RIBOGENE INC / CA/
SC 13D, 1998-07-02
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934

                                 Ribogene, Inc.
                                (Name of Issuer)

                     Common Stock, par value $.001 per share
                         (Title of Class of Securities)

                                    762565109
                                 (CUSIP Number)


                    Paramount Capital Asset Management, Inc.
                         c/o Lindsay A. Rosenwald, M.D.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4300
                                 with a copy to:

                              David R. Walner, Esq.
                    Paramount Capital Asset Management, Inc.
                               787 Seventh Avenue
                               New York, NY 10019
                                 (212) 554-4372

         (Name,  Address and  Telephone  Number of Person  Authorized to Receive
Notices and Communications)

                                  June 2, 1998/1/
             (Date of Event which Requires Filing of this Statement)



If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which  is the  subject  of  this  Statement  because  of  Rule
13d-1(b)(3) or (4), check the following:
                                                                         [_]
Check the following box if a fee is being paid with this Statement:
                                                                         [_]

- ----------

/1/ On June 2, 1998 the Issuer closed an Initial Public Offering.


                                        1

<PAGE>

CUSIP No.  [762565109]                                     
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Paramount Capital Asset Management, Inc.         
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    [_]
                                                          (b)    [_]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          755,570
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        755,570
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         755,570
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         13.6%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         CO
- --------------------------------------------------------------------------------
                                        2

<PAGE>


CUSIP No.  [762565109]                                     
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Aries Domestic Fund, L.P.
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    [_]
                                                          (b)    [_]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          268,227
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        268,227
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         268,227
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         4.9%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         PN
- --------------------------------------------------------------------------------
                                        3

<PAGE>


CUSIP No.  [762565109]                                     
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         The Aries Trust
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    [_]
                                                          (b)    [_]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         Cayman Islands
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             None
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          487,343
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        None
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        487,343
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         487,343
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         8.8%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         OO (see Item 2)
- --------------------------------------------------------------------------------
                                        4

<PAGE>


CUSIP No.  [762565109]                                     
- --------------------------------------------------------------------------------
1)       NAME OF REPORTING PERSON
         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
         
         Lindsay A. Rosenwald, M.D.
- --------------------------------------------------------------------------------
2)       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)    [_]
                                                          (b)    [_]
- --------------------------------------------------------------------------------
3)       SEC USE ONLY

- --------------------------------------------------------------------------------
4)       SOURCE OF FUNDS*
         00 (see Item 3 below)
- --------------------------------------------------------------------------------
5)       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED
         PURSUANT TO ITEMS 2(d) OR 2(e)                          [_]
- --------------------------------------------------------------------------------
6)       CITIZENSHIP OR PLACE OF ORGANIZATION
         United States
- --------------------------------------------------------------------------------
                   7)   SOLE VOTING POWER
                  
  NUMBER OF             480,378
    SHARES        --------------------------------------------------------------
 BENEFICIALLY      8)   SHARED VOTING POWER
   OWNED BY         
EACH REPORTING          755,570
    PERSON        --------------------------------------------------------------
     WITH          9)   SOLE DISPOSITIVE POWER
                         
                        480,378
                  --------------------------------------------------------------
                  10)   SHARED DISPOSITIVE POWER
                    
                        755,570
- --------------------------------------------------------------------------------
11)      AGGREGATE  AMOUNT  BENEFICIALLY  OWNED BY EACH REPORTING PERSON 
         1,235,948
- --------------------------------------------------------------------------------
12)      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                  [_]
- --------------------------------------------------------------------------------
13)      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
         20.5%
- --------------------------------------------------------------------------------
14)      TYPE OF REPORTING PERSON*
         IN
- --------------------------------------------------------------------------------


                                        5

<PAGE>


Item 1.  Security and Issuer.

     (a)  Common Stock, $.001 par value ("Shares")

          Ribogene, Inc. (the "Issuer")
          26118 Research Road
          Hayward, CA 94545
          (510) 732-5551

Item 2.  Identity and Background.

