ALGOS PHARMACEUTICAL CORP
DEF 14A, 1997-05-14
PHARMACEUTICAL PREPARATIONS
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                            SCHEDULE 14A INFORMATION
Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934
Filed by the Registrant [x]
Filed by a Party other than the Registrant [ ]
Check the appropriate box:
[ ]     Preliminary Proxy Statement
[ ]     Confidential, for Use of the Commission Only (as permitted by
        Rule 14a-6(e)(2))
[x]     Definitive Proxy Statement
[ ]     Definitive Additional Materials
[ ]     Soliciting Material Pursuant to 'SS' 240.14a-11(c) or 'SS' 240.14a-12

- --------------------------------------------------------------------------------
                        Algos Pharmaceutical Corporation
- --------------------------------------------------------------------------------

Payment of Filing Fee (Check the appropriate box):

[x]     No fee required.

[ ]     Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

        1)   Title of each Class of securities to which transaction applies:

        ------------------------------------------------------------------------

        2)   Aggregate number of securities to which transaction applies:

        ------------------------------------------------------------------------

        3)   Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the filing fee
is calculated and state how it was determined):

        ------------------------------------------------------------------------

        4)   Proposed maximum aggregate value of transaction:

        ------------------------------------------------------------------------

        5)   Total fee paid:

        ------------------------------------------------------------------------

[ ]     Fee paid previously with preliminary materials.

[ ]     Check box if any part of the fee is offset as provided by Exchange Act
Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid
previously. Identify the previous filing by registration statement number, or
the Form or Schedule and the date of its filing.

        1)   Amount Previously Paid:

        ------------------------------------------------------------------------

        2)   Form, Schedule or Registration Statement No.:

        ------------------------------------------------------------------------

        3)   Filing Party:

        ------------------------------------------------------------------------

        4)   Date Filed:

        ------------------------------------------------------------------------



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<PAGE>
                        ALGOS PHARMACEUTICAL CORPORATION
                               COLLINGWOOD PLAZA
                                 4900 ROUTE 33
                           NEPTUNE, NEW JERSEY 07753
 
Dear Stockholder:
 
     You are cordially invited to attend the Annual Meeting of Stockholders (the
'1997   Annual  Meeting')  of  ALGOS   PHARMACEUTICAL  CORPORATION,  a  Delaware
corporation ('Algos'), to  be held  on Tuesday, June  10, 1997,  at 10:00  a.m.,
local time at the Sheraton Eatontown Hotel & Conference Center, 6 Industrial Way
East, Eatontown, New Jersey 07724.
 
     At the 1997 Annual Meeting, you will be asked to consider and vote upon the
following  matters,  all  of  which   are  described  more  completely  in   the
accompanying Proxy Statement:
 
          1.  To elect two persons  to Algos' Board of  Directors to serve for a
     term of  three years  and until  the election  and qualification  of  their
     respective successors; and
 
          2.  To transact  such other business  as may properly  come before the
     1997 Annual Meeting and any adjournments or postponements thereof.
 
     THE BOARD  OF DIRECTORS  UNANIMOUSLY  RECOMMENDS A  VOTE  FOR EACH  OF  THE
NOMINEES NAMED IN THE PROXY STATEMENT.
 
     Only  Stockholders of record  at the close  of business on  May 9, 1997 are
entitled to notice of and to vote at, the 1997 Annual Meeting.
 
     We urge you to  review carefully the Proxy  Statement and the  accompanying
appendices. We hope you will attend the 1997 Annual Meeting. However, whether or
not you plan to attend the 1997 Annual Meeting, it is important that your shares
are  represented. Accordingly, please complete, sign and date the enclosed proxy
and return it in the enclosed prepaid  envelope. If you are present at the  1997
Annual Meeting you may, if you wish, withdraw your proxy and vote in person.
 
                                          Very truly yours,


                                          JOHN W. LYLE
                                          Chief Executive Officer and President
 
May 13, 1997


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<PAGE>
                        ALGOS PHARMACEUTICAL CORPORATION
                               COLLINGWOOD PLAZA
                                 4900 ROUTE 33
                           NEPTUNE, NEW JERSEY 07753
 
                            ------------------------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                      TO BE HELD ON TUESDAY, JUNE 10, 1997
                            ------------------------

To the Stockholders of
ALGOS PHARMACEUTICAL CORPORATION:
 
     The  Annual Meeting  of Stockholders (the  '1997 Annual  Meeting') of ALGOS
PHARMACEUTICAL CORPORATION, a  Delaware corporation ('Algos'),  will be held  at
the  Sheraton  Eatontown  Hotel &  Conference  Center,  6  Industrial  Way East,
Eatontown, New Jersey  07724 on  Tuesday, June 10,  1997, at  10:00 a.m.,  local
time, for the following purposes:
 
          1.  To elect two persons  to Algos' Board of  Directors to serve for a
     term of  three years  and until  the election  and qualification  of  their
     respective successors; and
 
          2.  To transact  such other business  as may properly  come before the
     1997 Annual Meeting and any adjournments or postponements thereof.
 
     The election and other matters are more fully described in the accompanying
Proxy Statement and the appendices thereto, which form a part of this Notice.
 
     The Board of Directors of Algos has  fixed the close of business on May  9,
1997  as the  record date  (the 'Algos  Record Date')  for the  determination of
stockholders entitled to notice of and to vote at the 1997 Annual Meeting or any
adjournments or postponements thereof. Only stockholders of record at the  close
of  business on the Algos Record Date are entitled to notice of, and to vote at,
the 1997 Annual Meeting and any adjournments or postponements thereof.
 
     THE BOARD  OF DIRECTORS  UNANIMOUSLY  RECOMMENDS A  VOTE  FOR EACH  OF  THE
NOMINEES NAMED IN THE PROXY STATEMENT.
 
     Whether or not you plan to attend the 1997 Annual Meeting, please complete,
sign,  date and return promptly the enclosed form of proxy. A return envelope is
enclosed for your convenience and requires no postage for mailing in the  United
States.
 
                                          By Order of the Board of Directors,


                                          JAMES R. LEDLEY
                                          Assistant Secretary
 
May 13, 1997


<PAGE>
<PAGE>
                        ALGOS PHARMACEUTICAL CORPORATION
                               COLLINGWOOD PLAZA
                                 4900 ROUTE 33
                           NEPTUNE, NEW JERSEY 07753
 
                            ------------------------
                                PROXY STATEMENT
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 10, 1997
                            ------------------------
 
                                  INTRODUCTION
 
     This   Proxy  Statement   is  furnished   to  the   stockholders  of  Algos
Pharmaceutical  Corporation,  a   Delaware  corporation   (the  'Company'),   in
connection  with the solicitation of proxies on behalf of the Company's Board of
Directors (the 'Board of Directors') to be  voted at the 1997 Annual Meeting  of
Stockholders (the '1997 Annual Meeting') to be held on Tuesday, June 10, 1997 at
10:00 a.m., local time at  the Sheraton  Eatontown Hotel & Conference  Center, 6
Industrial Way East, Eatontown, New Jersey 07724 or at such other time and place
to which the 1997 Annual Meeting may be adjourned, for the purposes set forth in
the accompanying Notice of Meeting. This  Proxy Statement and Notice of  Meeting
and  the related proxy card are first  being mailed to stockholders beginning on
or about May 19,  1997. The Company's principal  executive office is located  at
Collingwood Plaza, 4900 Route 33, Neptune, New Jersey 07753.
 
                                  RECORD DATE
 
     The  Board of Directors has  fixed the close of business  on May 9, 1997 as
the  record  date  (the  'Record  Date')  for  the  1997  Annual  Meeting.  Only
stockholders  of record  on that  date are  entitled to  vote at  the meeting in
person or by proxy.
 
