LA JOLLA PHARMACEUTICAL CO
SC 13D/A, 2000-08-02
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D
                                 Amendment No. 3

                    Under the Securities Exchange Act of 1934

                        La Jolla Pharmaceutical Company
                        -------------------------------
                                (Name of Issuer)

                                  Common Stock
                         ------------------------------
                         (Title of Class of Securities)

                                   503459109
                                 --------------
                                 (CUSIP Number)

                                 Eileen McCarthy
                       One Post Office Square, Suite 3800
                                Boston, MA 02109
                                 (617) 482-8020
           -----------------------------------------------------------
           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)

                                  July 19, 2000
             -------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

         If the filing person has  previously  filed a statement on Schedule 13G
to report the  acquisition  which is the subject of this  Schedule  13D,  and is
filing this schedule because of Rule 13d-1(b)(3) or (4), check the following box
|_|.

         Check the following box if a fee is being paid with this statement |_|.
(A fee  is not  required  only  if the  reporting  person:  (1)  has a  previous
statement on file  reporting  beneficial  ownership of more than five percent of
the class of  securities  described  in Item 1; and (2) has  filed no  amendment
subsequent  thereto  reporting  beneficial  ownership of five percent or less of
such class. (See Rule 13d-7).

         Note: Six copies of this statement,  including all exhibits,  should be
filed with the  Commission.  See Rule  13d-1(a) for other parties to whom copies
are to be sent.

         * The  remainder of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

         The information  required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934,  as  amended  (the  "Exchange  Act") or  otherwise  subject  to the
liabilities  of that  section  of the  Exchange  Act but shall be subject to all
other provisions of the Exchange Act.

                        (Continued on following page(s))

                               Page 1 of 18 Pages


<PAGE>


CUSIP No. 503459109                  13D                     Page 2 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Alta Partners
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    WC
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    California
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         1,920,000
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       -0-


                                       (9) Sole Dispositive Power     1,920,000


                                       (10) Shared Dispositive Power  -0-

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,920,000
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               6.6%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               IA
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


<PAGE>





CUSIP No. 503459109                   13D                    Page 3 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Alta BioPharma Partners, L.P.
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    WC
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    Delaware
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         1,193,445
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       -0-


                                       (9) Sole Dispositive Power     1,193,445


                                       (10) Shared Dispositive Power  -0-

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,193,445
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               4.1%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               PN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


<PAGE>


CUSIP No. 503459109                  13D                      Page 4 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Alta Embarcadero BioPharma, LLC
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    WC
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    California
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         44,984
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       -0-


                                       (9) Sole Dispositive Power     44,984


                                       (10) Shared Dispositive Power  -0-

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               44,984
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               0.2%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


<PAGE>



CUSIP No. 503459109                  13D                      Page 5 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    La Jolla Chase Partners (Alta Bio), LLC
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    WC
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    Delaware
--------------------------------------------------------------------------------
Number Of Shares                       (7) Sole Voting Power          681,571
Beneficially Owned
By Each Reporting
Person With                            (8) Shared Voting Power        -0-


                                       (9) Sole Dispositive Power     681,571


                                       (10) Shared Dispositive Power  -0-

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               681,571
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               2.3%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



CUSIP No. 503459109                  13D                      Page 6 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Alta BioPharma Management, LLC
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    WC
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    Delaware
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         1,193,445
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       -0-


                                       (9) Sole Dispositive Power     1,193,445


                                       (10) Shared Dispositive Power  -0-

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,193,445
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               4.1%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



CUSIP No. 503459109                  13D                      Page 7 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Alta/Chase BioPharma Management, LLC
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    WC
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    Delaware
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         681,571
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       -0-


                                       (9) Sole Dispositive Power     681,571


                                       (10) Shared Dispositive Power  -0-

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               681,571
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               2.3%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



CUSIP No. 503459109                  13D                      Page 8 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Jean Deleage
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    AF
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    U.S.A.
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         -0-
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       1,920,000


                                       (9) Sole Dispositive Power     -0-


                                       (10) Shared Dispositive Power  1,920,000

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,920,000
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               6.6%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



CUSIP No. 503459109                  13D                      Page 9 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Garrett Gruener
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    AF
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    U.S.A.
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         -0-
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       1,920,000


                                       (9) Sole Dispositive Power     -0-


                                       (10) Shared Dispositive Power  1,920,000

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,920,000
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               6.6%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



CUSIP No. 503459109                  13D                     Page 10 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Daniel Janney
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    AF
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    U.S.A.
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         -0-
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       1,920,000


                                       (9) Sole Dispositive Power     -0-


                                       (10) Shared Dispositive Power  1,920,000

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,920,000
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               6.6%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



CUSIP No. 503459109                  13D                     Page 11 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Alix Marduel
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    AF
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    U.S.A.
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         -0-
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       1,920,000


                                       (9) Sole Dispositive Power     -0-


                                       (10) Shared Dispositive Power  1,920,000

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,920,000
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               6.6%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>



CUSIP No. 503459109                  13D                     Page 12 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Guy Nohra
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    AF
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    U.S.A.
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         -0-
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       1,920,000


                                       (9) Sole Dispositive Power     -0-


                                       (10) Shared Dispositive Power  1,920,000

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,920,000
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               6.6%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!



<PAGE>


CUSIP No. 503459109                  13D                     Page 13 of 18 Pages

--------------------------------------------------------------------------------
(1) Names of  Reporting  Persons.  SS or  I.R.S.  Identification  Nos.  of Above
    Persons

    Marino Polestra
--------------------------------------------------------------------------------

(2) Check The Appropriate Box If A Member Of A Group    (a) |_|
                                                        (b) |X|
--------------------------------------------------------------------------------
(3) SEC Use Only

--------------------------------------------------------------------------------
(4) Source Of Funds*

    AF
--------------------------------------------------------------------------------
(5) Check Box If Disclosure Of Legal  Proceedings Is Required  Pursuant To Items
    2(d) Or 2(e) |_|

--------------------------------------------------------------------------------
(6) Citizenship Or Place Of Organization

    U.S.A.
--------------------------------------------------------------------------------
Number Of Shares                       (7)  Sole Voting Power         -0-
Beneficially Owned
By Each Reporting
Person With                            (8)  Shared Voting Power       1,920,000


                                       (9) Sole Dispositive Power     -0-


                                       (10) Shared Dispositive Power  1,920,000

(11) Aggregate Amount Beneficially Owned By Each Reporting Person

               1,920,000
--------------------------------------------------------------------------------
(12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares*


--------------------------------------------------------------------------------
(13) Percent Of Class Represented By Amount In Row (11)

               6.6%
--------------------------------------------------------------------------------
(14) Type Of Reporting Person

               IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!


<PAGE>


Item 1.           Security and Issuer.

                  This  Statement  on  Schedule D relates  to the Common  Stock,
$0.01 par value per share (the "Shares"),  of La Jolla Pharmaceutical Company, a
Delaware  corporation (the "Company").  The principal  executive  offices of the
Company are located at 6455 Nancy Ridge Drive, San Diego, California, 92121.


Item 2.           Identity and Background.

                  (a) This Statement is filed by Alta BioPharma Partners,  L.P.,
a  Delaware  limited  partnership  ("Alta  BioPharma"),   and  Alta  Embarcadero
BioPharma,  LLC, a California limited liability company ("Embarcadero LLC"), and
La Jolla Chase Partners (Alta Bio), LLC, a Delaware LLC ("La Jolla Alta Bio") by
virtue  of their  direct  beneficial  ownership  of  Shares,  by Alta  BioPharma
Management   Partners,   LLC,  a  Delaware  limited   liability  company  ("Alta
Management"),  by virtue of being the sole general partner of Alta BioPharma, by
Alta/Chase  BioPharma  Management  LLC, a  Delaware  limited  liability  company
(Alta/Chase  Management)  by virtue of being the sole  managing  director  of La
Jolla  Chase  Partners  (Alta  Bio),  LLC and by  Alta  Partners,  a  California
corporation  ("Alta  Partners"),  by  virtue of being  the  management  advisory
company of these entities. Alta BioPharma, Embarcadero LLC, La Jolla Chase (Alta
Bio), Alta Management,  Alta/Chase Management and Alta Partners are collectively
referred to as the  "Reporting  Persons."  Jean Deleage,  Garrett  Gruener,  Dan
Janney,  Alix Marduel,  Guy Nohra and Marino  Polestra (the  "Partners") are the
managing  directors of Alta  Management,  Alta/Chase  Management and officers of
Alta Partners.  By virtue of the  relationships  described above and their roles
with Alta Partners, each of the Partners may be deemed to control Alta Partners,
Alta/Chase Management, Alta Management, and, therefore, may be deemed to possess
indirect beneficial ownership of the Shares held by each entity.  However,  none
of the Partners,  acting alone,  has voting or investment  power with respect to
the Shares  directly  beneficially  held by the entities  and, as a result,  the
Partners disclaim beneficial ownership of the Shares directly beneficially owned
by each entity, except to the extent of their pecuniary interest in each entity.
Embarcadero  LLC is a side  company that makes all  investments  pro rata to the
capital of Alta  BioPharma  with all  allocations  made to its members  based on
paid-in  capital.  Certain of the  Partners are members of  Embarcadero  LLC and
certain members of Embarcadero LLC are affiliates of Alta Partners.

                  (b)  The  principal   executive  offices  of  Alta  BioPharma,
Embarcadero LLC, La Jolla Alta Bio, Alta Management,  Alta/Chase  Management and
Alta  Partners,  and the business  address of each  Partner,  are located at One
Embarcadero Center, Suite 4050, San Francisco, California 94111.

                  (c) Alta Partners  provides  investment  advisory  services to
venture capital firms.  Alta BioPharma,  La Jolla Alta Bio and Embarcadero LLC's
principal business is acting as venture capital investment vehicles.  Alta/Chase
Management  and Alta  Management's  principal  business  is acting  as  managing
director  of La Jolla  Alta Bio and Alta  BioPharma,  respectively.  Each of the
Partners' principal business is acting as a managing director of Alta Management
and Alta/Chase Management and as an officer of Alta Partners.

