LA JOLLA PHARMACEUTICAL CO
S-3/A, 1996-06-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1
 
   
     AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JUNE 13, 1996
    
   
                                                      REGISTRATION NO. 333-04943
    
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
 
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                            ------------------------
 
   
                                AMENDMENT NO. 1
    
   
                                       TO
    
 
                                    FORM S-3
                             REGISTRATION STATEMENT
                                     UNDER
                           THE SECURITIES ACT OF 1933
 
                        LA JOLLA PHARMACEUTICAL COMPANY
             (EXACT NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)
                            ------------------------
 
<TABLE>
<S>                                                <C>
                     DELAWARE                                          33-0361285
          (State or other jurisdiction of                           (I.R.S. Employer
          incorporation or organization)                           Identification No.)
</TABLE>
 
                            ------------------------
 
                             6455 NANCY RIDGE DRIVE
                          SAN DIEGO, CALIFORNIA 92121
                                 (619) 452-6600
              (ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER,
       INCLUDING AREA CODE, OF REGISTRANT'S PRINCIPAL EXECUTIVE OFFICES)
                            ------------------------
 
                                STEVEN B. ENGLE
                            CHIEF EXECUTIVE OFFICER
                        LA JOLLA PHARMACEUTICAL COMPANY
                             6455 NANCY RIDGE DRIVE
                          SAN DIEGO, CALIFORNIA 92121
                                 (619) 452-6600
           (NAME, ADDRESS, INCLUDING ZIP CODE, AND TELEPHONE NUMBER,
                   INCLUDING AREA CODE, OF AGENT FOR SERVICE)
                            ------------------------
 
                                   Copies to:
 
<TABLE>
<S>                                      <C>
        BRIAN W. COPPLE, ESQ.                             ALAN C. MENDELSON, ESQ.
     GIBSON, DUNN & CRUTCHER LLP                           D. BRADLEY PECK, ESQ.
      4 PARK PLAZA, SUITE 1700                    COOLEY GODWARD CASTRO HUDDLESON & TATUM
      IRVINE, CALIFORNIA 92714                       4365 EXECUTIVE DRIVE, SUITE 1100
           (714) 451-3874                            SAN DIEGO, CALIFORNIA 92121-2128
                                                              (619) 550-6000
</TABLE>
 
                            ------------------------
 
     APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO PUBLIC: As soon as
practicable after this registration statement becomes effective.
 
     If the only securities being registered on this form are to be offered
pursuant to dividend or interest reinvestment plans, please check the following
box.  / /
 
     If any of the securities being registered on this Form are to be offered on
a delayed or continuous basis pursuant to Rule 415 under the Securities Act of
1933, other than securities offered only in connection with dividend or interest
reinvestment plans, check the following box.  / /
 
     If this Form is filed to register additional securities for an offering
pursuant to Rule 462(b) under the Securities Act, please check the following box
and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering.  / / _________
 
     If this Form is a post-effective amendment filed pursuant to Rule 462(c)
under the Securities Act, check the following box and list the Securities Act
registration statement number of the earlier effective registration statement
for the same offering.  / / _________
 
   
     If delivery of the prospectus is expected to be made pursuant to Rule 434,
please check the following box.  / /
    
                            ------------------------
 
     THE REGISTRANT HEREBY AMENDS THIS REGISTRATION STATEMENT ON SUCH DATE OR
DATES AS MAY BE NECESSARY TO DELAY ITS EFFECTIVE DATE UNTIL THE REGISTRANT SHALL
FILE A FURTHER AMENDMENT WHICH SPECIFICALLY STATES THAT THIS REGISTRATION
STATEMENT SHALL THEREAFTER BECOME EFFECTIVE IN ACCORDANCE WITH SECTION 8(A) OF
THE SECURITIES ACT OF 1933 OR UNTIL THE REGISTRATION STATEMENT SHALL BECOME
EFFECTIVE ON SUCH DATE AS THE COMMISSION, ACTING PURSUANT TO SAID SECTION 8(A),
MAY DETERMINE.
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
<PAGE>   2
 
   
                                EXPLANATORY NOTE
    
 
   
     This Amendment No. 1 to Registration Statement is filed solely for the
purpose of filing Exhibit 5.1, the opinion of the registrant's counsel as to the
legality of the securities being issued.
    
 
                                    PART II
 
   
                     INFORMATION NOT REQUIRED IN PROSPECTUS
    
 
ITEM 16.  EXHIBITS
 
     Set forth below is a list of the exhibits included as part of this
Registration Statement:
 
   
<TABLE>
<CAPTION>
EXHIBIT
NUMBER               DESCRIPTION
- ------               -----------
<S>      <C>
  1.1    Form of Underwriting Agreement(1)
  5.1    Opinion of Gibson, Dunn & Crutcher
 23.1    Consent of Ernst & Young LLP(1)
 23.2    Consent of Gibson, Dunn & Crutcher (included in Exhibit 5.1)
 24.1    Power of Attorney(1)
</TABLE>
    
 
- ---------------
   
(1) Previously filed with this Registration Statement on May 31, 1996.
    