                                    PROXIES
 
     The proxies named on the enclosed proxy card were appointed by the Board of
Directors to vote the shares represented by the proxy card. Upon receipt by  the
Company  of  a properly  signed  and dated  proxy  card, the  shares represented
thereby will be voted in accordance with the instructions on the proxy card.  If
a  stockholder does not return a signed proxy  card, his or her shares cannot be
voted by proxy. Stockholders are  urged to mark the boxes  on the proxy card  to
show  how their shares are to be voted.  If a stockholder returns a signed proxy
card without marking the boxes, the shares represented by the proxy card will be
voted as recommended by the Board of Directors herein and on the proxy card, FOR
the election of the persons named under 'Election of Directors' as nominees  for
election  as Directors of  the Company (each a  'Nominee' and, collectively, the
'Nominees') for terms to expire on the  date of the third annual meeting of  the
Company's  stockholders following the  1997 Annual Meeting.  The proxy card also
confers discretionary authority on the proxies  to vote on any other matter  not
presently  known to the management that may  properly come before the meeting or
any adjournment thereof. Any  proxy delivered pursuant  to this solicitation  is
revocable  at the option of the person(s) executing the same (i) upon receipt by
the Company before the proxy is voted  of a duly executed proxy bearing a  later
date,  (ii) by written  notice of revocation  to the Assistant  Secretary of the
Company received before the proxy is voted or (iii) by such person(s) voting  in
person  at the 1997 Annual Meeting. Duly  executed proxies in the form enclosed,
unless properly revoked, will be voted at the 1997 Annual Meeting. The  expenses
incidental  to the preparation and mailing of this proxy material are being paid
by the Company.  The Company  will reimburse  banks, brokerage  firms and  other
custodians, nominees and fiduciaries for reasonable expenses incurred by them in
sending  proxy materials to  stockholders. No solicitation  currently is planned
beyond the  mailing of  this proxy  material to  stockholders and  to  brokerage
firms, nominees, custodians and fiduciaries, who may be requested to forward the
proxy materials to the beneficial owners of shares held of record by them.
 

<PAGE>
<PAGE>
                       VOTING SHARES AND QUORUM REQUIRED
 
     On the Record Date, the Company had outstanding 15,814,351 shares of Common
Stock, par value $.01 per share (the 'Common Stock'). Holders of Common Stock on
the  Record Date (the 'Common Stockholders') are  entitled to one vote per share
on all matters submitted to a vote of stockholders. The presence in person or by
proxy of the holders of a majority  of the issued and outstanding Common  Stock,
excluding  Common Stock held by the Company, is necessary to constitute a quorum
at the 1997 Annual Meeting.
 
     The affirmative  vote  of  a  plurality  of  the  shares  of  Common  Stock
represented  in person  or by proxy  at the  1997 Annual Meeting  is required to
elect the Directors. Business that might have been transacted at the 1997 Annual
Meeting as originally called  may be conducted at  any adjournment at which  the
requisite quorum is present.
 
     Pursuant  to  the laws  of the  State  of Delaware,  the inspectors  of the
election will not count shares  represented by proxies that reflect  abstentions
or  'broker  non-votes'  (i.e., shares  held  by  brokers or  nominees  that are
represented at the 1997 Annual Meeting, but with respect to which the broker  or
nominee  is not empowered to  vote on a particular  proposal) as votes cast with
respect to  the election  of Directors,  and therefor,  neither abstentions  nor
broker non-votes will affect the election of Nominees receiving the plurality of
votes.  With respect to  all other proposals  scheduled to come  before the 1997
Annual Meeting, abstentions with respect to a particular proposal will have  the
effect  of  a vote  against such  proposal. Broker  non-votes, however,  will be
treated as unvoted  for purposes of  determining approval of  such proposal  and
will not be counted as votes for or against such proposal.
 
                            MATTERS TO BE VOTED UPON
 
ELECTION OF DIRECTORS
 
     The  Company's by-laws (the 'By-laws') provide  that the Board of Directors
is divided into  three classes. Each  year the stockholders  elect Directors  to
succeed  those  Directors  whose  terms have  expired,  and  each  newly elected
Director will serve for a three-year term.
 
     The Nominees set forth below have been duly nominated to stand for election
as Directors of the  Company to serve for  a term of three  (3) years, or  until
their successors are elected and qualified.
 
     Each  of the Nominees has  indicated a willingness to  serve as a member of
the Board of Directors if elected. The Board of Directors recommends a vote  FOR
each  of the Nominees. If any of the Nominees should become unavailable prior to
the 1997 Annual Meeting, the  proxy will be voted  for a substituted nominee  or
nominees  designated by the  Board of Directors.  The information provided below
with respect to the Nominees is as of the Record Date.
 
     To be elected by the Common Stockholders:
 
<TABLE>
<CAPTION>
                                                           PRINCIPAL OCCUPATION AND
NAME                             AGE                           OTHER INFORMATION
- ------------------------------   ---   -----------------------------------------------------------------
<S>                              <C>   <C>
Michael Hyatt*................   51    Director of the Company since  November 1996. For more than  five
                                         years,  Mr. Hyatt has  been a Senior  Managing Director of Bear
                                         Stearns & Co., Inc.
 
James R. Ledley*/**...........   50    Director of  the  Company since  January  1992. Mr.  Ledley  also
                                         serves  as Assistant Secretary for  the Company. Since 1995, he
                                         has been a member of the law firm of Kleinberg, Kaplan, Wolff &
                                         Cohen, P.C. From 1980 to 1995 he  was a member of the law  firm
                                         of  Varet & Fink  P.C. (previously known  as Milgrim Thomajan &
                                         Lee P.C.).
</TABLE>
 
- ------------
 
 * Member of the Audit Committee.
 
** Member of the Compensation Committee.
 
                                       2
 

<PAGE>
<PAGE>
CONTINUING DIRECTORS
 
     JOHN W. LYLE  has served  as President and  Chief Executive  Officer and  a
Director  of the Company since its formation in January 1992. Mr. Lyle served as
President and Chief Executive Officer of OmniCorp Holdings, Inc., in 1991. Prior
to founding the Company, Mr. Lyle was one of the founders of Osteotech, Inc.,  a
public   orthopaedic  pharmaceutical  company  formed  in  1986.  He  served  as
Osteotech, Inc.'s Chairman and Chief Executive Officer from 1989 to 1991 and  as
President  from 1986 to 1989. From 1981 to 1986, Mr. Lyle served as President of
CIBA-GEIGY Corporation's Self-Medication, Inc. From 1975 to 1981, Mr. Lyle  held
various  positions at  Johnson &  Johnson. Mr.  Lyle holds  a B.S.  in Marketing
Management and  a M.B.A.  in General  Management, both  from the  University  of
Southern California.
 
     DONALD  G. DRAPKIN has been  a Director of the  Company since January 1994.
Mr. Drapkin has been Vice Chairman and Director of MacAndrews & Forbes  Holdings
Inc.,  and various of its affiliates for more  than five years. Mr. Drapkin is a
Director of  the  following corporations  which  file reports  pursuant  to  the
Securities  Exchange Act  of 1934, as  amended: Andrews  Group Incorporated, The
Coleman Company, Inc.,  Coleman Holdings, Inc.,  Coleman Worldwide  Corporation,
Consolidated   Cigar  Corporation,  Consolidated  Cigar  Holdings  Inc.,  Marvel
Entertainment Group, Inc.,  Marvel (Parent) Holdings  Inc., Marvel III  Holdings
Inc.,  Revlon,  Inc.,  Revlon Consumer  Products  Corporation,  Revlon Worldwide
Corporation, Toy Biz, Inc. and VIMRx Pharmaceuticals Inc. On December 27,  1996,
Marvel  Holdings,  Marvel  Parent, Marvel  III  and  Marvel and  several  of its
subsidiaries filed voluntary  petitions for reorganization  under Chapter 11  of
the  United States Bankruptcy Code. Mr. Drapkin  is a member of the Compensation
and Audit Committees of the Company's Board of Directors.
 
     ROGER H. KIMMEL has  been a Director  of the Company  since July 1996.  Mr.
Kimmel has been a partner of the law firm of Latham & Watkins for more than five
years. Mr. Kimmel is also a Director of Weider Nutrition International, Inc. and
TSR  Paging, Inc. Mr.  Kimmel is a  member of the  Compensation Committee of the
Company's Board of Directors.
 
     DIETER A. SULSER has been a Director  of the Company since May 1995.  Since
1991,  Mr. Sulser has served as Head of  Investment Banking for the ERB Group of
Companies, based in Zurich, Switzerland. Mr.  Sulser is also General Manager  of
Unifina Holding AG, an affiliate of the ERB Group of Companies.
 