                  (d) None of the Reporting  Persons or, to the knowledge of the
Reporting  Persons,  any of the  Partners,  has  been  convicted  in a  criminal
proceeding  in the past five  years  (excluding  traffic  violations  or similar
misdemeanors).

                  (e) During the past five years,  none of the Reporting Persons
or, to the knowledge of the Reporting Persons,  and none of the Partners,  was a
party to a civil  proceeding of a judicial or  administrative  body of competent
jurisdiction  as a result of which such  person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, federal or state securities laws of finding any
violation with respect to such laws.


<PAGE>


                  (f) Alta Partners is a California corporation.  Alta BioPharma
is a Delaware  limited  partnership.  Embarcadero  LLC is a  California  limited
liability  corporation.  La Jolla Chase Alta Bio is a Delaware limited liability
company.   Alta  Management  and  Alta/Chase  Management  are  Delaware  limited
liability companies. Each of the Partners is a citizen of the United States.

Item 3.           Source and Amount of Funds or Other Consideration.

                  The  total  amount  of funds  required  by Alta  BioPharma  to
acquire  the  1,193,445  shares  of  Common  Stock  reported  in Item  5(a)  was
$6,819,043.98,  the total amount of funds required by Embarcadero LLC to acquire
the 44,984 shares of Common Stock reported in Item 5(a) was  $257,027.24 and the
total  amount of funds  required  by La Jolla  Alta Bio to acquire  the  681,571
shares of Common Stock reported in Item 5(a) was $3,894,324.94.  Such funds were
provided by each entity's capital available for investment.

Item 4.           Purpose of Transaction.

                  Alta  BioPharma,  Embarcadero  LLC,  and  La  Jolla  Alta  Bio
acquired the Common Stock reported in Item 5(c) for investment  only.  Depending
upon their  evaluation  of the Company's  investments  and  prospects,  and upon
future developments  (including,  but not limited to, market for the Shares, the
effective yield on the Shares, availability of funds, alternative uses of funds,
and money, stock market and general economic conditions),  each of the Reporting
Persons may from time to time  purchase  the Common  Stock,  dispose of all or a
portion of the Common  Stock that it holds,  or cease  buying or selling  Common
Stock. Any such additional purchases or sales of the Common Stock may be in open
market or privately negotiated transactions or otherwise.

                  On February 17, 2000, Alta  BioPharma,  Embarcadero LLC and La
Jolla Alta Bio entered  into a Stock  Purchase  Agreement  (the "Stock  Purchase
Agreement") with the Company  pursuant to which Alta BioPharma,  Embarcadero LLC
and La Jolla  Chase  Alta  Bio  acquired,  for an  aggregate  purchase  price of
$7,375,989.06,  a total of 1,470,000  Shares of Common Stock.  The entities also
entered into a Registration Rights Agreement.  On July 19, 2000, Alta BioPharma,
Embarcadero LLC and La Jolla Alta Bio acquired,  for an aggregate purchase price
of  $2,756,250.01,  a total of 450,000 Shares of Common Stock. The entities also
entered into a Registration Rights Agreement.

Item 5.           Interest in Securities of the Issuer.

                  (a) Alta BioPharma is the direct beneficial owner of 1,193,445
shares of Common Stock or approximately 4.1% of the shares deemed outstanding by
the Company  (29,286,234)  as of July 19, 2000.  La Jolla Alta Bio is the direct
beneficial owner of 681,571 shares of Common Stock or approximately  2.3% of the
shares  deemed  outstanding  by the Company  (29,286,234)  as of July 19,  2000.
Embarcadero LLC is the direct  beneficial owner of 44,984 shares of Common Stock
or  approximately   0.2%  of  the  shares  deemed  outstanding  by  the  Company
(29,286,234) as of July 19, 2000.

                  (b) Each entity has the power to direct the disposition of and
vote the stock held by it. By virtue of the  relationships  previously  reported
under Item 2 of this Statement, Alta Management,  Alta/Chase Management and Alta
Partners may be deemed to have indirect beneficial ownership of the shares owned
by such entities.

                  (c) On February  17, 2000 Alta  BioPharma,  La Jolla Alta Bio,
and Embarcadero LLC acquired the Shares described in Item 3 of this Statement in
a privately negotiated transaction with the Company for aggregate  consideration
of $3,083,842.13, $1,761,169.50 and $116,238.38, respectively.
<PAGE>


                  On July 19,  20000  Alta  BioPharma,  La Jolla  Alta Bio,  and
Embarcadero  LLC  acquired an  additional  279,714,  159,743 and 10,543  Shares,
respectively, in a privately negotiated transaction with certain shareholders of
the  Company for  aggregate  consideration  of  $1,713,248.25,  $978,425.88  and
$64,575.88, respectively.

                  Except as set forth above,  neither the Reporting  Persons nor
the Partners  have  effected any  transaction  in the Shares  during the past 60
days.

                  (d) Alta BioPharma, La Jolla Alta Bio and Embarcadero LLC each
have the right to receive  dividends  and proceeds from the sale of Common Stock
held by it. By virtue of the relationships reported in Item 2 of this Statement,
Alta Management,  Alta/Chase  Management and Alta Partners may be deemed to have
the power to direct the receipt of dividends  and the proceeds  from the sale of
the Common Stock held by each entity.


Item 6.           Contracts, Arrangements, Understandings or Relationships with
                  Respect to Securities of the Issuer.

                  The La Jolla  Pharmaceutical  Company Stock Purchase Agreement
dated July 19, 2000 and The La Jolla Pharmaceutical  Company Registration Rights
Agreement dated July 19, 2000 are hereby  incorporated in their entirety by this
reference.

Item 7.           Material to be Filed as Exhibits.

                  Exhibit A:  Joint Filing Statement.

                  Exhibit  B: La Jolla  Pharmaceutical  Company  Stock  Purchase
                  Agreement  dated July 19, 2000.

                  Exhibit C: La Jolla Pharmaceutical Company Registration Rights
                  Agreement  dated July 19, 2000.

<PAGE>


Signature


                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.


Date:  July 19, 2000

Alta Partners                                     Alta BioPharma Partners, L.P.


By:        /s/ /Jean Deleage               By:    Alta BioPharma Management, LLC
      ------------------------------              Its General Partner
      Jean Deleage, Vice President
                                           By:       /s/ Alix Marduel
                                                 -------------------------------
Alta BioPharma Management, LLC                   Alix Marduel, Managing Director


By:        /s/ Garrett Gruener           La Jolla Chase Partners (Alta Bio), LLC
      ------------------------------
      Garrett Gruener, Member
                                           By:    Alta/Chase BioPharma
                                                  Management, LLC
Alta/Chase BioPharma Management, LLC              Its Managing Member

                                           By:       /s/ Alix Marduel
By:        /s/ Alix Marduel                      -------------------------------
      ------------------------------             Alix Marduel, Member
      Alix Marduel, Member

Alta Embarcadero BioPharma, LLC


By:        /s/ Garrett Gruener
      ------------------------------
      Garrett Gruener, Member


            /s/ Jean Deleage                            /s/ Guy Nohra
------------------------------------             -------------------------------
Jean Deleage                                     Guy Nohra

         /s/ /Garrett Gruener                        /s/ Marino Polestra
------------------------------------             -------------------------------
Garrett Gruener                                  Marino Polestra

         /s/ Daniel Janney                           /s/ Alix Marduel
------------------------------------             -------------------------------
Daniel Janney                                    Alix Marduel


<PAGE>



                                    EXHIBIT A

                             Joint Filing Statement

         We, the  undersigned,  hereby  express our agreement  that the attached
Schedule 13D is filed on behalf of each of us.


Date:  July 19, 2000

Alta Partners                                     Alta BioPharma Partners, L.P.


By:        /s/ /Jean Deleage               By:    Alta BioPharma Management, LLC
      ------------------------------              Its General Partner
      Jean Deleage, Vice President
                                           By:       /s/ Alix Marduel
                                                 -------------------------------
Alta BioPharma Management, LLC                   Alix Marduel, Managing Director


By:        /s/ Garrett Gruener           La Jolla Chase Partners (Alta Bio), LLC
      ------------------------------
      Garrett Gruener, Member
                                           By:    Alta/Chase BioPharma
                                                  Management, LLC
Alta/Chase BioPharma Management, LLC              Its Managing Member

                                           By:       /s/ Alix Marduel
By:        /s/ Alix Marduel                      -------------------------------
      ------------------------------             Alix Marduel, Member
      Alix Marduel, Member

Alta Embarcadero BioPharma, LLC


By:        /s/ Garrett Gruener
      ------------------------------
      Garrett Gruener, Member


            /s/ Jean Deleage                            /s/ Guy Nohra
------------------------------------             -------------------------------
Jean Deleage                                     Guy Nohra

         /s/ /Garrett Gruener                        /s/ Marino Polestra
------------------------------------             -------------------------------
Garrett Gruener                                  Marino Polestra

         /s/ Daniel Janney                           /s/ Alix Marduel
------------------------------------             -------------------------------
Daniel Janney                                    Alix Marduel


<PAGE>


                                    Exhibit B


                            STOCK PURCHASE AGREEMENT

         This STOCK PURCHASE  AGREEMENT  (this  "Agreement")  is dated as of the
____  day of  July,  2000 by and  between  La Jolla  Pharmaceutical  Company,  a
Delaware  corporation  with its principal  office at 6455 Nancy Ridge Drive, San
Diego, California (the "Company"), and the several purchasers named in Exhibit A
attached hereto (each, a "Purchaser" and collectively, the "Purchasers").

         WHEREAS,  the Company  desires to issue and sell to the  Purchasers  an
aggregate  of up to  _________  shares  (the  "Shares")  of the  authorized  but
unissued  shares of common stock,  $.01 par value per share, of the Company (the
"Common Stock"); and

         WHEREAS, the Purchasers,  severally, wish to purchase the Shares on the
terms and subject to the conditions set forth in this Agreement.

