ALGOS PHARMACEUTICAL CORP
DEF 14A, 1999-04-30
PHARMACEUTICAL PREPARATIONS
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               Section 240.14a-101  Schedule 14A.
          Information required in proxy statement.
                 Schedule 14A Information
   Proxy Statement Pursuant to Section 14(a) of the Securities
                      Exchange Act of 1934
                        (Amendment No.  )
Filed by the Registrant [X]
Filed by a party other than the Registrant [ ]
Check the appropriate box:
[ ]  Preliminary Proxy Statement
[ ]  Confidential, for Use of the Commission Only (as permitted
     by Rule 14a-6(e)(2))
[X]  Definitive Proxy Statement
[ ]  Definitive Additional Materials
[ ]  Soliciting Material Pursuant to Section 240.14a-11(c) or Section
     240.14a-12

             ALGOS PHARMACEUTICAL CORPORATION
 .................................................................
     (Name of Registrant as Specified In Its Charter)


 .................................................................
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of Filing Fee (Check the appropriate box):
[X]  No fee required
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(1)
           and 0-11

     (1) Title of each class of securities to which transaction
           applies:


     ............................................................

     (2)  Aggregate number of securities to which transaction
           applies:


     .......................................................

     (3) Per unit price or other underlying value of transaction
computed pursuant to Exchange Act Rule 0-11 (set forth the amount
on which the filing fee is calculated and state how it was
determined):


     .......................................................

     (4) Proposed maximum aggregate value of transaction:


     .......................................................

     (5)  Total fee paid:


     .......................................................

[ ]  Fee paid previously with preliminary materials.

[ ]  Check box if any part of the fee is offset as provided by
     Exchange Act Rule 0-11(a)(2) and identify the filing for
     which the offsetting fee was paid previously.  Identify the
     previous filing by registration statement number, or the
     Form or Schedule and the date of its filing.

          (1) Amount Previously Paid:

           
          .......................................................

          (2) Form, Schedule or Registration Statement No.:


          .......................................................

          (3) Filing Party:


          .......................................................

          (4) Date Filed:

            
          .......................................................





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                        ALGOS PHARMACEUTICAL CORPORATION
                              1333 CAMPUS PARKWAY
                           NEPTUNE, NEW JERSEY 07753
 
Dear Stockholder:
 
     You are cordially invited to attend the Annual Meeting of Stockholders (the
'1999 Annual Meeting') of ALGOS PHARMACEUTICAL CORPORATION, a Delaware
corporation ('Algos'), to be held on Monday, June 21, 1999, at 3:00 p.m., local
time at Algos Pharmaceutical Corporation, 1333 Campus Parkway, Neptune, New
Jersey, 07753.
 
     At the 1999 Annual Meeting, you will be asked to consider and vote upon the
following matters, all of which are described more completely in the
accompanying Proxy Statement:
 
          1. To elect two persons to Algos' Board of Directors to serve for a
     term of three years and until the election and qualification of their
     respective successors;
 
          2. To approve an amendment of the Company's 1996 Non-Employee Director
     Stock Option Plan in order to increase the number of shares of Common Stock
     authorized for issuance over the term of the Plan by 200,000 shares and to
     increase the number of shares of Common Stock subject to options granted to
     each Non-Employee Director on an annual basis from 5,000 to 10,000; and
 
          3. To transact such other business as may properly come before the
     1999 Annual Meeting and any adjournments or postponements thereof.
 
     THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR EACH OF THE
NOMINEES NAMED IN THE PROXY STATEMENT AND FOR THE PROPOSAL TO AMEND THE 1996
NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN.
 
     Only Stockholders of record at the close of business on April 23, 1999 are
entitled to notice of and to vote at, the 1999 Annual Meeting.
 
     We urge you to review carefully the accompanying Proxy Statement. We hope
you will attend the 1999 Annual Meeting. However, whether or not you plan to
attend the 1999 Annual Meeting, it is important that your shares are
represented. Accordingly, please complete, sign and date the enclosed proxy and
return it in the enclosed prepaid envelope. If you are present at the 1999
Annual Meeting you may, if you wish, withdraw your proxy and vote in person.
 
                                          Very truly yours,

                                          /s/ John W. Lyle
                                          ----------------
                                          John W. Lyle
                                          Chief Executive Officer and President
 
April 30, 1999



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                        ALGOS PHARMACEUTICAL CORPORATION
                              1333 CAMPUS PARKWAY
                           NEPTUNE, NEW JERSEY 07753
 
                            ------------------------
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                      TO BE HELD ON MONDAY, JUNE 21, 1999
 
                            ------------------------
To the Stockholders of
ALGOS PHARMACEUTICAL CORPORATION:
 
     The Annual Meeting of Stockholders (the '1999 Annual Meeting') of ALGOS
PHARMACEUTICAL CORPORATION, a Delaware corporation ('Algos'), will be held at
Algos Pharmaceutical Corporation, 1333 Campus Parkway, Neptune, NJ 07753 on
Monday, June 21, 1999, at 3:00 p.m., local time, for the following purposes:
 
          1. To elect two persons to Algos' Board of Directors to serve for a
     term of three years and until the election and qualification of their
     respective successors;
 
          2. To approve an amendment of the Company's 1996 Non-Employee Director
     Stock Option Plan in order to increase the number of shares of Common Stock
     authorized for issuance over the term of the Plan by 200,000 shares and to
     increase the number of shares of Common Stock subject to options granted to
     each Non-Employee Director on an annual basis from 5,000 to 10,000; and
 
          3. To transact such other business as may properly come before the
     1999 Annual Meeting and any adjournments or postponements thereof.
 
     The election and other matters are more fully described in the accompanying
Proxy Statement which forms a part of this Notice.
 
     The Board of Directors of Algos has fixed the close of business on April
23, 1999 as the record date (the 'Algos Record Date') for the determination of
stockholders entitled to notice of and to vote at the 1999 Annual Meeting or any
adjournments or postponements thereof. Only stockholders of record at the close
of business on the Algos Record Date are entitled to notice of, and to vote at,
the 1999 Annual Meeting and any adjournments or postponements thereof.
 
     THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE FOR EACH OF THE
NOMINEES NAMED IN THE PROXY STATEMENT AND FOR THE PROPOSAL TO AMEND THE 1996
NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN.
 
     Whether or not you plan to attend the 1999 Annual Meeting, please complete,
sign, date and return promptly the enclosed form of proxy. A return envelope is
enclosed for your convenience and requires no postage for mailing in the United
States.
 
                                          By Order of the Board of Directors,

                                          /s/ James R. Ledley
                                          ----------------
                                          James R. Ledley
                                          Assistant Secretary
 
April 30, 1999



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<PAGE>
                        ALGOS PHARMACEUTICAL CORPORATION
                              1333 CAMPUS PARKWAY
                           NEPTUNE, NEW JERSEY 07753
 
- ----------------------------------------------------------
                                PROXY STATEMENT
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS
                            TO BE HELD JUNE 21, 1999
 
- ----------------------------------------------------------
 
                                  INTRODUCTION
 
     This Proxy Statement is furnished to the stockholders of Algos
Pharmaceutical Corporation, a Delaware corporation (the 'Company'), in
connection with the solicitation of proxies on behalf of the Company's Board of
Directors (the 'Board of Directors') to be voted at the 1999 Annual Meeting of
Stockholders (the '1999 Annual Meeting') to be held on Monday, June 21, 1999 at
3:00 p.m., local time at Algos Pharmaceutical Corporation, 1333 Campus Parkway,
Neptune, New Jersey, 07753 or at such other time and place to which the 1999
Annual Meeting may be adjourned, for the purposes set forth in the accompanying
Notice of Meeting. This Proxy Statement and Notice of Meeting and the related
proxy card are first being mailed to stockholders beginning on or about May 27,
1999. The Company's principal executive office is located at 1333 Campus
Parkway, Neptune, New Jersey 07753.
 
                                  RECORD DATE
 
     The Board of Directors has fixed the close of business on April 23, 1999 as
the record date (the 'Record Date') for the 1999 Annual Meeting. Only
stockholders of record on that date are entitled to vote at the meeting in
person or by proxy.
 
