<PAGE>
FILED PURSUANT TO
RULE 424 (b) (3) AND (c)
FILE NO. 333-38528
CV THERAPEUTICS, INC.
$196,250,000 PRINCIPAL AMOUNT
4 3/4% CONVERTIBLE SUBORDINATED NOTES DUE MARCH 7, 2007
AND
SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION OF THE NOTES
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This Prospectus Supplement relates to resales by selling security
holders of our 4 3/4% Convertible Subordinated Notes due March 7, 2007 and
shares of our common stock into which the notes are convertible.
This Prospectus Supplement should be read in conjunction with the
Prospectus dated June 29, 2000, (the "Prospectus") which is to be delivered with
this Prospectus Supplement.
SEE "RISK FACTORS" BEGINNING ON PAGE 7 OF THE PROSPECTUS TO READ ABOUT
FACTORS YOU SHOULD CONSIDER BEFORE BUYING THE NOTES OR OUR COMMON STOCK.
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Neither the Securities and Exchange Commission nor any other regulatory
body has approved or disapproved of these securities or passed upon the adequacy
or accuracy of this prospectus. Any representation to the contrary is a criminal
offense.
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The date of this Prospectus Supplement is December 15, 2000.
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The information in the table appearing in the Prospectus under the
heading "Selling Security Holders" is superseded by the information appearing in
the following table:
<TABLE>
<CAPTION>
PRINCIPAL AMOUNT COMMON STOCK
OF NOTES ISSUABLE NOTES OWNED COMMON STOCK
BENEFICIALLY UPON COMMON AFTER OWNED AFTER
OWNED AND CONVERSION STOCK COMPLETION COMPLETION
NAME OFFERED(1) OF THE NOTES OFFERED OF OFFERING OF OFFERING
------------------------------------------ ---------------- ------------ ------- ----------- ------------
<S> <C> <C> <C> <C> <C>
AAM/Zazove Institutional Income Fund,
L.P. $ 650,000 10,181 10,181 0 0
ABN AMRO Incorporated 1,000,000 15,664 15,664 0 0
Aftra Health Fund 750,000 11,748 11,748 0 0
AL-Bank AL-Saudi AL-Alami Saudi
International Bank 750,000 11,748 11,748 0 0
AIG SoundShore Holdings Ltd. 2,520,000 39,473 39,473 0 0
AIG SoundShore Opportunity Holding
Fund Ltd. 3,410,000 53,414 53,414 0 0
AIG SoundShore Strategic Holding Fund
Ltd. 977,000 15,303 15,303 0 0
Alta Partners Holdings, LDC 4,500,000 70,488 70,488 0 0
Argent Classic Convertible Arbitrage
Fund L.P. 2,500,000 39,160 39,160 0 0
Argent Classic Convertible Arbitrage
Fund (Bermuda) L.P. 3,000,000 46,992 46,992 0 0
Arthur D. Little Employee Investment
Fund 700,000 10,964 10,964 0 0
Aventis Pension Master Trust 149,000 2,333 2,333 0 0
Bancroft Convertible Fund, Inc. 250,000 3,916 3,916 0 0
The Bank of New York, as Trustee 1,100,000 17,230 17,230 0 0
The Bank of New York, Trustee for
Mark T. Ewing 50,000 783 783 0 0
Bankers Trust Co. Trustee for
DaimlerChrysler Corp. Emp.#1
Pension Plan dtd 4/1/89 4,470,000 70,018 70,018 0 0
Bear Stearns & Co., Inc. 1,000,000 15,664 15,664 0 0
BNP Arbitrage SNC 11,250,000 176,221 176,221 0 0
BNP Cooper Neff Convertible
Strategies Fund, L.P. 750,000 11,748 11,748 0 0
Boilermaker-Blacksmith Pension Trust 870,000 13,627 13,627 0 0
Boulder II Limited 1,500,000 23,496 23,496 0 0
Brown & Williamson Tobacco Master
Retirement Trust 250,000 3,916 3,916 0 0
CALAMOS Convertible Fund - CALAMOS
Investment Trust 1,100,000 17,230 17,230 0 0
CALAMOS Convertible Portfolio -
CALAMOS Advisors Trust 25,000 391 391 0 0
CALAMOS Global Growth and Income Fund
- CALAMOS Investment Trust 160,000 2,506 2,506 0 0
CALAMOS Growth and Income Fund -
CALAMOS Investment Trust 620,000 9,711 9,711 0 0
2
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PRINCIPAL AMOUNT COMMON STOCK
OF NOTES ISSUABLE NOTES OWNED COMMON STOCK
BENEFICIALLY UPON COMMON AFTER OWNED AFTER
OWNED AND CONVERSION STOCK COMPLETION COMPLETION
NAME OFFERED(1) OF THE NOTES OFFERED OF OFFERING OF OFFERING
------------------------------------------ ---------------- ------------ ------- ----------- ------------
Champion International Corporation
Master Retirement Trust 400,000 6,265 6,265 0 0
City of Albany Pension Plan 85,000 1,331 1,331 0 0
City of Knoxville Pension System 200,000 3,132 3,132 0 0
