 3, 1999; such shares were issued to COBE subsequent to the record
           date for the Company's 1999 Annual Meeting and are not eligible to be
           voted in respect to the matters set forth herein.  As of May 7, 1999,
           COBE  beneficially  owned   approximately   30.2%  of  the  Company's
           outstanding  Common  Stock.  See "Certain  Relationships  and Related
           Transactions - COBE" below. COBE's principal business address is 1201
           Oak Street, Lakewood, CO. 80215-4498.

(2)        Includes  1,700,000  shares of Common  Stock which  Sepracor  has the
           right to acquire  within 60 days after January 30, 1999 upon exercise
           of outstanding warrants. Excludes 1,333,334 shares of Common Stock of
           the Company and immediately  exercisable warrants to purchase 667,000
           shares of Common  Stock of the  Company  which,  in each  case,  were
           acquired by Sepracor  on March 23,  1999 and which,  when  aggregated
           with the 4,700,000 shares  beneficially  owned as of January 31, 1999
           as set forth above,  result in Sepracor  beneficially owning 38.8% of
           the shares of Common Stock outstanding as of May 7, 1999.

(3)        On January 16, 1998, the Company  converted all indebtedness  under a
           convertible  subordinated promissory note issued to Novo Nordisk A/S,
           pursuant  to the terms  thereof,  into  shares  of Common  Stock at a
           conversion price of $10.50 per share.  Novo Nordisk A/S has contested
           the conversion of the note,  including the  forgiveness of $3 million
           of indebtedness pursuant to the terms thereof.


825592.5
                                       -3-

<PAGE>



(4)        Mr.  Madonia is the trustee for three  trusts  (the  "Trusts")  which
           collectively  hold 489,000 shares of Common Stock. In accordance with
           the terms of the Trusts'  governing  documents,  Mr.  Madonia has the
           sole  power to vote and sole power to dispose of the shares of Common
           Stock  held  by the  trustee.  Each  of the  Trusts  is a  charitable
           remainder  trust  in  accordance   with  the  applicable   rules  and
           regulations of the Internal Revenue Code of 1986, as amended.

(5)        Includes 87,750 shares of Common Stock which Mr. Barberich has
           the right to acquire within 60 days after January 31, 1999 upon
           exercise of outstanding stock options.

(6)        Includes  31,125 shares of Common Stock which each of Messrs.  Barlow
           and Stutz has the right to acquire  within 60 days after  January 31,
           1999 upon exercise of outstanding stock options.

(7)        Messrs. Wood and Corbin are the President and Vice President of R&D
           of COBE BCT, Inc. a division of COBE. See footnote (1) above.

(8)        Includes  an  aggregate  of  405,000  shares  of Common  Stock  which
           executive  officers and directors have the right to acquire within 60
           days after  January  31,  1999 upon  exercise  of  outstanding  stock
           options.


                              ELECTION OF DIRECTORS

           The  persons  named  in the  enclosed  proxy  will  vote to  elect as
directors the seven nominees named below,  unless the proxy is marked otherwise.
If a stockholder  returns a proxy  without  contrary  instructions,  the persons
named as proxies will vote to elect as directors the nominees named below,  each
of whom is currently a member of the Board of Directors of the Company.

           Each  director  will be elected to hold office  until the 2000 Annual
Meeting of  Stockholders  and until his successor is duly elected and qualified.
All of the nominees  have  indicated  their  willingness  to serve,  if elected;
however,  if any nominee  should be unable to serve,  the shares of Common Stock
represented by proxies may be voted for a substitute  nominee  designated by the
Board of Directors.

           There are no family  relationships  between or among any  officers or
directors of the Company.

           Set forth  below are the name and age of each  member  of, or nominee
to, the Board of  Directors,  and the  positions  and offices  held by him,  his
principal  occupation and business  experience  during the past five years,  the
names of other  publicly held companies of which he serves as a director and the
year of the  commencement of his term as a director of the Company.  Information
with respect to the number of shares of Common Stock  beneficially owned by each
director,  directly or indirectly,  as of January 31, 1999,  appears above under
the heading "Stock Ownership of Certain Beneficial Owners and Management."

                              Nominees For Director

           Timothy J. Barberich,  age 51, has served as Chairman of the Board of
the Company since April 1997, as a director since the Company's  organization in
1993 and was Chairman of the Board of Directors  from 1993 until March 1996. Mr.
Barberich   was  a  founder  of   Sepracor   Inc.   ("Sepracor"),   a  specialty
pharmaceutical company, and has served as President, Chief Executive Officer and
a director of Sepracor  since 1984.  As of January 31, 1999 and May 7, 1999
Sepracor owned approximately 43.6% and

825592.5
                                       -4-

<PAGE>



38.8%,  respectively,  of the  outstanding  Common  Stock  of the  Company.  Mr.
Barberich  also serves as Chairman of the board of directors of BioSepra Inc., a
publicly   traded   subsidiary  of  Sepracor   engaged  in  the  manufacture  of
instrumentation and media for the pharmaceutical industry.

           David S.  Barlow,  age 42, has served as a  director  of the  Company
since January 1994.  Mr. Barlow has been Executive Vice President and President,
Pharmaceuticals  Division  of Sepracor  since  October  1995.  From July 1993 to
October 1995,  Mr. Barlow held the position of Senior Vice President and General
Manager of the Pharmaceuticals  Division of Sepracor.  From 1991 to 1993, he was
president of the Business Group, a management  consulting firm.  Previously,  he
was Vice  President,  Worldwide  Marketing  and Business  Development  of Armour
Pharmaceutical Company, a subsidiary of Rhone-Poulenc Rorer, from 1988 to 1991.
Prior to that time, he was associated with Pfizer Inc. and Ares-Serono,  Inc. in
various business planning and marketing positions.

           Rolf S. Stutz,  age 49, has served as a director of the Company since
January 1994.  Mr. Stutz has been Chairman  (since June 1996),  Chief  Executive
Officer  (since 1983) and a director of Zoll  Medical  Corporation  ("Zoll"),  a
manufacturer of  cardiovascular  monitoring and treatment  equipment.  He served
previously as President of Zoll from 1983 to June 1996.  From 1979 to 1983,  Mr.
Stutz held a variety of domestic and  international  management  positions  with
Millipore Corporation, an industrial filtration manufacturer.  Mr. Stutz is also
a director of Cambridge  Heart,  Inc., a  corporation  engaged in the  research,
development,  and  commercialization  of products for non-invasive  diagnosis of
cardiac disease.

           John F. McGuire,  age 52, has served as Chief Executive Officer and a
director of the Company since April 1997. Prior to that time, Mr. McGuire served
as Vice  President  and  General  Manager of Johnson & Johnson's  ("J&J")  Ortho
Diagnostic  Systems Blood Bank Business Unit since January 1996. From March 1995
to January  1996,  Mr.  McGuire  held the  position of Vice  President,  Sales &
Marketing,  North America for J&J. From August 1990 to March 1995,  Mr.  McGuire
served as Managing  Director of Ortho Diagnostic  Systems,  U.K. and Belgium for
J&J.  From  September  1988 to August  1990,  Mr.  McGuire  held the position of
Marketing Director for the AIDS and Hepatitis Business Unit of J&J. From 1977 to
1988, Mr. McGuire held various management  positions at E.I. DuPont De Nemours &
Company,  the  last of  which  was  National  Sales  Manager,  AIDS &  Hepatitis
Business. Mr. McGuire is a member of the Board of Trustees of the National Blood
Foundation Trust Fund and of the Bergen Community Blood Center.

           Justin E. Doheny, age 47, has been Executive Vice President and Chief
Operating Officer of Saint Peter's University Hospital, New Brunswick, NJ, since
August  1997.  During  1996  (June-October),  Mr.  Doheny  served as Senior Vice
President of Saint Barnabas Health Care System in Livingston,  NJ. From December
1985 until June 1996, Mr. Doheny held the position of President of Wayne General
Hospital, located in Wayne, NJ.

           Edward C.  Wood,  age 54, has been  President  of COBE BCT,  Inc.,  a
division of COBE  Laboratories,  Inc. since 1991. COBE is a subsidiary of Gambro
AB, a Swedish company,  and is a leading provider of blood separation  products.
Prior to that, Mr. Wood held various  positions in  manufacturing,  research and
development  and  marketing  with  COBE.  He  served  on the  Board  of  Aastrom
Biosciences,  Inc.  from  August 1994 until  February  1999.  Mr. Wood  received
degrees in  chemistry  from  Harvey  Mudd  College  and in  management  from the
University of Colorado.

           Frank  Corbin,  age 52,  has been  Vice  President  of  Research  and
Development of COBE BCT, Inc.  since July 1997.  Prior to that Mr. Corbin served
as Director of Research and  Development  for COBE BCT,  Inc.  from January 1991
until  July  1997.  Mr.  Corbin  received a  Bachelor  of  Science  degree  from
Northwestern University.

Board and Committee Meetings

           The Company has a standing Audit Committee of the Board of Directors,
which  provides  the  opportunity  for  direct  contact  between  the  Company's
independent  accountants  and the Board of  Directors.  The Audit  Committee has
responsibility for recommending the appointment of the Company's independent

825592.5
                                       -5-

<PAGE>


accountants,  reviewing  the  scope and  results  of audits  and  reviewing  the
Company's  internal  accounting  control  policies  and  procedures.  The  Audit
Committee met once in 1998.  In 1998,  the members of the Audit  Committee  were
Messrs. Doheny and Stutz.

           The Company also has a standing  Compensation  Committee of the Board
of Directors, which provides recommendations to the Board of Directors regarding
compensation programs of the Company. The Compensation  Committee is responsible
for establishing and modifying the compensation of all corporate officers of the
Company,  adoption and amendment of all stock option and other employee  benefit
plans,   and  the  engagement  of,  terms  of  any  employment   agreements  and
arrangements with, and termination of, all corporate officers of the Company. In
1998, the members of the Compensation  Committee were Messrs.  Stutz and Doheny.
See "Report of the Compensation Committee" below.

           The  Company  does not have a  nominating  committee  or a  committee
serving a similar  function.  Nominations are made by and through the full Board
of Directors.

           The Board of Directors held six meetings  during 1998. Each director,
other than Mr. Doheny who is addressed below, attended at least 75% of the total
number of  meetings  (including  consents in lieu of  meetings)  of the Board of
Directors.  Mr.  Doheny  attended  at least 75% of the total  number of meetings
(including  consents in lieu of meetings)  of the Board of Directors  which took
place during the period of his directorship.