     Messers.  Lyle and Drapkin  are in the  class of Directors  whose term will
expire in 1999; and  Messers. Kimmel and  Sulser are in  the class of  Directors
whose term will expire in 1998.
 
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
     The following table sets forth certain information concerning the ownership
of  Common Stock  by each  of the  Directors and  Nominees, the  Company's Chief
Executive Officer, each of the Company's other most highly compensated executive
officers, all Directors and executive officers as a group, and each  stockholder
who  is known by the Company to own beneficially more than 5% of the outstanding
Common Stock, as of the Record Date. Unless otherwise indicated, the address  of
each  beneficial owner  is c/o  the Company,  Collingwood Plaza,  4900 Route 33,
Neptune, New Jersey 07753.
 
     For purposes of the following  table, a person or  group is deemed to  have
'beneficial  ownership' of any shares which such person has the right to acquire
within 60  days  after  the  date  of this  Proxy  Statement.  For  purposes  of
calculating  the  percentage of  outstanding shares  held  by each  person named
above, any shares  which such person  has the  right to acquire  within 60  days
after  the date of the Proxy Statement are deemed to be outstanding, but not for
the purpose of calculating the percentage ownership of any other person.
 
                                       3
 

<PAGE>
<PAGE>
 
<TABLE>
<CAPTION>
                                                                  NUMBER OF SHARES     PERCENTAGE OF SHARES
NAME OF BENEFICIAL OWNER                                         BENEFICIALLY OWNED     BENEFICIALLY OWNED
- --------------------------------------------------------------   ------------------    --------------------
<S>                                                              <C>                   <C>
DIRECTORS AND EXECUTIVE OFFICERS
     John W. Lyle(a)..........................................        1,620,566                10.1%
     Frank S. Caruso(b).......................................          307,000                 1.9
     Gastone Bello............................................          153,550                  *
     Donald G. Drapkin(c).....................................           16,600                  *
     Michael Hyatt(d).........................................        1,346,894                 8.5
     Roger H. Kimmel(e).......................................          931,858                 5.9
     James R. Ledley(f).......................................          110,950                  *
     Dieter A. Sulser(g)......................................          153,550                  *
Directors and Executive Officers as a group(h)................        4,478,518                27.9
 
OTHER PRINCIPAL STOCKHOLDERS
     Unifina Holding AG and related investors(i)..............        1,734,700                11.0
     Karen Lyle(j)............................................        1,620,566                10.1
     Lawrence Canarelli(k)....................................          871,500                 5.5
     Gilbert Goldstein(l).....................................          862,750                 5.5
     Paul Shapiro(m)..........................................          809,250                 5.1
     Morris J. Kramer(n)......................................          809,246                 5.1
     Mellon Bank Corporation(o)...............................          800,000                 5.1
</TABLE>
 
- ------------
 
*   Represents less than 1%.
 
 (a) Includes (i) 74,700 shares of Common Stock owned directly by Mr. Lyle, (ii)
     1,354,966 shares of Common  Stock and options to  purchase 8,300 shares  of
     Common  Stock owned by Karen  Lyle, wife of Mr. Lyle,  as to which Mr. Lyle
     disclaims beneficial ownership and (iii) options to purchase 182,600 shares
     of Common Stock owned directly by Mr. Lyle, and excludes 664,000 shares  of
     Common  Stock held in  a trust for the  benefit of the  children of Mr. and
     Mrs. Lyle, as to which shares Mr. Lyle has neither the power of disposition
     nor the power to vote.
 
 (b) Includes (i) 1,000 shares  of Common Stock owned  directly by Mrs.  Caruso,
     wife  of Dr. Caruso, as to  which Dr. Caruso disclaims beneficial ownership
     and (ii) 7,200 shares of Common Stock held in a trust for which Dr.  Caruso
     serves  as trustee and as to which  shares Dr. Caruso holds either the sole
     or the shared power of disposition and the power to vote. Excludes a  total
     of  24,900 shares  held in  trust for  the benefit  of the  children of Dr.
     Caruso, as to which shares Dr. Caruso has neither the power of  disposition
     nor the power to vote.
 
 (c) Excludes  a total of 809,246 shares of  Common Stock held in six trusts for
     the benefit of the children of Mr. Drapkin, as to which shares Mr.  Drapkin
     has neither the power of disposition nor the power to vote.
 
 (d) Includes  (i) 829,751 shares  of Common Stock owned  directly by Mr. Hyatt,
     (ii) 513,810  shares held  in five  trusts for  which Mr.  Hyatt serves  as
     trustee  and as  to which  shares Mr.  Hyatt holds  either the  sole or the
     shared power  of disposition  or the  power to  vote and  (iii) options  to
     purchase  3,333  shares of  Common Stock,  and  excludes 221,332  shares of
     Common Stock held in a trust for the benefit of the children of Mr.  Hyatt,
     as  to which shares Mr. Hyatt has  neither the power of disposition nor the
     power to vote.
 
 (e) Includes (i) 507,193 shares of Common Stock owned by an estate of which Mr.
     Kimmel is the executor,  (ii) 371,332 shares held  in trusts for which  Mr.
     Kimmel serves as trustee and as to which shares Mr. Kimmel holds either the
     sole or the shared power of disposition and power to vote and (iii) options
     to  purchase 3,333  shares of Common  Stock and excludes  343,060 shares of
     Common Stock held  in two trusts  for the  benefit of the  children of  Mr.
     Kimmel,  as to which shares Mr. Kimmel has neither the power of disposition
     nor the power to vote.
 
 (f) Includes a total of  1,500 shares of  Common Stock held in  a trust, as  to
     which  shares Mr. Ledley holds the shared power of disposition and power to
     vote.
 
                                              (footnotes continued on next page)
 
                                       4
 

<PAGE>
<PAGE>
(footnotes continued from previous page)
 
 (g) Includes 141,100 shares  of Common  Stock and 12,450  warrants to  purchase
     shares  of Common Stock owned directly by  Gaby Sulser, wife of Mr. Sulser,
     as  to  which  Mr.  Sulser  disclaims  beneficial  ownership  and  excludes
     1,734,700  shares beneficially  owned by  Unifina Holding  AG, as  to which
     shares Mr. Sulser disclaims beneficial ownership. Mr. Sulser is the General
     Manager of Unifina Holding AG.
 
 (h) Includes options and warrants to purchase 210,016 shares of Common Stock.
 
 (i) Consists of  1,577,000  shares of  Common  Stock and  157,700  warrants  to
     purchase  shares of  Common Stock  held by  EBC Zurich  AG. The  address of
     Unifina Holding AG is Zurcherstrasse  62; CH 8406, Winterthur,  Switzerland
     and  the address of EBC  Zurich AG is Bellariastrasse  23; CH 8027, Zurich,
     Switzerland. Excludes (i) 166,000  shares of Common  Stock and warrants  to
     purchase 16,600 shares of Common Stock held by Mr. Rolf P. Erb, Chairman of
     EBC Zurich AG and a member of the board of directors of Unifina Holding AG,
     as  to which shares each  of Unifina Holding AG  and EBC Zurich AG disclaim
     beneficial ownership and (ii) 141,100  shares of Common Stock and  warrants
     to purchase 12,450 shares of Common Stock beneficially owned by Mr. Sulser,
     General  Manager of Unifina Holding AG,  as to which shares Unifina Holding
     AG disclaims beneficial ownership.
 
 (j) Includes (i) 1,354,966 shares of Common Stock and options to purchase 8,300
     shares of Common Stock, owned directly by Mrs. Lyle and (ii) 74,700  shares
     of  Common Stock  and options  to purchase  182,600 shares  of Common Stock
     owned directly by John Lyle,  husband of Mrs. Lyle,  as to which Mrs.  Lyle
     disclaims beneficial ownership, and excludes 664,000 shares of Common Stock
     held in a trust for the benefit of the children of Mr. and Mrs. Lyle, as to
     which  shares Mrs. Lyle has neither the  power of disposition nor the power
     to vote.
 
 (k) Includes 664,000 shares of Common Stock deemed to be beneficially owned  by
     each  of Mrs. Albert and Mr. Canarelli  in their shared capacity as trustee
     for a trust as to which shares each of Mrs. Albert and Mr. Canarelli  share
     the power of disposition and the power to vote.
 