The Common Fund FAO Absolute Return
Fund 400,000 6,265 6,265 0 0
Credit Suisse First Boston Corporation 7,200,000 112,781 112,781 0 0
DeepRock & Co. 715,000 11,199 11,199 0 0
Delta Airlines Master Trust 1,600,000 25,062 25,062 0 0
Deutsche Bank Securities, Inc. 18,440,000 288,847 288,847 0 0
Diane D. Goodrich 50,000 783 783 0 0
Donaldson, Lufkin & Jenrette
Securities Corp. 3,450,000 54,041 54,041 0 0
Douglas D. Duke 25,000 391 391 0 0
The Dow Chemical Company Employees'
Retirement Plan 1,700,000 26,629 26,629 0 0
Duckbill & Co. 1,285,000 20,128 20,128 0 0
Ellsworth Convertible Growth and
Income Fund, Inc. 250,000 3,916 3,916 0 0
The Fondren Foundation 55,000 861 861 0 0
Franklin and Marshall College 330,000 5,169 5,169 0 0
Greek Catholic Union II 10,000 156 156 0 0
Hare and Company (nominee for the
Bank of New York as investment
advisor) 235,000 3,681 3,681 0 0
Hare and Company (nominee for the
Bank of New York as trustee) 1,100,000 17,230 17,230 0 0
Helix Convertible Opportunities Fund
Ltd. 1,230,000 19,226 19,266 0 0
Helix Convertible Opportunities L.P. 2,370,000 37,124 37,124 0 0
Hull Overseas, Ltd. 500,000 7,832 7,832 0 0
JP Morgan Securities, Inc. 5,625,000 88,110 88,110 0 0
James H. Hamersley Rev. Trust UA
6/23/99 30,000 469 469 0 0
Julius Baer Securities 650,000 10,181 10,181 0 0
KBC Financial Products 3,000,000 46,992 46,992 0 0
Kettering Medical Center Funded
Depreciation Account 55,000 861 861 0 0
Knoxville Utilities Board Retirement
System 140,000 2,192 2,192 0 0
Lipper Convertibles, L.P. 11,000,000 172,306 172,306 0 0
Lord Abbott Bond Debenture Fund 2,000,000 31,328 31,328 0 0
Mainstay Convertible Fund 2,000,000 31,328 31,328 0 0
Mainstay Strategic Value Fund 200,000 3,132 3,132 0 0
3
<PAGE>
PRINCIPAL AMOUNT COMMON STOCK
OF NOTES ISSUABLE NOTES OWNED COMMON STOCK
BENEFICIALLY UPON COMMON AFTER OWNED AFTER
OWNED AND CONVERSION STOCK COMPLETION COMPLETION
NAME OFFERED(1) OF THE NOTES OFFERED OF OFFERING OF OFFERING
------------------------------------------ ---------------- ------------ ------- ----------- ------------
Merrill Lynch, Pierce, Fenner &
Smith, Incorporated 18,409,000 288,358 288,358 0 0
Michael FT Maude Discretionary Trust 10,000 156 156 0 0
Morgan Stanley Dean Witter
Convertible Securities Trust 1,500,000 23,496 23,496 0 0
New York Life Separate Account #7 1,500,000 23,496 23,496 0 0
Norwalk Employees Pension Plan 800,000 12,531 12,531 0 0
Onex Industrial Partners Limited 2,500,000 39,160 39,160 0 0
Pebble Capital Inc. 1,000,000 15,664 15,664 0 0
Pell Rudman Trust Company 1,720,000 26,942 26,942 0 0
Penn Treaty Network America Insurance
Company 440,000 6,892 6,892 0 0
Port Authority of Allegheny County
Retirement and Disability
Allowance Plan for the Employees
Represented by Local 85 of the
Amalgamated Transit Union 835,000 13,079 13,079 0 0
President and Fellows of Harvard
College 4,000,000 62,656 62,656 0 0
R2 Investments, LDC 42,000,000 657,894 657,894 0 0
Robertson Stephens 2,500,000 39,160 39,160 0 0
RS Midcap Opportunities Fund 1,000,000 15,664 15,664 0 0
San Diego County Employees Retirement
Association 1,253,750 19,638 19,638 0 0
Silvercreek Limited Partnership 1,000,000 15,664 15,664 0 0
SPT 650,000 10,181 10,181 0 0
State Street Bank Custodian for GE
Pension Trust 2,365,000 37,045 37,045 0 0
The Sylvan C. Coleman Foundation 70,000 1,096 1,096 0 0
Tribeca Investments LLC 38,495,000 602,991 602,991 0 0
Unifi, Inc. Profit Sharing Plan and
Trust 90,000 1,409 1,409 0 0
United Capital Management, Inc. 250,000 3,916 3,916 0 0
United Food and Commercial Workers
Local 1262 and Employers Pension
Fund 225,000 3,524 3,524 0 0
Van Waters & Rogers, Inc. Retirement
Plan (f.k.a. Univar Corporation) 260,000 4,072 4,072 0 0
White River Securities, LLC 1,000,000 15,664 15,664 0 0
Zurich HFR Master Hedge Fund Index
Ltd. 200,000 3,132 3,132 0 0
</TABLE>
4
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(1) Amounts indicated may be in excess of the total amount registered due
to sales or transfers exempt from the registration requirements of the
Securities Act since the date upon which the selling holders provided
to us the information regarding their notes.
5
