LA JOLLA PHARMACEUTICAL CO
SC 13G, 2000-02-24
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G
                              (Amendment No. ___)*

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                         LA JOLLA PHARMACEUTICAL COMPANY
                         -------------------------------
                                (Name of Issuer)
                         -------------------------------

                                  Common Stock
                         -------------------------------
                         (Title of Class of Securities)

                                    503459109
                         -------------------------------
                                 (CUSIP Number)

                                February 17, 2000
         -------------------------------------------------------------
             (Date of Event That Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

         |_|      Rule 13d-1(b)

         |X|      Rule 13d-1(c)

         |_|      Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


<PAGE>

<TABLE>
<CAPTION>

CUSIP No. 503459109                                                                      Page 2 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Alta Partners
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                               (a)
                                                                                        (b)   X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         California
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power            1,470,000
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power                -0-
Person With
                                                     (7)      Sole Dispositive Power       1,470,000

                                                     (8)      Shared Dispositive Power           -0-

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  1,470,000                             Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  6.0%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO
- ------------------------------------------------------------------------------------------------------------------
<FN>
                                       *SEE INSTRUCTION BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
CUSIP No.503459109                                                                       Page 3 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1) Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Alta BioPharma Partners, L.P..
- ------------------------------------------------------------------------------------------------------------------
  (2) Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                        (b)   X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power              913,731
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power                -0-
Person With
                                                     (7)      Sole Dispositive Power         913,731

                                                     (8)      Shared Dispositive Power           -0-

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  913,731                               Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  3.8%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  PN
- ------------------------------------------------------------------------------------------------------------------
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
CUSIP No. 503459109                                                                      Page 4 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Alta BioPharma Management Partners, LLC.
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power              913,731
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power                -0-
Person With
                                                     (7)      Sole Dispositive Power         913,731

                                                     (8)      Shared Dispositive Power           -0-

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  913,731                               Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

         3.8%                       Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO
- ------------------------------------------------------------------------------------------------------------------
</TABLE>



<PAGE>


<TABLE>
<CAPTION>
CUSIP No. 503459109                                                                      Page 5 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         La Jolla Chase Partners (Alta Bio), LLC
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)  X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power              521,828
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power                -0-
Person With
                                                     (7)      Sole Dispositive Power         521,828

                                                     (8)      Shared Dispositive Power           -0-

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  521,828                               Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  2.1%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO
- ------------------------------------------------------------------------------------------------------------------
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  503459109                                                                    Page 6 of 17 pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Alta Embarcadero BioPharma Partners, LLC
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         California
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Powe                34,441
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power                -0-
Person With
                                                     (7)      Sole Dispositive Power          34,441

                                                     (8)      Shared Dispositive Power           -0-

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  34,441                                Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  0.1%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO
- ------------------------------------------------------------------------------------------------------------------
</TABLE>



<PAGE>

<TABLE>
<CAPTION>
CUSIP No.  503459109                                                                    Page 7 of 17 pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Alta/Chase BioPharma Management, LLC
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)  X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         Delaware
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power              521,828
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power                -0-
Person With
                                                     (7)      Sole Dispositive Power         521,828

                                                     (8)      Shared Dispositive Power           -0-

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  521,828                               Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  2.1%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  CO
- ------------------------------------------------------------------------------------------------------------------
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  503459109                                                                     Page 8 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Jean Deleage
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)  X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only

  (4)    Citizenship or Place of Organization

         United States
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power                  -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power          1,470,000
Person With
                                                     (7)      Sole Dispositive Power             -0-

                                                     (8)      Shared Dispositive Power     1,470,000

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  1,470,000                             Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  6.0%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
- ------------------------------------------------------------------------------------------------------------------
<FN>
                                       *SEE INSTRUCTION BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
CUSIP No. 503459109                                                                      Page 9 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Garrett Gruener
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)  X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power                  -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power          1,470,000
Person With
                                                     (7)      Sole Dispositive Power             -0-

                                                     (8)      Shared Dispositive Power     1,470,000

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  1,470,000                             Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  6.0%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
- ------------------------------------------------------------------------------------------------------------------
<FN>
                                       *SEE INSTRUCTION BEFORE FILLING OUT!
</FN>
</TABLE>



<PAGE>


<TABLE>
<CAPTION>
CUSIP No. 503459109                                                                      Page 10 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Daniel Janney
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power                  -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power          1,470,000
Person With
                                                     (7)      Sole Dispositive Power             -0-

                                                     (8)      Shared Dispositive Power     1,470,000

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  1,470,000                             Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  6.0%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
- ------------------------------------------------------------------------------------------------------------------
<FN>
                                       *SEE INSTRUCTION BEFORE FILLING OUT!
</FN>
</TABLE>



<PAGE>

<TABLE>
<CAPTION>
CUSIP No.  503459109                                                                     Page 11 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Alix Marduel
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power                  -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power          1,470,000
Person With
                                                     (7)      Sole Dispositive Power             -0-

                                                     (8)      Shared Dispositive Power     1,470,000

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  1,470,000                             Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  6.0%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
- ------------------------------------------------------------------------------------------------------------------
<FN>
                                       *SEE INSTRUCTION BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
CUSIP No.  503459109                                                             Page 12 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Guy Nohra
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power                  -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power          1,470,000
Person With
                                                     (7)      Sole Dispositive Power             -0-

                                                     (8)      Shared Dispositive Power     1,470,000

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  1,470,000                             Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  6.0%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
- ------------------------------------------------------------------------------------------------------------------
<FN>
                                       *SEE INSTRUCTION BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>


<TABLE>
<CAPTION>
CUSIP No. 503459109                                                                      Page 13 of 17 Pages

- ------------------------------------------------------------------------------------------------------------------
<S>      <C>
  (1)    Names of Reporting Persons.  SS or I.R.S. Identification Nos. of Above Persons

         Marino Polestra
- ------------------------------------------------------------------------------------------------------------------
  (2)    Check The Appropriate Box If A Member Of A Group                                  (a)
                                                                                           (b)   X
- ------------------------------------------------------------------------------------------------------------------
  (3)    SEC Use Only
- ------------------------------------------------------------------------------------------------------------------
  (4)    Citizenship or Place of Organization

         United States
- ------------------------------------------------------------------------------------------------------------------
                                              Please see Attachment A

Number Of Shares                                     (5)      Sole Voting Power                  -0-
Beneficially Owned
By Each Reporting                                    (6)      Shared Voting Power          1,470,000
Person With
                                                     (7)      Sole Dispositive Power             -0-

                                                     (8)      Shared Dispositive Power     1,470,000

  (9)    Aggregate Amount Beneficially Owned By Each Reporting Person

                  1,470,000                             Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (10)   Check If The Aggregate Amount In Row (11) Excludes Certain Shares*

- ------------------------------------------------------------------------------------------------------------------
  (11)   Percent Of Class Represented By Amount In Row (11)

                  6.0%                                  Please see Attachment A
- ------------------------------------------------------------------------------------------------------------------
  (12)   Type Of Reporting Person

                  IN
- ------------------------------------------------------------------------------------------------------------------
<FN>
                                       *SEE INSTRUCTION BEFORE FILLING OUT!
</FN>
</TABLE>


<PAGE>

Item 1.

