FIRST SCIENTIFIC INC
8-K, EX-4, 2001-01-12
CHEMICALS & ALLIED PRODUCTS
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              Certificate of Designation of Rights and Preferences
                  for Series 2000-B Convertible Preferred Stock
                                       of
                             First Scientific, Inc.

         Pursuant to Section 151 of the General  Corporation Law of the State of
Delaware, First Scientific,  Inc., a Delaware corporation (the "Company"),  does
hereby certify:

         FIRST:  That  pursuant  to  authority  expressly  vested  in it by  the
Certificate of Incorporation, as amended, of the Company, the Board of Directors
of the Company has adopted the following resolution establishing a new series of
Preferred  Stock of the Company,  consisting  of four  thousand  (4,000)  shares
designated  "Series  2000-B 8% Convertible  Preferred  Stock," with such powers,
designations,  preferences,  and  relative  participating,  optional,  or  other
rights, if any, and the qualifications, limitations, or restrictions thereof, as
are set forth in the resolutions:

                  RESOLVED,   that  the  Company's  Board  of  Directors  hereby
                  approves the  designation and issuance of the Series 2000-B 8%
                  Convertible   Preferred  Stock  according  to  the  terms  and
                  conditions  as set forth in the  Agreement and in the attached
                  Exhibit  A  (Designation  of  Rights  and   Preferences)   and
                  authorizes  and instructs the  Company's  Executive  Officers,
                  Randall  L.  Hales and Jack  Theler to  proceed  in filing the
                  Certificate of  Designation  with the State of Delaware and to
                  take such other action as shall be  appropriate  in connection
                  with  the  issuance  of  the  Series  2000-B  8%   Convertible
                  Preferred Stock

         SECOND: That said resolutions of the directors of the Company were duly
adopted in  accordance  with the  provisions  of Section  151(g) of the  General
Corporation Law of the State of Delaware.

         IN WITNESS WHEREOF, the undersigned hereby affirms,  under penalties of
perjury,  that the  foregoing  instrument is the act and deed of the Company and
that the facts stated therein are true. Dated this 11th day of January, 2001.

                                       First Scientific, Inc.



                                       By: /s/ John L. Theler
                                          -------------------------------------
                                       Name: John L. Theler
                                       Title: Chief Financial Officer


                                        1

<PAGE>


                             FIRST SCIENTIFIC, INC.
                           Certificate of Designation
                    Series 2000-B Convertible Preferred Stock

         First Scientific,  Inc. (the  "Corporation"),  a Delaware  corporation,
hereby  certifies  that  pursuant  to  authority  conferred  upon  the  Board of
Directors of the  Corporation by its Certificate of  Incorporation,  as amended,
and in accordance with the provisions of Section 151 of the General  Corporation
Law of  Delaware  ("DGCL"),  the Board of  Directors  of the  Corporation,  at a
meeting duly called and held  pursuant to Section 141 of the DGCL,  duly adopted
the  following   resolution  providing  for  the  designation  and  the  powers,
preferences, and the qualifications, limitations or restrictions thereof, of the
Series 2000-B Convertible Preferred Stock (the "Series 2000-B Preferred Stock"),
which resolution is as follows:

         RESOLVED,  that  pursuant  to the  authority  vested  in the  Board  of
Directors  of  this  Corporation  in  accordance  with  the  provisions  of  its
Certificate  of  Incorporation,   as  amended,   and  pursuant  to  the  General
Corporation  Law of Delaware,  a series of Preferred Stock of the Corporation is
hereby  created,  such series of  Preferred  Stock to be  designated  the Series
2000-B Preferred Stock, to consist of 4,000 shares,  $0.001 par value per share,
with a stated value of $1,000 per share (the "Stated Value").  The Series 2000-B
Preferred  Stock is being issued  pursuant to the terms and  conditions  of that
certain Securities  Purchase Agreement dated as of May 16, 2000, as amended from
time to time,  and that certain  Agreement  dated as of December 29, 2000 by the
Corporation, which are incorporated herein by this reference (collectively,  the
"Purchase  Agreement").  Capitalized terms used herein and not otherwise defined
shall have the  meanings  given to them in the Purchase  Agreement.  The powers,
preferences and rights, and the  qualifications,  limitations or restrictions of
the Series 2000-B Preferred Stock shall be as follows:

         1. Voting Rights.  Except as otherwise required by applicable law, each
share of Series 2000- B Preferred  Stock issued and  outstanding  shall have the
number of votes equal to the whole number of shares of common  stock,  $.001 par
value,  of the  Corporation  (the "Common Stock") into which the share of Series
2000-B  Preferred Stock is convertible  (with any fractional share determined on
an  aggregate  conversion  basis being  rounded to the nearest  whole  share) as
though such share were immediately convertible.

