TRIPOS INC
DEF 14A, 1998-04-09
PREPACKAGED SOFTWARE
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Company Logo

TRIPOS, INC.

To Our Shareholders:


     You are invited to attend the Annual Meeting of Shareholders of
Tripos,  Inc. to be held at 1:00 p.m. local time on May 7,  1998  at
the  World  Trade  Center  St. Louis, 121 S.  Meramec,  10th  Floor,
Clayton,  Missouri, 63105.  At this meeting you are being  asked  to
vote  on  several matters recommended by the Board of  Directors  of
Tripos, Inc.  We want to emphasize the importance of proposals 2 and
3,  our  two  stock plan proposals, to our future success.   We  are
requesting your approval of these proposals to allow us to  attract,
retain and motivate highly qualified employees, and thus enhance the
value  of  the Company.  Proposal 3, when considered in  conjunction
with  the  Board of Directors' commitment to reduce  the  number  of
shares reserved under the Director Stock Plans (as described below),
will  not  result  in an aggregate increase in the total  number  of
shares reserved under the Company's stock option plans.

      An  important  focus in establishing employee compensation  at
Tripos is the relationship between long-term compensation and  stock
price,  achieved  through the judicious award of stock  options  and
participation by our employees in the Company's 1994 Employee  Stock
Purchase  Plan ("1994 ESP Plan").  We believe these two stock  plans
are key ingredients to our prospects of success.

      The Board and management continue to examine the benefits  and
costs  of Tripos' compensation philosophy.  The Company periodically
engages  compensation  attorneys  and  consultants  who  advise  the
Company  on the most effective methods and levels of employee  stock
compensation.   This  is admittedly a difficult  process  with  many
factors that must be frequently revisited.

      First,  we  must ensure we are able to continue  to  hire  and
retain  qualified individuals to support the needs  of  our  rapidly
growing  business.  We are satisfied that our prior option  granting
practices  have been a critical factor in our ability  to  hire  and
retain individuals whose collective contributions have greatly added
to  Tripos'  success.    At  this time, 67%  of  our  technical  and
professional  employees hold unvested stock options.   We  recognize
these   employees   have  portable  skills   and   frequently   have
opportunities to accept other employment, and we believe  our  broad
and inclusive policy of granting stock options is a strong factor in
our  successful efforts to hire, retain and motivate employees.   We
have  been  informed  that our technical and  professional  employee
turnover  rate is significantly lower than that of comparable  high-
tech companies.  Tripos has greatly benefited from being better able
to  focus  on the needs of our dynamic business instead of  spending
extra  dollars to recruit, relocate, assimilate and train even  more
new employees.

     Second, we must balance the costs of stock compensation against
other benefits.  The Company has established a 401(k) plan, but  has
not  established an employee retirement pension program.  We believe
equity  awards are the most attractive and cost-effective  means  to
assist  employees in planning for their long-term  needs.   Employee
participation in the Company's 1994 ESP Plan reaffirms  this  belief
and  vividly demonstrates our employees' faith in Tripos  and  their
willingness to work hard for its success.  At December 31, 1997, 60%
percent  of  eligible employees participated in the 1994  ESP  Plan.
Due  to the value of this plan to the employees, 106,553 shares  had
been purchased from the reserve since the plan's inception leaving a
balance available for purchase of 43,447 shares.  In the event  that
this reserve is not replenished, the Company could only continue the
1994  ESP  Plan  through the purchase of shares on the  open  market
using  current cash reserves.  The Board of Directors believes  that
these  current  cash reserves should be utilized for investment  and
expansion of the Company to maximize shareholder value.

     Let us assure you that the Board of Directors is very sensitive
to  the dilutive nature of employee stock plans.  With this in mind,
the  Board has resolved that, upon approval of proposal 3,  (i)  the
Company's 1994 Director Stock Option Plan shall be amended to reduce
the  number  of shares reserved thereunder from 300,000  to  240,000
shares, and (ii) the Company's 1996 Director Compensation Plan shall
be amended to reduce the number of shares thereunder from 200,000 to
80,000  shares.  The purpose of such reductions is to eliminate  the
dilutive  impact  of  proposal  3 so  that,  upon  approval  of  the
proposal, the total number of shares subject to issuance pursuant to
the  Company's stock option plans shall remain the same.  The  Board
believes that such "reallocation" of shares from the director  stock
plans  to the employee stock option plan is in the best interest  of
the  Company  and  its  employees  and  is  calculated  to  maximize
shareholder value.

     We truly believe that approval of these proposals will continue
to  enhance  the  value  of Tripos' stock.  As  illustrated  in  the
Performance  Graph on page 14 of the proxy statement, the  Company's
stock  price  increased  approximately 24% during  fiscal  1997  and
approximately 207% over the last three complete fiscal  years.   The
Board and management strongly support approval of proposals 2 and  3
to help ensure we continue on this successful path.



                                   Sincerely,
                                   
                                   
                                   
                                   _____________________________
                                   Ralph S. Lobdell
                                   Chairman of the Board of
                                   Directors






                            Company Logo
                                  
                            TRIPOS, INC.
                                  
                                  
              NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                       To Be Held May 7, 1998
                                  
To Our Shareholders:

      The  Annual  Meeting  of Shareholders  of  Tripos,  Inc.  (the
"Company") will be held at the World Trade Center St. Louis, 121  S.
Meramec,  10th  Floor, Clayton, Missouri, 63105 at 1:00  p.m.  local
time on May 7, 1998 for the following purposes:

     1.  To elect directors to serve for the ensuing year or until their
         successors are elected;
     
     2.  To amend the 1994 Employee Stock Purchase Plan to increase the
         number of shares reserved thereunder from 150,000 to 350,000 shares;
     
     3.  To amend the 1994 Stock Option Plan to increase the number of
         shares reserved thereunder from 1,100,000 to 1,280,000 shares;
     
     4.  To act upon such other business as may properly come before the
         Annual Meeting or at any adjournments or postponements thereof.

     The Board of Directors has fixed the close of business on April
3,  1998  as the record date for determining those shareholders  who
will be entitled to notice of and to vote at the Annual Meeting.

     Representation of at least a majority of all outstanding shares
of  Common Stock of the Company is required to constitute a  quorum.
Accordingly, it is important that your shares be represented at  the
meeting.   WHETHER  OR  NOT YOU PLAN TO ATTEND THE  ANNUAL  MEETING,
PLEASE COMPLETE, DATE AND SIGN THE ENCLOSED PROXY FORM AND RETURN IT
IN  THE  ENCLOSED ENVELOPE.  You may revoke your proxy at  any  time
prior to the time it is voted.  If you attend the Annual Meeting and
vote  by  ballot, your proxy will be revoked automatically and  only
your vote at the Annual Meeting will be counted.

                                             Sincerely,



                                             Colleen A. Martin
                                             Corporate Secretary

St. Louis, Missouri
April 7, 1998
                                  
                                  
                                  
         Shareholders Should Read the Entire Proxy Statement
           Carefully Prior to Returning Their Proxy Forms
                                  
                           PROXY STATEMENT
                                 FOR
                  ANNUAL MEETING OF SHAREHOLDERS OF
                            TRIPOS, INC.
                                  
                       To Be Held May 7, 1998
                                  
      This  Proxy  Statement  is furnished in  connection  with  the
solicitation by the Board of Directors of Tripos, Inc. ("Tripos"  or
the  "Company")  of  proxies to be voted at the  Annual  Meeting  of
Shareholders which will be held at 1:00 p.m. local time  on  May  7,
1998  at  the  World Trade Center St. Louis, 121  S.  Meramec,  10th
Floor,   Clayton,   Missouri  63105,  or  at  any  adjournments   or
postponements   thereof,  for  the  purposes  set   forth   in   the
accompanying Notice of Annual Meeting of Shareholders.   This  Proxy
Statement and the accompanying proxy form are first being mailed  to
shareholders on or about April 7, 1998.

                   VOTING RIGHTS AND SOLICITATION
                                  
      The close of business on April 3, 1998 was the record date for
shareholders  entitled  to  notice of and  to  vote  at  the  Annual
Meeting.   As  of that date, Tripos had 3,178,959 shares  of  Common
Stock,  $.01  par value per share (the "Common Stock"),  issued  and
outstanding.   All  of  the  shares of the  Company's  Common  Stock
outstanding  on the record date are entitled to vote at  the  Annual
Meeting, and shareholders of record entitled to vote at the  meeting
will  have one (1) vote for each share so held on the matters to  be
voted upon.