Compensation for Directors

           Directors who are neither officers nor employees of the Company or of
any subsidiary of the Company (the "Outside  Directors") receive $1,000 for each
meeting  of the  Board  they  attend  and are  entitled  to  participate  in the
Company's  1994  Director  Stock Option Plan, as amended (the  "Director  Option
Plan"),  provided that Mr. Barberich and Mr. Barlow do not receive  compensation
for attendance at meetings of the Board. Directors who are officers or employees
of the Company do not receive any additional  compensation for their services as
directors. On January 5, 1994, options to purchase an aggregate of 75,000 shares
of Common Stock at an exercise  price of $2.00 per share were granted  under the
Director Option Plan to the following directors:  Mr. Barberich,  45,000 shares,
and Mr. Barlow,  Mr. Stutz, and two former members of the Board (Messrs.  Tullis
and  Kimbell)  7,500 shares each.  On May 17,  1995,  options to purchase  1,500
shares of Common  Stock at an  exercise  price of $5.50 per share  were  granted
under the Director Option Plan to the following  directors:  Mr. Barberich,  Mr.
Barlow,  Mr.  Stutz and two  former  members  of the Board  (Messrs.  Tullis and
Kimbell).  On February 15,  1996,  options to purchase  18,750  shares of Common
Stock at an  exercise  price of $12.375  per share were  granted  under the 1994
Stock  Option Plan to Mr.  Barberich.  On May 16,  1996,  options to purchase an
aggregate of 39,000  shares of Common  Stock at an exercise  price of $16.25 per
share were granted under the Director  Option Plan to the  following  directors:
Mr. Barberich, Mr. Barlow, Mr. Kimbell, and Mr. Stutz, 9,750 shares each. On May
16, 1997,  options to purchase an aggregate of 12,000  shares of Common Stock at
an exercise price of $1.75 per share were granted under the Director Option Plan
to the following  directors:  Mr.  Barberich,  Mr.  Barlow,  Mr. Kimbell and Mr.
Stutz,  3,000 shares each. On January 22, 1998, options to purchase an aggregate
of 162,000 shares of Common Stock, at an exercise price of $0.625,  were granted
under the 1994 Stock  Option Plan to the  following  directors:  Mr.  Barberich,
75,000  shares,  and Messrs.  Barlow and Stutz,  43,500  shares each. On May 26,
1998,  options to purchase an aggregate  of 16,500  shares of Common Stock at an
exercise price of $1.50 per share were granted under the Director Option Plan to
the following directors:  Mr. Barberich,  Mr. Barlow, and Mr. Stutz 3,000 shares
each and Mr. Doheny, 7,500 shares.


825592.5
                                       -6-

<PAGE>



                      EXECUTIVE OFFICERS OF THE REGISTRANT

           The following  table sets forth the names,  ages and positions of the
current executive officers of the Company.

<TABLE>
<CAPTION>
                     Name                             Age                          Position
                    -----                            ----                         ----------
<S>                                                     <C>         <C>
John F. McGuire.....................................    52          President, Chief Executive Officer and Director

James B. Murphy.....................................    42          Senior Vice President, Finance and Administration
                                                                    Treasurer and Secretary

Peter Sutcliffe.....................................    49          Vice President and Chief Operating Officer
</TABLE>

          Mr. McGuire's biography is set forth under "Election of Directors --
Nominees for Director."

          Mr. Murphy has served as Senior Vice President, Finance and
Administration since February 1996. From April 1994 to January 1996, he served
as Vice President and Corporate Controller of the Company. Prior to that, from
1990 to April 1994, he served as Corporate Controller of Sepracor. Previously,
Mr. Murphy held the positions of Senior Corporate Accountant at BBN Inc. and
Senior Accountant at Arthur Andersen LLP.

          Mr. Sutcliffe has served as Chief Operating Officer of the Company
since April 3, 1998. From May 1996 until that time, Mr. Sutcliffe served as Vice
President of Manufacturing Operations of the Company. From May 1982 until May
1996, Mr. Sutcliffe held the position of Vice President Manufacturing for
Corning Costar Incorporated. From 1976 until 1982, he was a plant manufacturing
manager at Millipore Corporation.

Compensation of Executive Officers

          Summary Compensation Table. The following table sets forth certain
information with respect to the annual and long-term compensation for the last
three fiscal years of the Company's President and Chief Executive Officer and
the Company's other executive officers (including former executive officers)
whose total annual salary and bonus for 1998 exceeded $100,000 (collectively,
the "Named Executive Officers").


825592.5
                                       -7-

<PAGE>



                           SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                                                  Long-Term
                                                                                                Compensation
                                                             Annual Compensation                    Awards
                                                             -------------------                -------------         All
                                                                               Other Annual      Securities          Other
                                                                               Compensation      Underlying      Compensation
     Name and Principal Position       Year            Salary ($)    Bonus($)     ($)(1)        Options/SARs        ($)(2)
     ---------------------------       ----            ----------    --------    --------      --------------    ------------
<S>                                    <C>               <C>         <C>          <C>             <C>                    <C>
John F. McGuire......................  1998              $216,172         -       -               800,000 (3)            300
     President and                     1997               140,302    75,000       -               600,000                195
     Chief Executive Officer           1996                     -         -       -                     -                  -

James B. Murphy......................  1998              $140,063         -       -               220,000 (4)          $  63
     Senior Vice President             1997               119,387                                  60,000                222
     Finance and Administration        1996               112,926         -       -                30,000                247

Peter C. Sutcliffe...................  1998              $160,125         -       -               200,000 (4)           $125
                                       1997               143,005         -       -                     -                112
                                       1996               116,141    25,000       -                     -                 91
</TABLE>
- -------------

(1)        Other  compensation  in the form of  perquisites  and other  personal
           benefits  has been  omitted if such  perquisites  and other  personal
           benefits  constituted  less than the  lesser of $50,000 or 10% of the
           total salary and bonus for the Named Executive Officer.

(2)        Represents  the taxable  portion of group life insurance paid by
           the Company.

(3)        Includes  600,000  repriced  options.  See  "Ten-Year  Option/SAR
           Repricings" table below.

(4)        Includes  100,000  repriced  options.  See  "Ten-Year  Option/SAR
           Repricings" table below.


           Option  Grant  Table.   The   following   table  sets  forth  certain
information regarding options granted during the year ended December 31, 1998 by
the Company to the Named Executive Officers.


                         OPTION/SAR GRANTS IN LAST YEAR
<TABLE>
<CAPTION>

                                     Individual Grants
                                     -----------------
                                                Percent of                   Market
                                                   Total                    Price of
                                 Number of       Options/                  Securities                   Potential Realizable Value
                                Securities         SARs         Exercise   Underlying                   as Assumed Annual Rates of
                                Underlying      Granted to         or       Options/                     Stock Price Appreciation
                               Options/SARs    Employees In       Base        SARs                          For Option Term(2)
                                  Granted         Fiscal          Price     On Grant   Expiration      ---------------------------
            Name                  (#)(1)           Year          ($/sh)       Date        Date            5%($)            10%($)
            ----                  ------           ----          ------       ----        ----         -----------     -----------

<S>                              <C>             <C>           <C>          <C>         <C>             <C>              <C>
John F. McGuire..............    800,000         43.0600       $0.6250      $0.6250     1-22-08        $ 314,447          $796,871


James B. Murphy..............    120,000          6.4592       $0.6250      $0.6250     1-22-08        $  47,167          $119,531
                                 100,000          5.3826        1.2500       1.2500     6-30-08           78,612           199,218


Peter C. Sutcliffe...........    100,000          5.3826       $0.6250      $0.6250     1-22-08        $  39,306          $ 99,609
                                 100,000          5.3826        1.2500       1.2500     6-30-08           78,612           199,218
</TABLE>
- ---------------

(1)         Options vest in up to five equal annual  installments  beginning
            on the first anniversary of the date of grant.

(2)         Amounts  represent  hypothetical  gains that could be  achieved  for
            options if exercised  and sold at the end of the option term.  These
            gains are based on assumed rates of stock price  appreciation  of 5%
            and 10%  compounded  annually  from the date  options  are  granted.
            Actual gains,  if any, on stock option  exercises will depend on the
            future  performance  of the  Common  Stock on the date on which  the
            options are sold.

825592.5
                                       -8-

<PAGE>




            Year-End  Option  Table.  The  following  table sets  forth  certain
information  regarding  options  held  as of  December  31,  1998  by the  Named
Executive Officers. No Named Executive Officer exercised stock options in 1998.

                AGGREGATED OPTION/SAR EXERCISES IN LAST YEAR AND
                           YEAR-END OPTION/SAR VALUES


<TABLE>
<CAPTION>
                                                                               Number of
                                                                              Securities
                                                                              Underlying               Value of Unexercised
                                                                              Unexercised                  In-The-Money
                                                                            Options/SARs at               Options/SARs at
                                                                          Fiscal Year-End (#)         Fiscal Year-End ($)(1)
                                                                          -------------------         ----------------------
                                      Shares
                                   Acquired on           Value              Exercisable/                  Exercisable/
                   Name            Exercise (#)       Realized ($)         Unexercisable(2)                Unexercisable
                   ----            ------------       ------------         ----------------                -------------
<S>                                <C>                <C>                     <C>                           <C>
John F. McGuire..................                                              0/800,000                     0/849,600
James B. Murphy..................                                              0/220,000                     0/171,140
Peter C. Sutcliffe...............                                              0/200,000                     0/149,900
</TABLE>
- ---------------

(1)   Value is based on the closing sales price of the Company's Common Stock on
      December 31, 1998  ($1.6870),  the last trading day of the Company's  1998
      fiscal year, less the applicable option exercise price.


           Option  Repricing  Table.  The table set forth below provides certain
information  concerning all  adjustments  to the exercise  prices of outstanding
stock  options  held by  executive  officers of the  Company  during the past 10
years.

                         TEN-YEAR OPTION/SAR REPRICINGS

<TABLE>
<CAPTION>
                                                  Number of
                                                  Securities  Market Price     Exercise                          Length of Original
                                                  Underlying   of Stock at     Price at                              Option Term
                                                 Options/SARs    Time of       Time of                            Remaining at Date
                                                 Repriced or  Repricing or   Repricing or          New             of Repricing or
            Name                   Date            Amended      Amendment     Amendment      Exercise Price       Amendment (years)
                                   ----            -------      ---------     ---------      --------------       -----------------
<S>                               <C>              <C>           <C>        <C>                 <C>                 <C>
John F. McGuire..............     1/22/98          600,000       $0.6250    $  2.5630           $0.6250             9

James B. Murphy..............     4/16/97           12,000       $3.5000    $  7.5000           $3.5000            10
                                  4/16/97           30,000       $3.5000    $ 12.3800           $3.5000            10
                                  1/22/98          120,000       $0.6250    $  3.5000           $0.6250             9

Peter C. Sutcliffe...........     4/16/97           25,000       $3.5000    $ 14.3750           $3.5000             9
                                  1/22/98          100,000       $0.6250    $  3.5000           $0.6250             9
</TABLE>




825592.5
                                       -9-

<PAGE>



Report of the Compensation Committee

           The  Compensation  Committee  of the  Board  of  Directors,  which is
currently comprised of two non-employee  directors,  Rolf S. Stutz and Justin E.
Doheny,  is  responsible  for  determining  the  compensation  package  of  each
executive   officer  and  recommending  it  to  the  Board  of  Directors.   The
Compensation   Committee  sets  the  compensation  for  executive  officers  and
establishes  compensation policies for the Company's Chief Executive Officer and
the other executive  officers of the Company.  All decisions by the Compensation
Committee are reviewed by the Board of Directors.

           The Company's executive  compensation  program is designed to promote
the  achievement of the Company's  business  goals,  and,  thereby,  to maximize
corporate performance and stockholder returns.  Executive  compensation consists
of a combination of base salary and  stock-based  incentives.  The  Compensation
Committee   considers  stock  incentives  to  be  a  critical  component  of  an
executive's compensation package in order to help align executive interests with
stockholder interests.

           Compensation Philosophy

           The  objective  of the  executive  compensation  program is to align
compensation with business objectives and individual performance,  and to enable
the Company to attract, retain and reward executive officers who are expected to
contribute to the  long-term  success of the Company.  The  Company's  executive
compensation  philosophy  is based on the  principles  of  competitive  and fair
compensation and sustained performance.

           o         Competitive and Fair Compensation
                     The  Company  is   committed   to  providing  an  executive
                     compensation  program that helps  attract and retain highly
                     qualified  executives.   To  ensure  that  compensation  is
                     competitive,   the  Company   compares   its   compensation
                     practices with those of other companies in the industry and
                     sets its compensation  guidelines based on this review. The
                     Company believes compensation for its executive officers is
                     within the range of  compensation  paid to executives  with
                     comparable qualifications,  experience and responsibilities
                     in the same or similar  businesses  and of comparable  size
                     and success.  The Company also strives to achieve equitable
                     relationships  both among the  compensation  of  individual
                     officers and between the compensation of officers and other
                     employees throughout the organization.

           o         Sustained Performance
                     Executive   officers  are  rewarded  based  upon  corporate
                     performance   and   individual    performance.    Corporate
                     performance  is evaluated by reviewing  the extent to which
                     strategic and business plan goals are met,  including  such
                     factors  as  achievement  of  operating   budgets,   timely
                     development  and commercial  introduction  of new processes
                     and  products,  establishment  of strategic  licensing  and
                     development  alliances  with third parties and  performance
                     relative  to   competitors.   Individual   performance   is
                     evaluated by reviewing  attainment of specified  individual
                     objectives  and the degree to which  teamwork  and  Company
                     values are fostered.