                                    PROXIES
 
     John W. Lyle and James R. Ledley were appointed by the Board of Directors
to vote the shares represented by the proxy card. Upon receipt by the Company of
a properly signed and dated proxy card, the shares represented thereby will be
voted in accordance with the instructions on the proxy card. If a stockholder
does not return a signed proxy card, his or her shares cannot be voted by proxy.
Stockholders are urged to mark the boxes on the proxy card to show how their
shares are to be voted. If a stockholder returns a signed proxy card without
marking the boxes, the shares represented by the proxy card will be voted as
recommended by the Board of Directors herein and on the proxy card, for the
election of the persons named under 'Election of Directors' as nominees for
election as Directors of the Company (each a 'Nominee' and, collectively, the
'Nominees') for terms to expire on the date of the third annual meeting of the
Company's stockholders following the 1999 Annual Meeting and for the proposal to
amend the 1996 Non-Employee Director Stock Option Plan. The proxy card also
confers discretionary authority on the proxies to vote on any other matter not
presently known to the management that may properly come before the 1999 Annual
Meeting or any adjournment thereof. Any proxy delivered pursuant to this
solicitation is revocable at the option of the person(s) executing the same (i)
upon receipt by the Company before the proxy is voted of a duly executed proxy
bearing a later date, (ii) by written notice of revocation to the Assistant
Secretary of the Company received before the proxy is voted or (iii) by such
person(s) voting in person at the 1999 Annual Meeting. Duly executed proxies in
the form enclosed, unless properly revoked, will be voted at the 1999 Annual
Meeting. The expenses incidental to the preparation and mailing of this proxy
material are being paid by the Company. The Company will reimburse banks,
brokerage firms and other custodians, nominees and fiduciaries for reasonable
expenses incurred by them in sending proxy materials to stockholders. To assure
that a quorum will be present in person or by proxy at the Annual Meeting, in
addition to the solicitation by mail, proxies may be solicited in person or by
telephone, facsimile or other means by directors, officers or employees of the
Company and by representatives of Georgeson & Company, Inc., a proxy
solicitation firm. The Company has agreed to pay Georgeson & Company, Inc. a fee
of $6,500 plus reasonable expenses for its services.
 


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                       VOTING SHARES AND QUORUM REQUIRED
 
     On the Record Date, the Company had outstanding 17,353,045 shares of Common
Stock, par value $.01 per share (the 'Common Stock'). Holders of Common Stock on
the Record Date (the 'Common Stockholders') are entitled to one vote per share
on all matters submitted to a vote of stockholders. The presence in person or by
proxy of the holders of a majority of the issued and outstanding Common Stock,
excluding Common Stock held by the Company, is necessary to constitute a quorum
at the 1999 Annual Meeting.
 
     The affirmative vote of a plurality of the shares of Common Stock
represented in person or by proxy at the 1999 Annual Meeting is required to
elect the Directors and a majority of the shares of Common Stock represented is
required to approve the proposal to amend the 1996 Non-Employee Director Stock
Option Plan. Business that might have been transacted at the 1999 Annual Meeting
as originally called may be conducted at any adjournment at which the requisite
quorum is present.
 
     Pursuant to the laws of the State of Delaware, the inspectors of the
election will not count shares represented by proxies that reflect abstentions
or 'broker non-votes' (i.e., shares held by brokers or nominees that are
represented at the 1999 Annual Meeting, but with respect to which the broker or
nominee is not empowered to vote on a particular proposal) as votes cast with
respect to the election of Directors, and therefore, neither abstentions nor
broker non-votes will affect the election of Nominees receiving the plurality of
votes. With respect to all other proposals scheduled to come before the 1999
Annual Meeting, abstentions with respect to a particular proposal will have the
effect of a vote against such proposal. Broker non-votes, however, will be
treated as unvoted for purposes of determining approval of such proposal and
will not be counted as votes for or against such proposal.
 
                            MATTERS TO BE VOTED UPON
 
1. ELECTION OF DIRECTORS
 
     The Company's by-laws (the 'By-laws') provide that the Board of Directors
is divided into three classes. Each year the stockholders elect Directors to
succeed those Directors whose terms have expired, and each newly elected
Director will serve for a three-year term.
 
     The Nominees set forth below have been duly nominated to stand for election
as Directors of the Company to serve for a term of three (3) years, or until
their successors are elected and qualified.
 
     Each of the Nominees has indicated a willingness to serve as a member of
the Board of Directors if elected. The Board of Directors recommends a vote FOR
each of the Nominees. If any of the Nominees should become unavailable prior to
the 1999 Annual Meeting, the proxy will be voted for a substituted nominee or
nominees designated by the Board of Directors. The information provided below
with respect to the Nominees is as of the Record Date.
 
                                       2
 


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     To be elected by the Common Stockholders:
 
<TABLE>
<CAPTION>
                                                           PRINCIPAL OCCUPATION AND
NAME                            AGE                            OTHER INFORMATION
- -----------------------------   ---   -------------------------------------------------------------------
<S>                             <C>   <C>
John W. Lyle.................   55    President and Chief Executive Officer and a Director of the Company
                                        since its formation in January 1992. Mr. Lyle served as President
                                        and Chief Executive Officer of OmniCorp Holdings, Inc., in 1991.
                                        Prior to founding the Company, Mr. Lyle was one of the founders
                                        of Osteotech, Inc., a public orthopaedic pharmaceutical company
                                        formed in 1986. He served as Osteotech, Inc.'s Chairman and Chief
                                        Executive Officer from 1989 to 1991 and as President from 1986 to
                                        1989. From 1981 to 1986, Mr. Lyle served as President of
                                        CIBA-GEIGY Corporation's Self-Medication Division. From 1975 to
                                        1981, Mr. Lyle held various positions at Johnson & Johnson. Mr.
                                        Lyle holds a B.S. in Marketing Management and a M.B.A. in General
                                        Management, both from the University of Southern California.
Donald G. Drapkin............   51    Director of the Company since January 1994. Mr. Drapkin has been
                                        Vice Chairman and Director of MacAndrews & Forbes Holdings Inc.,
                                        and various of its affiliates for more than five years. Mr.
                                        Drapkin is a Director of the following corporations which file
                                        reports pursuant to the Securities Exchange Act of 1934, as
                                        amended: Anthracite Capital, Inc., BlackRock Asset Investors,
                                        Cardio Technologies, Inc., The Molson Companies Limited, Playboy
                                        Enterprises, Inc., Revlon, Inc., Revlon Consumer Products
                                        Corporation, VIMRx Pharmaceuticals, Inc. and Weider Nutrition
                                        International, Inc. (On December 27, 1996, Marvel, Marvel
                                        Holdings, Marvel Parent and Marvel III, of which Mr. Drapkin was
                                        a Director on such date, and several subsidiaries of Marvel filed
                                        voluntary petitions for reorganization under Chapter 11 of the
                                        United States Bankruptcy Code.) Mr. Drapkin is a member of the
                                        Compensation and Audit Committees of the Company's Board of
                                        Directors.
</TABLE>
 
CONTINUING DIRECTORS
 
     MICHAEL HYATT, 53, has been a Director of the Company since November 1996.
For more than five years, Mr. Hyatt has been a Senior Managing Director of Bear
Stearns & Co., Inc.
 
     ROGER H. KIMMEL, 52, has been a Director of the Company since July 1996.
Mr. Kimmel has been a partner of the law firm of Latham & Watkins for more than
five years. Mr. Kimmel is also a director of Weider Nutrition International,
Inc. and TSR Paging, Inc. Mr. Kimmel is a member of the Compensation Committee
of the Company's Board of Directors.
 
     JAMES R. LEDLEY, 52, has been a Director of the Company since January 1992.
Mr. Ledley also serves as Assistant Secretary for the Company. Since 1995, he
been a member of the law firm of Kleinberg, Kaplan, Wolff & Cohen, P.C. From
1980 to 1995 he was a member of the law firm of Varet & Fink P.C. (previously
known as Milgrim Thomajan & Lee P.C.). Mr. Ledley is a member of the
Compensation and Audit Committees of the Company's Board of Directors.
 
     DIETER A. SULSER, 50, has been a Director of the Company since May 1995.
Since 1991, Mr. Sulser has served as Head of Investment Banking for the ERB
Group of Companies, based in Zurich, Switzerland. Mr. Sulser is also General
Unifina Holding AG, an affiliate of the ERB Group of Companies.
 
                                       3



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     Messers. Hyatt and Ledley are in the class of Directors whose term will
expire in 2000. Messers. Kimmel and Sulser are in the class of Directors whose
term will expire in 2001.
 
     THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR EACH OF THE NOMINEES NAMED IN
THE PROXY STATEMENT AND PROXIES SOLICITED BY THE BOARD OF DIRECTORS WILL BE
VOTED IN FAVOR OF SUCH NOMINEES UNLESS A STOCKHOLDER HAS INDICATED OTHERWISE ON
THE PROXY.
 