      Shares of the Company's Common Stock represented by proxies in
the  accompanying form that are properly executed  and  returned  to
Tripos  will  be  voted  at the Annual Meeting  of  Shareholders  in
accordance  with  the shareholders' instructions contained  therein.
In  the absence of contrary instructions, shares represented by such
proxies  will be voted FOR the election of each of the directors  as
described herein under "Proposal 1 -- Election of Directors" and FOR
the  amendment to the 1994 Employee Stock Purchase Plan as described
herein  under  "Proposal 2 -- Amendment to the 1994  Employee  Stock
Purchase Plan" and  FOR  the amendment to the 1994 Stock Option Plan
as  described herein under "Proposal 3 - Amendment to the 1994 Stock
Option  Plan".   Management  does not know  of  any  matters  to  be
presented in this Annual Meeting other than those set forth in  this
Proxy Statement and in the Notice accompanying this Proxy Statement.
If  other matters should properly come before the meeting, the proxy
holders  will  vote on such matters in accordance  with  their  best
judgment.  Any shareholder has the right to revoke his or her  proxy
at  any  time before it is voted.  A proxy may be revoked either  by
written  notice to the Secretary of the Company or by attending  the
meeting and voting in person.  A majority of the outstanding  shares
of  Common  Stock, present in person or represented by  proxy,  will
constitute  a quorum for the transaction of business at  the  Annual
Meeting.  The affirmative vote of a plurality of the shares present,
in  person or by proxy, at the Annual Meeting, is required to  elect
directors.   "Plurality"  means that the nominees  who  receive  the
largest  number  of votes cast are elected as directors  up  to  the
maximum  number  of directors to be elected at the  Annual  Meeting.
Consequently, marking the proxy ballot to withhold a vote for one or
more  nominees  does  not have the effect of  a  vote  against  said
nominee(s), but will have an effect on the number of votes  cast  in
the election and could effect the outcome.  The affirmative vote  of
a  majority of the shares casting votes, which are present in person
or by proxy at the Annual Meeting, is required to approve Proposal 2
and  Proposal  3  and to act on any other matters  properly  brought
before this meeting.  Shares represented by proxies which are marked
"withhold authority" with respect to the election of any one or more
of  the  nominees  for election of directors and proxies  which  are
marked  "abstain" with respect to Proposals 2 and 3 will be  counted
for  the purpose of determining the number of shares represented  by
proxy at the meeting and the presence or absence of a quorum.  If no
specification  is made on a duly executed proxy, the proxy  will  be
voted  FOR  election  of the directors nominated  by  the  Board  of
Directors  and  FOR Proposal 2 and FOR Proposal 3.  Abstentions  and
broker  non-votes  are  each included in the  determination  of  the
number  of  shares  present  for quorum purposes.   Abstentions  are
counted  in tabulations of the votes cast on proposals presented  to
shareholders, whereas broker non-votes are not counted for  purposes
of determining whether a proposal has been approved.

      The entire cost of soliciting proxies will be borne by Tripos.
Proxies will be solicited principally through the use of the  mails,
but,  if  deemed  desirable,  may  be  solicited  personally  or  by
telephone, telefax or special letter by officers and regular  Tripos
employees for no additional compensation.  The Board of Directors of
the  Company has engaged ChaseMellon Shareholder Services to provide
routine  advice  and  services.  Arrangements have  been  made  with
brokerage  houses and other custodians, nominees and fiduciaries  to
send  proxies  and proxy materials to the beneficial owners  of  the
Company's  Common  Stock, and such persons shall be  reimbursed  for
their reasonable expenses.
                                  
                        SHAREHOLDER PROPOSALS
                                  
      Shareholder proposals intended to be considered  at  the  1999
Annual  Meeting of Shareholders must be received by Tripos no  later
than  December  11,  1998.   The proposal  must  be  mailed  to  the
Company's  principal executive offices, 1699 South Hanley Road,  St.
Louis,  Missouri   63144,  Attention:  Corporate  Secretary.    Such
proposals  may  be included in next year's proxy statement  if  they
comply  with  certain  rules  and  regulations  promulgated  by  the
Securities and Exchange Commission.



             MATTERS TO BE CONSIDERED AT ANNUAL MEETING
                                  
                             PROPOSAL 1:
                                  
                        ELECTION OF DIRECTORS

      The  nominees for the Board of Directors are set forth  below.
The proxy holders intend to vote all proxies received by them in the
accompanying form for the nominees for directors listed  below.   In
the  event any nominee is unable or declines to serve as a  director
at the time of the Annual Meeting, either the size of the Board will
be reduced or the proxies will be voted for any nominee who shall be
designated  by the present Board of Directors to fill  the  vacancy.
In  the event that additional persons are nominated for election  as
directors, the proxy holders intend to vote all proxies received  by
them  for  the nominees listed below.  As of the date of this  Proxy
Statement, the Board of Directors is not aware of any nominee who is
unable  or will decline to serve as a director.  The directors  will
serve for a one year term, or until their respective successors  are
duly elected and qualified.  Directors are elected by a plurality of
the votes present in person or represented by proxy and entitled  to
vote at the meeting.

Nominees to Board of Directors
    Name         Director    Age        Name              Director     Age
                  Since                                     Since
                                                                
Ralph S. Lobdell   1994      54     Alfred Alberts           1997      66
Stewart Carrell    1994      64     John P. McAlister,III    1994      49
Gary Meredith      1996      63     Ferid Murad              1996      61


     Ralph  S.  Lobdell   has served as Chairman  of  the  Board  of
Directors of the Company since June 1994.  Mr. Lobdell received  his
Bachelor  of Science degree from the U.S. Naval Academy in 1965  and
his  Master  of Business Administration from Stanford University  in
1972.   Mr.  Lobdell worked for First Chicago Corporation from  1972
through  1977, initially on the parent company staff  and  then  its
venture  capital subsidiaries.  In 1977, Mr. Lobdell  joined  Abbott
Laboratories in Chicago in Corporate Planning and Development.   Mr.
Lobdell  worked for the Harbour Group, a St. Louis based  investment
company, from 1979 to 1991 and was appointed President in 1987.   He
served  on  the  Board of Directors of virtually  all  of  Harbour's
portfolio companies acquired during his tenure.

     Alfred Alberts  was named a Director of the Company in February
1997.  Mr. Alberts is currently serving on the Board of Directors of
Inflazyme  Pharmaceuticals, Ltd., Vancouver,  and  is  a  scientific
consultant to several major pharmaceutical companies.  He served  as
the Vice President of Biochemistry and Natural Product Discovery  at
Merck  Research Laboratories prior to his retirement in 1995.  Prior
to  joining  Merck, Mr. Alberts was a member of the faculty  of  the
Department of Biochemistry at Washington University, St. Louis.  Mr.
Alberts has co-authored six patents and received several prestigious
awards  including the Thomas Alva Edison Award, the Inventor of  the
Year Award as well as an Honorary Doctor of Science degree from  the
University of Maryland.

      Stewart Carrell  has been a Director of the Company since  May
1994.  He also serves as Chairman of the Board of Directors of Evans
&   Sutherland   Computer  Corporation  and   of   Seattle   Silicon
Corporation.   Between 1984 and 1994, Mr. Carrell was  Chairman  and
Chief Executive Officer of several companies through his association
with the investment banking and venture capital firm of Hambrecht  &
Quist.   Prior  to 1984, Mr. Carrell was employed for  25  years  by
Texas  Instruments in various capacities, the most recent  of  which
was  Executive  Vice President.  Mr. Carrell holds an  undergraduate
degree from Southern Methodist University and a Masters degree  from
Stanford University.

      Dr.  John  P.  McAlister, III  has served as  Chief  Executive
Officer  and  Director since May 1994.  Dr. McAlister  obtained  his
B.S.  in Chemistry from Tarleton State College in 1971 and his Ph.D.
in  Biochemistry  and X-Ray Crystallography from the  University  of
Wisconsin,   Madison,  in  1978.   After  a  two-year  post-doctoral
appointment, Dr. McAlister joined the staff of the Computer  Systems
Laboratory  at Washington University, St. Louis, in 1980,  where  he
served   first   as  Associate  Director  of  the   MMS-X   National
Collaborative  Research Program and then as  Research  Associate  in
Computer  Science.  Dr. McAlister began working for Tripos  in  1982
under  contract  to  supervise software  development  for  molecular
graphics  applications.  In 1984, he joined Tripos  as  Director  of
Software Research and Development.  In 1987, Dr. McAlister was named
Vice  President, Research and Development, and in 1988 was  promoted
to President.

