TRIPOS INC
8-K, 2000-02-11
PREPACKAGED SOFTWARE
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             SECURITIES EXCHANGE AND COMMISSION
                  WASHINGTON, D. C.  20549


                          FORM 8-K
                       CURRENT REPORT


           Pursuant to Section 13 or 15(d) of the
               Securities Exchange Act of 1934



                       February 9, 2000
                       ---------------
      Date of Report (Date of earliest event reported)



                        TRIPOS, INC.
                    ---------------------
   (Exact name of registrant as specified in its charter)




 Utah                     000-23666             43-1454986
- --------                -------------         --------------
(State or other         (Commission          (I.R.S. Employer
jurisdiction of          File Number)        Identification No.)
incorporation)


         1699 South Hanley Rd., St. Louis, MO 63144
       ----------------------------------------------
    (Address of principal executive offices and zip code)


                       (314) 647-1099
                       --------------
    (Registrant's telephone number, including area code)


ITEM 5.  OTHER EVENTS.

      On February  7, 2000,  Tripos, Inc. ("TRPS") announced
that  it  had  entered  into  an  agreement to  sell  four
hundred  nine thousand  and ninety-one  (409,091) shares  of
its  Series B Convertible Preferred Stock common stock at  a
price  of $22 per share to LION Bioscience AG. in a  private
placement.   The  shares  were  issued,  and   TRPS
received  gross  proceeds of $9.0 million,  on  February  9,
2000,  proceeds  of the transaction were $9  million.   The
shares  were  issued  in  a private  placement  exempt  from
registration  under  the Federal securities  laws.   Further
information  about  the transaction is contained  in a press
release filed  as Exhibit 99.1 to this Current  Report  on
Form 8-K.

ITEM 7.  FINANCIAL STATEMENTS AND EXHIBITS.

(c)      Exhibit Number     Exhibit

         99.1               Press Release dated February 7, 2000

     Pursuant to the requirements of the Securities Exchange
Act  of 1934, the registrant has duly caused this report  to
be signed on its behalf by the undersigned duly authorized.


                                   TRIPOS,  INC.



Dated:  February 11, 2000       By: /s/ Colleen A. Martin
                                -------------------------------
                                    Colleen A. Martin
                                    Chief Financial Officer





                                INDEX TO EXHIBITS


EXHIBIT NO.         DESCRIPTION
- -----------         ------------
99.1                Press Release dated February 7, 2000





Exhibit 99.1

FOR RELEASE FEBRUARY 7, 2000       FOR FURTHER INFORMATION
                                   Colleen A. Martin
                                   Chief Financial Officer
                                   (800)-323-2960 or (314)
                                   647-1099


    Tripos, Inc. Announces Strategic Alliance and Private
       Placement of Securities with LION Bioscience AG

St. Louis, MO - February 7, 2000 - Tripos Inc. (NASDAQ:TRPS)
today  announced  that it will issue 409,091  shares  of  5%
Series  B Convertible Preferred Stock to LION Bioscience  AG
for a purchase price of $22.00 per share or $9.0 million  in
the  aggregate.   This represents 10.8% of  the  outstanding
shares  of the company on an as-converted basis.  The Series
B  Convertible  Preferred Stock is convertible  into  common
stock  of  TRIPOS  on  a share-for-share  basis  subject  to
customary antidilution provisions, and is redeemable by  the
investor  in  February 2005.  LION's CEO, Dr. Friedrich  von
Bohlen  will  join Tripos' Board of Directors.  Tripos  will
use these proceeds for working capital and general corporate
purposes.

The  investment  by  LION is part of  a  strategic  alliance
between  LION  and  Tripos whose purpose  is  to  develop  a
unified  platform  for information management  in  the  Life
Sciences,  combining  bioinformatics,  cheminformatics,  and
data  analysis.   These activities will span  Europe,  North
America,  and  Asia.  LION and Tripos will announce  further
details of this alliance in a separate press release.

"In  a  very  short time, LION has proved  itself  to  be  a
powerful  force in the realm of bioinformatics.  Tripos  and
LION  have  been  working together in  development  of  this
alliance  for  the  past  18 months,"  stated  Dr.  John  P.
McAlister, president and CEO of Tripos.  "We have  a  common
vision   of   the   power  of  integrated  informatics   and
experimental   science   and   have   highly   complementary
technologies and areas of scientific expertise.  Together we
bring  a  powerful  process to the  customer  to  drive  the
effectiveness   and  efficiency  of  the   entire   research
enterprise," he concluded.

"We  at  LION  are  excited  to be  allied  with  Tripos  in
executing  the  joint  vision for a  unified  Life  Sciences
research platform," commented Dr. Friedrich von Bohlen,  CEO
of  LION.  "As recognized leaders in our respective  fields,
Tripos  and  LION  are uniquely positioned  to  provide  the
pharmaceutical   and   related  industries   with   powerful
solutions in their research activities."



About Tripos, Inc.:

Tripos  (www.tripos.com) is a leading provider of  discovery
research    software   and   services   to   pharmaceutical,
biotechnology,  and life sciences companies worldwide.   The
company  is  dedicated  to optimizing and  accelerating  the
discovery of new products in the pharmaceutical and  related
industries.     Tripos   offers   "chemically   intelligent"
discovery  software  tools  to  manage,  analyze  and  share
biological  and  chemical information;  systems  integration
services; diverse chemical libraries; and contract  research
for  the  discovery, synthesis and characterization  of  new
chemical compounds that are active in biological systems.

Tripos has an established customer base that includes all of
the   pharmaceutical,   science  and   major   biotechnology
companies throughout the world.  Headquartered in St. Louis,
MO, Tripos has sales offices on the East and West coasts  of
the  USA  and  operating subsidiaries in Milton  Keynes  and
Bude, UK; Paris, France; and Munich, Germany.

About LION Bioscience AG:

LION  Bioscience AG (www.lionbioscience.com)  is  a  leading
genomics and information technology company, pioneering  the
field  of  i-biologyTM for expediting Life Science  research.
Founded  in  1997, the company has more than 190  employees,
with headquarters in Heidelberg, Germany and subsidiaries in
Cambridge,  UK  and Cambridge, Mass.  The company  leverages
its   core  competencies  in  information  technologies  and
genomics  to  accelerate and improve the drug discovery  and
Life Science research efforts of its partners throughout the
pharmaceutical, agricultural and biotechnology industry.

To  date,  LION  AG  has established numerous  alliances  in
informatics and genomics with leading Life Science  research
companies,  including Aventis, Bayer, Boehringer  Ingelheim,
DEGUSSA and Pharmacia & Upjohn.

Except for the historical information contained herein,  the
matters  set forth in this press release are forward-looking
statements   within  the  meaning  of  the   "safe   harbor"
provisions  of the Private Securities Litigation Reform  Act
of  1995.   These forward-looking statements are subject  to
risks  and  uncertainties that may cause actual  results  to
differ  materially.  For a discussion of  factors  that  may
cause  results to differ, see Tripos' SEC reports, including
its Annual Report on Form 10K.




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