VALENTIS INC
DEF 14A, 2000-10-30
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                            SCHEDULE 14A INFORMATION

                  Proxy Statement Pursuant to Section 14(a) of
                      the Securities Exchange Act of 1934

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      /X/        Definitive Proxy Statement
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      / /        Soliciting material pursuant to Rule 14a-11(c) or
                 Rule 14a-12

                          VALENTIS, INC.
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                 (Name of Registrant as Specified In Its Charter)

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           (Name of Person(s) Filing Proxy Statement, if other than the
                                    Registrant)
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                                 VALENTIS, INC.
                                863A MITTEN ROAD
                          BURLINGAME, CALIFORNIA 94010

                            ------------------------

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                        TO BE HELD ON DECEMBER 12, 2000

                             ---------------------

TO THE STOCKHOLDERS OF VALENTIS, INC.:

    NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of
VALENTIS, INC., a Delaware corporation (the "Company"), will be held on Tuesday,
December 12, 2000, at 10:00 a.m. local time at the offices of the Company, 863A
Mitten Road, Burlingame, California 94010 for the following purpose:

        1.  To elect three directors to hold office until the 2003 Annual
    Meeting of Stockholders.

        2.  To approve an amendment to the Valentis, Inc. 1997 Equity Incentive
    Plan (the "Incentive Plan") to increase the aggregate number of shares of
    common stock reserved for issuance thereunder by 2,000,000 shares.

        3.  To approve an amendment to the Valentis, Inc. 1998 Non-Employee
    Directors' Stock Option Plan (the "Directors' Plan") to increase the
    aggregate number of shares of common stock reserved for issuance thereunder
    by 200,000 shares.

        4.  To approve an amendment to the Valentis, Inc. Employee Stock
    Purchase Plan (the "Purchase Plan") to increase the aggregate number of
    shares of common stock reserved for issuance thereunder by 200,000 shares.

        5.  To ratify the selection of Ernst & Young LLP as independent auditors
    of the Company for its fiscal year ending June 30, 2001.

        6.  To transact such other business as may properly come before the
    meeting or any adjournment or postponement thereof.

    The foregoing items of business are more fully described in the Proxy
Statement accompanying this Notice.

    The Board of Directors has fixed the close of business on October 30, 2000,
as the record date for the determination of stockholders entitled to notice of
and to vote at this Annual Meeting and at any adjournment or postponement
thereof.

                                          By Order of the Board of Directors

                                          /s/ Alan C. Mendelson

                                          Alan C. Mendelson
                                          Secretary

Burlingame, California
November 6, 2000

ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON. WHETHER
OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN AND RETURN
THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR
REPRESENTATION AT THE MEETING. A RETURN ENVELOPE (WHICH IS POSTAGE PREPAID IF
MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE. EVEN IF YOU HAVE
GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE
NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER
NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST OBTAIN FROM THE RECORD
HOLDER A PROXY ISSUED IN YOUR NAME.
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                                 VALENTIS, INC.
                                863A MITTEN ROAD
                          BURLINGAME, CALIFORNIA 94010

                            ------------------------

                                PROXY STATEMENT
                       FOR ANNUAL MEETING OF STOCKHOLDERS
                               DECEMBER 12, 2000

                            ------------------------

                 INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

    The enclosed proxy is solicited on behalf of the Board of Directors of
Valentis, Inc., a Delaware corporation (the "Company"), for use at the Annual
Meeting of Stockholders to be held on December 12, 2000, at 10:00 a.m. local
time (the "Annual Meeting"), or at any adjournment or postponement thereof, for
the purposes set forth herein and in the accompanying Notice of Annual Meeting.
The Annual Meeting will be held at the offices of the Company, 863A Mitten Road,
Burlingame, California 94010. The Company intends to mail this proxy statement
and accompanying proxy card on or about November 6, 2000, to all stockholders
entitled to vote at the Annual Meeting.

SOLICITATION

    The Company will bear the entire cost of solicitation of proxies, including
preparation, assembly, printing and mailing of this proxy statement, the proxy
and any additional information furnished to stockholders. Copies of solicitation
materials will be furnished to banks, brokerage houses, fiduciaries and
custodians holding in their names shares of Common Stock beneficially owned by
others to forward to such beneficial owners. The Company has retained Corporate
Investor Communications, Inc. to assist in the proxy solicitation for a fee of
$4,500 plus expenses. In addition, the Company may reimburse persons
representing beneficial owners of Common Stock for their costs of forwarding
solicitation materials to such beneficial owners. Original solicitation of
proxies by mail may be supplemented by telephone, telegram or personal
solicitation by directors, officers or other regular employees of the Company.
No additional compensation will be paid to directors, officers or other regular
employees for such services.

VOTING RIGHTS AND OUTSTANDING SHARES

    Only holders of record of Common Stock at the close of business on
October 30, 2000 will be entitled to notice of and to vote at the Annual
Meeting. At the close of business on October 30, 2000, the Company had
outstanding and entitled to vote 29,450,910 shares of Common Stock.

    Each holder of record of Common Stock on such date will be entitled to one
vote for each share held on all matters to be voted upon at the Annual Meeting.

    All votes will be tabulated by the inspector of election appointed for the
meeting, who will separately tabulate affirmative and negative votes,
abstentions and broker non-votes. The inspector will also determine whether or
not a quorum is present. In general, Delaware law provides that a quorum
consists of a majority of the shares entitled to vote and present in person or
represented by proxy. Abstentions will be counted towards the tabulation of
votes cast on proposals presented to the stockholders and will have the same
effect as negative votes. Broker non-votes are counted towards a quorum, but are
not counted for any purpose in determining whether a matter has been approved.
Directors will be elected by a plurality of the votes cast that are present in
person or represented by proxy. Abstentions, withheld votes and broker non-votes
will not affect the election of directors. All
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other proposals require the favorable vote of the majority of the votes present
in person or represented by proxy and entitled to vote on a particular proposal.

    Any proxy that is returned using the form of proxy enclosed and which is not
marked as to a particular item will be voted as follows: (1) FOR the election of
all nominees for directors named in the proxy; (2) FOR the approval of the
amendment to the Incentive Plan to increase the number of shares reserved for
issuance thereunder by 2,000,000 shares; (3) FOR the approval of the amendment
to the Directors' Plan to increase the number of shares reserved for issuance
thereunder by 200,000 shares; (4) FOR the approval of the amendment to the
Purchase Plan to increase the number of shares reserved for issuance thereunder
by 200,000 shares; (4) FOR ratification of the appointment of Ernst & Young LLP
as independent auditors of the Company for its fiscal year ending June 30, 2001,
and (5) as the proxy holders deem advisable, on other matters that may come
before the meeting, as the case may be with respect to the item not marked. The
Company believes that the tabulation procedures to be followed by the inspector
are consistent with the general statutory requirements in Delaware concerning
voting of shares and determination of a quorum.

REVOCABILITY OF PROXIES

    Any person giving a proxy pursuant to this solicitation has the power to
revoke it at any time before it is voted. It may be revoked by filing with the
Secretary of the Company at the Company's principal executive office, 863A
Mitten Road, Burlingame, California 94010, a written notice of revocation or a
duly executed proxy bearing a later date, or it may be revoked by attending the
meeting and voting in person. Attendance at the meeting will not, by itself,
revoke a proxy.

STOCKHOLDER PROPOSALS TO BE PRESENTED AT THE NEXT ANNUAL MEETING

    Proposals of stockholders that are intended to be presented at the Company's
2001 Annual Meeting of Stockholders must be received by the Company not later
than July 10, 2001, in order to be included in the proxy statement and proxy
relating to that Annual Meeting. Stockholders are also advised to review the
Company's Bylaws, which contain additional requirements with respect to advance
notice of stockholder proposals and director nominations.

                                   PROPOSAL 1
                             ELECTION OF DIRECTORS

    The Company's Restated Certificate of Incorporation and Bylaws provide that
the Board of Directors shall be divided into three classes, each class
consisting, as nearly as possible, of one-third of the total number of
directors, with each class having a three-year term. Vacancies on the Board may
be filled only by persons elected by a majority of the remaining directors. A
director elected by the Board to fill a vacancy (including a vacancy created by
an increase in the Board of Directors) shall serve for the remainder of the full
term of the class of directors in which the vacancy occurred and until such
director's successor is elected and qualified.

    The Board of Directors is presently composed of eight members. There are
three directors in the class whose term of office expires in 2000. One of the
nominees has served on the Board of Directors since March 1995. One of the
nominees was previously on the board of GeneMedicine, Inc., and has served on
the Board of the Company since the Company and GeneMedicine merged in
March 1999. The third nominee was appointed by the Board in May 2000. If elected
at the Annual Meeting, each of the nominees would serve until the 2003 annual
meeting and until his successor is elected and has qualified, or until such
director's earlier death, resignation or removal.

    Directors are elected by a plurality of the votes present in person or
represented by proxy and entitled to vote at the meeting. Shares represented by
executed proxies will be voted, if authority to do so is not withheld, for the
election of the three nominees named below. In the event that any nominee

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should be unavailable for election as a result of an unexpected occurrence, such
shares will be voted for the election of such substitute nominee as management
may propose. Each person nominated for election has agreed to serve if elected,
and management has no reason to believe that any nominee will be unable to
serve.

    Set forth below is certain biographical information, including age as of
October 10, 2000, for each person nominated and each person whose term of office
as a director will continue after the Annual Meeting:

NOMINEES FOR ELECTION FOR A THREE-YEAR TERM EXPIRING AT THE 2003 ANNUAL MEETING
  OF STOCKHOLDERS

RAJU KUCHERLAPATI, PH.D.

    Raju Kucherlapati, Ph.D., 57, has served as a director of the Company since
March 1995. Dr. Kucherlapati has served as the Lola and Saul Kramer Professor
and Chairman of the Department of Molecular Genetics at Albert Einstein College
of Medicine since 1989. He was a founder of both Cell Genesys, Inc., a
biotechnology company and Millennium Pharmaceuticals, Inc., a biopharmaceutical
company ("Millennium"). He serves on the boards of directors of Abgenix, Inc., a
biopharmaceutical company, and Millennium. Dr. Kucherlapati received his Ph.D.
from the University of Illinois.

BERT W. O'MALLEY, M.D.

    Bert W. O'Malley, M.D., 63, has served as a director of the Company since
March 1999. Previously, Dr. O'Malley was one of GeneMedicine's founders and
served as a director of GeneMedicine from April 1998 to March 1999.
Dr. O'Malley has been Chairman of the Department of Cell Biology at Baylor
College of Medicine and a Director of the Baylor Center for Population Research
and Reproductive Biology since 1973. He is a member of the National Academy of
Science and the Institute of Medicine and is the author of more than 500
scientific publications. Dr. O'Malley's scientific work has included major
achievements in the areas of medical endocrinology and reproduction with
potentially broad application to the diagnosis of human genetic diseases and the
treatment of breast and prostatic cancer. His work includes the invention of the
Company's proprietary GeneSwitch-TM- technology for regulation of the
therapeutic protein produced by a gene medicine. Dr. O'Malley holds a B.S. and a
M.D. degree from the University of Pittsburgh.