           In  evaluating  each  executive  officer's  performance,  the Company
generally conforms to the following process:

           o         Company  and   individual   goals  and   objectives  are
                     established at the beginning of the performance cycle.
           o         At the end of the performance cycle, the  accomplishments
                     of  the   executive's   goals   and   objectives   and  his
                     contributions to the Company are evaluated.

825592.5
                                      -10-

<PAGE>



           o         The  executive's  performance  is then  compared with peers
                     within the Company and the results are  communicated to the
                     executive.
           o         The   comparative   results,   combined  with   comparative
                     compensation  practices of other companies in the industry,
                     are then used to  determine  salary and stock  compensation
                     levels.

           Annual compensation for the Company's  executives  generally consists
of a base salary and from time to time,  the Committee may consider the granting
of stock  options and the payment of cash bonuses  based upon  performance  in a
particular year.

           The salary for executives is generally set by reviewing  compensation
for competitive  positions in the market and the historical  compensation levels
of the executives.  Increases in annual  salaries are based on actual  corporate
and individual  performance against targeted  performance and various subjective
performance  criteria.  Targeted  performance  criteria vary for each  executive
based  on his  area  of  responsibility,  and  may  include  achievement  of the
operating  budget  for the  Company  as a whole  or of a  business  group of the
Company,  continued  innovation  in  development  and  commercialization  of the
Company's   technology   and  products,   timely   development   and  commercial
introduction  of  new  products  or  processes,   implementation   of  financing
strategies and  establishment of strategic  licensing and development  alliances
with third  parties.  Subjective  performance  criteria  include an  executive's
ability to motivate others.  develop the skills necessary to grow as the Company
matures,  recognize and pursue new business  opportunities and initiate programs
to enhance  the  Company's  growth and  success.  The  Committee  does not use a
specific  formula based on these targeted  performance and subjective  criteria,
but instead makes an evaluation of each  executive  officer's  contributions  in
light of all such criteria.

           Compensation  at  the  executive  officer  level  also  includes  the
long-term  incentives  afforded by stock  options.  The stock option  program is
designed to promote the identity of long-term  interests  between the  Company's
employees and its  shareholders  and assist in the retention of executives.  The
size of option grants is generally intended to reflect the executive's  position
with the Company and his contributions to the Company,  including his success in
achieving  the  individual  performance  criteria  described  above.  The option
program  generally  uses a vesting  period of up to five years to encourage  key
employees to continue in the employ of the Company. All stock options granted to
executive  officers  in 1998 were  granted at fair  market  value on the date of
grant.  During 1998,  all  executive  officers  received  options to purchase an
aggregate of 400,000  shares of Common  Stock,  at a weighted  average  exercise
price of $.9375 per share.  In addition  options to purchase  820,000  shares of
Common Stock were repriced with an exercise price of $.6250.

           Executive  officers are also eligible to participate in the Company's
1995  Employee  Stock  Purchase  Plan,  as amended (the  "Purchase  Plan").  The
Purchase  Plan is  available  to  virtually  all  employees  of the  Company and
generally permits  participants to purchase shares of Common Stock at a discount
of  approximately  15% from the fair market value at the beginning or end of the
applicable purchase period.

             Base Salaries

           The base  salaries of the Named  Executive  Officers have been set by
reviewing   compensation  for  competitive  positions  in  the  market  and  the
historical  compensation  levels of such executives.  The employment  agreements
with the Named  Executive  Officers  are  described  more fully  under  "Certain
Relationship and Related Transactions."

           Compliance with Internal Revenue Code Section 162(m)

           Section 162(m) of the Internal  Revenue Code of 1986, as amended (the
"Code"),  enacted  in  1993,  generally  disallows  a tax  deduction  to  public
companies for compensation over $1 million paid to the

825592.5
                                      -11-

<PAGE>



corporation's  Chief  Executive  Officer and four other most highly  compensated
executive officers.  Qualifying performance  compensation will not be subject to
the  deduction  limit if certain  requirements  are met. The Company  intends to
structure the  performance-based  portion of the  compensation  of its executive
officers (which currently  consists of stock option grants and performance based
bonuses  described  above),  in a manner that  complies  with the new statute to
mitigate any disallowance of deductions.

           Repricing of Options

           THE FOLLOWING  SECTION OF THIS PROXY STATEMENT SHALL NOT BE DEEMED TO
BE  INCORPORATED  BY REFERENCE INTO ANY FILING BY THE COMPANY WITH THE SEC UNDER
THE SECURITIES ACT OF 1933, AS AMENDED,  OR THE SECURITIES EXCHANGE ACT OF 1934,
AS AMENDED,  NOTWITHSTANDING  ANY SUCH  INCORPORATION  BY REFERENCE OF ANY OTHER
PORTIONS OF THIS PROXY STATEMENT.

           On January 22, 1998, the Compensation  Committee authorized a program
pursuant  to  which the Company  offered to holders  certain  "out-of-the-money"
stock options issued under the Company's 1994 Stock Option Plan, as amended (the
"Plan"),  the right to surrender those options for  cancellation in exchange for
new options  exercisable at $0.625 per share, which was the fair value per share
of Common Stock on January 22, 1998. Each new option is exercisable for the same
number  of  shares  as the  canceled  option  for  which it was  exchanged,  and
generally  follows the same type of vesting and  expiration  schedules,  but the
vesting and  expiration  schedules  begin on the new grant date.  The  Committee
believes that this exchange program was in the best interests of the Company and
was  necessary  in order for the Plan to  continue  serving  one of its  primary
purposes  - to  encourage  key  employees  to  remain  with the  Company  and to
contribute  toward efforts to increase the value of the Company's  Common Stock.
Prior  to  their   cancellation   pursuant   to  the   exchange   program,   the
out-of-the-money  options had exercise prices ranging from $2.00 to $12.38,  and
therefore provided little incentive to employees.

                             Compensation Committee

                             Rolf S. Stutz
                             Justin E. Doheny


Compensation Committee Interlocks and Insider Participation

           The current members of the  Compensation  Committee are Mr. Stutz and
Mr.  Doheny.  Neither Mr. Stutz nor Mr.  Doheny were at any time during 1998, or
formerly,  an officer  or  employee  of the  Company  or any  subsidiary  of the
Company,  nor has any member of the Compensation  Committee had any relationship
with the Company requiring disclosure under Item 404 of Regulation S-K under the
Exchange Act.

           No  executive  officer of the  Company  has  served as a director  or
member of the Compensation  Committee (or other committee  serving an equivalent
function)  of any other  entity,  one of whose  executive  officers  served as a
director of or member of the Compensation Committee of the Company.

Comparative Stock Performance

           The comparative stock performance graph below compares the cumulative
stockholder  return on the Common Stock of the Company for the period from April
7, 1994  through  the year ended  December  31, 1998 with the  cumulative  total
return on (i) the CRSP Total  Return  Index for The  Nasdaq  Stock  Market  (the
"Nasdaq Composite Index"),  and (ii) the Nasdaq  Pharmaceutical  Index (assuming
the

825592.5
                                      -12-

<PAGE>



investment of $100 in the Company's Common Stock (at the initial public offering
price), the Nasdaq Composite Index and the Nasdaq  Pharmaceutical Index on April
7, 1994 and reinvestment of all dividends).

           Measurement  points are on April 7, 1994 and the last  trading day of
the years ended  December  31,  1994,  December  31,  1995,  December  31, 1996,
December 31, 1997 and December 31, 1998.










                               [Graphics Omitted]















Certain Relationships and Related Transactions

           Sepracor.  The Company was organized in December 1993 as a subsidiary
of  Sepracor.   Effective  January  1,  1994,  Sepracor  transferred  its  blood
filtration  and membrane  filter design  business to the Company in exchange for
3,000,000  shares  of  Common  Stock.  As of  January  31,  1999 and May 7, 1999
Sepracor beneficially owned approximately 43.6% and 38.8%, respectively,  of the
Company's outstanding Common Stock. Messrs.  Barberich and Barlow,  directors of
the Company,  are  President  and Chief  Executive  Officer and  Executive  Vice
President and President, Pharmaceuticals Division, respectively, of Sepracor.

           In September 1998, the Company  completed a $5 million revolving line
of credit  arrangement with a commercial bank.  Sepracor,  the Company's largest
shareholder  has guaranteed to repay amounts  borrowed under the line of credit.
In  exchange  for the  guarantee,  the Company  granted to Sepracor  warrants to
purchase up to  1,700,000  shares of the  Company's  common  stock at a price of
$0.69 per share.  The  warrants  will  expire in the year 2003 and have  certain
registration  rights associated with them. In March 1999,  Sepracor purchased an
additional  1,333,334  shares of Common Stock of the Company for $1.50 per share
and in connection  therewith received warrants to purchase an additional 667,000
shares at a price of $1.50 per share and certain  registration rights in respect
of such acquired securities.


825592.5
                                      -13-

<PAGE>


           Employment  and  Retention  Agreements.  The Company  entered into an
employment  agreement,  as of April 1,  1997  (the  "Agreement"),  with  John F.
McGuire which provides that Mr.  McGuire serve as President and Chief  Executive
Officer of the  Company.  The  Agreement  provided  for a first  year  salary of
$14,583  per  month  and an  annual  bonus  of  $75,000  to be  earned  upon the
achievement  of certain goals as  determined by the Board of Directors,  and for
adjustments thereto in subsequent years, as determined by the Board of Directors
or its  Compensation  Committee.  Upon execution of the  Agreement,  Mr. McGuire
received an option to  purchase  600,000  shares of Common  Stock at an exercise
price equal to the "low" bid price for the Common  Stock as quoted on the Nasdaq
National  Market System for the week of April 4, 1997.  The options vest in four
equal annual  installments  commencing in 1998.  Pursuant to the  Agreement,  an
additional  200,000  incentive  stock  options  were  issued to Mr.  McGuire  in
January, 1998. Finally,  pursuant to the terms of the Agreement,  if Mr. McGuire
is terminated  other than for cause,  he will receive one year's salary plus the
bonus  payable for the prior year,  to be paid monthly over the course of the 12
months  following  such  termination,  or  until  he  secures  employment  in an
equivalent role.

           On December 15,  1998,  the Company  entered  into senior  management
retention Agreements (the "Retention Agreements"), with each of John F. McGuire,
James B. Murphy and Peter C. Sutcliff, (each individually a "Key Employee"),  to
reinforce  and  encourage  their  continued  attention  and  dedication to their
duties.  Pursuant to the Retention Agreements,  in the event a change of control
occurs (as defined in the  agreements) and the Key Employee (i) is terminated by
the Company  after the change of control,  (ii) remains  employed by the Company
for 12 months  after the change of control or (iii)  terminates  his  employment
with the  Company  for good cause,  then the Key  Employee  is eligible  for (i)
payment of his full base salary plus all amounts entitled under any compensation
plan through the termination date, (ii) severance payments,  payable in 24 equal
monthly  installments  equal to 200% (except for Mr.  McGuire who shall  receive
300%), of the higher of his annual base salary  immediately prior to the date of
termination  or his base  salary in effect  immediately  prior to the  change of
control and (iii) life, disability,  dental, accident and group health insurance
benefits  for a period  of 36  months  after  such  termination.  The  Retention
Agreements  are  automatically  renewed  each  year  unless  written  notice  of
termination is delivered by October 30th of any given year.