      Gary  Meredith  was named a Director of the Company in January
1996.  He currently serves as Senior Vice President and Secretary of
Evans  & Sutherland Computer Corporation ("E&S").  Mr. Meredith  has
been  with  E&S for twenty years where he has held several positions
including  Assistant to the President, VP-Administration, President-
Interactive  Systems Division, VP-Development, and  Chief  Financial
Officer.   Prior  to  joining E&S, he was  President  of   Interwest
General  Corporation and Windsor Industries.  Mr. Meredith also  was
Chairman and President of Reid-Meredith, Inc., a company he  founded
in  1962.  Mr. Meredith received his B.S. degree from Brigham  Young
University.   In addition to his position on the Board of  Directors
of  Tripos, Mr. Meredith is a Director of Blue Cross/Blue Shield  of
Utah.
                    
      Dr.  Ferid  Murad   was named a Director  of  the  Company  in
November  1996.  Dr. Murad received his M.D. and Ph.D. from  Western
Reserve  University.   Dr.  Murad is the former  Vice  President  of
Pharmaceutical Research and Development at Abbott Laboratories,  and
formerly, the President and CEO of Molecular Geriatrics Corporation,
a  bio-pharmaceutical  company.  Dr. Murad  has  held  a  number  of
notable  positions  during  his career  including  Chairman  of  the
Department of Medicine at Stanford University, Chief of Medicine  at
Palo Alto Veterans Administration Hospital, and Director of Clinical
Research  at  the  University of Virginia School of  Medicine.   Dr.
Murad  was  the  1996  recipient of the  prestigious  Albert  Lasker
Medical  Research award and is a member of the National  Academy  of
Science.   He is currently Professor and Chairman of the  Department
of  Integrative Biology and Pharmacology at the University of  Texas
Medical School.

      There are no family relationships among executive officers  or
directors  of  the Company.  No related party transactions  occurred
between the Company and any of the directors or their affiliates.


Board Meetings and Committees

      During  the fiscal year ended December 31, 1997, the Board  of
Directors of the Company held a total of ten (10) meetings.   During
this  period, a quorum of directors attended or participated in  all
of  (i)  the  meetings  of the Board that were  held  and  (ii)  the
meetings  held  by all committees of the Board of  which  they  were
members.

      The  Company has an Audit Committee, a Compensation Committee,
an  Executive  Committee, and a Technical Review  Committee  of  the
Board  of  Directors.  There is no nominating committee or committee
performing the functions of such committee.

       The  Audit  Committee  meets  with  the  Company's  financial
management  and its independent accountants at various times  during
each  year and reviews internal control conditions, audit plans  and
results,   and  financial  reporting  procedures.   This  Committee,
consisting  of Stewart Carrell, Ralph Lobdell, Alfred Alberts,  Gary
Meredith and Ferid Murad, held two (2) meetings during fiscal 1997.

      The  Compensation Committee reviews and approves the Company's
compensation   arrangements   for   management.    This   Committee,
consisting  of Ralph Lobdell, Alfred Alberts, Stewart Carrell,  Gary
Meredith and Ferid Murad, held two (2) meetings during fiscal 1997.

      The  Executive  Committee receives investment  proposals  from
within  and  without  the  Company and decides  whether  they  merit
consideration.  This Committee, consisting of Ralph Lobdell,  Alfred
Alberts,  Stewart Carrell, Gary Meredith and Ferid Murad, held  four
(4) meetings during fiscal 1997.

      The  Technical  Review  Committee  reviews  and  approves  the
mechanisms  by  which scientific and software development  decisions
are  made  by  the  Company.   This Committee,  consisting  of  John
McAlister,  Alfred Alberts, Ferid Murad  and several key  employees,
did not meet during fiscal 1997.


Director Remuneration

      Non-employee members of the Board, except for Mr. Lobdell, are
each paid an annual retainer of $10,000, and are reimbursed for  all
out-of-pocket costs incurred in connection with their attendance  at
all  Board  meetings and applicable committee meetings.  The  annual
retainer  is  paid quarterly in the form of 50% cash and  50%  stock
valued  at  the  then market rate.  Employee members  of  the  Board
receive no additional compensation for their service on the Board.

     Under the Tripos, Inc. 1994 Director Option Plan, an individual
who first becomes a non-employee member of the Board will receive an
automatic  option  grant for 10,000 shares of the  Company's  Common
Stock  upon commencement of Board service, and each individual  with
six or more months of Board service will receive an automatic option
grant  for  an  additional 2,500 shares on January 1 of  each  year.
Options  issued  under  the Tripos, Inc. 1994 Director  Option  Plan
become  exercisable at a rate of twenty-five percent  (25%)  of  the
shares  under  such option on each anniversary of the grant  of  the
option.  There are currently 300,000 shares reserved for issuance of
options  under  the  1994 Director Option  Plan,  as  amended.   The
exercise  price  for  the options granted under  the  1994  Director
Option Plan is equal to the fair market value of the Common Stock as
of  the last trading day immediately prior to the date the option is
granted.   The  options  have a term of ten  years.   However,  each
option automatically terminates 90 days after the optionee ceases to
be  a  director  of the Company except by reason of  the  optionee's
death, disability, or employment by the Company or a subsidiary, and
terminates within twelve (12) months after the occurrence of one  of
these stated events.

     Dr. Ferid Murad, receives a $1,000 fee for his role as Chairman
of  the Technical Review Committee for every meeting he attends, and
is  reimbursed  for  all  out-of  pocket  costs  incurred  with  his
attendance at such meetings.

      Mr.  Ralph  Lobdell receives an annual retainer of $25,000  as
Chairman of the Board for the Company, in lieu of the $10,000 annual
retainer  received  by  other non-employee  Board  members,  and  is
reimbursed  for all out-of-pocket expenses related to attendance  at
meetings  of the Board of Directors.  Mr. Lobdell's annual  retainer
is  paid  quarterly in the form of 50% cash and 50% stock valued  at
the then market rate.

      No  other compensation is paid to the non-employee members  of
the Board with respect to service on the Board.

Recommendation of the Board of Directors

      The  Board of Directors recommends that the shareholders  vote
FOR the election of each of the above nominees.

                                  
                                  
                             PROPOSAL 2:
         AMENDMENT TO THE 1994 EMPLOYEE STOCK PURCHASE PLAN
                                  
      The Board of Directors of the Company adopted an amendment  to
the 1994 Employee Stock Purchase Plan (the "1994 ESP Plan") on March
17,  1998,  and  directed that the amendment  be  submitted  to  the
shareholders  of  the  Company for their approval.   At  the  Annual
Meeting, the shareholders are being asked to approve an amendment to
the  Company's  existing  1994  ESP Plan  to  increase  the  maximum
aggregate number of shares which may be purchased by employees under
the  Plan from one hundred fifty thousand (150,000) to three hundred
fifty thousand (350,000).

     The 1994 ESP Plan is intended to provide for the sale of Common
Shares  of  the  Company to its employees.  The Board  of  Directors
believes  that  it is in the best interests of the Company  and  its
shareholders to provide a means for the employees of the Company  to
align their interests with those of the shareholders they serve.

General.   The 1994 ESP Plan was adopted on May 9, 1994  and  became
effective upon such date.  The 1994 ESP Plan provides for the  grant
of options to purchase Common Stock to employees of the Company.

Administration.   The  1994  ESP Plan is  designed  to  work  as  an
incentive  performance plan.  Eligible employees may elect  to  have
funds  withheld  from their pay to be set aside for the  semi-annual
purchase of Common Shares of the Company.

Eligibility.  Only employees of the Company are eligible  under  the
1994  ESP  Plan.  Currently, ninety two (92) employees (60%  of  the
eligible employees) participate in the 1994 ESP Plan.

Terms  of  Options.   The  exercise  price  of  options  granted  to
participating  employees is equal to 85% of the lower  of  the  fair
market  value of Tripos Common Stock on the beginning  date  or  the
ending date of the semi-annual offering period (ending each June  30
and December 31).  Employees may enroll in the Plan semi-annually on
January  1  or July 1.  Options granted to each employee consist  of
overlapping  twenty-four  month offering periods  within  which  the
employee  may continue to purchase shares at their enrollment  price
as long as it remains lower than the fair market value at the end of
each succeeding offering period.  Employees may designate up to  10%
of  their pay to be withheld and deposited into a Plan account to be
used  toward  the  semi-annual purchase  of  Common  Shares  in  the
Company.