MARK MCDADE

    Mark McDade, 45, has served as a director of the Company since May 2000. He
joined as a director of the Company replacing Russell Hirsch, M.D., Ph.D.,
general partner at the Mayfield Fund. Mr. McDade is President and Chief
Operating Officer of Corixa Corporation. As a co-founder of Corixa in
September 1994, he has served as its COO since that company's inception. Prior
to Corixa, Mr. McDade held various management positions at Boehringer Mannheim
and Sandoz Ltd. Mr. McDade earned an M.B.A. from the Harvard University Graduate
School of Business and a B.A. from Dartmouth College.

                       THE BOARD OF DIRECTORS RECOMMENDS
              A VOTE IN FAVOR OF EACH NAMED NOMINEE IN PROPOSAL 1.

DIRECTORS CONTINUING IN OFFICE UNTIL THE 2001 ANNUAL MEETING OF STOCKHOLDERS

BENJAMIN F. MCGRAW III, PHARM.D.

    Benjamin F. McGraw, III, Pharm.D., 51, is the Chairman, President and Chief
Executive Officer of the Company. He joined Megabios in 1994 and merged that
company with GeneMedicine to form Valentis. Dr. McGraw then merged Valentis and
PolyMASC Pharmaceuticals, plc. in August of 1999.

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Prior to Megabios, Dr. McGraw gained experience in R&D as Vice-President,
Development for Marion and Marion, Merrell Dow; in Business Development as
Corporate Vice-President, Corporate Development at Allergan, Inc.; and in
finance as President of Carerra Capital Management. Dr. McGraw also serves on
the board of directors of ISTA Pharmaceuticals. Dr. McGraw received his Doctor
of Pharmacy from the University of Tennessee Center for the Health Sciences,
where he also completed a clinical practice residency.

ARTHUR M. PAPPAS

    Arthur M. Pappas, 53, has served as a director of the Company since
March 1999. From January 1995 to March 1999, Mr. Pappas served as a director of
GeneMedicine. Mr. Pappas is Chairman and Chief Executive Officer of A. M.
Pappas & Associates, LLC an international consulting, investment and venture
company that works with life science companies, products and related
technologies. Mr. Pappas is a director of publicly-traded Quintiles
Transnational Corp., a contract research, sales and marketing organization,
Embrex, Inc., a research and development company specializing in poultry
in-the-egg delivery systems, KeraVision, Inc., a company developing products for
reversible vision correction surgery, and AtheroGenics, Inc., a
biopharmaceutical company focused on research and development of genes that
regulate atherosclerosis and cancer. He is also a director of privately-held
ArgoMed, Inc., WebEBM Inc. and Elitra Pharmaceuticals. Mr. Pappas received a
B.S. in Biology from Ohio State University and an M.B.A. in Finance from Xavier
University.

DIRECTORS CONTINUING IN OFFICE UNTIL THE 2002 ANNUAL MEETING OF STOCKHOLDERS

STANLEY T. CROOKE, M.D., PH.D.

    Stanley T. Crooke, M.D., Ph.D., 55, has served as a director of the Company
since March 1999. He previously served as a director of GeneMedicine, a
biotechnology company that merged with Valentis in March 1999, from March 1992
to March 1996, and as Chairman of the Board from March 1996 to March 1999.
Dr. Crooke has been Chief Executive Officer and a director of Isis
Pharmaceuticals, Inc., a biotechnology company, since he co-founded Isis in
January 1989, and he has served as Chairman of the Board of Isis since
February 1991. Dr. Crooke is a member of the Board of Directors of Idun
Pharmaceuticals, Inc. SYNSORB Biotech, Inc., Axon Instruments, Inc., EPIX
Medical Inc. and Isis Pharmaceuticals, Inc. Dr. Crooke received a Ph.D. in
Pharmacology and an M.D. from Baylor College of Medicine, where he served for a
number of years as Adjunct Professor of Pharmacology. He currently serves as
Adjunct Professor of Pharmacology at the University of California, San Diego.

PATRICK G. ENRIGHT

    Patrick G. Enright, 38, is a partner at Diaz & Altschul Group, LLC, a
privately held merchant bank, and has been a director of the Company since
March 1998. From March 1995 to February 1998, Mr. Enright served in various
executive positions at the Company, including Senior Vice President, Corporate
Development and Chief Financial Officer. From September 1993 to June 1994,
Mr. Enright was Senior Vice President of Finance and Business Development for
Boehringer Mannheim Therapeutics, a pharmaceutical company and a subsidiary of
Corange Ltd. From September 1989 to September 1993, Mr. Enright was employed at
PaineWebber Incorporated, an investment banking firm, where he became a Vice
President in January 1992. Mr. Enright received his M.B.A. from the Wharton
School of Business at the University of Pennsylvania and his B.S. in biological
sciences from Stanford University.

GILLIAN E. FRANCIS, M.B., D.SC. (MED) FRCPATH

    Gillian E. Francis, M.B., D.Sc. (Med), FRCPath, 52, has served as a director
of the Company since September 1999. Dr. Francis is Managing Director of
PolyMASC Pharmaceuticals plc, a wholly-owned

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subsidiary of Valentis ("PolyMASC"). From December 1995 to August 1999,
Dr. Francis was Chief Executive Officer of PolyMASC. Currently Dr. Francis is on
full secondment from Royal Free and University College Medical School (part of
the University of London) to PolyMASC. From 1994 to present, Dr. Francis has
been Head of Department of Molecular Cell Pathology, Royal Free Hospital School
of Medicine and Honorary Consultant, Royal Free Hospital. In December 1995,
Dr. Francis was seconded as CEO, PolyMASC, maintaining post as Head of Molecular
Cell Pathology (without active duties).

BOARD COMMITTEES AND MEETINGS

    The Board of Directors held twelve (12) meetings during the fiscal year
ended June 30, 2000. During the fiscal year, the Board had an Audit Committee
and a Compensation Committee.

    The Audit Committee meets with the Company's independent auditors at least
annually to review the results of the annual audit and discuss the financial
statements; recommends to the Board the independent auditors to be retained; and
receives and considers the accountants' comments as to controls, adequacy of
staff and management performance and procedures in connection with audit and
financial controls. The Audit Committee is composed of three non-employee
directors: Mr. Enright, Mr. McDade and Mr. Pappas. The Audit Committee met three
(3) times during the fiscal year ended June 30, 2000. The Board and the Audit
Committee have adopted an Audit Committee Charter, which is attached hereto as
EXHIBIT A.

    The Compensation Committee makes recommendations concerning salaries and
incentive compensation, awards stock options to employees and consultants under
the Company's stock option plans and otherwise determines compensation levels
and performs such other functions regarding compensation as the Board may
delegate. The Compensation Committee is composed of three non-employee
directors: Drs. Crooke and Kucherlapati and Mr. Pappas. The Compensation
Committee met four (4) times during the last fiscal year.

    During the fiscal year ended June 30, 2000, each Board member attended 75%
or more of the aggregate of the meetings of the Board and of the committees on
which he or she served, held during the period for which he or she was a
director or committee member, respectively.

COMPENSATION OF DIRECTORS

    Each non-employee director of the Company receives a quarterly retainer of
$3,000 and a per meeting fee of $1,000. The members of the Board of Directors
are also eligible for reimbursement for their expenses incurred in connection
with attendance at Board meetings in accordance with Company policy.

    Under the Directors' Plan, on the date of the annual stockholders' meeting
of each year, each member of the Company's Board of Directors who is not an
employee of the Company will automatically be granted under the Company's 1998
Non-Employee Director, without further action by the Company, the Board of
Directors or the stockholders of the Company, an option to purchase 10,000
shares of Common Stock of the Company. In addition, each new non-employee
director will receive a one time grant to purchase 25,000 shares of Common Stock
on the date of the annual stockholders' meeting at which such new director is
elected to the Board of Directors. The exercise price of the options granted to
the non-employee directors is 100% of the fair market value of the Common Stock
subject to the option on the date of the option grant.

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

    During the year ended June 30, 2000, none of the Company's executive
officers served on the board of any entities whose directors or officers serve
on the Company's Compensation Committee. No

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current or former executive officer or employee of the Company serves on the
Compensation Committee.

                                   PROPOSAL 2
                            APPROVAL OF AMENDMENT TO
                         THE 1997 EQUITY INCENTIVE PLAN

    In July 1997, the Board of Directors adopted, and the stockholders
subsequently approved, the Company's 1997 Equity Incentive Plan (the "Incentive
Plan"). As of June 30, 2000, there were 3,100,000 shares reserved for issuance
under the Incentive Plan.

    As of September 30, 2000, options (net of cancelled, repurchased or expired
options) covering an aggregate of 3,096,090 shares had been granted under the
Incentive Plan, and 3,910 shares (plus any shares that might in the future be
returned to the Incentive Plan as a result of cancellations, repurchases or
expiration of options) remained available for future grant under the Incentive
Plan. In September 2000, the Board approved an amendment to the Incentive Plan,
subject to stockholder approval, to increase the number of shares authorized for
issuance under the Incentive Plan from 3,100,000 shares to 5,100,000 shares.
This amendment is intended to afford the Company greater flexibility in
providing employees with stock incentives and ensures that the Company can
continue to provide such incentives at levels determined appropriate by the
Board.

    Stockholders are requested in this Proposal 2 to approve the Incentive Plan,
as amended. The affirmative vote of the holders of a majority of the shares
present in person or represented by proxy and entitled to vote at the meeting
will be required to approve the Incentive Plan, as amended. Abstentions will be
counted toward the tabulation of votes cast on proposals presented to the
stockholders and will have the same effect as negative votes. Broker non-votes
are counted towards a quorum, but are not counted for any purpose in determining
whether this matter has been approved.

                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 2.

    The essential features of the Incentive Plan are described below.

GENERAL

    The Incentive Plan provides for the grant or issuance of incentive stock
options, nonstatutory stock options, restricted stock purchase awards and stock
bonuses to employees, directors and consultants (collectively, "Stock Awards").
Incentive stock options granted under the Incentive Plan are intended to qualify
as "incentive stock options" within the meaning of Section 422 of the Internal
Revenue Code of 1986, as amended (the "Code"). Nonstatutory stock options
granted under the Incentive Plan are not intended to qualify as incentive stock
options under the Code. See "Federal Income Tax Information" for a discussion of
the tax treatment of the various Stock Awards included in the Incentive Plan.

PURPOSE

    The Incentive Plan provides a means by which selected employees, directors
and consultants to the Company, and its affiliates, may be given an opportunity
to purchase Common Stock of the Company. The Company, by means of the Incentive
Plan, seeks to retain the services of persons who are now employees, directors
or consultants to the Company or its affiliates, to secure and retain the
services of new employees, directors and consultants, and to provide incentives
for such persons to exert maximum efforts for the success of the Company and its
affiliates.