           COBE. Pursuant to a Stock Subscription Agreement,  dated May 3, 1999,
between the Company  and COBE,  (i) COBE  purchased  from the  Company,  and the
Company  issued  to COBE,  4,500,000  shares  of  Common  Stock at an  aggregate
purchase  price of $9 million  and (ii)  subject to  stockholder  approval,  the
Company  granted  COBE an option  (the "COBE  Option")  to acquire $3 million of
Common Stock at a per share price equal to the average  closing  price per share
of Common Stock for the thirty (30) trading day period  immediately prior to the
date of exercise of such  option.  The COBE  Option is  exercisable  at any time
after  August 2, 1999 and prior to May 3, 2000,  and is  subject to  stockholder
approval of the proposal to amend the Company's certificate of incorporation, as
set  forth in this  proxy  statement,  in order  that the  Company  will  have a
sufficient number of shares available for issuance upon the exercise thereof. In
connection  with the  foregoing  transaction,  the Company and COBE  amended and
restated their  pre-existing  Distribution  Agreement to expand the territory in
which  COBE  will  distribute  the  Company's  products  to make  it  worldwide,
excluding sales to the American Red Cross. In addition,  the agreement  provides
for joint  efforts  related to the  defense of the  Company's  products  against
intellectual property claims made by third parties.


           Novo Nordisk A/S. Under the terms of the May 1996 agreement  relating
to the Company's acquisition of the plasma product unit of Novo Nordisk A/S (the
"Denmark  Acquisition"),  the purchase  price to be paid for the plasma  product
unit was to be comprised of three portions:  (i) $1,800,000 was to be payable in
1998 in cash or common stock of the Company or a subsidiary  of the Company,  at
the Company's option; (ii) approximately $13,000,000 was to be payable from time
to  time  upon  the  sale  of  acquired   inventory   (valued  at  approximately
$13,000,000),  but  in any  event  no  later  than  1998,  provided  that  up to
approximately   $3,000,000   of  such  portion  could  be  forgiven  in  certain
circumstances;  and (iii)

825592.5
                                      -14-

<PAGE>


approximately  $8,000,000  was to be payable in 1998 in cash or Common  Stock of
the Company or a subsidiary of the Company,  at the Company's  option,  provided
that all of this portion would be forgiven in certain circumstances.  In January
1997,  the Company  and Novo  Nordisk  entered  into a  Restructuring  Agreement
relating to the Denmark Acquisition (the "Restructuring Agreement"). Pursuant to
the Restructuring Agreement,  approximately  $23,000,000 of indebtedness owed to
Novo Nordisk was  restructured by way of issuance by the Company to Novo Nordisk
of a 12% convertible  subordinated  promissory  note in the principal  amount of
approximately $11,722,000,  which was due and payable on December 31, 2001 (the
"Note"),  with interest  payable  quarterly  (provided that up to  approximately
$3,000,000 would be forgiven in certain circumstances). Approximately $8,500,000
of the  reduction  of such  indebtedness  was  forgiven.  The  remainder  of the
reduction  represented a net amount due from Novo Nordisk to the Company related
to various service arrangements  between the two companies.  On January 6, 1998,
the Company elected to convert all indebtedness under the Note,  pursuant to the
terms thereof,  into shares of Common Stock of the Company at a conversion price
equal to $10.50 per share, or 827,375 shares.  Pursuant to a registration rights
agreement,  the Company  previously  granted Novo Nordisk  certain  registration
rights with respect to any shares of Common Stock  acquired by Novo Nordisk upon
conversion of the Note.  Novo Nordisk has contested the  conversion of the Note,
including the forgiveness of the $3,000,000  amount.  The Company  believes such
claims are without merit.



825592.5
                                      -15-

<PAGE>


           APPROVAL OF AMENDMENTS TO 1995 EMPLOYEE STOCK PURCHASE PLAN

Summary of Amendment

           On April 2, 1999, the Company's Board of Directors  adopted,  subject
to  stockholder  approval,  an amendment to the Company's  1995  Employee  Stock
Purchase  Plan (as  amended,  the  "Amended  Purchase  Plan") to provide  for an
increase,  from 250,000 to 500,000, in the number of authorized shares of Common
Stock issuable under the Amended Purchase Plan. The Board of Directors  believes
that it is in the best  interest of the Company to continue to  encourage  stock
ownership by employees of the Company.

           The principal  provisions of the Amended Purchase Plan are summarized
below. The following summary of the material  provisions of the Amended Purchase
Plan does not purport to be complete  and is  qualified  in its  entirety by the
terms of the Amended  Purchase Plan. A copy of the Amended  Purchase Plan may be
obtained from the Company by contacting  James B. Murphy,  Senior Vice President
Finance and Administration, 140 Locke Drive, Marlborough, Massachusetts 01752.

The Amended Purchase Plan

           The  purpose of the  Amended  Purchase  Plan is to  provide  eligible
employees of the Company and certain of its subsidiaries  with  opportunities to
purchase shares of the Company's Common Stock.

           Administration. The Amended Purchase Plan will be administered by the
Company's  Board  of  Directors  or by a  committee  appointed  by the  Board of
Directors (the "Committee"),  whose construction and interpretation of the terms
and provisions of the Amended Purchase Plan shall be final and conclusive.

           Eligibility. With certain limited exceptions in the case of employees
already  holding a  significant  amount of Common  Stock,  each  employee of the
Company as of the date an offering  commences  and who  ordinarily  works twenty
(20) or more hours per week and more than five (5)  months per year is  eligible
to participate in the Amended  Purchase Plan. As of April 2,1999,  approximately
45 employees were eligible to participate in the Amended Purchase Plan.

           Offerings.  The Company will make one or more  offerings to employees
to purchase  stock under the Amended  Purchase  Plan.  Offerings will begin each
June 1 and  December 1, or the first  business  day  thereafter  (the  "Offering
Commencement  Date"). The Offering  Commencement Date will begin a six (6) month
period during which payroll deductions will be made and held for the purchase of
the  Company's  common  stock at the end of the  offering  period.  The Board of
Directors of the Committee may, at its discretion,  select a different period of
twelve (12) months or less for subsequent offerings,  as further detailed in the
Amended Purchase Plan.

           Participation  and Deductions.  An employee  eligible on the Offering
Commencement  Date may participate in an offering by completing and forwarding a
payroll  deduction  authorization  form at least  thirty  (30) days prior to the
applicable  Offering  Commencement  Date.  Payroll deductions may be made in one
(1%) percent increments from 1% to 10% of compensation (which excludes overtime,
incentive or bonus awards, allowances and reimbursements for expenses), with any
change in  compensation  during the  offering  period to result in an  automatic
corresponding change in the dollar amount withheld.  An employee may decrease or
discontinue his payroll  deduction once during the offering period,  by filing a
new payroll deduction authorization form. An employee may not, however, increase
his payroll deduction during the offering period. Unless an employee files a new
form or withdraws  from the Amended  Purchase Plan, his deductions and purchases
will continue at the same rate for future  offerings under the Amended  Purchase
Plan as long as the Amended Purchase Plan remains in effect.

825592.5
                                      -16-

<PAGE>



           No  employee  may be granted an option  which  permits  his rights to
purchase  the  Company's  Common Stock under the Amended  Purchase  Plan and any
other stock  purchase plan of the Company and its  subsidiaries,  to accrue at a
rate  which  exceeds  $25,000  of the fair  market  value of such  Common  Stock
(determined at the Offering  Commencement  Date of the offering period) for each
calendar year in which the option is outstanding at any time.

           Withdrawal  of Funds.  An employee may at any time prior to the close
of business on the last business day in an offering period,  and for any reason,
withdraw the funds  accumulated in the employee's  account and thereby  withdraw
from  participation  in the Amended Purchase Plan.  Partial  withdrawals are not
permitted.

           Purchase of Shares. On the Offering  Commencement Date of an offering
period,  the Company  will grant to each  participating  employee,  an option to
purchase,  on the last business day of such offering period, at the option price
provided for in the Amended  Purchase  Plan,  such number of whole shares of the
Company's Common Stock reserved for the purposes of the Amended Purchase Plan as
does not exceed the number of shares  determined by dividing six (6%) percent of
such employee's  annualized  compensation  for the  immediately  prior six-month
period by the price  determined in accordance  with the formula set forth in the
Amended Purchase Plan, but using the closing price on the Offering  Commencement
Date of such offering period.

           Each  employee  who  continues  to be a  participant  in the  Amended
Purchase  Plan  at the  end of the  offering  period  shall  be  deemed  to have
exercised his option at the  applicable  option price on such date, and shall be
deemed to have purchased  from the Company the applicable  number of full shares
of the Company's Common Stock. With minor  exceptions,  any balance remaining in
the employee's  payroll deduction account at the end of the offering period will
be automatically refunded to the employee.

           Issuance of Certificates.  Certificates representing shares of Common
Stock purchased  under the Amended  Purchase Plan may be issued only in the name
of the employee,  in the name of the employee and another person of legal age as
joint tenants with rights of survivorship, or (in the Company's sole discretion)
in the street name of a brokerage firm, bank or other nominee holder  designated
by the employee.

           Amendment   and   Termination.   Subject  to  the   approval  of  the
stockholders in certain  circumstances,  the Board of Directors may at any time,
and from time to time,  amend the Amended  Purchase Plan.  The Amended  Purchase
Plan may be terminated at any time by the Board of Directors.  Upon  termination
of the  Amended  Purchase  Plan,  all amounts in the  accounts of  participating
employees will be promptly refunded.

Federal Income Tax Consequences.

           The Amended  Purchase  Plan is  intended  to qualify as an  "employee
stock purchase plan" as defined in Section 423 of the Code,  which provides that
an employee does not have to pay any federal income tax when such employee joins
the Amended  Purchase  Plan,  or when an offering  period ends and such employee
receives  shares of the  Company's  Common  Stock.  The  employee  is,  however,
required  to pay a federal  income tax on the  difference,  if any,  between the
price at which he sells the shares and the price he or she paid for them.

           If an employee  has owned  shares for more than one year and disposes
of them at least two years after the date an offering period commenced,  he will
be taxed as described  below. If the market price of the shares on the date they
are sold is less than the price paid for the shares  under the Amended  Purchase
Plan,  the  employee  will incur a long term capital loss in the amount equal to
the price paid over

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                                      -17-

<PAGE>



the sale  price.  If the sale  price is  higher  than the price  paid  under the
Amended  Purchase Plan, such employee will have to recognize  ordinary income in
an amount  equal to the lesser of the market price of the shares on the date the
offering commenced over the price paid, or the excess of the sale price over the
price paid. Any further gain is treated as long-term capital gain. Except as set
forth below,  the Company will generally not be entitled to a tax deduction upon
the purchase or sale of shares under the Amended  Purchase Plan. If the employee
sells  the  shares  before  he or she has  owned  them for more than one year or
before the expiration of a two-year  period  commencing on the date the offering
period  commenced,  the employee will have to recognize  ordinary  income in the
amount of the  difference  between the option  price and the market price of the
shares on the date of purchase and the Company will receive an expense deduction
for the same amount.  The employee will recognize a capital gain or loss for the
difference  between the sale price and the market price on the date of purchase.
The gain or loss will be  long-term  if the  employee  owned the shares for more
than one year.

Board Recommendation

           The Board of Directors  believes the Amended  Purchase Plan is in the
best interests of the Company and its  stockholders  and therefore  recommends a
vote FOR this proposal.

