LA JOLLA PHARMACEUTICAL CO
SC 13G, 2000-09-11
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  ------------

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                               (Amendment No. __ )

                         La Jolla Pharmaceutical Company
--------------------------------------------------------------------------------
                                (Name of issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of class of securities)

                                    503459109
--------------------------------------------------------------------------------
                                 (CUSIP number)

                                 August 28, 2000
--------------------------------------------------------------------------------
             (Date of Event which requires filing of this Statement)

     Check the appropriate box to designate the rule pursuant to which this
                               schedule is filed:

                               / / Rule 13d-1 (b)
                               /X/ Rule 13d-1 (c)
                               / / Rule 13d-1 (d)
<PAGE>
---------------------------------
      CUSIP No. 503459109
---------------------------------



-------- -----------------------------------------------------------------------
1        NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Bank AG
-------- -----------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                       (b) / /
-------- -----------------------------------------------------------------------
3        SEC USE ONLY

-------- -----------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
---------------------------- ------ --------------------------------------------
NUMBER OF SHARES             5      SOLE VOTING POWER
                                    0
                             ------ --------------------------------------------
BENEFICIALLY OWNED BY               SHARED VOTING POWER
                             6      3,044,783*
                             ------ --------------------------------------------
EACH REPORTING                      SOLE DISPOSITIVE POWER
                             7      0
                             ------ --------------------------------------------
PERSON WITH                         SHARED DISPOSITIVE POWER
                             8      3,044,783*
-------- -----------------------------------------------------------------------
 9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         3,044,783*
-------- -----------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                / /
-------- -----------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         12.4%**
-------- -----------------------------------------------------------------------
12       TYPE OF REPORTING PERSON

         HC, BK, CO
-------- -----------------------------------------------------------------------

* Included in this figure are the securities  reported by Deutsche Funds Holding
GmbH and DWS Investment S.A., Luxembourg on the following cover pages.

** Included in this  percentage  is the  percentage  of  securities  reported by
Deutsche Funds Holding GmbH and DWS Investment S.A., Luxembourg on the following
cover pages.
<PAGE>
---------------------------------
      CUSIP No. 503459109
---------------------------------



-------- -----------------------------------------------------------------------
   1     NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Deutsche Funds Holding GmbH
-------- -----------------------------------------------------------------------
   2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                       (b) / /
-------- -----------------------------------------------------------------------
   3     SEC USE ONLY

-------- -----------------------------------------------------------------------
   4     CITIZENSHIP OR PLACE OF ORGANIZATION

         Federal Republic of Germany
------------------------------ ------ ------------------------------------------
NUMBER OF SHARES                 5    SOLE VOTING POWER
                                      0
                               ------ ------------------------------------------
BENEFICIALLY OWNED BY                 SHARED VOTING POWER
                                 6    2,260,300*
                               ------ ------------------------------------------
EACH REPORTING                        SOLE DISPOSITIVE POWER
                                 7    0
                               ------ ------------------------------------------
PERSON WITH                           SHARED DISPOSITIVE POWER
                                 8    2,260,300*
-------- -----------------------------------------------------------------------
   9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,260,300*
-------- -----------------------------------------------------------------------
  10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                / /
-------- -----------------------------------------------------------------------
  11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         9.2%**
-------- -----------------------------------------------------------------------
  12     TYPE OF REPORTING PERSON

         HC
-------- -----------------------------------------------------------------------

*Included in this figure are the  securities  reported by DWS  Investment  S.A.,
Luxembourg on the following cover page.

**Included in this  percentage is the  percentage of securities  reported by DWS
Investment S.A., Luxembourg.

<PAGE>
---------------------------------
      CUSIP No. 503459109
---------------------------------


-------- -----------------------------------------------------------------------
   1     NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         DWS Investment S.A., Luxembourg
-------- -----------------------------------------------------------------------
   2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP              (a) / /
                                                                       (b) / /
-------- -----------------------------------------------------------------------
   3     SEC USE ONLY

-------- -----------------------------------------------------------------------
   4     CITIZENSHIP OR PLACE OF ORGANIZATION

