NORTHFIELD LABORATORIES INC /DE/
PRE 14A, 1999-08-20
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
                                  SCHEDULE 14A
                                 (RULE 14A-101)

                    INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION
          PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES
                     EXCHANGE ACT OF 1934 (AMENDMENT NO.  )


  Filed by the registrant [X]

  Filed by a party other than the registrant [ ]

  Check the appropriate box:

  [x] Preliminary proxy statement        [ ]  Confidential, for Use of the
                                              Commission Only
                                              (as permitted by Rule 14a-6(e)(2))

  [ ] Definitive proxy statement

  [ ] Definitive additional materials

  [ ] Soliciting material pursuant to Rule 14a-11(c) or Rule 14a-12

                          NORTHFIELD LABORATORIES INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)


- --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of filing fee (Check the appropriate box):

  [x] No fee required.

  [ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

    (1) Title of each class of securities to which transaction applies:


- --------------------------------------------------------------------------------

    (2) Aggregate number of securities to which transaction applies:


- --------------------------------------------------------------------------------

    (3) Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the filing
fee is calculated and state how it was determined):


- --------------------------------------------------------------------------------

    (4) Proposed maximum aggregate value of transaction:


- --------------------------------------------------------------------------------

    (5) Total fee paid:


- --------------------------------------------------------------------------------

  [ ] Fee paid previously with preliminary materials.


- --------------------------------------------------------------------------------

  [ ] Check box if any part of the fee is offset as provided by Exchange Act
Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously. Identify the previous filing by registration statement number, or
the form or schedule and the date of its filing.

    (1) Amount previously paid:


- --------------------------------------------------------------------------------

    (2) Form, schedule or registration statement no.:


- --------------------------------------------------------------------------------

    (3) Filing party:


- --------------------------------------------------------------------------------

    (4) Date filed:


- --------------------------------------------------------------------------------
<PAGE>   2

                                                                PRELIMINARY COPY


                          NORTHFIELD LABORATORIES INC.
                        1560 Sherman Avenue, Suite 1000
                         Evanston, Illinois 60201-4800
                                ---------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

                                   to be held
                              on October 28, 1999

                                ---------------

TO THE STOCKHOLDERS OF NORTHFIELD LABORATORIES INC:

  The Annual Meeting of the stockholders of Northfield Laboratories Inc.
(the "Company") will be held on Thursday, October 28, 1999, at 2:00. P.M.,
local time, at the Third Floor, 1560 Sherman Avenue, Evanston, Illinois
60201-4800, for the following purposes:

     1.   To elect six directors to hold office until the next Annual Meeting
          of the stockholders of the Company;

     2.   To approve the appointment of KPMG LLP as independent auditors of the
          Company to serve for the Company's 2000 fiscal year;

     3.   To approve a proposal to amend the Company's Restated Certificate of
          Incorporation to increase the number of authorized shares of the
          Company's Common Stock, par value $.01 per share, from 20,000,000 to
          30,000,000; and

     4.   To transact such other business as may properly come before the
          Annual Meeting.

  The Board of Directors has fixed the close of business on September 1, 1999
as the record date for determination of stockholders entitled to notice of and
to vote at the Annual Meeting or any adjournment or postponement thereof.

  Stockholders are requested to complete and sign the enclosed Proxy, which is
solicited by the Board of Directors, and promptly return it in the accompanying
envelope.

                                             By Order of the Board of Directors



                                             JACK J. KOGUT
                                             Secretary

Evanston, Illinois
September 17, 1999

   IT IS IMPORTANT THAT YOUR STOCK BE REPRESENTED AT THE ANNUAL MEETING
REGARDLESS OF THE NUMBER OF SHARES YOU HOLD. PLEASE COMPLETE, SIGN AND MAIL THE
ENCLOSED PROXY IN THE ACCOMPANYING ENVELOPE EVEN IF YOU INTEND TO BE PRESENT AT
THE ANNUAL MEETING. RETURNING THE PROXY WILL NOT LIMIT YOUR RIGHT TO VOTE IN
PERSON OR TO ATTEND THE ANNUAL MEETING, BUT WILL ENSURE YOUR REPRESENTATION IF
YOU CANNOT ATTEND. THE PROXY IS REVOCABLE AT ANY TIME PRIOR TO ITS USE.


                                       2
<PAGE>   3

                          NORTHFIELD LABORATORIES INC.

                                ----------------
                                PROXY STATEMENT
                                ----------------


   This document is being furnished to holders of the common stock of
Northfield Laboratories Inc. in connection with the solicitation of proxies for
use at Northfield's annual meeting of stockholders to be held on Thursday,
October 28, 1999, commencing at 2:00 P.M., local time, at the Third Floor, 1560
Sherman Avenue, Evanston, Illinois 60201-4800, and at any adjournment or
postponement thereof, for the purpose of considering and acting upon the
matters set forth in the accompanying Notice of Annual Meeting of Stockholders.

   This document is first being mailed to holders of common stock on or about
September 17, 1999.

   Our principal executive offices are located at 1560 Sherman Avenue, Suite
1000, Evanston, Illinois 60201-4800. Our telephone number is (847) 864-3500.

VOTING AND RECORD DATE

   Only holders of record of common stock as of the close of business on
September 1, 1999, the record date for the annual meeting, are entitled to
notice of and to vote at the annual meeting. As of September 1, 1999, there
were 14,239,875 shares of common stock outstanding and entitled to be voted at
the annual meeting.

QUORUM

   Each holder of record of shares who is entitled to vote may cast one vote
per share held on all matters properly submitted for the vote of the
stockholders at the annual meeting. The presence, in person or by proxy, of the
holders of a majority of the outstanding shares of common stock entitled to
vote at the annual meeting is necessary to constitute a quorum at the annual
meeting.

   If a stockholder withholds its vote for the election of directors or
abstains from voting on the other proposals to be considered at the annual
meeting, the shares owned by that stockholder will be considered to be present
at the annual meeting for purposes of establishing the presence or absence of a
quorum for the transaction of business. If a broker indicates on the form of
proxy that it does not have discretionary authority as to certain shares to
vote on the proposal to amend our Restated Certificate of Incorporation to
authorize additional shares of our common stock, those shares will be
considered to be present at the annual meeting for purposes of establishing the
presence or the absence of a quorum for the transaction of business.

REQUIRED VOTE

   The affirmative vote of a plurality of the votes cast at the annual meeting
will be required for the election of directors. Because directors are elected
by a plurality vote, withheld votes have no impact in the election of directors
once a quorum is established.