825592.5
                                      -18-

<PAGE>



              APPROVAL OF AMENDMENTS TO THE 1994 STOCK OPTION PLAN

Summary of the Amendments

           On April 2, 1999, the Company's Board of Directors  adopted,  subject
to  stockholder  approval,  an amendment and  restatement  of the Company's 1994
Stock Option Plan (as amended,  the "Amended  Option  Plan") to (i)  incorporate
amendments  previously  adopted by the Board and  approved by the  stockholders,
(ii) make  certain  changes in light of  changes to Rule 16b under the  Exchange
Act, and (iii)  increase the number of shares  authorized for issuance under the
Amended Option Plan.

            The Board of Directors adopted a so-called "evergreen" limitation on
the number of shares of Common Stock that can be transferred with respect to the
grant of options made under the Amended  Option Plan (i.e.,  the Amended  Option
Plan  expresses  the  maximum  number of shares  which may be  transferred  with
respect to the grant of options in terms of a percentage of outstanding  shares)
to ensure that the Company can continue to grant options to employees,  officers
and  directors  of,  and  consultants  or  advisors  to,  the  Company at levels
determined  appropriate by the Board of Directors.  This type of limitation will
replenish the shares  available under the Amended Option Plan,  without the need
for further amendment, in the event there is an increase in the number of shares
the Company has  outstanding.  The  amendment  provides  for a pool of shares of
Common Stock  reserved and available for issuance  under the Amended Option Plan
equal to the greater of (i)  2,500,000  shares of Common Stock and (ii) eighteen
(18%) percent of the issued and outstanding  shares,  calculated  generally with
respect  to the  number  of shares  outstanding  as of the last day of the prior
calendar year (assuming all unexpired and outstanding options are exercised).

           The principal  provisions of the Amended  Option Plan are  summarized
below.  The following  summary of the material  provisions of the Amended Option
Plan does not purport to be complete  and is  qualified  in its  entirety by the
terms of the Amended  Option Plan. A copy of the Amended Option Plan is attached
as Exhibit A to this Proxy Statement.

The Amended Option Plan

           The Board of Directors adopted,  subject to stockholder approval, the
Amended  Option  Plan for the  purposes  of  securing  for the  Company  and its
stockholders  the benefits  arising from capital  stock  ownership by employees,
officers and directors of, and  consultants  or advisors to, the Company and its
parent  and  subsidiary  corporations  who are  expected  to  contribute  to the
Company's future growth and success.

           Administration.  The Amended Option Plan will be  administered by the
Board of  Directors  of the  Company or a committee  of the Board of  Directors,
whose construction and interpretation of the terms and provisions of the Amended
Option Plan shall be final and conclusive.

           Eligibility.  Options  may be granted to persons who are, at the time
of grant,  employees,  officers or directors of, or  consultants or advisors to,
the Company (each a "Participant").

           Options.  Options  granted  under  the  Amended  Option  Plan  may be
Incentive  Stock  Options  ("ISOs") or  nonqualified  stock  options.  An option
entitles a  Participant  to purchase  shares of Common Stock from the Company at
the option price.  The option price may be paid in cash or with shares of Common
Stock. The purchase price per share of stock deliverable upon the exercise of an
option will be determined  by the Board of Directors,  provided that in the case
of nonqualified stock options, the exercise price cannot be less than 50% of the
fair market value of such stock, as determined by the Board of Directors, at the
time of grant of such option. In the case of ISOs,  however,  the exercise price
cannot be

825592.5
                                      -19-

<PAGE>



less than 100% of the fair market  value of such  stock,  as  determined  by the
Board of Directors,  at the time of grant of the option (110% of the fair market
value  in the  case  of an  ISO  granted  to a ten  percent  stockholder  of the
Company).  Options may be exercised at such time or times and during such period
as may be set forth in the  agreement  evidencing  such  option,  subject to the
provisions of the Amended  Option Plan, but the maximum term of an option is ten
years  from the date of grant,  or five years from the date of grant in the case
of an ISO granted to a ten percent stockholder.

           ISOs may only be granted to  employees;  however,  no employee may be
granted  ISOs (under the Amended  Option Plan or any other plan of the  Company)
that are  first  exercisable  in a  calendar  year for  Common  Stock  having an
aggregate fair market value  (determined  as of the respective  date or dates of
grant) of more than $100,000. In addition, no Participant may be granted options
in any calendar year for more than 600,000 shares of Common Stock.

           Transferability.  Awards  granted  under the Amended  Option Plan are
generally  non-transferable,   except  by  will  or  the  laws  of  descent  and
distribution.

           Share  Authorization.  The maximum  number of shares of Common  Stock
that may be issued  pursuant to options  granted  under the Amended  Option Plan
shall be the greater of (i)  2,500,000  shares  (which  currently is the maximum
amount permitted prior to the amendments  contemplated hereby) and (ii) eighteen
(18%)  percent  of the  total  number  of shares  of  Common  Stock  issued  and
outstanding  (assuming all unexpired and  outstanding  options are exercised and
the Common  Stock  subject to such  options is issued) as of the last day of the
prior  calendar  year.  All awards  made under the  Amended  Option Plan will be
evidenced by written  agreements  between the Company and the  Participant.  The
share limitation and terms of outstanding options will be adjusted, as the Board
of Directors  deems  appropriate,  in the event of a stock  split,  combination,
reclassification,  recapitalization or other similar event. As of April 2, 1999,
approximately  60 individuals were eligible to participate in the Amended Option
Plan.

           Termination  and Amendment.  Unless  terminated  sooner in accordance
with its terms,  the Amended Option Plan will  terminate,  with respect to ISOs,
upon the  earlier of (i) the close of  business  on the day next  preceding  the
tenth anniversary of the original date of adoption of the 1994 Stock Option Plan
by the Board of  Directors,  or (ii) the date on which all shares  available for
issuance  under the Amended  Option Plan shall have been issued  pursuant to the
exercise or  cancellation  of options  granted  under the Amended  Option  Plan.
Unless  terminated  sooner in accordance with its terms, the Amended Option Plan
will  terminate with respect to options which are not ISOs on the date specified
in (ii) above.

Certain Federal Income Tax Consequences.

           In general,  a participant will not recognize taxable income upon the
grant or exercise of an ISO. However, upon the exercise of an ISO, the excess of
the fair market  value of the shares  received on the date of exercise  over the
exercise  price of the shares will be treated as an  adjustment  to  alternative
minimum  taxable  income.  When a  participant  disposes  of shares  acquired by
exercise of an ISO,  the  participant's  gain (the  difference  between the sale
proceeds  and  the  price  paid by the  participant  for the  shares)  upon  the
disposition  will be taxed as capital  gain  provided the  participant  does not
dispose  of the shares  within two years  after the date of grant nor within one
year after the date of exercise,  and  exercises the option while an employee of
the Company or of a  subsidiary  of the  Company or within  three  months  after
termination  of employment  for reasons other than death or  disability.  If the
first  condition is not met, the  participant  generally  will realize  ordinary
income in the year of the disqualifying disposition.  If the second condition is
not met, the participant  generally will recognize ordinary income upon exercise
of the ISO.


825592.5
                                      -20-

<PAGE>



           In general,  a participant  who receives a nonqualified  stock option
will  recognize no income at the time of the grant of the option.  Upon exercise
of a nonqualified  stock option, a participant will recognize ordinary income in
an amount equal to the excess of the fair market value of the shares on the date
of exercise  over the  exercise  price of the option.  Special  timing rules may
apply to a participant who is subject to Section 16(a) of the Exchange Act.

           The employer  (either the Company or its affiliate)  will be entitled
to claim a  federal  income  tax  deduction  on  account  of the  exercise  of a
nonqualified  option.  The amount of the deduction will be equal to the ordinary
income  recognized  by the  participant.  The employer will not be entitled to a
federal  income tax deduction on account of the grant or the exercise of an ISO.
The  employer  may claim a federal  income tax  deduction  on account of certain
disqualifying dispositions of Common Stock acquired upon the exercise of an ISO.

           The  transfer of a vested  non-qualified  stock option to a permitted
family  member will have no  immediate  tax  consequences  to the  Company,  the
participant or such permitted family member. Upon the subsequent exercise of the
transferred  option by the permitted family member, the participant will realize
ordinary  income in an amount  measured  by the  difference  between  the option
exercise  price and the fair market value of the shares on the date of exercise,
and the  employer  will be  entitled  to a  deduction  in the same  amount.  Any
difference  between such fair market value and the price at which the  permitted
family member may subsequently  sell such shares will be treated as capital gain
or loss to the permitted family member, long-term or short-term depending on the
length of time the shares have been held by the permitted family member.

           Section  162(m) of the Code places a limitation  of $1,000,000 on the
amount of compensation  payable to each of the named executive officers that the
Company may deduct for federal income tax purposes.  The limit does not apply to
certain  performance-based  compensation  paid  under  a  plan  that  meets  the
requirements  of the Code and  regulations  promulgated  thereunder.  While  the
Amended   Option   Plan   generally   complies   with   the   requirements   for
performance-based compensation, options granted at less than 100% of fair market
value under the Amended Option Plan will not satisfy those requirements.

Board Recommendation

           The Board of  Directors  believes  the Amended  Option Plan is in the
best interests of the Company and its  stockholders  and therefore  recommends a
vote FOR this proposal.


825592.5
                                      -21-

<PAGE>



        APPROVAL OF AMENDMENT OF CERTIFICATE OF INCORPORATION TO INCREASE
                             AUTHORIZED COMMON STOCK

           The Board of  Directors  has approved  and has  recommended  that the
stockholders  of  the  Company  approve  an  amendment  to  the  Certificate  of
Incorporation  providing  for an increase  from  20,000,000 to 35,000,000 in the
number of authorized  shares of Common Stock. As of May 7, 1999, the Company had
a total of approximately 14,921,071 shares of Common Stock outstanding, warrants
to purchase  2,367,000 shares of Common Stock pursuant to two warrant agreements
with  Sepracor,  options  to  purchase  2,514,000  shares of Common  Stock  were
outstanding  under the Company's stock option plans and 226,000 shares of Common
Stock  reserved for future  issuance  under its stock option and stock  purchase
plans.

           If the amendment is approved,  the  additional  authorized  shares of
Common  Stock  would be  available  for  issuance  in the future  for  corporate
purposes,  including without limitation,  financings  (including the COBE Option
described  below),  acquisitions,   strategic  alliances,  stock  splits,  stock
dividends and management  incentive and employee  benefit plans, as the Board of
Directors  may deem  advisable,  without the  necessity  of further  stockholder
action.  The issuance of  additional  shares of Common  Stock,  while  providing
desirable  flexibility in connection with possible future financings,  strategic
alliances and other  corporate  purposes,  would have the effect of diluting the
Company's  current  stockholders  and  could  have the  effect of making it more
difficult for a third party to acquire,  or of  discouraging  a third party from
attempting to acquire,  control of the Company.  The amendment has been proposed
by  the  Company  for  the  reasons  stated  above  and  not  for  any  possible
anti-takeover effects it may have.

           Pursuant  to a  Stock  Subscription  Agreement,  dated  May 3,  1999,
between the Company  and COBE,  (i) COBE  purchased  from the  Company,  and the
Company  issued  to COBE,  4,500,000  shares  of  Common  Stock at an  aggregate
purchase  price of $9 million and (ii)  subject to  stockholder  approval of the
proposal  described  above,  the  Company  granted  COBE an option to acquire $3
million of Common Stock at a per share price equal to the average  closing price
per share of Common  Stock for the thirty (30)  trading  day period  immediately
prior to the date of exercise of such option.  The COBE Option is exercisable at
any time  after  August  2,  1999 and  prior to May 3,  2000 and is  subject  to
stockholder  approval of the  proposal set forth above in order that the Company
have a sufficient  number of shares  available  for  issuance  upon the exercise
thereof.  Shareholders are not, however, being asked to pass upon or approve the
COBE Option specifically.

