TRIPOS INC
DEF 14A, 1997-04-10
PREPACKAGED SOFTWARE
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                           (Company logo)
                            TRIPOS, INC.
                                  
                                  
              NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                       To Be Held May 9, 1997
                                  
To Our Shareholders:

      The  Annual  Meeting  of Shareholders  of  Tripos,  Inc.  (the
"Company") will be held at the World Trade Center St. Louis, 121  S.
Meramec,  10th  Floor, Clayton, Missouri, 63105 at 1:00  p.m.  local
time on May 9, 1997 for the following purposes:

      1.   To elect directors to serve for the ensuing year or until
their successors are elected;

     2.   To amend the 1994 Stock Option Plan to increase the number
of shares reserved thereunder from 704,000 to 1,100,000 shares;

     3.   To act upon such other business as may properly come before the
Annual Meeting or at any adjournments or postponements thereof.


     The Board of Directors has fixed the close of business on April 4,
1997  as the record date for determining those shareholders  who
will be entitled to notice of and to vote at the Annual Meeting.

     Representation of at least a majority of all outstanding shares
of  Common Stock of the Company is required to constitute a  quorum.
Accordingly, it is important that your shares be represented at  the
meeting.   WHETHER  OR  NOT YOU PLAN TO ATTEND THE  ANNUAL  MEETING,
PLEASE COMPLETE, DATE AND SIGN THE ENCLOSED PROXY FORM AND RETURN IT
IN  THE  ENCLOSED ENVELOPE.  You may revoke your proxy at  any  time
prior to the time it is voted.  If you attend the Annual Meeting and
vote  by  ballot, your proxy will be revoked automatically and  only
your vote at the Annual Meeting will be counted.

                                             Sincerely,



                                             Colleen A. Martin
                                             Corporate Secretary

St. Louis, Missouri
April 9, 1997
                                  
         Shareholders Should Read the Entire Proxy Statement
           Carefully Prior to Returning Their Proxy Forms
                                  
                           PROXY STATEMENT
                                 FOR
                  ANNUAL MEETING OF SHAREHOLDERS OF
                            TRIPOS, INC.
                                  
                       To Be Held May 9, 1997
                                  
      This  Proxy  Statement  is furnished in  connection  with  the
solicitation by the Board of Directors of Tripos, Inc. ("Tripos"  or
the  "Company")  of  proxies to be voted at the  Annual  Meeting  of
Shareholders which will be held at 1:00 p.m. local time  on  May  9,
1997  at  the  World Trade Center St. Louis, 121  S.  Meramec,  10th
Floor,   Clayton,   Missouri  63105,  or  at  any  adjournments   or
postponements   thereof,  for  the  purposes  set   forth   in   the
accompanying Notice of Annual Meeting of Shareholders.   This  Proxy
Statement and the accompanying proxy form are first being mailed  to
shareholders on or about April 9, 1997.

                   VOTING RIGHTS AND SOLICITATION
                                  
      The close of business on April 4, 1997 was the record date for
shareholders  entitled  to  notice of and  to  vote  at  the  Annual
Meeting.   As  of that date, Tripos had 3,049,175 shares  of  Common
Stock,  $.01  par value per share (the "Common Stock"),  issued  and
outstanding.   All  of  the  shares of the  Company's  Common  Stock
outstanding  on the record date are entitled to vote at  the  Annual
Meeting, and shareholders of record entitled to vote at the  meeting
will  have one (1) vote for each share so held on the matters to  be
voted upon.

      Shares of the Company's Common Stock represented by proxies in
the  accompanying form that are properly executed  and  returned  to
Tripos  will  be  voted  at the Annual Meeting  of  Shareholders  in
accordance  with  the shareholders' instructions contained  therein.
In  the absence of contrary instructions, shares represented by such
proxies  will be voted FOR the election of each of the directors  as
described herein under "Proposal 1 -- Election of Directors" and FOR
the  amendment  to  the 1994 Stock Option Plan as  described  herein
under  "Proposal  2  -- Amendment to the 1994  Stock  Option  Plan".
Management  does  not know of any matters to be  presented  in  this
Annual  Meeting  other than those set forth in this Proxy  Statement
and  in  the  Notice  accompanying this Proxy Statement.   If  other
matters  should properly come before the meeting, the proxy  holders
will  vote  on such matters in accordance with their best  judgment.
Any shareholder has the right to revoke his or her proxy at any time
before  it is voted.  A majority of the outstanding shares of Common
Stock,  present in person or by proxy, will constitute a quorum  for
the  transaction of business at the Annual Meeting.  The affirmative
vote of a plurality of the shares present, in person or by proxy, at
the  Annual  Meeting,  is required to elect directors.   "Plurality"
means that the nominees who receive the largest number of votes cast
are elected as directors up to the maximum number of directors to be
elected at the Annual Meeting.  Consequently, any shares represented
at  the  Annual Meeting but not voted for any reason, have no impact
on  the  election of directors.  The affirmative vote of the holders
of  a majority of the shares which are present in person or by proxy
at  the Annual Meeting is required to approve Proposal 2 and to  act
on  any  other matters properly brought before this meeting.  Shares
represented  by  proxies which are marked "withhold authority"  with
respect  to  the  election of any one or more of  the  nominees  for
election of directors will be counted for the purpose of determining
the  number  of  shares represented by proxy at the  meeting.   Such
proxies  will thus have the same effect as if the shares represented
thereby  were  voted  against  such  nominee  or  nominees.   If  no
specification  is made on a duly executed proxy, the proxy  will  be
voted  FOR  election  of the directors nominated  by  the  Board  of
Directors and FOR Proposal 2.  Abstentions and broker non-votes  are
each  included in the determination of the number of shares  present
for  quorum purposes.  Abstentions are counted in tabulations of the
votes  cast  on proposals presented to shareholders, whereas  broker
non-votes  are  not  counted for purposes of determining  whether  a
proposal has been approved.

      The entire cost of soliciting proxies will be borne by Tripos.
Proxies will be solicited principally through the use of the  mails,
but,  if  deemed  desirable,  may  be  solicited  personally  or  by
telephone, telefax or special letter by officers and regular  Tripos
employees for no additional compensation.  The Board of Directors of
the  Company has engaged Boatmen's Trust Company to provide  routine
advice  and  services and D.F. King & Co., Inc.  to  assist  in  the
solicitation  proxies for an estimated fee of $5,000 plus  expenses.
Arrangements  have  been  made  with  brokerage  houses  and   other
custodians,  nominees  and fiduciaries to  send  proxies  and  proxy
materials  to  the beneficial owners of the Company's Common  Stock,
and such persons shall be reimbursed for their reasonable expenses.

