INKINE PHARMACEUTICAL CO INC
SC 13G, 1999-02-11
PHARMACEUTICAL PREPARATIONS
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  Schedule 13G

                    Under the Securities Exchange Act of 1934
                              (Amendment No. ___)*



                        InKine Pharmaceutical Company, Inc.
- ------------------------------------------------------------------------------
                                (Name of Issuer)


                                  Common Stock
- ------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    69830P105
- ------------------------------------------------------------------------------
                                 (CUSIP Number)


*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                         (Continued on following pages)


                               Page 1 of 12 Pages


<PAGE>


<TABLE>
<CAPTION>
<S>                                         <C>         <C>
- -----------------------------------                     ------------------------
CUSIP NO. 69830P105                         13 G        Page 2 of 12 Pages
- -----------------------------------                     ------------------------

- --------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Biotechnology Development Fund, LP ("BDF")
                     Tax ID Number:    94-3258409
- --------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)   [ ]        (b)   [X]
- --------------------------------------------------------------------------------
3           SEC USE ONLY
- --------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
- --------------------------------------------------------------------------------
      NUMBER OF           5   SOLE VOTING POWER
        SHARES                1,495,000 shares, except that BioAsia, the general
     BENEFICIALLY             partner of BDF, and Kung,  Leung  and Engleman,
OWNED BY EACH REPORTING       members of  BioAsia  may be deemed to have shared
        PERSON                power to vote these shares.
         WITH
                         ---  --------------------------------------------------
                          6   SHARED VOTING POWER
                              See response to item 5.
                         ---  --------------------------------------------------
                          7   SOLE DISPOSITIVE POWER
                              1,495,000 shares, except that BioAsia, the general
                              partner of BDF, and Kung, Leung and Engleman,
                              members of BioAsia may be deemed to have shared
                              power to dispose of these shares.
                         ---  --------------------------------------------------
                          8   SHARED DISPOSITIVE POWER
                              See response to item 7.
- --------------------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                           1,495,000
- --------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                         N/A             [ ]
- --------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                            6.5%
- --------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*
                                                                             PN
- --------------------------------------------------------------------------------

<FN>
                                       * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>



<PAGE>


<TABLE>
<CAPTION>
<S>                                         <C>         <C>
- -----------------------------------                     ------------------------
CUSIP NO. 69830P105                         13 G        Page 3 of 12 Pages
- -----------------------------------                     ------------------------

- --------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     BioAsia Investments, LLC ("BioAsia")
                     Tax ID Number:    94-3258407
- --------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)   [ ]        (b)   [X]
- --------------------------------------------------------------------------------
3           SEC USE ONLY
- --------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            California
- --------------------------------------------------------------------------------
      NUMBER OF           5   SOLE VOTING POWER
        SHARES                0
      BENEFICIALLY
OWNED BY EACH REPORTING
        PERSON
         WITH
                         ---  --------------------------------------------------
                          6   SHARED VOTING POWER
                              1,495,000  shares, all of which are directly owned
                              by BDF.  BioAsia is the general  partner of BDF
                              and may be deemed to have  shared  power to vote
                              these shares.
                         ---  --------------------------------------------------
                          7   SOLE DISPOSITIVE POWER
                              0
                         ---  --------------------------------------------------
                          8   SHARED DISPOSITIVE POWER
                              1,495,000 shares, all of which are directly owned
                              by BDF.  BioAsia is the general  partner of BDF
                              and may be deemed to have shared power to dispose
                              of these shares.
- --------------------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                           1,495,000
- --------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                            N/A          [ ]
- --------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                            6.5%
- --------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*                                        PN
- --------------------------------------------------------------------------------

<FN>
                                       * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>



<PAGE>


<TABLE>
<CAPTION>
<S>                                         <C>         <C>
- -----------------------------------                     ------------------------
CUSIP NO. 69830P105                         13 G        Page 4 of 12 Pages
- -----------------------------------                     ------------------------

- --------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Frank Kung ("Kung")
                     Tax ID Number:    ###-##-####
- --------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)   [ ]        (b)   [X]
- --------------------------------------------------------------------------------
3           SEC USE ONLY
- --------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
       NUMBER OF          5   SOLE VOTING POWER
        SHARES                0 shares
      BENEFICIALLY
OWNED BY EACH REPORTING
        PERSON
         WITH
                         ---  --------------------------------------------------
                          6   SHARED VOTING POWER
                              1,495,000  shares, all of which are directly owned
                              by BDF.  Kung is a member of BioAsia and may be
                              deemed to have shared power to vote these shares.
                         ---  --------------------------------------------------
                          7   SOLE DISPOSITIVE POWER
                              0 shares
                         ---  --------------------------------------------------
                          8   SHARED DISPOSITIVE POWER
                              1,495,000  shares,  all of which are directly
                              owned by BDF.  Kung is a member of BioAsia and may
                              be deemed to have shared  power to dispose of 
                              these shares.
- --------------------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                           1,495,000
- --------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                           N/A           [ ]
- --------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                            6.5%
- --------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*
                                                                             IN
- --------------------------------------------------------------------------------

