TARGETED GENETICS CORP /WA/
10-Q, 1997-08-08
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                    FORM 10-Q

          (Mark One)

          [ x ] Quarterly report pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                  For the quarterly period ended June 30, 1997
                                       or
          [   ] Transition report pursuant to Section 13 or 15(d) of the the
                         Securities Exchange Act of 1934

             For the transition period from _________ to __________


                         Commission File Number: 0-23930
                          ----------------------------


                          TARGETED GENETICS CORPORATION
- --------------------------------------------------------------------------------
             (Exact name of registrant as specified in its charter)

              Washington                                91-1549568
- ------------------------------------      --------------------------------------
    (State or other jurisdiction of        (I.R.S. Employer Identification No.)
    incorporation or organization)

  1100 Olive Way, Suite 100, Seattle, Washington 98101            98101
- --------------------------------------------------------------------------------
     (Address of principal executive offices)                   (Zip Code)

                                 (206) 623-7612
- --------------------------------------------------------------------------------
              (Registrant's telephone number, including area code)


        Indicate by check mark whether the registrant: (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.

       Yes      [ x ]         No    [    ]


        Indicate the number of shares outstanding of each of the issuer's
classes of common stock, as of the latest practicable date.

   Common Stock, $.01 par value                       20,206,874
- --------------------------------------------------------------------------------
             (Class)                      (Outstanding at August 1, 1997)


<PAGE>   2

                          TARGETED GENETICS CORPORATION

                          Quarterly Report on Form 10-Q
                       For the quarter ended June 30, 1997

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                        Page No.
                                                                        --------
<S>      <C>                                                               <C>  
PART I      FINANCIAL INFORMATION

Item 1.     Financial Statements

         a) Condensed Balance Sheets - June 30, 1997 and
                  December 31, 1996                                         3

         b) Condensed Statements of Operations - for the three and
                  six months ended June 30, 1997 and 1996                   4

         c) Condensed Statements of Cash Flows - for the three and
                  six months ended June 30, 1997 and 1996                   5

         d) Notes to Condensed Financial Statements                         6

Item 2.     Management's Discussion and Analysis of Financial Condition
                  and Results of Operations                                 6

Item 3.     Quantitative and Qualitative Disclosure About Market Risk       *


PART II     OTHER INFORMATION

Item 1.     Legal Proceedings                                               *

Item 2.     Changes in Securities                                           *

Item 3.     Defaults Upon Senior Securities                                 *

Item 4.     Submission of Matters to a Vote of Security Holders             9

Item 5.     Other Information                                               *

Item 6.     Exhibits and Reports on Form 8-K                                10


SIGNATURES                                                                  11
</TABLE>


    * No information is provided due to inapplicability of the item.





                                        2
<PAGE>   3
PART I    FINANCIAL INFORMATION

ITEM 1.  FINANCIAL STATEMENTS

                          TARGETED GENETICS CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                            CONDENSED BALANCE SHEETS


<TABLE>
<CAPTION>
                                                             June 30,         December 31,
                                                               1997               1996
                                                           ------------       ------------
ASSETS                                                      (Unaudited)

<S>                                                        <C>                <C>         
Current assets:
     Cash and cash equivalents                             $    165,953       $  3,532,568
     Securities available for sale                           11,695,920         15,518,502
     Prepaid expenses and other                                 350,634            468,671
                                                           ------------       ------------
          Total current assets                               12,212,507         19,519,741

Property, plant and equipment, net                            4,488,949          4,991,017

Other assets                                                    567,738            628,294
                                                           ------------       ------------

                                                           $ 17,269,194       $ 25,139,052
                                                           ============       ============

LIABILITIES AND SHAREHOLDERS' EQUITY

Current liabilities:
     Accounts payable                                      $  1,347,518       $  1,887,880
     Accrued payroll and other liabilities                      283,022            364,964
     Current portion of long-term obligations                 1,134,538          1,250,263
                                                           ------------       ------------
          Total current liabilities                           2,765,078          3,503,107

Long-term obligations                                         1,977,015          2,128,157

Shareholders' equity:
     Preferred stock                                               --                 --
     Common stock (20,206,874 and 20,136,468 shares
       outstanding at  June 30, 1997 and December 31,
       1996, respectively)                                   73,398,369         73,115,362
     Deficit accumulated during development stage           (60,871,268)       (53,607,574)
                                                           ------------       ------------
          Total shareholders' equity                         12,527,101         19,507,788
                                                           ------------       ------------

                                                           $ 17,269,194       $ 25,139,052
                                                           ============       ============
</TABLE>

                             See accompanying notes.