                        SHAREHOLDER PROPOSALS
                                  
      Shareholder proposals intended to be considered  at  the  1998
Annual  Meeting of Shareholders must be received by Tripos no  later
than December 5, 1997.  The proposal must be mailed to the Company's
principal  executive  offices, 1699 South Hanley  Road,  St.  Louis,
Missouri  63144, Attention: Corporate Secretary.  Such proposals may
be  included  in  next year's proxy statement if  they  comply  with
certain  rules  and  regulations promulgated by the  Securities  and
Exchange Commission.



             MATTERS TO BE CONSIDERED AT ANNUAL MEETING
                                  
                             PROPOSAL 1:
                                  
                        ELECTION OF DIRECTORS

      The  nominees for the Board of Directors are set forth  below.
The proxy holders intend to vote all proxies received by them in the
accompanying form for the nominees for directors listed  below.   In
the  event any nominee is unable or declines to serve as a  director
at the time of the Annual Meeting, either the size of the Board will
be reduced or the proxies will be voted for any nominee who shall be
designated  by the present Board of Directors to fill  the  vacancy.
In  the event that additional persons are nominated for election  as
directors, the proxy holders intend to vote all proxies received  by
them  for  the nominees listed below.  As of the date of this  Proxy
Statement, the Board of Directors is not aware of any nominee who is
unable  or will decline to serve as a director.  The directors  will
serve for a one year term, or until their respective successors  are
duly elected and qualified.  Directors are elected by a plurality of
the votes present in person or represented by proxy and entitled  to
vote at the meeting.

Nominees to Board of Directors
    Name               Director    Age       Name            Director    Age
                        Since                                  Since      
                                                              
  Ralph S. Lobdell      1994      53    Alfred Alberts          1997      65
  Stewart Carrell       1994      63    John P. McAlister,III   1994      48
  Gary Meredith         1996      62    Ferid Murad             1996      60

     Ralph  S.  Lobdell  has  served as Chairman  of  the  Board  of
Directors of the Company since June 1994.  Mr. Lobdell received  his
Bachelor  of Science degree from the U.S. Naval Academy in 1965  and
his  Master  of Business Administration from Stanford University  in
1972.   Mr.  Lobdell worked for First Chicago Corporation from  1972
through  1977, initially on the parent company staff  and  then  its
venture  capital subsidiaries.  In 1977, Mr. Lobdell  joined  Abbott
Laboratories  in  Chicago  as  Manager  of  Corporate  Planning  and
Development.  Mr. Lobdell worked for the Harbour Group, a St.  Louis
based  investment  company,  from 1979 to  1991  and  was  appointed
President in 1987.  He served on the Board of Directors of virtually
all of Harbour's portfolio companies acquired during his tenure.

      Alfred Alberts was named a Director of the Company in February
1997.  Mr. Alberts is currently serving on the Board of Directors of
Inflazyme  Pharmaceuticals, Ltd., Vancouver,  and  is  a  scientific
consultant to several major pharmaceutical companies.  He served  as
the Vice President of Biochemistry and Natural Product Discovery  at
Merck  Research Laboratories prior to his retirement in 1995.  Prior
to  joining  Merck, Mr. Alberts was a member of the faculty  of  the
Department of Biochemistry at Washington University, St. Louis.  Mr.
Alberts has co-authored six patents and received several prestigious
awards including the Thomas Alva Edison Award as well as an Honorary
Doctor of Science degree from the University of Maryland.

      Stewart  Carrell has been a Director of the Company since  May
1994.  He currently serves as Chairman of the Board of Directors  of
Evans & Sutherland Computer Corporation.  Until October 1993, he was
Chairman  and Chief Executive Officer of Diasonics, Inc., a  medical
imaging  company.  From November 1983 to 1987, he was also a General
Partner  of  Hambrecht & Quist, an investment  banking  and  venture
capital firm.  Prior to November 1983, Mr. Carrell was employed  for
25 years by Texas Instruments in various capacities, the most recent
of  which was Executive Vice President.  Mr. Carrell also serves  as
Chairman of Seattle Silicon Corporation.

      Dr.  John  P.  McAlister, III has served  as  Chief  Executive
Officer  and  Director since May 1994.  Dr. McAlister  obtained  his
B.S.  in Chemistry from Tarleton State College in 1971 and his Ph.D.
in  Biochemistry  and X-Ray Crystallography from the  University  of
Wisconsin,   Madison,  in  1978.   After  a  two-year  post-doctoral
appointment, Dr. McAlister joined the staff of the Computer  Systems
Laboratory  at Washington University, St. Louis, in 1980,  where  he
served   first   as  Associate  Director  of  the   MMS-X   National
Collaborative  Research Program and then as  Research  Associate  in
Computer  Science.  Dr. McAlister began working for Tripos  in  1982
under  contract  to  supervise software  development  for  molecular
graphics  applications.  In 1984, he joined Tripos  as  Director  of
Software Research and Development.  In 1987, Dr. McAlister was named
Vice  President, Research and Development, and in 1988 was  promoted
to President.

      Gary  Meredith  was appointed a Director  of  the  Company  in
January  1996.   He  currently serves as Senior Vice  President  and
Secretary  of Evans & Sutherland Computer Corporation ("E&S").   Mr.
Meredith  has  been with E&S for nineteen years where  he  has  held
several   positions  including  Assistant  to  the  President,   VP-
Administration,   President-Interactive   Systems   Division,    VP-
Development, and Chief Financial Officer.  Prior to joining E&S,  he
was   President  of   Interwest  General  Corporation  and   Windsor
Industries.  Mr. Meredith also was Chairman and President  of  Reid-
Meredith, Inc., a company he founded in 1962.  Mr. Meredith received
his  B.S. degree from Brigham Young University.  In addition to  his
position  on  the Board of Directors of Tripos, Mr.  Meredith  is  a
Director of Blue Cross/Blue Shield of Utah and Strata, Inc.

      Dr.  Ferid  Murad was appointed a Director of the  Company  in
November  1996.  Dr. Murad received his M.D. and Ph.D. from  Western
Reserve  University.   Dr.  Murad is the former  Vice  President  of
Pharmaceutical Research and Development at Abbott Laboratories,  and
formerly, the President and CEO of Molecular Geriatrics Corporation,
a  bio-pharmaceutical  company.  Dr. Murad  has  held  a  number  of
notable  positions  during  his career  including  Chairman  of  the
Department of Medicine at Stanford University, Chief of Medicine  at
Palo Alto Veterans Administration Hospital, and Director of Clinical
Research  at  the  University of Virginia School of  Medicine.   Dr.
Murad  was  the  1996  recipient of the  prestigious  Albert  Lasker
Medical Research award for achievement in medical science.