         2. Dividends.  The holder of Series 2000-B Preferred Stock (hereinafter
the  "Holder")  shall be entitled to receive  (out of legally  available  funds)
cumulative  dividends  equal to 8% per  annum  and  payable  quarterly  within 5
business  days  after  the  last  business  day of each  calendar  quarter  (the
"Dividend  Payment  Date").  From  and  after  the  occurrence  of an  Event  of
Noncompliance,  the Holder of Series 2000-B Preferred Stock shall be entitled to
receive (out of legally available funds)  cumulative  dividends equal to 21% per
annum (the "Default Rate") and payable on each Dividend Payment Date.  Dividends
shall be paid in cash  unless  the  Holder  shall  give  written  notice  to the
Corporation  at least five (5) business days before a Dividend  Payment Date for
which such election is made of Holder's election to receive payment of dividends
in Common Stock at the  Conversion  Price,  as defined  below.  Dividends on the
Series  2000-B  Preferred  Stock shall rank senior to  dividends  payable on all
other  series  or  classes  of  stock of the  Corporation.  Unless  all  accrued
dividends and interest  thereon,  if any, have been paid in full, no dividend on
any other stock shall

                                       -1-

<PAGE>



be  declared  or paid or made,  as the case may be,  or any  moneys  paid to any
sinking or purchase  fund on any other stock for the  redemption  or  repurchase
thereof.  Dividends for less than a full calendar  quarter shall be prorated and
based on the actual number of days elapsed divided by 360 days.

         3.  Redemption.

         A. Optional  Redemption.  The Corporation shall have the right, but not
the  obligation,  exercisable  at any time or from time to time,  until close of
business  on April 2,  2001,  to  redeem  all,  but not less  than  all,  of the
outstanding  shares of Series  2000-B  Preferred  Stock by paying a sum equal to
$6,500,000.00 (the "Optional  Redemption Price"). The Corporation may not redeem
any Series  2000-B  Preferred  Stock  pursuant to this  Paragraph  A, unless all
dividends  accrued  on all of the  outstanding  Series  2000-B  Preferred  Stock
through  December  31,  2000 have been paid in full.  Dividends  for the  period
January 1, 2001 through the date of  redemption  under this  Paragraph A will be
deemed included in the Optional  Redemption  Price stated above. The Corporation
may not  redeem  any  share of  Series  2000-B  Preferred  Stock  which has been
converted  or for  which a  Notice  of  Conversion  has  been  delivered  to the
Corporation  prior to the date notice of redemption is given to the holder under
this Paragraph A.

         B. Mandatory Redemption.  The Corporation shall have the obligation, at
the option of the Holder of Series 2000-B  Preferred Stock, to redeem all of the
outstanding  shares of Series 2000-B  Preferred  Stock by paying a sum per share
equal to 125% of the Stated Value per share,  plus accrued and unpaid  dividends
and  penalties  thereon  through  the  date  of  redemption   (collectively  the
"Mandatory  Redemption  Price") if an Event of Noncompliance (as defined herein)
occurs,  provided  that such  obligation  shall not arise prior to April 3, 2001
unless  either  Randall  L.  Hales has ceased to be  employed  full-time  by the
Corporation  or  Pharmulations,  L.C.  has  ceased  to  provide  services  as  a
consultant to the Corporation.

         C. Notice of Redemption.  The Corporation  shall deliver written notice
of each  redemption,  pursuant to Paragraph A above, of a share of Series 2000-B
Preferred  Stock to the Holder  thereof not less than 48 hours prior to the date
specified in the notice on which such  redemption  is to be made (the  "Optional
Redemption  Date").  A Holder of a share of Series  2000-B  Preferred  Stock may
submit  written  notice of a redemption,  pursuant to Paragraph B above,  to the
Corporation  not less than ten (10) calendar days prior to the date specified in
the notice on which such  redemption  is to be made (the  "Mandatory  Redemption
Date"). Any notice required or permitted to be given under any provision of this
Designation shall be given in writing and delivered personally, by facsimile, or
by  mail,  postage  prepaid,  addressed  to the  Corporation  at  its  principal
executive  offices and to the Holder at the address or  facsimile  number on the
records of the Corporation.  The Holder will have the  responsibility  to notify
the Corporation of its current address and facsimile number at all times.

         D. Redemption Payments. For each share of Series 2000-B Preferred Stock
which is to be redeemed  hereunder,  the  Corporation  shall be obligated on the
applicable  Optional or Mandatory  Redemption  Date to pay to the Holder thereof
(upon  surrender  by such Holder at the  Corporation's  principal  office of the
share certificate) the applicable Optional or Mandatory Redemption Price in cash
or in immediately  available funds. If the Corporation does not make the payment
when due, dividends will accrue on all outstanding Series 2000-B Preferred Stock
from and after the applicable

                                       -2-

<PAGE>



Optional or Mandatory  Redemption  Date at the Default  Rate and the  Conversion
Price  calculated  pursuant  to  Section  4 in  connection  with any  subsequent
conversion of a share of Series 2000-B  Preferred  Stock will be reduced by $.50
per share. If the Corporation  does not pay the Optional  Redemption  Price when
due, the Corporation's right and obligation to make an Optional Redemption shall
cease  and  the  Holder's  right  to a cash  payment  pursuant  to the  Optional
Redemption  shall  cease,  but the  Holder  shall  have a  continuing  right  of
conversion as provided  herein.  If the  Corporation  does not pay the Mandatory
Redemption  Price when due, the  Corporation's  right and  obligation to make an
Mandatory  Redemption  shall  cease  and the  Holder's  right to a cash  payment
pursuant to the Mandatory  Redemption  shall cease,  but the Holder shall have a
continuing right of conversion as provided herein.