   The affirmative vote of a majority of the votes cast at the annual meeting
will be required to approve the proposal with respect to the appointment of
independent auditors. Abstentions will be considered as votes cast with respect
to this proposal and will have the same effect as a vote against the proposal.

   The affirmative vote of a majority of the outstanding shares of common stock
will be required to approve the proposal to amend our Restated Certificate of
Incorporation to authorize additional shares of our common stock. Because of
this requirement, abstentions and broker non-votes on this proposal will be
have the same effect as a vote against the proposal.

PROXIES

   All shares entitled to vote and represented by properly executed proxies
received, and not revoked, prior to the annual meeting will be voted at the
annual meeting in accordance with the instructions indicated on those proxies.
If no instructions are indicated on a

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<PAGE>   4
properly executed proxy, the shares represented by that proxy will be voted as
recommended by the Board of Directors.

   If any other matters are properly presented at the annual meeting for
consideration, including, among other things, consideration of a motion to
adjourn the annual meeting to another time or place, the persons named in the
enclosed form of proxy will have discretion to vote on those matters in
accordance with their best judgment to the same extent as the person signing
the proxy would be entitled to vote. It is not currently anticipated that any
other matters will be raised at the annual meeting.

   Any proxy given pursuant to this solicitation may be revoked by the person
giving it at any time before it is voted. A proxy may be revoked by filing with
Northfield's Corporate Secretary, at or before the taking of the vote at the
annual meeting, a written notice of revocation or a duly executed proxy, in
either case later dated than the prior proxy relating to the same shares. A
proxy may also be revoked by attending the annual meeting and voting in person,
although attendance at the annual meeting will not itself revoke a proxy. Any
written notice of revocation or subsequent proxy should be sent so as to be
delivered to Northfield Laboratories Inc., 1560 Sherman Avenue, Suite 1000,
Evanston, Illinois 60201-4800, Attention: Corporate Secretary, or hand
delivered to the Corporate Secretary, at or before the taking of the vote at
the annual meeting.

ANNUAL REPORT

   A copy of the our Annual Report on Form 10-K for our 1999 fiscal year,
including financial statements, has been sent simultaneously with this document
or has been previously provided to all stockholders entitled to vote at the
annual meeting.

RECOMMENDATIONS OF THE BOARD OF DIRECTORS

   The Board of Directors recommends a vote FOR the election of the nominees
for election as directors, FOR approval of the appointment of KPMG LLP as
independent auditors for Northfield's 2000 fiscal year and FOR the proposal to
amend Northfield's Restated Certificate of Incorporation to authorize
additional shares of our common stock.


                                       4
<PAGE>   5

                         ITEM 1. ELECTION OF DIRECTORS

   Directors elected at the annual meeting will hold office until the next
annual meeting or until their earlier resignation or removal. In the event any
of the nominees should become unavailable for election, the Board of Directors
may designate substitute nominees, in which event shares represented by all
proxies returned will be voted for the substitute nominees unless an indication
to the contrary is included on the proxies.

<TABLE>
<CAPTION>
                                         DIRECTOR
                                            OF
                                        NORTHFIELD                                         PRINCIPAL OCCUPATION AND
                  NAME                    SINCE                 OFFICE                        BUSINESS EXPERIENCE
- -----------------------------------     ----------     ------------------------     ----------------------------------------
<S>                                     <C>            <C>                          <C>
Richard E. DeWoskin................        1985        Chairman of the Board of     Mr. DeWoskin, age 51, is a founding
                                                       Directors and Chief          member of Northfield's scientific
                                                       Executive Officer            team and has served as Chairman of
                                                                                    Board of Directors and Chief Executive
                                                                                    Officer of Northfield since its
                                                                                    inception in 1985. Prior to 1985, Mr.
                                                                                    DeWoskin served as the Assistant
                                                                                    Director of Surgical Research and as a
                                                                                    business advisor to the Department of
                                                                                    Surgery at Michael Reese Hospital and
                                                                                    Medical Center in Chicago, Illinois. In
                                                                                    1979, Mr. DeWoskin founded and operated
                                                                                    Medalease, Inc., a medical billing
                                                                                    business based at Michael Reese. From
                                                                                    1973 to 1977, Mr. DeWoskin served as
                                                                                    the Assistant Administrator of Surgical
                                                                                    Research at the Hektoen Institute of
                                                                                    Cook County Hospital in Chicago,
                                                                                    Illinois. Mr. DeWoskin received his
                                                                                    B.S. degree from Roosevelt University.

Steven A. Gould, M.D...............        1993        President and Director       Dr. Gould, age 52, is a founding member
                                                                                    of Northfield's scientific team and has
                                                                                    served as President and a director of
                                                                                    Northfield since July 1993. Prior to
                                                                                    that time, Dr. Gould served as a
                                                                                    Consultant and Principal Investigator
                                                                                    for Northfield's clinical trials. From
                                                                                    1989 to 1993, Dr. Gould served as Chief
                                                                                    of the Department of Surgery of Michael
                                                                                    Reese. Since 1990, Dr. Gould has also
                                                                                    served as Professor of Surgery
                                                                                    (nonsalaried) at the University of
                                                                                    Illinois College of Medicine. From 1979
                                                                                    through 1989, Dr. Gould was Assistant
                                                                                    Professor and then Associate Professor
                                                                                    in the Department of Surgery at The
                                                                                    University of Chicago School of
                                                                                    Medicine. Dr. Gould has been involved
                                                                                    in development of national transfusion
                                                                                    policy through his participation in the
                                                                                    activities of the National Heart Lung
                                                                                    Blood Institute, the National Blood
                                                                                    Resource Education Panel, the
                                                                                    Department of Defense, the American
                                                                                    Association of Blood Banks, the
                                                                                    American College of Surgeons and The
                                                                                    American Red Cross. Dr. Gould received
                                                                                    his M.D. degree from the Boston
                                                                                    University School of Medicine in 1973.
</TABLE>


                                       5
<PAGE>   6

<TABLE>
<S>                                     <C>            <C>                          <C>
Gerald S. Moss, M.D................        1989        Director                     Dr. Moss, age 64, is a founding member
                                                                                    of Northfield's scientific team and has
                                                                                    served as a director of Northfield
                                                                                    since 1989. Since 1989, Dr. Moss has
                                                                                    been the Dean of the University of
                                                                                    Illinois College of Medicine. From 1977
                                                                                    until 1989, Dr. Moss was a Professor in
                                                                                    the Department of Surgery of The
                                                                                    University of Chicago School of
                                                                                    Medicine and Chairman of the Department
                                                                                    of Surgery of Michael Reese. Dr. Moss
                                                                                    has been involved in development of
                                                                                    national transfusion policy through his
                                                                                    participation in the activities of the
                                                                                    National Heart Lung Blood Institute,
                                                                                    the National Blood Resource Education
                                                                                    Panel, the Department of Defense, the
                                                                                    American Association of Blood Banks,
                                                                                    the American Blood Commission, the
                                                                                    American College of Surgeons and The
                                                                                    American Red Cross. Dr. Moss received
                                                                                    his M.D. degree from the Ohio State
                                                                                    University College of Medicine in 1960.