(a)      Name of Issuer: La Jolla Pharmaceutical Company ("Issuer")

(b)      Address of Issuer's Principal Executive Offices:

                  6455 Nancy Ridge Drive
                  San Diego, CA  92121

Item 2.

(a)      Name of Person Filing:

         Alta Partners ("AP")

         Alta BioPharma Partners, L.P. ("ABP")

         Alta BioPharma Management Partners, LLC. ("ABMP")

         Alta Embarcadero BioPharma Partners, LLC ("AEBP")

         La Jolla Chase Partners (Alta Bio), LLC ("LCP")

         Alta/Chase BioPharma Management, LLC ("ACMP")

         Jean Deleage ("JD")

         Garrett Gruener ("GG")

         Dan Janney ("DJ")

         Alix Marduel ("AM")

         Guy Nohra ("GN")

         Marino Polestra ("MP")


(b)      Address of Principal Business Office:

         One Embarcadero Center, Suite 4050
         San Francisco, CA  94111

(c)      Citizenship/Place of Organization:


         Entities:         AP      -        California
                           ABP     -        Delaware
                           ABMP             Delaware
                           AEBP             California
                           LCP              Delaware
                           ACMP             Delaware

         Individuals:      JD               United States
                           GG               United States
                           DJ               United States
                           AM               United States
                           GN               United States
                           MP               United States

(d)      Title of Class of Securities:      Common Stock

(e)      CUSIP Number:  503459109

(f)      Item 3.  Not applicable.


<PAGE>


<TABLE>

Item 4.        Ownership.

                                                        Please see Attachment A
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
<CAPTION>
                                         AP         ABP         ABMP         AEBP         LCP           ACMP
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
<S>                                  <C>          <C>          <C>          <C>         <C>            <C>
(a)     Beneficial Ownership         1,470,000    913,731      913,731      34,441      521,828        521,828
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(b)     Percentage of Class             6.0%        3.8%        3.8%         0.1%         2.1%          2.1%
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(c)     Sole Voting Power            1,470,000    913,731      913,731      34,441      521,828        521,828
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
        Shared Voting Power             -0-         -0-          -0-         -0-          -0-            -0-
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
        Sole Dispositive Power       1,470,000    913,731      913,731      34,441      521,828        521,828
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
        Shared Dispositive Power        -0-         -0-          -0-         -0-          -0-            -0-
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
                                         JD          GG          DJ           AM           GN            MP
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(a)     Beneficial Ownership         1,470,000   1,470,000    1,470,000   1,470,000    1,470,000      1,470,000
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(b)     Percentage of Class             6.0%        6.0%        6.0%         6.0%         6.0%          6.0%
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
(c)     Sole Voting Power               -0-         -0-          -0-         -0-          -0-            -0-
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
        Shared Voting Power          1,470,000   1,470,000    1,470,000   1,470,000    1,470,000      1,470,000
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
        Sole Dispositive Power          -0-         -0-          -0-         -0-          -0-            -0-
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
        Shared Dispositive Power     1,470,000   1,470,000    1,470,000   1,470,000    1,470,000      1,470,000
- ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
</TABLE>


Item 5.        Ownership of Five Percent or Less of a Class

Not Applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person

Not applicable.

Item 7.        Identification   and   Classification  of  the  Subsidiary  Which
               Acquired the  Security  Being  Reported on By the Parent  Holding
               Company.

Not applicable.

Item 8.        Identification and Classification of Members of the Group

No   reporting   person  is  a  member  of  a  group  as   defined   in  Section
240.13d-1(b)(1)(ii)(H) of the Act.


<PAGE>

Item 9.        Notice of Dissolution of Group

Not applicable.

Item 10.       Certification

By signing below we certify  that, to the best of our knowledge and belief,  the
securities  referred to above were acquired and are held in the ordinary  course
of business  and were not  acquired  and are not held for the purpose of or with
the  effect  of  changing  or  influencing  the  control  of the  issuer  of the
securities  and were not  acquired and are not held in  connection  with or as a
participant in any transaction having that purpose or effect.

EXHIBITS

A:       Joint Filing Statement


<PAGE>



                                    SIGNATURE

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Date:    February 23, 2000


<TABLE>
<CAPTION>

<S>                                                           <C>
ALTA PARTNERS                                                 ALTA BIOPHARMA PARTNERS, L.P.

                                                              By:  Alta BioPharma Management Partners, LLC


By:                                                           By:
   ---------------------------------------------                 -----------------------------------------
             Jean Deleage, President                                  Daniel Janney, Managing Director


ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC                       ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC



By:                                                           By:
   ---------------------------------------------                 -----------------------------------------
              Jean Deleage, Member                                         Daniel Janney, Member


LA JOLLA CHASE PARTNERS (ALTA BIO), LLC                       ALTA/CHASE BIOPHARMA MANAGEMENT, LLC
By: Alta/Chase BioPharma Management, LLC

By:                                                           By:
   ---------------------------------------------                 -----------------------------------------
             Daniel Janney, Member                                         Daniel Janney, Member


   ---------------------------------------------                 -----------------------------------------
                Jean Deleage                                                     Guy Nohra


   ---------------------------------------------                 -----------------------------------------
              Garrett Gruener                                                 Marino Polestra


   ---------------------------------------------                 -----------------------------------------
               Daniel Janney                                                    Alix Marduel

</TABLE>



<PAGE>


                                    EXHIBIT A

                            AGREEMENT OF JOINT FILING

         We, the  undersigned,  hereby  express our agreement  that the attached
Schedule 13G is filed on behalf of us.