         E.  Dividends  After  Optional or  Mandatory  Redemption  Date.  If the
applicable  Optional or Mandatory  Redemption Price to be paid hereunder is paid
in full to the  Holder  of  Series  2000-B  Preferred  Stock  on the  applicable
Optional or Mandatory  Redemption  Date,  the redeemed  shares of Series  2000-B
Preferred Stock shall not be entitled to any dividends  accruing after such date
and on such date, all rights of the Holder of such shares shall cease,  and such
shares shall no longer be deemed to be issued and outstanding.

         4. Conversion.

         Holders of Series 2000-B  Preferred Stock shall have the right, but not
the obligation, to convert the Stated Value and any accrued and unpaid dividends
into fully paid and  nonassessable  shares  (calculated as to each conversion to
the nearest  number of whole shares) of the Common Stock of the  Corporation  at
the  Conversion  Price,  as defined  herein,  subject to  adjustment as provided
herein.  Subject to the limitation for conversion of the Series 2000-B Preferred
Stock on or after April 3, 2001 through  December 31, 2001,  "Conversion  Price"
means 80% of the average of the three  lowest  closing bid prices for the Common
Stock  quoted on the Nasdaq  Stock  Market  system or reported on the NASD's OTC
Bulletin Board during the 15 trading days preceding the conversion date, subject
to a maximum  Conversion  Price of $1.20 per share.  Upon the  occurrence  of an
Event of  Noncompliance,  all of the  Series  2000-B  Preferred  Stock  shall be
immediately convertible notwithstanding any timing or other restrictions imposed
herein and the Conversion  Price shall not be subject to any  limitations on the
minimum imposed herein.  For purposes of this Section 4, the term "fully diluted
capital stock of the Corporation,  after  adjustment" shall be calculated on the
applicable  conversion date as the sum of (x) all issued and outstanding  shares
of Common Stock,  (y) those shares of Common Stock to be issued upon  conversion
of the Series 2000-B Preferred Stock on the applicable  conversion date, and (z)
all  shares  of  Common  Stock  issuable  upon  the  conversion  of  convertible
securities,  excluding the Series 2000-B  Preferred  Stock,  and the exercise of
Common  Stock  purchase  options and warrants  having a  conversion  price or an
exercise  price  less than $.75 per share,  as the case may be. The  calculation
shall exclude shares issuable upon  conversion of convertible  securities or the
exercise of  outstanding  stock options and purchase  warrants with a conversion
price or an exercise price of $.75 or greater, as the case may be.

         Holders  of  Series  2000-B  Preferred  Stock  shall  have  the  right,
exercisable one time only, but not the  obligation,  to convert the Stated Value
of all of the issued and outstanding shares of the Series 2000-B Preferred Stock
on the date of such exercise and all accrued and unpaid dividends

                                       -3-

<PAGE>



thereon  together with cash in an amount which when added to the  aforementioned
Stated Value and dividends  shall equal  $3,652,000.00  into the number of fully
paid and nonassessable shares of the Common Stock which equals 42% of the "fully
diluted capital stock of the Corporation,  after  adjustment,  as defined above.
The  aggregate  number of shares of Common Stock issued upon  conversion  of the
Stated Value of the Series 2000-B Preferred Stock under this paragraph shall not
exceed  42% of the  "fully  diluted  capital  stock  of the  Corporation,  after
adjustment," as defined above.  Conversion under this paragraph may be exercised
on or after April 3, 2001 but not after December 31, 2001.

         In the case of any Series 2000-B  Preferred  Stock which is surrendered
for  conversion,  accrued  and unpaid  dividends  will be payable on such Series
2000-B Preferred Stock with respect to the period ending on the conversion date.
The Holder at its option may elect to receive payment of those dividends in cash
or in Common Stock at the applicable Conversion Price, as provided herein.

         A.  Exercise  of  Conversion  Privilege.  To  exercise  the  conversion
privilege,  the Holder of the Series 2000-B  Preferred  Stock shall surrender to
the Corporation such Series 2000-B Preferred Stock, duly endorsed or assigned to
the Corporation or in blank,  accompanied by written Notice of Conversion to the
Corporation in the form provided in the Series 2000-B  Preferred  Stock that the
Holder elects to convert such Series 2000-B Preferred Stock or, if less than the
entire principal amount thereof is to be converted, the specified portion.

         Series 2000-B  Preferred  Stock shall be deemed to have been  converted
immediately  prior to the  close of  business  on the day of  surrender  of such
Series 2000-B  Preferred  Stock for conversion in accordance  with the foregoing
provisions,  and at such time the rights of the  Holders of such  Series  2000-B
Preferred  Stock as Holders shall cease,  and the person or persons  entitled to
receive  the Common  Stock  issuable  upon  conversion  shall be treated for all
purposes as the record  holder or holders of such Common Stock as and after such
time.