Adjustment Upon Changes in Capitalization.  In the event any  change
is  made  in the Company's capitalization, such as a stock split  or
stock  dividend,  which results in a greater  or  lesser  number  of
shares of Tripos Common Stock, appropriate adjustment shall be  made
in the option price and in the number of shares remaining in reserve
subject to the options.  In the event of the proposed dissolution or
liquidation  of the Company, to the extent that an option  or  right
has  not  been  previously exercised, it will terminate  immediately
prior to the consummation of such proposed action.  In the event  of
the  merger  or  sale  of substantially all of  the  assets  of  the
Company, all outstanding options shall be assumed or substituted  by
the   successor  corporation,  or  if  they  are  not   assumed   or
substituted,  the  Board  may shorten the offering  period  and  all
outstanding options will be automatically exercised on the  exercise
date  set  by  the Board of Directors unless the employee  withdraws
prior to that date.

Amendment  and  Termination.  The Board of Directors  may  amend  or
terminate the 1994 ESP Plan at any time.  However, no such action by
the  Board of Directors may unilaterally alter or impair any  option
previously  granted under the 1994 ESP Plan without the  consent  of
the optionee.  To the extent necessary to comply with Rule 16b-3  or
under  Section  423 of the Internal Revenue Code, the Company  shall
obtain shareholder approval in such a manner and to such a degree as
required.   In  any event, the 1994 ESP Plan will terminate  in  May
2004.

Federal Income Tax Implications.   No Federal income tax is due upon
the receipt of the grant by the employee of a grant of options under
the  1994 ESP Plan or upon exercise of an option to purchase  Common
Stock.  Upon disposition  of the underlying shares at a profit,  the
employee  will have ordinary income with respect to the 15% discount
and capital gain or ordinary income from any additional profit.  The
Company is not entitled to a deduction with respect to grants  under
the 1994 ESP Plan.

Reserve  -  Number of Shares Available.  One hundred fifty  thousand
shares  of Common Stock are currently reserved for issuance pursuant
to  the  1994 ESP Plan.  As of December 31, 1997, 106,553 shares  of
Common  Stock had been purchased and issued under the Plan.  Without
taking  into account this proposed amendment to increase the maximum
aggregate  number  of shares, 43,447 shares remained  available  for
future purchase as of December 31, 1997.  The amendment to the  1994
ESP  Plan  will  increase  the number  of  shares  of  Common  Stock
available for issuance pursuant to the 1994 ESP Plan from 150,000 to
350,000.

Recommendation of the Board of Directors

The Board of Directors recommends that the shareholders vote FOR the
amendment to the 1994 Employee Stock Purchase Plan.
                                  
                                  
                             PROPOSAL 3:
               AMENDMENT TO THE 1994 STOCK OPTION PLAN
                                  
      The Board of Directors of the Company adopted an amendment  to
the  1994 Stock Option Plan (the "1994 Plan") on March 17, 1998, and
directed that the amendment be submitted to the shareholders of  the
Company for their approval.  At the Annual Meeting, the shareholders
are  being  asked to approve an amendment to the Company's  existing
1994  Plan to increase the maximum aggregate number of shares  which
may be optioned and sold under the Plan from one million one hundred
thousand  (1,100,000)  to  one million two hundred  eighty  thousand
(1,280,000).

      The  1994  Plan is intended to provide additional compensation
and   incentive  to  key  employees  whose  present  and   potential
contributions are important to the continued success of the Company,
to  afford  such employees an opportunity to acquire  a  proprietary
interest  in  the Company and to enable the Company to  continue  to
attract and retain the best available talent.

General.   The  1994  Plan was adopted on May  9,  1994  and  became
effective upon such date.  The 1994 Plan provides for the  grant  of
nonstatutory and incentive stock options to employees of the Company
pursuant to a discretionary grant mechanism.

Administration.  The 1994 Plan is designed to work as  an  incentive
performance  plan.  Options are granted by the President,  with  the
approval  of  the Compensation Committee of the Board of  Directors,
typically annually or upon promotions of key individuals.

Eligibility.   Only  employees or consultants  to  the  Company  are
eligible under the 1994 Plan.  Currently, eighty five (85) employees
participate in the 1994 Plan.

Terms  of  Options.   The  exercise  price  of  options  granted  to
employees must be 100% of the fair market value of the Tripos Common
Stock on the date of the grant unless the employee owns Common Stock
representing  more than 10% of the voting power of  all  classes  of
stock  in  the Company, any parent or subsidiary, in which case  the
exercise price may be no less than 110% of the fair market value  of
the  Common  Stock on the date of the grant.  The consideration  for
exercising  options granted to employees may only consist  of  cash,
check,  previously owned shares of Tripos Common Stock  or  cashless
exercise.   Options granted to the employees have a  ten  year  term
unless  the  optionee owns stock representing more than 10%  of  the
voting  power of all classes of stock in the Company, any parent  or
subsidiary,  in  which  case the term may  not  exceed  five  years.
Options  granted to the employees vest at the rate  of  25%  on  the
first anniversary of the grant and 1/48th per month for the next  36
months.  Outstanding options will expire on the earlier of ten years
from  the date of grant or 90 days after the employee receiving  the
grant ceases to be employed by the Company.

Adjustment Upon Changes in Capitalization.  In the event any  change
is  made  in the Company's capitalization, such as a stock split  or
stock  dividend,  which results in a greater  or  lesser  number  of
shares of Tripos Common Stock, appropriate adjustment shall be  made
in  the  option  price and in the number of shares  subject  to  the
options.  In the event of the proposed dissolution or liquidation of
the  Company,  to the extent that an option or right  has  not  been
previously  exercised, it will terminate immediately  prior  to  the
consummation of such proposed action.  In the event of the merger or
sale  of  substantially  all  of the  assets  of  the  Company,  all
outstanding options shall be assumed or substituted by the successor
corporation, or if they are not assumed or substituted,  they  shall
become  fully  vested  unless  the  Board  of  Directors  determines
otherwise.

Amendment  and  Termination.  The Board of Directors may  amend  the
1994  Plan at any time or may terminate it without approval  of  the
shareholders.  However, no such action by the Board of Directors may
unilaterally alter or impair any option previously granted under the
1994  Plan  without the consent of the optionee.  In any event,  the
1994 Plan will terminate in May 2004.

Federal Income Tax Implications.  All options granted under the 1994
Plan are granted at the market price on the date of the grant.  As a
result,  no Federal income tax is due upon the receipt of the  grant
by  the employee.  Federal taxes will apply at the time the employee
recognizes  a  gain  from the exercise and sale  of  the  underlying
shares.   The  Company may be entitled to a deduction equal  to  the
amount of taxable gain recognized by the optionee.

Reserve  -  Number  of  Shares Available.  One million  one  hundred
thousand  shares of Common Stock are currently reserved for issuance
pursuant  to  the  1994 Plan.  As of December 31, 1997,  options  to
purchase 895,207 shares of Common Stock had been granted, of  which,
options for 199,126 shares had been exercised.  Without taking  into
account  this  proposed amendment to increase the maximum  aggregate
number  of  shares,  204,793 shares remained  available  for  future
grants as of December 31, 1997.  The amendment to the 1994 Plan will
increase the number of shares of Common Stock available for issuance
pursuant to the 1994 Plan from 1,100,000 to 1,280,000.

Recommendation of the Board of Directors

The Board of Directors recommends that the shareholders vote FOR the
amendment  to  the 1994 Stock Option Plan. As detailed  in  Chairman
Ralph  Lobdell's introductory letter to shareholders, the  Board  of
Directors  has  resolved that, upon approval of this proposal,  they
will  reduce  the number of shares reserved under the 1994  Director
Stock  Option Plan and the 1996 Director Compensation Plan to offset
this increase in the 1994 Stock Option Plan reserve.
                                  
                                  
                       OWNERSHIP OF SECURITIES

     The following table sets forth, as of the Record Date, the name
of  each person who owns of record or is known by the Company to own
beneficially more than 5% of the outstanding shares of Common Stock,
the  number of shares owned by all directors, the executive officers
named  in  the  Summary  Compensation Table  (the  "Named  Executive
Officers") and all directors and executive officers as a group,  and
the  percentage of the outstanding shares represented thereby.   The
Company  believes that each of the directors and executive  officers
has  sole  voting  and investment power over such shares  of  Common
Stock.

