ZYMETX INC
S-3, EX-5.1, 2000-11-09
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                                     EXHIBIT 5.1

                                November 9, 2000


ZymeTx, Inc.
800 Research Parkway, Suite 100
Oklahoma City, OK 73104

         Re:     ZymeTx, Inc. (the "Company")
                 Form S-3 Registration Statement

Gentlemen:

         We have acted as counsel to the Company in connection with the
preparation of the Registration Statement on Form S-3 (the "Registration
Statement"), to be filed by the Company with the Securities and Exchange
Commission (the "Commission"), for the purpose of registering under the
Securities Act of 1933, as amended, an aggregate of 1,460,068 shares (the
"Shares") of the Company's common stock, $.001 par value (the "Common Stock"),
to be sold by a certain selling stockholders.

         Based on the foregoing, and assuming that the Registration Statement
becomes and remains effective during the period when the shares are offered and
sold and that all applicable securities laws are complied with, we are of the
opinion that the shares of Common Stock to be issued will be legally issued,
fully paid and nonassessable.

         We are members of the bar of the State of Oklahoma and do not hold
ourselves out as experts on, or as generally familiar with, or qualified to
express opinions under law other than the law of the State of Oklahoma, the
corporation law of the State of Delaware, and the law of the United States and
the opinion given herein is limited thereto.

                                            Very truly yours,

                                            PHILLIPS MCFALL MCCAFFREY MCVAY
                                                      & MURRAH, P.C.





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