         Within  two  (2)  business  days  after  the   conversion   date,   the
Corporation,  without cost to the Holder,  shall issue and shall  deliver to the
Holder of the converted Series 2000-B Preferred Stock or the person specified by
such  Holder a  certificate  or  certificates  for the number of full  shares of
Common Stock issuable upon  conversion  registered in the name of such Holder or
such other  person as shall have been  specified  by such Holder and all accrued
and unpaid  dividends on the converted  Series 2000-B Preferred Stock or portion
thereof  upon which the Holder does not elect to receive  payment in the form of
Common Stock.

         Upon conversion of Series 2000-B Preferred Stock, the Corporation shall
take all such actions as are  necessary in order to insure that the Common Stock
issuable with respect to such conversion shall be validly issued, fully paid and
nonassessable.

         The  Corporation  shall not close its books  against  the  transfer  of
Common Stock issued or issuable upon conversion of Series 2000-B Preferred Stock
in any manner  which  interferes  with the timely  conversion  of Series  2000-B
Preferred Stock.  The Corporation  shall assist and cooperate with any Holder of
Series  2000-B  Preferred  Stock  required to make any  governmental  filings or
obtain

                                       -4-

<PAGE>



any  governmental  approval  prior to or in  connection  with the  conversion of
Series 2000-B Preferred Stock (including, without limitation, making any filings
required to be made by the Corporation).

         The  Corporation  shall at all times reserve and keep  available out of
its  authorized but unissued  shares of Common Stock,  solely for the purpose of
issuance upon the conversion of Series 2000-B  Preferred  Stock,  such number of
shares of Common Stock  issuable upon the conversion of all  outstanding  Series
2000-B  Preferred Stock. All shares of Common Stock which are so issuable shall,
when issued,  be duly and validly issued,  fully paid and nonassessable and free
from all taxes,  liens and charges.  The Corporation shall take all such actions
as may be  necessary  to assure that all such  shares of Common  Stock may be so
issued without violation of any applicable law or governmental regulation or any
requirements  of any domestic  securities  exchange  upon which shares of Common
Stock may be listed  (except  for  official  notice of  issuance  which shall be
immediately delivered by the Corporation upon each such issuance).

         The conversion  rights of any Series 2000-B  Preferred Stock subject to
redemption  hereunder  shall  terminate on the  Redemption  Date for such Series
2000-B  Preferred  Stock unless the  Corporation has failed to pay to the Holder
thereof the Redemption  Price of such Series 2000-B  Preferred  Stock or portion
thereof (plus all accrued and unpaid  dividends  and  penalties  thereon and any
premium payable with respect thereto).

         B. Adjustment of Conversion Price and Number of Shares upon Issuance of
Common Stock. If and whenever, on or after April 3, 2001, the Corporation issues
or sells (or in  accordance  with  Section 4.C is deemed to have issued or sold)
(specifically  excluding  those  shares of Common Stock issued and sold upon the
exercise  of options  and  warrants  granted  prior to the date of the  Purchase
Agreement),  other than (i) as described in Section 4.D or (ii)  pursuant to the
Purchase  Rights  covered  by  Section  4.I,  any  shares of Common  Stock for a
consideration  per share less than the Fair Market Value (as defined  below) per
share of the Common Stock  determined as of the earlier of (x) the  announcement
of such  issuance  or sale,  or (y) the  date of such  issuance  or  sale,  then
immediately  upon such issuance or sale the Conversion Price shall be reduced to
equal the  amount  determined  by  multiplying  the  Conversion  Price in effect
immediately prior to such issuance or sale by a fraction, the numerator of which
will be the sum of (1) the number of shares of Common Stock  deemed  outstanding
(including Shares deemed  outstanding  pursuant to Section 4.C.(i))  immediately
prior to such issuance or sale  multiplied by the Fair Market Value per share of
the Common Stock  determined as of the date of such  issuance or sale,  plus (2)
the  consideration,  if any,  received by the Corporation  upon such issuance or
sale, and the  denominator  of which will be the product  derived by multiplying
such Fair Market  Value per share of the Common Stock by the number of shares of
Common Stock deemed outstanding (including Shares deemed outstanding pursuant to
Section  4.C.(i))  immediately  after  such  issuance  or sale.  Upon  each such
adjustment of the Conversion  Price hereunder,  the number of Conversion  Shares
issuable  upon exercise of Series  2000-B  Preferred  Stock shall be adjusted to
equal the number of shares  determined by multiplying  the  Conversion  Price in
effect  immediately  prior to such adjustment by the number of Conversion Shares
issuable upon exercise of Series 2000-B  Preferred  Stock  immediately  prior to
such  adjustment  and  dividing  the  product  thereof by the  Conversion  Price
resulting  from  such  adjustment.  For the  purposes  of this  Section  4,  the
calculation  of the number of shares of Common  Stock deemed  outstanding  shall
exclude the Conversion  Shares.  "Fair Market Value" means the closing bid price
of a share of

                                       -5-

<PAGE>



Common Stock quoted on the NASDAQ Stock Market  System or reported on the NASD's
OTC Bulletin Board on the measurement date.