                                        3

<PAGE>   4
ITEM 1.  FINANCIAL STATEMENTS (CONTINUED)

                          TARGETED GENETICS CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                       CONDENSED STATEMENTS OF OPERATIONS
                                   (Unaudited)


<TABLE>
<CAPTION>
                                       Three months ended              Six months ended           March 9, 1989
                                            June 30,                        June 30,           (date of inception)    
                                  ----------------------------    ----------------------------       through
                                      1997            1996            1997            1996        June 30, 1997
                                  ------------    ------------    ------------    ------------    ------------  
<S>                               <C>             <C>             <C>             <C>             <C>         
Revenues:
     Collaborative agreements     $      3,048    $     75,000    $     80,430    $     75,000    $  1,358,395
     Investment income                 180,478         155,277         410,814         338,813       3,411,816
     Other                              98,254            --           196,509            --           423,627
                                  ------------    ------------    ------------    ------------    ------------
           Total revenues              281,780         230,277         687,753         413,813       5,193,838
                                  ------------    ------------    ------------    ------------    ------------

Expenses:
     Research and development        3,316,897       2,431,607       6,368,435       4,797,639      40,642,139
     In-process research
        and development                   --        13,517,911            --        13,517,911      13,517,911
     General and administrative        644,762         554,111       1,387,332       1,170,973      10,836,368
     Interest                           94,627         103,125         181,520         195,506       1,073,915
                                  ------------    ------------    ------------    ------------    ------------
           Total expenses            4,056,286      16,606,754       7,937,287      19,682,029      66,070,333
                                  ------------    ------------    ------------    ------------    ------------

Net loss                          $ (3,774,506)   $(16,376,477)   $ (7,249,534)   $(19,268,216)   $(60,876,495)
                                  ============    ============    ============    ============    ============

Net loss per share                $      (0.19)          (1.26)   $      (0.36)   $      (1.52) 
                                  ============    ============    ============    ============

Shares used in computation of
    net loss per share              20,205,624      13,031,247      20,183,954      12,690,294
                                  ============    ============    ============    ============
</TABLE>






                             See accompanying notes.

                                        4
<PAGE>   5
ITEM 1.  FINANCIAL STATEMENTS (CONTINUED)

                          TARGETED GENETICS CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                       CONDENSED STATEMENTS OF CASH FLOWS
                                   (Unaudited)



<TABLE>
<CAPTION>
                                                                Six months ended          March 9, 1989
                                                                    June 30,           (date of inception)
                                                          ----------------------------       through
                                                              1997            1996        June 30, 1997
                                                          ------------    ------------    ------------

<S>                                                       <C>             <C>             <C>          
Net cash used in operating activities                     $ (6,614,077)   $ (5,558,934)   $(40,953,258)

Investing activities:
Purchases of property, plant and equipment                    (528,271)       (991,593)     (9,241,462)
Purchases of securities available for sale                        --       (12,504,553)    (78,664,645)
Sales of securities available for sale                       3,759,715       7,720,112      67,080,742
Net cash acquired in RGene acquisition                            --         2,977,185       1,594,386
Increase in other assets                                          --              --          (719,179)
                                                          ------------    ------------    ------------

    Net cash provided by (used in) investing activities      3,231,444      (2,798,849)    (19,950,158)

Financing activities:
Advances from Immunex                                             --              --         2,807,316
Net proceeds from sale of capital stock                        283,007      13,245,848      55,658,007
Proceeds from equipment financing                              326,287         646,996       5,270,169
Payments under capital leases and installment loans           (593,276)       (451,344)     (2,666,123)
                                                          ------------    ------------    ------------

    Net cash provided by financing activities                   16,018      13,441,500      61,069,369
                                                          ------------    ------------    ------------

Net increase (decrease) in cash and cash equivalents        (3,366,615)      5,083,717         165,953

Cash and cash equivalents, beginning of period               3,532,568       2,154,814            --
                                                          ------------    ------------    ------------

Cash and cash equivalents, end of period                  $    165,953    $  7,238,531    $    165,953
                                                          ============    ============    ============
</TABLE>



                             See accompanying notes.