 
                                      II-1
<PAGE>   3
 
                                   SIGNATURES
 
   
     PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THE REGISTRANT
CERTIFIES THAT IT HAS REASONABLE GROUNDS TO BELIEVE THAT IT MEETS ALL OF THE
REQUIREMENTS FOR FILING ON FORM S-3 AND HAS DULY CAUSED THIS AMENDMENT NO. 1 TO
REGISTRATION STATEMENT TO BE SIGNED ON ITS BEHALF BY THE UNDERSIGNED, THEREUNTO
DULY AUTHORIZED, IN THE CITY OF SAN DIEGO, STATE OF CALIFORNIA, ON JUNE 12,
1996.
    
 
                                          LA JOLLA PHARMACEUTICAL COMPANY
                                          (REGISTRANT)
 
                                          By: /s/       STEVEN B. ENGLE
 
                                            ------------------------------------
                                                      Steven B. Engle
                                                  Chief Executive Officer
 
                               POWER OF ATTORNEY
 
   
     PURSUANT TO THE REQUIREMENTS OF THE SECURITIES ACT OF 1933, THIS AMENDMENT
NO. 1 TO REGISTRATION STATEMENT HAS BEEN SIGNED BY THE FOLLOWING PERSONS IN THE
CAPACITIES AND ON THE DATES INDICATED.
    
 
   
<TABLE>
<CAPTION>
                   NAME                                    TITLE                      DATE
- ------------------------------------------      ---------------------------      --------------
<C>                                             <S>                              <C>
         /s/ STEVEN B. ENGLE                    Director, Chief Executive         June 12, 1996
- ------------------------------------------      Officer and President
             Steven B. Engle                    (Principal Executive
                                                Officer)

          /s/  WOOD C. ERWIN                    Vice President of Finance         June 12, 1996
- ------------------------------------------      and Chief Financial Officer
              Wood C. Erwin                     (Principal Financial
                                                Officer and Principal
                                                Accounting Officer)

                        *                       Director                          June 12, 1996
- ------------------------------------------
             Thomas H. Adams

                        *                       Director                          June 12, 1996
- ------------------------------------------
            William E. Engbers

                        *                       Director                          June 12, 1996
- ------------------------------------------
             Robert A. Fildes

                        *                       Director and Chairman             June 12, 1996
- ------------------------------------------
              Joseph Stemler


         *By: /s/ STEVEN B. ENGLE
- ------------------------------------------
             Steven B. Engle
             Attorney-in-Fact
</TABLE>
    
 
                                      II-2
<PAGE>   4
 
                                 EXHIBIT INDEX
 
   
<TABLE>
<CAPTION>
EXHIBIT
NUMBER                                 DESCRIPTION
- ------   -----------------------------------------------------------------------
<C>      <S>                                                                      <C>
  1.1    Form of Underwriting Agreement(1)
  5.1    Opinion of Gibson, Dunn & Crutcher
 23.1    Consent of Ernst & Young LLP(1)
 23.2    Consent of Gibson, Dunn & Crutcher (included in Exhibit 5.1)
 24.1    Power of Attorney(1)
</TABLE>
    
 
- ---------------
   
(1) Previously filed with this Registration Statement on May 31, 1996.
    

<PAGE>   1
                                                                    EXHIBIT 5.1


                    [GIBSON, DUNN & CRUTCHER LLP LETTERHEAD]

                                 JUNE 12, 1996

            (714) 451-3800                          C 51286-00023

La Jolla Pharmaceutical Company
6455 Nancy Ridge Drive
San Diego, CA 92121

            Re:  Registration Statement on Form S-3
                 (Registration No. 333-04943)

Ladies and Gentlemen:

          We have examined the Registration Statement on Form S-3 (the
"Registration Statement") filed by La Jolla Pharmaceutical Company, a Delaware
corporation (the "Company"), with the Securities and Exchange Commission (the
"Commission") on May 31, 1996 (Registration No. 333-04943), as amended to the
date hereof, in connection with the registration under the Securities Act of
1933, as amended (the "Securities Act"), of up to 3,450,000 shares of the
Company's common stock, par value $.01 per share (the "Shares") to be issued by
the Company in connection with its proposed public offering (the "Offering") as
described in the Registration Statement.

          As your counsel, we have examined the Company's Certificate of
Incorporation and Bylaws, each as amended to the date hereof, and the records of
corporate proceedings and other actions taken by the Company in connection with
the authorization and issuance of the Shares and the sale thereof by the
Company.  Based upon the foregoing and in reliance thereon, and subject to (i)
compliance with applicable state securities laws and (ii) receipt from the
Commission of an order declaring the Registration Statement effective, it is
our opinion that the Shares, when issued and paid for pursuant to the
Registration Statement (and pertinent exhibits thereto) will be validly issued,
fully paid and nonassessable.
<PAGE>   2
GIBSON, DUNN & CRUTCHER LLP

La Jolla Pharmaceutical Company
June 12, 1996
Page 2

         We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement, and we further consent to the use of our name under the
caption "Legal Matters" in the Prospectus forming a part of said Registration
Statement.  In giving this consent, we do not thereby admit that we are within
the category of persons whose consent is required under Section 7 of the
Securities Act or the Rules and Regulations of the Commission.

                                         Very truly yours,


                                         GIBSON, DUNN & CRUTCHER LLP



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