Date:    February 23, 2000



<TABLE>
<CAPTION>

<S>                                                           <C>
ALTA PARTNERS                                                 ALTA BIOPHARMA PARTNERS, L.P.

                                                              By:  Alta BioPharma Management Partners, LLC


By:                                                           By:
   ---------------------------------------------                 -----------------------------------------
             Jean Deleage, President                                  Daniel Janney, Managing Director


ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC                       ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC



By:                                                           By:
   ---------------------------------------------                 -----------------------------------------
              Jean Deleage, Member                                         Daniel Janney, Member


LA JOLLA CHASE PARTNERS (ALTA BIO), LLC                       ALTA/CHASE BIOPHARMA MANAGEMENT, LLC
By: Alta/Chase BioPharma Management, LLC

By:                                                           By:
   ---------------------------------------------                 -----------------------------------------
             Daniel Janney, Member                                         Daniel Janney, Member


   ---------------------------------------------                 -----------------------------------------
                Jean Deleage                                                     Guy Nohra


   ---------------------------------------------                 -----------------------------------------
              Garrett Gruener                                                 Marino Polestra


   ---------------------------------------------                 -----------------------------------------
               Daniel Janney                                                    Alix Marduel

</TABLE>


<PAGE>

                                  Attachment A

Alta Partners  provides  investment  advisory  services to three venture capital
funds, Alta BioPharma  Partners L.P., La Jolla Chase Partners  (AltaBio) LLC and
Alta  Embarcadero   BioPharma  Partners,   LLC.  Alta  BioPharma  Partners  L.P.
beneficially  owns  913,731  shares of Common  Stock.  La Jolla  Chase  Partners
(AltaBio) LLC beneficially owns 521,828 shares of Common Stock. Alta Embarcadero
BioPharma  Partners,  LLC  beneficially  owns 34,441 shares of Common Stock. The
respective  general  partners and managing  members of Alta BioPharma  Partners,
L.P.,  La Jolla Chase  Partners  (AltaBio)  LLC and Alta  Embarcadero  BioPharma
Partners,  LLC  exercise  sole voting and  investment  power with respect to the
shares owned by such funds.

The  principals of Alta Partners are members of Alta BioPharma  Management,  LLC
(which is the general partner of Alta BioPharma Partners,  L.P.), and Alta/Chase
BioPharma  Management  LLC  (which  is the  managing  member  of La Jolla  Chase
Partners  (AltaBio),  LLC) and Alta  Embarcadero  BioPharma  Partners,  LLC.  As
general  partners and managing  members of such entities,  they may be deemed to
share  voting  and  investment  powers for the  shares  held by the  funds.  The
principals of Alta  Partners  disclaim  beneficial  ownership of all such shares
held by the  foregoing  funds,  except  to the  extent  of  their  proportionate
pecuniary interests therein.

Alta Partners is a venture capital company with an office in San Francisco. Alta
Partners is California Corporation.  Alta BioPharma Partners, L.P. is a Delaware
Limited  Partnership,  La Jolla  Chase  Partners  (AltaBio),  LLC is a  Delaware
Limited Liability Company,  and Alta Embarcadero  BioPharma  Partners,  LLC is a
California Limited Liability Company.



<PAGE>



                            STOCK PURCHASE AGREEMENT

         This STOCK PURCHASE  AGREEMENT is dated as of the 10th day of February,
2000 by and between La Jolla Pharmaceutical Company, a Delaware corporation with
its  principal  office at 6455 Nancy Ridge  Drive,  San Diego,  California  (the
"Company"),  and  the  several  purchasers  named  in  the  attached  Exhibit  A
(individually, a "Purchaser" and collectively, the "Purchasers").

         WHEREAS,  the Company  desires to issue and sell to the  Purchasers  an
aggregate  of up to  4,400,000  shares  (the  "Shares")  of the  authorized  but
unissued  shares of common stock,  $.01 par value per share, of the Company (the
"Common Stock"); and

         WHEREAS, the Purchasers,  severally, wish to purchase the Shares on the
terms and subject to the conditions set forth in this Agreement.

         NOW   THEREFORE,   in   consideration   of   the   mutual   agreements,
representations,  warranties and covenants herein contained,  the parties hereto
agree as follows:

         1.       Definitions.  As used in this  Agreement,  the following terms
shall have the following respective meanings:

                  (a)  "Affiliate"  of a party  means any  corporation  or other
business  entity  controlled  by,  controlling or under common control with such
party.  For this  purpose  "control"  shall mean direct or  indirect  beneficial
ownership  of fifty  percent  (50%) or more of the voting or income  interest in
such corporation or other business entity.

                  (b) "Closing Date" means the date of the Closing.

                  (c) "Exchange Act" means the Securities  Exchange Act of 1934,
as amended, and all of the rules and regulations promulgated thereunder.

                  (d)  "Registration  Rights  Agreement" shall mean that certain
Registration  Rights Agreement,  dated as of the date hereof,  among the Company
and the Purchasers.

                  (e) "Majority  Purchasers" shall mean Purchasers which, at any
given time,  hold  greater than fifty  percent  (50%) of the voting power of the
outstanding Shares.

                  (f) "SEC" shall mean the Securities and Exchange Commission.

                  (g) "Securities Act" shall mean the Securities Act of 1933, as
amended, and all of the rules and regulations promulgated thereunder.

         2.       Purchase and Sale of Shares.

                  2.1  Purchase  and  Sale.  Subject  to and upon the  terms and
conditions set forth in this Agreement,  the Company agrees to issue and sell to
each Purchaser,  and each Purchaser,  severally,  hereby agrees to purchase from
the  Company,  at the  Closing,  the number of shares of Common  Stock set forth
opposite the name of such  Purchaser  under the heading  "Number of Shares to be
Purchased"  on Exhibit A hereto,  at a purchase  price of $3.375 per share.  The
total  purchase  price  payable  by each  Purchaser  for the number of shares of
Common  Stock that such  Purchaser  is hereby  agreeing to purchase is set forth
opposite  the name of such  Purchaser  under  the  heading  "Purchase  Price" on
Exhibit A hereto.  The aggregate purchase price payable by the Purchasers to the
Company for all of the Shares shall be $13,640,000.

