ZYMETX INC
3, 1998-11-23
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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- --------       UNITED STATES SECURITIES AND EXCHANGE COMMISSION
 FORM 3                      WASHINGTON, D.C. 20549
- --------
            INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

   Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
      Section 17(a) of the Public Utility Holding Company Act of 1935 or
             Section 30(f) of the Investment Company Act of 1940

(Print or Type Responses)
<TABLE>
<S>                                        <C>                           <C>                                 <C>                 
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 1. Name and Address of Reporting Person*  2. Date of Event Requiring    4. Issuer Name and Ticker or        6. If Amendment, Date 
                                              Statement                     Trading Symbol                      of Original
    Salyer    Christopher      M.             (Month/Day/Year)              ZymeTx, Inc.   "ZMTX"               (Month/Day/Year)
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     (Last)     (First)     (Middle)              11/11/98               5. Relationship of Reporting        -----------------------
      722 N. Broadway, Ste. 500            ----------------------------      Person to Issuer                7. Individual or Joint/
- ----------------------------------------   3. I.R.S. Identification        (Check all applicable)               Group Filing (Check
             (Street)                         Number of Reporting          X   Director       10% Owner         Applicable Line)   
                                              Person, if an entity       -----           -----                   X  Form filed by 
  Oklahoma City     OK         73102          (voluntary)                      Officer        Other (specify    --- One Reporting
- --------------------------------------                                   -----           -----      below)          Person    
      (City)      (State)      (Zip)       ----------------------------  (give title below)                         Form filed by 
                                                                                                                --- More than One 
                                                                         ------------------------------             Reporting Person
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            TABLE I -- NON-DERIVATIVE SECURITIES BENEFICIALLY OWNED
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 1. Title of Security                         2. Amount of Securities         3. Ownership Form:         4. Nature of Indirect     
    (Instr. 4)                                   Beneficially Owned              Direct (D) or              Beneficial    
                                                 (Instr. 4)                      Indirect (I)               Ownership (Instr. 5)
                                                                                 (Instr. 5)                 
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Common stock, par value $.001 per share
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Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.                   (Over)
*If the form is filed by more than one reporting person, see Instruction 5(b)(v).                                    SEC 1473 (7-96)


           Potential persons who are to respond to the collection of information contained in this form are not required
                             to respond unless the form displays a currently valid OMB control number.
</TABLE>
<PAGE>   2
 
<TABLE>
<CAPTION>
 
FORM 3 (CONTINUED)               TABLE II -- DERIVATIVE SECURITIES BENEFICIALLY OWNED
                            (E.G., PUTS, CALLS, WARRANTS, OPTIONS, CONVERTIBLE SECURITIES)
 
<S>                              <C>                <C>                            <C>           <C>         <C>        
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1. Title of Derivative Security  2. Date            3. Title and Amount of         4. Conver-    5. Owner-   6. Nature of Indirect
   (Instr. 4)                       Exercisable and    Securities Underlying          sion or       ship        Beneficial Ownership
                                    Expiration Date    Derivative Security            Exercise      Form of     (Instr. 5)          
                                    (Month/Day/        (Instr. 4)                     Price of      Deriv-                         
                                    Year)                                             Deri-         ative                          
                                                                                      vative        Security:                      
                                                                                      Security      Direct                         
                                 -------------------------------------------------                  (D) or                         
                                 Date      Expira-                       Amount or                  Indirect (I)  
                                 Exercis-  tion             Title        Number                     (Instr. 5)             
                                 able      Date                          of Shares                                                 
                                                                                                                                   
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Non-qualified stock options       (1)    11/11/2008      Common Stock      25,000      $4.38          D                  N/A
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Explanation of Responses:

(1)  Vest at a rate of 3 1/3% per year on November 11, 1999, November 11, 2000 and November 11, 2001
 
                                                                                       /s/ CHRISTOPHER M. SALYER         11/23/98
**Intentional misstatements or omissions of facts constitute Federal Criminal        -------------------------------   -------------
  Violations.  See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).                             **Signature of Reporting Person        Date

Note. File three copies of this Form, one of which must be manually signed.                                           Page 2     
  If space is insufficient, see instruction 6 for procedure.                                             SEC 1473 (7-97)
                                                                                                                                 
</TABLE>

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB Number.


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