         NOW   THEREFORE,   in   consideration   of   the   mutual   agreements,
representations,  warranties and covenants herein contained,  the parties hereto
agree as follows:

         1.  Definitions.  As used in this Agreement,  the following terms shall
have the following respective meanings:

                  (a)  "Affiliate"  of a party  means any  corporation  or other
business  entity  controlled  by,  controlling or under common control with such
party.  For this  purpose  "control"  shall mean direct or  indirect  beneficial
ownership  of fifty  percent  (50%) or more of the voting or income  interest in
such corporation or other business entity.

                  (b) "Closing Date" means the date of the Closing.

                  (c) "Exchange Act" means the Securities  Exchange Act of 1934,
as amended, and all of the rules and regulations promulgated thereunder.

                  (d)  "Registration  Rights  Agreement" shall mean that certain
Registration  Rights Agreement,  dated as of the date hereof,  among the Company
and the Purchasers.

                  (e) "Majority  Purchasers" shall mean Purchasers which, at any
given time,  hold  greater than fifty  percent  (50%) of the voting power of the
outstanding Shares.

                  (f) "SEC" shall mean the Securities and Exchange Commission.

                  (g) "Securities Act" shall mean the Securities Act of 1933, as
amended, and all of the rules and regulations promulgated thereunder.

         2. Purchase and Sale of Shares.

                  2.1  Purchase  and  Sale.  Subject  to and upon the  terms and
conditions set forth in this Agreement,  the Company agrees to issue and sell to
each Purchaser,  and each Purchaser,  severally,  hereby agrees to purchase from
the  Company,  at the  Closing,  the number of shares of Common  Stock set forth
opposite the name of such  Purchaser  under the heading  "Number of Shares to be
Purchased"  on Exhibit A hereto,  at a purchase  price of $_____ per share.  The
total  purchase  price  payable  by each  Purchaser  for the number of shares of
Common  Stock that such  Purchaser  is hereby  agreeing to purchase

<PAGE>

is set forth  opposite the name of such  Purchaser  under the heading  "Purchase
Price"  on  Exhibit  A hereto.  The  aggregate  purchase  price  payable  by the
Purchasers to the Company for all of the Shares shall be $___________________.

                  2.2  Closing.  The  closing of the  transactions  contemplated
under this Agreement (the "Closing")  shall take place at the offices of Gibson,
Dunn & Crutcher LLP in Irvine,  California on the second  business day after the
Company shall have given written notice to (the "Closing Notice") the Purchasers
that all of the  conditions  precedent  set  forth  in  Section  6.1  have  been
satisfied in full or at such other location, date and time as may be agreed upon
between the  Purchasers  and the  Company.  At the  Closing,  the Company  shall
deliver to each Purchaser a single stock certificate,  registered in the name of
such Purchaser,  representing  the number of shares of Common Stock purchased by
such Purchaser,  against payment of the purchase price therefor by wire transfer
of immediately  available funds to such account or accounts as the Company shall
designate in writing.

         3.  Representations  and Warranties of the Company.  The Company hereby
represents and warrants to each of the Purchasers as follows:

                  3.1   Incorporation.   The  Company  is  a  corporation   duly
organized,  validly existing and in good standing under the laws of the State of
Delaware  and is  qualified  to do  business in each  jurisdiction  in which the
character  of  its  properties  or the  nature  of its  business  requires  such
qualification,  except where the failure to so qualify would not have a material
adverse effect upon the Company.  The Company has all requisite  corporate power
and authority to carry on its business as now conducted.

                  3.2  Capitalization.  The  authorized  capital  stock  of  the
Company consists of (i) 100,000,000  shares of Common Stock, of which 24,486,234
shares  are  outstanding  as of June  30,  2000  and (ii)  8,000,000  shares  of
preferred  stock, of which no shares are outstanding on the date hereof.  Except
as set forth in Schedule 3.2 hereto,  there are no existing  options,  warrants,
calls,   preemptive  (or  similar)   rights,   subscriptions  or  other  rights,
agreements,  arrangements or commitments of any character obligating the Company
to issue,  transfer or sell,  or cause to be issued,  transferred  or sold,  any
shares of the capital  stock of the  Company or other  equity  interests  in the
Company or any securities  convertible  into or exchangeable  for such shares of
capital  stock  or  other  equity  interests,   and  there  are  no  outstanding
contractual  obligations  of the  Company  to  repurchase,  redeem or  otherwise
acquire any shares of its capital stock or other equity interests.

                  3.3  Authorization.  All  corporate  action on the part of the
Company,   its   officers,   directors  and   stockholders   necessary  for  the
authorization,  execution,  delivery and  performance  of this Agreement and the
Registration   Rights   Agreement  and  the  consummation  of  the  transactions
contemplated  herein and therein has been taken.  When executed and delivered by
the Company,  each of this Agreement and the Registration Rights Agreement shall
constitute the legal, valid and binding  obligation of the Company,  enforceable
against the Company in accordance with its terms,  except as such may be limited
by bankruptcy,  insolvency,  reorganization  or other laws affecting  creditors'
rights  generally  and by general  equitable  principles.  The  Company  has all
requisite  corporate  power to enter into this  Agreement  and the  Registration
Rights Agreement and to carry out and perform its obligations under the terms of
this Agreement, and the Registration Rights Agreement.

                  3.4 Valid Issuance of the Shares.  The Shares being  purchased
by the Purchasers hereunder will, upon issuance pursuant to the terms hereof, be
duly authorized and validly issued, fully paid and nonassessable.

                  3.5  Financial  Statements.  The Company has furnished to each
Purchaser its audited Statements of Income,  Stockholders' Equity and Cash Flows
for the fiscal year ended  December 31, 1999,  its audited  Balance  Sheet as of
December 31, 1999, its unaudited Statements of Income,  Stockholders' Equity and
Cash Flows for the period from  December 31, 1999 through March 31, 2000 and its
unaudited Balance Sheet as of March 31, 2000. All such financial  statements are
hereinafter  referred  to  collectively

                                       2
<PAGE>


as the "Financial  Statements".  The Financial  Statements have been prepared in
accordance with generally accepted accounting principles applied on a consistent
basis during the periods involved, and fairly present, in all material respects,
the  financial  position of the Company and the results of its  operations as of
the  date and for the  periods  indicated  thereon,  except  that the  unaudited
financial statements may not be in accordance with generally accepted accounting
principles  because of the absence of footnotes  normally  contained therein and
are subject to normal year-end audit adjustments which, individually, and in the
aggregate,  will  not be  material.  Since  March  31,  2000,  to the  Company's
knowledge,  there has been no material  adverse change (actual or threatened) in
the assets, liabilities (contingent or other), affairs, operations, prospects or
condition (financial or other) of the Company.

                  3.6  SEC   Documents.   The  Company  has  furnished  to  each
Purchaser,  a true and complete copy of the Company's Annual Report on Form 10-K
for the year ended  December 31, 1999,  the Company's  Quarterly  Report on Form
10-Q for three  months ended March 31, 2000,  and any other  statement,  report,
registration  statement  (other  than  registration  statements  on Form S-8) or
definitive  proxy  statement filed by the Company with the SEC during the period
commencing  December 31, 1999 and ending on the date hereof.  The Company  will,
promptly upon the filing thereof, also furnish to each Purchaser all statements,
reports  (including,  without  limitation,  Quarterly  Reports  on Form 10-Q and
Current  Reports on Form 8-K),  registration  statements  and  definitive  proxy
statements filed by the Company with the SEC during the period commencing on the
date hereof and ending on the Closing  Date (all such  materials  required to be
furnished to each  Purchaser  pursuant to this  sentence or pursuant to the next
preceding  sentence of this  Section 3.6 being  called,  collectively,  the "SEC
Documents").  Except as set forth on Schedule 3.6, as of their respective filing
dates, the SEC Documents  complied or will comply in all material  respects with
the  requirements of the Exchange Act or the Securities Act, as applicable,  and
none of the SEC  Documents  contained or will contain any untrue  statement of a
material  fact or omitted or will omit to state a material  fact  required to be
stated  therein or necessary in order to make the  statements  made therein,  in
light of the  circumstances  under which they were made, not  misleading,  as of
their respective filing dates,  except to the extent corrected by a subsequently
filed SEC Document.

                  3.7   Consents.   All   consents,    approvals,   orders   and
authorizations  required  on the  part of the  Company  in  connection  with the
execution, delivery or performance of this Agreement and the Registration Rights
Agreement  and the  consummation  of the  transactions  contemplated  herein and
therein have been obtained and will be effective as of the Closing Date.

                  3.8 No Conflict.  The execution and delivery of this Agreement
and the Registration Rights Agreement by the Company and the consummation of the
transactions contemplated hereby and thereby will not conflict with or result in
any violation of or default  (with or without  notice or lapse of time, or both)
under, or give rise to a right of  termination,  cancellation or acceleration of
any obligation or to a loss of a material benefit under (i) any provision of the
Certificate of  Incorporation  or bylaws of the Company or (ii) any agreement or
instrument,   permit,  franchise,   license,   judgment,  order,  statute,  law,
ordinance,  rule or  regulations,  applicable  to the Company or its  respective
properties or assets.

                  3.9 Brokers or Finders.  Except for Pacific  Growth  Equities,
Inc., the Company has not dealt with any broker or finder in connection with the
transactions  contemplated by this  Agreement,  and, except for certain fees and
expenses  payable by the Company to Pacific Growth  Equities,  Inc., the Company
has not incurred, and shall not incur, directly or indirectly, any liability for
any brokerage or finders' fees or agents  commissions or any similar  charges in
connection with this Agreement or any transaction contemplated hereby.

                  3.10 Nasdaq National Market. The Common Stock is listed on the
Nasdaq National Market System, and there are no proceedings to revoke or suspend
such listing.