2. AMENDMENT OF THE 1996 NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN
 
     At the 1999 Annual Meeting, the Common Stockholders of the Company will be
asked to consider and vote upon an amendment to increase by 200,000 shares the
aggregate number of shares of Common Stock reserved for issuance under the
Company's 1996 Non-Employee Director Stock Option Plan (the 'Plan') and to
increase the number of shares of Common Stock subject to options granted each
Non-Employee Director on an annual basis by 5,000. The Company's Common
Stockholders have previously approved the Plan. A total of 83,000 shares of
Common Stock were originally reserved for issuance under the Plan when it was
adopted in 1996. By the terms of the Plan, the Plan may be amended by the Board
of Directors from time to time in certain respects with Shareholder approval. As
of January 1, 1999, options to purchase 70,000 shares of Common Stock were
outstanding under the Plan. Accordingly, an increase to the number of available
shares of Common Stock is needed to permit the Company to continue to grant
options to Non-Employee Directors. On March 1, 1999 the Board of Directors voted
to approve an amendment to the Plan to increase by 200,000 shares the aggregate
numbers of shares of Common Stock which may be issued under the Plan and to
increase the number of shares of Common Stock subject to options granted each
Non-Employee Director on an annual basis from 5,000 to 10,000. The Board of
Directors believes that the increase in the number of shares of Common Stock
reserved for issuance under the Plan is advisable to give the Company the
flexibility needed to attract, retain and motivate Non-Employee Directors.
 
     THE BOARD OF DIRECTORS RECOMMENDS APPROVAL OF THE AMENDMENT TO THE PLAN TO
INCREASE BY 200,000 SHARES THE AGGREGATE NUMBER OF SHARES FOR WHICH STOCK
OPTIONS MAY BE GRANTED UNDER THE PLAN AND TO INCREASE THE NUMBER OF SHARES OF
COMMON STOCK SUBJECT TO OPTIONS GRANTED EACH NON-EMPLOYEE DIRECTOR ON AN ANNUAL
BASIS BY 5,000 AND PROXIES SOLICITED BY THE BOARD OF DIRECTORS WILL BE VOTED IN
FAVOR OF SUCH AMENDMENT UNLESS A STOCKHOLDER HAS INDICATED OTHERWISE ON THE
PROXY.
 
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
     The following table sets forth certain information concerning the ownership
of Common Stock by each of the Directors and Nominees, the Company's Chief
Executive Officer, each of the Company's other most highly compensated executive
officers, all Directors and executive officers as a group, and each stockholder
who is known by the Company to own beneficially more than 5% of the outstanding
Common Stock, as of March 31, 1999. Unless otherwise indicated, the address of
each beneficial owner is c/o the Company, 1333 Campus Parkway, Neptune, New
Jersey 07753.
 
     For purposes of the following table, a person or group is deemed to have
'beneficial ownership' of any shares which such person has the right to acquire
within 60 days. For purposes of calculating the percentage of outstanding shares
held by each person named above, any shares which such person has
 
                                       4
 


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<PAGE>
the right to acquire within 60 days are deemed to be outstanding, but not for
the purpose of calculating the percentage ownership of any other person.
 
<TABLE>
<CAPTION>
                                                                  NUMBER OF SHARES     PERCENTAGE OF SHARES
NAME OF BENEFICIAL OWNER                                         BENEFICIALLY OWNED     BENEFICIALLY OWNED
- --------------------------------------------------------------   ------------------    --------------------
 
<S>                                                              <C>                   <C>
DIRECTORS AND EXECUTIVE OFFICERS
     John W. Lyle(a)..........................................        1,689,654                 9.7%
     Frank S. Caruso(b).......................................          392,900                 2.3
     Ronald Goldblum(c).......................................           15,000
     Donald Johnson(d)........................................          132,050                  *
     Terence S. Novak(e)......................................           25,500
     Donald G. Drapkin(f).....................................           26,600                  *
     Michael Hyatt(g).........................................        1,850,890                10.7
     Roger H. Kimmel(h).......................................          925,192                 5.3
     James R. Ledley(i).......................................          122,950                  *
     Dieter A. Sulser(j)......................................          163,550                  *
     Directors and Executive Officers as a group(k)...........        4,687,093                26.6
 
OTHER PRINCIPAL STOCKHOLDERS
     Unifina Holding AG and related investors(l)..............        1,734,700                 9.9
     Karen Lyle(m)............................................        1,689,654                 9.7
     Biotech Target S.A.......................................        1,000,000                 5.8
     Lawrence Canarelli(n)....................................          871,500                 5.0
</TABLE>
 
- ------------
 
 *   Represents less than 1%.
 
 (a) Includes (i) 224,100 shares of Common Stock owned directly by Mr. Lyle,
     (ii) 1,332,466 shares of Common Stock and options to purchase 13,450 shares
     of Common Stock owned by Karen Lyle, wife of Mr. Lyle, as to which Mr. Lyle
     disclaims beneficial ownership, (iii) 38 shares owned by Mr. Lyle's son and
     (iv) options to purchase 119,600 shares of Common Stock owned directly by
     Mr. Lyle, and excludes 660,000 shares of Common Stock held in a trust for
     the benefit of the children of Mr. and Mrs. Lyle, as to which shares Mr.
     Lyle has neither the power of disposition nor the power to vote.
 
 (b) Includes (i) 1,000 shares of Common Stock owned directly by Mrs. Caruso,
     wife of Dr. Caruso, as to which Dr. Caruso disclaims beneficial ownership
     and (ii) 7,200 shares of Common Stock held in a trust for which Dr. Caruso
     serves as trustee and as to which shares Dr. Caruso holds either the sole
     or the shared power of disposition and the power to vote and (iii) options
     to purchase 14,500 shares of Common Stock. Excludes a total of 24,900
     shares held in trust for the benefit of the children of Dr. Caruso, as to
     which shares Dr. Caruso has neither the power of disposition nor the power
     to vote.
 
 (c) Includes options to purchase 15,000 shares of Common Stock.
 
 (d) Includes options to purchase 20,000 shares of Common Stock.
 
 (e) Includes options of purchase 25,000 shares of Common Stock.
 
 (f) Includes (i) 16,600 shares owned directly by Mr. Drapkin and (ii) options
     to purchase 10,000 shares of Common Stock. Excludes a total of 809,244
     shares of Common Stock held in six trusts for the benefit of the children
     of Mr. Drapkin, as to which shares Mr. Drapkin has neither the power of
     disposition nor the power to vote.
 
 (g) Includes (i) 829,751 shares of Common Stock owned directly by Mr. Hyatt,
     (ii) 1,004,473 shares held in trusts for which Mr. Hyatt serves as trustee
     and as to which shares Mr. Hyatt holds either the sole or the shared power
     of disposition or the power to vote and (iii) options to purchase 16,666
     shares of Common Stock, and excludes 221,333 shares of Common Stock held in
     a trust for the benefit of the children of Mr. Hyatt, as to which shares
     Mr. Hyatt has neither the power of disposition nor the power to vote.
 
 (h) Includes (i) 30,000 shares owned directly by Mr. Kimmel, (ii) 878,526
     shares held in trusts for which Mr. Kimmel serves as trustee and as to
     which shares Mr. Kimmel holds either the sole or the shared
 
                                              (footnotes continued on next page)
 
                                       5
 


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(footnotes continued from previous page)
     power of disposition and power to vote and (iii) options to purchase 16,666
     shares of Common Stock and excludes 171,530 shares of Common Stock held in
     trusts for the benefit of Mr. Kimmel's son, as to which shares Mr. Kimmel
     has neither the power of disposition nor the power to vote.
 
 (i) Includes (i) 109,450 shares owned directly by Mr. Ledley, and (ii) a total
     of 3,500 shares of Common Stock held in trusts, as to which shares Mr.
     Ledley holds either the sole or the shared power of disposition and power
     to vote and options to purchase 10,000 shares of Common Stock.
 
 (j) Includes (i) options to purchase 10,000 shares of Common Stock and (ii)
     141,100 shares of Common Stock and 12,450 warrants to purchase shares of
     Common Stock owned directly by Gaby Tschofen Sulser, wife of Mr. Sulser, as
     to which Mr. Sulser disclaims beneficial ownership and excludes 1,734,700
     shares beneficially owned by Unifina Holding AG, as to which shares Mr.
     Sulser disclaims beneficial ownership. Mr. Sulser is the General Manager of
     Unifina Holding AG.
 
 (k) Includes options and warrants to purchase 283,332 shares of Common Stock.
 
 (l) Consists of 1,577,000 shares of Common Stock and 157,700 warrants to
     purchase shares of Common Stock held by EBC Zurich AG. The address of
     Unifina Holding AG is Zurcherstrasse 62; CH 8406, Winterthur, Switzerland
     and the address of EBC Zurich AG is Bellariastrasse 23; CH 8027, Zurich,
     Switzerland. Excludes (i) 166,000 shares of Common Stock and warrants to
     purchase 16,600 shares of Common Stock held by Mr. Rolf P. Erb, Chairman of
     EBC Zurich AG and a member of the board of directors of Unifina Holding AG,
     as to which shares each of Unifina Holding AG and EBC Zurich AG disclaim
     beneficial ownership and (ii) 141,100 shares of Common Stock, warrants to
     purchase 12,450 shares of Common Stock and options to purchase 10,000
     shares of Common Stock beneficially owned by Mr. Sulser, General Manager of
     Unifina Holding AG, as to which shares Unifina Holding AG disclaims
     beneficial ownership.
 