Board Recommendation

           The Board of Directors believes that the approval of the amendment in
the Certificate of  Incorporation  increasing the number of shares of authorized
Common Stock is in the best  interests of the Company and its  stockholders  and
therefore recommends a vote FOR this proposal.


825592.5
                                      -22-

<PAGE>



                             INDEPENDENT ACCOUNTANTS

           PricewaterhouseCoopers  LLP is  currently  serving  as the  Company's
independent  accountants.  Coopers & Lybrand L.L.P.  has served as the Company's
independent  accountants since 1998.  Representatives of  PricewaterhouseCoopers
LLP are  expected  to be  present  at the  Annual  Meeting.  They  will have the
opportunity  to  make a  statement  if they  desire  to do so and  will  also be
available to respond to appropriate questions from stockholders.

                                  OTHER MATTERS

           The Board of Directors  does not know of any other  matters which may
come before the meeting. However, if any other matters are properly presented to
the meeting,  it is the intention of the persons named in the accompanying proxy
to vote, or otherwise act, in accordance with their judgment on such matters.

           All costs of solicitation of proxies will be borne by the Company. In
addition to solicitations by mail, the Company's directors, officers and regular
employees,  without additional  remuneration,  may solicit proxies by telephone,
telegraph,   facsimile  and  personal   interviews.   Brokers,   custodians  and
fiduciaries will be requested to forward proxy soliciting material to the owners
of stock held in their  names,  and the Company  will  reimburse  them for their
reasonable  out-of-pocket  expenses incurred in connection with the distribution
of proxy materials.

Deadline For Submission of Stockholder Proposals for the 2000 Annual Meeting

           Proposals of stockholders intended to be presented at the 2000 Annual
Meeting of Stockholders  must be received by the Company at its principal office
in Marlborough,  Massachusetts not later than December 31, 1999 for inclusion in
the proxy statement for that meeting.

                                              By Order of the Board of Directors



                                              JAMES B. MURPHY
                                              Secretary


May 24, 1999



                     THE BOARD OF DIRECTORS ENCOURAGES STOCKHOLDERS TO ATTEND
THE MEETING. WHETHER OR NOT YOU PLAN TO ATTEND, YOU ARE URGED TO COMPLETE, DATE,
SIGN AND  RETURN  THE  ENCLOSED  PROXY IN THE  ACCOMPANYING  ENVELOPE.  A PROMPT
RESPONSE  WILL  GREATLY  FACILITATE   ARRANGEMENTS  FOR  THE  MEETING  AND  YOUR
COOPERATION  WILL BE APPRECIATED.  STOCKHOLDERS WHO ATTEND THIS MEETING MAY VOTE
THEIR STOCK PERSONALLY EVEN THOUGH THEY HAVE SENT IN THEIR PROXIES.

825592.5
                                      -23-

<PAGE>



                                                                       EXHIBIT A



                                 HEMASURE, INC.

                              AMENDED AND RESTATED
                             1994 STOCK OPTION PLAN


1.         Purpose.

           The purpose of this plan (the "Plan") is to secure for HemaSure  Inc.
(the  "Company") and its  shareholders  the benefits  arising from capital stock
ownership by employees,  officers and directors of, and  consultants or advisors
to, the Company and its parent and subsidiary  corporations  who are expected to
contribute to the Company's future growth and success.  Except where the context
otherwise requires,  the term "Company" shall include the parent and all present
and future  subsidiaries  of the Company as defined in Section 424(e) and 424(f)
of the Internal  Revenue Code of 1986,  as amended or replaced from time to time
(the  "Code").  Those  provisions  of the Plan which make  express  reference to
Section 422 shall apply only to Incentive Stock Options (as that term is defined
in the Plan).

2.         Type of Options and Administration.

           (a) Types of Options.  Options granted  pursuant to the Plan shall be
authorized  by action of the Board of  Directors  of the Company (or a Committee
designated by the Board of Directors) and may be either  incentive stock options
("Incentive  Stock Options") meeting the requirements of Section 422 of the Code
or  non-statutory  options  which are not intended to meet the  requirements  of
Section 422 of the Code.

           (b)  Administration.  The Plan will be  administered  by the Board of
Directors of the Company, whose construction and interpretation of the terms and
provisions of the Plan shall be final and conclusive. The Board of Directors may
in its sole discretion  grant options to purchase shares of the Company's Common
Stock  ("Common  Stock")  and issue  shares  upon  exercise  of such  options as
provided  in the Plan.  The Board shall have  authority,  subject to the express
provisions of the Plan, to construe the  respective  option  agreements  and the
Plan, to  prescribe,  amend and rescind  rules and  regulations  relating to the
Plan, to determine the terms and provisions of the respective option agreements,
which  need  not be  identical,  and to make  all  other  determinations  in the
judgment of the Board of Directors necessary or desirable for the administration
of the  Plan.  The Board of  Directors  may  correct  any  defect or supply  any
omission or reconcile any  inconsistency  in the Plan or in any option agreement
in the manner and to the extent it shall deem  expedient  to carry the Plan into
effect and it shall be the sole and final judge of such expediency.  No director
or person acting pursuant to authority delegated by the Board of Directors shall
be liable for any action or determination under the Plan made in good faith. The
Board of  Directors  may, to the full extent  permitted  by or  consistent  with
applicable laws, Section 162(m) of the Code or any regulations thereunder or any
successor section of the Code or regulations  thereunder  ("Section  162(m)") or
regulations (including, without limitation,

825592.5
                                       -1-

<PAGE>



applicable state law and Rule 16b-3  promulgated  under the Securities  Exchange
Act of 1934  (the  "Exchange  Act"),  or any  successor  rule  ("Rule  16b-3")),
delegate  any  or  all  of  its  powers  under  the  Plan  to a  committee  (the
"Committee")  appointed by the Board of  Directors,  and if the  Committee is so
appointed  all  references  to the Board of Directors in the Plan shall mean and
relate to such Committee.

           (c)  Applicability of Rule 16b-3.  Those provisions of the Plan which
make  express  reference  to Rule 16b-3 shall apply only to such  persons as are
required to file reports  under  Section 16(a) of the Exchange Act (a "Reporting
Person").

3.         Eligibility.

           (a)  General.  Options may be granted to persons who are, at the time
of grant,  employees,  officers or directors of, or  consultants or advisors to,
the  Company;  provided,  that the class of employees  to whom  Incentive  Stock
Options  may be granted  shall be limited to all  employees  of the  Company.  A
person who has been granted an option may, if he or she is  otherwise  eligible,
be granted additional  options if the Board of Directors shall so determine.  No
employee shall be granted  options to purchase more than an aggregate of 600,000
shares  of  Common  Stock  under  the Plan in any one  calendar  year.  For this
purpose,  the issuance of new options in substitution  for  outstanding  options
shall be deemed to  constitute a new grant of additional  options  separate from
the original grant of the options that are to be canceled.

           (b) Grant of Options to Directors  and  Officers.  The selection of a
director or officer (as the terms  "directors"  and  "officers"  are defined for
purposes  of Rule  16b-3)  as a  recipient  of an  option  shall be  either  (i)
determined by (A) the Board of Directors or (B) by two or more directors  having
full  authority  to act in the  matter,  each of whom  shall be a  "non-employee
director" within the meaning of Rule 16b-3, (ii) approved in advance or ratified
by the  shareholders of the Company in accordance with Rule 16b-3(d)(3) or (iii)
made in reliance on another available  exemption from the application of Section
16(b). To the extent  compliance with Section 162(m) of the Code is desired,  in
addition to the foregoing if applicable,  the selection of a "covered  employee"
(as defined in Section  162(m) of the Code) as a recipient of an option shall be
made by two or more directors  each of whom is an "outside  director" as defined
in Section 162(m) of the Code.

4.         Stock Subject to Plan.

           Subject to  adjustment  as provided in Section 15 below,  the maximum
number of shares of Common Stock  reserved and available for issuance  under the
Amended Option Plan shall be such  aggregate  number of Common Stock as does not
exceed the greater of (i)  2,500,000  shares of Common  Stock and (ii)  eighteen
(18%)  percent  of the  total  number  of shares  of  Common  Stock  issued  and
outstanding  (assuming all unexpired and  outstanding  options are exercised and
the Common  Stock  subject to such  options is issued) as of the last day of the
prior calendar year. Notwithstanding the foregoing, the maximum number of shares
of Common  Stock for which  Incentive  Stock  Options  may be granted  under the
Amended Option Plan shall not exceed 2,500,000  shares of Common Stock,  reduced
by the aggregate  number of shares of Common Stock  subject to  then-outstanding
Incentive Stock Options. For purposes of this limitation,  if any portion of the
then-outstanding Incentive Stock Options are forfeited,  canceled, reacquired by
the

825592.5
                                       -2-

<PAGE>



Company, satisfied without the issuance of Common Stock or otherwise terminated,
the  shares of Common  Stock  underlying  such  portion of the  Incentive  Stock
Options shall be added back to the shares of Common Stock available for issuance
under the Amended Option Plan.

5.         Forms of Option Agreements.

           As a  condition  to the  grant of an  option  under  the  Plan,  each
recipient  of an  option  shall  execute  an option  agreement  in such form not
inconsistent  with the Plan as may be approved by the Board of  Directors.  Such
option agreements may differ among recipients.

6.         Purchase Price.

           (a) General.  The purchase price per share of stock  deliverable upon
the  exercise  of an  option  shall be  determined  by the  Board of  Directors,
provided,  however,  that  (i) in the case of an  Incentive  Stock  Option,  the
exercise  price  shall not be less than  100% of the fair  market  value of such
stock,  as determined  by the Board of  Directors,  at the time of grant of such
option,  or less  than 110% of such fair  market  value  in the case of  options
described in Section 11(b), and (ii) in the case of a non-qualified  option, the
exercise  price  shall  not be less  than 50% of the fair  market  value of such
stock,  as determined  by the Board of  Directors,  at the time of grant of such
option.

           (b) Payment of Purchase  Price.  Options  granted  under the Plan may
provide for the payment of the exercise  price by delivery of cash or a check to
the  order of the  Company  in an  amount  equal to the  exercise  price of such
options,  or, to the extent provided in the applicable option agreement,  (i) by
delivery to the Company of shares of Common Stock of the Company  already  owned
by the optionee having a fair market value equal in amount to the exercise price
of the options  being  exercised,  (ii) by any other means  (including,  without
limitation,  by delivery of a promissory  note of the  optionee  payable on such
terms as are specified by the Board of  Directors)  which the Board of Directors
determines are consistent  with the purpose of the Plan and with applicable laws
and regulations  (including,  without limitation,  the provisions of Rule 16b-3,
Section  162(m) and  Regulation T promulgated  by the Federal  Reserve Board) or
(iii) by any  combination  of such methods of payment.  The fair market value of
any shares of the Company's Common Stock or other non-cash  consideration  which
may be delivered  upon exercise of an option shall be determined by the Board of
Directors.

7.         Option Period.

           Each option and all rights  thereunder  shall  expire on such date as
shall be set forth in the applicable option agreement,  except that, in the case
of an Incentive Stock Option,  such date shall not be later than ten years after
the date on which the option is granted  and,  in all  cases,  options  shall be
subject to earlier termination as provided in the Plan.

8.         Exercise of Options.

           Each option  granted  under the Plan shall be  exercisable  either in
full or in installments at such time or times and during such period as shall be
set forth in the agreement evidencing such option,  subject to the provisions of
the Plan.