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ADMINISTRATION

    The Incentive Plan is administered by the Board of Directors of the Company.
The Board has the power to construe and interpret the Incentive Plan and,
subject to the provisions of the Incentive Plan, to determine the persons to
whom and the dates on which Stock Awards will be granted; whether a Stock Award
will be an incentive stock option, a nonstatutory stock option, a stock bonus, a
right to purchase restricted stock, or a combination of the foregoing; the
provisions of each Stock Award granted (which need not be identical), including
the time or times when a person shall be permitted to receive stock pursuant to
a Stock Award; and the number of shares with respect to which a Stock Award
shall be granted to each such person. The Board of Directors is authorized to
delegate administration of the Incentive Plan to a committee composed of than
one or more members of the Board. In the discretion of the Board, a committee
may consist solely of two or more members who are "non-employee directors"
within the meaning of Rule 16b-3 promulgated under the Securities Exchange Act
of 1934, as amended (the "Exchange Act"), or solely of two or more members who
are "outside directors" within the meaning of Section 162(m) of the Code.

SHARES SUBJECT TO THE INCENTIVE PLAN

    The Common Stock that may be sold pursuant to Stock Awards under the
Incentive Plan shall not exceed in the aggregate 5,100,000 (assuming approval of
Proposal 2) shares of the Company's Common Stock. If any Stock Award expires or
terminates, in whole or in part, without having been exercised in full (or
vested in the case of restricted stock), the Common Stock not purchased under
such Stock Award will revert to and again become available for issuance under
the Incentive Plan. The Common Stock subject to the Incentive Plan may be
unissued shares or reacquired shares, bought on the market or otherwise.

ELIGIBILITY

    Incentive stock options may be granted only to employees. Nonstatutory stock
options, restricted stock purchase awards and stock bonuses may be granted only
to employees, directors or consultants.

    No person is eligible for the grant of an incentive stock option if, at the
time of grant, such person owns stock possessing more than 10% of the total
combined voting power of all classes of stock of the Company unless the exercise
price of such option is at least 110% of the fair market value of Common Stock
subject to the option at the date of grant and the option is not exercisable
after the expiration of five years from the date of grant. For incentive stock
options granted under the Incentive Plan, the aggregate fair market value,
determined at the time of grant, of the shares of Common Stock with respect to
which such options are exercisable for the first time by an optionee during any
calendar year (under all such plans of the Company and its affiliates) may not
exceed $100,000.

    The Incentive Plan has a per-employee, per-calendar year period limitation
on the number of shares of Common Stock that may be made subject to options
equal to 500,000 shares of Common Stock. The purpose of this limitation is
generally to permit the Company to continue to be able to deduct for tax
purposes the compensation attributable to the exercise of options under the
Incentive Plan. To date, the Company has not granted to any individual in any
calendar year options to purchase a number of shares equal to or in excess of
the limitation.

TERM AND TERMINATION

    The following is a description of the permissible terms of options under the
Incentive Plan. Individual option grants may be more restrictive.

    No option is exercisable after the expiration of 10 years from the date it
was granted.

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    In the event an optionholder's continuous service with Company is
terminated, for any reason other than death or disability, the optionholder may
exercise his or her option (to the extent that the optionholder was entitled to
exercise it at the time of termination), but only within the period ending on
the earlier of (i) three months following such termination (or such longer or
shorter period as specified in the option agreement) or (ii) the expiration of
the term of the option as set forth in the option agreement. In addition, with
the consent of the optionholder, the Board at any time may extend the
post-termination exercise period and provide for continued vesting.

    In the event an optionholder's continuous service with the Company
terminates as a result of the optionholder's death or disability, the
optionholder (or such optionholder's estate, heirs or beneficiaries) may
exercise his or her option, but only within the period ending on the earlier of
(i) twelve months following such termination (or such longer or shorter period
as specified in the option agreement) or (ii) the expiration of the term of the
option as set forth in the option agreement.

    An optionholder's option agreement may also provide that if the exercise of
the option following the termination of the optionholder's continuous service
with the Company would result in liability under Section 16(b) of the Exchange
Act, then the option shall terminate on the earlier of (i) the expiration of the
term of the option set forth in the option agreement, or (ii) the tenth day
after the last date on which such exercise would result in such liability under
Section 16(b) of the Exchange Act. Finally, an optionholder's option agreement
may also provide that if the exercise of the option following the termination of
the optionholder's continuous service with the Company would be prohibited at
any time solely because the issuance of shares would violate the registration
requirements under the Securities Act of 1933, as amended, then the option shall
terminate on the earlier of (i) the expiration of the term of the option as set
forth in the immediately preceding paragraph, or (ii) the expiration of a period
of three months after the termination of the optionholder's continuous service
with the Company during which the exercise of the option would not be in
violation of such registration requirements.

    In the event a restricted stock recipient's continuous service with the
Company terminates, the Company may repurchase or otherwise reacquire any or all
of the shares of Common Stock held by that person which have not vested as of
the date of termination under the terms of the restricted stock purchase
agreement between the Company and such person.

EXERCISE/PURCHASE PRICE

    The exercise price of each incentive stock option will not be less than 100%
of the fair market value of the Company's Common Stock on the date of grant, and
in some cases may be higher (see "Eligibility"). The exercise price of each
nonstatutory stock option will not be less than 85% of the fair market value of
the Company's Common Stock on the date of grant. However, if options were
granted with exercise prices below fair market value, deductions for
compensation attributable to the exercise of such options could be limited by
Section 162(m). See "Federal Income Tax Information." At October 19, 2000, the
closing price of the Company's Common Stock as reported on the Nasdaq National
Market was $7.50 per share.

    The purchase price of restricted stock will not be less than 85% of the fair
market value of the Company's Common Stock on the date such Stock Award is made.
Stock bonuses may be awarded in consideration for past services actually
rendered to the Company or for its benefit.

    In the event of a decline in the value of the Company's Common Stock, the
Board has the authority to offer employees the opportunity to replace
outstanding higher priced options, whether incentive or nonstatutory, with new
lower priced options. The Company has entered into an agreement with certain of
its investors that will prevent the Company from repricing options without
consent from stockholders. To the extent required by Section 162(m), an option
repriced under the Incentive Plan is

                                       8
<PAGE>
deemed to be canceled and a new option granted. Both the options deemed to be
canceled and the new options deemed to be granted will be counted against the
500,000 share limitation.

CONSIDERATION

    The purchase price of Common Stock acquired pursuant to a Stock Award is
paid either in cash at the time of exercise or purchase, or (if determined by
the Board at the time of grant for an option) by deferred payment or in any
other form of legal consideration that may be acceptable to the Board.
Additionally, in the case of an option, and in the discretion of the Board at
the time of the grant, by delivery to the Company of other Common Stock of the
Company. In the case of any deferred payment arrangement, interest will be
payable at least annually and will be charged at the minimum rate of interest
necessary to avoid the imputation of interest.

TRANSFERABILITY

    An incentive stock option shall not be transferable except by will or by the
laws of descent and distribution, and shall be exercisable during the lifetime
of the person to whom the incentive stock option is granted only by such person.
A nonstatutory stock option shall be transferable only to the extent
specifically provided for in the option agreement evidencing the nonstatutory
stock option, provided that if the nonstatutory stock option agreement does not
provide for transferability, then the option is not transferable except by will
or by the laws of descent and distribution or pursuant to a domestic relations
order. A stock bonus or restricted stock purchase award shall not be
transferable except by will or by the laws of descent and distribution or
pursuant to a domestic relations order. A Stock Award holder may designate a
beneficiary who may exercise his or her Stock Award after death.

VESTING

    The total number of shares of Common Stock subject to an option may, but
need not, be allotted in periodic installments. The option agreement may provide
that from time to time during each of such installment periods, the option may
become exercisable ("vest") with respect to some or all of the shares allotted
to that period, and may be exercised with respect to some or all of the shares
allotted to such period and/or any prior period as to which the option became
vested but was not fully exercised. The option agreement may also provide that
an optionholder may exercise an option prior to full vesting, provided that the
Company may have a repurchase right with respect to any unvested shares.

    Restricted stock purchase awards and stock bonuses granted under the
Incentive Plan may be granted pursuant to a repurchase option in favor of the
Company in accordance with a vesting schedule determined by the Board.

ADJUSTMENTS UPON CHANGES IN COMMON STOCK

    If any change is made in the Common Stock subject to the Incentive Plan, or
subject to any Stock Award, without receipt of consideration by the Company
(through merger, consolidation, reorganization, recapitalization, stock
dividend, dividend in property other than cash, stock split, liquidating
dividend, combination of shares, exchange of shares, change in corporate
structure or otherwise), the class(es) and maximum number of shares subject to
the Incentive Plan, the maximum annual Stock Award applicable under the
Incentive Plan and the class(es) and number of shares and price per share of
Common Stock subject to outstanding Stock Awards will be appropriately adjusted.

                                       9
<PAGE>
    Upon a change in control of the Company, the vesting of options held by
executive officers will accelerate by the greater of 12 months or the number of
months of the executive officer's employment, unless the Board finds that it is
in the best interest of the Company's stockholders and the optionees to provide
otherwise. If such a finding is made, the options shall either remain
outstanding or be assumed by the acquiror (with the optionee being entitled to
receive the same consideration as was received by the Company's stockholders in
the change of control transaction) or the Board and/or the acquiror shall adopt
a replacement benefit which shall (at a minimum) provide value to the executive
officer on the vesting dates of the non-accelerated options substantially equal
to the value the executive officer would have received if the shares had
participated in all steps of the transaction. With respect to optionees who are
not executive officers, upon a change in control any options shall remain
outstanding, be assumed by the acquiror or be substituted with similar options.
In the event the acquiror refuses to assume, substitute or continue any options,
then such options shall be terminated if not exercised prior to the change of
control. For purposes of this Plan, "Change in Control" means: any consolidation
or merger of the Company with or into any other entity or person, or any other
corporate reorganization, in which the Company is not the continuing or
surviving entity, or any transaction or series of related transactions by the
Company in which in excess of 50% of the Company's voting power is transferred,
or any sale, lease, license or other disposition of all or substantially all of
the assets of the Company.

AMENDMENT OF THE INCENTIVE PLAN

    The Board at any time, and from time to time, may amend the Incentive Plan.
However, no amendment shall be effective unless approved by the stockholders of
the Company within 12 months before or after the adoption of the amendment,
where such amendment requires stockholder approval in order for the Incentive
Plan to satisfy the requirements of Section 422 of the Code, Rule 16b-3 of the
Exchange Act or any Nasdaq or securities exchange listing requirement. The Board
may in its sole discretion submit any other amendment to the Incentive Plan for
stockholder approval.

TERMINATION OR SUSPENSION OF THE INCENTIVE PLAN

    The Board may suspend or terminate the Incentive Plan at any time. Unless
sooner terminated, the Incentive Plan shall terminate on July 24, 2007. No Stock
Awards may be granted under the Incentive Plan while the Incentive Plan is
suspended or after it is terminated.

FEDERAL INCOME TAX INFORMATION

    INCENTIVE STOCK OPTIONS.  Incentive stock options under the Incentive Plan
are intended to be eligible for the favorable federal income tax treatment
accorded "incentive stock options" under the Code.