(m) Includes (i) 1,332,466 shares of Common Stock and options to purchase 13,450
    shares of Common Stock, owned directly by Mrs. Lyle and (ii) 224,100 shares
    of Common Stock and options to purchase 119,600 shares of Common Stock owned
    directly by John Lyle, husband of Mrs. Lyle, as to which Mrs. Lyle disclaims
    beneficial ownership, and excludes 660,000 shares of Common Stock held in a
    trust for the benefit of the children of Mr. and Mrs. Lyle, as to which
    shares Mrs. Lyle has neither the power of disposition nor the power to vote.
 
 (n) Includes 660,000 shares of Common Stock deemed to be beneficially owned by
     each of Mrs. Albert and Mr. Canarelli in their shared capacity as trustee
     for a trust as to which shares each of Mrs. Albert and Mr. Canarelli share
     the power of disposition and the power to vote.
 
                                       6
 


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<PAGE>
                               EXECUTIVE OFFICERS
 
     Set forth below are the executive officers of the Company.
 
<TABLE>
<CAPTION>
NAME                                          AGE                         POSITION
- -------------------------------------------   ---   -----------------------------------------------------
<S>                                           <C>   <C>
John W. Lyle...............................   55    President and Chief Executive Officer
Frank S. Caruso, Ph.D. ....................   62    Executive Vice President, Research and Development
Terence S. Novak...........................   42    Executive Vice President, Sales and Marketing
Ronald Goldblum............................   56    Vice President, Clinical Research
William B. Middlekauff.....................   37    Vice President, Business Development and General
                                                      Counsel
George M. Wagner...........................   44    Vice President, Regulatory Affairs
Gary R. Anthony............................   38    Treasurer and Chief Financial Officer
</TABLE>
 
     Dr. Caruso joined the Company in 1994. From 1985 to 1993, Dr. Caruso served
as Vice President, Research & Development at Roberts Pharmaceutical Corporation
with responsibility for worldwide pre-clinical and clinical research and
development activities. From 1980 to 1985, Dr. Caruso served as Director,
Clinical Pharmacology, for Revlon Health Care. From 1963 to 1980, Dr. Caruso
served in various positions at Bristol-Myers Company, including Director,
Clinical Research-Analgesics and Central Nervous System. He holds a Ph.D. and
M.S. in Pharmacology, both from the University of Rochester, School of Medicine
and Dentistry and a B.S. in Biology from Trinity College.
 
     Mr. Novak joined the Company in 1998. From 1995 to 1998, Mr. Novak served
as Vice President of Sales and Marketing, Officer and Board Member at Innovex,
Inc., a contract sales and marketing company. From 1994 to 1995, Mr. Novak
served as Executive Director of Managed Care Sales and Marketing at The
Vanderveer Group. Prior to 1994, Mr. Novak served in various positions at
Bristol-Myers Squibb, including District Manager, Regional Sales Director, and
Senior Director of Corporate Accounts. Mr. Novak holds a a B.S. in Biology from
Muhlenberg College.
 
     Dr. Goldblum joined the Company in 1998. From 1995 to 1998, Dr. Goldblum
served as Vice President, Medical Affairs of Neurobiological Technologies, Inc.
Prior to 1995, Dr. Goldblum served in various positions at Syntex USA, Inc. and
Syntex Laboratories, Inc., including Director, Clinical Investigation. Prior to
joining Syntex, Dr. Goldblum practiced as a Rheumatologist in both hospital and
private settings. Dr. Goldblum holds A.B. and M.D. degrees from Case Western
Reserve University.
 
     Mr. Middlekauff joined the Company in 1998. From 1993 to 1998, Mr.
Middlekauff was an associate with the law firm of Cooley Godward LLP where he
advised life science technology companies on business and legal aspects of
research and development, corporate partnering and licensing, product
commercialization and corporate financing. Mr. Middlekauff holds an A.B. degree
from Brown University and a J.D. from Yale Law School.
 
     Mr. Wagner joined the Company in 1997 as Senior Director of Regulatory
Affairs and has served as Vice President, Regulatory Affairs since 1998. Prior
to joining Algos, Mr. Wagner served as Manager of Regulatory Affairs and later
as Director, Regulatory Affairs for F.H. Faulding & Company an Australian-based
company which develops, markets and manufactures pharmaceutical products in the
United States. Mr. Wagner holds a B.S. degree in Biology from Fairleigh
Dickinson University.
 
     Mr. Anthony joined the Company in 1996. Prior to joining Algos, Mr. Anthony
engaged in the private practice of accounting, providing services to
pharmaceutical companies. From 1987 to 1993, he served as Controller for Roberts
Pharmaceutical Corporation where his responsibilities included financial
reporting and the development and implementation of accounting practices and
internal control systems. Mr. Anthony holds a B.S. in Accounting from Monmouth
College.
 
                                       7
 


<PAGE>

<PAGE>
                             EXECUTIVE COMPENSATION
 
SUMMARY EXECUTIVE COMPENSATION TABLE
 
     The following table sets forth the annual, long-term and other compensation
of the Company's Chief Executive Officer and other most highly compensated
executives whose annual base salaries equal or exceed $100,000:
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                               LONG-TERM COMPENSATION
                                                                           ------------------------------
                                             ANNUAL COMPENSATION                  AWARDS          PAYOUTS
                                     -----------------------------------   --------------------   -------
                                                               OTHER       RESTRICTED   OPTIONS
NAME AND PRINCIPAL                                             ANNUAL        STOCK       (# OF     LTIP      ALL OTHER
  POSITION                  YEAR      SALARY      BONUS     COMPENSATION     AWARDS     SHARES)   PAYOUTS   COMPENSATION
- -------------------------  ------    --------    --------   ------------   ----------   -------   -------   ------------
 
<S>                        <C>       <C>         <C>        <C>            <C>          <C>       <C>       <C>
John W. Lyle
  President & Chief
  Executive Officer......   1998     $300,000    $140,000      --             --          --        --         --
                            1997     $275,000    $137,500      --             --         40,000     --         --
                            1996     $254,000    $127,000      --             --        132,800     --         --
Frank S. Caruso
  Executive Vice
  President Research &
  Development............   1998     $194,250    $ 60,000      --             --         10,000     --         --
                            1997     $185,000    $ 61,050      --             --         24,000     --         --
                            1996     $173,500    $ 57,750      --             --         33,200     --         --
Ronald Goldblum
  Vice President,
  Clinical Research(a)...   1998     $118,500    $ 12,500      --             --         60,000     --         59,395(d)
Donald Johnson
  Senior Vice President,
  Pharmaceutical
  Development(b).........   1998     $143,000       --         --             --         40,000     --         --
                            1997     $137,500    $ 30,000      --             --         20,000     --         --
                            1996     $130,000    $ 20,000      --             --          --        --         --
Terence S. Novak
  Executive Vice
  President, Sales &
  Marketing(c)...........   1998     $147,222    $ 25,000      --             --         83,000     --         --
</TABLE>
 
- ------------
 
 (a) Dr. Goldblum's employment with the Company commenced May 1998.
 
 (b) Dr. Johnson's employment with the Company terminated February 1999.
 
 (c) Mr. Novak's employment with the Company commenced April 1998.
 
 (d) Relocation expense compensation.
 
                     OPTION/SAR GRANTS IN LAST FISCAL YEAR
 
<TABLE>
<CAPTION>
                                                                                     POTENTIAL REALIZABLE VALUE AT
                                                                                     ASSUMED ANNUAL RATES OF STOCK
                                                                                         PRICE APPRECIATION FOR
                                             INDIVIDUAL GRANT                                 OPTION TERM
                          ------------------------------------------------------    --------------------------------
                           NUMBER OF       % OF TOTAL
                           SECURITIES     OPTIONS/SARS    EXERCISE
                           UNDERLYING      GRANTED TO     OR BASE
                          OPTIONS/SARS    EMPLOYEES IN     PRICE      EXPIRATION
NAME                        GRANTED       FISCAL YEAR      ($/SH)        DATE           5% ($)           10% ($)
- -----------------------   ------------    ------------    --------    ----------    --------------    --------------
 
<S>                       <C>             <C>             <C>         <C>           <C>               <C>
John W. Lyle...........       --             --             --           --              --                --
Frank S. Caruso........       10,000              3        $27.88       1/31/06       $  134,807        $  321,265
Ronald Goldblum........       60,000             17        $35.50       1/31/06       $  954,540        $2,141,832
Donald Johnson.........       40,000             11        $27.88       1/31/06       $  539,227        $1,295,019
Terence S. Novak.......       83,000             23        $32.25       1/31/06       $1,230,948        $2,735,087
</TABLE>
 