     Dr. Robert Pearlman The Board of Directors regretfully accepted
the  resignation  of board member Professor Robert Pearlman  of  the
University  of  Texas in November 1996.  As an important  scientific
and commercial collaborator with Tripos, Professor Pearlman believed
that his board position might be inconsistent with the University of
Texas conflict of interest policy.  Professor Pearlman will continue
to  serve  as  a  scientific advisor and will  continue  his  strong
collaborative product development relationship with Tripos.

      There are no family relationships among executive officers  or
directors  of  the Company.  No related party transactions  occurred
between the Company and any of the directors or their affiliates.


Board Meetings and Committees

      During  the fiscal year ended December 31, 1996, the Board  of
Directors of the Company held a total of nine (9) meetings.   During
this  period, each director attended or participated in all  of  (i)
the meetings of the Board that were held while they were members and
(ii)  the meetings held by all committees of the Board of which they
were members.

      The  Company has an Audit Committee, a Compensation Committee,
an  Executive  Committee, and a Technical Review  Committee  of  the
Board  of  Directors.  There is no nominating committee or committee
performing the functions of such committee.

       The  Audit  Committee  meets  with  the  Company's  financial
management  and its independent accountants at various times  during
each  year and reviews internal control conditions, audit plans  and
results,   and  financial  reporting  procedures.   This  Committee,
consisting  of Stewart Carrell, Ralph Lobdell, Gary Meredith,  Ferid
Murad  and  formerly, Robert Pearlman, held two (2) meetings  during
fiscal  1996.  Alfred Alberts will join the Audit Committee  at  its
next meeting.

      The  Compensation Committee reviews and approves the Company's
compensation   arrangements   for   management.    This   Committee,
consisting  of Ralph Lobdell, Stewart Carrell, Gary Meredith,  Ferid
Murad,  and formerly, Robert Pearlman, held two (2) meetings  during
fiscal  1996.   Alfred  Alberts has been added to  the  Compensation
Committee.

      The  Executive  Committee receives investment  proposals  from
within  and  without  the  Company and decides  whether  they  merit
consideration.  This Committee, consisting of Ralph Lobdell, Stewart
Carrell, Gary Meredith, Ferid Murad, and formerly,  Robert Pearlman,
held  five  (5)  meetings during fiscal 1996.   Alfred  Alberts  has
joined  the Executive Committee.

      The  Technical  Review  Committee  reviews  and  approves  the
mechanisms  by  which scientific and software development  decisions
are  made  by  the  Company.   This Committee,  consisting  of  John
McAlister,  Ferid  Murad, Robert Pearlman, as a scientific  advisor,
and  several key employees, did not meet during fiscal 1996.  Alfred
Alberts  will  join  the  Technical Review  Committee  at  its  next
meeting.


Director Remuneration

      Non-employee members of the Board, except for Mr. Lobdell, are
each paid an annual retainer of $10,000, and are reimbursed for  all
out-of-pocket costs incurred in connection with their attendance  at
all  Board  meetings and applicable committee meetings.  The  annual
retainer  is  paid quarterly in the form of 50% cash and  50%  stock
valued  at  the  then market rate.  Employee members  of  the  Board
receive no additional compensation for their service on the Board.

     Under the Tripos, Inc. 1994 Director Option Plan, an individual
who first becomes a non-employee member of the Board will receive an
automatic  option  grant for 10,000 shares of the  Company's  Common
Stock  upon commencement of Board service, and each individual  with
six or more months of Board service will receive an automatic option
grant  for  an  additional 2,500 shares on January 1 of  each  year.
Options  issued  under  the Tripos, Inc. 1994 Director  Option  Plan
become  exercisable at a rate of twenty-five percent  (25%)  of  the
shares  under  such option on each anniversary of the grant  of  the
option.   There are 300,000 shares reserved for issuance of  options
under the 1994 Director Option Plan, as amended.  The exercise price
for  the  options granted under the 1994 Directors  Option  Plan  is
equal  to  the fair market value of the Common Stock as of the  last
trading  day  immediately prior to the date the option  is  granted.
The  options  have  a  term  of  ten years.   However,  each  option
automatically terminates 90 days after the optionee ceases to  be  a
director  of  the Company except by reason of the optionee's  death,
disability,  or  employment  by the Company  or  a  subsidiary,  and
terminates within twelve (12) months after the occurrence of one  of
these stated events.

     Dr. Ferid Murad, receives a $1,000 fee for his role as Chairman
of  the Technical Review Committee for every meeting he attends, and
is  reimbursed  for  all  out-of  pocket  costs  incurred  with  his
attendance at such meetings.

      Mr.  Ralph  Lobdell receives an annual retainer of $25,000  as
Chairman of the Board for the Company, in lieu of the $10,000 annual
retainer  received  by  other non-employee  Board  members,  and  is
reimbursed  for all out-of-pocket expenses related to attendance  at
meetings  of the Board of Directors.  Mr. Lobdell's annual  retainer
is  paid  quarterly in the form of 50% cash and 50% stock valued  at
the  then market rate. The Board of Directors awarded a bonus to Mr.
Lobdell based on the results of 1996 in the amount of $25,000, which
was paid in 1997 in the form of 50% cash and 50% stock.

      No  other compensation is paid to the non-employee members  of
the Board with respect to service on the Board.

Recommendation of the Board of Directors

      The  Board of Directors recommends that the shareholders  vote
FOR the election of each of the above nominees.


                             PROPOSAL 2:
               AMENDMENT TO THE 1994 STOCK OPTION PLAN
                                  
      The Board of Directors of the Company adopted an amendment  to
the  1994 Stock Option Plan (the "1994 Plan") on March 17, 1997, and
directed that the amendment be submitted to the shareholders of  the
Company for their approval.  At the Annual Meeting, the shareholders
are  being  asked to approve an amendment to the Company's  existing
1994  Plan to increase the maximum aggregate number of shares  which
may  be  optioned  and sold under the Plan from seven  hundred  four
thousand (704,000) to one million one hundred thousand (1,100,000).

      The  1994  Plan is intended to provide additional compensation
and   incentive  to  key  employees  whose  present  and   potential
contributions are important to the continued success of the Company,
to  afford  such employees an opportunity to acquire  a  proprietary
interest  in  the Company and to enable the Company to  continue  to
attract and retain the best available talent.