Holders of More than 5%
                                 Amount and        
                                  Nature of            (1)
Name and Address of              Beneficial        Percent of
Beneficial Owner                  Ownership           Class
                                                        
J.P. Morgan & Co., Inc.          305,300 (2)          9.6%
60 Wall Street                   360,502 (3)
New York, New York 10260

State of Wisconsin Investment    278,334 (2)          8.8%
Board                            278,334 (3)
P.O. Box 7842
Madison, Wisconsin  53707

Vanguard/PRIMECAP Fund, Inc.     100,000(2)           3.1%
P.O. Box 2600                    100,000(3)
Valley Forge, Pennsylvania
19482

FMR Corporation                  76,600 (2)           2.4%
82 Devonshire                    120,700 (3)            
Boston, Massachusetts 02109
                                                        

Directors and Named Executive Officers:

                                 Amount and             
                                  Nature of            (1)
Name of Beneficial Owner         Beneficial         Percent of
                                  Ownership           Class
                                                        
Ralph S. Lobdell                   48,775             1.5%
Alfred Alberts                      2,770               *
Stewart Carrell                    24,426               *
Gary Meredith                      16,301               *
John P. McAlister III             126,029             4.0%
Ferid Murad                         3,486               *
Martin Bohl                         8,230               *
Richard D. Cramer III              46,662             1.5%
W. Ward Davidson III               28,498               *
Martin Stuart                      13,570               *
                                                        
All directors and named                         
executive officers as
a group (10 persons)              318,747            10.0%
)

*   Less than one percent of the outstanding Common Stock.
(1)   Percentage  of  beneficial ownership  is  calculated  assuming
 3,178,959 shares of Common Stock were outstanding on April 3, 1998.
This  percentage also includes Common Stock of which such individual
or entity has the right to acquire beneficial ownership within sixty
days of April 3, 1998, including but not limited to the exercise  of
an   option;  however,  such  Common  Stock  shall  not  be   deemed
outstanding for the purpose of computing the percentage owned by any
other  individual or entity.  Such calculation is required  by  Rule
13d-3(d)(1)(i) under the Securities Exchange Act of 1934.

(2)   This  information is based on Schedules  13G  filed  with  the
Securities  and  Exchange  Commission (the  "SEC").   The  reporting
entity attests that they have sole voting and investment power  over
their reported shares of Common Stock.

(3)  This information is based on Schedules 13G filed with the  SEC.
The  reporting entity attests that they have sole dispositive  power
over their reported shares of Common Stock.
                                  
                                  
                             MANAGEMENT
                                  
Set forth below is certain information with respect to additional
executive officers and key employees of the Company not listed in
"Election of Directors":

     Name               Age       Title

Martin Bohl              55   Vice President, European Software Operations
Anthony L. Cooper        54   Managing Director, Tripos Receptor Research Ltd.
Richard D. Cramer, III   56   Vice President, Scientific Activities
W. Ward Davidson, III    57   Vice President, Sales
Robert C. Glen           44   Vice President, ADS Research US and Asia
Peter Hecht              35   Vice President, ADS Research Europe
Scott G. Hutton          37   Vice President and General Manager,
                                 Discovery Software
Colleen A. Martin        37   Vice President, Chief Financial Officer,
                                 and Secretary
James H. Munn            45   European Controller
David E. Patterson       46   Senior Fellow
Gregory B. Smith         38   Fellow
Martin Stuart            41   Vice President and General Manager, ADS
Products
Paul L. Weber            39   Vice President, Software Consulting and
                                 Web Technology
Mary P. Woodward         52   Vice President, Strategic Development
John D. Yingling         41   U. S. Controller and Corporate Treasurer


      Dr. Martin Bohl obtained his training at the Friedrich Shiller
University of Jena in Germany, receiving the Diplom-Chemiker  degree
in  1974 and a Ph.D. in theoretical chemistry in 1979.  After  three
years  of  research and management at the Jenaer Glaswerk  Schott  &
Gen., Dr. Bohl joined the Academy of Sciences, Central Institute  of
Microbiology and Experimental Therapy in Jena.  During an eight-year
period,  Dr.  Bohl's  major  interests  included  structure-activity
relationships  of steroids.  Dr. Bohl joined Tripos in  1989  as  an
Application  and  Sales Support Scientist.  Other positions  he  has
held include: Manager of the Munich Sales Office, European Technical
Manager,  and General Manager for Central and Southern Europe.   Dr.
Bohl  was promoted to Vice President of European Software Operations
in October 1996.

      Dr.  Anthony  L. Cooper received his B.S. degree in  chemistry
from  Imperial College, London.  His Ph.D. project involved  studies
of  growth regulation in micro-organisms and was carried out in  the
Biochemistry Department of Imperial College.  At Glaxo Research Ltd,
he  managed part of the Natural Products Discovery group focused  on
the  identification  of  new  antibiotics.   At  Maybridge  Chemical
Company  Ltd. he set up and managed a biochemical research screening
group and also worked in synthetic chemistry programs.  In 1990, Dr.
Cooper  led  a  buy-out  of  this biochemical  section  and  founded
Receptor Research Ltd., of which he was Managing Director.   Initial
activities of this company involved receptor binding studies.  Later
research led to solid phase synthesis and other novel techniques for
the  production  of  drug-like  compounds.   Receptor  Research  was
acquired  by  Tripos  in November 1997 and renamed  Tripos  Receptor
Research  Ltd.  Dr. Cooper continues to direct the company  and  its
research programs.

      Dr.  Richard  D.  Cramer, III received his  A.B.  degree  from
Harvard  University in Chemistry and Physics in 1963, and his  Ph.D.
in  Physical  Organic Chemistry from the Massachusetts Institute  of
Technology in 1967.  Dr. Cramer worked for Polaroid Corporation from
1967 through 1969.  This was followed by a two year fellowship as  a
senior  member of the computer synthesis group at Harvard University
under direction of Dr. E. J. Corey.  Dr. Cramer joined Smith Kline &
French  Laboratories in 1971.  He was awarded a succession of titles
culminating  in Associate Director and Fellow, Medicinal  Chemistry.
Dr.  Cramer joined Tripos in 1983 as Vice President of New  Products
where  he  formulated  the  techniques  of  Comparative    Molecular
Field  Analysis (CoMFA), a patented software technology, at  Tripos.
Dr.  Cramer  was  named Vice President of Scientific  Activities  in
1988.  Dr. Cramer also founded and currently serves on the Board  of
Directors of STATS, Inc.

      Mr. W. Ward Davidson, III obtained his B.S. in Psychology from
the  University  of  Maryland in 1966, and  is  a  graduate  of  the
Management  Development  Program at  Northeastern  University.   Mr.
Davidson  was  a Systems Analyst and a Marketing Representative  for
IBM  from  1966 through 1972.  In 1972, he joined Digital  Equipment
Corporation, where he spent 12 years in Senior Sales Management  and
Operations Management.  From 1984 until 1992 Mr. Davidson  was  Vice
President,  Sales  for  Culler  Scientific,  a  mini-super  computer
manufacturer and Vice President, Sales for Wavefront Technologies, a
3-D  animation  software  company.  Mr. Davidson  joined  Tripos  in
January 1992, as Vice President of Sales.

      Dr.  Robert C. Glen  received his B.S. in Chemistry  from  the
University  of Paisley, Scotland in 1978 and his Ph.D. in  Chemistry
and  X-ray Crystallography from the University of Stirling in  1982.
Dr.  Glen  was  a  Senior Physical Chemist with  responsibility  for
computer-aided  molecular  design (CAMD) at  the  Wellcome  Research
Laboratories, in London, from 1982 to 1987.  After a short period at
ICI  Pharmaceuticals,  Dr. Glen returned to  Wellcome  as  a  Senior
Research  Scientist  responsible for CAMD, Protein  Crystallography,
measured  physico-chemical  properties  and  Quantitative  Structure
Activity  Relationships.  Dr. Glen has published over 70  scientific
papers  in drug discovery and holds a number of patents on drugs  in
the  clinic,  including Zomig (Zolmitriptan) for  the  treatment  of
migraine.  Dr. Glen joined Tripos in June 1995 as Senior Director of
Science.  In February 1996, Dr. Glen was promoted to Senior Director
of   Collaborative   Discovery  Services  and  to   Vice   President
Collaborative Discovery Services in August 1996.  He was named  Vice
President, ADS Research US and Asia in November 1997.