                                        5
<PAGE>   6
ITEM 1.  FINANCIAL STATEMENTS (CONTINUED)

                          TARGETED GENETICS CORPORATION
                          (A DEVELOPMENT STAGE COMPANY)
                     NOTES TO CONDENSED FINANCIAL STATEMENTS
                                   (Unaudited)

Note 1.  Basis of Presentation
      The condensed financial statements included herein have been prepared by
Targeted Genetics Corporation (the "Company"), without audit, according to the
rules and regulations of the Securities and Exchange Commission. Certain
information and footnote disclosures normally included in financial statements
prepared in accordance with generally accepted accounting principles have been
omitted pursuant to such rules and regulations. The financial statements
reflect, in the opinion of management, all adjustments (which consist solely of
normal recurring adjustments) necessary to present fairly the financial position
and results of operations as of and for the periods indicated.

      The results of operations for the three and six months ended June 30, 1997
are not necessarily indicative of the results to be expected for the full year.

Note 2.  Loss Per Share
      In February 1997, the Financial Accounting Standards Board issued
Statement No. 128, Earnings per Share ("Statement 128"), which is required to be
adopted on December 31, 1997. At that time, the Company will be required to
change the method currently used to compute earnings per share and to restate
all prior periods presented. The impact of Statement 128 on the calculation of
net loss per share for all current and prior periods is not expected to be
material.

ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS

Risks and Uncertainties
      This discussion contains forward-looking statements that are subject to
certain risks and uncertainties that could cause actual results to differ
materially from those projected. The Company's future cash requirements and
expense levels will depend on many factors, including continued scientific
progress in its research and development programs; the results of research and
development, preclinical studies and clinical trials; acquisition of products or
technology, if any; relationships with corporate collaborators; competing
technological and market developments; the time and costs involved in filing,
prosecuting and enforcing patent claims; the time and costs of manufacturing
scale-up and commercialization activities; and other factors. Reference is made
to the Company's Annual Report on Form 10-K for more detailed description of
such factors. Readers are cautioned not to place undue reliance on these
forward-looking statements, which speak only as of the date of this report. The
Company undertakes no obligation to publicly release the results of any
revisions to these forward-looking statements that may be made to reflect events
or circumstances after the date of this report or to reflect the occurrence of
unanticipated events.


                                        6
<PAGE>   7
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS (CONTINUED)

Financial Condition
      The Company had cash, cash equivalents and securities available for sale
totaling $11.9 million as of June 30, 1997, compared to $19.0 million at
December 31, 1996. The change was primarily attributable to the use of $6.6
million to fund operations and $528,000 to purchase property, plant and
equipment during the first six months of 1997, offset by the receipt of $277,000
for the exercise of warrants by existing shareholders.

      The Company is a development stage company conducting gene and cell
therapy research and development. Income earned from investments and, to a
lesser degree, revenues under collaborative agreements have been its only
sources of revenue, covering less than ten percent of expenses. Gene and cell
therapy products are subject to the risks of failure inherent in the development
of products based on innovative technologies. Although the Company's technology
appears promising, it is unknown whether any commercially viable products will
result from the research and development. It is not anticipated that the Company
will have any product-related revenues for a number of years. Accordingly, the
Company expects to incur substantial additional losses over the next several
years and to use its capital resources to fund preclinical and clinical research
programs, development of manufacturing capabilities and the preparation for
commercialization of its products under development.