    There generally are no federal income tax consequences to the optionholder
or the Company by reason of the grant or exercise of an incentive stock option.
However, the exercise of an incentive stock option is an alternative minimum tax
adjustment item and may increase the optionholder's alternative minimum tax
liability, if any.

    If an optionholder holds Common Stock acquired through exercise of an
incentive stock option for at least two years from the date on which the option
is granted and at least one year from the date on which the shares are
transferred to the optionholder upon exercise of the option, any gain or loss on
a disposition of such Common Stock will be capital gain or loss. Generally, if
the optionholder disposes of the Common Stock before the expiration of either of
these holding periods (a "disqualifying disposition"), at the time of
disposition, the optionholder will realize taxable ordinary income equal to the
lesser of (a) the excess of the Common Stock's fair market value on the date of
exercise over the exercise price, or (b) the optionholder's actual gain, if any,
on the purchase and sale. The optionholder's additional gain, or any loss, upon
the disqualifying disposition will be a capital gain or

                                       10
<PAGE>
loss, which will be long-term or short-term depending on how long the Common
Stock was held. Long-term capital gains (i.e., gains on capital assets held for
more than one year) currently are generally subject to lower tax rates than
ordinary income. Slightly different rules may apply to optionholders who acquire
Common Stock subject to certain repurchase options or who are subject to
Section 16(b) of the Exchange Act.

    To the extent the optionholder recognizes ordinary income by reason of a
disqualifying disposition, the Company will generally be entitled (subject to
the requirement of reasonableness, the provisions of Section 162(m) of the Code
and the satisfaction of a tax reporting obligation) to a corresponding business
expense deduction in the tax year in which the disqualifying disposition occurs.

    NONSTATUTORY STOCK OPTIONS.  Nonstatutory stock options granted under the
Incentive Plan generally have the following federal income tax consequences:

    There are no tax consequences to the optionholder or the Company by reason
of the grant of a nonstatutory stock option. Upon exercise of a nonstatutory
stock option, the optionholder normally will recognize taxable ordinary income
equal to the excess of the Common Stock's fair market value on the date of
exercise over the option exercise price. With respect to employees, the Company
is generally required to withhold from regular wages or supplemental wage
payments an amount based on the ordinary income recognized. Generally, the
Company will be entitled (subject to the requirement of reasonableness, the
provisions of Section 162(m) of the Code and the satisfaction of a tax reporting
obligation) to a business expense deduction equal to the taxable ordinary income
realized by the optionholder. Upon disposition of the Common Stock, the
optionholder will recognize a capital gain or loss equal to the difference
between the selling price and the sum of the amount paid for such Common Stock
plus any amount recognized as ordinary income upon exercise of the option. Such
gain or loss will be long-term or short-term depending on how long the Common
Stock was held. Slightly different rules may apply to optionholders who acquire
Common Stock subject to certain repurchase options or who are subject to
Section 16(b) of the Exchange Act.

    RESTRICTED STOCK PURCHASE AWARDS.  Restricted stock purchase awards and
stock bonuses granted under the Incentive Plan generally have the following
federal income tax consequences:

    Upon acquisition of the Common Stock, the recipient normally will recognize
taxable ordinary income equal to the excess of the Common Stock's fair market
value over the purchase price, if any. However, to the extent the Common Stock
is subject to certain types of vesting restrictions, the taxable event will be
delayed until the vesting restrictions lapse unless the recipient elects to be
taxed on receipt of the Common Stock. With respect to employees, the Company is
generally required to withhold from regular wages or supplemental wage payments
an amount based on the ordinary income recognized. Generally, the Company will
be entitled (subject to the requirement of reasonableness, the provisions of
Section 162(m) of the Code and the satisfaction of a tax reporting obligation)
to a business expense deduction equal to the taxable ordinary income realized by
the recipient. Upon disposition of the Common Stock, the recipient will
recognize a capital gain or loss equal to the difference between the selling
price and the sum of the amount paid for such Common Stock, if any, plus any
amount recognized as ordinary income upon acquisition (or vesting) of the Common
Stock. Such gain or loss will be long-term or short-term depending on how long
the Common Stock was held. Slightly different rules may apply to recipients who
are subject to Section 16(b) of the Exchange Act.

    POTENTIAL LIMITATION ON COMPANY DEDUCTIONS.  Section 162(m) of the Code
denies a deduction to any publicly held corporation for compensation paid to
certain "covered employees" in a taxable year to the extent that compensation
exceeds $1 million for a covered employee. It is possible that compensation
attributable to Stock Awards granted in the future under the Incentive Plan,
when combined with all other types of compensation received by a covered
employee from the Company, may cause this limitation to be exceeded in any
particular year.

                                       11
<PAGE>
    Certain kinds of compensation, including qualified "performance-based
compensation," are disregarded for purposes of the deduction limitation. In
accordance with Treasury regulations issued under Section 162(m) of the Code,
compensation attributable to stock options will qualify as performance-based
compensation, provided that: (i) the stock award plan contains a per-employee
limitation on the number of shares for which stock options and stock
appreciation rights may be granted during a specified period; (ii) the
per-employee limitation is approved by the stockholders; (iii) the award is
granted by a compensation committee comprised solely of "outside directors"; and
(iv) the exercise price of the award is no less than the fair market value of
the stock on the date of grant. Stock bonuses qualify as performance-based
compensation under the Treasury regulations only if: (i) the award is granted by
a compensation committee comprised solely of "outside directors"; (ii) the award
is earned (typically through vesting) only upon the achievement of an objective
performance goal established in writing by the compensation committee while the
outcome is substantially uncertain; (iii) the compensation committee certifies
in writing prior to the earning of the awards that the performance goal has been
satisfied; and (iv) prior to the earning of the award, stockholders have
approved the material terms of the award (including the class of employees
eligible for such award, the business criteria on which the performance goal is
based, and the maximum amount (or formula used to calculate the amount) payable
upon attainment of the performance goal.

                                   PROPOSAL 3
                            APPROVAL OF AMENDMENT TO
                 1998 NON-EMPLOYEE DIRECTORS' STOCK OPTION PLAN

    In September 1998, the Board of Directors adopted, and the stockholders
subsequently approved, the Company's 1998 Non-Employee Directors' Stock Option
Plan (the "Directors' Plan"). There were originally 200,000 shares reserved for
issuance under the Directors' Plan.

    As of September 30, 2000, options (net of cancelled, repurchased or expired
options) covering an aggregate of 190,000 shares had been granted under the
Directors' Plan and 10,000 shares (plus any shares that might in the future be
returned to the Directors' Plan as a result of cancellations, repurchases or
expiration of options) remained available for future grant under the Directors'
Plan. In September 2000, the Board approved an amendment to the Directors' Plan,
subject to stockholder approval, to increase the number of shares authorized for
issuance under the Directors' Plan from 200,000 shares to 400,000 shares. This
amendment is intended to afford the Company greater flexibility in providing
non-employee directors with stock incentives and ensures that the Company can
continue to provide such incentives at levels determined appropriate by the
Board.

    Stockholders are requested in this Proposal 3 to approve the Directors'
Plan, as amended. The affirmative vote of the holders of a majority of the
shares present in person or represented by proxy and entitled to vote at the
meeting will be required to approve the Directors' Plan, as amended. Abstentions
will be counted toward the tabulation of votes cast on proposals presented to
the stockholders and will have the same effect as negative votes. Broker
non-votes are counted towards a quorum, but are not counted for any purpose in
determining whether this matter has been approved.

                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 3.

    The essential features of the Directors' Plan are described below.

GENERAL

    The purpose of the Directors' Plan is to attract and retain the services of
persons capable of serving as Non-Employee Directors (as defined below) on the
Board and to provide incentives for such persons to exert maximum efforts to
promote the success of the Company. Options granted under the

                                       12
<PAGE>
Directors' Plan are not intended to qualify as incentive stock options, as
defined under Section 422 of the Code. See "Tax Information" for a discussion of
the tax treatment of non-qualified stock options.

ADMINISTRATION

    The Directors' Plan is administered by the Board. The Board has the final
power to construe and interpret the Directors' Plan and options granted under
it, and to establish, amend and revoke rules and regulations for its
administration.

ELIGIBILITY

    The Directors' Plan provides that options may be granted only to
Non-Employee Directors of the Company. A "Non-Employee Director" is defined in
the Directors' Plan as a director of the Company who is not otherwise an
employee to the Company or any affiliate. Assuming the approval of Proposal 1,
after the Annual Meeting, six (6) of the Company's directors would be eligible
to participate in the Directors' Plan.

    Option grants under the Directors' Plan are non-discretionary. Pursuant to
the terms of the Directors' Plan, (i) each Non-Employee Director, other than a
Non-Employee Director who currently serves on the Board, automatically shall be
granted, upon his or her initial election or appointment as a Non-Employee
Director, an option to purchase 25,000 shares of Common Stock (an "Initial
Grant"); and (ii) commencing with the annual meeting of stockholders in 1998,
each person who is serving as a Non-Employee Director on the day following each
annual meeting of stockholders automatically shall be granted an option to
purchase 10,000 shares of Common Stock (an "Annual Grant").

TERMS OF OPTIONS

    Each option under the Directors' Plan is subject to the following terms and
conditions:

    OPTION EXERCISE; VESTING.  Initial Grants to new Non-Employee Directors
under the Directors' Plan shall vest as to 25% of the shares on the first
anniversary of the date of grant and in equal monthly installments over the next
36 months for a total vesting period of four years. Annual Grants to continuing
Non-Employee Directors shall vest in equal monthly installments over a period of
one year from the date of grant. Such vesting is conditioned upon continued
service as a director, employee or consultant of the Company. An option granted
under the Directors' Plan may be exercised by giving written notice of exercise
to the Company, specifying the number of full shares of Common Stock to be
purchased and tendering payment of the purchase price to the Company.

    EXERCISE PRICE; PAYMENT.  The exercise price of options granted under the
Directors' Plan shall be equal to 100% of the fair market value of the Common
Stock subject to such options on the date of grant. The exercise price of
options granted under the Directors' Plan may be paid, to the extent provided in
the option agreement between the Company and the optionholder, in any
combination of the following: (i) cash or check; or (ii) delivery of other
Common Stock of the Company that has been held for the period of time required
to avoid a charge to the Company's earnings (such shares shall be valued at
their fair market value on the date preceding the date of exercise);
(iii) deferred payment; or (iv) any other form of legal consideration that may
be acceptable to the Board and provided in the option agreement.

    TRANSFERABILITY; TERM.  Under the Directors' Plan, an option may not be
transferred by the optionholder, except by will or by the laws of descent and
distribution. During the lifetime of an optionholder, an option may be exercised
only by the optionholder. Notwithstanding the foregoing, the optionholder may,
by delivering written notice to the Company, in a form satisfactory to the
Company, designate a third party who, in the event of the death of the
optionholder, shall thereafter be entitled to exercise the Option. No option
granted under the Directors' Plan is exercisable by any person after the
expiration of ten years from the date the option is granted. An optionholder
whose service

                                       13
<PAGE>
relationship with the Company or any affiliate (whether as a Non-Employee
Director of the Company or subsequently as an employee, director or consultant
of either the Company or an affiliate) ceases for any reason may exercise vested
options for the term provided in the option agreement (12 months generally,
18 months in the event of death).