                                       8
 


<PAGE>

<PAGE>
     The following table sets forth for each of the named executive officers the
value realized from stock options exercised during 1998 and the number and value
of exercisable and unexercisable stock options held at December 31, 1998:
 
      AGGREGATED OPTION EXERCISES IN LAST YEAR AND YEAR END OPTION VALUES
 
<TABLE>
<CAPTION>
                                                                  NUMBER OF SHARES              VALUE OF UNEXERCISED
                                                                   OF UNDERLYING                    IN-THE-MONEY
                                   SHARES                       UNEXERCISED OPTIONS                   OPTIONS
                                 ACQUIRED ON     VALUE      ----------------------------    ----------------------------
                                  EXERCISE      REALIZED    EXERCISABLE    UNEXERCISABLE    EXERCISABLE    UNEXERCISABLE
                                 -----------    --------    -----------    -------------    -----------    -------------
 
<S>                              <C>            <C>         <C>            <C>              <C>            <C>
John W. Lyle..................      --             --         343,700          53,200       $ 8,575,000     $ 1,059,600
Frank S. Caruso...............      --             --          80,900          27,800       $ 1,850,400     $   346,800
Ronald Goldblum...............      --             --          15,000          45,000           --              --
Donald Johnson................      --             --          44,900          40,000       $   754,400     $   110,000
Terence S. Novak..............      --             --          15,000          58,000           --              --
</TABLE>
 
EMPLOYMENT AGREEMENTS
 
     Mr. Lyle's employment agreement with the Company expires on December 31,
2000 and is automatically renewable for successive one-year terms unless
terminated by either Mr. Lyle or the Company. Mr. Lyle's employment agreement
provides that he will be employed as the President and Chief Executive Officer
of the Company and that the Company will use its best efforts to cause him to be
elected to the Board of Directors for the term of the agreement. Mr. Lyle is
entitled to a minimum increase of 8% per year or such greater increase as the
Board of Directors, in its sole discretion, deems appropriate to the preceding
year's base salary and for bonuses for individual accomplishment of key
milestone events in such amounts and on such terms as the Board of Directors may
determine.
 
     Dr. Caruso's employment agreement with the Company expires on December 31,
1999 and is automatically renewable for successive one-year terms unless
terminated by either Dr. Caruso or the Company. Dr. Caruso is entitled to a 5%
increase per year or such greater increase as the Board of Directors, in its
sole discretion, deems appropriate to the preceding year's base salary and is
entitled to receive continuing payments equal to twelve months salary in the
event of his termination by the Company without cause. Dr. Caruso may also
receive bonuses for individual accomplishment of key milestone events in such
amounts and on such terms as the Board of Directors may determine.
 
COMPENSATION OF OUTSIDE DIRECTORS
 
     Non-employee members of the Board of Directors will receive cash
compensation of $1,500 per meeting attended as consideration for their services
as Directors of the Company and are reimbursed for reasonable travel expenses
incurred in connection with their attendance at such meetings. Non-employee
Directors upon first appointment or election to the Board of Directors will
receive an option grant under the Company's 1996 Non-Employee Director Stock
Option Plan to purchase 10,000 shares of Common Stock, at the fair market value
on the date of grant, vesting in one-third installments upon each of the first,
second and third annual meetings of stockholders following the date of grant
subject to the Director's continued Board membership. In addition, on the date
of the first meeting of the Board of Directors in each calendar year, each
non-employee Director will be granted options to purchase 10,000 shares of
Common Stock, adjusted for the 5,000 share increase for which shareholder
approval is sought at the 1999 Annual Meeting, at the fair market value on the
date of grant, which shall vest on the first anniversary of the date of grant.
 
          COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
     Mr. Kimmel and Mr. Ledley are members of the Compensation Committee of the
Company's Board of Directors. See 'Certain Relationships and Related
Transactions' for a description of certain of their business relationships with
the Company.
 
                                       9
 


<PAGE>

<PAGE>
         REPORT OF THE COMPENSATION COMMITTEE ON EXECUTIVE COMPENSATION
 
     Compensation Policy and Company Performance. The executive compensation
program has been designed with the goal of motivating, rewarding and retaining
executives with the level of talent and ability required to guide the Company's
growth, efficiently manage its resources, achieve its long-range business
objectives and successfully maintain its position as a leader in developing a
new generation of proprietary pain management products. The compensation program
provides the means of achieving these goals by creating incentives to
accomplishing short-term and long-term objectives, by rewarding exceptional
performance that contributes to the business and by utilizing competitive base
salaries that recognize a policy of career continuity.
 
     The Company's financial well being is highly dependent upon the success of
its long-term growth strategy. The nature of this strategy requires long-term
and significant investments, which may take years to generate returns to
stockholders. Therefore, executive compensation decisions are oriented toward
long-term corporate performance and may not fluctuate as greatly as year-to-year
corporate financial results.
 
     The fundamental principle of the compensation program is to compensate
executives for their performance and for the level of responsibility
corresponding to their positions. Assessments of both individual and corporate
performance influence compensation levels. The Compensation Committee recognizes
the importance of fostering a performance-based environment that motivates
individual achievement. Thus, executives are regularly given recognition for the
prior year's results, which are not necessarily financial results, and provided
with incentives to augment their successes in the future.
 
     The Compensation Committee makes compensation determinations for all of the
Company's senior management, including the individuals whose compensation is
detailed in this proxy. Compensation decisions for all executives, including
John W. Lyle, the Company's Chief Executive Officer, are based on the criteria
disclosed above.
 
     There are three primary elements of the Company's compensation program:
base salary, bonus payments and awards under the 1994 Option Plan and the 1996
Option Plan (together, the 'Stock Plans').
 
     Base Salaries. A competitive base salary is necessary to the development
and retention of capable management and is consistent with the Company's
long-term goals.
 
     Current base salary levels for executives result from a review of the
Company's business performance and general economic factors. Within this
framework, executive salaries are governed in part by various employment
agreements and are determined based on individual performance, level of
responsibility within the Company and experience.
 
     Bonus Payments. Targeted cash bonus payments are awarded to executives in
recognition of contributions to the business during the prior year. An
executive's contributions to the business are measured, in part, by his or her
success in meeting certain goals established by such executive and the Company's
Chief Executive Officer. The aggregate amount of the bonuses awarded in any
calendar year is determined by reference to the terms of the executive
employment agreements, the Company's competitive position, assessment of
progress in attaining long-term goals and business performance considerations.
Because of the Company's developmental stage, these business performance
considerations do not include traditional measurements such as annual cash flow,
earnings per share and return on investments, but rather, how well the Company
has achieved its targeted developmental goals. None of these measurements is
given a specific weight. No formula was used in determining the aggregate amount
of the bonuses awarded to executives in 1998.
 
     The specific cash bonus an executive receives is dependent on individual
performance and level of responsibility. Assessment of an individual's relative
performance is made annually based on a number of factors, including initiative,
business judgment, knowledge of the industry and management skills.
 
     Awards under the Stock Plans. Awards under the Stock Plans are designed to
promote an identity of interests between management and stockholders. Under the
Stock Plans, the Company's executives are eligible to receive grants of options
to purchase Common Stock at or above fair market value on the date of the grant.
Typically, grants of stock options are subject to a significant vesting period.
This
 
                                       10
 


<PAGE>

<PAGE>
approach is designed to increase long-term stockholder value, as the maximum
benefit of this element of executive compensation is only realized if stock
price appreciation occurs over a number of years.
 
     Awards of stock options were granted to certain executives in 1998 based on
individual performance (determined as described above under ' -- Bonus
Payments') and level of responsibility. Award levels are generally intended to
be sufficient in size to provide a strong incentive for executives to work for
long-term business interests and increase such executives' ownership in the
business. See 'Executive Compensation -- Summary Compensation Table' and
'Executive Compensation -- Option/SAR Grants in Last Fiscal Year.'
 
     Policy on the Deductibility of Compensation. Section 162(m) of the Internal
Revenue Code of 1986 as amended (the 'Code'), limits a public company's federal
income tax deduction for compensation paid in excess of $1,000,000 to any of its
five most highly compensated executive officers. However, certain
performance-based compensation, including awards of stock options, is excluded
from the $1,000,000 limit if specific requirements are met.
 
     While the tax impact of any compensation arrangement is one factor which is
considered by the Compensation Committee, such impact is evaluated in light of
the compensation policies discussed above. The Compensation Committee's
compensation determinations have generally been designed to maximize the
Company's federal income tax deduction for possible application in future years.
However, from time to time compensation may be awarded which is not fully
deductible if it is determined that such award is consistent with the overall
design of the compensation program and in the best interests of the Company and
its stockholders.
 