      Dr.  Peter  Hecht   received a degree in pharmacy from  Vienna
University,  Austria in 1987.  From 1987 to 1990 he  worked  at  the
Sandoz  Research  Institute in Vienna on the design  of  anti-fungal
compounds as part of his Ph.D. thesis, which he completed  in  1990.
From  1990 to 1992 he served as a post-doctoral researcher at Tripos
St.  Louis, funded initially by Sandoz then by the Erwin Schrodinger
scholarship.   From  1992 to 1995 he worked at the  Sandoz  Research
Institute  in  Vienna  as head of the local computational  chemistry
group.    In  1995,  he  joined  Tripos  in  Munich  and  has   been
establishing  the drug discovery efforts of Tripos as  well  as  the
consultancy  service business in Europe.  Dr. Hecht was promoted  to
Vice  President, ADS Research Europe, which includes  management  of
Tripos Receptor Research, in November 1997.

      Mr. Scott G. Hutton received his Bachelor of Science degree in
Chemistry  from the University of Missouri, Columbia, in 1984.   Mr.
Hutton worked as a Chemist at Monsanto Corporation from 1985 to 1988
and subsequently as a Technical Sales and Service Representative  at
the  Waters  Division of Millipore from 1988  to  1990.   He  joined
Tripos  as an Account Executive in 1990 and was promoted to Regional
Sales  Manager  in 1992.  In 1994, Mr. Hutton was named  U.S.  Sales
Manager and promoted to Vice President of Marketing in August  1996.
In  August  1997,  he  was promoted to Vice  President  and  General
Manager, Discovery Software.

      Ms.  Colleen A. Martin received her Bachelor of Science degree
in  Accounting from the University of Missouri, St. Louis,  in  1982
and  has  attended  Northwestern University's J.L. Kellogg  Graduate
School  of  Management Executive Programs.  Ms. Martin, a  Certified
Public  Accountant, worked on the audit staff for KPMG Peat  Marwick
LLP from 1982 through 1984 and worked for Continental Cablevision as
District  Controller  from 1984 through  1989.   Ms.  Martin  joined
Tripos in June 1989 as Controller and was promoted to Vice President
and Chief Financial Officer in April 1995.

     Mr. James H. Munn received both a B.A. in Biology in 1974 and a
M.S.  in  Accounting  in 1978 from California  State  University  at
Northridge.  Mr. Munn, a Certified Public Accountant, worked on  the
audit staff of Price Waterhouse from 1979 through 1980.  In 1980  he
joined  Tiger International as a Senior Financial Analyst  and  from
1983  through  1985 he was employed at Loral EOS  as  Supervisor  of
Accounting  Operations.  From 1985 to 1995, Mr.  Munn  held  various
financial  management positions at Radio Free Europe/Radio  Liberty,
Inc.,  Munich,  Germany.  Mr. Munn joined Tripos  in  July  1995  as
European Controller.

       Mr.   David  E.  Patterson   received  his  B.S.  in  Applied
Mathematics  and  Computer Science in 1974  and an M.S.  in  Systems
Science  in  1980  from Washington University  in  St.  Louis.   Mr.
Patterson worked as a Senior Research Scientist with the Center  for
Air  Pollution  Impact and Trend Analysis from  1976  until  joining
Tripos  in  1986.  His positions have included Product  Manager  for
QSAR and Senior Director of New Products prior to being promoted  to
Senior Fellow in March 1996.

      Mr.  Gregory  B. Smith received his B.S. and M.S.  degrees  in
Computer Science from Washington University in 1983. As part of  his
graduate  thesis,  he worked on the team which developed  the  first
SYBYL/VAX  prototype  under contract to Tripos.   Mr.  Smith  joined
Tripos  in  1986  as a member of the technical staff  where  he  was
responsible  for all graphics, systems, and quality control  related
activities.  Mr. Smith was named Director of New Technology in  1990
and  in  1994  was  named Vice President of Technology  and  Quality
Standards.  In 1996 he became a Fellow, with responsibility for  the
corporate databases.

      Dr.  Martin Stuart received his Bachelor of Science in Physics
and  Mathematics  from the Council for National Academic  Awards  in
London in 1982.  He was awarded a Ph.D. in the Physics of Thin Films
from the University College of North Wales in 1986.  Dr. Stuart is a
member  of  the  Institute of Physics and is a Chartered  Physicist.
Dr.  Stuart  joined  3M Company in 1974 and held several  scientific
positions,  and  ultimately, Senior Research  Scientist.   His  work
ranged from optimization of photographic development systems to  the
design of highly efficient drug delivery systems.  Dr. Stuart joined
Tripos  in  1987 to support its products in the United  Kingdom  and
Scandinavia.   He was promoted to Manager of Asia Pacific  Sales  in
1993.  Dr. Stuart was promoted to Vice President of the Americas and
Asia  Pacific  Sales  in February 1996.  In November  1997,  he  was
promoted to Vice President and General Manager, ADS Products.

      Dr. Paul L. Weber obtained his Bachelor of Science degrees  in
Chemistry and Honors Biology from the University of Illinois, Urbana
in  1981.   He  was  awarded  his Ph.D.  in  Biochemistry  from  the
University of Washington, Seattle in 1985.  Prior to joining Tripos,
Dr.  Weber  was  employed as Director of Scientific Applications  at
Hare Research, Inc. where he was involved with business development,
customer  support, sales and program documentation, development  and
debugging.   Dr.  Weber joined Tripos in January  1991  as  the  NMR
Project Manager.  In January 1995, Dr. Weber was promoted to  Senior
Director,  Product  Development  and  in  November  1995   to   Vice
President,  Product  Development. In 1997, Dr. Weber  initiated  the
Software  Consulting Services effort and was named  Vice  President,
Software Consulting Services & Web Technology.

      Ms.  Mary  P.  Woodward  obtained her  B.A.  in  English  from
Creighton  University  in  1967,  her  M.A.  in  English  from   the
University  of  Kansas  in  1969, and  has  taken  courses  in  high
technology,  international marketing and strategic alliance  offered
in  the  Berkeley, Stanford, and Northwestern J.L. Kellogg  Graduate
School  of  Management Executive Programs.  Since joining Tripos  in
1983,  Ms. Woodward has held a series of sales, legal, and marketing
administration positions, and is currently Vice President, Strategic
Development.

      Mr.  John D. Yingling  received his Bachelor of Science degree
in  Accounting from the University of Missouri, St. Louis,  in  1979
and  holds  certificates  as a Certified  Public  Accountant  and  a
Certified  Cash  Manager.  Mr. Yingling worked for Storz  Instrument
Company,  a micro-surgical instrument manufacturer, in a  series  of
accounting  positions  from 1979 to 1983 and for  Clayton  Brokerage
Company from 1983 to 1985.  This was followed by several accounting,
tax  and  treasury positions at Venture Stores, Inc.  from  1985  to
1995.  Mr. Yingling joined Tripos in May 1995 as U.S. Controller and
assumed the Corporate Treasurer responsibilities in March 1997.
                                  
                                  
           EXECUTIVE COMPENSATION AND RELATED INFORMATION
                                  
Summary of Cash and Certain Other Compensation

   The  following table sets forth the compensation  earned  by  the
Named Executive Officers for services rendered in all capacities  to
the Company and its subsidiaries for the fiscal years ended December
31, 1997, December 31, 1996, and December 31, 1995.

                     SUMMARY COMPENSATION TABLE
                                  
                                                   Long-Term             
                                Annual            Compensation           
                             Compensation            Awards
                                                         Securities  All Other
                                                  LTIP   Underlying Compensation
Name & Principal      Year   Salary    Bonus      Payouts  Options      
    Position                ($) (1)   ($) (2)     $ (3)    #  (4)       ($) (5)
                                                                        
John P. McAlister III 1997  170,833   100,000       -       12,000      10,902
   President and      1996  150,000      -        17,949    15,000       4,500
 Chief Executive      1995  150,000    20,000       -       15,000       3,465
         Officer  
                                                                        
W. Ward Davidson III  1997  120,000   101,580       -        5,000      30,757
  Vice President,     1996  120,000    76,881       -          -         8,750
           Sales      1995  124,932    70,068       -        2,500       7,723
                                                                        
Richard D. Cramer III 1997  115,000    38,669       -        5,000       2,588
  Vice President,     1996  115,000      -         4,711     5,000         -
      Scientific      1995  106,800     8,000       -        5,000       2,772
      Activities
                                                                        
Martin Stuart         1997#  89,167    85,222       -       22,500      15,027
  Vice President
  & General Manager,
  ADS Products
                                                                        
Martin Bohl           1997# 100,000    67,465       -        5,000      15,972
  Vice President,                                                     
  European Software
  Operations
                                                                        
Mark W. Schwartz      1997+  79,827    76,847       -          -        10,203
  Vice President,     1996  115,000    27,511       -        2,500       4,275
  Accelerated         1995  106,169    12,000       -       22,500       2,279
 Discovery Services

(1)  Includes salary deferred under the Company's 401(k) Plan.