Bruce S. Chelberg..................        1989        Director                     Mr. Chelberg, age 65, has served as a
                                                                                    director of Northfield since 1989. Mr.
                                                                                    Chelberg has served since May 1992 as
                                                                                    the Chairman and Chief Executive
                                                                                    Officer of Whitman Corporation, a
                                                                                    principal stockholder in Northfield.
                                                                                    From 1982 to 1992, Mr. Chelberg served
                                                                                    in a number of executive positions with
                                                                                    Whitman Corporation. Mr. Chelberg is
                                                                                    also a director of Whitman Corporation,
                                                                                    First Midwest Bancorp, Inc., Snap-On
                                                                                    Tools Corp. and is a member of the
                                                                                    Illinois Bar Association. Mr. Chelberg
                                                                                    received his LLB degree from the
                                                                                    University Of Illinois College of Law
                                                                                    in 1958.
</TABLE>

                                       6
<PAGE>   7


<TABLE>
<S>                                     <C>            <C>                          <C>
Jack Olshansky.....................        1989        Director                     Mr. Olshansky, age 70, has served as a
                                                                                    director of Northfield since 1989. Mr.
                                                                                    Olshansky has since 1984 been a
                                                                                    founding general partner of Montgomery
                                                                                    Medical Ventures, L.P. From 1980 to
                                                                                    1983, Mr. Olshansky served as vice
                                                                                    president of the Medical Division of
                                                                                    Cutter Laboratories. Mr. Olshansky is
                                                                                    also a director of EndiCor, Inc.,
                                                                                    PrisMedical, Inc., Tandem and The
                                                                                    Trylon Corporation. Mr. Olshansky
                                                                                    received his B.A. degree from Brooklyn
                                                                                    College in 1950.

David A. Savner....................        1998        Director                     Mr. Savner, age 55, has served as a
                                                                                    director of Northfield since April
                                                                                    1998. Mr. Savner has since April 1998
                                                                                    been the Senior Vice President and
                                                                                    General Counsel of General Dynamics
                                                                                    Corporation. From 1987 to 1998, Mr.
                                                                                    Savner was a senior partner in the law
                                                                                    firm of Jenner & Block, Northfield's
                                                                                    principal legal counsel. Mr. Savner
                                                                                    received his J.D. degree from
                                                                                    Northwestern University Law School in
                                                                                    1968.
</TABLE>

COMMITTEES OF THE BOARD OF DIRECTORS

   We currently have two standing committees. The compensation committee, which
met once during the 1999 fiscal year, is composed of Messrs. DeWoskin
(Chairman), Chelberg and Olshansky. The compensation committee has the
authority, as delegated by the Board of Directors, to administer our executive
compensation plans and to determine the salaries and incentive compensation,
including the grant of stock options, to be received by our executive officers
and employees.

   The audit committee, which met once during the 1999 fiscal year, is composed
of Messrs. Chelberg (Chairman), Olshansky and Dr. Gould. The functions of the
audit committee include the review of the planning and results of our annual
audit, the adequacy of our internal accounting controls, and the auditing and
accounting principles and practices to be used in the preparation of our
financial statements.

MEETING ATTENDANCE

   During fiscal 1999, the Board of Directors met five times, and no incumbent
director attended fewer than 75 percent of the total number of meetings of the
Board of Directors and the committees of which he was a member, with the
exception of Mr. Chelberg, who attended three of the five meetings of the Board
of Directors.

COMPENSATION OF DIRECTORS

   We compensate outside directors for their participation at Board of
Directors meetings and at committee meetings of the Board of Directors at a
rate of $1,000 per meeting. Directors are also reimbursed for their expenses
for attending meetings of the Board of Directors and committees. Mr. Chelberg
has declined this compensation and reimbursement of expenses.

CERTAIN BUSINESS RELATIONSHIPS

  Our principal legal counsel is the firm of Jenner & Block, Chicago, Illinois.
Until April 1998, Mr. Savner was a senior partner at Jenner & Block.


                                       7
<PAGE>   8


                                   MANAGEMENT

EXECUTIVE OFFICERS

   The Board of Directors will elect our executive officers at its first
meeting following the annual meeting. Our executive officers are as follows:

<TABLE>
<CAPTION>
                NAME                                                       POSITION
- -----------------------------------------      --------------------------------------------------------------
<S>                                            <C>
Richard E. DeWoskin.......................     Chairman of the Board of Directors and Chief Executive Officer
Steven A. Gould, M.D......................     President
Jack J. Kogut.............................     Vice President -- Finance, Secretary and Treasurer
John D. Grove.............................     Vice President -- Operations
John A. Dybas, Jr.........................     Vice President -- Regulatory Affairs
Marc D. Doubleday.........................     Vice President -- Process Engineering
Robert L. McGinnis........................     Vice President -- Manufacturing Development
</TABLE>

   A biographical summary of the business experience of Mr. DeWoskin and Dr.
Gould is included under "Election of Directors."

   Mr. Kogut, age 52, has served as Vice President -- Finance since 1986. Mr.
Kogut has also served as Northfield's Secretary and Treasurer since January
1994. From 1982 to 1986, he was the Group Controller-Health Products for Sybron
Corporation and also served as President of Sybron Asia. Mr. Kogut received his
M.B.A. degree from Loyola University of Chicago in 1972.

   Mr. Grove, age 50, joined Northfield in July 1993 as Vice President --
Operations. From 1981 until joining Northfield, Mr. Grove served in various
managerial positions with the Nutrasweet Company. Most recently, Mr. Grove was
the Director of EQUAL Operations for Nutrasweet. Mr. Grove received his B.S.
degree from Purdue University in 1972.

   Mr. Dybas, age 61, has served as Vice President -- Regulatory Affairs since
January 1996. From 1989 to 1996, he served as Northfield's Director of
Regulatory Affairs. Prior to 1989, Mr. Dybas was a self-employed consultant and
spent two years as Director of Regulatory Affairs for the Pharmaceutical
Products Division of Abbott Laboratories, Inc. Mr. Dybas received his M.S.
degree from Syracuse University in 1963.