General.   The  1994  Plan  was adopted in  March  1994  and  became
effective upon such date.  The 1994 Plan provides for the  grant  of
nonstatutory stock options to employees of the Company pursuant to a
discretionary grant mechanism.

Administration.  The 1994 Plan is designed to work as  an  incentive
performance  plan.  Options are granted by the President,  with  the
approval  of  the Compensation Committee of the Board of  Directors,
typically annually or upon promotions of key individuals.

Eligibility.   Only  employees or consultants  to  the  Company  are
eligible   under  the  1994  Plan.   Currently,  eighty-eight   (88)
employees participate in the 1994 Plan.

Terms  of  Options.   The  exercise  price  of  options  granted  to
employees must be 100% of the fair market value of the Tripos Common
Stock  on  the date of the grant.  The consideration for  exercising
options  granted  to  employees may only  consist  of  cash,  check,
previously owned shares of Tripos Common Stock or cashless exercise.
Options  granted to the employees have a ten year term,  or  shorter
upon termination of their tenure as an employee.  Options granted to
the  employees  vest at the rate of 25% on the first anniversary  of
the  grant and 1/48th per month for the next 36 months.  Outstanding
options  will expire on the earlier of ten years from  the  date  of
grant or 90 days after the employee receiving the grant ceases to be
employed by the Company.

Adjustment Upon Changes in Capitalization.  In the event any  change
is  made  in the Company's capitalization, such as a stock split  or
stock  dividend,  which results in a greater  or  lesser  number  of
shares of Tripos Common Stock, appropriate adjustment shall be  made
in  the  option  price and in the number of shares  subject  to  the
options.  In the event of the proposed dissolution or liquidation of
the  Company,  to the extent that an option or right  has  not  been
previously  exercised, it will terminate immediately  prior  to  the
consummation of such proposed action.  In the event of the merger or
sale  of  substantially  all  of the  assets  of  the  Company,  all
outstanding options shall be assumed or substituted by the successor
corporation, or if they are not assumed or substituted,  they  shall
become  fully  vested  unless  the  Board  of  Directors  determines
otherwise.

Amendment  and  Termination.  The Board of Directors may  amend  the
1994  Plan at any time or may terminate it without approval  of  the
shareholders.  However, no such action by the Board of Directors may
unilaterally alter or impair any option previously granted under the
1994  Plan  without the consent of the optionee.  In any event,  the
1994 Plan will terminate in March 2004.

Federal Income Tax Implications.  All options granted under the 1994
Plan are granted at the market price on the date of the grant.  As a
result,  no Federal income tax is due upon the receipt of the  grant
by  the employee.  Federal taxes will apply at the time the employee
recognizes  a  gain  from the exercise and sale  of  the  underlying
shares.

Reserve - Number of Shares Available.  Seven hundred four thousand
shares of Common Stock are currently reserved for issuance pursuant
to the 1994 Plan.  As of December 31, 1996, options to purchase
704,000 shares of Common Stock had been granted, of which, options
for 101,810 shares had been exercised.  Without taking into account
this proposed amendment to increase the maximum aggregate number of
shares, no shares remained available for future grants as of
December 31, 1996.  The amendment to the 1994 Plan will increase the
number of shares of Common Stock available for issuance pursuant to
the 1994 Plan from 704,000 to 1,100,000.

Recommendation of the Board of Directors

The Board of Directors recommends that the shareholders vote FOR the
amendment to the 1994 Stock Option Plan.
                                  
                       OWNERSHIP OF SECURITIES

     The following table sets forth, as of the Record Date, the name
of  each person who owns of record or is known by the Company to own
beneficially more than 5% of the outstanding shares of Common Stock,
the  number of shares owned by all directors, the executive officers
named  in  the  Summary  Compensation Table  (the  "Named  Executive
Officers") and all directors and executive officers as a group,  and
the  percentage of the outstanding shares represented thereby.   The
Company  believes that each of the directors and executive  officers
has  sole  voting  and investment power over such shares  of  Common
Stock.

Holders of More than 5%
                                  Amount and       
                                  Nature of           (1)
  Name and Address of             Beneficial       Percent of
  Beneficial Owner                Ownership          Class
                                                     
  State of Wisconsin               278,334 (2)          9.1%
  Investment Board
  P.O. Box 7842
  Madison, Wisconsin  53707
                                                     
  J.P. Morgan & Co., Inc.          233,400 (2)          7.7%
  60 Wall Street                   371,101 (3)
  New York, New York 10260
                                                     
  Vanguard//PRIMECAP Fund, Inc.    155,000 (2)          5.1%
  P.O. Box 2600
  Valley Forge, Pennsylvania  19482
                                                     
  FMR Corporation                  127,300 (2)          4.2%
  82 Devonshire                    201,000 (3)            
  Boston, Massachusetts  02109

Directors and Named Executive Officers:

                               Amount and            
                               Nature of            (1)
  Name of Beneficial Owner     Beneficial         Percent
                               Ownership         of Class
                                                     
  Ralph S. Lobdell               25,453             *
  Alfred Alberts                   -                -
  Stewart Carrell                12,240             *
  Gary Meredith                  2,865              *
  John P. McAlister III          65,639            2.2%
  Ferid Murad                      50               *
  Richard D. Cramer III          41,682            1.4%
  W. Ward Davidson III           24,784             *
  Mark W. Schwartz               24,659             *
  All   directors  and  named                        
  executive officers  as  a
  group   (9 persons)           197,372            6.5%

 *   Less than one percent of the outstanding Common Stock.
(1)   Percentage  of  beneficial ownership  is  calculated  assuming
3,049,175 shares of Common Stock were outstanding on April 4,  1997.
This  percentage also includes Common Stock of which such individual
or entity has the right to acquire beneficial ownership within sixty
days of April 4, 1997, including but not limited to the exercise  of
an   option;  however,  such  Common  Stock  shall  not  be   deemed
outstanding for the purpose of computing the percentage owned by any
other  individual or entity.  Such calculation is required  by  Rule
13d-3(d)(1)(i) under the Securities Exchange Act of 1934.
(2)   This  information is based on Schedules  13G  filed  with  the
Securities  and  Exchange  Commission (the  "SEC").   The  reporting
entity attests that they have sole voting and investment power  over
their reported shares of Common Stock.
(3)  This information is based on Schedules 13G filed with the  SEC.
The  reporting entity attests that they have sole dispositive  power
over their reported shares of Common Stock.
                                  
