<PAGE>
FORM 4
[ ] Check box if no ------------------------------------
longer subject to OMB APPROVAL
Section 16. Form 4 or ------------------------------------
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continue. See Instruction 1(b) Expires: December 31, 2001
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U.S. SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934,
Section 17(a) of the Public Utility Holding Company Act of 1935 or
Section 30(f) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person*
Rose, M.D., J.D. Martin
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(Last) (First) (Middle)
InKine Pharmaceutical Company, Inc.
Sentry Park West
1787 Walton Road
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(Street)
Blue Bell, PA 19422
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(City) (State) (Zip)
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2. Issuer Name and Ticker or Trading Symbol
InKine Pharmaceutical Company, Inc. (INKP)
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3. IRS or Social Security Number
of Reporting Person (Voluntary)
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4. Statement for Month/Year | 5. If Amendment, Date of
| Original (Month/Year)
10/2000 |
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6. Relationship of Reporting Person to Issuer (Check all applicable)
[ ] Director [ ] 10% Owner
[X] Officer [ ] Other (specify below)
(give title below)
Senior Vice President, Clinical and Regulatory Affairs
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7. Individual or Joint/Group Reporting
(Check applicable line)
[X] Form Filed by One Reporting Person
[ ] Form Filed by More than One Reporting Person
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TABLE I - Non-Derivative Securities Acquired, Disposed of,
or Beneficially Owned
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<TABLE>
<CAPTION>
<S> <C> <C> <C> <C> <C> <C>
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1. Title of Security | 2. Transaction Date | 3. Transaction Code | 4. Securities Acquired (A) or Disposed
(Instr. 3) | (Month/Day/Year) | (Instr. 8) | of (D) (Instr. 3, 4 & 5)
| | |
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| | | Amount | (A) or| Price
| | | | (D) |
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Common Stock | 10/26/00 | M | 50,000 | A | $1.50
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Common Stock | 10/26/00 | S | 50,000 | D | $9.25
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1. Title of Security | 5. Amount of Securities | 6. Ownership Form: | 7. Nature of Indirect Beneficial
(Instr. 3) | Beneficially Owned at | Direct (D) or | Ownership (Instr. 4)
| End of Month | Indirect (I) |
| (Instr. 3 & 4) | (Instr. 4) |
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Common Stock | | D |
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Common Stock | 0 | D |
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(over)
SEC2270(7-96)
* If the form is filed by more than one reporting person, see Instruction
4(b)(v).
</TABLE>
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FORM 4 (continued)
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TABLE II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
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<TABLE>
<CAPTION>
<S> <C> <C> <C> <C>
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1. Title of Derivative Security | 2. Conversion or | 3. Transaction Date | 4. Transaction | 5. Number of Derivative
(Instr. 3) | Exercise Price of | (Month/Day/Year) | Code (Instr.| Securities Acquired
| Derivative Security | | 8) | (A) or Disposed of
| | | | (D) (Instr. 3, 4 & 5)
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Stock Option (Right to buy) | | | | |
(FN1) | $1.50 | 10/26/00 | M | | 50,000
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</TABLE>
<TABLE>
<CAPTION>
<S> <C> <C> <C> <C> <C>
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1. Title of Derivative Security | 6. Date Exercisable and | 7. Title and Amount of Underlying | 8. Price of Derivative
(Instr. 3) | Expiration Date | Securities (Instr. 3 & 4) | Security (Instr. 5)
| (Month/Day/Year) | |
| | |
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| Date | Expiration | Title | Amount or Number |
| Exercisable | Date | | of Shares |
| | | | |
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Stock Option (Right to buy) | | | Common | |
(FN1) | Presently | 03/01/09 | Stock | 50,000 |
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</TABLE>
<PAGE>
<TABLE>
<CAPTION>
<S> <C> <C> <C> <C> <C>
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1. Title of Derivative Security | 9. Number of Derivative | 10. Ownership Form of Derivative | 11. Nature of Indirect
(Instr. 3) | Securities Beneficially | Security: Direct (D) or | Beneficial Ownership
| Owned at End of Month | Indirect (I) (Instr. 4) | (Instr. 4)
| (Instr. 4) | |
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Stock Option (Right to buy) | | |
(FN1) | 350,000 | D |
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</TABLE>
Explanation of Responses:
(FN1)Pursuant to Section 16 rules, when an insider exercises an option to
purchase common stock (i.e., a "derivative security"), the Reporting Person must
disclose that the derivative security ceases to exist (i.e., is "disposed of")
and that the Reporting Person has acquired the common stock underlying the
derivative security. Section 16 Rules require such disclosure since once the
Reporting Person acquires the shares of common stock which it has the right to
acquire by virtue of the derivative security, the derivative security no longer
exists (i.e.: the Reporting Person cannot exercise this right again and receive
additional stock). Thus, the disposition of the derivative securities listed on
this Table II represent the identical shares which are listed on Table I as
shares acquired under the transaction code "M." (i.e., the Reporting person no
longer has the right to receive such shares since the Report Person has received
such shares).
** Intentional misstatements or omissions of facts constitute Federal Criminal
Violations.
See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
/s/ Robert F. Apple November 10, 2000
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**Signature of Reporting Person Date
Robert F. Apple
as attorney-in-fact for
Martin Rose, M.D., J.D.
Note: File three copies of this Form, one of which must be manually signed. If
space is insufficient, see Instruction 6 for procedure.
Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB number.
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SEC 2270 (7/96)