                  3.11  Absence  of  Litigation.  There  is no  action,  suit or
proceeding or, to the Company's knowledge, any investigation, pending, or to the
Company's  knowledge,  threatened by or

                                       3
<PAGE>


before any  governmental  body  against the Company and in which an  unfavorable
outcome,  ruling or finding in any said  matter,  or for all matters  taken as a
whole,  might have a  material  adverse  effect on the  Company.  The  foregoing
includes, without limitation, any such action, suit, proceeding or investigation
that questions this Agreement or the Registration  Rights Agreement or the right
of the Company to execute, deliver and perform under same.

                  3.12 No Bad Acts. The Company represents and warrants that, to
the best of its knowledge,  none of its directors or officers is or has been the
subject of, or a defendant  in: (i) an  enforcement  action or  prosecution  (or
settlement in lieu thereof)  brought by a governmental  authority  relating to a
violation of securities,  fiduciary or criminal laws, or (ii) a civil action (or
settlement in lieu thereof)  brought by  shareholders or investors for violation
of duties owed to the shareholders or investors.

                  3.13  Freedom  to  Operate.  To  the  best  of  the  Company's
knowledge, the conduct by the Company of its businesses,  and the manufacture by
the Company of its products,  does not conflict  with,  infringe upon or violate
any patent,  copyright,  trademark,  registration or other intellectual property
right of any other person or entity.

         4.  Representations  and Warranties of the  Purchasers.  Each Purchaser
severally for itself, and not jointly with the other Purchasers,  represents and
warrants to the Company as follows:

                  4.1  Authorization.  All action on the part of such  Purchaser
and, if applicable,  its officers,  directors and shareholders necessary for the
authorization,  execution,  delivery and  performance  of this Agreement and the
Registration   Rights   Agreement  and  the  consummation  of  the  transactions
contemplated  herein and therein has been taken.  When  executed and  delivered,
each of this Agreement and the Registration Rights Agreement will constitute the
legal, valid and binding obligation of such Purchaser,  enforceable against such
Purchaser  in  accordance  with its  terms,  except  as such may be  limited  by
bankruptcy, insolvency, reorganization or other laws affecting creditors' rights
generally and by general equitable principles.  Such Purchaser has all requisite
corporate power to enter into each of this Agreement and the Registration Rights
Agreement and to carry out and perform its  obligations  under the terms of this
Agreement and the Registration Rights Agreement.

                  4.2  Purchase  Entirely  for Own  Account.  Such  Purchaser is
acquiring the Shares being purchased by it hereunder for investment, for its own
account,  and not for resale or with a view to distribution thereof in violation
of the Securities Act.

                  4.3  Investor  Status;   Etc.  Such  Purchaser  certifies  and
represents  to the Company that at the time such  Purchaser  acquires any of the
Shares,  such Purchaser will be an "Accredited  Investor" as defined in Rule 501
of Regulation D promulgated  under the  Securities Act and was not organized for
the purpose of acquiring the Shares.  Such  Purchaser's  financial  condition is
such that it is able to bear the risk of holding  the  Shares for an  indefinite
period of time and the risk of loss of its entire investment. Such Purchaser has
been afforded the  opportunity to ask questions of and receive  answers from the
management  of  the  Company  concerning  this  investment  and  has  sufficient
knowledge  and  experience  in investing in companies  similar to the Company in
terms of the  Company's  stage of  development  so as to be able to evaluate the
risks and merits of its investment in the Company.

                  4.4 Shares Not Registered. Such Purchaser understands that the
Shares have not been  registered  under the  Securities  Act, by reason of their
issuance  by  the  Company  in  a  transaction   exempt  from  the  registration
requirements of the Securities Act, and that the Shares must continue to be held
by such Purchaser  unless a subsequent  disposition  thereof is registered under
the  Securities  Act  or  is  exempt  from  such  registration.   The  Purchaser
understands  that the  exemptions  from  registration  afforded by Rule 144 (the
provisions of which are known to it) promulgated under the Securities Act depend
on the satisfaction of various conditions, and that, if applicable, Rule 144 may
afford the basis for sales only in limited amounts.

                                       4
<PAGE>


                  4.5 No Conflict.  The execution and delivery of this Agreement
and the Registration  Rights Agreement by such Purchaser and the consummation of
the  transactions  contemplated  hereby and thereby  will not  conflict  with or
result in any violation of or default by such Purchaser  (with or without notice
or lapse  of  time,  or both)  under,  or give  rise to a right of  termination,
cancellation  or  acceleration  of any  obligation  or to a loss  of a  material
benefit  under  (i)  any  provision  of the  organizational  documents  of  such
Purchaser  or (ii) any  agreement or  instrument,  permit,  franchise,  license,
judgment,  order,  statute, law, ordinance,  rule or regulations,  applicable to
such Purchaser or its respective properties or assets.

                  4.6 Brokers. Such Purchaser has not retained, utilized or been
represented  by any  broker  or  finder  in  connection  with  the  transactions
contemplated by this Agreement.

                  4.7   Consents.   All   consents,    approvals,   orders   and
authorizations  required on the part of such  Purchaser in  connection  with the
execution, delivery or performance of this Agreement and the consummation of the
transactions  contemplated herein have been obtained and are effective as of the
Closing Date.

         5. Conditions Precedent.

                  5.1.  Conditions  to  the  Obligation  of  the  Purchasers  to
Consummate  the Closing.  The  obligation of each  Purchaser to  consummate  the
Closing and to purchase and pay for the Shares being purchased by it pursuant to
this  Agreement  is  subject to the  satisfaction  of the  following  conditions
precedent:

                  (a) The representations and warranties contained herein of the
Company  shall be true and correct on and as of the  Closing  Date with the same
force  and  effect  as  though  made on and as of the  Closing  Date  (it  being
understood and agreed by each Purchaser that, in the case of any  representation
and warranty of the Company contained herein which is not hereinabove  qualified
by  application  thereto of a  materiality  standard,  such  representation  and
warranty  need be true and  correct  only in all  material  respects in order to
satisfy as to such  representation or warranty the condition precedent set forth
in the foregoing provisions of this Section 5.1(a)).

                  (b) The Registration Rights Agreement shall have been executed
and delivered by the Company.

                  (c) The Company shall not have been adversely  affected in any
material way prior to the Closing Date; and the Company shall have performed all
obligations  and conditions  herein  required to be performed or observed by the
Company on or prior to the Closing Date.

                  (d)  No   proceeding   challenging   this   Agreement  or  the
transactions  contemplated  hereby,  or seeking to prohibit,  alter,  prevent or
materially  delay the  Closing,  shall  have been  instituted  before any court,
arbitrator or governmental body, agency or official and shall be pending.

                  (e)  The  purchase  of  and  payment  for  the  Shares  by the
Purchasers  shall  not  be  prohibited  by  any  law or  governmental  order  or
regulation.  All necessary consents,  approvals,  licenses,  permits, orders and
authorizations  of,  or  registrations,   declarations  and  filings  with,  any
governmental or administrative agency or of any other person with respect to any
of the  transactions  contemplated  hereby shall have been duly obtained or made
and shall be in full force and effect.

                  (f) All  instruments  and corporate  proceedings in connection
with the  transactions  contemplated  by this Agreement to be consummated at the
Closing shall be satisfactory in form and substance to such Purchaser,  and such
Purchaser  shall  have  received  copies  (executed  or  certified,  as  may

                                       5
<PAGE>


be  appropriate)  of all  documents  which such  Purchaser  may have  reasonably
requested in connection with such transactions.

                  5.2. Conditions to the Obligation of the Company to Consummate
the Closing.  The  obligation  of the Company to  consummate  the Closing and to
issue and sell to each of the Purchasers the Shares to be purchased by it at the
Closing is subject to the satisfaction of the following conditions precedent:

                  (a) The  representations  and warranties  contained  herein of
such Purchaser  shall be true and correct on and as of the Closing Date with the
same force and  effect as though  made on and as of the  Closing  Date (it being
understood and agreed by the Company that, in the case of any representation and
warranty of each Purchaser  contained herein which is not hereinabove  qualified
by  application  thereto of a  materiality  standard,  such  representation  and
warranty  need be true and  correct  only in all  material  respects in order to
satisfy as to such  representation or warranty the condition precedent set forth
in the foregoing provisions of this Section 5.2(a)).

                  (b) The Registration Rights Agreement shall have been executed
and delivered by each Purchaser.

                  (c) The Purchasers  shall have performed all  obligations  and
conditions  herein  required to be performed or observed by the Purchasers on or
prior to the Closing Date.

                  (d)  No   proceeding   challenging   this   Agreement  or  the
transactions  contemplated  hereby,  or seeking to prohibit,  alter,  prevent or
materially  delay the  Closing,  shall  have been  instituted  before any court,
arbitrator or governmental body, agency or official and shall be pending.

                  (e)  The  sale  of the  Shares  by the  Company  shall  not be
prohibited  by any  law or  governmental  order  or  regulation.  All  necessary
consents,  approvals,  licenses,  permits,  orders  and  authorizations  of,  or
registrations, declarations and filings with, any governmental or administrative
agency  or of  any  other  person  with  respect  to  any  of  the  transactions
contemplated  hereby shall have been duly  obtained or made and shall be in full
force and effect.

                  (f) Each of the  Purchasers  shall have executed and delivered
to the Company a Investor  Questionnaire,  in  substantially  the form  attached
hereto as  Exhibit  B,  pursuant  to which  each such  Purchaser  shall  provide
information  necessary to confirm each such Purchaser's status as an "accredited
investor" (as such term is defined in Rule 501 promulgated  under the Securities
Act).

                  (g) Each of the other  Purchasers  shall  have  purchased,  in
accordance with this  Agreement,  the number of shares of Common Stock set forth
opposite its name under the heading "Number of Shares to be Purchased."

                  (h) All  instruments  and corporate  proceedings in connection
with the  transactions  contemplated  by this Agreement to be consummated at the
Closing  shall be  satisfactory  in form and  substance to the Company,  and the
Company shall have received counterpart originals,  or certified or other copies
of all documents,  including  without  limitation  records of corporate or other
proceedings, which it may have reasonably requested in connection therewith.