 (l) Includes  809,250 shares of Common Stock deemed to be beneficially owned by
     Mr. Goldstein in his capacity as trustee for a trust as to which shares Mr.
     Goldstein has the shared power of disposition and power to vote.
 
(m) Includes 809,250 shares of Common Stock  deemed to be beneficially owned  by
    Mr.  Shapiro in his capacity  as trustee for a trust  as to which shares Mr.
    Shapiro has the shared power of disposition and power to vote.
 
 (n) Includes 809,246 shares of Common Stock deemed to be beneficially owned  by
     Mr.  Kramer in his capacity  as trustee for a trust  as to which shares Mr.
     Kramer holds the power of disposition and the power to vote.
 
 (o) The shares of  Common Stock  for Mellon Bank  Corporation are  held by  its
     subsidiary, the Dreyfus Corporation. The address of the Dreyfus Corporation
     is One Mellon Bank Center, Pittsburgh, Pennsylvania 15258.
 
                                       5
 

<PAGE>
<PAGE>
                             EXECUTIVE COMPENSATION
 
SUMMARY EXECUTIVE COMPENSATION TABLE
 
     The following table sets forth the annual, long-term and other compensation
of  the  Company's Chief  Executive Officer  and  other most  highly compensated
executives whose annual base salaries equal or exceed $100,000:
 
                           SUMMARY COMPENSATION TABLE


<TABLE>
<CAPTION>
                                                                                           LONG-TERM COMPENSATION
                                                                              ------------------------------------------------
                                                                                     AWARDS                    PAYOUTS
                                                                              ---------------------    -----------------------
                                      ANNUAL COMPENSATION        OTHER        RESTRICTED    OPTIONS    
NAME AND PRINCIPAL                    --------------------       ANNUAL         STOCK        (# OF      LTIP       ALL OTHER
  POSITION                  YEARLY     SALARY      BONUS      COMPENSATION      AWARDS      SHARES)    PAYOUTS    COMPENSATION
- -------------------------   ------    --------    --------    ------------    ----------    -------    -------    ------------
<S>                         <C>       <C>         <C>         <C>             <C>           <C>        <C>        <C>
John W. Lyle
  President & Chief
  Executive Officer......    1996     $254,000    $127,000        -              -          132,800      -            -
                             1995     $235,000    $ 75,000        -              -             -         -            -
Frank S. Caruso,
  Executive Vice
  President
  for Research &
  Development............    1996     $173,500    $ 57,750        -              -           33,200      -            -
                             1995     $165,000    $ 25,000        -              -             -         -            -
</TABLE>


 
     The following table sets forth for each of the named executive officers the
value realized from stock options exercised during 1996 and the number and value
of exercisable and unexercisable stock options held at December 31, 1996:
 
                     OPTION/SAR GRANTS IN LAST FISCAL YEAR
 
<TABLE>
<CAPTION>
                                              INDIVIDUAL GRANT                                 POTENTIAL REALIZABLE
                          ---------------------------------------------------------              VALUE AT ASSUMED
                           NUMBER OF        % OF TOTAL                                        ANNUAL RATES OF STOCK
                           SECURITIES      OPTIONS/SARS     EXERCISE                          PRICE APPRECIATION FOR
                           UNDERLYING       GRANTED TO      OR BASE                                OPTION TERM
                          OPTIONS/SARS     EMPLOYEES IN      PRICE       EXPIRATION     ----------------------------------
         NAME               GRANTED        FISCAL YEAR       ($/SH)         DATE         0% ($)       5% ($)      10% ($)
- ----------------------    ------------     ------------     --------     ----------     --------     --------     --------
<S>                       <C>              <C>              <C>          <C>            <C>          <C>          <C>
John W. Lyle..........       132,800            57           $ 0.13        4/01/01      $606,040     $778,343     $986,782
Frank S. Caruso.......        33,200            14           $ 0.12        4/01/06      $151,910     $249,962     $400,392
</TABLE>
 
      AGGREGATED OPTION EXERCISES IN LAST YEAR AND YEAR END OPTION VALUES
 
<TABLE>
<CAPTION>
                                                                  NUMBER OF SHARES
                                                                   OF UNDERLYING                VALUE OF UNEXERCISED
                                   SHARES                       UNEXERCISED OPTIONS             IN-THE-MONEY OPTIONS
                                 ACQUIRED ON     VALUE      ----------------------------    ----------------------------
                                  EXERCISE      REALIZED    EXERCISABLE    UNEXERCISABLE    EXERCISABLE    UNEXERCISABLE
                                 -----------    --------    -----------    -------------    -----------    -------------
<S>                              <C>            <C>         <C>            <C>              <C>            <C>
John W. Lyle..................       -             -          182,200         174,300       $ 2,030,050     $ 1,937,775
Frank S. Caruso...............      49,800      $233,866       58,100          74,700       $   646,625     $   831,375
</TABLE>
 
EMPLOYMENT AGREEMENTS
 
     Mr. Lyle's employment agreement  with the Company  expires on December  31,
1997  and  is  automatically  renewable  for  successive  one-year  terms unless
terminated by either Mr.  Lyle or the Company.  Mr. Lyle's employment  agreement
provides  that he will be employed as  the President and Chief Executive Officer
of the Company and that the Company will use its best efforts to cause him to be
elected to the Board  of Directors for  the term of the  agreement. Mr. Lyle  is
entitled  to a minimum increase  of 8% per year or  such greater increase as the
Board of Directors, in its sole  discretion, deems appropriate to the  preceding
year's  base  salary  and  for  bonuses  for  individual  accomplishment  of key
 
                                       6
 

<PAGE>
<PAGE>
milestone events in such amounts and on such terms as the Board of Directors may
determine. Mr. Lyle's employment agreement  acknowledges that during the  period
of  his employment, he  will also serve  as the Chief  Executive Officer of U.S.
Medical Development,  Inc. ('USMDI'),  a Delaware  corporation, incorporated  in
January 1994 by the founders of the Company.
 
     Dr.  Caruso's employment agreement with the Company expires on December 31,
1997 and  is  automatically  renewable  for  successive  one-year  terms  unless
terminated  by either Dr. Caruso or the Company.  Dr. Caruso is entitled to a 5%
increase per year or  such greater increase  as the Board  of Directors, in  its
sole  discretion, deems appropriate  to the preceding year's  base salary and is
entitled to receive  continuing payments equal  to twelve months  salary in  the
event  of his  termination by  the Company  without cause.  Dr. Caruso  may also
receive bonuses for individual  accomplishment of key  milestone events in  such
amounts and on such terms as the Board of Directors may determine.
 
     Dr.  Bello's employment agreement with the  Company expires on December 31,
1997 and  is  automatically  renewable  for  successive  one-year  terms  unless
terminated  by either Dr.  Bello or the Company.  Dr. Bello is  entitled to a 5%
increase per year or  such greater increase  as the Board  of Directors, in  its
sole  discretion, deems appropriate  to the preceding year's  base salary and is
entitled to receive continuing payments equal to six months salary in the  event
of  his termination  by the  Company without cause.  Dr. Bello  may also receive
bonuses for individual accomplishment  of key milestone  events in such  amounts
and on such terms as the Board of Directors may determine.
 
COMPENSATION OF OUTSIDE DIRECTORS
 
     Non-employee   members  of  the  Board   of  Directors  will  receive  cash
compensation of $1,500 per meeting attended as consideration for their  services
as  Directors of the  Company and are reimbursed  for reasonable travel expenses
incurred in  connection with  their attendance  at such  meetings.  Non-employee
Directors upon appointment or election to the Board of Directors will receive an
option grant under the Company's 1996 Non-Employee Director Stock Option Plan to
purchase  10,000 shares of Common Stock, at the fair market value on the date of
grant, vesting over  a three-year period  upon each anniversary  of the date  of
grant.  In addition, on the date of the  first meeting of the Board of Directors
in each calendar  year, each non-employee  Director will be  granted options  to
purchase  5,000 shares of Common Stock, at the  fair market value on the date of
grant, which shall vest  on the first  anniversary from the  date of grant.  See
'Stock Option Plans.'
 