     Chief Executive Officer Compensation. The Chief Executive Officer's salary
is determined based upon Mr. Lyle's employment agreement and the competitive
salary framework described under ' -- Base Salaries,' above, recognizing the
Company's significant growth and the increasing complexity of its business. The
minimum base salary and annual increases set forth in Mr. Lyle's employment
agreement were determined based on the Board of Directors' judgment concerning
his individual contributions to the business, level of responsibility and career
experience. Although none of these factors were given a specific weight, primary
consideration was given to Mr. Lyle's individual contributions to the business.
No particular formulas or measures were used.
 
     The amount of Mr. Lyle's 1998 bonus payment was established in accordance
with Mr. Lyle's employment agreement, based upon the Company's achievement in
product development, including the completion of three Phase III multi-center
studies of MorphiDex'r' and the subsequent August 1998 filing of a New Drug
Application and preparation for the possible commercialization of MorphiDex'r',
including progress in establishing sales and marketing infrastructure. The bonus
amount fixed in Mr. Lyle's employment agreement reflects Mr. Lyle's level of
responsibility within the organization and overall contributions as Chief
Executive Officer.
 
     Conclusion. The Company has had, and continues to have, an appropriate and
competitive compensation program. The balance of a competitive base salary
position, bonus payments and significant emphasis on long-term incentives is a
foundation designed to build stability and to support the Company's continued
growth. This report is submitted by the members of the Compensation Committee:
 
                             COMPENSATION COMMITTEE
                               Donald G. Drapkin
                                Roger H. Kimmel
                                James R. Ledley
 
THE PRECEDING 'REPORT OF THE COMPENSATION COMMITTEE ON EXECUTIVE COMPENSATION'
AND THE 'STOCK PERFORMANCE CHART' THAT APPEARS IMMEDIATELY HEREAFTER SHALL NOT
BE DEEMED TO BE SOLICITING MATERIAL OR TO BE FILED WITH THE SECURITIES AND
EXCHANGE COMMISSION UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED, OR INCORPORATED BY REFERENCE IN ANY
DOCUMENTS SO FILED.
 
                                       11
 


<PAGE>

<PAGE>
                            STOCK PERFORMANCE CHART
 
     As part of the executive compensation information presented in this Proxy
Statement, the Securities and Exchange Commission (the 'Commission') requires a
comparison of stock performance for the Company with stock performance of a
broad equity market index and an appropriate industry index. The following chart
compares the cumulative total stockholder return on the Common Stock during the
period from September 25, 1996 the effective date of the Company's initial
public offering to December 31, 1998 with the cumulative total return on the
Nasdaq Composite Index and a peer group index of Nasdaq pharmaceutical
companies. The comparison assumes $100 was invested on September 25, 1996 in the
Common Stock and in each of the foregoing indices and assumes reinvestment of
dividends, if any. The stock performance shown on the following chart is not
necessarily indicative of future performance.


                              [PERFORMANCE CHART]

<TABLE>
<S>                                      <C>          <C>         <C>          <C>
                                       9/25/96     12/31/96    12/31/97     12/31/98
Nasdaq Composite Index                 100.00      105.03      128.45       168.89
Peer Group Index                       100.00       98.98      102.20       132.17
Algos Pharmaceutical Corporation       100.00       80.36      214.29       231.11
</TABLE>



                               STOCK OPTION PLANS
 
1994 STOCK OPTION PLAN
 
     Effective January 1994, the Company established the Algos Pharmaceutical
Corporation 1994 Stock Option Plan (the '1994 Option Plan') under which key
employees may be granted options to purchase shares of Common Stock. The 1994
Option Plan is intended to assist the Company in attracting and retaining
employees of outstanding ability and to promote the identification of their
interests with those stockholders of the Company. The Company has reserved a
total of 830,000 shares of Common Stock for issuances under the 1994 Option
Plan. As of December 31, 1998, options to purchase 10,790 shares are available
for future grants.
 
     Unless sooner terminated by the Board of Directors, the 1994 Option Plan
will expire ten years after its inception. The 1994 Option Plan is administered
by the Board of Directors, which has the authority to select eligible employees,
grant options under the plan and determine the terms, price, and form of payment
for each grant. Awards under the 1994 Option Plan will generally be granted at
an exercise price equal to the then fair market value per share of Common Stock.
Options granted under the 1994 Option Plan are generally not transferable except
upon an employee's death, at which time all options that have been granted to
such employee are deemed to be exercisable, subject to certain conditions.
 
1996 STOCK OPTION PLAN
 
     In April 1996, the Company adopted the Algos Pharmaceutical 1996 Stock
Option Plan (the '1996 Option Plan'). The 1996 Option Plan is intended to assist
the Company in attracting and retaining key employees and independent
consultants of outstanding ability and to promote the identification of their
interests with those interests of the stockholders of the Company. The 1996
Option Plan permits the
 
                                       12
 


<PAGE>

<PAGE>
grant of non-qualified stock options and incentive stock options to purchase
shares of Common Stock covering 1,215,000 authorized but unissued or reacquired
shares of Common Stock, subject to adjustment to reflect events such as stock
dividends, stock splits, recapitalizations, mergers or reorganizations of or by
the Company.
 
     Unless sooner terminated by the Board of Directors, the 1996 Option Plan
will expire on January 31, 2006. Such termination will not affect the validity
of any option outstanding under the 1996 Option Plan on the date of termination.
 
     The Compensation Committee administers the 1996 Option Plan which is
intended to satisfy the requirements of Rule 16b-3 under the Securities Exchange
Act of 1934, as amended (the 'Exchange Act'), and Section 162(m) of the Code.
Subject to the terms and conditions of the 1996 Option Plan, the Compensation
Committee has the authority to select the persons to whom grants are made, to
designate the number of shares of Common Stock covered by such grants, to
determine the exercise price of options, to establish the period of
exercisability of options, and to make all other determinations and to take all
other actions necessary or advisable for the administration of the 1996 Option
Plan. Subject to the requirements of the 1996 Option Plan, the dates on which
options become exercisable and on which they expire shall be set forth in
individual option agreements. Such agreements will generally provide that
options expire within one year following the termination of the optionee's
status as an employee or consultant of the Company (or a subsidiary) although
the Compensation Committee may provide that options continue to be exercisable
following a termination without 'Cause' (as defined in the 1996 Option Plan) or
otherwise. The Company also may, in its discretion, provide by the terms of an
option that such option will expire at specified times following, or become
exercisable in full upon the occurrence of certain specified 'extraordinary
corporate events' including a merger, consolidation or dissolution of the
Company, or a sale of substantially all of the Company's assets, but in such
event the Compensation Committee may also give optionees the right to exercise
their outstanding options in full during some period prior to such event, even
though the rights have not yet otherwise become fully exercisable.
Notwithstanding the foregoing, upon a 'Corporate Transaction' (as defined in the
1996 Option Plan), all outstanding options shall become immediately exercisable
if not assumed by the surviving corporation.
 
     Incentive stock options ('Incentive Stock Options') granted under the 1996
Option Plan will be designed to comply with the provisions of the Code and will
be subject to certain restrictions contained in the Code. These restrictions
require that Incentive Stock Options (i) have an exercise price not less than
the fair market value of a share of Common Stock on the date of grant, (ii) may
only be granted to employees, (iii) must expire within a specified period of
time following the optionee's termination of employment and (iv) must be
exercised within ten years after the date of the grant.
 
     In the case of an Incentive Stock Option granted to an individual who owns
(or is deemed to own) at least 10% of the total combined voting power of all
classes of stock of the Company, the exercise price must be at least 110% of the
fair market value of a share of Common Stock on the date of grant and must
expire five years after grant. Furthermore, the 1996 Option Plan provides that
the aggregate fair market value (determined at the time the option is granted)
of shares with respect to which Incentive Stock Options may be exercisable for
the first time during any calendar year, may not exceed $100,000 per employee.
Options for shares, the fair market value of which exceeds the $100,000 per year
limit, will be treated as non-qualified stock options.
 
     Options intended to satisfy the requirements for 'performance-based
compensation' under Section 162(m) of the Code must also have an exercise price
of not less than fair market value on the date granted and must comply with
other limitations and restrictions.
 
     The 1996 Option Plan may be amended by the Compensation Committee, subject
to stockholder approval if such approval is then required by applicable law or
in order for the 1996 Option Plan and options granted thereunder to satisfy the
requirements of Rule 16b-3 under the Exchange Act or Section 162(m) of the Code.
 
     The 1996 Option Plan permits the payment of the option exercise price to be
made in cash (which may include an assignment of the right to receive the cash
proceeds from the sale of Common Stock subject to the option pursuant to a
'cashless exercise' procedure) or, at the discretion of the
 
                                       13
 


<PAGE>

<PAGE>
Compensation Committee, by delivery of shares of Common Stock valued at their
fair market value on the date of exercise or by delivery of other property, or
by a recourse promissory note payable to the Company, or by a combination of the
foregoing. As a condition of exercise, optionees must also provide for the
payment of withholding tax obligations of the Company in connection with such
exercise.
 