    OTHER PROVISIONS.  The option agreement may contain such other terms,
provisions and conditions not inconsistent with the Directors' Plan as may be
determined by the Board.

ADJUSTMENT PROVISIONS

    If there is any change in the stock subject to the Directors' Plan or
subject to any option granted under the Directors' Plan (through merger,
consolidation, reorganization recapitalization, stock dividend, dividend in
property other than cash, stock split, liquidating, dividend, combination of
shares, exchange of shares, change in corporate structure or otherwise), the
Directors' Plan and options outstanding thereunder will be appropriately
adjusted as to the class and the maximum number of shares subject to such plan
and the class, number of shares and price per share of stock subject to such
outstanding options.

    The Directors' Plan provides that, in the event of (1) a consolidation or
merger of the Company with or into any other entity or person; (2) any other
corporate reorganization in which the Company is not the continuing or surviving
entity; or (3) any transaction or series of related transactions by the Company
in which in excess of 50% of the Company's voting power is transferred; or
(4) any sale, lease license or other disposition of all or substantially all of
the assets of the Company, then any surviving corporation or acquiring
corporation shall assume any options outstanding under the Directors Plan or
substitute similar options for any options outstanding. If any surviving or
acquiring corporation refuses to assume such options or substitute similar
options, then the vesting of such options outstanding under the Directors' Plan
that are held by optionholders whose service with the Company continues shall be
accelerated in full and the options terminated if not exercised at or prior to
such event.

DURATION, AMENDMENT AND TERMINATION

    The Board may amend, suspend or terminate the Directors' Plan at any time or
from time to time. No amendment will be effective unless approved by the
stockholders of the Company within twelve months before or after its adoption by
the Board if the amendment would increase the number of shares reserved for
options under the Directors' Plan.

TAX INFORMATION

    Stock options granted under the Directors' Plan are subject to federal
income tax treatment pursuant to rules governing options that are not incentive
stock options.

    The following is only a summary of the effect of federal income taxation
upon the optionholder and the Company with respect to the grant and exercise of
options under the Directors' Plan, does not purport to be complete, and does not
discuss the income tax laws of any state or foreign country in which an
optionholder may reside.

    Options granted under the Directors' Plan are nonstatutory options. There
are no tax consequences to the optionholder or the Company by reason of the
grant of a nonstatutory stock option. Upon exercise of a nonstatutory stock
option, the optionholder normally will recognize taxable ordinary income equal
to the excess of the stock's fair market value on the date of exercise over the
option exercise price. Subject to the requirement of reasonableness, the Company
will be entitled to a business expense deduction equal to the taxable ordinary
income realized by the optionee. Upon disposition of the stock, the optionholder
will recognize a capital gain or loss equal to the difference between the
selling price and the sum of the amount paid for such stock plus any amount
recognized

                                       14
<PAGE>
as ordinary income upon exercise of such option. Such gain or loss will be long
or short-term depending on whether the stock was held for more than one year.

    The foregoing discussion is intended to be a general summary only of the
federal income tax aspects of options granted under the Directors' Plan; tax
consequences may vary depending on the particular circumstances at hand. In
addition, administrative and judicial interpretations of the application of the
federal income tax laws are subject to change. Furthermore, no information is
given with respect to state or local taxes that may be applicable. Participants
in the Directors' Plan who are residents of a country other than the United
States may be subject to taxation in accordance with the tax laws of that
particular country in addition to or in lieu of United States federal income
taxes.

                                   PROPOSAL 4
             APPROVAL OF AMENDMENT TO EMPLOYEE STOCK PURCHASE PLAN

    In July 1997, the Board of Directors adopted the Company's Employee Stock
Purchase Plan (the "Purchase Plan"), which the stockholders approved in
September 1997. As of June 30, 2000, there were 200,000 shares reserved for
issuance under the Incentive Plan.

    As of September 30, 2000, 22,024 shares of Common Stock were available for
issuance under the Purchase Plan. In September 2000, the Board approved an
amendment to the Purchase Plan, subject to stockholder approval, to increase the
number of shares authorized for issuance under the Purchase Plan by 200,000
shares.

    Stockholders are requested in this Proposal 4 to approve the Purchase Plan,
as amended. The affirmative vote of the holders of a majority of the shares
present in person or represented by proxy and entitled to vote at the meeting
will be required to approve the Purchase Plan, as amended. Abstentions will be
counted toward the tabulation of votes cast on proposals presented to the
stockholders and will have the same effect as negative votes. Broker non-votes
are counted towards a quorum, but are not counted for any purpose in determining
whether this matter has been approved.

                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 4.

    The essential features of the Purchase Plan are described below.

GENERAL

    The Purchase Plan enables eligible employees of the Company to purchase,
through payroll deductions, shares of Common Stock at a discount from the market
price of the stock at the time of purchase. The Purchase Plan is intended to
qualify as an employee stock purchase plan within the meaning of Section 423 of
the Code.

ADMINISTRATION

    The Purchase Plan is administered by the Board of Directors of the Company.
The Board has the authority to interpret the Purchase Plan and to determine
eligibility and the terms of other benefits under the Plan. With respect to each
Offering, the Board has the authority to specify:

    (i) a date ("Offering Date") on which rights to purchase Common Stock will
        be granted to eligible employees;

    (ii) the period of time (an "Offering Period"), which cannot exceed
         27 months, during which the Offering will be in effect and the dates
         ("Purchase Dates") on which shares of stock will be purchased pursuant
         to rights granted under the Offering; and

   (iii) the terms under which employees may contribute money to purchase stock
         in the Offering.

                                       15
<PAGE>
SHARES SUBJECT TO THE PURCHASE PLAN

    Assuming the approval of Proposal 4, 400,000 shares of Common Stock have
been reserved for issuance under the Purchase Plan. The stock subject to the
Purchase Plan may be unissued shares or reacquired shares, purchased on the open
market or otherwise. To the extent a right under the Purchase Plan terminates
for any reason, any shares not purchased under such right shall again become
available for issuance.

ELIGIBILITY

    Employees are eligible to participate if they have been continuously
employed by the Company (or a U.S.-incorporated subsidiary or parent of the
Company) for at least ten (10) days on the Offering Date (defined below) and are
employed at least 20 hours per week and five months per year. Neither
consultants and advisors who are not also employees, nor individuals who own (or
are deemed to own) in the aggregate five percent (5%) or more of the combined
voting power of the Common Stock, are entitled to participate in the Purchase
Plan. Employees who participate in an offering can have up to 15% of their
earnings withheld pursuant to the Purchase Plan and applied, on specified dates
determined by the Board of Directors, to the purchase of shares of Common Stock.

TERMS

    PARTICIPATION IN OFFERINGS.  Under the Purchase Plan, rights to purchase
Common Stock are granted to eligible employees pursuant to an offering
("offering") established from time to time by the Board of Directors of the
Company.

    Under the terms of the Purchase Plan, the first offering began on the
effective date of the initial public offering of the Company's common stock and
ended on August 15, 1999. A new two-year Offering will commence on August 16,
every other year, beginning with calendar year 1999. If the Offering Date does
not fall on a day during which the Common Stock is actively traded, then the
Offering Date shall be the next succeeding day during which the Common Stock is
actively traded. Purchase Dates fall on each February 15, and August 15. If a
Purchase Date does not fall on a day during which the Common Stock is actively
traded, then the Purchase Date shall be the next succeeding day during which the
Common Stock is actively traded.

    If the fair market value of the Common Stock on any Purchase Date under an
Offering is less than the fair market value on the Offering Date, the Offering
will terminate and be replaced by a new Offering beginning the trading day after
such Purchase Date and ending two years from the beginning of the new offering
period. For example, if the fair market value of Common Stock on August 15, 2001
is lower than the then-current offering price, the current Offering will
terminate and be replaced by a new Offering beginning August 16, 2001 (or the
next trading day after the August 15th Purchase Date and ending on August 15,
2004.

    PRICE AND PAYMENT.  Employees electing to participate in the Purchase Plan
will authorize the Company to automatically deduct after-tax dollars from each
payment until the employee instructs the Company to stop the deductions or until
the employee's employment is terminated. On each designated Purchase Date, the
Company will use the employee's deductions to purchase Common Stock for the
employee at the price equal to the lower of (i) 85% of the fair market value of
the stock on the Offering Date or such other date on which the employee is first
eligible to participate in the Offering and (ii) 85% of the fair market value of
the stock on the Purchase Date.

    TERMINATION.  Employees may end their participation in the offering at any
time during the offering period, and participation ends automatically on
termination of employment with the Company. Upon such termination of the
employee's participation in the Purchase Plan, such employee's payroll
deductions not already used to purchase stock under the Purchase Plan will be
returned to the employee.

                                       16
<PAGE>
DURATION, AMENDMENT AND TERMINATION

    The Company may amend the Purchase Plan at any time. However, certain
changes, such as an amendment increasing the number of shares authorized under
the Purchase Plan, require shareholder approval.

    In the event of certain changes of control, the Company and the Board of
Directors has discretion to provide that each right to purchase Common Stock
will be assumed or an equivalent right substituted by the successor corporation,
or the Board may shorten the Offering Period and provide for all sums collected
by payroll deductions to be applied to purchase stock immediately prior to the
change in control. The Purchase Plan will terminate at the Board's discretion.

                                   PROPOSAL 5
               RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS

    The Board of Directors has selected Ernst & Young LLP as the Company's
independent auditors for the fiscal year ending June 30, 2001 and has further
directed that management submit the selection of independent auditors for
ratification by the stockholders at the Annual Meeting. Ernst & Young LLP has
audited the Company's financial statements since 1994. Representatives of
Ernst & Young LLP are expected to be present at the Annual Meeting, will have an
opportunity to make a statement if they so desire and will be available to
respond to appropriate questions.

    Stockholder ratification of the selection of Ernst & Young LLP as the
Company's independent auditors is not required by the Company's Bylaws or
otherwise. However, the Board is submitting the selection of Ernst & Young LLP
to the stockholders for ratification as a matter of good corporate practice. If
the stockholders fail to ratify the selection, the Audit Committee and the Board
will reconsider whether or not to retain that firm. Even if the selection is
ratified, the Audit Committee and the Board in their discretion may direct the
appointment of different independent auditors at any time during the year if
they determine that such a change would be in the best interests of the Company
and its stockholders.

    The affirmative vote of the holders of a majority of the shares present in
person or represented by proxy and entitled to vote at the Annual Meeting will
be required to ratify the selection of Ernst & Young LLP. Abstentions will be
counted toward the tabulation of votes cast on proposals presented to the
stockholders and will have the same effect as negative votes. Broker non-votes
are counted towards a quorum, but are not counted for any purpose in determining
whether this matter has been approved.

                       THE BOARD OF DIRECTORS RECOMMENDS
                         A VOTE IN FAVOR OF PROPOSAL 5.