         REPORT OF THE COMPENSATION COMMITTEE ON EXECUTIVE COMPENSATION
 
     Compensation  Policy  and Company  Performance. The  executive compensation
program has been designed with the  goal of motivating, rewarding and  retaining
executives  with the level of talent and ability required to guide the Company's
growth, efficiently  manage  its  resources,  achieve  its  long-range  business
objectives  and successfully maintain  its position as a  leader in developing a
new generation of proprietary pain management products. The compensation program
provides  the  means  of  achieving  these  goals  by  creating  incentives   to
accomplishing    short-term    and    long-term    objectives,    by   rewarding
exceptional performance  that  contributes  to the  business  and  by  utilizing
competitive base salaries that recognize a policy of career continuity.
 
     The  Company's financial well being is highly dependent upon the success of
its long-term growth strategy.  The nature of  this strategy requires  long-term
and  significant  investments,  which  may take  years  to  generate  returns to
stockholders. Therefore, executive  compensation decisions  are oriented  toward
long-term corporate performance and may not fluctuate as greatly as year-to-year
corporate financial results.
 
     The  fundamental  principle of  the compensation  program is  to compensate
executives  for  their   performance  and  for   the  level  of   responsibility
corresponding  to their positions. Assessments  of both individual and corporate
performance influence compensation levels. The Compensation Committee recognizes
the importance  of  fostering  a performance-based  environment  that  motivates
individual achievement. Thus, executives are regularly given recognition for the
prior  year's results, which are not necessarily financial results, and provided
with incentives to augment their successes in the future.
 
                                       7
 

<PAGE>
<PAGE>
     The Compensation Committee makes compensation determinations for all of the
Company's senior  management, including  the individuals  whose compensation  is
detailed  in this  proxy. Compensation  decisions for  all executives, including
John W. Lyle, the Company's Chief  Executive Officer, are based on the  criteria
disclosed above.
 
     There  are three  primary elements  of the  Company's compensation program:
base salary, bonus payments and awards under  the 1994 Option Plan and the  1996
Option Plan (together, the 'Stock Plans').
 
     Base  Salaries. A competitive  base salary is  necessary to the development
and retention  of  capable  management  and is  consistent  with  the  Company's
long-term goals.
 
     Current  base  salary levels  for executives  result from  a review  of the
Company's  business  performance  and  general  economic  factors.  Within  this
framework,  executive  salaries  are  governed  in  part  by  various employment
agreements  and  are  determined  based  on  individual  performance,  level  of
responsibility within the Company and experience.
 
     Bonus  Payments. Targeted cash bonus payments  are awarded to executives in
recognition  of  contributions  to  the  business  during  the  prior  year.  An
executive's  contributions to the business are measured,  in part, by his or her
success in meeting certain goals established by such executive and the Company's
Chief Executive Officer.  The aggregate  amount of  the bonuses  awarded in  any
calendar  year  is  determined  by  reference  to  the  terms  of  the executive
employment  agreements,  the  Company's  competitive  position,  assessment   of
progress  in attaining long-term goals  and business performance considerations.
Because  of  the  Company's  developmental  stage,  these  business  performance
considerations do not include traditional measurements such as annual cash flow,
earnings  per share and return on investments,  but rather, how well the Company
has achieved its  targeted developmental  goals. None of  these measurements  is
given a specific weight. No formula was used in determining the aggregate amount
of the bonuses awarded to executives in 1996.
 
     The  specific cash bonus  an executive receives  is dependent on individual
performance and level of responsibility. Assessment of an individual's  relative
performance is made annually based on a number of factors, including initiative,
business judgment, knowledge of the industry and management skills.
 
     Awards  under the Stock Plans. Awards under the Stock Plans are designed to
promote an identity of interests between management and stockholders. Under  the
Stock  Plans, the Company's executives are eligible to receive grants of options
to purchase Common Stock at or above fair market value on the date of the grant.
Typically, grants of stock options are subject to a significant vesting  period.
This  approach  is  designed to  increase  long-term stockholder  value,  as the
maximum benefit of this  element of executive compensation  is only realized  if
stock price appreciation occurs over a number of years.
 
     Awards of stock options were granted to certain executives in 1996 based on
individual   performance  (determined  as  described  above  under  '  --  Bonus
Payments') and level of responsibility.  Award levels are generally intended  to
be  sufficient in size to provide a  strong incentive for executives to work for
long-term business  interests and  increase such  executives' ownership  in  the
business.  See  'Executive  Compensation  --  Summary  Compensation  Table'  and
'Executive Compensation -- Option/SAR Grants in Last Fiscal Year.'
 
     Policy on the Deductibility of Compensation. Section 162(m) of the Internal
Revenue Code of 1986 as amended (the 'Code'), limits a public company's  federal
income tax deduction for compensation paid in excess of $1,000,000 to any of its
five    most   highly   compensated   executive   officers.   However,   certain
performance-based compensation, including awards  of stock options, is  excluded
from the $1,000,000 limit if specific requirements are met.
 
     While the tax impact of any compensation arrangement is one factor which is
considered  by the Compensation Committee, such  impact is evaluated in light of
the  compensation  policies  discussed   above.  The  Compensation   Committee's
compensation  determinations  have  generally  been  designed  to  maximize  the
Company's federal income tax deduction for possible application in future years.
However, from  time to  time compensation  may  be awarded  which is  not  fully
deductible  if it is determined  that such award is  consistent with the overall
design of the compensation program and in the best interests of the Company  and
its stockholders.
 
                                       8
 

<PAGE>
<PAGE>
     Chief  Executive Officer Compensation. The Chief Executive Officer's salary
is determined based  upon Mr.  Lyle's employment agreement  and the  competitive
salary  framework described  under ' --  Base Salaries,'  above, recognizing the
Company's significant growth and the increasing complexity of its business.  The
minimum  base salary  and annual  increases set  forth in  Mr. Lyle's employment
agreement were determined based on  the Board of Directors' judgment  concerning
his individual contributions to the business, level of responsibility and career
experience. Although none of these factors were given a specific weight, primary
consideration  was given to Mr. Lyle's individual contributions to the business.
No particular formulas or measures were used.
 
     The amount of Mr. Lyle's 1996  bonus payment was established in  accordance
with  Mr. Lyle's employment  agreement, based upon  the Company's achievement of
various milestones in  product development  and Company  funding, including  the
completion  of a pivotal clinical study of MorphiDexTM, the execution of license
and collaborative development  agreements and  the completion  of the  Company's
initial  public  offering (the  'IPO').  The bonus  amount  fixed in  Mr. Lyle's
employment agreement  reflects Mr.  Lyle's level  of responsibility  within  the
organization and overall contributions as Chief Executive Officer.
 
     In January 1997, the  Company granted Mr.  Lyle a total  of 40,000  options
vesting over a 4 year period under the 1996 Option Plan; 25,000 of  such options
are  Incentive  Stock  Options (as defined) with an exercise price of $16.50 per
share,  with  the remaining 15,000 having an exercise price of $15.00 per share.
Mr. Lyle's award under the 1996 Option Plan reflects his level of responsibility
within  the  organization and his leadership which has significantly contributed
to  the  Company's corporate performance. Mr. Lyle's Stock Plans award  reflects
the  Compensation Committee's judgment of his overall  contributions  as   Chief
Executive  Officer.  In making  this  determination, the  Compensation Committee
considered the complex, diverse,  and rapidly changing  nature of the  Company's
business.   Narrow  quantitative  measures   or  formulas  are   not  viewed  as
sufficiently comprehensive for this purpose.
 
     Conclusion. The Company has had, and continues to have, an appropriate  and
competitive  compensation  program. The  balance  of a  competitive  base salary
position, bonus payments and significant  emphasis on long-term incentives is  a
foundation  designed to build  stability and to  support the Company's continued
growth. This report is submitted by the members of the Compensation Committee:
 
                             COMPENSATION COMMITTEE
                               Donald G. Drapkin
                                Roger H. Kimmel
                                James R. Ledley
 
THE PRECEDING 'REPORT OF THE  COMPENSATION COMMITTEE ON EXECUTIVE  COMPENSATION'
AND  THE 'STOCK PERFORMANCE CHART' THAT  APPEARS IMMEDIATELY HEREAFTER SHALL NOT
BE DEEMED TO  BE SOLICITING  MATERIAL OR  TO BE  FILED WITH  THE SECURITIES  AND
EXCHANGE  COMMISSION  UNDER  THE SECURITIES  ACT  OF  1933, AS  AMENDED,  OR THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED, OR INCORPORATED BY REFERENCE IN ANY
DOCUMENTS SO FILED.
 