                  2.2  Closing.  The  closing of the  transactions  contemplated
under this Agreement (the "Closing")  shall take place at the offices of Gibson,
Dunn & Crutcher LLP in Irvine,  California on the second  business day after the
Company shall have given written notice to (the "Closing Notice") the Purchasers
that all of


<PAGE>

the conditions precedent set forth in Section 6.1 have been satisfied in full or
at such  other  location,  date  and  time as may be  agreed  upon  between  the
Purchasers  and the Company.  At the Closing,  the Company shall deliver to each
Purchaser a single stock certificate,  registered in the name of such Purchaser,
representing  the number of shares of Common Stock  purchased by such Purchaser,
against  payment of the purchase  price therefor by wire transfer of immediately
available  funds to such account or accounts as the Company  shall  designate in
writing.

         3.       Representations  and  Warranties  of the Company.  The Company
hereby represents and warrants to each of the Purchasers as follows:

                  3.1   Incorporation.   The  Company  is  a  corporation   duly
organized,  validly existing and in good standing under the laws of the State of
Delaware  and is  qualified  to do  business in each  jurisdiction  in which the
character  of  its  properties  or the  nature  of its  business  requires  such
qualification,  except where the failure to so qualify would not have a material
adverse effect upon the Company.  The Company has all requisite  corporate power
and authority to carry on its business as now conducted.

                  3.2  Capitalization.  The  authorized  capital  stock  of  the
Company consists of (i) 100,000,000  shares of Common Stock, of which 20,267,950
shares are  outstanding  as of  February  3, 2000 and (ii)  8,000,000  shares of
preferred  stock, of which no shares are outstanding on the date hereof.  Except
as set forth in Schedule 3.2 hereto,  there are no existing  options,  warrants,
calls,   preemptive  (or  similar)   rights,   subscriptions  or  other  rights,
agreements,  arrangements or commitments of any character obligating the Company
to issue,  transfer or sell,  or cause to be issued,  transferred  or sold,  any
shares of the capital  stock of the  Company or other  equity  interests  in the
Company or any securities  convertible  into or exchangeable  for such shares of
capital  stock  or  other  equity  interests,   and  there  are  no  outstanding
contractual  obligations  of the  Company  to  repurchase,  redeem or  otherwise
acquire any shares of its capital stock or other equity interests.

                  3.3  Authorization.  All  corporate  action on the part of the
Company,   its   officers,   directors  and   stockholders   necessary  for  the
authorization,  execution,  delivery and  performance  of this Agreement and the
Registration   Rights   Agreement  and  the  consummation  of  the  transactions
contemplated  herein and therein has been taken.  When executed and delivered by
the Company,  each of this Agreement and the Registration Rights Agreement shall
constitute the legal, valid and binding  obligation of the Company,  enforceable
against the Company in accordance with its terms,  except as such may be limited
by bankruptcy,  insolvency,  reorganization  or other laws affecting  creditors'
rights  generally  and by general  equitable  principles.  The  Company  has all
requisite  corporate  power to enter into this  Agreement  and the  Registration
Rights Agreement and to carry out and perform its obligations under the terms of
this Agreement, and the Registration Rights Agreement.

                  3.4 Valid Issuance of the Shares.  The Shares being  purchased
by the Purchasers hereunder will, upon issuance pursuant to the terms hereof, be
duly authorized and validly issued, fully paid and nonassessable.

                  3.5  Financial  Statements.  The Company has furnished to each
Purchaser its audited Statements of Income,  Stockholders' Equity and Cash Flows
for the fiscal year ended  December 31, 1998,  its audited  Balance  Sheet as of
December 31, 1998, its unaudited Statements of Income,  Stockholders' Equity and
Cash Flows for the period from December 31, 1998 through September 30, 1999, and
its  unaudited  Balance  Sheet as of  September  30,  1999.  All such  financial
statements  are   hereinafter   referred  to   collectively  as  the  "Financial
Statements".  The Financial  Statements  have been  prepared in accordance  with
generally  accepted  accounting  principles applied on a consistent basis during
the  periods  involved,  and  fairly  present,  in all  material  respects,  the
financial  position of the Company and the results of its  operations  as of the
date and for the periods indicated thereon,  except that the unaudited financial
statements  may  not  be  in  accordance  with  generally  accepted   accounting
principles  because of the absence of footnotes  normally  contained therein and
are subject to normal year-end audit adjustments which, individually, and in the
aggregate,  will not be material.  Since  September  30, 1999,  to the Company's
knowledge,  there has been no material  adverse change (actual or threatened) in
the assets, liabilities (contingent or other), affairs, operations, prospects or
condition (financial or other) of the Company.

                  3.6  SEC   Documents.   The  Company  has  furnished  to  each
Purchaser,  a true and complete copy of the Company's Annual Report on Form 10-K
for the year ended  December 31, 1998,  the Company's  Quarterly  Report on Form
10-Q for the nine months  ended  September  30, 1999,  and any other  statement,
report,  registration statement (other than registration statements on Form S-8)
or  definitive  proxy  statement  filed by the

                                       2
<PAGE>

Company with the SEC during the period commencing  September 30, 1999 and ending
on the date hereof.  The Company will,  promptly upon the filing  thereof,  also
furnish  to  each  Purchaser  all  statements,   reports   (including,   without
limitation,  Quarterly  Reports on Form 10-Q and  Current  Reports on Form 8-K),
registration  statements and definitive  proxy  statements  filed by the Company
with the SEC during the period  commencing  on the date hereof and ending on the
Closing Date (all such  materials  required to be  furnished  to each  Purchaser
pursuant to this  sentence or  pursuant to the next  preceding  sentence of this
Section  3.6  being  called,  collectively,  the "SEC  Documents").  As of their
respective  filing  dates,  the SEC  Documents  complied  or will  comply in all
material  respects with the  requirements  of the Exchange Act or the Securities
Act, as applicable,  and none of the SEC Documents contained or will contain any
untrue  statement of a material fact or omitted or will omit to state a material
fact required to be stated  therein or necessary in order to make the statements
made  therein,  in light of the  circumstances  under which they were made,  not
misleading,  as of their respective filing dates, except to the extent corrected
by a subsequently filed SEC Document.

                  3.7   Consents.   All   consents,    approvals,   orders   and
authorizations  required  on the  part of the  Company  in  connection  with the
execution, delivery or performance of this Agreement and the Registration Rights
Agreement  and the  consummation  of the  transactions  contemplated  herein and
therein have been obtained and will be effective as of the Closing Date.