      Names of Persons Filing:

     (a)  This  statement  is  filed  on  behalf  of  Paramount   Capital  Asset
          Management,  Inc.  ("Paramount  Capital"),  Aries Domestic Fund,  L.P.
          ("Aries  Domestic"),  The Aries Trust  ("Aries  Trust") and Lindsay A.
          Rosenwald,   M.D.  ("Dr.   Rosenwald"  and  collectively,   "Reporting
          Parties").  See attached  Exhibit A which is a copy of their agreement
          in writing to file this statement on behalf of each of them.

     (b)  Paramount  Capital's,  Aries Domestic's and Dr.  Rosenwald's  business
          address is 787 Seventh Avenue,  48th Floor, New York, New York, 10019.
          The  business  address  for Aries  Trust is c/o  MeesPierson  (Cayman)
          Limited,  P.O. Box 2003,  British American Centre,  Phase 3, Dr. Roy's
          Drive, George Town, Grand Cayman.

     (c)  Dr.  Rosenwald  is an  investment  banker,  venture  capitalist,  fund
          manager and sole  shareholder of Paramount  Capital,/2/ a Subchapter S
          corporation incorporated in Delaware. Paramount Capital is the General
          Partner of Aries  Domestic,/3/ a limited  partnership  incorporated in
          Delaware.  Paramount  Capital  is  the  Investment  Manager  to  Aries
          Trust,/4/ a Cayman Islands Trust.

     (d)  Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Trust and
          their respec tive officers,  directors,  general partners,  investment
          managers,  or  trustees  have not,  during the five years prior to the
          date  hereof,  been  convicted  in a  criminal  proceeding  (excluding
          traffic violations or similar misdemeanors).

     (e)  Dr. Rosenwald,  Paramount Capital,  Aries Domestic and Aries Trust and
          their respective  officers,  directors,  general partners,  investment
          managers,  or trustees  have not been,  during the five years prior to
          the date  hereof,  parties  to a civil  proceeding  of a  judicial  or
          administrative  body of competent  jurisdiction,  as a result of which
          such  person was or is subject to a  judgment,  decree or final  order
          enjoining future violations of, or prohibiting or mandating activities
          subject to, Federal or State  securities laws or finding any violation
          with respect to such laws.

     (f)  Dr. Rosenwald is a citizen of the United States.

- --------
  
    /2/   Please see attached  Exhibit B indicating  the executive  officers and
          directors of Paramount Capital and providing information called for by
          Items 2-6 of this statement as to said officers and directors. Exhibit
          B is herein incorporated by reference.

    /3/   Please see attached  Exhibit C indicating the general partner of Aries
          Domestic and the general  partner's  executive  officers and directors
          and providing information called for by Items 2-6 of this statement as
          to said general partners, officers and directors.  Exhibit C is herein
          incorporated by reference.

    /4/   Please see attached Exhibit D indicating the investment manager of the
          Aries Trust and the investment  manager's executive officers and direc
          tors  and  providing  information  called  for by  Items  2-6 of  this
          statement as to said  investment  manager and officers and  directors.
          Exhibit D is herein incorporated by reference.

                                        6

<PAGE>

 
Item 3.   Source and Amount of Funds or Other Consideration.

          The Issuer completed a private placement (the "Private  Placement") of
          the Issuer's  securities on June 23, 1997, in which Aries Domestic and
          Aries Trust used $617,699 and $1,122,301 of their  respective  general
          funds to purchase  units of the Issuer  consisting,  respectively,  of
          315,555 and 573,334 shares of Series F Preferred Stock (the "Preferred
          Stock")  and 315,555 and  573,334  Class A Warrants  convertible  into
          202,870 and 368,596 and  exercisable  for 22,530 and 40,936  shares of
          Common  Stock of the  Issuer,  respectively.  In  connection  with the
          initial public offering of the Issuer's  securities  completed on June
          2, 1998, the Preferred Stock was  automatically  converted into Common
          Stock. In connection with the Private  Placement,  Paramount  Capital,
          Inc.  (the  "Placement  Agent"),  designated  recipients of options to
          purchase units exercisable for ten years at 110% of the offering price
          per unit sold in the Private Placement (the "Placement Options").  The
          Placement  Agent  designated  The Aries Trust,  Aries Domestic and Dr.
          Rosenwald, Placement Options to purchase units exercisable for 73,718,
          40,574 and  455,106  shares of Common  Stock  respectively  and 4,093,
          2,253 and 25,272 Warrants respectively).