   Mr. Doubleday, age 40, has served as the Vice President -- Process
Engineering since December 1994. Prior to that time, he served as Northfield's
Plant Manager and Senior Process Engineer. Before joining Northfield in 1988,
Mr. Doubleday was employed in various capacities with Davy McKee, Millipore
Corporation and Abbott Laboratories, Inc. Mr. Doubleday received his M.M.
degree from Northwestern University in 1991.

   Mr. McGinnis, age 35, has served as the Vice President -- Manufacturing
Development since August 1997. From 1995 to 1997, Mr. McGinnis was a Project
Manager for Raytheon Engineering and Construction. Prior to 1995, Mr. McGinnis
was employed by the John Brown division of Trafalgar House as a Project Manager
and Engineer. Mr. McGinnis received his MBA degree from the University of
Chicago in 1995.

EXECUTIVE COMPENSATION

   The following table summarizes all compensation paid for our last three
completed fiscal years to our Chief Executive Officer and four other most
highly compensated executive officers.


                                       8
<PAGE>   9

                         SUMMARY OF COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                             LONG-TERM
                                                                            COMPENSATION
                                                 ANNUAL COMPENSATION           AWARDS
                                             ----------------------------   ------------

                                                             OTHER          SECURITIES
                                                             ANNUAL         UNDERLYING       ALL OTHER
NAME AND PRINCIPAL POSITION        YEAR(1)    SALARY      COMPENSATION(2)    OPTIONS(#)    COMPENSATION(3)
- ------------------------------     -------   --------     ---------------   ------------   ---------------
<S>                                <C>       <C>          <C>               <C>            <C>
Richard E. DeWoskin.............     1999     $255,022         $22,395          40,000              --
Chief Executive Officer              1998      244,213          20,666          20,000          $  706
                                     1997      232,278          20,204          55,000           1,413

Steven A. Gould, M.D...........      1999      270,546          25,594          30,000              --
President                            1998      259,079          23,800          15,000              --
                                     1997      246,418          17,681          45,000              --

Jack J. Kogut..................      1999      213,668          21,197          25,000              --
Vice President -- Finance            1998      204,611          20,481          15,000             578
                                     1997      194,612          18,691          35,000           1,156

John D. Grove..................      1999      162,559          11,749          10,000              --
Vice President -- Operations         1998      159,242          11,574           5,000              --
                                     1997      153,984          11,456          15,000              --

John A. Dybas, Jr..............      1999      162,989          13,961          10,000              --
Vice President  --                   1998      156,081          11,960          10,000              --
Regulatory Affairs                   1997      178,453          12,686          15,000              --
</TABLE>

- ----------------

  (1) Our fiscal year begins on June 1 and ends on May 31. Our 1999 fiscal
      year ended May 31, 1999.

  (2) The indicated amounts represent life insurance premiums paid by
      Northfield and contributions made by Northfield to the indicated
      executive officer's 401(k) plan account.

  (3) The indicated amounts represent the amortization of below market stock
      option grants.


                                       9


<PAGE>   10


   The following table sets forth all options granted to our Chief Executive
Officer and other named executive officers during our last completed fiscal
year.

                       OPTION GRANTS IN LAST FISCAL YEAR

<TABLE>
<CAPTION>
                                                                                              POTENTIAL
                                                                                          REALIZABLE VALUE
                                                                                          AT ASSUMED ANNUAL
                                                  PERCENT OF                               RATES OF STOCK
                                                 TOTAL OPTIONS                           PRICE APPRECIATION
                                NUMBER OF         GRANTED TO    EXERCISE                  FOR OPTION TERM(1)
                          SECURITIES UNDERLYING   EMPLOYEES IN   PRICE     EXPIRATION   --------------------
       NAME                  OPTIONS GRANTED      FISCAL YEAR    ($/SH)       DATE         5%         10%
- ------------------------  ---------------------  -------------  --------   ----------   --------    --------
<S>                       <C>                    <C>            <C>        <C>          <C>         <C>
Richard E. DeWoskin.....         40,000                30%       $10.81      4/07/09    $271,934    $689,134
Steven A. Gould, M.D....         30,000                22         10.81      4/07/09     203,951     516,851
Jack J. Kogut...........         25,000                19         10.81      4/07/09     169,959     430,709
John D. Grove...........         10,000                 7         10.81      4/07/09      67,984     172,284
John A. Dybas, Jr.......         10,000                 7         10.81      4/07/09      67,984     172,284
</TABLE>

- ----------

 (1)  The potential realizable value amounts shown illustrate the values that
      might be realized upon exercise immediately prior to the expiration of
      their term using five percent and ten percent appreciation rates as
      required to be used in this table by the Securities and Exchange
      Commission, compounded annually, and are not intended to forecast
      possible future appreciation, if any, of our stock price. Additionally,
      these values do not take into consideration the provisions of the options
      providing for nontransferability or termination of the options following
      termination of employment.

   The following table sets forth information regarding stock option exercises
by our Chief Executive Officer and other named executive officers and the
aggregate value as of May 31, 1999 of unexercised stock options held by these
individuals.

                AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                       AND FISCAL YEAR-END OPTION VALUES

<TABLE>
<CAPTION>
                                                         NUMBER OF SECURITIES
                                                              UNDERLYING              VALUE OF UNEXERCISED
                                                          UNEXERCISED OPTIONS         IN-THE-MONEY OPTIONS
                              SHARES       VALUE          AT FISCAL YEAR-END          AT FISCAL YEAR-END(1)
                           ACQUIRED ON    REALIZED     -------------------------    --------------------------
        NAME               EXERCISE(#)      ($)        EXERCISABLE/UNEXERCISABLE    EXERCISABLE/UNEXERCISABLE
- ------------------------   -----------    --------     -------------------------    --------------------------
<S>                        <C>            <C>          <C>          <C>             <C>         <C>
Richard E. DeWoskin.....        --            --          60,000         66,000       $ 68,915     $104,273
Steven A. Gould, M.D....        --            --          98,750         41,250         56,385       37,590
Jack J. Kogut...........    12,500        46,688          53,750         45,250        129,100       75,632
John D. Grove...........        --            --          47,250         13,750         52,893       12,530
John A. Dybas, Jr.......        --            --          23,500         17,500         52,893       12,530
</TABLE>

- ----------

  (1) These figures are based on a fair market value for our common stock at
      May 28, 1999 of $12.063 per share, the closing price of the common stock
      as reported by the Nasdaq National Market as of that date. May 28, 1999
      represents the last trading day in our 1999 fiscal year.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

   The compensation committee of the Board of Directors consists of Messrs.
DeWoskin (Chairman), Chelberg and Olshansky. Mr.