                  3.8 No Conflict.  The execution and delivery of this Agreement
and the Registration Rights Agreement by the Company and the consummation of the
transactions contemplated hereby and thereby will not conflict with or result in
any violation of or default  (with or without  notice or lapse of time, or both)
under, or give rise to a right of  termination,  cancellation or acceleration of
any obligation or to a loss of a material benefit under (i) any provision of the
Certificate of  Incorporation or By-laws of the Company or (ii) any agreement or
instrument,   permit,  franchise,   license,   judgment,  order,  statute,  law,
ordinance,  rule or  regulations,  applicable  to the Company or its  respective
properties or assets.

                  3.9 Brokers or Finders.  Except for Pacific  Growth  Equities,
Inc., the Company has not dealt with any broker or finder in connection with the
transactions  contemplated by this  Agreement,  and, except for certain fees and
expenses  payable by the Company to Pacific Growth  Equities,  Inc., the Company
has not incurred, and shall not incur, directly or indirectly, any liability for
any brokerage or finders' fees or agents  commissions or any similar  charges in
connection with this Agreement or any transaction contemplated hereby.

                  3.10 Nasdaq National Market. The Common Stock is listed on the
Nasdaq National Market System, and there are no proceedings to revoke or suspend
such listing.

                  3.11  Absence  of  Litigation.  There  is no  action,  suit or
proceeding or, to the Company's knowledge, any investigation, pending, or to the
Company's  knowledge,  threatened by or before any governmental body against the
Company  and in which an  unfavorable  outcome,  ruling or  finding  in any said
matter,  or for all  matters  taken as a whole,  might have a  material  adverse
effect on the Company.  The foregoing  includes,  without  limitation,  any such
action,  suit,  proceeding or investigation that questions this Agreement or the
Registration  Rights  Agreement or the right of the Company to execute,  deliver
and perform under same.

                  3.12 No Bad Acts. The Company represents and warrants that, to
the best of its knowledge,  none of its directors or officers is or has been the
subject of, or a defendant  in: (i) an  enforcement  action or  prosecution  (or
settlement in lieu thereof)  brought by a governmental  authority  relating to a
violation of securities,  fiduciary or criminal laws, or (ii) a civil action (or
settlement in lieu thereof)  brought by  shareholders or investors for violation
of duties owed to the shareholders or investors.

                  3.13  Freedom  to  Operate.  To  the  best  of  the  Company's
knowledge, the conduct by the Company of its businesses, and the manufacture and
sale by the Company of its products,  does not conflict  with,  infringe upon or
violate any patent,  copyright,  trademark,  registration or other  intellectual
property right of any other person or entity.

         4.       Representations   and  Warranties  of  the  Purchasers.   Each
Purchaser  severally  for  itself,  and not jointly  with the other  Purchasers,
represents and warrants to the Company as follows:

                                       3
<PAGE>


                  4.1  Authorization.  All action on the part of such  Purchaser
and, if applicable,  its officers,  directors and shareholders necessary for the
authorization,  execution,  delivery and  performance  of this Agreement and the
Registration   Rights   Agreement  and  the  consummation  of  the  transactions
contemplated  herein and therein has been taken.  When  executed and  delivered,
each of this Agreement and the Registration Rights Agreement will constitute the
legal, valid and binding obligation of such Purchaser,  enforceable against such
Purchaser  in  accordance  with its  terms,  except  as such may be  limited  by
bankruptcy, insolvency, reorganization or other laws affecting creditors' rights
generally and by general equitable principles.  Such Purchaser has all requisite
corporate power to enter into each of this Agreement and the Registration Rights
Agreement and to carry out and perform its  obligations  under the terms of this
Agreement and the Registration Rights Agreement.

                  4.2  Purchase  Entirely  for Own  Account.  Such  Purchaser is
acquiring the Shares being purchased by it hereunder for investment, for its own
account,  and not for resale or with a view to distribution thereof in violation
of the Securities Act.

                  4.3  Investor  Status;   Etc.  Such  Purchaser  certifies  and
represents  to the Company that at the time such  Purchaser  acquires any of the
Shares,  such Purchaser will be an "Accredited  Investor" as defined in Rule 501
of Regulation D promulgated  under the  Securities Act and was not organized for
the purpose of acquiring the Shares.  Such  Purchaser's  financial  condition is
such that it is able to bear the risk of holding  the  Shares for an  indefinite
period of time and the risk of loss of its entire investment. Such Purchaser has
been afforded the  opportunity to ask questions of and receive  answers from the
management  of  the  Company  concerning  this  investment  and  has  sufficient
knowledge  and  experience  in investing in companies  similar to the Company in
terms of the  Company's  stage of  development  so as to be able to evaluate the
risks and merits of its investment in the Company.

                  4.4 Shares Not Registered. Such Purchaser understands that the
Shares have not been  registered  under the  Securities  Act, by reason of their
issuance  by  the  Company  in  a  transaction   exempt  from  the  registration
requirements of the Securities Act, and that the Shares must continue to be held
by such Purchaser  unless a subsequent  disposition  thereof is registered under
the  Securities  Act  or  is  exempt  from  such  registration.   The  Purchaser
understands  that the  exemptions  from  registration  afforded by Rule 144 (the
provisions of which are known to it) promulgated under the Securities Act depend
on the satisfaction of various conditions, and that, if applicable, Rule 144 may
afford the basis for sales only in limited amounts.

                  4.5 No Conflict.  The execution and delivery of this Agreement
and the Registration  Rights Agreement by such Purchaser and the consummation of
the  transactions  contemplated  hereby and thereby  will not  conflict  with or
result in any violation of or default by such Purchaser  (with or without notice
or lapse  of  time,  or both)  under,  or give  rise to a right of  termination,
cancellation  or  acceleration  of any  obligation  or to a loss  of a  material
benefit  under  (i)  any  provision  of the  organizational  documents  of  such
Purchaser  or (ii) any  agreement or  instrument,  permit,  franchise,  license,
judgment,  order,  statute, law, ordinance,  rule or regulations,  applicable to
such Purchaser or its respective properties or assets.

                  4.6 Brokers. Such Purchaser has not retained, utilized or been
represented  by any  broker  or  finder  in  connection  with  the  transactions
contemplated by this Agreement.

                  4.7   Consents.   All   consents,    approvals,   orders   and
authorizations  required on the part of such  Purchaser in  connection  with the
execution, delivery or performance of this Agreement and the consummation of the
transactions  contemplated herein have been obtained and are effective as of the
Closing Date.