                            STOCK PERFORMANCE CHART
 
     As part of the executive  compensation information presented in this  Proxy
Statement,  the Securities and Exchange Commission (the 'Commission') requires a
comparison of stock  performance for  the Company  with stock  performance of  a
broad equity market index and an appropriate industry index. The following chart
compares  the cumulative total stockholder return on the Common Stock during the
period from September 25,  1996 to December 31,  1996 with the cumulative  total
return  on the Nasdaq Composite  Index  and   a  peer  group  index  of   Nasdaq
pharmaceutical companies. The
 
                                       9
 

<PAGE>
<PAGE>
comparison assumes $100 was invested on  September 25, 1996 (the effective  date
of the IPO) in the Common Stock and in each of the foregoing indices and assumes
reinvestment  of dividends, if any. The stock performance shown on the following
chart is not necessarily indicative of future performance.

                              [PERFORMANCE GRAPH]

                                      9/25/96     12/31/96
Nasdaq Composite Index                 100.00      105.10
Peer Group Index                       100.00       98.79
Algos Pharmaceutical Corporation       100.00       80.36


 
                               STOCK OPTION PLANS
 
1994 STOCK OPTION PLAN
 
     Effective January 1994,  the Company established  the Algos  Pharmaceutical
Corporation  1994 Stock  Option Plan  (the '1994  Option Plan')  under which key
employees may be granted  options to purchase shares  of Common Stock. The  1994
Option  Plan  is intended  to  assist the  Company  in attracting  and retaining
employees of  outstanding ability  and to  promote the  identification of  their
interests  with those  stockholders of the  Company. The Company  has reserved a
total of 830,000  shares of  Common Stock for  issuances under  the 1994  Option
Plan.
 
     Unless  sooner terminated by  the Board of Directors,  the 1994 Option Plan
will expire ten years after its inception. The 1994 Option Plan is  administered
by the Board of Directors, which has the authority to select eligible employees,
grant options under the plan and determine the terms, price, and form of payment
for  each grant. Awards under the 1994  Option Plan will generally be granted at
an exercise price equal to the then fair market value per share of Common Stock.
Options granted under the 1994 Option Plan are generally not transferable except
upon an employee's death, at  which time all options  that have been granted  to
such employee are deemed to be exercisable, subject to certain conditions.
 
1996 STOCK OPTION PLAN
 
     In  April 1996,  the Company  adopted the  Algos Pharmaceutical  1996 Stock
Option Plan (the '1996 Option Plan'). The 1996 Option Plan is intended to assist
the  Company  in  attracting  and   retaining  key  employees  and   independent
consultants  of outstanding ability  and to promote  the identification of their
interests with those  interests of  the stockholders  of the  Company. The  1996
Option Plan permits the grant of non-qualified stock options and incentive stock
options  to  purchase shares  of Common  Stock  covering 415,000  authorized but
unissued or reacquired shares of Common Stock, subject to adjustment to  reflect
events  such  as stock  dividends, stock  splits, recapitalizations,  mergers or
reorganizations of or by the Company.
 
     Unless sooner terminated by  the Board of Directors,  the 1996 Option  Plan
will  expire on January 31, 2006. Such  termination will not affect the validity
of any option outstanding under the 1996 Option Plan on the date of termination.
 
                                       10
 

<PAGE>
<PAGE>
     The Compensation  Committee  administers the  1996  Option Plan  (which  is
intended to satisfy the requirements of Rule 16b-3 under the Securities Exchange
Act  of 1934, as amended  (the 'Exchange Act'), and  Section 162(m) of the Code.
Subject to the terms  and conditions of the  1996 Option Plan, the  Compensation
Committee  has the authority  to select the  person to whom  grants are made, to
designate the  number of  shares of  Common  Stock covered  by such  grants,  to
determine   the  exercise  price   of  options,  to   establish  the  period  of
exercisability of options, and to make all other determinations and to take  all
other  actions necessary or advisable for  the administration of the 1996 Option
Plan. Subject to the requirements  of the 1996 Option  Plan, the dates on  which
options  become  exercisable and  on which  they  expire shall  be set  forth in
individual option  agreements.  Such  agreements  will  generally  provide  that
options  expire  within one  year following  the  termination of  the optionee's
status as an employee  or consultant of the  Company (or a subsidiary)  although
the  Compensation Committee may provide that  options continue to be exercisable
following a termination without 'Cause' (as defined in the 1996 Option Plan)  or
otherwise.  The Company also may, in its  discretion, provide by the terms of an
option that such  option will  expire at  specified times  following, or  become
exercisable  in  full upon  the occurrence  of certain  specified 'extraordinary
corporate events'  including  a  merger, consolidation  or  dissolution  of  the
Company,  or a sale  of substantially all  of the Company's  assets, but in such
event the Compensation Committee may also  give optionees the right to  exercise
their  outstanding options in full during some  period prior to such event, even
though  the   rights  have   not  yet   otherwise  become   fully   exercisable.
Notwithstanding the foregoing, upon a 'Corporate Transaction' (as defined in the
1996  Option Plan), all outstanding options shall become immediately exercisable
if not assumed by the surviving corporation.
 
     Incentive stock options ('Incentive Stock Options') granted under the  1996
Option  Plan will be designed to comply with the provisions of the Code and will
be subject to  certain restrictions  contained in the  Code. These  restrictions
require  that Incentive Stock Options  (i) have an exercise  price not less than
the fair market value of a share of Common Stock on the date of grant, (ii)  may
only  be granted to  employees, (iii) must  expire within a  specified period of
time following  the  optionee's  termination  of employment  and  (iv)  must  be
exercised within ten years after the date of the grant.
 
     In  the case of an Incentive Stock Option granted to an individual who owns
(or is deemed to  own) at least 10%  of the total combined  voting power of  all
classes of stock of the Company, the exercise price must be at least 110% of the
fair  market value  of a share  of Common  Stock on the  date of  grant and must
expire five years after grant. Furthermore,  the 1996 Option Plan provides  that
the  aggregate fair market value (determined at  the time the option is granted)
of shares with respect to which  Incentive Stock Options may be exercisable  for
the  first time during any calendar year,  may not exceed $100,000 per employee.
Options for shares, the fair market value of which exceeds the $100,000 per year
limit, will be treated as non-qualified stock options.
 
     Options  intended  to  satisfy  the  requirements  for   'performance-based
compensation'  under Section 162(m) of the Code must also have an exercise price
of not less  than fair market  value on the  date granted and  must comply  with
other limitations and restrictions.
 
     The  1996 Option Plan may be amended by the Compensation Committee, subject
to stockholder approval if such approval  is then required by applicable law  or
in  order for the 1996 Option Plan and options granted thereunder to satisfy the
requirements of Rule 16b-3 under the Exchange Act or Section 162(m) of the Code.
 
     The 1996 Option Plan permits the payment of the option exercise price to be
made in cash (which may include an  assignment of the right to receive the  cash
proceeds  from the  sale of  Common Stock  subject to  the option  pursuant to a
'cashless exercise' procedure) or by delivery  of shares of Common Stock  valued
at  their fair  market value  on the date  of exercise  or by  delivery of other
property, or by  a recourse  promissory note  payable to  the Company,  or by  a
combination  of the foregoing.  As a condition of  exercise, optionees must also
provide for  the  payment of  withholding  tax  obligations of  the  Company  in
connection with such exercise.
 
     Options  granted  under  the 1996  Option  Plan shall  not  be transferable
otherwise than by will, by the laws of descent and distribution or pursuant to a
qualified domestic  relations  order  (as  defined in  the  Code),  and  may  be
exercised  during the optionee's lifetime only by  the optionee or, in the event
of the optionee's legal disability, by the optionee's legal representative.
 