(2)  Bonuses  earned were based on an allocation of a discretionary
bonus  pool.  There were no bonuses earned through the discretionary
bonus  pool in 1995.  Discretionary bonuses were accrued  in  fiscal
1994 and paid out in 1995.  Bonuses for fiscal years 1994, 1995  and
1996  for Mr. Davidson were earned based on commissions payable upon
the  Company's achievement of targeted revenue levels.  Bonuses  for
1996  and  1997  for Mr. Schwartz were earned based  on  commissions
payable  upon the Company's achievement of targeted revenue  levels.
The  1997 bonus paid to Mr. Cramer included a commission related  to
achieving targeted revenue goals in 1996.

(3)  LTIP  Payouts represent the gain on the sale of stock  options
exercised  under  the Evans & Sutherland Computer  Corporation  1985
Stock Option Plan for Key Employees granted and vested prior to  the
distribution  of the Company's stock by Evans & Sutherland  Computer
Corporation  ("E&S")  to  its shareholders  on  June  1,  1994,  the
("Distribution").   

(4)  The number of shares  underlying  option grants include options
granted to Tripos employees under  the  1994 Stock Option Plan.

(5)  "All Other Compensation" includes a matching contribution to the
  Company's 401(k) Plan.  It also includes a car allowance for   Mr.
  Davidson, Mr. Stuart and Mr. Bohl.

+  Mr. Schwartz's 1997 compensation reflects the period up until his
resignation from the Company on August 20, 1997.

#   Mr.  Stuart and Mr. Bohl became named executive officers of  the
Company during 1997.


Stock Options

   The following table contains information concerning the grant  of
stock options made to the Named Executive Officers in 1997.

                OPTION/SAR GRANTS IN LAST FISCAL YEAR
                                  
                                                                
                  Individual Grants                                        
                                % of                                 
                               Total                             Potential
                    Number    Options/                           Realizable 
                      of        SARs                           Value at Assumed
                  Securities Granted to                        Annual Rates of
                  Underlying  Employees  Exercise                Stock Price
                   Options/      in       Price                Appreciation for
                     SARs      Fiscal     Per     Expiration    Option Term     
     Name          Granted      Year    Share(2)    Date      5% (3)    10% (3)
                                                      
John P.                                                                 
  McAlister III    12,000(1)     6.8%    $12.50    7/29/07    $94,334   $239,061
                                            
Richard D.                                                              
  Cramer III        5,000(1)     2.8%    $12.50    7/29/07    $39,306   $99,609

W. Ward                                                                 
  Davidson III      5,000(1)     2.8%    $12.50    7/29/07    $39,306   $99,609
          
Martin Bohl         5,000(1)     2.8%    $12.50    7/29/07    $39,306   $99,609
                                                                        
Martin Stuart      10,000(1)     5.7%    $12.50    7/29/07    $78,612  $199,218
                   12,500(1)     7.1%    $13.69   12/22/07   $107,600  $272,679

                                                                        

(1)   The  options granted under the 1994 Stock Option  Plan  become
exercisable  as to 25% of the option shares on the first anniversary
of  the  grant date and 1/48th per month for three years thereafter.
The  options have a 10-year term, subject to earlier termination  in
the event of the optionee's cessation of service with the Company.

(2)   The  exercise  price of each option may be paid  in  cash,  in
shares  of Common Stock valued at fair market value on the  exercise
date  or  through a cashless exercise procedure involving a same-day
sale of the purchased shares.

(3)   The  five  percent (5%) and ten percent (10%)  assumed  annual
rates  of  compounded stock price appreciation are mandated  by  the
rules  of  the  Securities  and Exchange Commission.   There  is  no
assurance  provided to any executive officer or any other holder  of
the  Company's  securities that the actual stock price  appreciation
over the 10-year option term will be at the assumed 5% or 10% levels
or at any other defined level.


Option Exercises and Holdings

      The  following table provides information with respect to  the
Named  Executive Officers concerning unexercised options held as  of
the end of the 1997 fiscal year.

           AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                  AND FISCAL YEAR-END OPTION VALUES
                                  

                                                
                Shares           Number of Securities
               Acquired               Underlying          Value of Unexercised 
                  on     Value   Unexercised Options at   in-the-Money Options
  Name         Exercise Realized     Year-End 1997        at Fiscal Year-End  

                                               Un-                       Un-
                  #        $    Exercisable exercisable  Exercisable exercisable
John P.                                                                    
  McAlister III     0        $0  104,376     37,624     $1,003,916 (1) $261,585

Richard D.                                                                 
  Cramer III    9,900  $108,900   37,642     16,458       $348,749 (1) $108,839
 
W. Ward                                                                  
  Davidson III 26,161  $119,030    6,667     10,572        $63,232 (1)  $62,264
                                                                    
Martin Bohl         0        $0    6,417     13,583        $38,829 (1)  $40,421
                                                                   
Martin Stuart       0        $0    7,355     30,145        $56,360 (1)  $83,984
                                                                   
Mark W.        24,899  $102,811        0          0             $0 (1)       $0
  Schwartz
                                                                           

(1)  Based on the fair market value of Tripos Common shares on
December 31, 1997 ($14.625 per share).
                                  
                                  
                REPORT OF THE COMPENSATION COMMITTEE
                                  
      The  following is the Report of the Compensation Committee  of
the   Board   of   Directors  ("the  Committee"),   describing   the
compensation  policies  and rationale applicable  to  the  Company's
executive  officers with respect to the compensation  paid  to  such
executive  officers  for  the year ended  December  31,  1997.   The
Compensation Committee of the Board of Directors is responsible  for
setting  the  general compensation policies of  the  Company,  which
include  specific compensation levels for executive officers,  bonus
pools,  and  the 1994 Tripos Stock Option Plan.  These programs  and
the  Committee's compensation philosophy are designed to attract and
retain key executives by providing appropriate incentives linked  to
Company  performance. The Committee is composed of all  non-employee
Directors.

Compensation Philosophy

      The  Compensation Committee evaluates the performance  of  the
Chief  Executive Officer and other officers of Tripos annually based
upon  financial and non-financial performance goals which contribute
to the profitability of the Company.  The Compensation Committee has
approved  compensation policies that seek to enhance the linkage  of
compensation  to Company objectives and overall company performance.
The  executive  officers' compensation package is comprised  of  (i)
base  salary, (ii) annual incentive opportunity tied to  achievement
of  Operating Income and other goals, and (iii) long-term incentives
established  to align management with shareholders, in the  form  of
stock   options.  The  Chief  Executive  Officer  recommends  annual
increases for other executives for review and approval by the Board.

                 Base Salaries --   Individual salary increases  are
          likely to be based on a variety of factors including,  but
          not  limited to: competitive salary levels, individual job
          responsibilities,  results versus target  objectives,  and
          Company financial performance.

               Annual  Incentives -- Effective for fiscal  1995  and
          later  years,  the  Company's officers  were  eligible  to
          participate  in  an  annual incentive  compensation  plan.
          Annual  incentive targets are set as a percent  of  salary
          for  each  officer based on attainment of financial  goals
          including  Operating  Income  and  individual  performance
          goals.   Weighting  of goals varies by participant.   Over
          120%  of the Operating Income goal was achieved in  fiscal
          1996,  therefore a payout related to financial  goals  was
          made in early 1997.  No payout was made in 1996 for fiscal
          1995 nor in 1998 for fiscal 1997.