         5.       Conditions Precedent.

                  5.1.  Conditions  to  the  Obligation  of  the  Purchasers  to
Consummate  the Closing.  The  obligation of each  Purchaser to  consummate  the
Closing and to purchase and pay for the Shares being purchased by it pursuant to
this  Agreement  is  subject to the  satisfaction  of the  following  conditions
precedent:

                  (a) The representations and warranties contained herein of the
Company  shall be true and correct on and as of the  Closing  Date with the same
force  and  effect  as  though  made on and as of the  Closing  Date  (it  being
understood and agreed by each Purchaser that, in the case of any  representation
and warranty of the



                                       4
<PAGE>

Company  contained  herein which is not  hereinabove  qualified  by  application
thereto of a materiality standard, such representation and warranty need be true
and  correct  only in all  material  respects  in  order to  satisfy  as to such
representation  or warranty the  condition  precedent set forth in the foregoing
provisions of this Section 5.1(a)).

                  (b) The Registration Rights Agreement shall have been executed
and delivered by the Company.

                  (c) The Company shall not have been adversely  affected in any
material way prior to the Closing Date; and the Company shall have performed all
obligations  and conditions  herein  required to be performed or observed by the
Company on or prior to the Closing Date.

                  (d)  No   proceeding   challenging   this   Agreement  or  the
transactions  contemplated  hereby,  or seeking to prohibit,  alter,  prevent or
materially  delay the  Closing,  shall  have been  instituted  before any court,
arbitrator or governmental body, agency or official and shall be pending.

                  (e)  The  purchase  of  and  payment  for  the  Shares  by the
Purchasers  shall  not  be  prohibited  by  any  law or  governmental  order  or
regulation.  All necessary consents,  approvals,  licenses,  permits, orders and
authorizations  of,  or  registrations,   declarations  and  filings  with,  any
governmental or administrative agency or of any other person with respect to any
of the  transactions  contemplated  hereby shall have been duly obtained or made
and shall be in full force and effect.

                  (f) All  instruments  and corporate  proceedings in connection
with the  transactions  contemplated  by this Agreement to be consummated at the
Closing shall be satisfactory in form and substance to such Purchaser,  and such
Purchaser  shall  have  received  copies  (executed  or  certified,  as  may  be
appropriate) of all documents which such Purchaser may have reasonably requested
in connection with such transactions.

                  5.2. Conditions to the Obligation of the Company to Consummate
the Closing.  The  obligation  of the Company to  consummate  the Closing and to
issue and sell to each of the Purchasers the Shares to be purchased by it at the
Closing is subject to the satisfaction of the following conditions precedent:

                  (a) The  representations  and warranties  contained  herein of
such Purchaser  shall be true and correct on and as of the Closing Date with the
same force and  effect as though  made on and as of the  Closing  Date (it being
understood and agreed by the Company that, in the case of any representation and
warranty of each Purchaser  contained herein which is not hereinabove  qualified
by  application  thereto of a  materiality  standard,  such  representation  and
warranty  need be true and  correct  only in all  material  respects in order to
satisfy as to such  representation or warranty the condition precedent set forth
in the foregoing provisions of this Section 5.2(a)).

                  (b) The Registration Rights Agreement shall have been executed
and delivered by each Purchaser.

                  (c) The Purchasers  shall have performed all  obligations  and
conditions  herein  required to be performed or observed by the Purchasers on or
prior to the Closing Date.

                  (d)  No   proceeding   challenging   this   Agreement  or  the
transactions  contemplated  hereby,  or seeking to prohibit,  alter,  prevent or
materially  delay the  Closing,  shall  have been  instituted  before any court,
arbitrator or governmental body, agency or official and shall be pending.

                  (e)  The  sale  of the  Shares  by the  Company  shall  not be
prohibited  by any  law or  governmental  order  or  regulation.  All  necessary
consents,  approvals,  licenses,  permits,  orders  and  authorizations  of,  or
registrations, declarations and filings with, any governmental or administrative
agency  or of  any  other  person  with  respect  to  any  of  the  transactions
contemplated  hereby shall have been duly  obtained or made and shall be in full
force and effect.

                  (f) Each of the  Purchasers  shall have executed and delivered
to the  Company a  Purchaser's  Questionnaire,  in the form  attached  hereto as
Exhibit B,  pursuant  to which each such  Purchaser  shall  provide

                                       5
<PAGE>

information  necessary to confirm each such Purchaser's status as an "accredited
investor" (as such term is defined in Rule 501 promulgated  under the Securities
Act)".

                  (g) Each of the other  Purchasers  shall  have  purchased,  in
accordance with this  Agreement,  the number of shares of Common Stock set forth
opposite its name under the heading "Number of Shares to be Purchased".

                  (h) All  instruments  and corporate  proceedings in connection
with the  transactions  contemplated  by this Agreement to be consummated at the
Closing  shall be  satisfactory  in form and  substance to the Company,  and the
Company shall have received counterpart originals,  or certified or other copies
of all documents,  including  without  limitation  records of corporate or other
proceedings, which it may have reasonably requested in connection therewith.

         6.       Transfer, Legends.

                  6.1. Securities Law Transfer Restrictions.  No Purchaser shall
sell,  assign,  pledge,  transfer or  otherwise  dispose or encumber  any of the
Shares  being  purchased  by it  hereunder,  except (i) pursuant to an effective
registration statement under the Securities Act or (ii) pursuant to an available
exemption  from  registration  under the  Securities  Act and  applicable  state
securities  laws  and,  if  requested  by the  Company,  upon  delivery  by such
Purchaser of an opinion of counsel reasonably satisfactory to the Company to the
effect  that the  proposed  transfer  is  exempt  from  registration  under  the
Securities Act and applicable  state  securities laws. Any transfer or purported
transfer of the Shares in violation of this Section 6.1 shall be voidable by the
Company.  The Company shall not register any transfer of the Shares in violation
of this Section  6.1.  The Company may, and may instruct any transfer  agent for
the  Company,  to place  such stop  transfer  orders as may be  required  on the
transfer books of the Company in order to ensure  compliance with the provisions
of this Section 6.1.