         C.  Effect on  Conversion  Price of Certain  Events.  For  purposes  of
determining the adjusted Conversion Price under Section 4.B, the following shall
be applicable:

                  (i) Issuance of Rights or Options or  Convertible  Securities.
If the  Corporation  in any manner grants any rights or options,  whether or not
immediately  exercisable,  to subscribe  for or to purchase  Common Stock or any
stock or other  securities  convertible  into or  exchangeable  for Common Stock
(including without limitation  convertible Common Stock) (such rights or options
being herein called  "Options" and such  convertible  or  exchangeable  stock or
securities being herein called  "Convertible  Securities") or if the Corporation
in any  manner  issues  or sells  any  Convertible  Securities,  whether  or not
immediately convertible or exchangeable, and the Fair Market Value per share for
which Common Stock issuable upon the exercise of such Options or upon conversion
or exchange of such  Convertible  Securities  is less than the Fair Market Value
per share of the Common  Stock in effect on the earlier of (x) the  announcement
of such grant or  issuance or sale and (y) the date of such grant or issuance or
sale,  then the total maximum number of shares of Common Stock issuable upon the
exercise of such  Options or upon  conversion  or exchange of the total  maximum
amount of such Convertible Securities issuable upon the exercise of such Options
of upon conversion or exchange of such Convertible Securities shall be deemed to
be outstanding and to have been issued and sold by the Corporation for such Fair
Market Value per share.  For purposes of this  paragraph,  the Fair Market Value
per share for which  Common Stock is issuable  upon  exercise of such Options or
upon  conversion or exchange of such  Convertible  Securities"  is determined by
dividing (A) the total amount, if any, received or receivable by the Corporation
as consideration  for the granting of such Options,  plus the minimum  aggregate
amount of additional  consideration payable to the Corporation upon the exercise
of all  such  Options,  plus  in the  case  of  such  Options  which  relate  to
Convertible   Securities,   the   minimum   aggregate   amount   of   additional
consideration,  if any,  payable to the Corporation upon the issuance or sale of
such Convertible  Securities and the conversion or exchange thereof,  by (B) the
total  maximum  number of shares of Common Stock  issuable upon exercise of such
Options or upon the  conversion or exchange of all such  Convertible  Securities
issuable  upon the  exercise  of such  Options.  No  further  adjustment  of the
Conversion  Price shall be made upon the actual issuance of such Common Stock or
of such  Convertible  Securities  upon the  exercise of such Options or upon the
actual  issuance  of such  Common  Stock upon  conversion  or  exchange  of such
Convertible Securities.

                  (ii) Change in Option Price or Conversion  Rate. If either the
purchase price provided for in any Options,  the  additional  consideration,  if
any,  payable  upon  the  issue,  conversion  or  exchange  of  any  Convertible
Securities, or the rate at which any Convertible Securities are convertible into
or exchangeable  for Common Stock shall change at any time to an amount which is
less than the Fair Market Value, then the Conversion Price in effect at the time
of such change shall be adjusted to the  Conversion  Price which would have been
in  effect  at such  time had  such  Options  or  Convertible  Securities  still
outstanding provided for such changed purchase price,  additional  consideration
or changed  conversion rate, as the case may be, at the time initially  granted,
issued or sold and the  number of  Conversion  Shares  shall be  correspondingly
readjusted.


                                       -6-

<PAGE>



         D. Subdivision or Combination of Shares. If the Corporation at any time
subdivides (by any stock split, stock dividend, recapitalization,  or otherwise)
the outstanding shares of Common Stock into a greater number of shares of Common
Stock,  or pays a dividend  or makes a  distribution  to holders of  outstanding
shares of Common  Stock in the form of shares of Common  Stock,  or combines (by
reverse stock split or otherwise) the outstanding  shares of Common Stock into a
smaller number of shares,  the Conversion  Price of the Series 2000-B  Preferred
Stock in effect  immediately  prior to such  event  and the  number of shares of
Common Stock issuable upon conversion of the Series 2000-B Preferred Stock shall
be  proportionately  adjusted so that the Holder of the Series 2000-B  Preferred
Stock  thereafter  surrendered for conversion shall be entitled to receive after
the occurrence of any of the events described the proportionate number of shares
of Common  Stock to which the Holder  would have been  entitled  had such Series
2000-B  Preferred  Stock been exercised  immediately  prior to the occurrence of
such event, such adjustment to become effective immediately after the opening of
business  on  the  day  following  the  date  upon  which  such  subdivision  or
combination or reclassification, as the case may be, becomes effective.

         E.  Liquidation of the  Corporation.  In the event of the  liquidation,
dissolution, or winding up of the Corporation, a notice thereof shall be sent to
the Holder at least 15 days before the record  date  specified  for  determining
holders of the shares of Common Stock entitled to receive any distribution  upon
such liquidation, dissolution, or winding up.