      The Company currently estimates that, at its planned rate of spending, its
existing cash, cash equivalents and securities available for sale will be
sufficient to meet its operating and capital requirements until at least early
1998. Such estimates include the impact of future milestone payments potentially
receivable under existing collaborative agreements. There can be no assurance
that such milestone payments will be received or that the underlying assumed
levels of revenue and expense will prove to be accurate. In any event,
substantial additional funds will be needed to continue the development and
commercialization of the Company's products. Accordingly, the Company is seeking
to establish additional collaborative agreements with corporate partners that
would provide research and development funding and equity investment. The
Company also may seek to raise additional equity capital whenever conditions in
the financial markets allow it to do so. There can be no assurance, however,
that adequate funds will be available when needed or will be available on terms
favorable to the Company, if at all.

Results of Operations
      Over the past several years, the Company's net loss has grown, consistent
with the growth in the Company's scope and size of operations. In the near term,
the Company does not expect additional growth in employee headcount or
facilities; however, the Company estimates that operating expenses will continue
to increase moderately as a result of continuing with its current operating
plan, which includes growth in the level of clinical trial activity. At least
until such time as the Company enters into an arrangement providing research and
development funding, the net loss will continue to increase as well.



                                       7
<PAGE>   8
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
OF OPERATIONS (CONTINUED)

Results of Operations (continued)
      Revenue under collaborative agreements for the three and six months ended
June 30, 1997 primarily consists of amounts earned from Laboratoires Fournier
S.C.A. related to tgDCC-E1A process development activities.

      Investment income for the three and six months ended June 30, 1997
increased to $181,000 and $411,000 compared to $155,000 and $339,000, during the
three and six months ended June 30, 1996, respectively. The increase was largely
attributable to higher average cash balances for investment in 1997 compared to
the same periods in 1996.

      Other revenue for the three and six months ended June 30, 1997 represents
proceeds from Small Business Innovation Research grants awarded by the National
Institutes of Health.

      Research and development expenses were $3,317,000 and $6,368,000 for the
three and six months ended June 30, 1997, respectively, and $2,432,000 and
$4,798,000 for the three and six months ended June 30, 1996, respectively.
Expenses that resulted directly from the acquisition of RGene Therapeutics Inc.
("RGene"), specifically costs related to the continuation of the acquired
research, development and clinical programs, were largely responsible for the
increases in both the three- and six-month period. To a lesser extent, continued
progression of the Company's clinical trial programs and increased activity
related to intellectual property also contributed to the increases.

      In-process research and development expense resulted from the acquisition
of RGene in the second quarter of 1996. The RGene purchase price exceeded the
fair value of tangible assets acquired and the excess was allocated to RGene's
existing in-process technology and written off in the second quarter to
in-process research and development.

      General and administrative expenses for the three- and six-month periods
experienced moderate increases primarily attributable to an increased level of
corporate development activities focused on the completion of additional
corporate collaborations.



                                       8
<PAGE>   9
PART II     OTHER INFORMATION

ITEM 4.  SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
      An annual meeting of the Company's shareholders ("Shareholders") was held
on May 7, 1997 (the "Annual Meeting"). Of the 20,205,434 shares outstanding as
of the record date, March 7, 1997, 16,610,986 shares, or 82.21% of the total
shares eligible to vote at the Annual Meeting, were represented in person or by
proxy.

      Two matters were submitted to a vote of the Shareholders at the Annual
Meeting. First, an amendment to the 1994 Stock Option Plan for Nonemployee
Directors providing for an increase in the number of shares available for grant
from 120,000 to 300,000 was approved by 99.6% of the votes represented at the
meeting. Second, H. Stewart Parker, Mark Richmond, Martin P. Sutter and Jack L.
Bowman were elected as Directors of the Company, each receiving greater than 99%
of the votes cast at the meeting.

      No other matters were submitted to a vote of the Shareholders.



                                       9
<PAGE>   10
PART II     OTHER INFORMATION

ITEM 6.  EXHIBITS AND REPORTS ON FORM 8-K

(a)   The following exhibits are filed as part of this report.

    Exhibit No.                   Description
    -----------                   -----------

        4.1     Warrant to purchase 25,000 shares of the Common Stock of
                Targeted Genetics Corporation, issued to Francis Chisari on May
                15, 1997.

        27.1    Financial Data Schedule



                                       10
<PAGE>   11
                                   SIGNATURES

        Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.