Item 4.   Purpose of Transaction.

          The Reporting  Parties acquired shares of Preferred Stock and Warrants
          of the Issuer as an investment in the Issuer.

          Although the  Reporting  Parties have not  formulated  any  definitive
          plans, they may from time to time acquire, or dispose of, Common Stock
          and/or  other  securities  of the  Issuer  if and  when  they  deem it
          appropriate. The Reporting Parties may formulate other purposes, plans
          or proposals  relating to any of such  securities of the Issuer to the
          extent  deemed  advisable  in light of market  conditions,  investment
          policies and other factors.

          Except as  indicated  in this  Schedule  13D,  the  Reporting  Parties
          currently have no plans or proposals that relate to or would result in
          any of the matters  described in subparagraphs (a) through (j) of Item
          4 of Schedule 13D.

Item 5.   Interest in Securities of the Issuer.

     (a)  As of June 2, 1998,  Paramount  Capital,  through  acquisition  of the
          shares by the  Aries  Trust and  Aries  Domestic  described  in Item 3
          above,  beneficially  owned  755,570  shares or 13.6% of the  Issuer's
          securities and Aries Domestic and the Aries Trust  beneficially  owned
          as follows:

                                             Amount Owned
          Aries Domestic                     268,227 Shares
          Aries Trust                        487,343 Shares

          As of June 2, 1998, Dr.  Rosenwald  through his  acquisition of shares
          described in Item 3 above and the  acquisition  of shares by the Aries
          Trust and Aries Domestic described in Item 3 above, beneficially owned
          1,235,948 shares or 20.5% of the Issuer's securities.

     (b)  Dr.  Rosenwald  and  Paramount  Capital  share the power to vote or to
          direct the vote,  to dispose  or to direct  the  disposition  of those
          shares owned by each of Aries Domestic and Aries Trust.

     (c)  No open market transactions were made by Dr. Rosenwald, Aries Domestic
          or the Aries Trust in the past 60 days.

          Other than as set forth herein the Reporting  Parties have not engaged
          in any  transactions  in the Common Stock of the Issuer since the last
          filing.

     (d)  & (e) Not applicable.

Item 6.   Contracts, Arrangements, Understandings or Relationships
          with respect to Securities of the Issuer

          Paramount Capital is the investment manager of the Aries Trust and the
          General  Partner  of Aries  Domestic  and in such  capacities  has the
          authority to make certain

                                        7

<PAGE>


          investment  decisions on behalf of such entities,  including decisions
          relating to the  securities  of the  Issuer.  In  connection  with its
          investment  management  duties,  Paramount  Capital  receives  certain
          management fees and performance  allocations  from the Aries Trust and
          Aries  Domestic.  Dr.  Rosenwald is the sole  shareholder of Paramount
          Capital.  Except as  indicated in this 13D and  exhibits,  there is no
          contract,  arrangement,  understanding  or  relationship  between  the
          Reporting Parties and any other person, with respect to any securities
          of the Issuer.

Item 7.   Material to be Filed as Exhibits:

Exhibit A -    Copy of an  Agreement  between  Dr.  Rosenwald,  Paramount
               Capital, Aries Domestic and Aries Trust to file this Statement
               on Schedule 13D on behalf of each of them.

Exhibit B -    List of  executive  officers  and  directors  of Paramount
               Capital  and  information  called  for by  Items  2-6 of  this
               statement relating to said officers and directors.

Exhibit C -    List of executive officers and directors of Aries Domestic
               and  information  called  for by Items  2-6 of this  statement
               relating to said officers and directors.

Exhibit  D -   List of executive  officers  and  directors of Aries Trust
               and  information  called  for by Items  2-6 of this  statement
               relating to said officers and directors.

                                        8

<PAGE>

                                   SIGNATURES


         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   July 1, 1998
         New York, NY             By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      President


                                   ARIES DOMESTIC FUND, L.P.
                                   By: Paramount Capital Asset Management, Inc.
                                       General Partner

Dated:   July 1, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


                                   THE ARIES TRUST
                                   By: Paramount Capital Asset Management, Inc.
                                       Investment Manager

Dated:   July 1, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


Dated:   July 1, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13D

                  The undersigned  hereby agree to jointly prepare and file with
regulatory  authorities  a  Schedule  13D  and  any  future  amendments  thereto
reporting  each  of  the  undersigned's  ownership  of  securities  of  Repligen
Corporation,  and hereby  affirm that such Schedule 13D is being filed on behalf
of each of the undersigned.