         6. Transfer; Legends.

                  6.1. Securities Law Transfer Restrictions.  No Purchaser shall
sell,  assign,  pledge,  transfer or  otherwise  dispose or encumber  any of the
Shares  being  purchased  by it  hereunder,  except (i) pursuant to an effective
registration statement under the Securities Act or (ii) pursuant to an available
exemption  from  registration  under the  Securities  Act and  applicable  state
securities  laws  and,  if  requested

                                       6
<PAGE>


by the  Company,  upon  delivery  by such  Purchaser  of an  opinion  of counsel
reasonably  satisfactory to the Company to the effect that the proposed transfer
is exempt  from  registration  under the  Securities  Act and  applicable  state
securities  laws. Any transfer or purported  transfer of the Shares in violation
of this  Section  6.1 shall be voidable by the  Company.  The Company  shall not
register  any  transfer of the Shares in  violation  of this  Section  6.1.  The
Company may, and may instruct any transfer agent for the Company,  to place such
stop transfer  orders as may be required on the transfer books of the Company in
order to ensure compliance with the provisions of this Section 6.1.

                  6.2.  Legends.  Each certificate  requesting any of the Shares
shall be endorsed with a legend in  substantially  the form set forth below, and
each Purchaser covenants that, except to the extent such restrictions are waived
by the  Company,  it shall  not  transfer  the  shares  represented  by any such
certificate  without  complying with the  restrictions on transfer  described in
this Agreement and the legends endorsed on such certificate:

         THE SHARES  REPRESENTED BY THIS  CERTIFICATE  HAVE NOT BEEN  REGISTERED
         UNDER  THE  SECURITIES  ACT OF  1933  AND  MAY  NOT BE  OFFERED,  SOLD,
         ASSIGNED,  PLEDGED  TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE
         OF AN EFFECTIVE REGISTRATION STATEMENT UNDER SAID ACT OR PURSUANT TO AN
         AVAILABLE  EXEMPTION FROM REGISTRATION UNDER SAID ACT AND, IF REQUESTED
         BY THE  COMPANY,  UPON  DELIVERY  OF AN OPINION  OF COUNSEL  REASONABLY
         SATISFACTORY  TO THE COMPANY THAT THE PROPOSED  TRANSFER IS EXEMPT FROM
         SAID ACT.

         7. Termination;  Liabilities  Consequent Thereon. This Agreement may be
terminated and the  transactions  contemplated  hereunder  abandoned at any time
prior to the Closing only as follows:

                  (a) by the  Purchasers,  upon  notice  to the  Company  if the
conditions set forth in Section 5.1 shall not have been satisfied on or prior to
July __, 2000; or

                  (b) by the  Company,  upon  notice  to the  Purchasers  if the
conditions set forth in Section 5.2 shall not have been satisfied on or prior to
July __, 2000; or

                  (c) at any time by mutual  agreement  of the  Company  and the
Purchasers; or

                  (d) by the  Purchasers,  if there  has been any  breach of any
representation or warranty or any material breach of any covenant of the Company
contained  herein  and the same has not been cured  within 15 days after  notice
thereof,  (it being understood and agreed by each Purchaser that, in the case of
any  representation  or warranty of the Company  contained  herein  which is not
hereinabove  qualified by application  thereto of a materiality  standard,  such
representation  or warranty will be deemed to have been breached for purposes of
this  Section  7.1(d) only if such  representation  or warranty was not true and
correct in all material respects at the time such representation or warranty was
made by the Company); or

                  (e) by the  Company,  if  there  has been  any  breach  of any
representation, warranty or any material breach of any covenant of any Purchaser
contained  herein  and the same has not been cured  within 15 days after  notice
thereof (it being  understood and agreed by the Company that, in the case of any
representation  and  warranty of the  Purchaser  contained  herein  which is not
hereinabove  qualified by application  thereto of a materiality  standard,  such
representation  or warranty will be deemed to have been breached for purposes of
this  Section  7.1(e) only if such  representation  or warranty was not true and
correct in all material respects at the time such representation or warranty was
made by such Purchaser).

                                       7
<PAGE>


         Any termination  pursuant to this Section 7 shall be without  liability
on the part of any party,  unless such  termination  is the result of a material
breach  of this  Agreement  by a party  to this  Agreement  in which  case  such
breaching  party  shall  remain  liable  for  such  breach  notwithstanding  any
termination of this Agreement.

         8. Miscellaneous Provisions.

                  8.1 Public Statements or Releases. None of the parties to this
Agreement shall make, issue, or release any announcement,  whether to the public
generally,  or to any of its  suppliers  or  customers,  with  respect  to  this
Agreement  or the  transactions  provided for herein,  or make any  statement or
acknowledgment  of the existence of, or reveal the status of, this  Agreement or
the  transactions  provided for herein,  without the prior  consent of the other
parties,  which shall not be unreasonably  withheld or delayed,  provided,  that
nothing in this Section 8.1 shall prevent any of the parties  hereto from making
such public  announcements as it may consider  necessary in order to satisfy its
legal obligations,  but to the extent not inconsistent with such obligations, it
shall provide the other parties with an opportunity to review and comment on any
proposed public announcement before it is made.

                  8.2 Further  Assurances.  Each party agrees to cooperate fully
with the other party and to execute  such  further  instruments,  documents  and
agreements  and to give such further  written  assurances,  as may be reasonably
requested  by the other party to better  evidence  and reflect the  transactions
described herein and contemplated  hereby,  and to carry into effect the intents
and purposes of this Agreement.

                  8.3 Notification of  Effectiveness of Registration  Statement.
The Company  covenants that it will provide  notice to the  Purchasers  that the
Company's  registration  statement  on Form  S-3  registering  the  shares  sold
hereunder to SWIB has been declared effective by the SEC.

                  8.4 Rights  Cumulative.  Each and all of the  various  rights,
powers and remedies of the parties shall be considered to be cumulative with and
in addition to any other rights, powers and remedies which such parties may have
at law or in  equity  in the  event of the  breach  of any of the  terms of this
Agreement.  The exercise or partial exercise of any right, power or remedy shall
neither  constitute the exclusive  election  thereof nor the waiver of any other
right, power or remedy available to such party.

                  8.5 Pronouns.  All pronouns or any variation  thereof shall be
deemed to refer to the masculine, feminine or neuter, singular or plural, as the
identity of the person, persons, entity or entities may require.

                  8.6 Notices.

                  (a) Any notices, reports or other correspondence  (hereinafter
collectively referred to as "correspondence")  required or permitted to be given
hereunder shall be sent by postage prepaid first class mail, courier or telecopy
or  delivered  by hand to the party to whom such  correspondence  is required or
permitted to be given hereunder. The date of giving any notice shall be the date
of its actual receipt.

                  (b) All  correspondence  to the Company  shall be addressed as
follows:

                           La Jolla Pharmaceutical Company
                           6455 Nancy Ridge Drive
                           San Diego, California  92121
                           Attention: Steven B. Engle
                           Telecopier: (858) 452-6893

                                       8
<PAGE>


                           with a copy to:

                           Gibson, Dunn & Crutcher LLP
                           4 Park Plaza
                           Irvine, California 92614
                           Attention:  Leonard J. McGill
                           Telecopier: (949) 451-4220

                  (c) All  correspondence to any Purchaser shall be sent to such
Purchaser at the address set forth in Exhibit A.

                  (d) Any entity may change the address to which  correspondence
to it is to be addressed by notification as provided for herein.

                  8.7  Captions.  The  captions and  paragraph  headings of this
Agreement are solely for the  convenience  of reference and shall not affect its
interpretation.

                  8.8  Severability.  Should  any  part  or  provision  of  this
Agreement  be held  unenforceable  or in conflict  with the  applicable  laws or
regulations of any jurisdiction, the invalid or unenforceable part or provisions
shall be replaced with a provision which  accomplishes,  to the extent possible,
the  original  business  purpose  of such  part  or  provision  in a  valid  and
enforceable  manner,  and the remainder of this  Agreement  shall remain binding
upon the parties hereto.

                  8.9 Governing Law; Injunctive Relief.

                  (a) This  Agreement  shall be  governed  by and  construed  in
accordance with the internal and substantive laws of the State of California and
without  regard  to  any  conflicts  of  laws  concepts  that  would  apply  the
substantive law of some other jurisdiction.

                  (b) Each of the parties  hereto  acknowledges  and agrees that
damages will not be an adequate  remedy for any material  breach or violation of
this Agreement if such material  breach or violation  would cause  immediate and
irreparable  harm (an  "Irreparable  Breach").  Accordingly,  in the  event of a
threatened or ongoing Irreparable Breach, each party hereto shall be entitled to
seek, in any state or federal court in the State of California, equitable relief
of a kind  appropriate  in light of the  nature  of the  ongoing  or  threatened
Irreparable  Breach,  which relief may  include,  without  limitation,  specific
performance or injunctive relief; provided,  however, that if the party bringing
such action is  unsuccessful  in obtaining the relief  sought,  the moving party
shall pay the  non-moving  party's  costs,  including  actual  attorney's  fees,
incurred in connection  with defending  such action.  Such remedies shall not be
the parties' exclusive remedies,  but shall be in addition to all other remedies
provided in this Agreement.

                  8.10 Waiver. No waiver of any term,  provision or condition of
this Agreement,  whether by conduct or otherwise,  in any one or more instances,
shall be deemed to be, or be construed as, a further or continuing waiver of any
such term, provision or condition or as a waiver of any other term, provision or
condition of this Agreement.

                  8.11 Expenses. Each party will bear its own costs and expenses
in connection with this Agreement.

                  8.12  Assignment.  The rights and  obligations  of the parties
hereto  shall inure to the benefit of and shall be binding  upon the  authorized
successors  and  permitted  assigns of each party.  Neither party may assign its
rights or obligations  under this  Agreement or designate  another person (i) to
perform all or part of its obligations  under this Agreement or (ii) to have all
or part of its rights and benefits  under this  Agreement,  in each case without
the prior written  consent of the other party. In the

                                       9

<PAGE>


event of any  assignment in  accordance  with the terms of this  Agreement,  the
assignee  shall  specifically  assume  and be  bound  by the  provisions  of the
Agreement  by  executing  and  agreeing to an  assumption  agreement  reasonably
acceptable to the other party.