                  6.2.  Legends.  Each certificate  requesting any of the Shares
shall be endorsed with the legends set forth below, and each Purchaser covenants
that, except to the extent such restrictions are waived by the Company, it shall
not transfer the shares  represented by any such certificate  without  complying
with the  restrictions  on transfer  described in this Agreement and the legends
endorsed on such certificate:

         "THE SHARES  REPRESENTED BY THIS  CERTIFICATE  HAVE NOT BEEN REGISTERED
         UNDER  THE  SECURITIES  ACT OF  1933  AND  MAY  NOT BE  OFFERED,  SOLD,
         ASSIGNED,  PLEDGED  TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE
         OF AN EFFECTIVE REGISTRATION STATEMENT UNDER SAID ACT OR PURSUANT TO AN
         AVAILABLE  EXEMPTION FROM REGISTRATION UNDER SAID ACT AND, IF REQUESTED
         BY THE  COMPANY,  UPON  DELIVERY  OF AN OPINION  OF COUNSEL  REASONABLY
         SATISFACTORY  TO THE COMPANY THAT THE PROPOSED  TRANSFER IS EXEMPT FROM
         SAID ACT."

         7.       Termination;  Liabilities  Consequent Thereon.  This Agreement
may be terminated and the transactions  contemplated  hereunder abandoned at any
time prior to the Closing only as follows:

                  (a) by the  Purchasers,  upon  notice  to the  Company  if the
conditions set forth in Section 5.1 shall not have been satisfied on or prior to
February 16, 2000; or

                  (b) by the  Company,  upon  notice  to the  Purchasers  if the
conditions set forth in Section 5.2 shall not have been satisfied on or prior to
February 16, 2000; or

                  (c) at any time by mutual  agreement  of the  Company  and the
Purchasers; or

                  (d) by the  Purchasers,  if there  has been any  breach of any
representation or warranty or any material breach of any covenant of the Company
contained  herein  and the same has not been cured  within 15 days after  notice
thereof,  (it being understood and agreed by each Purchaser that, in the case of
any  representation  or warranty of the Company  contained  herein  which is not
hereinabove  qualified by application  thereto of a materiality  standard,  such
representation  or warranty will be deemed to have been breached for


                                       6
<PAGE>

purposes of this Section 7.1(d) only if such  representation or warranty was not
true and correct in all  material  respects at the time such  representation  or
warranty was made by the Company); or

                  (e) by the  Company,  if  there  has been  any  breach  of any
representation, warranty or any material breach of any covenant of any Purchaser
contained  herein  and the same has not been cured  within 15 days after  notice
thereof (it being  understood and agreed by the Company that, in the case of any
representation  and  warranty of the  Purchaser  contained  herein  which is not
hereinabove  qualified by application  thereto of a materiality  standard,  such
representation  or warranty will be deemed to have been breached for purposes of
this  Section  7.1(e) only if such  representation  or warranty was not true and
correct in all material respects at the time such representation or warranty was
made by such Purchaser).

         Any termination  pursuant to this Section 7 shall be without  liability
on the part of any party,  unless such  termination  is the result of a material
breach  of this  Agreement  by a party  to this  Agreement  in which  case  such
breaching  party  shall  remain  liable  for  such  breach  notwithstanding  any
termination of this Agreement.

         8.       Miscellaneous Provisions.

                  8.1 Public Statements or Releases. None of the parties to this
Agreement shall make, issue, or release any announcement,  whether to the public
generally,  or to any of its  suppliers  or  customers,  with  respect  to  this
Agreement  or the  transactions  provided for herein,  or make any  statement or
acknowledgment  of the existence of, or reveal the status of, this  Agreement or
the  transactions  provided for herein,  without the prior  consent of the other
parties,  which shall not be unreasonably  withheld or delayed,  provided,  that
nothing in this Section 8.1 shall prevent any of the parties  hereto from making
such public  announcements as it may consider  necessary in order to satisfy its
legal obligations,  but to the extent not inconsistent with such obligations, it
shall provide the other parties with an opportunity to review and comment on any
proposed public announcement before it is made.

                  8.2 Further  Assurances.  Each party agrees to cooperate fully
with the other party and to execute  such  further  instruments,  documents  and
agreements  and to give such further  written  assurances,  as may be reasonably
requested  by the other party to better  evidence  and reflect the  transactions
described herein and contemplated  hereby,  and to carry into effect the intents
and purposes of this Agreement.

                  8.3 Notification of  Effectiveness of Registration  Statement.
The  Company  covenants  that it will  provide  written  notice to SWIB that the
Company's  registration  statement  on Form  S-3  registering  the  shares  sold
hereunder to SWIB has been  declared  effective by the SEC.  This notice will be
sent to SWIB no later than 48 hours after such declaration by the SEC.

                  8.4 Rights  Cumulative.  Each and all of the  various  rights,
powers and remedies of the parties shall be considered to be cumulative with and
in addition to any other rights, powers and remedies which such parties may have
at law or in  equity  in the  event of the  breach  of any of the  terms of this
Agreement.  The exercise or partial exercise of any right, power or remedy shall
neither  constitute the exclusive  election  thereof nor the waiver of any other
right, power or remedy available to such party.

                  8.5 Pronouns.  All pronouns or any variation  thereof shall be
deemed to refer to the masculine, feminine or neuter, singular or plural, as the
identity of the person, persons, entity or entities may require.

                  8.6      Notices.

                  (a) Any notices, reports or other correspondence  (hereinafter
collectively referred to as "correspondence")  required or permitted to be given
hereunder shall be sent by postage prepaid first class mail, courier or telecopy
or  delivered  by hand to the party to whom such  correspondence  is required or
permitted to be given hereunder. The date of giving any notice shall be the date
of its actual receipt.

                  (b) All  correspondence  to the Company  shall be addressed as
follows:

                           La Jolla Pharmaceutical Company
                           6455 Nancy Ridge Drive


                                       7
<PAGE>

                           San Diego, California  92121
                           Attention: Steven B. Engle
                           Telecopier: (858) 452-6893

                  with a copy to:

                           Gibson, Dunn & Crutcher LLP
                           4 Park Plaza
                           Irvine, California 92614
                           Attention:  Leonard J. McGill
                           Telecopier: (949) 451-4220

                  (c) All  correspondence to any Purchaser shall be sent to such
Purchaser at the address set forth in Exhibit A.

                  (d) Any entity may change the address to which  correspondence
to it is to be addressed by notification as provided for herein.

                  8.7  Captions.  The  captions and  paragraph  headings of this
Agreement are solely for the  convenience  of reference and shall not affect its
interpretation.