825592.5
                                       -3-

<PAGE>



9.         Nontransferability of Options.

           Incentive  Stock Options shall not be assignable or  transferable  by
the person to whom they are granted,  either voluntarily or by operation of law,
except by will or the laws of descent and distribution,  and, during the life of
the optionee,  shall be exercisable only by the optionee.  Non-statutory options
may be transferred with the consent of the Board of Directors to family members,
trusts  for family  members or  partnerships  in which all of the  partners  are
family members or family trusts of the option holder.

10.        Effect of Termination of Employment or Other Relationship.

           Except as provided in Section  11(d) with respect to Incentive  Stock
Options, and subject to the provisions of the Plan, the Board of Directors shall
determine  the period of time during  which an optionee  may  exercise an option
following (i) the termination of the optionee's employment or other relationship
with the Company or (ii) the death or disability  of the optionee.  Such periods
shall be set forth in the agreement evidencing such option.

11.        Incentive Stock Options.

           Options  granted  under the Plan which are  intended to be  Incentive
Stock Options shall be subject to the following additional terms and conditions:

           (a) Express  Designation.  All Incentive  Stock Options granted under
the Plan shall, at the time of grant, be specifically  designated as such in the
option agreement covering such Incentive Stock Options.

           (b) 10%  Shareholder.  If any  employee  to whom an  Incentive  Stock
Option  is to be  granted  under  the Plan is,  at the time of the grant of such
option, the owner of stock possessing more than 10% of the total combined voting
power of all classes of stock of the  Company  (after  taking  into  account the
attribution of stock  ownership  rules of Section 424(d) of the Code),  then the
following  special  provisions shall be applicable to the Incentive Stock Option
granted to such individual:

                     (i) The  purchase  price  per  share  of the  Common  Stock
           subject to such Incentive Stock Option shall not be less than 110% of
           the fair  market  value of one share of  Common  Stock at the time of
           grant: and

                     (ii) the option exercise period shall not exceed five years
           from the date of grant.

           (c)  Dollar  Limitation.  For so long as the Code  shall so  provide,
options  granted to any employee under the Plan (and any other  incentive  stock
option plans of the Company)  which are intended to constitute  Incentive  Stock
Options  shall not  constitute  Incentive  Stock Options to the extent that such
options,  in the  aggregate,  become  exercisable  for the first time in any one
calendar  year for shares of Common  Stock with an  aggregate  fair market value
(determined as of the respective date or dates of grant) of more than $100,000.


825592.5
                                       -4-

<PAGE>



           (d)  Termination  of Employment,  Death or  Disability.  No Incentive
Stock Option may be exercised unless, at the time of such exercise, the optionee
is,  and has been  continuously  since  the date of grant of his or her  option,
employed by the Company, except that:

                     (i) an Incentive  Stock Option may be exercised  within the
           period of three months  after the date the  optionee  ceases to be an
           employee  of the Company  (or within  such  lesser  period as  may be
           specified  in the  applicable  option  agreement provided,  that  the
           agreement with respect to such option may designate a longer exercise
           period and that the exercise after such  three-month  period shall be
           treated as the exercise of a non-statutory option under the Plan;

                     (ii)  if the  optionee  dies  while  in the  employ  of the
           Company,  or within three months after the optionee ceases to be such
           an  employee,  the  Incentive  Stock  Option may be  exercised by the
           person to whom it is  transferred  by will or the laws of descent and
           distribution  within  the  period of one year after the date of death
           (or within such lesser  period as may be specified in the  applicable
           option agreement); and

                     (iii) if the optionee  becomes disabled (within the meaning
           of Section 22(e)(3) of the Code or any successor  provision  thereto)
           while in the employ of the Company, the Incentive Stock Option may be
           exercised  within the period of one year after the date the  optionee
           ceases to be such an employee  because of such  disability (or within
           such  lesser  period as may be  specified  in the  applicable  option
           agreement).

For all  purposes  of the Plan and any option  granted  hereunder,  "employment"
shall be defined in accordance with the provisions of Section  1.421-7(h) of the
Income Tax  Regulations  (or any  successor  regulations).  Notwithstanding  the
foregoing  provisions,  no Incentive  Stock  Option may be  exercised  after its
expiration date.

           (e) Savings Clause. To the extent any Incentive Stock Option fails to
be treated as an Incentive Stock Option,  it shall be treated as a non-statutory
stock option.

12.        Additional Provisions.

           (a) Additional Option Provisions.  The Board of Directors may, in its
sole discretion,  include  additional  provisions in option agreements  covering
options granted under the Plan,  including  without  limitation  restrictions on
transfer,  repurchase rights,  commitments to pay cash bonuses, to make, arrange
for or guaranty  loans or to transfer  other property to optionees upon exercise
of options,  or such other  provisions  as shall be  determined  by the Board of
Directors;  provided that such additional  provisions  shall not be inconsistent
with any other  term or  condition  of the Plan and such  additional  provisions
shall not cause any  Incentive  Stock Option  granted  under the Plan to fail to
qualify as an Incentive  Stock  Option  within the meaning of Section 422 of the
Code.

           (b) Acceleration,  Extension, Etc. The Board of Directors may, in its
sole discretion, (i) accelerate the date or dates on which all or any particular
option or options  granted  under the Plan may be  exercised  or (ii) extend the
dates during which all, or any  particular,  option or options granted under the
Plan  may be  exercised;  provided,  however,  that no such  extension  shall be
permitted  if it would cause the Plan to fail to comply with  Section 422 of the
Code or with

825592.5
                                       -5-

<PAGE>



Rule  16b-3 or cause any  option  granted  under the Plan to fail to  qualify as
performance-based compensation within the meaning of Section 162(m).

13.        General Restrictions.

           (a) Investment Representations. The Company may require any person to
whom an option is granted,  as a condition of  exercising  such option,  to give
written  assurances  in substance  and form  satisfactory  to the Company to the
effect that such person is acquiring  the Common Stock subject to the option for
his or her own account for  investment  and not with any  present  intention  of
selling or otherwise  distributing  the same,  and to such other  effects as the
Company  deems  necessary  or  appropriate  in order to comply with  federal and
applicable state securities laws, or with covenants or  representations  made by
the Company in connection with any public offering of its Common Stock.

           (b) Compliance With Securities  Laws. Each option shall be subject to
the  requirement  that if, at any time,  counsel to the Company shall  determine
that the listing,  registration or  qualification  of the shares subject to such
option upon any  securities  exchange or under any state or federal  law, or the
consent  or  approval  of any  governmental  or  regulatory  body,  or that  the
disclosure of non-public  information or the satisfaction of any other condition
is necessary as a condition of, or in connection  with, the issuance or purchase
of shares  thereunder,  such option may not be  exercised,  in whole or in part,
unless  such  listing,  registration,  qualification,  consent or  approval,  or
satisfaction  of  such  condition  shall  have  been  effected  or  obtained  on
conditions acceptable to the Board of Directors.  Nothing herein shall be deemed
to require the Company to apply for or to obtain such listing,  registration  or
qualification, or to satisfy such condition.

14.        Rights as a Shareholder.

           The holder of an option  shall have no rights as a  shareholder  with
respect to any shares covered by the option (including,  without limitation, any
rights to receive  dividends  or  non-cash  distributions  with  respect to such
shares ) until the date of issue of a stock  certificate  to him or her for such
shares.  No adjustment shall be made for dividends or other rights for which the
record date is prior to the date such stock certificate is issued.

15.        Adjustment Provisions for Recapitalizations and Related Transactions.

           (a) General. If, through or as a result of any merger, consolidation,
sale of all or substantially  all of the assets of the Company,  reorganization,
recapitalization,  reclassification,  stock dividend, stock split, reverse stock
split or other similar  transaction,  (i) the outstanding shares of Common Stock
are increased,  decreased or exchanged for a different  number or kind of shares
or  other  securities  of the  Company,  or  (ii)  additional  shares  or new or
different shares or other securities of the Company or other non-cash assets are
distributed with respect to such shares of Common Stock or other securities,  an
appropriate and  proportionate  adjustment may be made in (x) the maximum number
and kind of shares reserved for issuance under the Plan, (y) the number and kind
of shares or other securities subject to any then outstanding  options under the
Plan, and (z) the price for each share subject to any then  outstanding  options
under the Plan,  without changing the aggregate  purchase price as to which such
options remain exercisable.  Notwithstanding the foregoing,  no adjustment shall
be made pursuant to this Section 15 if such

825592.5
                                       -6-

<PAGE>



adjustment  would cause the Plan to fail to comply with  Section 422 of the Code
or with Rule 16b-3.

           (b) Board Authority to Make  Adjustments.  Any adjustments under this
Section 15 will be made by the Board of  Directors,  whose  determination  as to
what  adjustments,  if any,  will be made and the extent  thereof will be final,
binding and  conclusive.  No fractional  shares will be issued under the Plan on
account of any such adjustments.

16.        Merger, Consolidation, Asset Sale, Liquidation, etc.

           (a)  General.   Subject  to  Section   16(c),   in  the  event  of  a
consolidation or merger or sale of all or substantially all of the assets of the
Company  in  which  outstanding   shares  of  Common  Stock  are  exchanged  for
securities,  cash or other property of any other  corporation or business entity
or in the event of a liquidation  of the Company,  the Board of Directors of the
Company,  or the board of directors of any corporation  assuming the obligations
of the Company,  may in its  discretion,  take any one or more of the  following
actions,  as to  outstanding  options:  (i) provide that such  options  shall be
assumed,  or  equivalent  options  shall be  substituted,  by the  acquiring  or
succeeding corporation (or an affiliate thereof), provided that any such options
substituted for Incentive  Stock Options shall meet the  requirements of Section
424(a) of the Code, (ii) upon written notice to the optionees,  provide that all
unexercised options will terminate immediately prior to the consummation of such
transaction  unless  exercised by the optionee (to the extent then  exercisable)
within a  specified  period  following  the date of such notice and (iii) in the
event of a merger  under the terms of which  holders of the Common  Stock of the
Company  will receive  upon  consummation  thereof a cash payment for each share
surrendered  in the merger  (the  "Merger  Price"),  make or provide  for a cash
payment to the optionees  equal to the  difference  between (A) the Merger Price
times the number of shares of Common Stock subject to such  outstanding  options
(to the extent then exercisable at prices not in excess of the Merger Price) and
(B) the aggregate exercise price of all such outstanding options in exchange for
the termination of such options.

           (b) Substitute Options.  The Company may grant options under the Plan
in substitution for options held by employees of another  corporation who become
employees of the Company,  or a  subsidiary  of the Company,  as the result of a
merger or  consolidation  of the  employing  corporation  with the  Company or a
subsidiary of the Company,  or as a result of the acquisition by the Company, or
one of its subsidiaries,  of property or stock of the employing corporation. The
Company  may  direct  that  substitute  options  be  granted  on such  terms and
conditions as the Board of Directors considers appropriate in the circumstances.