         F.  Consolidation of Corporation.  In the case of any  consolidation or
merger  of the  Corporation  with  or into  another  corporation  (other  than a
consolidation  or merger in which the  Corporation is the surviving  corporation
and which  does not  result  in any  reclassification  or change of  outstanding
shares of the class  issuable upon  conversion  of the Series  2000-B  Preferred
Stock),  or in case of any  sale  or  transfer  to  another  corporation  of the
property of the Corporation as an entirety or substantially as an entirety,  the
Holder of each Series 2000-B  Preferred  Stock then  outstanding  shall have the
right to exercise  such Series  2000-B  Preferred  Stock for the purchase of the
kind and  amount of shares of Common  Stock and other  securities  and  property
receivable upon such consolidation, merger, sale, or transfer by a holder of the
number  of shares  of  Common  Stock  which  would  have  been  issuable  if the
conversion of the Series 2000-B Preferred Stock had occurred  immediately  prior
to such consolidation, merger, sale, or transfer.

         G. Certain Events.  If any event occurs of the type contemplated by the
provisions of this Section 4 but not expressly  provided for by such  provisions
(including,  without  limitation,  the  granting of stock  appreciation  rights,
phantom  stock  rights  or  other  rights  with  equity   features),   then  the
Corporation's  Board of  Directors  shall  exercise  their  reasonable  judgment
consistent  with  the  fundamental  intent  of  such  provisions  in  making  an
appropriate  adjustment  in the  Conversion  Price  and the  number of shares of
Common Stock issuable upon conversion of the Series 2000-B Preferred Stock so as
to protect the rights of the Holder of the Series 2000-B Preferred Stock.

         H. Notices.

                  (i) Immediately  upon any adjustment of the Conversion  Price,
the Corporation  shall give written notice thereof to the Holder,  setting forth
in reasonable detail and certifying the calculation of such adjustment.

                                       -7-

<PAGE>



                  (ii) The  Corporation  shall give written notice to the Holder
at least 30 days prior to the date on which the Corporation  closes its books or
takes a record (A) with respect to any dividend or distribution  upon the Common
Stock, (B) with respect to any pro rata subscription  offer to holders of Common
Stock,   or  (C)  for   determining   rights  to  vote  with   respect   to  any
recapitalization,  reorganization, reclassification, consolidation, merger, sale
of  all  or  substantially  all  of the  Corporation's  assets,  dissolution  or
liquidation.

                  (iii) The  Corporation  shall also give written  notice to the
Holder  at least  30 days  prior  to the  date on  which  any  recapitalization,
reorganization,   reclassification,   consolidation,  merger,  sale  of  all  or
substantially all of the Corporation's assets,  dissolution or liquidation shall
take place.

         I. Purchase Rights.  If at any time the Corporation  grants,  issues or
sells any options, convertible securities or rights to purchase stock, warrants,
securities or other  property pro rata to the record holders of the Common Stock
(the "Purchase Rights"), then the Corporation shall grant, issue or sell (as the
case may be) to the Holder the aggregate Purchase Rights which such Holder would
have  acquired if such  Holder had held the  maximum  number of shares of Common
Stock  issuable  upon  conversion  of all  the  Series  2000-B  Preferred  Stock
immediately  before the date on which a record is taken for the grant,  issuance
or sale of such Purchase  Rights or, if no such record is taken,  the date as of
which the record  holders of Common  Stock are to be  determined  for the grant,
issue or sale of such Purchase Rights.

5. Events of Noncompliance.

         A. Definition. An Event of Noncompliance shall have occurred if:

                  (i) the Corporation  fails to pay on any Dividend Payment Date
the full amount of dividends then accrued on the Preferred Stock, whether or not
such  payments are legally  permissible  or are  prohibited  by any agreement to
which the Corporation is subject;

                  (ii) the  Corporation  fails to make  any  redemption  payment
(whether  following the giving of notice  pursuant to paragraph 3C or otherwise)
with  respect to the  Preferred  Stock which it is  required to make  hereunder,
whether or not such  payment  is legally  permissible  or is  prohibited  by any
agreement to which the Corporation is subject;

                  (iii) the  Corporation  breaches or otherwise fails to perform
or observe any material provision contained herein, in the Purchase Agreement or
in the Related Documents (as defined in the Purchase  Agreement) and (other than
with respect to Section 8.1 or 8.2 of the Purchase  Agreement,  the breach of or
failure to perform  which shall result in an immediate  Event of  Noncompliance)
such failure is not cured within fifteen (15) days after the occurrence thereof;

                  (iv) any  representation or warranty contained in the Purchase
Agreement or required to be furnished to any Holder of Preferred  Stock pursuant
to the Purchase Agreement,  or any information  contained in writing required to
be furnished by the  Corporation  or any  Subsidiary  to any Holder of Preferred
Stock,  is false or  misleading  in any  material  respect  on the date  made or
furnished;

                                       -8-

<PAGE>



                  (v) the Corporation or any Subsidiary  makes an assignment for
the benefit of  creditors  or admits in writing its  inability  to pay its debts
generally  as they  become  due;  or an order,  judgment  or  decree is  entered
adjudicating  the  Corporation or any Subsidiary  bankrupt or insolvent;  or any
order for relief with respect to the  Corporation  or any  Subsidiary is entered
under  the  Federal  Bankruptcy  Code;  or the  Corporation  or  any  Subsidiary
petitions  or  applies  to any  tribunal  for the  appointment  of a  custodian,
trustee,  receiver or liquidator of the  Corporation or any Subsidiary or of any
substantial  part  of the  assets  of the  Corporation  or  any  Subsidiary,  or
commences any proceeding (other than a proceeding for the voluntary  liquidation
and dissolution of any Subsidiary) relating to the Corporation or any Subsidiary
under any bankruptcy,  reorganization,  arrangement, insolvency, readjustment of
debt, dissolution or liquidation law of any jurisdiction;  or the Corporation or
any Subsidiary  takes any action to authorize any of the foregoing;  or any such
petition or application is filed, or any such  proceeding is commenced,  against
the  Corporation or any  Subsidiary  and either (a) the  Corporation or any such
Subsidiary  by any act  indicates  its  approval  thereof,  consent  thereto  or
acquiescence  therein or (b) such  petition,  application  or  proceeding is not
dismissed within 60 days;