                                        TARGETED GENETICS CORPORATION
                               -------------------------------------------------
                                                  (Registrant)



Date     August 7, 1997           /s/  H. STEWART PARKER
     -----------------------   -------------------------------------------------
                                  H. Stewart Parker, Chief Executive Officer
                                  (Principal Executive Officer)



Date     August 7, 1997           /s/  JAMES A. JOHNSON
     -----------------------   -------------------------------------------------
                                  James A. Johnson, Vice President, Finance
                                  (Principal Financial and Accounting Officer)


                                       11
<PAGE>   12

                                 EXHIBIT INDEX


    Exhibit No.                   Description
    -----------                   -----------

        4.1     Warrant to purchase 25,000 shares of the Common Stock of
                Targeted Genetics Corporation, issued to Francis Chisari on May
                15, 1997.

        27.1    Financial Data Schedule



<PAGE>   1

                                                                     Exhibit 4.1

THIS WARRANT AND THE SECURITIES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE
LAWS, AND NO INTEREST THEREIN MAY BE SOLD, DISTRIBUTED, ASSIGNED, OFFERED,
PLEDGED OR OTHERWISE TRANSFERRED UNLESS THERE IS AN EFFECTIVE REGISTRATION
STATEMENT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES LAWS COVERING ANY SUCH
TRANSACTION OR SUCH TRANSACTION IS EXEMPT FROM THE REGISTRATION REQUIREMENTS OF
SUCH ACT AND LAWS.


                          TARGETED GENETICS CORPORATION

                              COMMON STOCK WARRANT

This certifies that for value received, FRANCIS CHISARI ("Chisari"), or
registered assigns, is entitled, upon the terms and subject to the conditions
hereinafter set forth, at any time on or after the date hereof (subject to the
provisions of Section 1) and at or prior to 11:59 p.m., Pacific time, on May 15,
2004 (the "Expiration Time"), but not thereafter, to acquire from TARGETED
GENETICS CORPORATION, a Washington corporation (the "Company"), in whole or from
time to time in part, up to a maximum of 25,000 fully paid and nonassessable
shares of Common Stock ("Warrant Stock") at a purchase price per share (the
"Exercise Price") of $3.13. Such number of shares, type of security and Exercise
Price are subject to adjustment as provided herein, and all references to
"Warrant Stock" and "Exercise Price" herein shall be deemed to include any such
adjustment.

1.    VESTING OF WARRANTS
The rights to purchase Warrant Stock pursuant to this Warrant shall exercisable
according to the following schedule: 
(a) 20% immediately; and 
(b) an additional 20% on each anniversary date beginning May 15, 1998.

2.    EXERCISE OF WARRANT
Subject to the vesting requirements set forth in Section 1 hereof and to the
termination provisions of Sections 10 and 12 hereof, the purchase rights
represented by this Warrant are exercisable by the registered holder hereof, in
whole or in part, at any time and from time to time at or prior to the
Expiration Time by the surrender of this Warrant and the Notice of Exercise form
attached hereto duly executed to the office of the Company at 1100 Olive Way,
Suite 100, Seattle, Washington 98101 (or such other office or agency of the
Company as it may designate by notice in writing to the registered holder hereof
at the address of such holder appearing on the books of the Company), and upon
payment of the Exercise Price for the shares thereby purchased (by cash or by
check or bank draft payable to the order of the Company or by cancellation of
indebtedness of the Company to the holder hereof, if any, at the time of
exercise in an amount equal to the purchase price of the shares thereby
purchased); whereupon the holder of this Warrant shall be entitled to receive
from the Company a stock certificate in proper form representing the number of
shares of Warrant Stock so purchased.

3.    SECURITIES ACT COMPLIANCE
As a condition of its delivery of the certificates for the Warrant Stock, the
Company may require the registered holder hereof (or the transferee, if any, of
the Warrant Stock in whose name the shares of Warrant Stock are to be
registered) to deliver to the Company, in writing, representations regarding the
purchaser's sophistication, investment intent, acquisition for his, her or its
own account and such other matters as are reasonable and customary for
purchasers of securities in an unregistered private offering and the Company may
place 


                                       12
<PAGE>   2
conspicuously upon each certificate representing shares of Warrant Stock a
legend substantially in the following form, the terms of which are agreed to by
the registered holder hereof (including any transferee of this Warrant or the
Warrant Stock):

         THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
         UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR APPLICABLE
         STATE LAW, AND NO INTEREST THEREIN MAY BE SOLD, DISTRIBUTED, ASSIGNED,
         OFFERED, PLEDGED OR OTHERWISE TRANSFERRED UNLESS (I) THERE IS AN
         EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT AND APPLICABLE STATE
         SECURITIES LAWS COVERING ANY SUCH TRANSACTION INVOLVING SAID
         SECURITIES, (II) THIS CORPORATION RECEIVES AN OPINION OF LEGAL COUNSEL
         FOR THE HOLDER OF THESE SECURITIES SATISFACTORY TO THIS CORPORATION
         STATING THAT SUCH TRANSACTION IS EXEMPT FROM REGISTRATION, OR (III)
         THIS CORPORATION OTHERWISE SATISFIES ITSELF THAT SUCH TRANSACTION IS
         EXEMPT FROM REGISTRATION.

4.    ISSUANCE OF SHARES; NO FRACTIONAL SHARES OR SCRIP
Certificates for shares purchased hereunder shall be delivered to the holder
hereof within a reasonable time after the date on which this Warrant shall have
been exercised in accordance with the terms hereof. The Company agrees that the
shares so issued shall be, and be deemed to be, issued to such holder as the
record owner of such shares as of the close of business on the date on which
this Warrant shall have been exercised in accordance with the terms hereof. No
fractional shares or scrip representing fractional shares shall be issued upon
the exercise of this Warrant. With respect to any fraction of a share called for
upon the exercise of this Warrant, an amount equal to such fraction multiplied
by the then current price at which each share may be purchased hereunder shall
be paid in cash or check to the holder of this Warrant.

5.    CHARGES, TAXES AND EXPENSES
Issuance of certificates for shares of Warrant Stock upon the exercise of this
Warrant shall be made without charge to the holder hereof for any issue or
transfer tax or other incidental expense in respect of the issuance of such
certificate, all of which taxes and expenses shall be paid by the Company, and
such certificates shall be issued in the name of the holder of this Warrant or
in such name or names as may be directed by the holder of this Warrant;
provided, however, that in the event certificates for shares of Warrant Stock
are to be issued in a name other than the name of the holder of this Warrant,
this Warrant when surrendered for exercise shall be accompanied by the
Assignment Form attached hereto duly executed by the holder hereof.

6.    NO RIGHTS AS SHAREHOLDER
This Warrant does not entitle the holder hereof to any voting rights or other
rights as a shareholder of the Company prior to the exercise hereof.

7.    EXCHANGE AND REGISTRY OF WARRANT
This Warrant is exchangeable, upon the surrender hereof by the registered holder
at the above-mentioned office or agency of the Company, for a new Warrant of
like tenor and dated as of such exchange. The Company shall maintain at the
above-mentioned office or agency a registry showing the name and address of the
registered holder of this Warrant. This Warrant may be surrendered for exchange,
transfer or exercise, in accordance with its terms and subject to compliance
with applicable laws, at such office or agency of the Company, and the Company
shall be entitled to rely in all respects, prior to written notice to the
contrary, upon such registry.

8.    LOSS, THEFT, DESTRUCTION OR MUTILATION OF WARRANT
Upon receipt by the Company of evidence reasonably satisfactory to it of the
loss, theft, destruction or mutilation of this Warrant, and (in the case of
loss, theft or destruction) upon receipt of indemnity or security reasonably
satisfactory to it, and upon reimbursement to the Company of all reasonable
expenses incidental 


                                       13
<PAGE>   3

thereto, and (in the case of mutilation) upon surrender and cancellation of this
Warrant, the Company will make and deliver a new warrant of like tenor and dated
as of such cancellation, in lieu of this Warrant.

9.    SATURDAYS, SUNDAYS AND HOLIDAYS
If the last or appointed day for the taking of any action or the expiration of
any right required or granted herein shall be a Saturday or a Sunday or shall be
a legal holiday, then such action may be taken or such right may be exercised on
the next succeeding day not a legal holiday.