                                       10
<PAGE>   11


DeWoskin is the Chief Executive Officer of Northfield. Mr. DeWoskin did not
serve as a director of any other entity during our last completed fiscal year.
Mr. Chelberg is the Chairman and Chief Executive Officer of Whitman
Corporation. Mr. Olshansky is a founding general partner of Montgomery Medical
Ventures, L.P.

EMPLOYMENT AGREEMENTS

   We have employment agreements with Richard E. DeWoskin, our Chief Executive
Officer, Steven A. Gould, M.D., our President, and Jack J. Kogut, our Vice
President -- Finance, Secretary and Treasurer. These employment agreements
provide for terms expiring in December 2000. The annual salaries payable under
the employment agreements with Mr. DeWoskin, Dr. Gould and Mr. Kogut are
$262,309, $278,276 and $219,772, respectively. The employment agreements
provide that the salaries of the respective executive officers may be reviewed
annually by the Board of Directors and may be increased but not decreased from
the foregoing amounts. The employment agreements also provide for certain
payments following a termination of employment occurring after a change in
control of Northfield.

EMPLOYEE STOCK OPTION PLANS

   Our Restated Nonqualified Stock Option Plan lapsed on September 30, 1996.
Following termination of this plan, all options outstanding prior to plan
termination may be exercised in accordance with their terms. As of May 31,
1999, options to purchase a total of 128,000 shares of common stock at prices
between $6.38 and $15.19 per share were outstanding under this plan. These
options expire between 2000 and 2004, ten years after the date of grant.

   The Northfield Laboratories Inc. 1996 Stock Option Plan provides for the
granting of stock options to purchase up to 500,000 shares of common stock to
directors, officers, key employees and consultants. As of May 31, 1999, options
to purchase a total of 480,000 shares of common stock at prices between $9.56
and $13.38 were outstanding under the 1996 plan. These options expire between
2006 and 2009, ten years after the date of grant.

   The Northfield Laboratories Inc. 1999 Stock Option Plan was established
effective June 1, 1999. The 1999 Plan provides for the granting of stock
options to purchase up to 500,000 shares of common stock to directors,
officers, key employees and consultants. No options have been granted to date
under the 1999 plan.

STOCK OPTION PLAN FOR OUTSIDE DIRECTORS

   The Nonqualified Stock Option Plan for Outside Directors provides for the
granting of stock options to purchase up to 200,000 shares of common stock to
directors who are neither employees of nor consultants to Northfield and who
were not directors on June 1, 1994. As of May 31, 1999, options to purchase a
total of 15,000 shares of common stock at a price of $13.38 per share were
outstanding under this plan. These options expire in 2008.

EMPLOYEE BENEFIT PLANS

   We sponsor a defined contribution 401(k) savings plan covering each of our
employees satisfying certain minimum length of service requirements. We make
discretionary matching contributions to the accounts of plan participants in an
amount equal to 50 percent of each plan participant's before tax contribution,
subject to certain maximum contribution limitations. Our expenses incurred
under this plan for the years ended May 31, 1999, 1998 and 1997 were $118,167,
$98,567 and $99,781, respectively.

SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

   Section 16(a) of the Securities and Exchange Act of 1934 requires that our
directors, executive officers and persons who beneficially own more than 10% of
our common stock file with the Securities and Exchange Commission initial
reports of beneficial ownership of the common stock and reports of changes in
their beneficial ownership.

   To our knowledge, based solely upon a review of copies of reports furnished
to us and written representations that no other reports were required during
the fiscal year ended May 31, 1999, our officers, directors and greater than
10% beneficial owners complied during our last fiscal year with all applicable
Section 16(a) filing requirements.


                                       11
<PAGE>   12


COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

   This report of the compensation committee of the Board of Directors
discusses our executive compensation policies and the bases for the
compensation paid to the our Chief Executive Officer during our last completed
fiscal year.

COMPENSATION POLICY

   Our policy with respect to executive compensation has been designed to
compensate executive officers fairly and adequately in relation to their
responsibilities, capabilities and contributions to Northfield. We have also
sought to align the interests of senior management with those of our
stockholders with respect to long-term increases in the price of our stock. The
compensation committee considers it essential to our success that the
compensation paid to executive officers remain competitive with similar or
competitive companies in order to attract and retain the talented senior
management necessary to achieve our business objectives.

COMPONENTS OF COMPENSATION

   The components of compensation paid for our last completed fiscal year to
our executive officers consisted of base salary, gains from the exercise of
stock options and certain other benefits. Stock options to purchase a total of
115,000 shares of common stock were granted to our Chief Executive Officer and
other named executive officers during our most recent fiscal year.

   We have employment agreements which provide for specified annual salaries
with Richard E. DeWoskin, our Chief Executive Officer, Steven A. Gould, M.D.,
our President, and Jack J. Kogut, our Vice President -- Finance, Secretary and
Treasurer. See "Management -- Employment Agreements." The annual salaries
provided in these employment agreements were determined based principally on
the compensation levels for similar or competitive companies, including
companies in the pharmaceutical and biomedical industries, as well as the
levels of responsibility and experience of the individual executive.

   Under the Northfield Laboratories Inc. 1996 Stock Option Plan, options to
purchase shares of common stock, at the fair market price of the shares on the
date of grant, may be made to directors, officers, key employees and
consultants. The compensation committee determines the timing, pricing and
amount of option awards to provide recipients with the opportunity to share in
increases in the long-term stockholder value of Northfield in amounts which are
consistent with their responsibilities. Options granted under the 1996 plan
include time vesting provisions intended to provide an incentive for the
recipient to continue in the service of Northfield. There are no predetermined
performance milestones or award levels applicable to the pricing or amount of
options granted under the 1996 plan.

   The other benefits provided to our executive officers consist of enhanced
life and disability insurance coverage. Executive officers are also eligible
for coverage under our general medical and life insurance programs and may
participate in our defined contribution 401(k) savings plan on the same terms
as other employees.

CHIEF EXECUTIVE OFFICER COMPENSATION

   During our 1999 fiscal year, our Chief Executive Officer, Richard E.
DeWoskin, received $255,022 in base salary pursuant to his employment
agreement. The terms of Mr. DeWoskin's employment agreement were determined
based principally on compensation levels applicable to the chief executive
officers of similar or competitive companies and secondarily on Mr. DeWoskin's
prior contributions to Northfield and his high level of experience and
involvement with the development and clinical testing of our blood substitute
product.