           (c) Change in Control.  Notwithstanding any other provision contained
herein,  in the event of a "Change in Control" of the Company (as defined below)
each outstanding  option under the Plan held by a person who is then an employee
of the Company shall immediately become exercisable in full. For purposes of the
Plan, a "Change in Control"  shall be deemed to have occurred only if any of the
following  events  occurs:  (i) any  "person,"  as such term is used in Sections
13(d) and 14(d) of the  Exchange  Act (other  than the  Company,  any trustee or
other  fiduciary  holding  securities  under  an  employee  benefit  plan of the
Company,  or any corporation owned directly or indirectly by the stockholders of
the Company in substantially  the same proportion as their ownership of stock of
the  Company),  is or becomes the  "beneficial  owner" (as defined in Rule 13d-3
under the Exchange Act), directly or indirectly, of securities of the

825592.5
                                       -7-

<PAGE>



Company  representing  50% or more of the combined voting power of the Company's
then  outstanding  securities;  (ii) the  stockholders  of the Company approve a
merger or consolidation of the Company with any other corporation,  other than a
merger or  consolidation  which  would  result in the voting  securities  of the
Company outstanding immediately prior thereto continuing to represent (either by
remaining  outstanding  or by being  converted  into  voting  securities  of the
surviving  entity)  more than 50% of the  combined  voting  power of the  voting
securities of the Company or such surviving entity outstanding immediately after
such merger or  consolidation;  (iii) the  stockholders of the Company approve a
plan of  complete  liquidation  of the Company or an  agreement  for the sale or
disposition by the Company of all or substantially  all of the Company's assets;
or (iv)  individuals who, on the date on which the Plan was adopted by the Board
of Directors,  constituted the Board of Directors of the Company,  together with
any new director  whose  election by the Board of Directors  or  nomination  for
election  by the  Company's  stockholders  was  approved by a vote of at least a
majority of the directors then still in office who were directors on the date on
which  the Plan was  adopted  by the Board of  Directors  or whose  election  or
nomination  was  previously  so approved,  cease for any reason to constitute at
least a majority of the Board of Directors.

17.        No Special Employment Rights.

           Nothing  contained in the Plan or in any option shall confer upon any
optionee any right with respect to the  continuation of his or her employment by
the Company or interfere in any way with the right of the Company at any time to
terminate  such  employment or to increase or decrease the  compensation  of the
optionee.

18.        Other Employee Benefits.

           Except  as to plan  which by their  terms  include  such  amounts  as
compensation,  the  amount  of any  compensation  deemed  to be  received  by an
employee as a result of the exercise of an option or the sale of shares received
upon such exercise will not  constitute  compensation  with respect to which any
other  employee  benefits of such employee are  determined,  including,  without
limitation, benefits under any bonus, pension, profit-sharing, life insurance or
salary  continuation  plan, except as otherwise  specifically  determined by the
Board of Directors.

19. Amendment of the Plan.

           (a) The Board of  Directors  may at any time,  and from time to time,
modify or amend the Plan in any respect, except that if at any time the approval
of the  shareholders of the Company is required under Section 422 of the Code or
any successor  provision with respect to Incentive Stock Options, or is required
to ensure  that any  compensation  resulting  from any option  under the Plan is
deductible for federal income tax purposes  under Section  162(m),  the Board of
Directors may not effect such modification or amendment without such approval.

           (b) The  termination  or any  modification  or  amendment of the Plan
shall not, without the consent of an optionee, affect his or her rights under an
option  previously  granted  to him or her.  With the  consent  of the  optionee
affected,  the Board of Directors may amend  outstanding  option agreements in a
manner not  inconsistent  with the Plan.  The Board of Directors  shall have the
right to amend or modify  (i) the terms  and  provisions  of the Plan and of any
outstanding

825592.5
                                       -8-

<PAGE>



Incentive  Stock  Options  granted  under the Plan to the  extent  necessary  to
qualify any or all such options for such favorable  federal income tax treatment
(including  deferral of taxation  upon  exercise)  as may be afforded  incentive
stock options under Section 422 of the Code and (ii) the terms and provisions of
the Plan and of any  outstanding  option to the extent  necessary  to ensure the
qualification of the Plan under Rule 16b-3 or to ensure the deductibility of any
compensation resulting from any option under 162(m).

20.        Withholding.

           (a) The Company  shall have the right to deduct from  payments of any
kind otherwise due to the optionee any federal, state or local taxes of any kind
required by law to be withheld  with respect to any shares  issued upon exercise
of options under the Plan.  Subject to the prior approval of the Company,  which
may be withheld by the Company in its sole discretion, the optionee may elect to
satisfy  such  obligations,  in whole or in part,  (i) by causing the Company to
withhold shares of Common Stock otherwise  issuable  pursuant to the exercise of
an option or (ii) by  delivering  to the Company  shares of Common Stock already
owned by the  optionee.  The shares so delivered  or withheld  shall have a fair
market value equal to such withholding obligation.  The fair market value of the
shares used to satisfy such  withholding  obligation  shall be determined by the
Company  as of  the  date  that  the  amount  of  tax  to be  withheld  is to be
determined.  An optionee who has made an election pursuant to this Section 20(a)
may only satisfy his or her  withholding  obligation with shares of Common Stock
which are not  subject to any  repurchase,  forfeiture,  unfulfilled  vesting or
other similar requirements.

           (b) Notwithstanding the foregoing, in the case of a Reporting Person,
no  election  to use  shares  for the  payment  of  withholding  taxes  shall be
effective  unless made in compliance  with any applicable  requirements  of Rule
16b-3.

21.        Cancellation and New Grant of Options, Etc.

           The Board of Directors  shall have the  authority  to effect,  at any
time and from time to time, with the consent of the affected optionees,  (i) the
cancellation of any or all  outstanding  options under the Plan and the grant in
substitution  therefor  of new  options  under  the  Plan  covering  the same or
different  numbers of shares of Common Stock and having an option exercise price
per share which may be lower or higher than the exercise  price per share of the
canceled  options or (ii) the amendment of the terms of any and all  outstanding
options  under the Plan to provide an option  exercise  price per share which is
higher  or  lower  than  the  then-current  exercise  price  per  share  of such
outstanding options.

22.        Effective Date and Duration of the Plan.

           (a) Effective  Date. The Plan shall become  effective when adopted by
the Board of  Directors,  but no Incentive  Stock Option  granted under the Plan
shall become  exercisable  unless and until the Plan shall have been approved by
the Company's shareholders.  If such shareholder approval is not obtained within
twelve  months  after the date of the  Board's  adoption  of the Plan no options
previously granted under the Plan shall be deemed to be Incentive Stock Options,
options previously granted to covered employees, directors or officers shall not
vest and  shall  terminate  and no  Incentive  Stock  Options  shall be  granted
thereafter nor shall any options be

825592.5
                                       -9-

<PAGE>


granted thereafter to covered employees or officers.  Amendments to the Plan not
requiring  shareholder approval shall become effective when adopted by the Board
of Directors;  amendments requiring shareholder approval (as provided in Section
19) shall  become  effective  when  adopted  by the Board of  Directors,  but no
Incentive  Stock Option  granted after the date of such  amendment and no option
granted to any  covered  employee,  director  or officer  after the date of such
amendment shall become exercisable (to the extent that (i) such amendment to the
Plan was required to enable the Company to grant such Incentive  Stock Option to
a particular optionee or (ii) shareholder approval of such amendment to the Plan
was required to ensure the  continued  qualification  of the Plan under  Section
162(m) or to ensure the  deductibility  of any  compensation  resulting from any
option under  Section  162(m)  unless and until such  amendment  shall have been
approved by the  Company's  shareholders.  If such  shareholder  approval is not
obtained within twelve months of the Board's adoption of such amendment, (i) any
Incentive  Stock Options  granted on or after the date of such  amendment  shall
terminate  to the extent that such  amendment to the Plan was required to enable
the Company to grant such option to a  particular  optionee  and (ii) any option
granted to a covered employee,  director or officer on or after the date of such
amendment  shall  terminate  to the extent  that  shareholder  approval  of such
amendment was required to ensure continued  qualification of the Plan under Rule
16b-3 or  Section  162(m) or to ensure  the  deductibility  of any  compensation
resulting  from any option under  Section  162(m).  Subject to this  limitation,
options may be granted under the Plan at any time after the  effective  date and
before the date fixed for termination of the Plan.

           (b) Termination.  Unless sooner terminated in accordance with Section
16, the Plan shall terminate,  with respect to Incentive Stock Options, upon the
earlier  of (i) the  close of  business  on the day  next  preceding  the  tenth
anniversary  of the date of its adoption by the Board of Directors,  or (ii) the
date on which all shares  available for issuance  under the Plan shall have been
issued  pursuant to the exercise or  cancellation  of options  granted under the
Plan.  Unless sooner  terminated  in accordance  with Section 16, the Plan shall
terminate  with respect to options which are not Incentive  Stock Options on the
date specified in (ii) above. If the date of termination is determined under (i)
above,  then options  outstanding  on such date shall continue to have force and
effect in accordance  with the  provisions of the  instruments  evidencing  such
options.

23.        Provision for Foreign Participants.

           The Board of Directors may, without amending the Plan,  modify awards
or options granted to participants who are foreign nationals or employed outside
the United  States to  recognize  differences  in laws,  rules,  regulations  or
customs of such foreign jurisdictions with respect to tax, securities, currency,
employee benefit or other matters.

                                  Adopted by the Board of Directors on
                                  April 2, 1999

825592.5
                                      -10-

<PAGE>


                                 HEMASURE INC.
                   PROXY SOLICITED BY THE BOARD OF DIRECTORS
                 Annual Meeting of Stockholders - June 10, 1999

     Those signing on the reverse side, revoking any prior proxies, hereby
appoint(s) Timothy J. Barberich and John F. McGuire, or each or any of them,
with full power of substitution, as proxies for those signing on the reverse
side to act and vote at the 1999 Annual Meeting of Stockholders of HemaSure
Inc., and at any adjournments thereof as indicated upon all matters referred to
on the reverse side and described in the Proxy Statement for the Meeting, and,
in their discretion, upon any other matters which may properly come before the
Meeting.

     This proxy when properly executed will be voted in the manner directed by
the undersigned stockholder(s).  If no other indication is made, the proxies
shall vote "For" proposal numbers 1, 2, 3, 4 and 5.

     A vote FOR the director nominees and FOR proposal numbers 2, 3, 4 and 5 is
recommended by the Board of Directors.

PLEASE VOTE, DATE, AND SIGN ON 0THER SIDE AND RETURN PROMPTLY IN ENCLOSED
ENVELOPE.
<PAGE>

                        Please date, sign and mail your
                      proxy card back as soon as possible!

                         Annual Meeting of Stockholders
                                 HEMASURE INC.

                                 June 10, 1999




<TABLE>
<CAPTION>
                Please Detach and Mail in the Envelope Provided
- ------------------------------------------------------------------------------------------------------------------------------------

<S>                      <C>                  <C>                              <C>

/X/ Please mark your
    votes as in this
    example

                               For all          Withhold authority to          Nominees:  Timothy J. Barberich
                          nominees listed     vote for all nominees                       David S. Barlow
                               at right            listed at right                        Rolf S. Stutz
1. ELECTION OF                                                                            John F. McGuire III
   DIRECTORS                     / /                     /  /                             Justin E. Doheny
                                                                                          Edward C. Wood
INSTRUCTIONS:  To withhold authority to vote                                              Frank Corbin
               for individual nominees(s) strike a line through
               each such nominee's name in the list at right.
               Your shares will be voted for the remaining
               nominee(s).


<C>                                                                   <C>
                                                                      FOR         AGAINST       ABSTAIN
2.  Approval of the Amendment to the Company's                        / /          /  /          /  /
    1995 Employee Stock Purchase Plan.

3.  Approval of Amendments to the Company's                           / /          /  /          /  /
    1994 Stock Option Plan.

4.  Approval of the Amendment to the Company's                        / /          /  /          /  /
    Certificate of Incorporation.

5.  To transact such other business as may properly                   / /          /  /          /  /
    come before the meeting or any adjournment
    thereof.


Please read the reverse side of this card.

PLEASE VOTE, SIGN, DATE AND RETURN THE PROXY CARD PROMPTLY USING THE
ENCLOSED ENVELOPE.

HAS YOUR ADDRESS CHANGED?                      DO YOU HAVE ANY COMMENTS?

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     SIGNATURE                                        DATE
              --------------------------------------      ---------------------

     Note:  Please sign this proxy exactly as your name appears hereon. Joint owners should each sign personally. Trustees and other
            fiduciaries should indicate the capacity in which they sign. If a corporation or partnership, this signature should be
            that of an authorized officer who should state his or her title.
</TABLE>



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