     Options granted under the 1996 Option Plan shall not be transferable
otherwise than by will, by the laws of descent and distribution or pursuant to a
qualified domestic relations order (as defined in the Code), and may be
exercised during the optionee's lifetime only by the optionee or, in the event
of the optionee's legal disability, by the optionee's legal representative.
 
1996 NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN
 
     In April 1996, the Company adopted the 1996 Non-Employee Director Stock
Option Plan (the 'Director Plan') covering 283,000 authorized but unissued or
reacquired shares of Common Stock, subject to adjustment to reflect events such
as stock dividends, stock splits, recapitalizations, mergers or reorganizations
of or by the Company. The Director Plan is intended to assist the Company in
attracting and retaining qualified non-employee directors ('Outside Directors').
 
     The Director Plan is administered by the Board of Directors and options
granted under the Director Plan are intended to satisfy the requirements of Rule
16b-3 under the Exchange Act. The Director Plan provides for automatic grants of
non-qualified stock options to purchase 10,000 shares of Common Stock to each
Outside Director at the time of first appointment or election to the Board of
Directors.
 
     The exercise price of the options shall be the fair market value of a share
of Common Stock on the date of grant. Each option shall become exercisable in
cumulative annual installments of one-third on each of the first three annual
meetings of the Company's stockholders following the date of grant so long as
the Outside Director continues to serve as a Director of the Company; provided
however, to the extent permitted by Rule 16b-3, the Board of Directors may
accelerate the exercisability of options upon the occurrence of certain
specified extraordinary corporate transactions or events and provided further,
that in any event, upon the occurrence of a 'Corporate Transaction' of the
Company (as defined in the Director Plan) all outstanding options shall become
immediately exercisable. No portion of an option shall be exercisable after the
tenth anniversary of the date of grant and no portion of an option shall became
exercisable following termination of the Outside Director's services as a
Director of the Company.
 
     Unless sooner terminated by the Board of Directors, the Director Plan will
expire ten years after the date of adoption. Such expiration will not affect the
validity of any option outstanding on the date of termination.
 
     Each Outside Director serving as a Director of the Company at the first
regular meeting of the Board of Directors each calendar year shall be granted an
option to purchase 10,000 shares of Common Stock, which options shall vest on
the anniversary of the date of grant.
 
     The discussion above reflects an amendment of the Director Plan to increase
the number of shares of Common Stock authorized for issuance over the term of
the Plan by 200,000 shares and to increase the number of shares of Common Stock
subject to options granted each Non-Employee Director on an annual basis from
5,000 to 10,000 for which shareholder approval is sought at the 1999 Annual
Meeting.
 
CERTAIN FEDERAL INCOME TAX CONSEQUENCES WITH RESPECT TO OPTIONS UNDER THE 1994
OPTION PLAN,
1996 OPTION PLAN AND THE DIRECTOR PLAN
 
     An optionee generally will not recognize taxable income on the grant of a
non-qualified stock option under the 1994 Option Plan, the 1996 Option Plan or
the Director Plan, but will recognize ordinary income on the exercise of such
option. The amount of income recognized on the exercise of an option generally
will be equal to the excess, if any, of the fair market value of the shares at
the time of exercise over the aggregate exercise price paid for the shares,
regardless of whether the exercise price is paid in cash or in shares or other
property. Where ordinary income is recognized by an optionee in
 
                                       14
 


<PAGE>

<PAGE>
connection with the exercise of an option, the Company generally will be
entitled to a deduction equal to the amount of ordinary income so recognized.
 
     An optionee generally will not recognize taxable income upon either the
grant or exercise of an Incentive Stock Option granted under the 1996 Option
Plan. Generally, upon the sale or other taxable disposition of the shares of the
Common Stock acquired upon exercise of an Incentive Stock Option, the optionee
will recognize long-term capital gain in an amount equal to the excess, if any,
of the amount realized in such disposition over the option exercise price,
provided that no disposition of the shares has taken place within either (a) one
year from the date of exercise or (b) two years from the date of grant of the
Incentive Stock Option. If the shares of the Common Stock are sold or otherwise
disposed of before the end of the one-year and two-year periods specified above,
the difference between the Incentive Stock Option exercise price and the fair
market value of the shares on the date of the Incentive Stock Option's exercise
generally will be taxable as ordinary income; the balance of the amount realized
from such disposition, if any, will be taxed as capital gain. If the shares of
Common Stock are disposed of before the expiration of the one-year and two-year
periods and the amount realized is less than the fair market value of the shares
at the date of exercise, the optionee's ordinary income generally is limited to
the excess, if any, of the amount realized in such disposition over the option
exercise price paid. The Company (or other employer corporation) generally will
be entitled to a tax deduction with respect to an Incentive Stock Option only to
the extent the optionee has ordinary income upon sale or other disposition of
the shares of Common Stock.
 
     The rules governing the tax treatment of options and an optionee's receipt
of shares in connection with such grants are quite technical, so that the above
description of tax consequences is necessarily general in nature and does not
purport to be complete. Moreover, statutory provisions are, of course, subject
to change, as are their interpretations, and their application may vary in
individual circumstances. Finally, the tax consequences under applicable state
law may not be the same as under the federal income tax laws.
 
                              CORPORATE GOVERNANCE
 
MEETINGS AND COMMITTEES OF THE BOARD OF DIRECTORS
 
     The business of the Company is managed under the direction of the Board of
Directors. The Board of Directors meets on a regularly scheduled basis during
the year to review significant developments affecting the Company and to act on
matters requiring approval by the Board of Directors. It also holds special
meetings when an important matter requires action by the Board of Directors
between scheduled meetings. In 1998, the Board of Directors met four times.
 
     The Company has established a standing Audit Committee of the Board of
Directors (the 'Audit Committee'). The Audit Committee meets periodically with
management and the Company's independent auditors to review the activities of
each and to discuss audit matters, financial reporting and the adequacy of
internal corporate controls. Donald G. Drapkin and James R. Ledley currently
serve on the Audit Committee. Michael Hyatt resigned from the Audit Committee in
1998. In 1998, the Audit Committee met one time.
 
     The Company does not have a standing nominating committee. The functions
customarily attributable to a nominating committee are performed by the Board of
Directors as a whole. The Company will consider nominees recommended by
stockholders, although it has not actively solicited recommendations from
stockholders for nominees nor has it established any procedures for this purpose
for the 1999 Annual Meeting other than as set forth in the By-laws. In the
future, stockholders wishing to recommend a person for consideration as a
nominee for election to the Company's Board of Directors can do so in accordance
with the By-laws by giving timely written notice to the Secretary of the
Company, that provides each such nominee's name, appropriate biographical
information and any other information that would be required in a proxy
statement or other filings required to be made in connection with solicitation
of proxies for the election of Directors and the class and the number of shares
of capital stock of the Company that are owned beneficially or of record by the
stockholder making the nomination. Such notice should be accompanied by a
written statement from each nominee consenting to be named as a nominee and to
serve as a Director if elected. To be timely, such notice
 
                                       15
 


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must be delivered to, or if mailed, received at, the Company's executive offices
not less than 60 days nor more than 90 days prior to the anniversary of the
immediately preceding annual meeting of stockholders; provided however, that if
the annual meeting is called for a date that is not within 30 days before or
after such anniversary date, notice by the stockholder in order to be timely
must be so received not later than the close of business on the tenth day
following the earlier of the day on which such notice of the date of the annual
meeting was mailed or public disclosure of the date of the annual meeting was
made.
 
     The Company has established a standing Compensation Committee of the Board
of Directors (the 'Compensation Committee'). The Compensation Committee has had
the authority to approve any offers to potential employees of the Company for
positions of Senior Vice President or above, or positions with compensation
packages consisting of (a) annual salaries of $150,000 or more, (b) grants of
options to purchase 10,000 shares of Common Stock when the grants are below the
fair market value on the date of grant and vest over a period shorter than four
years or (c) grants to purchase more than 10,000 shares of Common Stock
regardless of strike price of the options or the vesting schedule. The
Compensation Committee met once in 1998. Donald G. Drapkin, Roger H. Kimmel and
James R. Ledley currently serve on the Compensation Committee.
 
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
     Mr. Roger H. Kimmel, a Director of the Company is a partner at Latham &
Watkins which performs legal services for the Company from time to time.
 
     Mr. James R. Ledley, a Director of the Company, is a member of the law firm
of Kleinberg, Kaplan, Wolff & Cohen, P.C. which performs legal services for the
Company from time to time.
 