                  (vi) any material  provision of the Purchase  Agreement or any
Related  Document  shall at any time for any reason be  declared  to be null and
void, or the validity or enforceability  thereof shall be contested by any party
thereto,  or  a  proceeding  shall  be  commenced  by  the  Corporation  or  any
Governmental  Authority or other  regulatory body having  jurisdiction  over the
Corporation,  seeking to establish the invalidity or enforceability  thereof, or
the  Corporation  shall deny in writing that it has any  liability or obligation
purported to be created under the Purchase Agreement or any Related Document;

                  (vii) (A) any registration  statement required to be filed and
declared  effective by the Corporation  pursuant to the Purchase Agreement shall
not become effective as provided in the Purchase  Agreement or shall cease to be
effective  prior  to the  sale  of all  shares  registered  thereunder,  (B) the
Securities  and Exchange  Commission  shall issue any stop order  suspending the
effectiveness under the Securities Act of any registration statement required to
be filed and  declared  effective  by the  Corporation  pursuant to the Purchase
Agreement or any state securities  commission  suspends the qualification of the
Registrable Securities covered thereby for offering or sale in any jurisdiction,
(C) any proceeding for purposes of either (A) or (B) above is initiated,  or (D)
the Common Stock is suspended  from trading on or the price for the Common Stock
is not quoted or reported on the Nasdaq  Stock  Market  System or the NASD's OTC
Bulletin Board;

                  (viii) the Corporation at any time shall not have reserved and
available authorized but unissued shares of Common Stock, solely for the purpose
of issuance upon conversion of the Preferred Stock, in the number which would be
issuable  upon the  conversion  of all of the issued and  outstanding  Preferred
Stock; or

                  (ix) the  occurrence of a Material  Adverse Change (as defined
in the Purchase Agreement).

         B. Right to Cure.  Any breach,  default in performance of any provision
or  Event of  Noncompliance  of the  Purchase  Agreement  or any of the  Related
Documents which directly affects

                                       -9-

<PAGE>



the Holder's ability to acquire the Preferred  Shares and Warrants,  convert the
Preferred Shares, Exercise the Warrants or sell pursuant to a valid registration
shall be interpreted in accordance  with the terms of the Purchase  Agreement or
any Related Document. Any breach, default in performance of any provision of the
Purchase  Agreement or any of the Related  Documents  or Event of  Noncompliance
which does not  directly  affect the Holder's  ability to acquire the  Preferred
Shares and Warrants, convert the Preferred Shares, Exercise the Warrants or sell
pursuant to a valid registration shall be subject to written notice delivered to
the Corporation and may be cured by the Corporation during the five (5) business
days  after  receipt  of  written  notice of such  breach,  default  or Event of
Noncompliance.

         6.  Liquidation  and Sale  Preferences.  In the  event of  liquidation,
dissolution  or winding up,  whether  voluntary  or  involuntary,  (an "Event of
Liquidation") of the Corporation,  the Holders of Series 2000-B Preferred Stock,
prior and in preference to the holders of the Common Stock, shall be entitled to
receive (i) the Stated Value per share of Series 2000-B  Preferred  (adjusted to
reflect stock dividends,  stock splits or recapitalizations,  if any), plus (ii)
accrued but unpaid  dividends (the  "Liquidation  Preference").  The Liquidation
Preference  shall  rank  senior to all other  series or  classes of stock of the
Corporation.   After  payment  of  the  Liquidation  Preference  and  any  other
preferential  payments  on other  series or classes  of stock  except the Common
Stock,  the Holders of Series 2000-B  Preferred Stock shall have no other rights
to the  remaining  assets of the  Corporation.  If upon the  occurrence  of such
event,  the assets and funds thus  distributed  among the  Holders of the Series
2000- B  Preferred  Stock  shall be  insufficient  to permit the payment to such
Holders of the full aforesaid  preferential  amounts, then the entire assets and
funds of the Corporation legally available for distribution shall be distributed
ratably among the Holders of the Series 2000-B  Preferred Stock in proportion to
the amount of such stock owned by each such Holder.  The Corporation  shall mail
to each Holder of Series 2000-B Preferred Stock, at least twenty (20) days prior
to an Event of Liquidation,  a notice setting forth the date on which such Event
of  Liquidation  is  expected  to become  effective  and the type and  amount of
anticipated  proceeds per share of Common Stock to be  distributed  with respect
thereto and shall afford each such Holder the opportunity to convert such shares
of Series 2000-B Preferred Stock pursuant to Section (iii) (conditional upon the
consummation of such Event of Liquidation) prior to the consummation thereof.