                                       17
<PAGE>
         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

    The following table sets forth certain information regarding the beneficial
ownership of the Company's Common Stock as of October 10, 2000 by: (i) each
director and nominee for director; (ii) each of the executive officers named in
the Summary Compensation Table; (iii) all executive officers and directors of
the Company as a group; and (iv) all those known by the Company to be beneficial
owners of more than five percent of its Common Stock.

                            BENEFICIAL OWNERSHIP(1)

<TABLE>
<CAPTION>
                                                                    BENEFICIAL OWNERSHIP(1)
                                                              -----------------------------------
NAME AND ADDRESS OF BENEFICIAL OWNER                          NUMBER OF SHARES   PERCENT OF TOTAL
------------------------------------                          ----------------   ----------------
<S>                                                           <C>                <C>
Stanley T. Crooke, M.D., Ph.D.(2)...........................        20,416             *
Patrick G. Enright(3).......................................       212,499             *
Gillian E. Francis, M.B., D.Sc. (Med), FRCPath..............       575,014            1.95
Raju Kucherlapati, Ph.D.(4).................................        41,666             *
Mark McDade.................................................             0             *
Benjamin F. McGraw, III, Pharm.D.(5)........................       480,959            1.63
Bert W. O'Malley, M.D.(6)...................................        20,416             *
J. Tyler Martin, Sr., M.D...................................             0             *
Arthur M. Pappas(7).........................................        24,413             *
Alain Rolland, Pharm.D., Ph.D.(8)...........................       120,768             *
Margaret M. Snowden(9)......................................        20,677             *
Bennet L. Weintraub(10).....................................        80,948             *
All executive officers and directors as a group (12
  persons)(11)..............................................     1,597,776            5.43
</TABLE>

------------------------

*   Less than one percent.

(1) This table is based upon information supplied by officers, directors and
    principal stockholders and Schedules 13D and 13G if any filed with the
    Securities and Exchange Commission (the "SEC"). Unless otherwise indicated
    in the footnotes to this table and subject to community property laws where
    applicable, the Company believes that each of the stockholders named in this
    table has sole voting and investment power with respect to the shares
    indicated as beneficially owned. Applicable percentages are based on
    29,409,562 shares outstanding on October 10, 2000, adjusted as required by
    rules promulgated by the SEC.

(2) Includes 20,416 shares Dr. Crooke has the right to acquire pursuant to
    outstanding options exercisable within 60 days.

(3) Includes 2,000 shares held in a trust for the benefit of Mr. Enright's son
    for which Mr. Enright and his spouse serve as co-trustees. Also includes
    100,000 shares Mr. Enright has the right to acquire pursuant to outstanding
    options exercisable within 60 days.

(4) Includes 33,333 shares Dr. Kucherlapati has the right to acquire pursuant to
    outstanding options exercisable within 60 days.

(5) Includes 373,333 shares Dr. McGraw acquired pursuant to the exercise of
    stock options, 4,584 of which will be subject to repurchase by the Company
    within 60 days. Also includes 78,618 shares Dr. McGraw has the right to
    acquire pursuant to outstanding options exercisable within 60 days. Includes
    315,148 shares and 12,112 shares held in an irrevocable trust and in a
    children's trust, respectively for the benefit of Dr. McGraw and his spouse
    and Dr. McGraw's children for which Dr. McGraw and his spouse serve as
    co-trustees. Also includes 278 shares contributed as a matching grant from
    the Company to Dr. McGraw's 401(k) plan.

                                       18
<PAGE>
(6) Includes 20,416 shares Dr. O'Malley has the right to acquire pursuant to
    outstanding options exercisable within 60 days.

(7) Includes 20,416 shares Mr. Pappas has the right to acquire pursuant to
    outstanding options exercisable within 60 days.

(8) Includes 18,202 shares Dr. Rolland acquired pursuant to the exercise of
    stock options. Includes 102,916 shares Dr. Rolland has the right to acquire
    pursuant to outstanding options exercisable within 60 days. Also includes
    278 shares contributed as a matching grant to Dr. Rolland's 401(k) plan.

(9) Includes 12,691 shares Ms. Snowden has the right to acquire pursuant to
    outstanding options exercisable within 60 days. Also includes 278 shares
    contributed as a matching grant from the Company to Ms. Snowden's 401(k)
    plan.

(10) Includes 68,324 shares Mr. Weintraub has the right to acquire pursuant to
    outstanding options exercisable within 60 days. Also includes 278 shares
    contributed as a matching grant from the Company to Mr. Weintraub's 401(k)
    plan.

(11) Includes 457,130 shares subject to options exercisable within 60 days.

                                       19
<PAGE>
            SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

    Section 16(a) of the Securities Exchange Act of 1934 (the "1934 Act")
requires the Company's directors and executive officers, and persons who own
more than ten percent of a registered class of the Company's equity securities,
to file with the SEC initial reports of ownership and reports of changes in
ownership of Common Stock and other equity securities of the Company. Officers,
directors and greater than ten percent stockholders are required by SEC
regulation to furnish the Company with copies of all Section 16(a) forms they
file.

    To the Company's knowledge, based solely on a review of the copies of such
reports furnished to the Company and written representations that no other
reports were required, during the fiscal year ended June 30, 2000, all
Section 16(a) filing requirements applicable to its officers, directors and
greater than ten percent beneficial owners were complied with, except that
Ms. Snowden and Dr. Rolland failed to timely file their initial reports on
Form 3. Ms. Snowden and Dr. Rolland both filed their reports shortly after being
notified of the failure to timely file.

                       EXECUTIVE OFFICERS OF THE COMPANY

    The names of the executive officers of the Company, their ages as of
October 10, 2000 and certain other information about them are set forth below
(unless set forth elsewhere in this Proxy Statement):

<TABLE>
<CAPTION>
             NAME                 AGE                 POSITION             OFFICER SINCE
             ----               --------   ------------------------------  --------------
<S>                             <C>        <C>                             <C>
Benjamin McGraw, III,
  Pharm.D.....................     51      President, Chief Executive      September 1997
                                             Officer and Chairman
Bennet L. Weintraub...........     46      Chief Financial Officer and        May 1998
                                           Vice President, Finance
Alain Rolland, Pharm.D.,
  Ph.D........................     40      Vice President, Research and     January 2000
                                             Development
J. Tyler Martin, Sr., M.D.....     41      Vice President, Clinical          July 2000
                                             Development and Regulatory
                                             Affairs
Margaret M. Snowden...........     41      Vice President, Intellectual      March 2000
                                             Property and Legal Affairs
Gillian E. Francis, M.B.,
  D.Sc. (Med), FRCPath........     52      Managing Director, PolyMASC      August 1999
                                             Pharmaceutical plc
</TABLE>

BENNET L. WEINTRAUB

    Bennet L. Weintraub, has served as Chief Financial Officer and Vice
President Finance of the Company since May 1998. From March 1996 to May 1998,
Mr. Weintraub was Chief Financial Officer and Vice President Finance and
Administration for Technology Modeling Associates, a software company. From
September 1993 to March 1996, he was employed as Director of Finance by Metra
Biosystems, a bone diagnostics company, and from September 1987 to
September 1993, he was Controller at Advanced Polymer Systems, a drug delivery
company. Mr. Weintraub received his M.B.A. from Harvard University Graduate
School of Business and his B.A. from Pomona College, and is a CPA in California.

ALAIN ROLLAND

    Alain Rolland, Pharm.D., Ph.D. joined Valentis as Vice President, Research
and Development and Center Head, The Woodlands, upon completion of the merger
with GeneMedicine, Inc. in March 1999. Dr. Rolland previously had been Vice
President, Research of GeneMedicine since February 1998, Vice

                                       20
<PAGE>
President, Gene Delivery Sciences from November 1996 to February 1998 and
Director, Gene Delivery Sciences from June 1993 to November 1996. Prior to
joining GeneMedicine in 1993, Dr. Rolland worked in drug delivery research at
Ciba-Geigy Pharmaceuticals and more recently was Head of the Formulation
Research Group at the International Centre for Dermatological Research (CIRD
Galderma) in France. Dr. Rolland has received numerous international and
national awards for scholarship. Dr. Rolland holds a Pharm.D. and a Ph.D. degree
in Pharmaceutical Sciences from Rennes University in France.

J. TYLER MARTIN, SR.

    J. Tyler Martin, Sr., M.D. joined Valentis as Vice President, Clinical
Development and Regulatory Affairs in July 2000. From December 1997 to July
2000, Dr. Martin was Executive Director, Clinical Research and Development at
the SyStemix/GTI unit of Novartis, AG. Prior to SyStemix/GTI, Dr. Martin served
as Director, Antiviral Clinical Research at Parke-Davis Inc. from April 1997 to
November 1997 and Associate Director of Clinical Research at Chiron Corp. from
February 1994 to April 1997. Dr. Martin received an M.D. from the University of
Nebraska and a B.S. in Chemistry from the University of Nebraska (Kearney).

MARGARET M. SNOWDEN

    Margaret M. Snowden has served as Vice President, Intellectual Property and
Legal Affairs of the Company since March 2000. Ms. Snowden joined the Company in
April 1996 and served previously as Corporate Counsel, Intellectual Property and
Licensing. From October 1993 to April 1996, Ms. Snowden was Patent Attorney with
SyStemix, Inc., a biotechnology company and a subsidiary of Sandoz, Ltd.
Ms. Snowden received her J.D. from Boalt Hall School of Law at the University of
California, Berkeley, and her B.S. and M.S. in cell and molecular biology from
Florida Institute of Technology.

                                       21
<PAGE>
                       COMPENSATION OF EXECUTIVE OFFICERS
                           SUMMARY COMPENSATION TABLE

    The following table shows for the fiscal years ended June 30, 2000, 1999 and
1998, compensation awarded or paid to, or earned by, the Company's Chief
Executive Officer and its other four most highly compensated executive officers
at June 30, 2000 (the "Named Executive Officers"):

<TABLE>
<CAPTION>
                                                                                           LONG-TERM
                                                           ANNUAL COMPENSATION            COMPENSATION
                                                  -------------------------------------    SECURITIES
                                                                         OTHER ANNUAL      UNDERLYING       ALL OTHER
NAME AND PRINCIPAL POSITION              YEAR      SALARY     BONUS     COMPENSATION(1)   OPTIONS/SARS   COMPENSATION(2)
---------------------------            --------   --------   --------   ---------------   ------------   ---------------
<S>                                    <C>        <C>        <C>        <C>               <C>            <C>
Benjamin F. McGraw III, Pharm.D......    2000     $304,484   $50,000           --           107,500           1,150
  Chairman, Chief Executive Officer      1999      318,425    30,000           --            60,000           1,790
  and President                          1998      275,002        --           --                --             656

Bennet L. Weintraub..................    2000      182,379    20,000                         39,375             470
  Chief Financial Officer and Vice       1999      172,622        --           --                --             613
  President, Finance                     1998       13,077(3)      --          --            80,000              --

Alain Rolland, Pharm.D., Ph.D........    2000      216,633        --           --            69,614             381
  Vice President, Research and           1999       50,372(4)  20,000          --            37,508             991
  Development

Margaret M. Snowden..................    2000      151,013        --           --            46,400             271
  Vice President, Intellectual           1999      125,525        --           --                --             124
  Property and Legal Affairs             1998      115,368        --           --                --             224

Gillian E. Francis, M.B., D.Sc.......    2000      129,828(5)      --          --            70,000          44,388
  (Med) FRCPath Managing Director,
  PolyMASC Pharmaceuticals plc
</TABLE>

--------------------------

(1) As permitted by rules promulgated by the SEC, no amounts are shown where the
    amounts constitute perquisites and do not exceed the higher of 10% of the
    sum of the salary and bonus column and $50,000.

