TRIPOS INC
SC 13G, 2000-02-16
PREPACKAGED SOFTWARE
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                  SCHEDULE 13G


                    Under the Securities Exchange Act of 1934
                              (Amendment No. ___)*

                                  Tripos, Inc.
                                (Name of Issuer)

                     Common Stock, par value $.01 per share
                            (Title of Class of Stock)

                                    896928108
                                 (CUSIP Number)

                                February 8, 2000
             (Date of Event Which Requires Filing of this Statement)


         Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

         / /  Rule 13d-1(b)
         /X/  Rule 13d-(c)
         / /  Rule 13d-1(d)

         *The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

         The information required in the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).



<PAGE>


                                  SCHEDULE 13G

CUSIP No.
- --------------------------------------------------------------------------------
1        NAMES OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         LION BIOSCIENCE AG
- --------------------------------------------------------------------------------
2        CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*               (a) / /
                                                                         (b) / /
- --------------------------------------------------------------------------------
3        SEC USE ONLY

- --------------------------------------------------------------------------------
4        CITIZENSHIP OR PLACE OF ORGANIZATION

         Germany
- --------------------------------------------------------------------------------
                                    5       SOLE VOTING POWER
         NUMBER OF

         SHARES                             409,091
                                    --------------------------------------------
                                    6       SHARED VOTING POWER
         BENEFICIALLY

         OWNED BY                           None
                                    --------------------------------------------
                                    7       SOLE DISPOSITIVE POWER
         EACH

         REPORTING                          409,091
                                    --------------------------------------------
                                    8       SHARED DISPOSITIVE POWER
         PERSON WITH

                                            None
- --------------------------------------------------------------------------------
9        AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                            409,091
- --------------------------------------------------------------------------------
10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
         CERTAIN SHARES* / /

- --------------------------------------------------------------------------------
11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

         10.8%
- --------------------------------------------------------------------------------
12       TYPE OF REPORTING PERSON*

         CO
- --------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

                                       2
<PAGE>


Item 1(a)         Name of Issuer:

                  Tripos, Inc.

Item 1(b)         Address of Issuer's Principal Executive Offices:

                  1699 South Hanley Road
                  St. Louis, Missouri 63144

Item 2(a)         Name of Person Filing:

                  LION Bioscience AG

Item 2(b)         Address of Principal Business Office

                  Waldhofer Strasse 98
                  D-69123 Heidelberg
                  Germany

Item 2(c)         Citizenship:

                  LION Bioscience AG is a German stock corporation.

Item 2(d)         Title of Class of Securities:

                  Common Stock, par value $.01 per share

Item 2(e)         CUSIP Number:

                  896928108

Item 3.           If this statement is filed pursuant to 240.13d-1(b) or
                  240.13d-2(b) or (c), check whether the person filing is a:

                  (a) [ ]  Broker or dealer registered under section 15 of the
Act (15 U.S.C. 78o).

                  (b) [ ]  Bank as defined in section 3(a)(6) of the Act
(15 U.S.C. 78c).

                  (c) [ ]  Insurance company as defined in section 3(a)(19) of
the Act (15 U.S.C. 78c).

                  (d) [ ]  Investment company registered under section 8 of the
Investment Company Act of 1940 (15 U.S.C. 80a-8).

                  (e) [ ]  An investment adviser in accordance with
240.13d-1(b)(1)(ii)(E);

                  (f) [ ]  An employee benefit plan or endowment fund in
accordance with 240.13d-1(b)(1)(ii)(F);

                  (g) [ ]  A parent holding company or control person in
accordance with 240.13d-1(b)(1)(ii)(G);

                                       3
<PAGE>

                  (h) [ ]  A savings association as defined in Section 3(b) of
the Federal Deposit Insurance Act (12 U.S.C. 1813);

                  (i) [ ] A church plan that is excluded from the definition of
an investment company under section 3(c)(14) of the Investment Company Act of
1940 (15 U.S.C. 80a-3);

                  (j) [ ]  Group, in accordance with 240.13d-1(b)(1)(ii)(J).

                  If this statement is filed pursuant to 240.13d-1(c), check
this box. [ ]

Item 4.           Ownership:

                  Amount Beneficially Owned:  409,091

                  Percent of Class:  10.8%

                  Number of shares as to such persons has:

                    (i)    sole power to vote or to direct the vote:  409,091
                    (ii)   shared power to vote or to direct the vote:  none
                    (iii)  sole power to dispose or to direct the disposition
                           of:  409,091
                    (iv)   shared power to dispose or to direct the disposition
                           of:  none

Item 5.           Ownership of Five Percent or Less of a Class:

                  Not applicable

Item 6.           Ownership of More Than Five Percent on Behalf of Another
                  Person:

                  Not applicable

Item 7.           Identification and Classification of the Subsidiary Which
                  Acquired the Security Being Reported on by the Parent Holding
                  Company:

                  Not applicable

Item 8.           Identification and Classification of Member of the Group:

                  Not applicable

Item 9.           Notice of Dissolution of Group:

                  Not applicable

                                       4
<PAGE>

Item 10.          Certification:

         By signing below I certify that, to the best of my knowledge and
         belief, the securities referred to above were not acquired and are not
         held for the purpose of or with the effect of changing or influencing
         the control of the issuer of the securities and were not acquired and
         are not held in connection with or as a participant in any transaction
         having such purpose or effect.

                                       5

<PAGE>


                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated February 15, 1999


                    LION BIOSCIENCE AG


                    By: /s/ Friedrich von Bohlen     /s/ Klaus Sprockamp
                        ------------------------     ------------------------
                        Chief Executive Officer      Chief Financial Officer


Attention:        Intentional misstatements or omissions of fact constitute
                  Federal criminal violations.  (See 18 U.S.C. 1001)

                                       6



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