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<TABLE> <S> <C>
<PAGE>
<ARTICLE> 5
<CIK> 0000927653
<NAME> McKESSON HBOC, INC.
<MULTIPLIER> 1,000
<S> <C>
<PERIOD-TYPE> 6-MOS
<FISCAL-YEAR-END> MAR-31-2001
<PERIOD-START> APR-01-2000
<PERIOD-END> SEP-30-2000
<CASH> 176,400
<SECURITIES> 34,800
<RECEIVABLES> 3,512,700
<ALLOWANCES> 291,300
<INVENTORY> 4,467,500
<CURRENT-ASSETS> 8,069,100
<PP&E> 1,192,100
<DEPRECIATION> 635,500
<TOTAL-ASSETS> 10,548,000
<CURRENT-LIABILITIES> 5,209,900
<BONDS> 1,224,300
195,900
0
<COMMON> 2,900
<OTHER-SE> 3,664,900
<TOTAL-LIABILITY-AND-EQUITY> 10,548,000
<SALES> 19,603,300
<TOTAL-REVENUES> 19,603,300
<CGS> 18,444,600
<TOTAL-COSTS> 19,398,900
<OTHER-EXPENSES> 0
<LOSS-PROVISION> 0
<INTEREST-EXPENSE> 56,100
<INCOME-PRETAX> 212,200
<INCOME-TAX> 83,600
<INCOME-CONTINUING> 125,500
<DISCONTINUED> 0
<EXTRAORDINARY> 0
<CHANGES> 0
<NET-INCOME> 125,500
<EPS-BASIC> 0.44
<EPS-DILUTED> 0.44
</TABLE>
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