(2) Represents insurance premiums paid by the Company with respect to group life
    insurance for the benefit of the Named Executive Officers.

(3) Represents actual compensation received by Mr. Weintraub during fiscal year
    ended June 30, 1998. Mr. Weintraub joined the Company in May 1998. His
    annualized salary for fiscal year ended June 30, 1998 was $172,622.

(4) Represents actual compensation received by Dr. Rolland during fiscal year
    ended June 30, 1999. Dr. Rolland joined the company in March 1999. His
    annualized salary for fiscal year ended June 30, 1999 was $215,391.

(5) Represents actual compensation received by Dr. Francis during fiscal year
    ended June 30, 2000. Dr. Francis joined the Company in August 1999. Her
    annualized salary for fiscal year ended June 30, 1999 was $152,354. Other
    compensation represents pension benefits, insurance premium, Director's fees
    and an automobile allowance received by Dr. Francis during the fiscal year
    ended June 30, 2000. Dr. Francis' compensation was paid in Great Britain
    Pounds and was converted to U.S. dollars using an average of 1.59 dollars
    for 1.00 British pound.

                                       22
<PAGE>
                       STOCK OPTION GRANTS AND EXERCISES

    The Company grants options to its executive officers under its Incentive
Plan. As of September 30, 2000, options to purchase a total of 3,096,090 shares
were outstanding under the Incentive Plan and options to purchase 3,910 shares
remained available for grant thereunder.

    The following tables show for the fiscal year ended June 30, 2000, certain
information regarding options granted to, exercised by, and held at year end by,
Named Executive Officers:

                OPTION GRANTS IN FISCAL YEAR ENDED JUNE 30, 2000

<TABLE>
<CAPTION>
                                    INDIVIDUAL GRANTS                                     POTENTIAL REALIZABLE
                              -----------------------------                                 VALUE AT ASSUMED
                               NUMBER OF      % OF TOTAL                                  ANNUAL RATES OF STOCK
                              SECURITIES        OPTIONS                                  PRICE APPRECIATION FOR
                              UNDERLYING      GRANTED TO      EXERCISE OF                    OPTION TERM (1)
                                OPTION       EMPLOYEES IN     BASE PRICE    EXPIRATION   -----------------------
NAME                          GRANTED (#)   FISCAL YEAR (2)   ($/SH) (3)       DATE        5% ($)      10% ($)
----                          -----------   ---------------   -----------   ----------   ----------   ----------
<S>                           <C>           <C>               <C>           <C>          <C>          <C>
Benjamin F. McGraw III,
  Pharm.D...................    25,838           2.42%          $ 5.50       7/20/09      $ 89,372     $226,485
                                81,662           7.66             5.50       7/20/09       282,462      715,815

Bennet L. Weintraub.........    12,372           1.16             5.50       7/20/99        42,794      108,448
                                27,003           2.53             5.50       7/20/99        93,401      236,697

Alain Rolland, Pharm.D.,
  Ph.D......................    15,526           1.46             5.50       7/20/09        53,703      136,094
                                16,974           1.59             5.50       7/20/09        58,712      148,787
                                36,652           3.44             5.31       9/30/09       122,397      310,178
                                   462           0.04             5.31       9/30/09         1,543        3,910

Margaret M. Snowden.........    16,400           1.54             3.75       6/30/09        38,677       98,015
                                20,352           1.91            13.00       3/14/10       166,390      421,666
                                 9,648           0.90            13.00       3/14/10        78,878      199,894

Gillian E. Francis, M.B.,
  D.Sc. (Med) FRCPath.......    34,558           3.24             9.06        1/2/10       196,958      499,131
                                35,442           3.32             9.06        1/2/10       201,997      511,899
</TABLE>

------------------------

(1) Reflects the value of the stock option on the date of grant assuming
    (i) for the 5% column, a five-percent annual rate of appreciation in the
    Company's Common Stock over the ten-year term of the option and (ii) for the
    10% column, a ten-percent annual rate of appreciation in the Company's
    Common Stock over the ten-year term of the option, in each case without
    discounting to net present value and before income taxes associated with the
    exercise. The 5% and 10% assumed rates of appreciation are based on the
    rules of the Securities and Exchange Commission and do not represent the
    Company's estimate or projection of the future Common Stock price. The
    amounts in this table may not necessarily be achieved.

(2) Based on options to purchase 1,066,497 shares of the Company's Common Stock
    granted in fiscal year ended June 30, 2000.

(3) All options were granted at the fair market value at the date of grant.

                                       23
<PAGE>
   AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR AND FISCAL YEAR END OPTION
                                     VALUES

<TABLE>
<CAPTION>
                                                             NUMBER OF SECURITIES       VALUE OF UNEXERCISED IN-
                            SHARES                          UNDERLYING UNEXERCISED      THE-MONEY OPTIONS AT JUNE
                         ACQUIRED ON    VALUE REALIZED   OPTIONS AT JUNE 30, 2000 (#)        30, 2000 (2)($)
NAME                     EXERCISE (#)      ($) (1)        EXERCISABLE/UNEXERCISABLE     EXERCISABLE/UNEXERCISABLE
----                     ------------   --------------   ----------------------------   -------------------------
<S>                      <C>            <C>              <C>                            <C>
Benjamin F. McGraw III,
  Pharm.D..............        --               --           23,719 / 143,781             $139,349 / $885,026

Bennet L. Weintraub....        --               --            62,172 / 57,203             $300,035 / $276,059

Alain Rolland,
  Pharm.D., Ph.D.......        --               --            71,601 / 90,085             $252,876 / $571,177

Margaret M. Snowden....     6,000           36,750            4,668 / 52,998               $31,078 / $180,599

Gillian E. Francis,
  M.B., D. Sc. (Med)
  FRCPath..............        --               --              0 / 70,000                   $0 / $188,125
</TABLE>

------------------------

(1) Fair Market Value of the Company's Common Stock on date of exercise minus
    the exercise price.

(2) Fair Market Value of the Company's Common Stock on June 30, 2000 was $11.75
    minus the exercise price of the options.

                              CERTAIN TRANSACTIONS

    The Company has entered into indemnity agreements with certain officers and
directors which provide, among other things, that the Company will indemnify
such officer or director, under the circumstances and to the extent provided for
therein, for expenses, damages. Judgments, fines and settlements he may be
required to pay in actions or proceedings which he is or may be made a party by
reason of his position as a director, officer or other agent of the Company, and
otherwise to the full extent permitted under Delaware law and the Company's
By-laws.

         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS
                           ON EXECUTIVE COMPENSATION

COMPENSATION COMMITTEE REPORT(1)

    The Compensation Committee of the Board of Directors (the "Committee") is
composed of Drs. Crooke and Kucherlapati, neither of whom are currently officers
or employees of the Company. The Committee is responsible for establishing the
Company's compensation programs for all employees, including executives. For
executive officers, the Committee evaluates performance and determines
compensation policies and levels, as the Board requests.

EXECUTIVE COMPENSATION

    We design our executive compensation programs to attract and retain
executives who can lead Valentis to meet its business objectives and to motivate
them to enhance long-term stockholder value.

------------------------

(1) Notwithstanding anything to the contrary set forth in any of the Company's
    previous filings under the Securities Act of 1933, as amended, or the
    Exchange Act that might incorporate future filings, including this Proxy
    Statement, in whole or in part, the following report and performance graph
    on page 24 shall not be incorporated by reference into any such filings. The
    Committee's objective is to set executive compensation at competitive levels
    when compared to other companies in the biotechnology industry. The primary
    components of executive compensation are base salary, annual incentives and
    long-term equity incentives.

                                       24
<PAGE>
The executive officers' annual compensation consists of three elements: cash
salary, a cash incentive bonus and stock option grants.

    To determine fair compensation, the Compensation Committee reviews
historical and current salary, bonus and stock award information for other
comparable companies in similar geographic areas and at similar stages of growth
and development. The group of comparable companies is not necessarily the same
as the companies included in the market indices included in the performance
graph on page 24. The Compensation Committee also reviews a variety of industry
surveys throughout the year, which provide additional information about short
and long-term executive compensation. Based in part on this information, the
Compensation Committee generally sets salaries, including that of the Chief
Executive Officer, at levels comparable to competitive companies of comparable
size in similar industries. We structure our management bonus program around
both individual and Company performance. We base the total size of the bonus
pool on our success in meeting performance goals for the year, accounting for
changes the Compensation Committee discussed and agreed to during the course of
the year.

    We use the stock option program to give management employees a substantial
economic interest in the long-term appreciation of our Common Stock. We grant
existing members of management new options on an annual basis to provide a
continuing financial incentive. The size of the option grant is related to the
executive's position and performance in the previous year.

KEY ACCOMPLISHMENTS FOR FISCAL 2000

    We had the following achievements during Fiscal 2000 to further advance our
business objectives:

    - We rationalized and integrated the operations of Megabios and GeneMedicine
      to form Valentis, Inc. More significantly, we changed Valentis from a
      technology focus to a product focus. This has resulted in the development
      of a very deep portfolio of clinical candidates based on gene medicines.

    - We established Valentis as the leading non-viral gene delivery company
      based on breadth of technologies, intellectual property, scientific
      publications and products in development.

    - We merged Valentis with PolyMASC and converted PolyMASC from a technology
      focus to a product focus.

    - We advanced through pre-clinical development our interferon-a and IL-12
      cytokine combination gene medicine for treatment of solid tumors.

    - We advanced our del-1 gene medicine in pre-clinical product development
      for treatment of peripheral vascular and coronary artery diseases.

    - Our EPO gene plus GeneSwitch-TM- product was progressed through
      pre-clinical development.

    - We were issued a United States patent covering the use of the Company's
      PINC-TM- polymer system for the delivery of gene-based products to muscle.

    - We initiated a phase IIa clinical trial with our interferon-a (IFN-a) gene
      medicine for the treatment of malignant angioendothelioma, a rare form of
      vascular tumor.

    - We announced that in a double-blind, placebo-controlled phase II clinical
      trial, a non-viral VEGF(165) (Vascular endothelial growth factor) gene
      medicine incorporating one of the Company's proprietary cationic lipid
      gene delivery systems has shown evidence of stimulating angiogenesis
      (blood vessel formation).

    - We initiated a U.S.-based multi-center phase I/II clinical trial with our
      interleukin-12 (IL-12) gene medicine for the treatment of squamous cell
      carcinoma of the head and neck.

                                       25
<PAGE>
    - We initiated a feasibility collaboration with Boehringer Ingelheim.

    - We initiated a Phase II clinical trial of IL-2 gene medicine in
      combination with chemotherapy for the treatment of head and neck cancer.