                Long-term Incentives -- The Company has adopted  the
          1994  Tripos Stock Option Plan to attract and  retain  the
          best  available  personnel  for positions  of  substantial
          responsibility,   to  provide  additional   incentive   to
          employees,  and  to promote the success of  the  Company's
          business.  Awards under the 1994 Tripos Stock Option  Plan
          are  designed  to give the recipient a significant  equity
          stake  in  the  Company and thereby  closely  align  their
          interests  with those of the Company's shareholders.    In
          fiscal  year  1994, the Board and Committee granted  stock
          options  to  officers and other employees under  the  1994
          Tripos Stock Option Plan subsequent to the distribution of
          the   Company's  stock  by  Evans  &  Sutherland  Computer
          Corporation ("E&S") to its shareholders on June  1,  1994,
          the   ("Distribution").  The  Committee  has   established
          certain  general  guidelines in making  option  grants  to
          executive officers in an attempt to target a fixed  number
          of  unvested  option  shares based upon  the  individual's
          position with the Company and his or her existing holdings
          of unvested options.  The number of shares granted to each
          executive officer in fiscal years 1997, 1996 and 1995  was
          based  upon the officer's tenure, level of responsibility,
          and  relative  position  in  the  Company.   However,  the
          Committee does not adhere strictly to these guidelines and
          will  occasionally vary the size of the option grant  made
          to each executive officer as circumstances warrant.


Chief Executive Officer Compensation

     The  Chairman  and other members of the Compensation  Committee
meet  semi-annually  with  Dr. McAlister  to  discuss  his  personal
performance during the fiscal year.  The Committee's objective is to
have  Dr. McAlister's base salary keep pace with the salaries  being
paid  to similarly situated CEOs in the software and high technology
industries,  and reflect individual performance and  achievement  of
Tripos  corporate  goals.  Dr. McAlister's base salary  is  reviewed
annually  by  the Compensation Committee based on these  discussions
and other criteria mentioned above.

      Notwithstanding anything to the contrary set forth in  any  of
the  Company's previous filing under the Securities Exchange Act  of
1934  that  might incorporate future filings, including  this  Proxy
Statement,  in  whole  or  in part, the  foregoing  report  and  the
Performance  Graph  which  follows  shall  not  be  deemed   to   be
incorporated by reference into any such filing.

          Compensation Committee
          Mr. Ralph S. Lobdell, Chairman
          Mr. Stewart Carrell
          Mr. Gary Meredith
          Dr. Ferid Murad
          Mr. Alfred Alberts



                  COMPARISON OF SHAREHOLDER RETURN
                                  
        Indexed Comparison of Total Return since Distribution
        Total Return Index for the NASDAQ National Market and
          Total Return for NASDAQ Pharmaceutical Companies
                                  
                                  
           Performance graph showing data from chart below


                  6/1/94   12/31/94   12/31/95   12/31/96  12/31/97

NASDAQ            100.00    103.12     145.83     179.39    220.22        
Pharmaceuticals   100.00     97.46     178.29     178.81    184.77
Tripos, Inc.      100.00     86.36     154.55     213.64    265.91
                                  

Note:      Assumes $100 invested on 6/1/94 in the Company, the total
return  index  for the NASDAQ National Market and the  total  return
index for NASDAQ Pharmaceutical Companies.  Assumes reinvestment  of
dividends on a daily basis.

      The  graph covers the period from June 1, 1994, the  date  the
Company's distribution of Common Stock to holders of record  of  the
Common  Stock  of  E&S  commenced, through  the  fiscal  year  ended
December 31, 1997.  The graph assumes that $100 was invested on June
1, 1994 in the Company's Common Stock and in each index and that all
dividends were reinvested.  No cash dividends have been declared  on
the  Company's Common Stock.  Shareholder returns over the indicated
period  should  not  be considered indicative of future  shareholder
returns.



                            ANNUAL REPORT
                                  
      A copy of the Annual Report of the Company for the fiscal year
ended December 31, 1997 has been mailed concurrently with this Proxy
Statement to all shareholders entitled to notice of and to  vote  at
the  Annual  Meeting. The Company filed a Form 10-K  with  the  SEC.
Shareholders may obtain a copy of the Form 10-K without  charge,  by
writing  to  Colleen Martin/Corporate Secretary,  at  the  Company's
executive  offices  at 1699 South Hanley Road, St.  Louis,  Missouri
63144.

             SELECTION OF INDEPENDENT PUBLIC ACCOUNTANTS
                                  
       Ernst  & Young LLP, independent certified public accountants,
has been selected by the Board of Directors as the firm to audit the
accounts  and to report on the financial statements of  the  Company
for the current fiscal year ending December 31, 1998.  Neither Ernst
&  Young  LLP,  nor  any of its members has any financial  interest,
direct  or indirect, in the Company, nor has Ernst & Young LLP,  nor
any of its members ever been connected with the Company as promoter,
underwriter, voting trustee, director, officer or employee.   It  is
anticipated  that a representative of Ernst & Young LLP will  attend
the  meeting  and  shall  be  available to  respond  to  appropriate
questions.  It is not anticipated that the representative from Ernst
& Young LLP will make any statement or presentation.



                            OTHER MATTERS
                                  
      The  Board  of  Directors does not know of any matters  to  be
presented  at this Annual Meeting other than those set forth  herein
and in the Notice accompanying this Proxy Statement.

                                   TRIPOS, INC.


                                   Colleen A. Martin
                                   Corporate Secretary

                                   April 7, 1998
                                   St. Louis, Missouri



                                  
                            Tripos, Inc.
                                  
     THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
                                  
                                                  April 10, 1998
Dear Shareholder:

     The undersigned hereby appoints Colleen  A. Martin and John D.
Yingling as proxies, each with full power to appoint her/his
substitute, and hereby authorizes them to vote all the shares of
Common Stock of Tripos, Inc. held of record by the undersigned at the
annual meeting of shareholders to be held on May 7, 1998, at 1:00
p.m., local time, at the World Trade Center St. Louis, 121 S.
Meramec, 10th Floor, Clayton, Missouri, 63105, or at any adjournment
thereof.: (1) as hereinafter specified upon the proposals listed on
the reverse and as more particularly described in the Company's proxy
statement, receipt of which is hereby acknowledged; and (2) in their
discretion upon such other matters as may properly come before the
Annual Meeting of Shareholders.

     PLEASE DETACH AND MARK THE PROXY, SIGN IT ON THE REVERSE SIDE,
       AND  RETURN IT IN THE ENVELOPE PROVIDED BEFORE THE BEFORE  THE
MEETING



- ---------------------------------------------------------------------
                      (Detach Proxy Form Here)

                                  
   A VOTE FOR THE FOLLOWING PROPOSALS IS RECOMMENDED BY THE BOARD.

1. Election of Directors

      FOR ( ) all nominees listed below           WITHHOLD AUTHORITY  ( )
   (except as marked to the contrary below)       to vote for all
                                                  nominees listed below

  (INSTRUCTION: To withhold authority to vote for any individual
   nominee, strike a line through the nominee's name in the list below)

Ralph Lobdell, Alfred Alberts, Stewart Carrell, John McAlister,
             Gary Meredith,  Ferid Murad
                                  
2. To Amend the 1994 Employee Stock Purchase Plan to increase the
   number of shares reserved thereunder from 150,000 to 350,000 shares;
  
       FOR ( )         AGAINST  ( )         ABSTAIN  ( )

3. To amend the 1994 Stock Option Plan to increase the number  of
   shares reserved thereunder from 1,100,000 to 1,280,000 shares;
   
       FOR ( )         AGAINST  ( )         ABSTAIN  ( )

4. In their discretion, the proxies are authorized to vote on such
   other business as may properly come before this meeting.

This proxy, when properly executed, will be voted in the manner directed
herein by the undersigned shareholder.  IF NO DIRECTION IS MADE, THIS
PROXY WILL BE VOTED FOR PROPOSALS 1, 2 AND 3.

                                        
                                   Dated: _______________, 1998
                                           
                                           
                                   ______________________________
                                         Signature *
                                           
                                   ______________________________
                                    Signature, if held jointly *
                                     
                                   *Please sign exactly as name
                                   appears on this form.  When 
                                   signing as attorney, executor,
                                   administrator, trustee, or
                                   guardian, please give full title
                                   as such.  If a corporation, please
                                   sign in full corporate name by
                                   President or other authorized
                                   officer.  If a partnership,
                                   please sign in partnership
                                   name by authorized person.


 PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY PRIOR TO THE MEETING.
- ---------------------------------------------------------------------
                      (Detach Proxy Form Here)




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