                  8.8  Severability.  Should  any  part  or  provision  of  this
Agreement  be held  unenforceable  or in conflict  with the  applicable  laws or
regulations of any jurisdiction, the invalid or unenforceable part or provisions
shall be replaced with a provision which  accomplishes,  to the extent possible,
the  original  business  purpose  of such  part  or  provision  in a  valid  and
enforceable  manner,  and the remainder of this  Agreement  shall remain binding
upon the parties hereto.

                  8.9      Governing Law; Injunctive Relief.

                  (a) This  Agreement  shall be  governed  by and  construed  in
accordance with the internal and substantive laws of the State of California and
without  regard  to  any  conflicts  of  laws  concepts  that  would  apply  the
substantive law of some other jurisdiction.

                  (b) Each of the parties  hereto  acknowledges  and agrees that
damages will not be an adequate  remedy for any material  breach or violation of
this Agreement if such material  breach or violation  would cause  immediate and
irreparable  harm (an  "Irreparable  Breach").  Accordingly,  in the  event of a
threatened or ongoing Irreparable Breach, each party hereto shall be entitled to
seek, in any state or federal court in the State of California, equitable relief
of a kind  appropriate  in light of the  nature  of the  ongoing  or  threatened
Irreparable  Breach,  which relief may  include,  without  limitation,  specific
performance or injunctive relief; provided,  however, that if the party bringing
such action is  unsuccessful  in obtaining the relief  sought,  the moving party
shall pay the non-moving  party's reasonable costs,  including  attorney's fees,
incurred in connection  with defending  such action.  Such remedies shall not be
the parties' exclusive remedies,  but shall be in addition to all other remedies
provided in this Agreement.

                  8.10 Waiver. No waiver of any term,  provision or condition of
this Agreement,  whether by conduct or otherwise,  in any one or more instances,
shall be deemed to be, or be construed as, a further or continuing waiver of any
such term, provision or condition or as a waiver of any other term, provision or
condition of this Agreement.

                  8.11 Expenses. Each party will bear its own costs and expenses
in connection with this Agreement.

                  8.12  Assignment.  The rights and  obligations  of the parties
hereto  shall inure to the benefit of and shall be binding  upon the  authorized
successors  and  permitted  assigns of each party.  Neither party may assign its
rights or obligations  under this  Agreement or designate  another person (i) to
perform all or part of its obligations  under this Agreement or (ii) to have all
or part of its rights and benefits  under this  Agreement,  in each case without
the prior written  consent of the other party. In the event of any assignment in
accordance  with the terms of this

                                       8
<PAGE>

Agreement, the assignee shall specifically assume and be bound by the provisions
of the Agreement by executing and agreeing to an assumption agreement reasonably
acceptable to the other party.

                  8.13 Survival.  The respective  representations and warranties
given by the parties hereto,  and the other  covenants and agreements  contained
herein,  shall survive the Closing Date and the consummation of the transactions
contemplated  herein  for  a  period  of  two  years,   without  regard  to  any
investigation made by any party.

                  8.14 Entire Agreement.  This Agreement  constitutes the entire
agreement  between the parties  hereto  respecting the subject matter hereof and
supersedes all prior agreements, negotiations,  understandings,  representations
and statements respecting the subject matter hereof, whether written or oral. No
modification, alteration, waiver or change in any of the terms of this Agreement
shall be valid or binding  upon the  parties  hereto  unless made in writing and
duly executed by the Company and the Majority Purchasers.


                                       9
<PAGE>


         IN  WITNESS  WHEREOF,  the  parties  hereto  have  executed  this Stock
Purchase Agreement under seal as of the day and year first above written.



                                             LA JOLLA PHARMACEUTICAL COMPANY


                                             By: -------------------------------
                                             Name:
                                             Title:



THE PURCHASER'S SIGNATURE TO THE INVESTOR QUESTIONNAIRE DATED EVEN DATE HEREWITH
SHALL CONSTITUTE THE PURCHASER'S SIGNATURE TO THIS STOCK PURCHASE AGREEMENT.


<PAGE>


<TABLE>
                                              Exhibit A

- ----------------------------------------------------------------------------- ----------------------------
<CAPTION>
Purchaser                                                                               Number of Shares
- ----------------------------------------------------------------------------- ----------------------------
<S>                                                                                          <C>
Alta Embarcadero BioPharma, LLC                                                              34,441
One Embarcadero Center
Suite 4050
San Francisco, CA  94111
- ----------------------------------------------------------------------------- ----------------------------
Alta BioPharma Partners, LP                                                                 913,731
One Embarcadero Center
Suite 4050
San Francisco, CA  94111
- ----------------------------------------------------------------------------- ----------------------------
La Jolla Chase Partners (Alta Bio), LLC                                                     521,828
One Embarcadero Center
Suite 4050
San Francisco, CA  94111
- ----------------------------------------------------------------------------- ----------------------------
Deutsche Asset Management                                                                   100,000
(Dirfonds - AP)
Investmentgesellschaft MBH
Mainzer Landstrasse 16
Postfach 20-01-11 60605 Frankfurt
- ----------------------------------------------------------------------------- ----------------------------
Deutsche Vermogesbildungsgesellschaft mbH                                                   450,000
Attn:  D. Endrikat
Feldbergstrasse 22
60323 Frankfurt, Germany
- ----------------------------------------------------------------------------- ----------------------------
Deutsche Asset Management                                                                   450,000
(NAVAP)
Investmentgesellschaft MBH
Mainzer Landstrasse 16
Postfach 20-01-11 60605 Frankfurt, Germany
- ----------------------------------------------------------------------------- ----------------------------
Special Situations Private Equity Fund, LP                                                  300,000
153 E. 53rd Street
New York, NY  10022
- ----------------------------------------------------------------------------- ----------------------------
Special Situations Cayman Fund, LP                                                          100,000
153 E. 53rd Street
New York, NY  10022
- ----------------------------------------------------------------------------- ----------------------------
Special Situations Fund III, LP                                                             275,000
153 E. 53rd Street
New York, NY  10022
- ----------------------------------------------------------------------------- ----------------------------
State of Wisconsin Investment Board                                                         880,000
121 E. Wilson Street
Madison, WI  53707-7842
- ----------------------------------------------------------------------------- ----------------------------
ChaseEquity Associates LLC                                                                   15,000
380 Madison Avenue, 12th Floor
New York, NY  10017
- ----------------------------------------------------------------------------- ----------------------------
</TABLE>


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