                             MANAGEMENT
                                  
Set forth below is certain information with respect to additional
executive officers and key employees of the Company not listed in
"Election of Directors":

     Name                Age       Title

Martin Bohl              54        Vice President, European Operations
Richard D. Cramer, III   55        Vice President, Scientific Activities
W. Ward Davidson, III    56        Vice President, Sales
Robert C. Glen           43        Vice President, Collaborative
                                    Discovery Services
John R. Hurst            40        Vice President, Discovery
                                    Software Science
Scott G. Hutton          36        Vice President, Marketing
Colleen A. Martin        36        Vice President, Chief Financial Officer,
                                    Secretary
James H. Munn            44        European Controller
David E. Patterson       45        Senior Fellow
Mark W. Schwartz         41        Vice President, Accelerated
                                    Discovery Services
Gregory B. Smith         37        Fellow
Martin Stuart            40        Vice President, Americas and
                                    Asia Pacific Sales
Paul L. Weber            38        Vice President, Software Development
Mary P. Woodward         51        Vice President, Business and
                                    Strategic Relations
John D. Yingling         40        U. S. Controller and Corporate Treasurer

      Dr. Martin Bohl obtained his training at the Friedrich Shiller
University of Jena in Germany, receiving the Diplom-Chemiker  degree
in  1974 and a Ph.D. in theoretical chemistry in 1979.  After  three
years  of  research and management at the Jenaer Glaswerk  Schott  &
Gen., Dr. Bohl joined the Academy of Sciences, Central Institute  of
Microbiology and Experimental Therapy in Jena.  During an eight-year
period,  Dr.  Bohl's  major  interests  included  structure-activity
relationships  of steroids.  Dr. Bohl joined Tripos in  1989  as  an
Application  and  Sales Support Scientist.  Other positions  he  has
held include: Manager of the Munich Sales Office, European Technical
Manager,  and General Manager for Central and Southern Europe.   Dr.
Bohl  was  promoted  to  Vice President of  European  Operations  in
October 1996.

      Dr.  Richard  D.  Cramer, III received his  A.B.  degree  from
Harvard  University in Chemistry and Physics in 1963, and his  Ph.D.
in  Physical  Organic Chemistry from the Massachusetts Institute  of
Technology in 1967.  Dr. Cramer worked for Polaroid Corporation from
1967 through 1969.  This was followed by a two year fellowship as  a
senior  member of the computer synthesis group at Harvard University
under direction of Dr. E. J. Corey.  Dr. Cramer joined Smith Kline &
French  Laboratories in 1971.  He was awarded a succession of titles
culminating  in Associate Director and Fellow, Medicinal  Chemistry.
Dr.  Cramer joined Tripos in 1983 as Vice President of New  Products
where  he  formulated the techniques of Comparative Molecular  Field
Analysis  (CoMFA), a patented software technology, at  Tripos.   Dr.
Cramer  was named Vice President of Scientific Activities  in  1988.
Dr.  Cramer  also  founded and currently  serves  on  the  Board  of
Directors of STATS, Inc.

      Mr. W. Ward Davidson, III obtained his B.S. in Psychology from
the  University  of  Maryland in 1966, and  is  a  graduate  of  the
Management  Development  Program at  Northeastern  University.   Mr.
Davidson  was  a Systems Analyst and a Marketing Representative  for
IBM  from  1966 through 1972.  In 1972, he joined Digital  Equipment
Corporation, where he spent 12 years in Senior Sales Management  and
Operations Management.  From 1984 until 1992 Mr. Davidson  was  Vice
President,  Sales  for  Culler  Scientific,  a  mini-super  computer
manufacturer and Vice President, Sales for Wavefront Technologies, a
3-D  animation  software  company.  Mr. Davidson  joined  Tripos  in
January 1992, as Vice President of Sales.

      Dr.  Robert C. Glen  received his B.S. in Chemistry  from  the
University  of Paisley, Scotland in 1978 and his Ph.D. in  Chemistry
and  X-ray Crystallography from the University of Stirling in  1982.
Dr.  Glen  was  a  Senior Physical Chemist with  responsibility  for
computer-aided  molecular  design (CAMD) at  the  Wellcome  Research
Laboratories, in London, from 1982 to 1987.  After a short period at
ICI  Pharmaceuticals,  Dr. Glen returned to  Wellcome  as  a  Senior
Research  Scientist  responsible for CAMD, Protein  Crystallography,
measured  physico-chemical  properties  and  Quantitative  Structure
Activity  Relationships.  Dr. Glen has published over 50  papers  in
drug discovery and holds a number of patents on drugs in the clinic,
including  311C90 for the treatment of migraine.   Dr.  Glen  joined
Tripos  in  June  1995 as Senior Director of Science.   In  February
1996,  Dr.  Glen  was promoted to Senior Director  of  Collaborative
Discovery  Services  and  to Vice President Collaborative  Discovery
Services in August 1996.

      Dr.  John  R. Hurst  received B.S. degrees in Mathematics  and
Chemistry  from  Rose  Hulman Institute in 1978  and  his  Ph.D.  in
Physical-Organic   Chemistry  from  the  University   of   Illinois,
Champaign in 1983.  Dr. Hurst held a post-doctoral position  at  the
University   of   Texas,  Austin  in  Electro-photochemistry   under
Professor Marye Anne Fox.  In 1984 he joined Monsanto Corporation as
Research  Information Systems Manager.  Dr. Hurst joined  Tripos  in
1989 to begin the development of Chemical Information Systems.   Dr.
Hurst was promoted to Vice President of Marketing-Discovery Software
in November 1995 and named Vice President Discovery Software Science
in August 1996.

      Mr. Scott G. Hutton received his Bachelor of Science degree in
Chemistry  from the University of Missouri, Columbia, in 1984.   Mr.
Hutton worked as a Chemist at Monsanto Corporation from 1985 to 1988
and subsequently as a Technical Sales and Service Representative  at
the  Waters  Division of Millipore from 1988  to  1990.   He  joined
Tripos  as an Account Executive in 1990 and was promoted to Regional
Sales  Manager  in 1992.  In 1994, Mr. Hutton was named  U.S.  Sales
Manager and promoted to Vice President of Marketing in August 1996.

      Ms.  Colleen A. Martin received her Bachelor of Science degree
in  Accounting from the University of Missouri, St. Louis,  in  1982
and  has  attended  Northwestern University's J.L. Kellogg  Graduate
School  of  Management Executive Programs.  Ms. Martin, a  Certified
Public  Accountant, worked on the audit staff for KPMG Peat  Marwick
LLP from 1982 through 1984 and worked for Continental Cablevision as
District  Controller  from 1984 through  1989.   Ms.  Martin  joined
Tripos in June 1989 as Controller and was promoted to Vice President
and Chief Financial Officer in April 1995.