                                  PARAMOUNT CAPITAL ASSET MANAGEMENT, INC.

Dated:   July 1, 1998
         New York, NY             By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                      Lindsay A. Rosenwald, M.D.
                                      President


                                   ARIES DOMESTIC FUND, L.P.
                                   By: Paramount Capital Asset Management, Inc.
                                       General Partner

Dated:   July 1, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.

                                       9

<PAGE>

                                       President

                                   THE ARIES TRUST
                                   By: Paramount Capital Asset Management, Inc.
                                       Investment Manager

Dated:   July 1, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.
                                       President


Dated:   July 1, 1998
         New York, NY              By: /s/ Lindsay A. Rosenwald, M.D.
                                     ------------------------------------------
                                       Lindsay A. Rosenwald, M.D.

                                       10

<PAGE>


                                               EXHIBIT B

         The name and principal occupation or employment, which in each instance
is with Paramount Capital Asset Management,  Inc. ("Paramount  Capital") located
at 787 Seventh Avenue,  48th Floor, New York, New York, 10019, of each executive
officer and director of Paramount Capital is as follows:

                                         PRINCIPAL OCCUPATION
         NAME                               OR EMPLOYMENT

Lindsay A. Rosenwald, M.D.      Chairman of the Board, President of Paramount
                                Capital Asset Management, Inc., Paramount
                                Capital Investments, LLC and Paramount
                                Capital, Inc.

Peter Morgan Kash               Director of Paramount Capital Asset
                                Management, Inc., Senior Managing Director,
                                Paramount Capital, Inc.

Dr. Yuichi Iwaki                Director of Paramount Capital Asset
                                Management, Inc., Professor, University of
                                Southern California School of Medicine


Item 2.

         During  the five  years  prior to the date  hereof,  none of the  above
persons  (to the best of  Paramount  Capital's  knowledge)  was  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.


                                       11

<PAGE>


                                    EXHIBIT C

         The name and principal  occupation or  employment,  which is located at
787  Seventh  Avenue,  48th Floor,  New York,  New York,  10019,  of the General
Partner of Aries Domestic is as follows:

                                                   PRINCIPAL OCCUPATION
         NAME                                         OR EMPLOYMENT

Paramount Capital Asset Management, Inc.     General Partner; Investment Manager

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years prior to the date  hereof,  the above  person (to
the best of Aries  Domestic's  knowledge)  has not been  convicted in a criminal
proceeding (excluding traffic violations or similar misdemeanors) or was a party
to a  civil  proceeding  of a  judicial  or  administrative  body  of  competent
jurisdiction,  as a result of which such person was or is subject to a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, Federal or State securities laws or finding any
violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.

                                       12

<PAGE>


                                    EXHIBIT D

         The name and principal occupation or employment, which in each instance
is with The Aries Trust  ("Aries  Trust")  located at 787 Seventh  Avenue,  48th
Floor,  New York, New York,  10019,  of each  executive  officer and director of
Aries Trust is as follows:

                                                        PRINCIPAL OCCUPATION
         NAME                                              OR EMPLOYMENT

Paramount Capital Asset Management, Inc.             Investment Manager

MeesPierson (Cayman) Limited                         Trustee

         Exhibit B is hereby incorporated by reference.

Item 2.

         During the five years  prior to the date  hereof,  neither of the above
persons  (to the best of Aries  Trust's  knowledge)  have  been  convicted  in a
criminal  proceeding  (excluding traffic violations or similar  misdemeanors) or
was a party  to a civil  proceeding  of a  judicial  or  administrative  body of
competent jurisdiction,  as a result of which such person was or is subject to a
judgment,  decree or final order enjoining future  violations of, or prohibiting
or mandating  activities subject to, Federal or State securities laws or finding
any violation with respect to such laws.

Items 3-6.

         Please refer to Items 3-6 herein reporting the beneficial ownership.

                                       13



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