<PAGE> 1
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Form 13F
Form 13F COVER PAGE
Report for Calendar Year or Quarter Ended: March 31, 1998
Check here if Amendment [ X ]; Amendment Number: 1
This Amendment (Check only one.): [ X ] is a restatement.
[ ] adds new holdings entries.
Institutional Investment Manager Filing this Report:
Name: BB Biotech AG
Address: Vordergasse 3
Grafenauweg 4
Zug, Switzerland CH-6301
Form 13F File Number: 28-6964
The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables are considered integral parts of this form.
Person Signing this Report on Behalf of Reporting Manager:
Name: Daniel Bugmann
Title: SIGNING AUTHORITY
----------------
Phone: (41-41) 724-5959
Signature, Place, and Date of Signing:
/s/ DANIEL BUGMANN Zug, Switzerland, 18 May 1999
- -------------------- ----
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Report Type (Check only one.):
[ ] 13F HOLDINGS REPORT. (Check here if all holdings of this reporting
manager are reported in this report.)
[ ] 13F NOTICE. (Check here if no holdings reported are in this report,
and all holdings are reported by other reporting manager(s).)
[XX] 13F COMBINATION REPORT. (Check here if a portion of the holdings for
this reporting manager are reported in this report and a portion are
reported by other reporting manager(s).)
List of Other Managers Reporting for this Manager:
Name
Biotech Invest S.A.
Biotech Target S.A.
-2-
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Form 13F SUMMARY PAGE
Report Summary:
Number of Other Included Managers: 2
Form 13F Information Table Entry Total: 15
Form 13F Information Table Value Total:$697,804
(thousands)
List of Other Included Managers:
Provide a numbered list of the name(s) and Form 13F file number(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.
No. Name
1 Biotech Invest S.A.
2 Biotech Target S.A.
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BB BIOTECH AG
31-MAR-98 FORM 13F INFORMATION TABLE
<TABLE>
<CAPTION>
- ----------------------------------------------------------------------------------------------------------------
COLUMN 5:
------------------------------------
COLUMN 4:
COLUMN 1: COLUMN 2: COLUMN 3: VALUE
NAME OF ISSUER TITLE OF CLASS CUSIP (X$1,000) SHRS OR SH/ PUT/
PRN AMT PRN CALL
- ----------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C> <C>
Alexion Common Stock 01535110 $ 22,583 1,824,113 SH
Pharmaceuticals
Inc.
- ----------------------------------------------------------------------------------------------------------------
Ariad Common Stock 04033A10 $ 11,922 2,575,000 SH
Pharmaceuticals
Inc.
- ----------------------------------------------------------------------------------------------------------------
Aurora Common Stock 05192010 $ 16,347 1,421,500 SH
Biosciences,
Inc.
- ----------------------------------------------------------------------------------------------------------------
Aviron Common Stock 05376210 $ 61,417 2,655,286 SH
- ----------------------------------------------------------------------------------------------------------------
Common Stock 09058T10 $ 166,609 6,887,500 SH
Biochem
Pharma,
Inc.
- ----------------------------------------------------------------------------------------------------------------
CV Common Stock 12666710 $ 18,712 1,969,647 SH
Therapeutics,
Inc.
- ----------------------------------------------------------------------------------------------------------------
Genzyme Common Stock 37291710 $ 21,920 685,000 SH
Corporation
- ----------------------------------------------------------------------------------------------------------------
Gilead Common Stock 37555810 $ 15,966 443,500 SH
Sciences, Inc.
- ----------------------------------------------------------------------------------------------------------------
La Jolla Common Stock 50345910 $ 11,721 3,021,000 SH
Pharmaceutical
Company
- ----------------------------------------------------------------------------------------------------------------
MedImmune, Common Stock 58469910 $ 193,947 3,518,000 SH
Inc.
- ----------------------------------------------------------------------------------------------------------------
Millennium Common Stock 59990210 $ 4,089 219,500 SH
Pharmaceuticals,
Inc.
- ----------------------------------------------------------------------------------------------------------------
Sugen, Inc. Common Stock 86504110 $ 7,278 534,000 SH
- ----------------------------------------------------------------------------------------------------------------
Synsorb Common Stock 87160V10 $ 14,332 1,979,510 SH
Biotech, Inc.
- ----------------------------------------------------------------------------------------------------------------
<CAPTION>
- ------------------------------------------------------------------------------------------
COLUMN 8:
COLUMN 6: COLUMN 7: VOTING AUTHORITY
INVESTMENT OTHER MANAGERS --------------------------------
COLUMN 1: DISCTRETION
NAME OF ISSUER SOLE SHARED NONE
- ------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C>
Alexion DEFINED 2 1,824,113 NONE NONE
Pharmaceuticals
Inc.
- ------------------------------------------------------------------------------------------
Ariad DEFINED 2 2,575,000 NONE NONE
Pharmaceuticals
Inc.
- ------------------------------------------------------------------------------------------
Aurora DEFINED 2 1,421,500 NONE NONE
Biosciences,
Inc.
- ------------------------------------------------------------------------------------------
Aviron DEFINED 2 2,655,286 NONE NONE
- ------------------------------------------------------------------------------------------
DEFINED 1 6,887,500 NONE NONE
Biochem
Pharma,
Inc.
- ------------------------------------------------------------------------------------------
CV DEFINED 2 1,969,647 NONE NONE
Therapeutics,
Inc.
- ------------------------------------------------------------------------------------------
Genzyme DEFINED 1 685,000 NONE NONE
Corporation
- ------------------------------------------------------------------------------------------
Gilead DEFINED 2 3,021,000 NONE NONE
Sciences, Inc.
- ------------------------------------------------------------------------------------------
La Jolla DEFINED 2 #REF! NONE NONE
Pharmaceutical
Company
- ------------------------------------------------------------------------------------------
MedImmune, DEFINED 2 3,518,000 NONE NONE
Inc.
- ------------------------------------------------------------------------------------------
Millennium DEFINED 219,500 NONE NONE
Pharmaceuticals,
Inc.
- ------------------------------------------------------------------------------------------
Sugen, Inc. DEFINED 2 534,000 NONE NONE
- ------------------------------------------------------------------------------------------
Synsorb DEFINED 2 1,979,510 NONE NONE
Biotech, Inc.
- ------------------------------------------------------------------------------------------
</TABLE>
<PAGE> 5
<TABLE>
<S> <C> <C> <C> <C> <C>
- ---------------------------------------------------------------------------------------------------------------
Transkaryotic Common Stock 89373510 $ 91,036 2,811,500 SH
Therapies,
Inc.
- ---------------------------------------------------------------------------------------------------------------
Vertex Common Stock 92532F10 $ 39,925 1,250,000 SH
Pharmaceuticals,
Inc.
- ---------------------------------------------------------------------------------------------------------------
COLUMN $ 697,804
TOTALS
- ---------------------------------------------------------------------------------------------------------------
</TABLE>
<TABLE>
<S> <C> <C> <C> <C> <C>
- ---------------------------------------------------------------------------------------------
Transkaryotic DEFINED 2 2,811,500 NONE NONE
Therapies,
Inc.
- ---------------------------------------------------------------------------------------------
Vertex DEFINED 1 1,250,000 NONE NONE
Pharmaceuticals,
Inc.
- ---------------------------------------------------------------------------------------------
COLUMN
TOTALS
- ---------------------------------------------------------------------------------------------
</TABLE>