     Mr. James H. Munn received both a B.A. in Biology in 1974 and a
M.S.  in  Accounting  in 1978 from California  State  University  at
Northridge.  Mr. Munn, a Certified Public Accountant, worked on  the
audit staff of Price Waterhouse from 1979 through 1980.  In 1980  he
joined  Tiger International as a Senior Financial Analyst  and  from
1983  through  1985 he was employed at Loral EOS  as  Supervisor  of
Accounting  Operations.  From 1985 to 1995, Mr.  Munn  held  various
financial  management positions at Radio Free Europe/Radio  Liberty,
Inc.,  Munich,  Germany.  Mr. Munn joined Tripos  in  July  1995  as
European Controller.

       Mr.   David  E.  Patterson   received  his  B.S.  in  Applied
Mathematics  and  Computer Science in 1974  and a  M.S.  in  Systems
Science  in  1980  from Washington University  in  St.  Louis.   Mr.
Patterson worked as a Senior Research Scientist with the Center  for
Air  Pollution  Impact and Trend Analysis from  1976  until  joining
Tripos  in  1986.  His positions have included Product  Manager  for
QSAR and Senior Director of New Products prior to being promoted  to
Senior Fellow in March 1996.

     Dr. Mark W. Schwartz received his B.A. degree in Chemistry from
Grinnell College in 1977 and his Ph.D. in Biochemistry from  Arizona
State University in 1983.  Dr. Schwartz worked for E.I. duPont  from
1983  through  1989  in  research  and  development  positions   for
diagnostic  products  before moving into a  marketing  position  for
biotechnology products.  This was followed by several marketing  and
product  management positions at Applied Biosystems, before  joining
Biosym  Technologies in 1991 as Marketing Director,  Life  Sciences.
Dr.  Schwartz joined Tripos as Vice President of Marketing in  March
1994.   In  November 1995 he was named Vice President  of  Corporate
Marketing  and  Discovery  Services and Vice  President  Accelerated
Discovery Services in August 1996.

      Mr.  Gregory  B. Smith received his B.S. and M.S.  degrees  in
Computer Science from Washington University in 1983. As part of  his
graduate  thesis,  he worked on the team which developed  the  first
SYBYL/VAX  prototype  under contract to Tripos.   Mr.  Smith  joined
Tripos  in  1986  as a member of the technical staff  where  he  was
responsible  for all graphics, systems, and quality control  related
activities.  Mr. Smith was named Director of New Technology in  1990
and  in  1994  was  named Vice President of Technology  and  Quality
Standards.  In 1996 he became a Fellow, with responsibility for  the
corporate databases.

      Dr.  Martin Stuart received his Bachelor of Science in Physics
and  Mathematics  from the Council for National Academic  Awards  in
London in 1982.  He was awarded a Ph.D. in the Physics of Thin Films
from  the University College of North Wales 1986.  Dr. Stuart  is  a
member  of  the  Institute of Physics and is a Chartered  Physicist.
Dr.  Stuart  joined  3M Company in 1974 and held several  scientific
positions,  and  ultimately, Senior Research  Scientist.   His  work
ranged from optimization of photographic development systems to  the
design of highly efficient drug delivery systems.  Dr. Stuart joined
Tripos  in  1987 to support its products in the United  Kingdom  and
Scandinavia.   He was promoted to Manager of Asia Pacific  Sales  in
1993.  Dr. Stuart was promoted to Vice President of the Americas and
Asia Pacific Sales in February 1996.

      Dr. Paul L. Weber  obtained his Bachelor of Science degrees in
Chemistry and Honors Biology from the University of Illinois, Urbana
in  1981.   He  was  awarded  his Ph.D.  in  Biochemistry  from  the
University of Washington, Seattle in 1985.  Prior to joining Tripos,
Dr.  Weber  was  employed as Director of Scientific Applications  at
Hare Research, Inc. where he was involved with business development,
customer  support, sales and program documentation, development  and
debugging.   Dr.  Weber joined Tripos in January  1991  as  the  NMR
Project  Manager.   In  January 1995,  Dr.  Weber  was  promoted  to
Director  of Software Development.  In November 1995, Dr. Weber  was
promoted to Vice President of Software Development.

      Ms.  Mary  P.  Woodward  obtained her  B.A.  in  English  from
Creighton  University  in  1967,  her  M.A.  in  English  from   the
University  of  Kansas  in  1969, and  has  taken  courses  in  high
technology,  international marketing and strategic alliance  offered
in  the  Berkeley, Stanford, and Northwestern J.L. Kellogg  Graduate
School  of  Management Executive Programs.  Since joining Tripos  in
1983,  Ms. Woodward has held a series of sales, legal, and marketing
administration positions, and is currently Vice President,  Business
and Strategic Relations.

      Mr.  John D. Yingling  received his Bachelor of Science degree
in  Accounting from the University of Missouri, St. Louis,  in  1979
and  holds  certificates  as a Certified  Public  Accountant  and  a
Certified  Cash  Manager.  Mr. Yingling worked for Storz  Instrument
Company,  a micro-surgical instrument manufacturer, in a  series  of
accounting  positions  from 1979 to 1983 and for  Clayton  Brokerage
Company from 1983 to 1985.  This was followed by several accounting,
tax  and  treasury positions at Venture Stores, Inc.  from  1985  to
1995.  Mr. Yingling joined Tripos in May 1995 as U.S. Controller and
assumed the Corporate Treasurer responsibilities in March 1997.
                                  
                                  
           EXECUTIVE COMPENSATION AND RELATED INFORMATION
                                  
Summary of Cash and Certain Other Compensation

   The  following table sets forth the compensation  earned  by  the
Named Executive Officers for services rendered in all capacities  to
the Company and its subsidiaries for the fiscal years ended December
31, 1996, December 31, 1995, and December 31, 1994.

