ZYMETX INC
4, 1997-11-25
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>   1
                                                  ------------------------------
                                                           OMB APPROVAL
                                                  ------------------------------
                                                        OMB NUMBER 3235-0287
                                                    EXPIRES: SEPTEMBER 30, 1998
                                                     ESTIMATED AVERAGE BURDEN 
                                                  HOURS PER RESPONSE . . . . 0.5
                                                  ------------------------------
- ------
FORM 4             U.S. SECURITIES AND EXCHANGE COMMISSION
- ------                     WASHINGTON, D.C.  20549

                 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

[ ] CHECK THIS BOX IF NO LONGER
    SUBJECT TO SECTION 16.  FORM 4 
    OR FORM 5 OBLIGATIONS MAY 
    CONTINUE.  SEE INSTRUCTION 1(b).

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section
 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f) of
                      the Investment Company Act of 1940

(Print or Type Responses)

<TABLE>
<S>                                        <C>                                            <C>
1.  Name and Address of Reporting Person   2.  Issuer Name and Ticker or Trading Symbol   3.  IRS or Social Security Number of 
                                                                                              Reporting Person (Voluntary)     
    Gibson       Gilbert        Carl Jr                  Zymtex/ZMTX                              ###-##-####
    ------------------------------------       ----------------------------------------       -------------------------------- 
    (Last)       (First)        (Middle)                                                                                 
                                           
    3205 Duvall
    ------------------------------------
                 (Street)

    Norman         OK          73072
    ------------------------------------
    (City)       (State)         (Zip)
      

4.  Statement for Month/Year    5.  If Amendment, Date of     6.  Relationship of Reporting Person to Issuer  
                                    Original (Month/Year)         (Check all applicable)                      
          11/97                                                                                                              
    ------------------------        ---------------------              Director                           10% Owner            
                                                                  ---                               ---                        
                                                                                                                               
                                                                   x   Officer (give title below)         Other (specify below)
                                                                  ---                               ---                        
                                                                        
7.  Individual or Joint/Group Filing (Check Applicable)           Controller/Secretary/Treasurer

            x   Form filed by One Reporting Person
           ---

                Form filed by More than One Reporting Person
           ---

- ------------------------------------------------------------------------------------------------------------------------------------
TABLE I -- NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
- ------------------------------------------------------------------------------------------------------------------------------------
1.  Title of Security            2.  Transaction Date         3.  Transaction Code              4.  Securities Acquired (A) or 
    (Instr. 3)                       (Month/Day/Year)             (Instr. 8)                        Disposed of (D) (Instr. 3, 4 
                                                                                                    and 5)
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                   Code      /     V              Amount / (A) or (D) / Price
- ------------------------------------------------------------------------------------------------------------------------------------
    Common Stock                     11/3/97                       P                              150          A        $8.00
- ------------------------------------------------------------------------------------------------------------------------------------
    Common Stock                     11/3/97                       P                              150          A        $8.00
- ------------------------------------------------------------------------------------------------------------------------------------
    Common Stock                     11/3/97                       P                              150          A        $8.00
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------------------------------------------
                                        5.  Amount of Securities     6.  Ownership Form:  Direct     7.   Nature of Indirect     
                                            Beneficially Owned           (D) or Indirect (I)              Beneficial Ownership
                                            at End of Month              (Instr. 4)                       (Instr. 4)
                                            (Instr. 3 and 4)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                     <C>                          <C>                             <C>
                                         150                         I                               By spouse
- ------------------------------------------------------------------------------------------------------------------------------------
                                         150                         I                               By self as custodian for
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                     Gilbert Carl Gibson 3
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                     Uniform Gifts to Minors Act
- ------------------------------------------------------------------------------------------------------------------------------------
                                         150                         I                               By self as custodian for
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                     Gregory Carlton Gibson
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                                                     Uniform Gifts to Minors Act
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.                   (Over)
* If the form filed by more than one reporting person, see Instruction 4(b)(v)                                       SEC 1474 (7/96)
</TABLE>
<PAGE>   2
FORM 4 (CONTINUED)

TABLE II -- DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
            (E.G., PUTS, CALLS, WARRANTS, OPTIONS, CONVERTIBLE SECURITIES)

<TABLE>
<CAPTION>
1. Title of Derivative  2. Conversion or   3. Transaction    4. Transaction      5. Number of Derivative   6. Date Exercisable and 
   Security (Instr. 3)     Exercise Price     Date (Month/      Code (Instr. 8)     Securities Acquired       Expiration Date   
                           of Derivative      Day/Year)                             (A) or Disposed of        (Month/Day/Year)
                           Security                                                 (D) (Instr. 3, 4,
                                                                                       and 5)
- ------------------------------------------------------------------------------------------------------------------------------------
                                                                Code   /   V           (A)    /   (D)      Date           Expiration
                                                                                                           Exercisable    Date
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                      <C>                <C>                 <C>        <C>         <C>        <C>      <C>            <C>
- ------------------------------------------------------------------------------------------------------------------------------------
Incentive Stock Options  $2.00              6/5/97              P                      20,000              (1)            6/5/07
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>



<TABLE>
<CAPTION>
                                 7.  Title and Amount      8.  Price of     9.  Number of      10.   Ownership      11.  Nature of
                                     of Underlying             Derivative       Derivative           Form of             Indirect
                                     Securities (Instr.        Security         Securities           Derivative          Beneficial
                                     3 and 4)                  (Instr. 5)       Beneficially         Security:           Ownership
                                                                                Owned at             Direct (D)          (Instr. 4)
                                                Amount or                       End of               or Indirect
                                                Number of                       Month                (I) (Instr. 4)
                                    Title       Shares                          (Instr. 4)  
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                              <C>            <C>             <C>              <C>                  <C>                  <C>
                                 Common Stock   20,000          (2)              20,000               D                    N/A
- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------

- ------------------------------------------------------------------------------------------------------------------------------------
</TABLE>
Explanation of Responses:
(1) Vest at a rate of 25% per year on each of June 5, 1998, June 5, 1999, June 
    5, 2000 and June 5, 2001.
(2) Issued pursuant to the terms of the Zymtex, Inc. Stock Option Plan in
consideration of Mr. Gibson's continuing employment by Zymtex, Inc. and the
mutual agreements of the parties to that certain Incentive Stock Option
Agreement dated effective June 5, 1997.

<TABLE>
<S>                                                                                       <C>
                                                                                                                  
** Intentional misstatements or omissions of facts constitute                             /s/ Gilbert Carl Gibson, Jr.    11/24/97
   Federal Criminal Violations.  See 18 U.S.C. 1001 and 15                                -----------------------------  ----------
   U.S.C. 78ff(a).                                                                        ** Signature of                   Date
                                                                                             Reporting Person

Note:  File three copies of this Form, one of which must
       be manually signed.  If space provided is insufficient,
       see Instruction 6 for procedure.                                                                                       
Potential persons who are to respond to the collection of information contained in this                                       Page 2
form are not required to respond unless the form displays the currently valid OMB Number.                            SEC 1474 (7/96)
</TABLE>

                  


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