10.   MERGER, SALE OF ASSETS, ETC.
If at any time the Company proposes to merge or consolidate with or into any
other corporation, effect any reorganization, or sell or convey all or
substantially all of its assets to any other entity, in a transaction in which
the shareholders of the Company immediately before the transaction will own
immediately after the transaction less than a majority of the outstanding voting
securities of the entity (or its parent) succeeding to the business of the
Company (each such transaction, a "corporate transaction"), then the Company
shall give the holder of this Warrant 20 days' prior written notice of the
proposed effective date of such corporate transaction. The holder of this
Warrant shall have the right, effective as of the consummation of such corporate
transaction, to exercise this Warrant in whole or in part whether or not the
vesting requirements set forth herein have been satisfied; provided, however,
that this Warrant may not be exercised as to any unvested portion if this
Warrant is assumed by the successor entity (or its parent) in the corporate
transaction or replaced with a substantially equivalent warrant (subject to the
same vesting schedule as is contained in Section 1 hereof) for the purchase of
an amount of securities of the successor entity (or its parent) which the holder
of this Warrant would have received in the corporate transaction had the
unexercised portion of this Warrant (including the unvested portion) been
exercised in full immediately prior thereto. If this Warrant has not been
exercised by or on the effective date of such corporate transaction, it shall
terminate.

11.   RECLASSIFICATION, CONVERSION, ETC.
If the Company at any time shall, by reclassification of securities or
otherwise, change the Warrant Stock into the same or a different number of
securities of any class or classes, this Warrant shall thereafter entitle the
holder to acquire such number and kind of securities as would have been issuable
in respect of the Warrant Stock (or other securities which were subject to the
purchase rights under this Warrant immediately prior to such subdivision,
combination, reclassification or other change) as the result of such change if
this Warrant had been exercised in full for cash immediately prior to such
change. The Exercise Price hereunder shall be adjusted if and to the extent
necessary to reflect such change. If the Warrant Stock or other securities
issuable upon exercise hereof are subdivided or combined into a greater or
smaller number of shares of such security, the number of shares issuable
hereunder shall be proportionately increased or decreased, as the case may be,
and the Exercise Price shall be proportionately reduced or increased, as the
case may be, in both cases according to the ratio which the total number of
shares of such security to be outstanding immediately after such event bears to
the total number of shares of such security outstanding immediately prior to
such event. The Company shall give the holder prompt written notice of any
change in the type of securities issuable hereunder, any adjustment of the
Exercise Price for the securities issuable hereunder, and any increase or
decrease in the number of shares issuable hereunder.

12.   TERMINATION
As consideration for this Warrant, Chisari has entered into that certain
Consulting Agreement with the Company, dated as of May 15, 1997 (the "Consulting
Agreement"). In the event of the breach of any representation or warranty or
covenant of Chisari under the Consulting Agreement, this Warrant shall
immediately terminate and shall be of no further force or effect. Unless
terminated pursuant to this Section 12, or on the effective date of a corporate
transaction as provided in Section 10, this Warrant shall remain in full force
and effect. In particular, this Warrant shall remain in full force and effect if
the Consulting Agreement is terminated, or if the Company abandons the research
program in the Field (as defined in the Consulting 


                                       14
<PAGE>   4

Agreement), for any reason other than the breach of any representation or
warranty or covenant of Chisari contained therein.

13.   REPRESENTATIONS AND WARRANTIES
The Company hereby represents, warrants and covenants to the holder hereof that:

            (a) during the period this Warrant is outstanding, the Company will
reserve from its authorized and unissued Common Stock a sufficient number of
shares to provide for the issuance of Warrant Stock upon the exercise of this
Warrant;

            (b) the issuance of this Warrant shall constitute full authority to
the Company's officers who are charged with the duty of executing stock
certificates to execute and issue, or cause to be issued, the necessary
certificates for the shares of Warrant Stock issuable upon exercise of this
Warrant;

            (c) the Company has all requisite legal and corporate power to
execute and deliver this Warrant, to sell and issue the Warrant Stock hereunder
and perform its obligations under the terms of this Warrant;

            (d) the Warrant Stock, when issued in compliance with the provisions
of this Warrant and the Company's Articles of Incorporation and Bylaws, will be
validly issued, fully paid and nonassessable, and free of any liens or
encumbrances (other than liens or encumbrances created by or imposed upon the
holder of the Warrant Stock), and will be issued in compliance with all
applicable federal and state securities laws.