                     SUMMARY COMPENSATION TABLE
                                  
                                                  Long-Term           
                               Annual           Compensation         
                            Compensation           Awards
                                                      Securities  All Other
                                               LTIP   Underlying  Compensation 
Name & Principal    Year    Salary   Bonus    Payouts  Options      ($) (5)
   Position                ($) (1)  ($) (2)    $ (3)   # (4)
                                                                      
John P. McAlister   1996   150,000       -    17,949    15,000       4,500
    President and   1995   150,000  20,000         -    15,000       3,465
  Chief Executive   1994   149,808       -    30,476   100,000       3,446
          Officer                                        2,667
                                                           889
                                                                      
Richard D. Cramer   1996   115,000       -     4,711     5,000           -
  Vice President,   1995   106,800   8,000         -     5,000       2,772
       Scientific   1994   104,810  15,000         -    55,000       2,772
       Activities                                          700
                                                           234
                                                                      
W. Ward Davidson    1996   120,000  76,881         -         -       8,750
  Vice President,   1995   124,932  70,068         -     2,500       7,723
            Sales   1994   118,615  46,262         -    37,500       8,228
                                                                      
Mark W. Schwartz    1996   115,000  27,511         -     2,500       4,275
  Vice President,   1995   106,169  12,000         -    22,500       2,279
      Accelerated   1994    79,423       -         -    15,000         656
Discovery Services

(1)   Includes salary deferred under the Company's 401(k) Plan.  Dr.
Schwartz's  1994  compensation reflects his  compensation  from  his
actual date of hire, March 30, 1994.
(2)   Bonuses  earned were based on an allocation of a discretionary
bonus  pool.  There were no bonuses earned through the discretionary
bonus  pool in 1995.  Discretionary bonuses were accrued  in  fiscal
1994  and paid out in 1995 as was the case with fiscal 1993  bonuses
being accrued and paid out in 1994.   Bonuses for fiscal years 1994,
1995  and  1996  for Mr. Davidson were earned based  on  commissions
payable  upon the Company's achievement of targeted revenue  levels.
Bonus  for  1996  for Mr. Schwartz was earned based  on  commissions
payable upon the Company's achievement of targeted revenue levels.
(3)   LTIP  Payouts represent the gain on the sale of stock  options
exercised  under  the Evans & Sutherland Computer  Corporation  1985
Stock Option Plan for Key Employees granted and vested prior to  the
distribution  of the Company's stock by Evans & Sutherland  Computer
Corporation  ("E&S")  to  its shareholders  on  June  1,  1994,  the
("Distribution").
(4)   The  number of shares underlying option grants include options
granted to Tripos employees under the 1994 Stock Option Plan and the
Evans  & Sutherland Computer Corporation 1985 Stock Option Plan  for
Key Employees.
(5)   "All  Other Compensation" includes a matching contribution  to
the Company's 401(k) Plan and a car allowance for Mr. Davidson.


Stock Options

   The following table contains information concerning the grant  of
stock options made to the Named Executive Officers in 1996.

                OPTION/SAR GRANTS IN LAST FISCAL YEAR
                                  
                                                                        
                   Individual Grants                          
                                                               Potential
                                                               Realizable    
                                                                  Value
                  Number      % of                             at Assumed  
                    of        Total                               Annual
                Securities   Options/                           Rates of  
                 Options/     SARs                             Stock Price  
                Underlying   Granted   Exercise                 Appreciation
                 Options/      to       Price                       for
                   SARs     Employees    Per   Expiration      Option Term
       Name      Granted    in Fiscal   Share     Date       5% (3)     10%(3) 
                              Year     ($) (2)               
John P. McAlister 15,000(1)    7.7%     6.50     5/9/06    $61,300   $155,400
Richard D. Cramer  5,000(1)    2.6%     7.88    3/28/06    $24,800   $ 62,800 
W. Ward Davidson       -         -         -          -    $     -   $      - 
Mark W. Schwartz   2,500(1)    1.3%     7.88    3/28/06    $12,400   $ 31,400
                                                                         

(1)   The  options granted under the 1994 Stock Option  Plan  become
exercisable  as to 25% of the option shares on the first anniversary
of  the  grant date and 1/48th per month for three years thereafter.
The  options have a 10-year term, subject to earlier termination  in
the event of the optionee's cessation of service with the Company.
(2)   The  exercise  price of each option may be paid  in  cash,  in
shares  of Common Stock valued at fair market value on the  exercise
date  or  through a cashless exercise procedure involving a same-day
sale of the purchased shares.
(3)   The  five  percent (5%) and ten percent (10%)  assumed  annual
rates  of  compounded stock price appreciation are mandated  by  the
rules  of  the  Securities  and Exchange Commission.   There  is  no
assurance  provided to any executive officer or any other holder  of
the  Company's  securities that the actual stock price  appreciation
over the 10-year option term will be at the assumed 5% or 10% levels
or at any other defined level.

Option Exercises and Holdings

      The  following table provides information with respect to  the
Named  Executive Officers concerning unexercised options held as  of
the end of the 1996 fiscal year.

           AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                  AND FISCAL YEAR-END OPTION VALUES
                                  

                                        Number of                 
                                       Securities
                  Shares               Underlying       Value of Unexercised
                 Acquired              Unexercised      in-the-Money Options
                                       Options at                at
      Name          on     Value      Year-End 1996       Fiscal Year-End
                 Exercise Realized  Exercis  Unexercis  Exercis     Unexercis
                    #        $         able      able      able         able
John P. McAlister   889    $1,968    53,750    76,250   $365,625(1) $500,625
                  2,667   $17,949         0         0         $0(2)       $0
Richard D. Cramer 6,234   $75,831    35,510    23,490   $235,240(1) $137,385
                    700    $4,711         0         0         $0(2)       $0
W. Ward Davidson  1,600   $15,800    22,828    15,572   $151,861(1) $101,713
Mark W. Schwartz  1,872   $16,380    18,284    19,844   $130,099(1) $135,549
                                                                       

(1)   Based  on  the  fair market value of Tripos Common  shares  on
December 31, 1996 ($11.75 per share).
(2)  Options to purchase shares of E&S Common Stock were granted to
certain key executives prior the spin-off of the Company in June,
1994.
                                  
                                  
                REPORT OF THE COMPENSATION COMMITTEE
                                  
      The  following is the Report of the Compensation Committee  of
the   Board   of   Directors  ("the  Committee"),   describing   the
compensation  policies  and rationale applicable  to  the  Company's
executive  officers with respect to the compensation  paid  to  such
executive  officers  for  the year ended  December  31,  1996.   The
Compensation Committee of the Board of Directors is responsible  for
setting  the  general compensation policies of  the  Company,  which
include  specific compensation levels for executive officers,  bonus
pools,  and  the  1994  Tripos Employee Stock  Option  Plan.   These
programs and the Committee's compensation philosophy are designed to
attract   and   retain  key  executives  by  providing   appropriate
incentives linked to Company performance. The Committee is  composed
of all non-employee Directors.

Compensation Philosophy

      The  Compensation Committee evaluates the performance  of  the
Chief  Executive Officer and other officers of Tripos annually based
upon  financial and non-financial performance goals which contribute
to the profitability of the Company.  The Compensation Committee has
approved  compensation policies that seek to enhance the linkage  of
compensation  to Company objectives and overall company performance.
The  executive  officers' compensation package is comprised  of  (i)
base  salary, (ii) annual incentive opportunity tied to  achievement
of  Operating Income and other goals, and (iii) long-term incentives
established  to align management with shareholders, in the  form  of
stock   options.  The  Chief  Executive  Officer  recommends  annual
increases for other executives for review and approval by the Board.