     In August 1996, the Company entered into a transfer agreement (the
'Transfer Agreement') with U.S. Dermatologics, Inc., formerly PharmaDyn, Inc.,
pursuant to which the Company transferred certain intangible assets having no
book value and which were unrelated to any of the Company's products in
development to U.S. Dermatologics, Inc. (the 'Transferred Assets') and received
redeemable preferred stock with an aggregate stated value and liquidation
preference of $2.8 million and all of U.S. Dermatologics, Inc. common stock. The
common stock was subsequently distributed to the Company's stockholders, warrant
holders and certain of its employees. The preferred stock provides for an annual
cumulative dividend of 30%, which may be paid in the form of cash or common
stock, and a share of other earnings. Pursuant to the Transfer Agreement, U.S.
Dermatologics, Inc. licensed to the Company certain rights with respect to sales
of pharmaceutical products that may result from the Transferred Assets for which
the Company will pay royalties at rates the Company believes are consistent with
fair market value. The Company entered into a Services Agreement with U.S.
Dermatologics, Inc. to provide certain consulting and administrative services
for a transitional period. The Services Agreement expired in June 1998. The
Company's charges for services provided amounted to approximately $198,000 which
was paid in 1998. The stockholders of U.S. Dermatologics, Inc. are primarily the
same as the stockholders of the Company immediately prior to the consummation of
the Company's initial public offering. Messrs. Hyatt, Kimmel, Ledley and Sulser
are members of the board of directors of U.S. Dermatologics, Inc. Messrs. Hyatt,
Kimmel and Lyle beneficially own approximately 7%, 5% and 13% respectively, of
the outstanding common stock of U.S. Dermatologics, Inc.
 
                                 OTHER MATTERS
 
OTHER BUSINESS FOR MEETING
 
     The Board of Directors does not know of any matters that will be presented
for action at the 1999 Annual Meeting other than those described above and
matters incident to the conduct of the meeting. If, however, any other matters
not presently known to management should come before the 1999 Annual Meeting, it
is intended that the shares represented by the accompanying proxy will be voted
on such matters in accordance with the discretion of the holders of such proxy.
 
     In addition, in accordance with Rule 14a-4, if Algos has not received
notice of any matter that a stockholder intends to propose for a vote at the
next annual meeting of stockholders 45 days before the
 
                                       16
 


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<PAGE>
date on which the registrant first mails its proxy materials for the 1999 Annual
Meeting or, if the date of the annual meeting has changed more than 30 days from
the prior year within a reasonable time before the registrant mails its proxy
materials for that year, then the proxy solicited by the Board of Directors will
confer discretionary authority to vote on such stockholder proposal on the proxy
holder, without any discussion of the stockholder proposal in the proxy
statement soliciting such proxy and without such matter appearing as a separate
item on the proxy card.
 
     If Algos has received notice of a matter that a stockholder intends to
propose for a vote during the time periods described in the preceding sentence,
if Algos includes in its proxy statement advice on the nature of such mater and
how Algos intends to exercise its discretion to vote on such matter, then the
proxy will confer discretionary authority to vote on such matters unless the
proponent of such proposal provides Algos, within the above time periods, notice
that the proponent intends to deliver a proxy statement and form of proxy to at
least the percentage of stockholders required under applicable law to carry the
proposal, includes a statement to that effect in the proxy materials filed by
the proponent and provides Algos with a statement from a person with knowledge
that the necessary steps have been taken to deliver a proxy statement and form
of proxy to holders of at least the percentage of stockholder required under
applicable law to carry the proposal.
 
APPOINTMENT OF INDEPENDENT AUDITORS
 
     The Board of Directors has appointed the firm of PricewaterhouseCoopers LLP
to audit the accounts of the Company with respect to its operations for the
fiscal year ending on December 31, 1999 and to perform such other services as
may be required. The Board of Directors can appoint other independent auditors
to perform these services. PricewaterhouseCoopers LLP served as independent
auditors of the Company for the fiscal year ending December 31, 1998.
Representatives of PricewaterhouseCoopers LLP are expected to be present at
the 1999 Annual Meeting and to be available to respond to appropriate questions.
 
COMPLIANCE WITH SECTION 16(A) OF THE SECURITIES EXCHANGE ACT OF 1934
 
     Section 16(a) of the Exchange Act requires directors, officers and persons
who beneficially own more than 10% of a registered class of stock of the Company
to file initial reports of ownership (Form 3) and reports of changes in
beneficial ownership (Forms 4 and 5) with the Commission and the Nasdaq. Such
persons are also required under the rules and regulations promulgated by the
Commission to furnish the Company with copies of all Section 16(a) forms they
file.
 
     Based solely on a review of the copies of such forms, as amended furnished
to the Company, the Company believes that all Section 16(a) filing requirements
applicable to its directors, officers and greater than 10% beneficial owners
were complied with.
 
STOCKHOLDER PROPOSALS FOR 2000
 
     Any stockholder of the Company who wishes to present a proposal at the next
annual meeting of stockholders of the Company, and who wishes to have such
proposal included in the Company's proxy statement for that meeting, must in
accordance with Rule 14a-8 of the Exchange Act, deliver a copy of such proposal
to the Company at 1333 Campus Parkway, Neptune, New Jersey 07753, Attention:
Assistant Secretary, no later than December 31, 1999; however, if next year's
annual meeting of stockholders is held on a date more than 30 days before or
after the corresponding date of the 1999 Annual Meeting, any stockholder who
wishes to have a proposal included in the Company's proxy statement and proxy
for that meeting must deliver a copy of the proposal to the Company within a
reasonable time before the proxy solicitation is made. The Company reserves the
right to decline to include in the Company's proxy statement and proxy any
stockholder's proposal that does not comply with the rules of the Commission
and/or the By-laws for inclusion therein.
 
     See 'Corporate Governance -- Meetings and Committees of the Board of
Directors' and the By-laws for notice procedures to recommend a person for
nomination as a director.
 
                                       17
 


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ANNUAL REPORT
 
     The Company's 1998 Annual Report to Stockholders accompanies this Proxy
Statement. The 1998 Annual Report to Stockholders does not form any part of the
materials for the solicitation of proxies. Upon written request, the Company
will provide stockholders with a copy of its Annual Report on Form 10-K for the
year ended December 31, 1998 (the 'Form 10-K'), as filed with the Commission and
any amendments thereto, without charge. Please direct written requests for a
copy of the Form 10-K, and any amendments thereto, to: Algos Pharmaceutical
Corporation, 1333 Campus Parkway, Neptune, New Jersey, 07753; Attention:
President.
 
                                       18




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                                  APPENDIX I


                        ALGOS PHARMACEUTICAL CORPORATION

     The undersigned hereby appoints John W. Lyle and James R. Ledley, each of
them with full power of substitution, to act as proxy and to represent the
undersigned at the 1999 annual meeting of stockholders and to vote all shares
of common stock of Algos Pharmaceutical Corporation which the undersigned is
entitled to vote and would possess if personally present at said meeting to be
held at Algos Pharmaceutical Corporation, 1333 Campus Parkway, Neptune, NJ 07753
on Monday, June 21, 1999 at 3:00 p.m., and at all postponements or adjournments
thereof upon the following matters:

THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS. THIS PROXY WHEN
PROPERLY EXECUTED WILL BE VOTED IN THE MANNER DIRECTED HEREIN. IF NO DIRECTION
IS MADE, THIS PROXY WILL BE VOTED FOR PROPOSALS 1 AND 2 LISTED ON THE REVERSE
SIDE. PROXIES ARE GRANTED THE DISCRETION TO VOTE UPON ALL OTHER MATTERS THAT
MAY PROPERLY BE BROUGHT BEFORE THE MEETING OR ANY POSTPONEMENT OR ADJOURNMENT
THEREOF.

                 (CONTINUED, AND TO BE SIGNED ON REVERSE SIDE)




<PAGE>

<PAGE>


                 Please Detach and Mail in the Envelope Provided

A   [X]   Please mark your
          votes as indicated
          in this example.


                      FOR      WITHHELD

1. Election of       [   ]       [   ]          NOMINEES:  John W. Lyle
   Directors                                               Donald G. Drapkin

FOR, except vote withheld from the following
nominee(s):


- ----------------------------------------
The Board of Directors recommends a vote
FOR the nominees.




                                             FOR       AGAINST     ABSTAIN

2. Amendment of the 1966 Non-Employee       [   ]       [   ]       [   ]
   Director Stock Option Plan.


THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE AMENDMENT.


                                                               Change of  [    ]
                                                        Address/Comments
                                                            note at left

                                 I plan to  [    ]         I do not plan  [    ]
                                attend the                 to attend the
                                   meeting                       meeting


SIGNATURE(S)___________________________________________ DATE____________________

NOTE: Please sign exactly as name appears hereon. Joint owners should each sign.
      When signing as attorney, executor, administrator, trustee or guardian,
      please give full title as such.






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