         [Federal Republic of Germany]
------------------------------ ------ ------------------------------------------
NUMBER OF SHARES                 5    SOLE VOTING POWER
                                      0
                               ------ ------------------------------------------
BENEFICIALLY OWNED BY                 SHARED VOTING POWER
                                 6    2,260,300
                               ------ ------------------------------------------
EACH REPORTING                        SOLE DISPOSITIVE POWER
                                 7    0
                               ------ ------------------------------------------
PERSON WITH                           SHARED DISPOSITIVE POWER
                                 8    2,260,300
-------- -----------------------------------------------------------------------
   9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         2,260,300
-------- -----------------------------------------------------------------------
  10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES                                                / /
-------- -----------------------------------------------------------------------
  11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         9.2%
-------- -----------------------------------------------------------------------
  12     TYPE OF REPORTING PERSON

         CO
-------- -----------------------------------------------------------------------

<PAGE>
Item 1(a).        Name of Issuer:

                  La Jolla Pharmaceutical Company (the "Issuer")

Item 1(b).        Address of Issuer's Principal Executive Offices:

                  The address of the  Issuer's  principal  executive  offices is
6455 Nancy Ridge Drive, San Diego, CA 92121.

Item 2(a).        Name of Person Filing:

                  This  statement  is  filed  on  behalf  of  Deutsche  Bank  AG
("DBAG"),  Deutsche  Funds  Holding  GmbH  ("DWSG"),  and DWS  Investment  S.A.,
Luxembourg (DWSI", and together with DBAG and DWSG, the "Reporting Persons").

Item 2(b).        Address of Principal Business Office or, if none, Residence:

                  The principal  place of business of DBAG is  Taunusanlage  12,
D-60325, Frankfurt am Main, Federal Republic of Germany.

                  The principal place of business of DWSG is Feldbergstrasse 22,
60323, Frankfurt, Federal Republic of Germany.

                  The principal place of business of DWSI is 2, Boulevard Konrad
Adenauer, 1115 Luxembourg.

Item 2(c).        Citizenship:

                  The citizenship of each of the Reporting  Persons is set forth
on the applicable cover page.

Item 2(d).        Title of Class of Securities:

                  The title of the  securities  is  Common  Stock  (the  "Common
Stock").

Item 2(e).        CUSIP Number:

                  The  CUSIP  number  of the  Common  Stock is set forth on each
cover page.

Item 3.           If this  statement  is filed  pursuant to Rules  13d-1(b),  or
                  13d-2(b) or (c), check whether the person filing is a:

                  (a)  / /  Broker or dealer  registered under section 15 of the
                            Act;

                  (b)  / /  Bank as defined in section 3(a)(6) of the Act;

                  (c)  / /  Insurance  Company as defined in section 3(a)(19) of
                            the Act;

                  (d)  / /  Investment Company registered under section 8 of the
                            Investment Company Act of 1940;

                  (e)  / /  An investment  adviser in accordance with Rule 13d-1
                            (b)(1)(ii)(E);

                  (f)  / /  An  employee  benefit  plan,  or  endowment  fund in
                            accordance with Rule 13d-1 (b)(1)(ii)(F);

                  (g)  / /  A  parent  holding  company  or  control  person  in
                            accordance with Rule 13d-1 (b)(1)(ii)(G);

                  (h)  / /  A savings  association as defined in section 3(b) of
                            the Federal Deposit Insurance Act;

                  (i)  / /  A church plan that is excluded  from the  definition
                            of an investment  company under section  3(c)(14) of
                            the Investment Company Act of 1940;

                  (j)  / /  Group, in accordance with Rule 13d-1 (b)(1)(ii)(J).

                  If this  statement is filed  pursuant to Rule 13d-1 (c), check
this box. /X/

Item 4.           Ownership.

                  (a)      Amount beneficially owned:

                           Each of the Reporting  Persons owns the amount of the
                  Common Stock as set forth on the applicable cover page.

                  (b)      Percent of class:

                           Each of the Reporting  Persons owns the percentage of
                  the Common Stock as set forth on the applicable cover page.

                  (c)      Number of shares as to which such person has:

                           (i)      sole power to vote or to direct the vote:

                                    Each of the  Reporting  Persons has the sole
                           power to vote or direct the vote of the Common  Stock
                           as set forth on the applicable cover page.