                                       11
 

<PAGE>
<PAGE>
1996 NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN
 
     In April 1996,  the Company  adopted the 1996  Non-Employee Director  Stock
Option  Plan (the  'Director Plan') covering  83,000 authorized  but unissued or
reacquired shares of Common Stock, subject to adjustment to reflect events  such
as  stock dividends, stock splits, recapitalizations, mergers or reorganizations
of or by the  Company. The Director  Plan is intended to  assist the Company  in
attracting and retaining qualified non-employee directors ('Outside Directors').
 
     The  Director Plan  is administered by  the Board of  Directors and options
granted under the Director Plan are intended to satisfy the requirements of Rule
16b-3 under the Exchange Act. The Director Plan provides for automatic grants of
non-qualified stock options to  purchase 10,000 shares of  Common Stock to  each
Outside  Director  at  the time  of  appointment  or election  to  the  Board of
Directors.
 
     The exercise price of the options shall be the fair market value of a share
of Common Stock on the  date of grant. Each  option shall become exercisable  in
cumulative  annual installments of  one-third on each of  the first three annual
meetings of the Company's  stockholders following the date  of grant so long  as
the  Outside Director continues to serve as  a Director of the Company; provided
however, to  the extent  permitted by  Rule 16b-3,  the Board  of Directors  may
accelerate  the  exercisability  of  options  upon  the  occurrence  of  certain
specified extraordinary corporate transactions  or events and provided  further,
that  in any  event, upon  the occurrence  of a  'Corporate Transaction'  of the
Company (as defined in the Director  Plan) all outstanding options shall  become
immediately  exercisable. No portion of an option shall be exercisable after the
tenth anniversary of the date of grant and no portion of an option shall  became
exercisable  following  termination  of  the Outside  Director's  services  as a
Director of the Company.
 
     Unless sooner terminated by the Board of Directors, the Director Plan  will
expire ten years after the date of adoption. Such expiration will not affect the
validity of any option outstanding on the date of termination.
 
     Each  Outside Director serving  as a Director  of the Company  at the first
regular meeting of the Board of Directors each calendar year shall be granted an
option to purchase 5,000 shares of Common Stock, which options shall vest on the
anniversary of the date of grant.
 
CERTAIN FEDERAL INCOME TAX CONSEQUENCES WITH  RESPECT TO OPTIONS UNDER THE  1994
OPTION PLAN, 1996 OPTION PLAN AND THE DIRECTOR PLAN
 
     An  optionee generally will not recognize taxable  income on the grant of a
non-qualified stock option under the 1994  Option Plan, the 1996 Option Plan  or
the  Director Plan, but will  recognize ordinary income on  the exercise of such
option. The amount of income recognized  on the exercise of an option  generally
will  be equal to the excess, if any, of  the fair market value of the shares at
the time of  exercise over  the aggregate exercise  price paid  for the  shares,
regardless  of whether the exercise price is paid  in cash or in shares or other
property. Where ordinary income is recognized by an optionee in connection  with
the exercise of an option, the Company generally will be entitled to a deduction
equal to the amount of ordinary income so recognized.
 
     An  optionee generally  will not recognize  taxable income  upon either the
grant or exercise  of an Incentive  Stock Option granted  under the 1996  Option
Plan. Generally, upon the sale or other taxable disposition of the shares of the
Common  Stock acquired upon exercise of  an Incentive Stock Option, the optionee
will recognize long-term capital gain in an amount equal to the excess, if  any,
of  the  amount realized  in such  disposition over  the option  exercise price,
provided that no disposition of the shares has taken place within either (a) one
year from the date of exercise  or (b) two years from  the date of grant of  the
Incentive  Stock Option. If the shares of the Common Stock are sold or otherwise
disposed of before the end of the one-year and two-year periods specified above,
the difference between the  Incentive Stock Option exercise  price and the  fair
market  value of the shares on the date of the Incentive Stock Option's exercise
generally will be taxable as ordinary income; the balance of the amount realized
from such disposition, if any, will be  taxed as capital gain. If the shares  of
Common  Stock are disposed of before the expiration of the one-year and two-year
periods and the amount realized is less than the fair market value of the shares
at the date of exercise, the optionee's ordinary
 
                                       12
 

<PAGE>
<PAGE>
income generally is limited  to the excess,  if any, of  the amount realized  in
such  disposition over  the option  exercise price  paid. The  Company (or other
employer corporation) generally will be entitled to a tax deduction with respect
to an Incentive Stock Option only to the extent the optionee has ordinary income
upon sale or other disposition of the shares of Common Stock.
 
     The rules governing the tax treatment of options and an optionee's  receipt
of  shares in connection with such grants are quite technical, so that the above
description of tax consequences  is necessarily general in  nature and does  not
purport  to be complete. Moreover, statutory  provisions are, of course, subject
to change,  as are  their interpretations,  and their  application may  vary  in
individual  circumstances. Finally, the tax  consequences under applicable state
law may not be the same as under the federal income tax laws.
 
                              CORPORATE GOVERNANCE
 
MEETINGS AND COMMITTEES OF THE BOARD OF DIRECTORS
 
     The business of the Company is managed under the direction of the Board  of
Directors.  The Board of  Directors meets on a  regularly scheduled basis during
the year to review significant developments affecting the Company and to act  on
matters  requiring approval  by the  Board of  Directors. It  also holds special
meetings when an  important matter  requires action  by the  Board of  Directors
between  scheduled meetings.  Since the consummation  of the  Company's IPO, the
Board of  Directors  has  met three  times.  The  Board of  Directors  acted  by
unanimous written consent eleven times during 1996.
 
     The  Company has  established a  standing Audit  Committee of  the Board of
Directors (the 'Audit Committee'). The  Audit Committee meets periodically  with
management  and the Company's  independent auditors to  review the activities of
each and  to discuss  audit matters,  financial reporting  and the  adequacy  of
internal  corporate  controls. Donald  G. Drapkin,  Michael  Hyatt and  James R.
Ledley currently serve on  the Audit Committee. The  Audit Committee was  formed
immediately  prior to the  consummation of the  IPO in October  1996 and did not
meet during  1996. Mr.  Hyatt was  appointed  to the  Audit Committee  upon  his
election to the Board of Directors in November 1996.
 
     The  Company does not  have a standing  nominating committee. The functions
customarily attributable to a nominating committee are performed by the Board of
Directors as  a  whole.  The  Company  will  consider  nominees  recommended  by
stockholders,  although  it  has  not  actively  solicited  recommendations from
stockholders for nominees nor has it established any procedures for this purpose
for the 1997  Annual Meeting  other than  as set forth  in the  By-laws. In  the
future,  stockholders  wishing  to recommend  a  person for  consideration  as a
nominee for election to the Company's Board of Directors can do so in accordance
with the  By-laws  by giving  timely  written notice  to  the Secretary  of  the
Company,  that  provides  each  such  nominee's  name,  appropriate biographical
information and  any  other  information  that would  be  required  in  a  proxy
statement  or other filings required to  be made in connection with solicitation
of proxies for the election of Directors and the class and the number of  shares
of  capital stock of the Company that are owned beneficially or of record by the
stockholder making  the  nomination. Such  notice  should be  accompanied  by  a
written  statement from each nominee consenting to  be named as a nominee and to
serve as a Director if elected. To be timely, such notice must be delivered  to,
or if mailed, received at, the Company's executive offices not less than 60 days
nor  more than  90 days  prior to the  anniversary of  the immediately preceding
annual meeting of stockholders; provided however, that if the annual meeting  is
called  for a date that  is not within 30 days  before or after such anniversary
date, notice by the stockholder  in order to be timely  must be so received  not
later  than the close of business on the  tenth day following the earlier of the
day on which such notice of the date of the annual meeting was mailed or  public
disclosure of the date of the annual meeting was made.
 
     The  Company has established a standing Compensation Committee of the Board
of Directors (the 'Compensation Committee').  Since its formation in  connection
with  the  consummation  of the  IPO,  the  Compensation Committee  has  had the
authority to  approve any  offers  to potential  employees  of the  Company  for
positions  of Senior  Vice President  or above,  or positions  with compensation
packages consisting of (a)  annual salaries of $150,000  or more, (b) grants  of
options  to purchase 10,000 shares of Common Stock when the grants are below the
fair   market   value    on   the   date    of   grant   and    vest   over    a
 
                                       13
 

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<PAGE>
period shorter than four years or (c) grants to purchase more than 10,000 shares
of  Common  Stock regardless  of  strike price  of  the options  or  the vesting
schedule. The  Compensation  Committee  was  formed  immediately  prior  to  the
consummation  of  the IPO  on October  1,  1996 and  acted by  unanimous written
consent one time in 1996  and held no meetings  during 1996. Donald G.  Drapkin,
Roger  H. Kimmel  and James  R. Ledley have  been appointed  to the Compensation
Committee.
 