                                       12
<PAGE>   13


   During our 1999 fiscal year, Mr. DeWoskin was also granted options to
purchase 40,000 shares of common stock pursuant to our 1996 stock option plan.
The terms of the stock options granted to Mr. DeWoskin were determined based on
his contributions to the recent advances in the development and clinical
testing of our blood substitute product.

                                           Members of the Compensation Committee

                                           Richard E. DeWoskin, Chairman
                                           Bruce S. Chelberg
                                           Jack Olshansky


                                       13
<PAGE>   14


                            STOCK PERFORMANCE GRAPH

   The following graph compares the cumulative total return on our common stock
from May 31, 1994 through May 31, 1999 with the CRSP Total Return Index for the
Nasdaq Stock Market (U.S. Companies) and the Nasdaq Pharmaceutical Index. The
total stockholder return assumes that $100 was invested in our common stock and
each of the two indexes on May 31, 1994 and also assumes the reinvestment of any
dividends. The return on our common stock is calculated using the closing price
for the common stock on May 28, 1999, as quoted on The Nasdaq Stock Market,
Inc. Past financial performance may not be a reliable indicator of future
performance, and investors should not use historical trends to anticipate
results or trends in future periods.

                                  [LINE GRAPH]

<TABLE>
<CAPTION>
                                   NORTHFIELD     NASDAQ STOCK        NASDAQ
 MEASUREMENT PERIOD               LABORATORIES     MARKET (US     PHARMACEUTICAL
(FISCAL YEAR COVERED)                INC.          COMPANIES)       STOCK INDEX
<S>                               <C>             <C>             <C>
    May 31, 1994                     100.0           100.0             100.0

    May 31, 1995                     193.0           119.0             109.8

    May 31, 1996                     236.8           172.9             202.2

    May 30, 1997                     138.6           194.8             184.3

    May 29, 1998                     214.9           247.1             191.6

    May 28, 1999                     169.3           347.2             253.1
</TABLE>

                                   ----------

   The Report of the Compensation Committee on Executive Compensation and the
Stock Performance Graph are not deemed to be soliciting material or to be filed
with the Securities and Exchange Commission under the Securities Act of 1933,
as amended, or Securities Exchange Act of 1934, as amended, or incorporated by
reference in any document so filed.


                                       14
<PAGE>   15


                        SECURITY OWNERSHIP OF PRINCIPAL
                          STOCKHOLDERS AND MANAGEMENT

   The following table sets forth information known to us with respect to the
beneficial ownership of our common stock as of May 31, 1999, for (i) each
person who is known by us to be the beneficial owner of more than five percent
of the outstanding common stock, (ii) each of our directors, (iii) each of our
executive officers named under "Management -- Executive Compensation -- Summary
Compensation Table" and (iv) all directors and executive officers as a group.
Except as otherwise indicated, the address of each person named in the
following table is c/o Northfield Laboratories Inc., 1560 Sherman Avenue, Suite
1000, Evanston, Illinois 60201-4800.

<TABLE>
<CAPTION>
                                                                                       PERCENTAGE
                                                                          NUMBER      BENEFICIALLY
               NAME OF STOCKHOLDER                                       OF SHARES      OWNED(1)
- --------------------------------------------------------------------     ---------    ------------
<S>                                                                      <C>          <C>
Richard E. DeWoskin..................................................    702,715(2)       4.9%
Steven A. Gould, M.D.................................................    633,200(3)       4.4%
Jack J. Kogut........................................................    118,560(4)         *
John D. Grove........................................................     50,750(5)         *
John A. Dybas, Jr....................................................     36,500(6)         *
Marc D. Doubleday....................................................     25,000(7)         *
Robert L. McGinnis...................................................      3,750(8)         *
Gerald S. Moss, M.D..................................................    589,150          4.1%

  c/o UIC College of Medicine
  1853 West Polk Avenue
  Chicago, Illinois 60612
Bruce S. Chelberg....................................................  1,502,345(9)      10.6%

  c/o Whitman Corporation
  III Crossroad of Commerce
  3501 Algonquin Road
  Rolling Meadows, Illinois 60008
Jack Olshansky.......................................................     23,017(10)        *

  c/o Montgomery Medical Ventures, L.P.
  3645 Grand Avenue, Suite #302
  Oakland, California 94610
Whitman Corporation..................................................  1,502,345         10.6%

  III Crossroads of Commerce
  3501 Algonquin Road
  Rolling Meadows, Illinois 60008
David A. Savner......................................................     12,000(11)        *

  c/o General Dynamics Corporation
  3190 Fairview Park Drive
  Falls Church, Virginia 22042
All directors and executive officers as a group (eleven persons).....  3,696,987         25.4%
</TABLE>

- ----------

  *  Less than one percent

 (1)  Beneficial ownership is determined in accordance with the rules of the
      Securities and Exchange Commission and generally includes voting or
      investment power with respect to securities. Shares of common stock
      subject to stock options and warrants currently exercisable or
      exercisable within 60 days are deemed outstanding for computing the
      percentage ownership of the person holding the options and the percentage
      ownership of any group of which the holder is a member, but are not
      deemed outstanding for computing the percentage ownership of any other
      person. Except as indicated by footnote, and subject to community
      property laws where applicable, the persons named in the table have sole
      voting and investment power with respect to all shares of common stock
      shown as beneficially owned by them.


                                       15
<PAGE>   16

 (2)  Includes 60,000 shares of common stock which Mr. DeWoskin is entitled to
      acquire pursuant to stock options currently exercisable or exercisable
      within 60 days. Does not include 66,000 shares acquirable pursuant to
      stock options not currently exercisable or exercisable within 60 days.

 (3)  Includes 98,750 shares of common stock which Dr. Gould is entitled to
      acquire pursuant to stock options currently exercisable or exercisable
      within 60 days. Also includes an aggregate of 6,000 shares owned by
      Suzanne Gould and Jeffrey Gould, the children of Dr. Gould, as to which
      Dr. Gould disclaims beneficial ownership. Also includes 484,630 shares
      held in a personal trust and 43,820 shares held in a family trust. Does
      not include 41,250 shares acquirable pursuant to stock options not
      currently exercisable or exercisable within 60 days.

 (4)  Includes 53,750 shares of common stock which Mr. Kogut is entitled to
      acquire pursuant to stock options currently exercisable or exercisable
      within 60 days. Also includes 64,805 shares held in a personal trust.
      Does not include 45,250 shares acquirable pursuant to stock options not
      currently exercisable or exercisable within 60 days.