14.   COOPERATION
The Company will not, by amendment of its Articles of Incorporation or through
any reorganization, recapitalization, transfer of assets, consolidation, merger,
dissolution, issue or sale of securities or any other action, avoid or seek to
avoid the observance or performance of any of the terms to be observed or
performed hereunder by the Company, but will at all times in good faith assist
in the carrying out of all the provisions of this Warrant and in the taking of
all such reasonable action as may be necessary or appropriate in order to
protect the rights of the holder of the Warrant against material impairment.

15.   GOVERNING LAW
This Warrant shall be governed by and construed in accordance with the laws of
the state of Washington. IN WITNESS WHEREOF, the Company has caused this Warrant
to be executed by its duly authorized officer.

Dated:  May 15, 1997
                                    TARGETED GENETICS CORPORATION


                                    By   /s/ H. Stewart Parker
                                    Title   President & CEO

ACCEPTED: 19 May, 1997


/s/ Francis Chisari
- -------------------

Francis Chisari


                                       15
<PAGE>   5

                                NOTICE OF EXERCISE

To:   Targeted Genetics Corporation
(1) The undersigned hereby elects to purchase __________ shares of Common Stock
of Targeted Genetics Corporation pursuant to the terms of the attached Warrant,
and tenders herewith payment of the purchase price in full, together with all
applicable transfer taxes, if any. 
(2) Please issue a certificate or certificates representing said shares of
Common Stock in the name of the undersigned or in such other name as is
specified below:

                        --------------------------------
                                     (Name)



                        --------------------------------
                                    (Address)

(3) The undersigned represents that the aforesaid shares of Common Stock are
being acquired for the account of the undersigned for investment and not with a
view to, or for resale in connection with, the distribution thereof and that the
undersigned has no present intention of distributing or reselling such shares.


- ----------------------------------    -----------------------------------
             (Date)                              (Signature)


                                       16
<PAGE>   6

                                 ASSIGNMENT FORM

         (To assign the foregoing Warrant, execute this form and supply
         required information. Do not use this form to purchase shares.)

FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are
hereby assigned to


________________________________________________________________________________
                                  (Please Print)

whose address is________________________________________________________________
                                  (Please Print)

                              Dated:____________________________________________
                              Holder's Signature:_______________________________
                              Holder's Address:_________________________________
                              __________________________________________________

Guaranteed Signature:___________________________________________________________

NOTE: The signature to this Assignment Form must correspond with the name as it
appears on the face of the Warrant, without alteration or enlargement or any
change whatever, and must be guaranteed by a bank or trust company. Officers of
corporations and those acting in a fiduciary or other representative capacity
should file proper evidence of authority to assign the foregoing Warrant.



                                       17

<TABLE> <S> <C>

<ARTICLE> 5
       
<S>                             <C>
<PERIOD-TYPE>                   6-MOS
<FISCAL-YEAR-END>                          DEC-31-1997
<PERIOD-START>                             JAN-01-1997
<PERIOD-END>                               JUN-30-1997
<CASH>                                         165,953
<SECURITIES>                                11,695,920
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                            12,212,507
<PP&E>                                       9,920,018
<DEPRECIATION>                             (5,431,069)
<TOTAL-ASSETS>                              17,269,194
<CURRENT-LIABILITIES>                        2,765,078
<BONDS>                                              0
                                0
                                          0
<COMMON>                                    73,398,369
<OTHER-SE>                                           0
<TOTAL-LIABILITY-AND-EQUITY>                17,269,194
<SALES>                                              0
<TOTAL-REVENUES>                               687,753
<CGS>                                                0
<TOTAL-COSTS>                                        0
<OTHER-EXPENSES>                             7,755,767
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                             181,520
<INCOME-PRETAX>                                      0
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                        (7,249,534)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                               (7,249,534)
<EPS-PRIMARY>                                    (.36)
<EPS-DILUTED>                                    (.36)
        

</TABLE>


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