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
     Mr. Roger H. Kimmel,  a Director of  the Company is a  partner at Latham  &
Watkins which performs legal services for the Company from time to time.
 
     Mr. James R. Ledley, a Director of the Company, is a member of the law firm
of  Kleinberg, Kaplan, Wolff & Cohen, P.C. which performs legal services for the
Company from time to time.
 
     In August  1996,  the  Company  entered  into  a  transfer  agreement  (the
'Transfer  Agreement') with PharmaDyn, Inc. ('PharmaDyn'), pursuant to which the
Company transferred certain  intangible assets  having no book  value and  which
were unrelated to any of the Company's products in development to PharmaDyn (the
'Transferred Assets'). Pursuant to the Transfer Agreement, PharmaDyn licensed to
the Company certain rights with respect to sales of pharmaceutical products that
may  result from the Transferred Assets for which the Company will pay royalties
at rates  the  Company believes  are  consistent  with fair  market  value.  The
stockholders  of PharmaDyn  are primarily  the same  as the  stockholders of the
Company immediately  prior to  the consummation  of the  IPO. Messers.  Drapkin,
Hyatt,  Kimmel and Ledley  are members of  the board of  directors of PharmaDyn.
Messrs. Hyatt,  Kimmel  and Lyle beneficially own approximately 11.5%, 10.2% and
13.9% respectively, of the outstanding common stock of PharmaDyn.
 
                                 OTHER MATTERS
 
OTHER BUSINESS FOR MEETING
 
     The  Board of Directors does not know of any matters that will be presented
for action  at the  1997 Annual  Meeting other  than those  described above  and
matters  incident to the conduct of the  meeting. If, however, any other matters
not presently known to management should come before the 1997 Annual Meeting, it
is intended that the shares represented by the accompanying proxy will be  voted
on such matters in accordance with the discretion of the holders of such proxy.
 
APPOINTMENT OF INDEPENDENT AUDITORS
 
     The  Board of Directors has appointed the  firm of Coopers & Lybrand L.L.P.
to audit the  accounts of the  Company with  respect to its  operations for  the
fiscal  year ending on December  31, 1997 and to  perform such other services as
may be required. Should  the firm be  unable to perform  these services for  any
reason,  the  Board  of Directors  will  appoint other  independent  auditors to
perform these services. Coopers & Lybrand L.L.P. served as independent  auditors
of the Company for the fiscal year ending December 31, 1996.
 
COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT OF 1934
 
     Section  16(a) of the Exchange Act requires directors, officers and persons
who beneficially own more than 10% of a registered class of stock of the Company
to file  initial  reports  of ownership  (Form  3)  and reports  of  changes  in
beneficial  ownership (Forms 4 and  5) with the Commission  and the Nasdaq. Such
persons are also  required under the  rules and regulations  promulgated by  the
Commission  to furnish the Company  with copies of all  Section 16(a) forms they
file.
 
     Based solely on a review of the copies of such forms, as amended  furnished
to  the Company, the Company believes that all Section 16(a) filing requirements
applicable to its  directors, officers  and greater than  10% beneficial  owners
were compiled with, except that Mr. Hyatt filed his initial report late.
 
                                       14
 

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STOCKHOLDER PROPOSALS FOR 1998
 
     Any stockholder of the Company who wishes to present a proposal at the next
annual  meeting of  stockholders of  the Company,  and who  wishes to  have such
proposal included in  the Company's proxy  statement for that  meeting, must  in
accordance  with Rule 14a-8 of the Exchange Act, deliver a copy of such proposal
to the Company at Collingwood Plaza,  4900 Route 33, Neptune, New Jersey  07753,
Attention:  Assistant Secretary,  no later than  December 18,  1997; however, if
next year's annual meeting of stockholders is  held on a date more than 30  days
before  or  after  the  corresponding  date  of  the  1997  Annual  Meeting, any
stockholder who  wishes to  have  a proposal  included  in the  Company's  proxy
statement  and proxy for that meeting must deliver a copy of the proposal to the
Company within a  reasonable time  before the  proxy solicitation  is made.  The
Company  reserves  the  right  to  decline to  include  in  the  Company's proxy
statement and proxy  any stockholder's proposal  that does not  comply with  the
rules of the Commission and/or the By-laws for inclusion therein.
 
     See  'Corporate  Governance  -- Meetings  and  Committees of  the  Board of
Directors' and  the By-laws  for notice  procedures to  recommend a  person  for
nomination as a director.
 
ANNUAL REPORT
 
     The  Company's 1996  Annual Report  to Stockholders  accompanies this Proxy
Statement. The 1996 Annual Report to Stockholders does not form any part of  the
materials  for the  solicitation of proxies.  Upon written  request, the Company
will provide stockholders with a copy of its Annual Report on Form 10-K for  the
year ended December 31, 1996 (the 'Form 10-K'), as filed with the Commission and
any  amendments thereto,  without charge. Please  direct written  requests for a
copy of the  Form 10-K,  and any  amendments thereto,  to: Algos  Pharmaceutical
Corporation,  Collingwood  Plaza, 4900  Route  33, Neptune,  New  Jersey, 07753;
Attention: President.
 
                                       15

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<PAGE>

                     Appendix 1 Specimen of Proxy Card

                      ALGOS PHARMACEUTICAL CORPORATION

  The  undersigned  hereby  appoints John W. Lyle and Gary Anthony, each of them
with  full  power  of  substitution,  to act  as  proxy  and  to  represent  the
undersigned at the 1997 annual meeting  of stockholders  and  to vote all shares
of  common stock of Algos Pharmaceutical Corporation  which the  undersigned  is
entitled  to vote and  would possess  ifpersonally  present  at  said meeting to
be  held at the Sheraton Eatontown Hotel & Conference Center,  6 Industrial  Way
East, Eatontown, New Jersey,  07724 on Tuesday, June 10, 1997 at 10:00 a.m., and
at all postponements or  adjournments thereof upon the following matters:

THIS  PROXY IS SOLICITED  ON BEHALF OF  THE BOARD OF DIRECTORS.  THIS PROXY WHEN
PROPERLY EXECUTED WILL BE VOTED IN  THE MANNER DIRECTED HEREIN.  IF NO DIRECTION
IS MADE,  THIS PROXY WILL  BE VOTED FOR  PROPOSAL 1 LISTED ON  THE REVERSE SIDE.
PROXIES  ARE  GRANTED  THE DISCRETION  TO VOTE UPON  ALL OTHER MATTERS  THAT MAY
PROPERLY  BE BROUGHT  BEFORE  THE MEETING  OR  ANY  POSTPONEMENT OR  ADJOURNMENT
THEREOF.

                  (Continued, and to be signed on reverse side)


<PAGE>
<PAGE>
 ................................................................................

[X]  Please Mark
     your votes
     as indicated
     in this
     example.


                FOR     WITHHELD
1. Election                            Nominees: Michael Hyatt
of Directors    [ ]       [ ]                    James R. Ledley

FOR, except vote withheld from the following nominee(s):

- --------------------------------------------------------
The Board of Directors recommends a vote FOR the nominees.


    Mr. Gary Anthony
    Algos Pharmaceutical Corp.                                    Change of
    4900 Highway 33                                        Address/comments
    Neptune, NJ 07753-6825                                  on reverse side  [ ]

                                       I plan to              I do not plan
                                      attend the              to attend the
                                         meeting  [ ]               meeting  [ ]

SIGNATURE(S)                                                 DATE
            ------------------------------------------------     ---------------

NOTE: Please sign exactly as name appears hereon. Joint owners should each sign.
When signing as attorney, executor, administrator, trustee or guardian, please
give full title as such.



                            STATEMENT OF DIFFERENCES
                            ------------------------
               The section symbol shall be expressed as.......'SS'

<PAGE>



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