                     Base  Salaries --   Individual salary increases
          are  likely to be based on a variety of factors including,
          but  not limited to: competitive salary levels, individual
          job  responsibilities, results versus  target  objectives,
          and Company financial performance.

                     Annual Incentives -- Effective for fiscal  1995
          and  later years, the Company's officers were eligible  to
          participate  in  an  annual incentive  compensation  plan.
          Annual  incentive targets are set as a percent  of  salary
          for  each  officer based on attainment of financial  goals
          including  Operating  Income  and  individual  performance
          goals.   Weighting  of goals varies by participant.   Over
          120%  of the Operating Income goal was achieved in  fiscal
          1996,  therefore a payout related to financial  goals  was
          made in early 1997.  No payout was made in 1996 for fiscal
          1995.

                     Long-term Incentives -- The Company has adopted
          the  1994  Tripos Stock Option Plan to attract and  retain
          the  best available personnel for positions of substantial
          responsibility,   to  provide  additional   incentive   to
          employees,  and  to promote the success of  the  Company's
          business.  Awards under the 1994 Tripos Stock Option  Plan
          are  designed  to give the recipient a significant  equity
          stake  in  the  Company and thereby  closely  align  their
          interests  with those of the Company's shareholders.    In
          fiscal  year  1994, the Board and Committee granted  stock
          options  to  officers and other employees under  the  1994
          Tripos Stock Option Plan subsequent to the distribution of
          the   Company's  stock  by  Evans  &  Sutherland  Computer
          Corporation ("E&S") to its shareholders on June  1,  1994,
          the   ("Distribution").  The  Committee  has   established
          certain  general  guidelines in making  option  grants  to
          executive officers in an attempt to target a fixed  number
          of  unvested  option  shares based upon  the  individual's
          position with the Company and his or her existing holdings
          of unvested options.  The number of shares granted to each
          executive officer in fiscal years 1996, 1995 and 1994  was
          based  upon the officer's tenure, level of responsibility,
          and  relative  position  in  the  Company.   However,  the
          Committee does not adhere strictly to these guidelines and
          will  occasionally vary the size of the option grant  made
          to each executive officer as circumstances warrant.


Chief Executive Officer Compensation

     The  Chairman  and other members of the Compensation  Committee
meet  semi-annually  with  Dr. McAlister  to  discuss  his  personal
performance during the fiscal year.  The Committee's objective is to
have  Dr. McAlister's base salary keep pace with the salaries  being
paid  to similarly situated CEOs in the software and high technology
industries,  and reflect individual performance and  achievement  of
Tripos  corporate  goals.  Dr. McAlister's base salary  is  reviewed
annually  by  the Compensation Committee based on these  discussions
and other criteria mentioned above.

      Notwithstanding anything to the contrary set forth in  any  of
the  Company's previous filing under the Securities Exchange Act  of
1934  that  might incorporate future filings, including  this  Proxy
Statement,  in  whole  or  in part, the  foregoing  report  and  the
Performance  Graph  which  follows  shall  not  be  deemed   to   be
incorporated by reference into any such filing.

          Compensation Committee
          Mr. Ralph S. Lobdell, Chairman
          Mr. Stewart Carrell
          Mr. Gary Meredith
          Dr. Ferid Murad
          Mr. Alfred Alberts

                  COMPARISON OF SHAREHOLDER RETURN
                                  
        Indexed Comparison of Total Return since Distribution
        Total Return Index for the NASDAQ National Market and
   Total Return for NASDAQ Computer and Data Processing Companies

               (Stock performance graph inserted here)

             6/1/94   12/31/94   6/30/95   12/31/95   6/30/96   12/31/96   

NASDAQ       100.00    103.12    128.59     145.83    165.10     179.39

Data
Processing   100.00    114.64    152.95     174.59    203.17     215.61

Tripos, Inc  100.00     86.36    113.64     154.55    159.09     213.64


Note:      Assumes $100 invested on 6/1/94 in the Company, the total
return  index  for the NASDAQ National Market and the  total  return
index  for  NASDAQ Computer and Data Processing Companies.   Assumes
reinvestment of dividends on a daily basis.

      The  graph covers the period from June 1, 1994, the  date  the
Company's distribution of Common Stock to holders of record  of  the
Common  Stock  of  E&S  commenced, through  the  fiscal  year  ended
December 31, 1996.  The graph assumes that $100 was invested on June
1, 1994 in the Company's Common Stock and in each index and that all
dividends were reinvested.  No cash dividends have been declared  on
the  Company's Common Stock.  Shareholder returns over the indicated
period  should  not  be considered indicative of future  shareholder
returns.


                            ANNUAL REPORT
                                  
      A copy of the Annual Report of the Company for the fiscal year
ended December 31, 1996 has been mailed concurrently with this Proxy
Statement to all shareholders entitled to notice of and to  vote  at
the  Annual  Meeting. The Company filed a Form 10-K  with  the  SEC.
Shareholders may obtain a copy of the Form 10-K without  charge,  by
writing  to  Colleen Martin/Corporate Secretary,  at  the  Company's
executive  offices  at 1699 South Hanley Road, St.  Louis,  Missouri
63144.

             SELECTION OF INDEPENDENT PUBLIC ACCOUNTANTS
                                  
       Ernst  & Young LLP, independent certified public accountants,
has been selected by the Board of Directors as the firm to audit the
accounts  and to report on the financial statements of  the  Company
for the current fiscal year ending December 31, 1997.  Neither Ernst
&  Young  LLP,  nor  any of its members has any financial  interest,
direct  or indirect, in the Company, nor has Ernst & Young LLP,  nor
any of its members ever been connected with the Company as promoter,
underwriter, voting trustee, director, officer or employee.   It  is
anticipated  that a representative of Ernst & Young LLP will  attend
the  meeting  and  shall  be  available to  respond  to  appropriate
questions.  It is not anticipated that the representative from Ernst
& Young LLP will make any statement or presentation.



                            OTHER MATTERS
                                  
      The  Board  of  Directors does not know of any matters  to  be
presented  at this Annual Meeting other than those set forth  herein
and in the Notice accompanying this Proxy Statement.

                                   TRIPOS INC.


                                   Colleen A. Martin
                                   Corporate Secretary

                                   April 9, 1997
                                   St. Louis, Missouri



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