         A  consolidation  or merger of the  Corporation  with or into any other
corporation or  corporations,  or a sale,  conveyance,  or disposition of all or
substantially  all of the assets of the Corporation,  or the effectuation of any
acquisition of the  Corporation by any other entity by means of a transaction or
series of related  transactions  in which more than fifty  percent  (50%) of the
voting power of the Corporation is disposed of (the "Sale"),  shall be deemed to
be an Event of Liquidation;  provided, however, that if Holders of Series 2000-B
Preferred Stock are to receive more than the preferential amounts due them under
the immediately  preceding paragraph in the Sale, the Sale shall not be an Event
of  Liquidation  and  all  Holders  of  Series  2000-B   Preferred  Stock  shall
participate  ratably  with the  holders of Common  Stock and the  holders of any
other series of preferred  stock with similar rights in proportion to the amount
of shares of Common Stock owned by each such holder on an as-converted basis and
shall not be entitled to receive any preferential amounts.

         7. Protective Provisions.  So long as shares of Series 2000-B Preferred
Stock are  outstanding,  the  Corporation  shall not without first obtaining the
approval (by vote or written consent), as

                                      -10-

<PAGE>



provided by law,  of the  Holders of  two-thirds  of the  outstanding  shares of
Series 2000-B Preferred Stock: (a) to alter or change the rights, preferences or
privileges  of the  shares  of  Series  2000-B  Preferred  Stock so as to affect
adversely  the shares of such stock;  (b) to increase the  authorized  number of
shares of Series 2000-B  Preferred  Stock; (c) to create any new class or series
of shares of capital  stock with rights or  preferences  prior to or on a parity
with, or increase the number of shares of, Series 2000-B Preferred Stock; or (d)
to sell or  convey  or  otherwise  dispose  of all or  substantially  all of the
property or business of the  Corporation.  No  repurchases or redemptions of any
other  series  or  class of stock of the  Corporation  while in  default  of any
provision of the Series 2000-B Preferred Stock.

         8. Amendments and Waivers. Series 2000-B Preferred Stock may be amended
only  with  the  written  consent  of the  Holder,  and any  existing  Event  of
Noncompliance may be waived only with the written consent of the Holder.

         RESOLVED,  that the Board of Directors has  determined  that the rights
and preferences of the Series 2000-B Preferred Stock are under the circumstances
presently prevailing, fair and equitable to all the existing stockholders.












             [The remainder of this page intentionally left blank.]

                                      -11-

<PAGE>



         IN WITNESS  WHEREOF,  the  Corporation  has caused its duly  authorized
officers to execute this certificate this 11 day of January, 2001.

                                        FIRST SCIENTIFIC, INC.


                                        By: /S/ Randall L. Hales
                                        Randall L. Hales, President and Chief
                                        Executive Officer


                                        By: /s/ John L. Theler
                                        John L. Theler, Vice President, Chief
                                        Financial Officer, Corporate Secretary

STATE OF UTAH                       )
                                    : ss.
COUNTY OF SALT LAKE                 )

         On January __, 2001,  personally  appeared  before me Randall L. Hales,
personally  known to me (or proved to me on the basis of satisfactory  evidence)
to be the  person  whose  name  is  subscribed  to  the  within  instrument  and
acknowledged  to me that he executed the same in his  authorized  capacity,  and
that by his signature on the instrument the person, or the entity upon behalf of
which the person acted, executed the instrument.

         WITNESS my hand and official seal.
                                        -----------------------------------
                                        NOTARY PUBLIC

STATE OF UTAH                       )
                                    : ss.
COUNTY OF SALT LAKE                 )

         On January __,  2001,  personally  appeared  before me John L.  Theler,
personally  known to me (or proved to me on the basis of satisfactory  evidence)
to be the  person  whose  name  is  subscribed  to  the  within  instrument  and
acknowledged  to me that he executed the same in his  authorized  capacity,  and
that by his signature on the instrument the person, or the entity upon behalf of
which the person acted, executed the instrument.

         WITNESS my hand and official seal.
                                        ------------------------------------
                                        NOTARY PUBLIC


                                      -12-

<PAGE>


                              NOTICE OF CONVERSION


To:      First Scientific, Inc.


         The  undersigned  registered  owner  of this  share  of  Series  2000-B
Preferred  Stock  hereby  exercises  the option to convert  this share of Series
2000-B Preferred Stock, or the portion hereof  designated below, and the accrued
dividends  thereon  designated  below into shares of Common Stock in  accordance
with the terms of the Series 2000-B Preferred Stock, and directs that the shares
issuable and  deliverable  upon this  conversion  be issued and delivered to the
registered owner hereof, unless a different name has been provided below.


Dated:
      -------------------               ----------------------------------------

                                        ------------------------------------
                                        Signature(s)


Complete the following for registration of shares of Common Stock if they are to
be delivered other than to and in the name of the registered owner:

------------------------------------
Name

====================================
Address
------------------------------------
Soc. Sec. or Tax I.D. No.




                                      -13-




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