 (5)  Includes 47,250 shares of common stock which Mr. Grove is entitled to
      acquire pursuant to stock options currently exercisable or exercisable
      within 60 days. Does not include 13,750 shares acquirable pursuant to
      stock options not currently exercisable or exercisable within 60 days.

 (6)  Includes 23,500 shares of common stock which Mr. Dybas is entitled to
      acquire pursuant to stock options currently exercisable or exercisable
      within 60 days. Does not include 17,500 shares acquirable pursuant to
      stock options not currently exercisable or exercisable within 60 days.

 (7)  Includes 23,500 shares of common stock which Mr. Doubleday is entitled
      to acquire pursuant to stock options currently exercisable or exercisable
      within 60 days. Does not include 17,500 shares acquirable pursuant to
      stock options not currently exercisable or exercisable within 60 days.

 (8)  Includes 3,750 shares of common stock which Mr. McGinnis is entitled to
      acquire pursuant to stock options currently exercisable or exercisable
      within 60 days. Does not include 21,250 shares acquirable pursuant to
      stock options not currently exercisable or exercisable within 60 days.

 (9)  Includes shares of common stock held by Whitman Corporation. Mr.
      Chelberg is the Chairman and Chief Executive Officer of Whitman
      Corporation. Under the rules and regulations of the Securities and
      Exchange Commission, Mr. Chelberg may be deemed a beneficial owner of the
      stock held by Whitman Corporation. Mr. Chelberg disclaims beneficial
      ownership of the stock held by Whitman Corporation.

 (10) Includes 15,000 shares of common stock which Mr. Olshansky is entitled
      to acquire pursuant to stock options currently exercisable or exercisable
      within 60 days.

 (11) Includes 10,000 shares of common stock which Mr. Savner is entitled to
      acquire pursuant to stock options currently exercisable or exercisable
      within 60 days. Does not include 5,000 shares acquirable pursuant to
      stock options not currently exercisable or exercisable within 60 days.


                                       16
<PAGE>   17


             ITEM 2. APPROVAL OF SELECTION OF INDEPENDENT AUDITORS

   The Board of Directors has selected KPMG LLP as Northfield's independent
auditors for the fiscal year ending May 31, 2000, and has further directed that
the selection of independent auditors be submitted for approval by the
stockholders at the annual meeting.

   Representatives of KPMG LLP will be present at the annual meeting, will have
the opportunity to make a statement if they desire to do so and will be
available to respond to appropriate questions.


     ITEM 3. APPROVAL OF AMENDMENT TO RESTATED CERTIFICATE OF INCORPORATION


SUMMARY OF THE AMENDMENT

   The Board of Directors has determined that our Restated Certificate of
Incorporation should be amended to increase the number of authorized shares of
our common stock from 20,000,000 to 30,000,000. Specifically, Section 4 of our
Restated Certificate of Incorporation will be amended and restated as set forth
in Annex A, which is located at the end of this document. The other terms and
provisions of our Restated Certificate of Incorporation will remain unchanged.

   As of the record date for the annual meeting, 14,239,875 shares of our
common stock were outstanding, 1,328,000 shares were reserved for issuance
under our stock option plans, leaving only 4,432,125 shares available for
issuance for other purposes. If this proposed amendment is approved, 10,000,000
additional shares of our common stock will be available for future issuance or
sale without further stockholder approval. However, stockholder approval of
particular transactions may at the time be required by law or by the rules or
policies of any exchange or market upon which shares of our common stock may be
traded or quoted. Our common stock is presently quoted on The Nasdaq Stock
Market, Inc. under the symbol "NFLD".

PURPOSE AND EFFECT OF THE AMENDMENT

         Upon approval of this proposed amendment by our stockholders,
10,000,000 additional shares of our common stock would be authorized but
unissued and unreserved. The Board of Directors believes that it is in the best
interest of Northfield to have additional shares of our common stock available
for various general corporate purposes, financing transactions, including stock
splits, stock dividends, benefit plans or acquisitions. The Board of Directors
believes that the additional authorized common stock would give us greater
flexibility by allowing us to issue shares of our common stock without the
expense and delay of a stockholders meeting to authorize additional shares if
and when the need arises.

         We currently have no plans for the issuance of additional shares of
common stock. We have determined, however, that securing stockholder approval of
10,000,000 additional authorized shares of our common stock would be appropriate
in order to provide us with the flexibility to consider possible actions that
might require the future issuance of additional shares of our common stock.

         If the Board of Directors deems it to be in the best interest of
Northfield and our stockholders to issue additional shares of common stock in
the future, the Board of Directors generally will not seek further
authorization by vote of our stockholders, unless such authorization is
otherwise required by law or regulations.

         The issuance of the additional shares of our common stock may have a
dilutive effect on our earnings per share and, for stockholders that do not
purchase additional shares to maintain their pro rata interest in Northfield,
on their percentage of voting power. In addition, the issuance of additional
shares of our common stock authorized by this proposed amendment could have an
anti-takeover effect. For example, the issuance of the additional shares of our
common stock could discourage a potential acquiror by increasing the number of
shares of our common stock necessary to gain control of Northfield, permitting
us, through the public or private issuance of shares of our common stock, to
dilute the stock ownership of the potential acquiror, or permitting us to
privately place shares of our common stock with purchasers who would side with
our Board of Directors in opposing a takeover bid.


                                       17
<PAGE>   18


         This proposed amendment is not being recommended in response to any
specific effort of which our management is aware to accumulate shares or obtain
control of Northfield or for a specific purpose other than general corporate
purposes.

EFFECTIVE DATE

         If this proposed amendment is approved by our stockholders, then the
amendment to our Restated Certificate of Incorporation will become effective
upon the filing of a Certificate of Amendment with the Secretary of State of
Delaware, which will occur as soon as practicable following the approval of
this proposed amendment by our stockholders. Our stockholders have no
dissenters' rights with respect to this proposed amendment and will have no
preemptive rights in connection with the issuance of any new shares of our
common stock.


EXPENSES OF SOLICITATION

     We will bear all expenses of this solicitation, including the cost of
preparing and mailing this document. In addition to solicitation by use of the
mails, proxies may be solicited by our directors, officers and employees in
person or by telephone, telegram or other means of communication. Our
directors, officers and employees will not be additionally compensated, but may
be reimbursed for their reasonable out-of-pocket expenses in connection with
this solicitation. Arrangements will be made for forwarding proxy solicitation
materials to beneficial owners of shares held of record by custodians, nominees
and fiduciaries and we will reimburse these custodians, nominees and
fiduciaries for their reasonable expenses incurred in connection with this
solicitation.