                           (ii)     shared power to vote or to direct the vote:

                                    Each of the Reporting Persons has the shared
                           power to vote or direct the vote of the Common  Stock
                           as set forth on the applicable cover page.

                           (iii)    sole  power  to  dispose  or to  direct  the
                                    disposition of:

                                    Each of the  Reporting  Persons has the sole
                           power to  dispose or direct  the  disposition  of the
                           Common  Stock as set  forth on the  applicable  cover
                           page.

                           (iv)     shared  power to  dispose  or to direct  the
                                    disposition of:

                                    Each of the Reporting Persons has the shared
                           power to  dispose or direct  the  disposition  of the
                           Common  Stock as set  forth on the  applicable  cover
                           page.

Item 5.           Ownership of Five Percent or Less of a Class.

                  Not applicable.

[Item 6].         Ownership  of More than  Five  Percent  on  Behalf of  Another
                  Person.

                  [Mutual  fund  clients  of  the  Reporting  Persons  have  the
ultimate  right to any dividends from the Common Stock and the proceeds from the
sale of the Common Stock.]

Item 7.           Identification  and  Classification  of the  Subsidiary  Which
                  Acquired the Security  Being Reported on by the Parent Holding
                  Company.

                  The following are  subsidiaries of DBAG and/or DWSG which hold
Common Stock included in the figures on the cover pages:  DWS  Investment  GmbH,
Deutsche    Vermogensbildungsgesellschaft   mbH,   Deutsche   Asset   Management
Investmentgesellschaft GmbH and Deutsche Asset Management International GmbH.

Item 8.           Identification and Classification of Members of the Group.

                  Not applicable.

Item 9.           Notice of Dissolution of Group.

                  Not applicable.

Item 10.          Certification.

                  By signing  below I certify  that, to the best of my knowledge
and belief, the securities  referred to above were not acquired and are not held
for the purpose of or with the effect of changing or influencing  the control of
the  issuer  of the  securities  and  were  not  acquired  and are  not  held in
connection  with or as a participant in any  transaction  having that purpose or
effect.

<PAGE>
                                    SIGNATURE

                  After  reasonable  inquiry and to the best of my knowledge and
belief,  I certify  that the  information  set forth in this  statement is true,
complete and correct.

Dated:  September 11, 2000



                                             DEUTSCHE BANK AG



                                             By: /s/ Dieter Eisele
                                                --------------------------------
                                                Name:   Dr. Dieter Eisele
                                                Title:  Group Head of Compliance




                                             By: /s/ Christoph Kirschhofer
                                                --------------------------------
                                                Name:   Christoph Kirschhofer
                                                Title:  Director
<PAGE>
                                                                       EXHIBIT 1

                     Consent of Deutsche Funds Holding GmbH


                  The  undersigned  agrees  that the  Schedule  13G  executed by
Deutsche  Bank AG to which this  statement is attached as an exhibit is filed on
behalf of Deutsche Bank AG, Deutsche Funds Holding GmbH and DWS Investment S.A.,
Luxembourg pursuant to Rule 13d-1(k)(1) of the Securities Exchange Act of 1934.

Dated:  September 11, 2000



                                             DEUTSCHE FUNDS HOLDING GMBH



                                             By: /s/ Peter Grafunder
                                                --------------------------------
                                                Name:  Peter Grafunder
                                                Title: Managing Director




                                             By: /s/ Ralf Ring
                                                --------------------------------
                                                Name:  Ralf Ring
                                                Title: Compliance Officer

<PAGE>
                                                                       EXHIBIT 2


                   Consent of DWS Investment S.A., Luxembourg


                  The  undersigned  agrees  that the  Schedule  13G  executed by
Deutsche  Bank AG to which this  statement is attached as an exhibit is filed on
behalf of Deutsche Bank AG, Deutsche Funds Holding GmbH and DWS Investment S.A.,
Luxembourg pursuant to Rule 13d-1(k)(1) of the Securities Exchange Act of 1934.


Dated:  September 11, 2000



                                             DWS INVESTMENT S.A., LUXEMBOURG



                                             By: /s/ Peter Grafunder
                                                --------------------------------
                                                Name:  Peter Grafunder
                                                Title: Managing Director




                                             By: /s/ Ralf Ring
                                                --------------------------------
                                                Name:  Ralf Ring
                                                Title: Compliance Officer



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