<FN>
                                        SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>



<PAGE>


<TABLE>
<CAPTION>
<S>                                         <C>         <C>
- -----------------------------------                     ------------------------
CUSIP NO. 69830P105                         13 G        Page 5 of 12 Pages
- -----------------------------------                     ------------------------

- --------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Anselm Leung ("Leung")
                     Tax ID Number:    ###-##-####
- --------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)   [ ]        (b)   [X]
- --------------------------------------------------------------------------------
3           SEC USE ONLY
- --------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- --------------------------------------------------------------------------------
       NUMBER OF          5   SOLE VOTING POWER
         SHARES               0 shares
      BENEFICIALLY
OWNED BY EACH REPORTING
         PERSON
          WITH
                         ---  --------------------------------------------------
                          6   SHARED VOTING POWER
                              1,495,000 shares, all of which are directly 
                              owned by BDF.  Leung is a member of BioAsia and
                              may be deemed to have shared  power to vote these
                              shares.
                         ---  --------------------------------------------------
                          7   SOLE DISPOSITIVE POWER
                              0 shares
                         ---  --------------------------------------------------
                          8   SHARED DISPOSITIVE POWER
                              1,495,000 shares, all of which are directly owned
                              by BDF.  Leung is a member of BioAsia and may be
                              deemed to have shared power to dispose of these
                              shares.
- --------------------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                           1,459,000
- --------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                             N/A         [ ]
- --------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                            6.5%
- --------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*
                                                                             IN
- --------------------------------------------------------------------------------

<FN>
                                       * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>



<PAGE>


<TABLE>
<CAPTION>
<S>                                         <C>         <C>
- -----------------------------------                     ------------------------
CUSIP NO. 69830P105                         13 G        Page 6 of 12 Pages
- -----------------------------------                     ------------------------

- --------------------------------------------------------------------------------
1           NAME OF REPORTING
            SS OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

                     Edgar Engleman ("Engleman")
                     Tax ID Number:    ###-##-####
- --------------------------------------------------------------------------------
2           CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                      (a)   [ ]        (b)   [X]
- --------------------------------------------------------------------------------
3           SEC USE ONLY
- --------------------------------------------------------------------------------
4           CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- --------------------------------------------------------------------------------
       NUMBER OF          5   SOLE VOTING POWER
         SHARES               0 shares
      BENEFICIALLY
OWNED BY EACH REPORTING
         PERSON
          WITH
                         ---  --------------------------------------------------
                          6   SHARED VOTING POWER
                              1,495,000 shares, all of which are directly owned
                              by BDF.  Engleman is a member of BioAsia and may
                              be deemed to have shared power to vote these
                              shares.
                         ---  --------------------------------------------------
                          7   SOLE DISPOSITIVE POWER
                              0 shares
                         ---  --------------------------------------------------
                          8   SHARED DISPOSITIVE POWER
                              1,495,000 shares, all of which are directly owned
                              by BDF.  Engleman is a member of BioAsia and may
                              be deemed to have shared power to dispose of these
                              shares.
- --------------------------------------------------------------------------------
9           AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH
            REPORTING PERSON                                           1,495,000
- --------------------------------------------------------------------------------
10          CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
            EXCLUDES CERTAIN SHARES*                             N/A         [ ]
- --------------------------------------------------------------------------------
11          PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
                                                                            6.5%
- --------------------------------------------------------------------------------
12          TYPE OF REPORTING PERSON*
                                                                            IN
- --------------------------------------------------------------------------------

<FN>
                                       * SEE INSTRUCTIONS BEFORE FILLING OUT!
</FN>
</TABLE>



<PAGE>


                                                                    Page 7 of 12

ITEM 1(A).        NAME OF ISSUER

                  InKine Pharmaceutical Company, Inc.

ITEM 1(B).        ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES

                  Sentry Park East
                  1720 Walton Road
                  Blue Bell, PA  19422

ITEM 2(A).        NAME OF PERSONS FILING

                  This Statement is filed by Biotechnology Development Fund,
L.P. ("BDF"), BioAsia Investments, LLC ("BioAsia"), Frank Kung ("Kung"), Anselm
Leung ("Leung"), and Edgar Engleman ("Engleman").  The foregoing entities and
individuals are collectively referred to as the "Reporting Persons."

                  BioAsia is the general partner of BDF, and may be deemed to
have indirect beneficial ownership of shares of the issuer directly owned by
BDF.  Kung, Leung, and Engleman are members of BioAsia, and may be deemed to
have indirect beneficial ownership of the shares of the issuer directly owned
by BDF.