                  8.13 Survival.  The respective  representations and warranties
given by the parties hereto,  and the other  covenants and agreements  contained
herein,  shall survive the Closing Date and the consummation of the transactions
contemplated  herein  for  a  period  of  two  years,   without  regard  to  any
investigation made by any party.

                  8.14 Entire Agreement.  This Agreement along with the exhibits
hereto incorporated herewith constitute the entire agreement between the parties
hereto respecting the subject matter hereof and supersedes all prior agreements,
negotiations,  understandings,  representations  and  statements  respecting the
subject matter hereof,  whether  written or oral. No  modification,  alteration,
waiver or change in any of the terms of this Agreement shall be valid or binding
upon the parties  hereto unless made in writing and duly executed by the Company
and the Majority Purchasers.

         [The remainder of this page has been intentionally left blank;
                            signature page follows]

                                       10
<PAGE>


         IN  WITNESS  WHEREOF,  the  parties  hereto  have  executed  this Stock
Purchase Agreement under seal as of the day and year first above written.

                               LA JOLLA PHARMACEUTICAL COMPANY


                               By:
                                    --------------------------------------------
                                    Name:
                                             -----------------------------------
                                    Title:
                                             -----------------------------------




THE PURCHASER'S SIGNATURE TO THE INVESTOR QUESTIONNAIRE DATED EVEN DATE HEREWITH
SHALL CONSTITUTE THE PURCHASER'S SIGNATURE TO THIS STOCK PURCHASE AGREEMENT.


<PAGE>



                                    Exhibit A

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Purchaser                                                Number of Shares
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<PAGE>



                                    Exhibit C



                          REGISTRATION RIGHTS AGREEMENT

         This  REGISTRATION  RIGHTS  AGREEMENT (this  "Agreement") is made as of
July ___,  2000 by and among (i) La Jolla  Pharmaceutical  Company,  a  Delaware
corporation  (the  "Company"),  (ii) each  person  listed on  Exhibit A attached
hereto (collectively, the "Initial Investors" and each individually, an "Initial
Investor"), and (iii) each person or entity that subsequently becomes a party to
this Agreement pursuant to, and in accordance with, the provisions of Section 12
hereof (each an "Investor Permitted Transferee" and collectively,  the "Investor
Permitted Transferees").

         WHEREAS,  the  Company  has  agreed  to issue  and sell to the  Initial
Investors,  and the Initial  Investors have agreed to purchase from the Company,
______________  shares (the "Purchased  Shares") of the Company's  common stock,
$0.01  par  value  per  share  (the  "Common  Stock"),  all upon the  terms  and
conditions  set forth in that certain Stock  Purchase  Agreement,  dated of even
date  herewith,  between  the  Company  and the  Initial  Investors  (the "Stock
Purchase Agreement"); and

         WHEREAS,  the terms of the Stock  Purchase  Agreement  provide  that it
shall be a condition  precedent to the closing of the  transactions  thereunder,
for the Company and the Initial Investors to execute and deliver this Agreement.

         NOW,  THEREFORE,  in consideration of the premises and mutual covenants
contained herein, the parties hereto hereby agree as follows:

         1.  Definitions.  The following terms shall have the meanings  provided
therefor below or elsewhere in this Agreement as described below:

         "Board" shall mean the board of directors of the Company.

         "Closing"  shall have the  meaning  ascribed  to such term in the Stock
Purchase Agreement.

         "Exchange  Act"  shall mean the  Securities  Exchange  Act of 1934,  as
amended, and all of the rules and regulations promulgated thereunder.

         "Investors"  shall mean,  collectively,  the Initial  Investors and the
Investor Permitted  Transferees;  provided,  however,  that the term "Investors"
shall not include any of the Initial Investors or any of the Investor  Permitted
Transferees that ceases to own or hold any Purchased Shares.

         "Majority  Holders"  shall  mean,  at the  relevant  time of  reference
thereto, those Investors holding and/or having the right to acquire, as the case
may be, more than fifty percent (50%) of the  Registrable  Shares held by all of
the Investors.

         "Qualifying  Holder" shall have the meaning ascribed thereto in Section
12 hereof.

         "Registrable  Shares"  shall  mean  the  Purchased  Shares,   provided,
however, such term shall not, after the Mandatory Registration Termination Date,
include any of the  Purchased  Shares that  become or have become  eligible  for
resale pursuant to Rule 144 or pursuant to Regulation S.

         "Rule 144" shall mean Rule 144 promulgated under the Securities Act and
any successor or substitute rule, law or provision.
<PAGE>


         "SEC" shall mean the Securities and Exchange Commission.

         "Securities Act" shall mean the Securities Act of 1933, as amended, and
all of the rules and regulations promulgated thereunder.

         2.  Effectiveness;  Termination.  This Agreement shall become effective
and legally binding only if the Closing  occurs.  This Agreement shall terminate
and be of no further force or effect, automatically and without any action being
required  of any  party  hereto,  upon the  termination  of the  Stock  Purchase
Agreement pursuant to Section 8 thereof.

         3. Mandatory Registration.

                  (a)  Within ten (10)  business  days  after the  Closing,  the
Company will prepare and file with the SEC a registration  statement on Form S-3
for the purpose of registering  under the Securities Act all of the  Registrable
Shares  for  resale  by,  and for the  account  of,  the  Investors  as  selling
stockholders  thereunder  (the  "Registration   Statement").   The  Registration
Statement  shall  permit  the  Investors  to offer  and sell,  on a  delayed  or
continuous  basis pursuant to Rule 415 under the  Securities  Act, any or all of
the Registrable  Shares.  The Company agrees to use reasonable  efforts to cause
the  Registration  Statement  to become  effective as soon as  practicable.  The
Company shall be required to keep the  Registration  Statement  effective  until
such date that is the earlier of (i) the date when all of the Registrable Shares
registered thereunder shall have been sold or (ii) the second anniversary of the
Closing,  subject to  extension  as set forth  below  (such date is  referred to
herein  as the  "Mandatory  Registration  Termination  Date").  Thereafter,  the
Company  shall be  entitled  to  withdraw  the  Registration  Statement  and the
Investors  shall have no further  right to offer or sell any of the  Registrable
Shares  pursuant  to the  Registration  Statement  (or any  prospectus  relating
thereto).  In  the  event  the  right  of  the  selling  Investors  to  use  the
Registration  Statement  (and the  prospectus  relating  thereto)  is delayed or
suspended  pursuant to Sections 5(c) or 11 hereof, the Company shall be required
to  extend  the  Mandatory  Registration  Termination  Date  beyond  the  second
anniversary  of the  Closing  by the  same  number  of  days as  such  delay  or
Suspension Period (as defined in Section 11 hereof).

                  (b) The offer and sale of the  Registrable  Shares pursuant to
the Registration Statement shall not be underwritten.

                                       2
<PAGE>


         4. "Piggyback" Registration Rights.

                  (a)  If,  at  any  time  after  the   Mandatory   Registration
Termination Date, the Company proposes to register any of its Common Stock under
the Securities  Act,  whether as a result of a primary or secondary  offering of
Common  Stock or pursuant  to  registration  rights  granted to holders of other
securities of the Company (but  excluding in all cases any  registrations  to be
effected on Forms S-4 or S-8 or other applicable  successor Forms),  the Company
shall, each such time, give to the Investors holding  Registrable Shares written
notice of its intent to do so.  Upon the  written  request of any such  Investor
given  within 20 days after the giving of any such  notice by the  Company,  the
Company  shall  use  reasonable   efforts  to  cause  to  be  included  in  such
registration  the  Registrable  Shares of such selling  Investor,  to the extent
requested to be registered;  provided that (i) the number of Registrable  Shares
proposed to be sold by such selling  Investor is equal to at least  seventy-five
percent  (75%) of the  total  number  of  Registrable  Shares  then held by such
participating selling Investor,  (ii) such selling Investor agrees to sell those
of its Registrable Shares to be included in such registration in the same manner
and on the same terms and  conditions  as the other shares of Common Stock which
the Company  proposes to register,  and (iii) if the  registration is to include
shares of Common  Stock to be sold for the  account of the  Company or any party
exercising demand  registration  rights pursuant to any other agreement with the
Company,  the proposed managing  underwriter does not advise the Company that in
its opinion the inclusion of such selling Investor's Registrable Shares (without
any  reduction in the number of shares to be sold for the account of the Company
or such  party  exercising  demand  registration  rights)  is  likely  to affect
materially  and adversely the success of the offering or the price that would be
received  for any shares of Common  Stock  offered,  in which case the rights of
such selling Investor shall be as provided in Section 4(b) hereof.

                                       3
<PAGE>


                  (b) If a registration pursuant to Section 4(a) hereof involves
an underwritten  offering and the managing  underwriter shall advise the Company
in writing that, in its opinion,  the number of shares of Common Stock requested
by the  Investors  to be  included  in such  registration  is  likely  to affect
materially  and adversely the success of the offering or the price that would be
received  for any  shares  of  Common  Stock  offered  in such  offering,  then,
notwithstanding anything in Section 4(a) to the contrary, the Company shall only
be  required  to  include in such  registration,  to the extent of the number of
shares of Common  Stock  which the  Company  is so  advised  can be sold in such
offering,  (i)  first,  the  number of shares of  Common  Stock  proposed  to be
included  in such  registration  for  the  account  of the  Company  and/or  any
stockholders  of the Company  (other  than the  Investors)  that have  exercised
demand  registration  rights,  in accordance with the  priorities,  if any, then
existing  among  the  Company  and/or  such  stockholders  of the  Company  with
registration  rights (other than the Investors),  and (ii) second, the shares of
Common  Stock  requested  to be  included  in  such  registration  by all  other
stockholders of the Company who have piggyback  registration  rights (including,
without  limitation,  the  Investors),  pro rata among  such other  stockholders
(including,  without  limitation,  the  Investors) on the basis of the number of
shares of  Common  Stock  that each of them  requested  to be  included  in such
registration.