PROCEDURE FOR SUBMITTING STOCKHOLDER PROPOSALS

     Stockholders may present proper proposals for inclusion in Northfield's
proxy statement and for consideration at the next annual meeting of our
stockholders by submitting their proposals to us in a timely manner. In order
to be included for our next annual meeting, stockholder proposals must be
received by us no later than July 8, 2000, and must otherwise comply with the
requirements of the applicable rules of the Securities and Exchange Commission.
In addition, our Restated Bylaws establish an advance notice procedure with
regard to certain matters, including stockholder proposals not included in our
proxy statement, to be brought before any annual meeting of stockholders. In
general, notice must be received by our corporate secretary not less than 60
days nor more than 90 days prior to the date of the annual meeting, except if
less than 70 days' notice or prior public disclosure of the date of the meeting
is given or made to our stockholders, in which event notice by the stockholders
to be timely must be received no later than the close of business on the tenth
day following the date on which notice of the date of the annual meeting was
mailed or public disclosure was made. It is currently expected that the 2000
annual meeting of shareholders will be held on or about October 6, 2000.
Therefore, the deadline for timely submission of a shareholder proposal for
consideration at the 2000 annual meeting is currently expected to be August 7,
2000.

     All notice of proposals by stockholders, whether or not to be included in
our proxy materials, should be sent to Northfield Laboratories Inc., 1560
Sherman Avenue, Suite 1000, Evanston, Illinois 60201-4800, Attention:
Secretary.

GENERAL

     The Board of Directors does not know of any other matters to be presented
at the annual meeting. If any additional matters are properly presented, the
persons named in the proxy will have discretion to vote in accordance with
their own judgment on these matters.


                                       18
<PAGE>   19


                                    ANNEX A

                                SECTION 4 OF THE
                     RESTATED CERTIFICATE OF INCORPORATION
                        OF NORTHFIELD LABORATORIES INC.

                           AS PROPOSED TO BE AMENDED

                  "4.      Authorized Capital Stock. The total number of shares
         of stock which the Corporation shall have authority to issue is
         35,000,000 shares, consisting of 30,000,000 shares of Common Stock,
         par value $.01 per share (the "Common Stock"), and 5,000,000 shares of
         Preferred Stock, par value $.01 per share (the "Preferred Stock").

                  The Preferred Stock may be issued from time to time in one or
         more series. The Board of Directors of the Corporation (the "Board of
         Directors") is expressly authorized to provide for the issuance of the
         Preferred Stock in one or more series, and to fix the number of shares
         and to determine or alter for each such series, such voting powers,
         full or limited, or no voting powers, and such designations,
         preferences, and relative, participating, optional or other rights,
         and such qualifications, limitations or restrictions thereof, as shall
         be stated and expressed in the resolution or resolutions adopted by
         the Board of Directors providing for the issuance of such shares and
         as may be permitted by the General Corporation Law of the State of
         Delaware. The Board of Directors is also expressly authorized to
         increase or decrease (but not below the number of shares of such
         series outstanding) the number of shares of any series subsequent to
         the issuance of shares of such series. In case the number of shares of
         any such series shall so decrease, the shares constituting such
         decrease shall resume the status that they had prior to the adoption
         of the resolution originally fixing the number of shares of such
         series."


                                       19
<PAGE>   20
                                                                PRELIMINARY COPY

PROXY                     NORTHFIELD LABORATORIES INC.               PROXY

ANNUAL MEETING OF STOCKHOLDERS-OCTOBER 28, 1999

          THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS.

   The undersigned stockholder of Northfield Laboratories Inc. hereby appoints
Jack J. Kogut and Carmen Wilcox, and each of them, attorneys and proxies, with
full power of substitution, to vote at the Annual Meeting of the stockholders
of Northfield Laboratories Inc. to be held on Thursday, October 28, 1999, at
2:00 P.M., local time, at 1560 Sherman Avenue, Evanston, Illinois 60201-4800,
and at any adjournment or postponement thereof, in the name of the undersigned
and with the same force and effect as if the undersigned were present and
voting such shares, on the following matters and in the following manner.

   The shares represented by this proxy will be voted in accordance with the
specifications made hereon. If no specification is made, the shares represented
by this proxy will be voted by each of the above persons for each of the
proposals to be presented at the Annual Meeting and for such other matters as
may properly come before the Annual Meeting as the above persons may deem
advisable.

   PLEASE MARK, SIGN, DATE AND MAIL THIS PROXY CARD PROMPTLY USING THE ENCLOSED
ENVELOPE.

                 (Continued and to be signed on reverse side.)

   NORTHFIELD LABORATORIES INC. PLEASE MARK VOTE IN OVAL IN THE FOLLOWING
MANNER USING DARK INK ONLY.

The Board of Directors recommends a vote "FOR" each of the listed proposals.

<TABLE>
<S>                                                                <C>   <C>          <C>
                                                                   FOR   WITHHOLD
                                                                   ALL   ALL          FOR ALL (Except Nominee(s) written below)

    1.  ELECTION OF DIRECTORS --

        Nominees: Richard E. DeWoskin, Steven A. Gould, M.D.,      [ ]   [ ]          [ ]
        Gerald S. Moss, M.D., Bruce S. Chelberg, Jack Olshansky                                ---------------------------------
        and David A. Savner

                                                                   FOR   AGAINST      ABSTAIN

    2.  To approve the appointment of KPMG LLP                     [ ]   [ ]          [ ]
        as independent auditors of the Company to serve for the
        Company's 2000 fiscal year.

                                                                   FOR   AGAINST      ABSTAIN

    3.  To approve the proposal to amend the Company's             [ ]   [ ]          [ ]
        Restated Certificate of Incorporation to increase the
        number of authorized shares of the Company's Common Stock,
        par value $.01 per share, from 20,000,000 to 30,000,000.

    4.  In their discretion, to act on any other matters which may
        Properly come before the Annual Meeting and any
        adjournment or postponement thereof.
</TABLE>

                                       20
<PAGE>   21

  Dated:                   , 1999
        ------------------

                   Signature(s)

                                     Sign exactly as your name(s) appear hereon.
                                     When signing as attorney, administrator,
                                     trustee, guardian or other representative
                                     capacity, please so indicate.

                            * FOLD AND DETACH HERE *

                            YOUR VOTE IS IMPORTANT!

          PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY
                      USING THE ENCLOSED PREPAID ENVELOPE.


                                       21


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