                  BioAsia hereby disclaims beneficial ownership of shares of
issuer directly owned by BDF except to the extent of any indirect pecuniary
interest therein.  Kung, Leung, and Engleman hereby disclaim beneficial
ownership of the shares held by BDF except to the extent of any respective
indirect pecuniary interest therein.

ITEM 2(B).        ADDRESS OF PRINCIPAL OFFICE

                  The address for each of the Reporting Persons is:

                  BioAsia Investments, LLC, 575 High Street, Suite 201,
                  Palo Alto, CA 94301

ITEM 2(C)         CITIZENSHIP

                  BDF is a Delaware limited partnership.  BioAsia is a
California limited liability company.  Kung, Leung and Engleman are United
States citizens.

ITEM 2(D) AND (E).    TITLE OF CLASS OF SECURITIES AND CUSIP NUMBER

                  Common Stock
                  CUSIP # 69830P105

ITEM 3.           Not Applicable


<PAGE>


                                                                    Page 8 of 12

ITEM 4.  OWNERSHIP

                  (a)      Amount beneficially owned:

                           See Row 9 of cover page for each Reporting Person.

                  (b)      Percent of Class:

                           See Row 11 of cover page for each Reporting Person.

                  (c)      Number of shares as to which such person has:

                                 (i)    Sole power to vote or to direct the
                                        vote:

                                        See Row 5 of cover page for each
                                        Reporting Person.

                                 (ii)   Shared power to vote or to direct the
                                        vote:

                                        See Row 6 of cover page for each
                                        Reporting Person.

                                 (iii)  Sole power to dispose or to direct the
                                        disposition of:

                                        See Row 7 of cover page for each
                                        Reporting Person.

                                 (iv)   Shared power to dispose or to direct the
                                        disposition of:

                                        See Row 8 of cover page for each
                                        Reporting Person.


ITEM 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

                  Not applicable.

ITEM 6.           OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
                  PERSON.

                  Under certain circumstances set forth in the limited
partnership agreement of BDF and the limited liability company operating
agreement of BioAsia, the general and limited partners of BDF and the members
of BioAsia each may be deemed to have the right to receive dividends from, or
the proceeds from, the sale of shares of the issuer owned by each such entity
of which they are a partner or member, as applicable.


<PAGE>
                                                                    Page 9 of 12

ITEM 7.           IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
                  ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
                  COMPANY

                  Not applicable

ITEM 8.           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

                  Not applicable

ITEM 9.           NOTICE OF DISSOLUTION OF GROUP.

                  Not applicable

ITEM 10.          CERTIFICATION.

                  Not applicable


<PAGE>

                                                                   Page 10 of 12
                                   SIGNATURES

     After reasonable inquiry and to the best of our knowledge and belief, 
we certify that the information set forth in this statement is true, complete
and correct.

Dated:  February 12, 1999


                                        Biotechnology Development Fund, L.P.

                                        By:   BioAsia Investments, LLC
                                        Its:  General Partner


                                              By:  /s/ Frank Kung
                                                 --------------------------
                                                   Frank Kung, Member



                                        BioAsia Investments, LLC


                                        By:  /s/ Frank Kung
                                           -------------------------------
                                             Frank Kung, Member



                                        /s/ Frank Kung
                                        ----------------------------------
                                        FRANK KUNG


                                        /s/ Anselm Leung
                                        ----------------------------------
                                        ANSELM LEUNG


                                        /s/ Edgar Engleman
                                        ----------------------------------
                                        EDGAR ENGLEMAN



<PAGE>


                                                                   Page 11 of 12

                                  EXHIBIT INDEX


                                                                Found on
                                                              Sequentially
Exhibit                                                       Numbered Page
- -------                                                       -------------

Exhibit A:  Agreement of Joint Filing                            Page 12



<PAGE>

                                                                   Page 12 of 12
                                    EXHIBIT A



                            Agreement of Joint Filing

     The undersigned hereby agree that a single Schedule 13G (or any amendment
thereto) relating to the Common Stock of InKine Pharmaceutical Company, Inc.
shall be filed on behalf of each of the undersigned and that this Agreement 
shall be filed as an exhibit to such Schedule 13G.

         Executed this 12th day of February, 1999.


                                        Biotechnology Development Fund, L.P.

                                        By:   BioAsia Investments, LLC
                                        Its:  General Partner


                                              By:  /s/ Frank Kung
                                                 --------------------------
                                                  Frank Kung, Member



                                        BioAsia Investments, LLC


                                        By:  /s/ Frank Kung
                                           -------------------------------
                                             Frank Kung, Member



                                        /s/ Frank Kung
                                        ----------------------------------
                                        FRANK KUNG


                                        /s/ Anselm Leung
                                        ----------------------------------
                                        ANSELM LEUNG


                                        /s/ Edgar Engleman
                                        ----------------------------------
                                        EDGAR ENGLEMAN





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