                  (c) In connection with any offering  involving an underwriting
of shares, the Company shall not be required under Section 4 hereof or otherwise
to include the Registrable  Shares of any Investor  therein unless such Investor
accepts and agrees to the terms of the  underwriting,  which shall be reasonable
and customary,  as agreed upon between the Company and the underwriters selected
by the Company.

         5.  Obligations  of the  Company.  In  connection  with  the  Company's
obligation under Section 3 and 4 hereof to file the Registration  Statement with
the SEC and to use its best  efforts  to cause  the  Registration  Statement  to
become effective as soon as practicable,  the Company shall, as expeditiously as
reasonably possible:

                  (a)  Prepare  and  file  with  the  SEC  such  amendments  and
         supplements to the  Registration  Statement and the prospectus  used in
         connection  therewith as may be necessary to comply with the provisions
         of  the  Securities  Act  with  respect  to  the   disposition  of  all
         Registrable Shares covered by the Registration Statement;

                  (b) Furnish to the selling  Investors such number of copies of
         a prospectus,  including a preliminary  prospectus,  in conformity with
         the  requirements  of the  Securities  Act,  and such  other  documents
         (including,  without limitation,  prospectus amendments and supplements
         as are prepared by the Company in  accordance  with Section 5(a) above)
         as the selling Investors may reasonably  request in order to facilitate
         the disposition of such selling Investors' Registrable Shares;

                  (c)  Notify  the  selling  Investors,   at  any  time  when  a
         prospectus  relating to the  Registration  Statement  is required to be
         delivered  under the Securities Act, of the happening of any event as a
         result  of  which  the  prospectus  included  in  or  relating  to  the
         Registration  Statement contains an untrue statement of a material fact
         or  omits  any  fact  necessary  to make  the  statements  therein  not
         misleading;  and,  thereafter,  the Company will promptly prepare (and,
         when completed,  give notice to each selling  Investor) a supplement or
         amendment to such  prospectus so that,  as thereafter  delivered to the
         purchasers of such Registrable Shares, such prospectus will not contain
         an  untrue  statement  of a  material  fact or omit to  state  any fact
         necessary to make the statements therein not misleading;  provided that
         upon such  notification by the Company,  the selling Investors will not
         offer or sell  Registrable  Shares  until the Company has  notified the
         selling  Investors  that it has prepared a  supplement  or amendment to
         such prospectus and delivered copies of such supplement or amendment to
         the selling  Investors (it being  understood  and agreed by the Company
         that the foregoing proviso shall in no way diminish or otherwise impair
         the Company's  obligation to promptly prepare a

                                       4
<PAGE>


         prospectus  amendment or supplement  as above  provided in this Section
         5(c) and  deliver  copies of same as above  provided  in  Section  5(b)
         hereof); and

                  (e)  Use  commercially  reasonable  efforts  to  register  and
         qualify the Registrable  Shares covered by the  Registration  Statement
         under such other  securities or Blue Sky laws of such  jurisdictions as
         shall be reasonably  appropriate  in the opinion of the Company and the
         managing  underwriters,  if any, provided that the Company shall not be
         required in connection  therewith or as a condition  thereto to qualify
         to do  business  or to file a general  consent to service of process in
         any  such  states  or   jurisdictions,   and   provided   further  that
         (notwithstanding  anything  in  this  Agreement  to the  contrary  with
         respect to the bearing of expenses) if any jurisdiction in which any of
         such Registrable  Shares shall be qualified shall require that expenses
         incurred  in  connection  with the  qualification  therein  of any such
         Registrable Shares be borne by the selling Investors,  then the selling
         Investors shall, to the extent required by such jurisdiction, pay their
         pro rata share of such qualification expenses.

         6.  Furnish  Information.  It shall  be a  condition  precedent  to the
obligations  of the Company to take any action  pursuant to this  Agreement that
the selling  Investors shall furnish to the Company such  information  regarding
them and the securities held by them as the Company shall reasonably request and
as shall be required in order to effect any registration by the Company pursuant
to this Agreement.

         7. Expenses of Registration.  All expenses  incurred in connection with
the registration of the Registrable Shares pursuant to this Agreement (excluding
underwriting,  brokerage and other selling commissions and discounts), including
without limitation all registration and qualification and filing fees, printing,
and fees and  disbursements  of counsel for the  Company,  shall be borne by the
Company.

         8. Delay of  Registration.  The Investors  shall not take any action to
restrain,  enjoin or  otherwise  delay  any  registration  as the  result of any
controversy   which  might  arise  with   respect  to  the   interpretation   or
implementation of this Agreement.

         9. Indemnification.

                  (a) To the extent permitted by law, the Company will indemnify
and hold harmless each selling Investor,  any investment  banking firm acting as
an underwriter for the selling Investors,  any broker/dealer acting on behalf of
any selling  Investors  and each officer and director of such selling  Investor,
such underwriter,  such broker/dealer and each person, if any, who controls such
selling  Investor,  such underwriter or broker/dealer  within the meaning of the
Securities Act,  against any losses,  claims,  damages or liabilities,  joint or
several, to which they may become subject under the Securities Act or otherwise,
insofar as such losses,  claims,  damages or liabilities  (or actions in respect
thereof) arise out of or are based upon any untrue or alleged  untrue  statement
of any material fact contained in the Registration Statement, in any preliminary
prospectus  or  final  prospectus  relating  thereto  or in  any  amendments  or
supplements to the Registration  Statement or any such preliminary prospectus or
final  prospectus,  or arise out of or are based  upon the  omission  or alleged
omission to state  therein a material  fact  required to be stated  therein,  or
necessary to make the statements therein not misleading; and will reimburse such
selling Investor, such underwriter,  broker/dealer or such officer,  director or
controlling person for any legal or other expenses  reasonably  incurred by them
in connection  with  investigating  or defending any such loss,  claim,  damage,
liability or action;  provided,  however, that the indemnity agreement contained
in this Section 9(a) shall not apply to amounts paid in  settlement  of any such
loss, claim, damage,  liability or action if such settlement is effected without
the consent of the Company (which consent shall not be  unreasonably  withheld),
nor shall the  Company  be  liable in any such case for any such  loss,  damage,
liability  or action to the  extent  that it arises  out of or is based  upon an
untrue statement or alleged untrue statement or omission made in connection with
the  Registration  Statement,  any  preliminary  prospectus or final  prospectus
relating thereto or any amendments or supplements to the Registration  Statement
or any such preliminary prospectus or final prospectus,  in

                                       5
<PAGE>


reliance upon and in conformity with written information furnished expressly for
use in  connection  with the  Registration  Statement  or any  such  preliminary
prospectus or final  prospectus by the selling  Investors,  any  underwriter for
them or controlling person with respect to them.

                  (b) To the extent permitted by law, each selling Investor will
severally and not jointly  indemnify and hold harmless the Company,  each of its
directors, each of its officers who have signed the Registration Statement, each
person,  if any, who controls the Company  within the meaning of the  Securities
Act, any investment  banking firm acting as  underwriter  for the Company or the
selling Investors,  or any broker/dealer  acting on behalf of the Company or any
selling Investors,  and all other selling Investors against any losses,  claims,
damages  or  liabilities  to which the  Company or any such  director,  officer,
controlling person, underwriter, or broker/dealer or such other selling Investor
may become subject to, under the  Securities  Act or otherwise,  insofar as such
losses, claims, damages or liabilities (or actions in respect thereto) arise out
of or are based upon any untrue or alleged untrue statement of any material fact
contained in the Registration  Statement or any preliminary  prospectus or final
prospectus,  relating  thereto  or in  any  amendments  or  supplements  to  the
Registration  Statement or any such preliminary  prospectus or final prospectus,
or arise out of or are based  upon the  omission  or alleged  omission  to state
therein a material fact  required to be stated  therein or necessary to make the
statements  therein not  misleading,  in each case to the extent and only to the
extent that such untrue  statement  or alleged  untrue  statement or omission or
alleged  omission was made in the  Registration  Statement,  in any  preliminary
prospectus  or  final  prospectus  relating  thereto  or in  any  amendments  or
supplements to the Registration  Statement or any such preliminary prospectus or
final  prospectus,  in reliance upon and in conformity with written  information
furnished  by the selling  Investor  expressly  for use in  connection  with the
Registration Statement,  or any preliminary prospectus or final prospectus;  and
such selling  Investor  will  reimburse any legal or other  expenses  reasonably
incurred  by the  Company or any such  director,  officer,  controlling  person,
underwriter,   broker/dealer  or  other  selling  Investor  in  connection  with
investigating or defending any such loss,  claim,  damage,  liability or action,
provided,  however,  that the liability of each selling Investor hereunder shall
be limited to the proceeds (net of underwriting  discounts and  commissions,  if
any)  received by such  selling  Investor  from the sale of  Registrable  Shares
covered by the Registration Statement, and provided,  further, however, that the
indemnity  agreement  contained  in this Section 9(b) shall not apply to amounts
paid in settlement of any such loss, claim, damage,  liability or action if such
settlement is effected without the consent of those selling  Investor(s) against
which the  request  for  indemnity  is being made  (which  consent  shall not be
unreasonably withheld).

                  (c) Promptly after receipt by an indemnified  party under this
Section 9 of notice of the commencement of any action,  such  indemnified  party
will, if a claim in respect thereof is to be made against any indemnifying party
under  this  Section  9,  notify  the  indemnifying  party  in  writing  of  the
commencement  thereof  and the  indemnifying  party  shall  have  the  right  to
participate in and, to the extent the indemnifying  party desires,  jointly with
any other  indemnifying  party similarly  noticed,  to assume at its expense the
defense thereof with counsel mutually  satisfactory to the indemnifying  parties
with the consent of the indemnified party which consent will not be unreasonably
withheld,  conditioned  or  delayed.  In the event that the  indemnifying  party
assumes any such defense,  the indemnified party may participate in such defense
with its own counsel and at its own expense, provided, however, that the counsel
for the indemnifying  party shall act as lead counsel in all matters  pertaining
to such defense or  settlement  of such claim and the  indemnifying  party shall
only pay for such indemnified  party's expenses for the period prior to the date
of its  participation  on such  defense.  The failure to notify an  indemnifying
party  promptly of the  commencement  of any such action,  if prejudicial to his
ability to defend such  action,  shall  relieve such  indemnifying  party of any
liability to the indemnified  party under this Section 9, but the omission so to
notify the indemnifying party will not relieve him of any liability which he may
have to any indemnified party otherwise other than under this Section 9.

                  (d)  Notwithstanding  anything  to the  contrary  herein,  the
indemnifying party shall not be entitled to settle any claim, suit or proceeding
unless in connection  with such  settlement  the  indemnified  party receives an
unconditional  release with respect to the subject matter of such claim, suit or
proceeding  and such  settlement  does not contain any admission of fault by the
indemnified party.

                                       6
<PAGE>


         10. Reports under the Exchange Act. With a view to making  available to
the  Investors  the benefits of Rule 144 and any other rule or regulation of the
SEC that may at any time permit the  Investors to sell the  Purchased  Shares to
the  public  without  registration,  the  Company  agrees  to  use  commercially
reasonable efforts: (i) to make and keep public information available,  as those
terms are understood and defined in the General Instructions to Form S-3, or any
successor or  substitute  form,  and in Rule 144, (ii) to file with the SEC in a
timely manner all reports and other documents  required to be filed by an issuer
of securities  registered under the Securities Act or the Exchange Act, (iii) as
long as any Investor owns any Purchased  Shares, to furnish in writing upon such
Investor's  request a written statement by the Company that it has complied with
the  reporting  requirements  of  Rule  144  and of the  Securities  Act and the
Exchange  Act, and to furnish to such  Investor a copy of the most recent annual
or quarterly  report of the  Company,  and such other  reports and  documents so
filed by the Company as may be reasonably requested in availing such Investor of
any rule or regulation of the SEC  permitting  the selling of any such Purchased
Shares without registration and (iv) undertake any additional actions reasonably
necessary to maintain the availability of the Registration  Statement or the use
of Rule 144.

         11. Deferral and Lock-up. Notwithstanding anything in this Agreement to
the  contrary,  if  the  Company  shall  furnish  to  the  selling  Investors  a
certificate  signed by the President or Chief  Executive  Officer of the Company
stating  that the Board of  Directors  of the  Company  has made the good  faith
determination   (i)  that  continued  use  by  the  selling   Investors  of  the
Registration  Statement for purposes of effecting offers or sales of Registrable
Shares  pursuant  thereto would  require,  under the Securities  Act,  premature
disclosure in the Registration Statement (or the prospectus relating thereto) of
material,   nonpublic  information  concerning  the  Company,  its  business  or
prospects or any proposed material transaction  involving the Company, (ii) that
such  premature  disclosure  would be  materially  adverse to the  Company,  its
business or prospects or any such proposed  material  transaction  or would make
the  successful  consummation  by the Company of any such  material  transaction
significantly  less likely and (iii) that it is  therefore  essential to suspend
the use by the  Investors of such  Registration  Statement  (and the  prospectus
relating  thereto)  for  purposes of  effecting  offers or sales of  Registrable
Shares  pursuant  thereto,  then the right of the selling  Investors  to use the
Registration  Statement  (and the prospectus  relating  thereto) for purposes of
effecting  offers  or sales of  Registrable  Shares  pursuant  thereto  shall be
suspended  for not more than two 30-day  periods in a twelve  month  period (the
"Suspension  Period(s)")  after  delivery  by the  Company  of  the  certificate
referred to above in this Section 11. During the Suspension Period,  none of the
Investors shall offer or sell any Registrable  Shares pursuant to or in reliance
upon the Registration Statement (or the prospectus relating thereto).

         12. Transfer of Registration Rights. None of the rights of any Investor
under this  Agreement  shall be transferred or assigned to any person unless (i)
such  person is a  Qualifying  Holder (as defined  below),  and (ii) such person
agrees to become a party to, and bound by, all of the terms and  conditions  of,
this  Agreement by duly executing and delivering to the Company an Instrument of
Adherence in the form attached as Exhibit B hereto. For purposes of this Section
12, the term "Qualifying  Holder" shall mean, with respect to any Investor,  (i)
any partner thereof, (ii) any corporation,  partnership controlling,  controlled
by, or under common control with, such Investor or any partner thereof, or (iii)
any  other  direct  transferee  from  such  Investor  of at  least  50% of those
Registrable  Shares held or that may be acquired by such  Investor.  None of the
rights of any Investor under this Agreement  shall be transferred or assigned to
any Person (including,  without  limitation,  a Qualifying Holder) that acquires
Registrable  Shares  in the event  that and to the  extent  that such  Person is
eligible  to resell  such  Registrable  Shares  pursuant  to Rule  144(k) of the
Securities Act or may otherwise  resell such  Registrable  Shares pursuant to an
exemption from the registration provisions of the Securities Act.

         13. Entire  Agreement.  This Agreement and the exhibits attached hereto
and  incorporated  herewith  constitute  and contains the entire  agreement  and
understanding  of the parties with respect to the subject matter hereof,  and it
also supersedes any and all prior  negotiations,  correspondence,  agreements or
understandings with respect to the subject matter hereof.

                                       7
<PAGE>


         14. Miscellaneous.

         This  Agreement  may not be  amended,  modified or  terminated,  and no
rights or  provisions  may be waived,  except  with the  written  consent of the
Majority Holders and the Company.

         This  Agreement  shall be governed  by and  construed  and  enforced in
accordance  with the laws of California,  and shall be binding upon and inure to
the  benefit  of  the  parties  hereto  and  their  respective  heirs,  personal
representatives,  successors or assigns,  provided that the terms and conditions
of Section 12 hereof are satisfied.  This  Agreement  shall also be binding upon
and  inure to the  benefit  of any  transferee  of any of the  Purchased  Shares
provided  that the terms and  conditions  of Section  12 hereof  are  satisfied.
Notwithstanding  anything in this Agreement to the contrary,  if at any time any
Investor shall cease to own any Purchased Shares,  all of such Investor's rights
under this Agreement shall immediately terminate.

         (i)  Any  notices,   reports  or  other   correspondence   (hereinafter
collectively referred to as "correspondence")  required or permitted to be given
hereunder  shall be sent by  courier  (overnight  or same  day) or  telecopy  or
delivered  by hand to the  party to whom  such  correspondence  is  required  or
permitted to be given hereunder. The date of giving any notice shall be the date
of its actual receipt.

                           (ii)  All  correspondence  to the  Company  shall  be
                  addressed as follows:

                                    La Jolla Pharmaceutical Company
                                    6455 Nancy Ridge Drive
                                    San Diego, CA 92121
                                    Attention:  President
                                    Telecopier: (858) 626-2851

                                    with a copy to:

                                    Gibson, Dunn & Crutcher LLP
                                    4 Park Plaza
                                    Irvine, California 92614
                                    Attention:  Leonard J. McGill
                                    Telecopier: (949) 451-4220

                           (iii) All  correspondence  to any  Investor  shall be
                  sent to such Purchaser at the address set forth in Exhibit A.

         Any entity may change the address to which  correspondence  to it is to
be addressed by notification as provided for herein.

         The  parties  acknowledge  and agree that in the event of any breach of
this  Agreement,  remedies  at law may be  inadequate,  and each of the  parties
hereto shall be entitled to seek specific  performance of the obligations of the
other parties hereto and such appropriate injunctive relief as may be granted by
a court of competent jurisdiction.

         This Agreement may be executed in a number of counterparts, an of which
together shall for all purposes  constitute  one  Agreement,  binding on all the
parties  hereto  notwithstanding  that all such parties have not signed the same
counterpart.

             [The remainder of this page has been intentionally left
                        blank; signature page follows.]

                                       8
<PAGE>


IN WITNESS WHEREOF,  the parties hereto have executed this  Registration  Rights
Agreement as of the date and year first above written.


                                    LA JOLLA PHARMACEUTICAL COMPANY


                                    By:
                                          --------------------------------------
                                          Name:
                                                   -----------------------------
                                          Title:
                                                   -----------------------------




THE INITIAL INVESTOR'S  SIGNATURE TO THE INVESTOR  QUESTIONNAIRE DATED EVEN DATE
HEREWITH SHALL CONSTITUTE THE INITIAL INVESTOR'S  SIGNATURE TO THIS REGISTRATION
RIGHTS AGREEMENT.


<PAGE>


                                    EXHIBIT A

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Purchaser                                                Number of Shares
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<PAGE>


                                    Exhibit B

                             Instrument of Adherence

         Reference is hereby made to that certain Registration Rights Agreement,
dated as of July ___, 2000, among La Jolla  Pharmaceutical  Company,  a Delaware
corporation (the "Company"),  the Initial  Investors and the Investor  Permitted
Transferees,  as  amended  and in effect  from  time to time (the  "Registration
Rights Agreement").  Capitalized terms used herein without definition shall have
the respective meanings ascribed thereto in the Registration Rights Agreement.

         The undersigned,  in order to become the owner or holder of ___________
shares of common stock, par value $0.01 per share (the "Common  Stock"),  of the
Company, hereby agrees that, from and after the date hereof, the undersigned has
become  a party to the  Registration  Rights  Agreement  in the  capacity  of an
Investor Permitted Transferee, and is entitled to all of the benefits under, and
is subject to all of the obligations, restrictions and limitations set forth in,
the  Registration  Rights  Agreement that are  applicable to Investor  Permitted
Transferees.  This  Instrument of Adherence shall take effect and shall become a
part of the Registration Rights Agreement immediately upon execution.

         Executed  under seal as of the date set forth  below  under the laws of
the State of California.



                           Signature:
                                     ----------------------------------------
                                           Name:
                                                   --------------------------
                                           Title:
                                                   --------------------------


Accepted:

La Jolla Pharmaceutical Company


By:
   ---------------------------------------------
         Name:
                  ------------------------------
         Title:
                  ------------------------------


Date:
     -------------------------



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