                      CHIEF EXECUTIVE OFFICER COMPENSATION

    Dr. McGraw's salary during fiscal year end June 30, 2000 as President, Chief
Executive Officer and Chairman was $304,484. Following the Committee's review of
Dr. McGraw's performance and the Company's performance during fiscal year ended
June 30, 2000, the Committee set Dr. McGraw's annual salary for fiscal year
ending June 30, 2001 at $322,000. In addition, the Compensation Committee
approved a bonus of $91,155 in July 2000 for Dr. McGraw. In July 2000 the
Committee approved a stock option grant for 107,500 shares of Common Stock for
Dr. McGraw, which is within the guidelines for the CEO under our annual stock
options grant program. In approving Dr. McGraw's compensation, the Committee
took into account (i) Dr. McGraw's past performance as President, CEO and
Chairman of the Board of the Company, (ii) the scope of Dr. McGraw's
responsibilities, and (iii) the Board's assessment of the Company's achievement
of its performance objectives.

                           FEDERAL TAX CONSIDERATIONS

    Section 162(m) of the Internal Revenue Code (the "Code") limits the Company
to a deduction for federal income tax purposes of no more than 1 million of
compensation paid to certain Named Executive Officers in a taxable year.
Compensation above $1 million may be deducted if it is "performance-based
compensation" within the meaning of the Code.

    The statute containing this law and the applicable Treasury regulations
offer a number of transitional exceptions to this deduction limit for
pre-existing compensation plans, arrangements and binding contracts. As a
result, the Compensation Committee believes that at the present time it is quite
unlikely that the compensation paid to any named Executive Officer in a taxable
year which is subject to the deduction limit will exceed $1 million. Therefore,
the Compensation Committee has not yet established a policy for determining
which forms of incentive compensation awarded to its Named Executive Officers
shall be designed to qualify as "performance-based compensation." The
Compensation Committee intends to continue to evaluate the effects of the
statute and any applicable Treasury regulations and to comply with Code
Section 162(m) in the future to the extent consistent with the best interests of
the Company.

                                   CONCLUSION

    A significant portion of the Company's compensation program and
Dr. McGraw's compensation are contingent on Company performance, and realization
of benefits is closely linked to increases in long-term stockholder value. The
Company remains committed to this philosophy of pay for performance, recognizing
that the competitive market for talented executives and the volatility of the
Company's business may result in highly variable compensation for a particular
time period.

COMPENSATION COMMITTEE
Stanley T. Crooke, M.D., Ph.D.
Raju Kucherlapati, Ph.D.
Arthur M. Pappas

                                       26
<PAGE>
                     PERFORMANCE MEASUREMENT COMPARISON(1)

    The following graph shows the total stockholder return of an investment of
$100 in cash on September 15, 1997 for (i) the Company's Common Stock, (ii) the
Nasdaq Stock Market-U.S. Index (the "Nasdaq Stock Market-U.S.") and (iii) the
Nasdaq Pharmaceutical Index (the "Nasdaq Pharmaceutical"). All values assume
reinvestment of the full amount of all dividends and are calculated as of
September 30, 2000:

              COMPARISON OF CUMULATIVE TOTAL RETURN ON INVESTMENT
<TABLE>
<CAPTION>
                                             1997                                  1998                             1999
                                ------------------------------   -----------------------------------------   -------------------
                                 09/15      09/30      12/31      03/31      06/30      09/30      12/30      03/31      06/30
                                --------   --------   --------   --------   --------   --------   --------   --------   --------
<S>                             <C>        <C>        <C>        <C>        <C>        <C>        <C>        <C>        <C>
Valentis......................     100.0      137.5      118.8       77.1       63.5       42.7       42.7       34.4       31.8
NASDAQ Composite Index........     100.0      103.1       96.1      112.3      115.9      103.6      134.1      150.6      164.3
NASDAQ Biotech Index..........     100.0      104.7       92.8      103.6       97.1       97.5      133.9      152.5      155.3

<CAPTION>
                                       1999                        2000
                                -------------------   ------------------------------
                                 09/30      12/31      03/31      06/30      09/30
                                --------   --------   --------   --------   --------
<S>                             <C>        <C>        <C>        <C>        <C>
Valentis......................      42.2       75.0       94.8       97.9       68.8
NASDAQ Composite Index........     168.0      248.9      279.7      242.6      224.6
NASDAQ Biotech Index..........     180.4      269.9      314.1      372.5      402.6
</TABLE>

------------------------------

(1) This Section is not "soliciting material," is not deemed "filed" with the
    SEC and is not to be incorporated by reference in any filing of the Company
    under the 1933 Act or the 1934 Act whether made before or after the date
    hereof and irrespective of any general incorporation language in any such
    filing.

                                       27
<PAGE>
                                 OTHER MATTERS

    The Board of Directors knows of no other matters that will be presented for
consideration at the Annual Meeting. If any other matters are properly brought
before the meeting, it is the intention of the persons named in the accompanying
proxy to vote on such matters in accordance with their best judgment.

    For further information about Valentis, Inc., please request a copy of our
Annual Report on Form 10-K which we previously filed with the Securities &
Exchange Commission, and is available free of charge. Please access via the
Valentis website at www.valentis.com under the Investor Relations section, or
send written requests to:

                                 Valentis, Inc.
                                863A Mitten Rd.
                              Burlingame, CA 94010
                            Attn: Investor Relations

                                          By Order of the Board of Directors

                                          /s/ Alan C. Mendelson

                                          Alan C. Mendelson
                                          Secretary

November 6, 2000

                                       28
<PAGE>
                                                                       EXHIBIT A

                            AUDIT COMMITTEE CHARTER
                                 VALENTIS, INC.

ORGANIZATION

    There shall be a committee of the board of directors to be known as the
audit committee. The audit committee shall be composed of directors who are
independent of the management of the corporation and are free of any
relationship that, in the opinion of the board of directors, would interfere
with their exercise of independent judgment as a committee member. All committee
members shall be financially literate, or shall become financially literate
within a reasonable period of time after appointment to the committee, and at
least one member shall have accounting or related financial management
expertise.

STATEMENT OF POLICY

    The audit committee shall provide assistance to the corporate directors in
fulfilling their responsibilities to the shareholders, potential shareholders,
and investment community relating to corporate accounting, reporting practices
of the corporation, the quality and integrity of the financial reports of the
corporation and the legal compliance and ethics programs as established by
management and the board. In so doing, it is the responsibility of the audit
committee to maintain free and open means of communication between the
directors, the independent auditors, the internal auditors (as applicable), and
the financial management of the corporation responsible for preparing the
Company's financial statements.

RESPONSIBILITIES

    In carrying out its responsibilities, the audit committee believes its
policies and procedures should remain flexible, in order to best react to
changing conditions and to ensure to the directors and shareholders that the
corporate accounting and reporting practices of the corporation are in
accordance with all requirements and are of the highest quality.

    In carrying out these responsibilities, the audit committee will:

    - Review and recommend to the directors the independent auditors to be
      selected to audit the financial statements of the corporation and its
      divisions and subsidiaries.

    - Receive from the outside auditors a formal written statement delineating
      all relationships between the auditor and the company, consistent with
      Independence Standards Board Standard 1.

    - Maintain an active dialogue with the auditor with respect to any disclosed
      relationships or services that may impact the objectivity and independence
      of the auditor and recommend that the full board take appropriate action
      to oversee the independence of the outside auditor.

    - Meet with the independent auditors and financial management of the
      corporation to review the scope of the proposed audit for the current year
      and the audit procedures to be utilized, and at the conclusion thereof
      review such audit, including any comments or recommendations of the
      independent auditors.

    - Review with the independent auditors, the company's internal auditor, and
      financial and accounting personnel, the adequacy and effectiveness of the
      accounting and financial controls of the corporation, and elicit any
      recommendations for the improvement of such internal control procedures or
      particular areas where new or more detailed controls or procedures are
      desirable.

                                      A-1
<PAGE>
      Particular emphasis should be given to the adequacy of such internal
      controls to expose any payments, transactions, or procedures that might be
      deemed illegal or otherwise improper. Further, the committee periodically
      should review company policy statements to determine their adherence to
      the code of conduct.

    - Review the internal audit function of the corporation including the
      independence and authority of its reporting obligations, the proposed
      audit plans for the coming year, and the coordination of such plans with
      the independent auditors.

    - Receive prior to each meeting, a summary of findings from completed
      internal audits and a progress report on the proposed internal audit plan,
      with explanations for any deviations for the original plan.

    - Review the financial statements contained in the annual report on
      Form 10-K (or the annual report to shareholders if distributed prior to
      the filing of Form 10k) with management and the independent auditors to
      determine that the independent auditors are satisfied with the disclosure
      and content (including their judgment about the quality, not just
      acceptability, of accounting principles; the reasonableness of significant
      judgments; and the clarity of the disclosures in the financial statements.
      Also, the committee shall discuss the results of the annual audit and any
      other matters required to be communicated to the committee by the
      independent auditors under generally accepted auditing standards) of the
      financial statements to be presented to the shareholders. Any changes in
      accounting principles should be reviewed.

    - Review the interim financial statements with management and the
      independent auditors prior to the filing of the Company's Quarterly Report
      on Form 10-Q. Also, the committee shall discuss the results of the
      quarterly review and any other matters required to be communicated to the
      committee by the independent auditors under generally accepted auditing
      standards. The chair of the committee may represent the entire committee
      for the purposes of this review.

    - Provide sufficient opportunity for the internal and independent auditors
      to meet with the members of the audit committee without members of
      management present. Among the items to be discussed in these meetings are
      the independent auditors' evaluation of the corporations' financial,
      accounting, and auditing personnel, and the cooperation that the
      independent auditors receive during the course of the audit.

    - Review accounting and financial human resources and succession planning
      within the company.

    - Submit the minutes of all meetings of the audit committee to, or discuss
      the matters discussed at each committee meeting with, the board of
      directors.

    - Investigate any matter brought to its attention within the scope of its
      duties, with the power to retain outside counsel for this purpose, if in
      its judgment, that is appropriate.

    Ensure the outside auditor's ultimate accountability to the board of
directors and the audit committee, as representatives of shareholders; and these
shareholder representatives' ultimate authority and responsibility to select,
evaluate, and where appropriate, replace the outside auditor (or nominate the
outside auditor to be proposed for shareholder approval in any proxy statement).

                                      A-2
<PAGE>
                                                                      1566-PS-00
<PAGE>

PROXY

                                 VALENTIS, INC.

                                863A MITTEN ROAD
                          BURLINGAME, CALIFORNIA 94010

                       SOLICITED BY THE BOARD OF DIRECTORS
                     FOR THE ANNUAL MEETING OF STOCKHOLDERS

     The undersigned hereby appoints Bennet L. Weintraub and Benjamin McGraw,
III, Pharm.D., or either of them, each with the power of substitution, and
hereby authorizes them to represent and to vote, as designated on the reverse
side, all shares of common stock of Valentis, Inc. (the "Company") held of
record by the undersigned on October 30, 2000 at the Annual Meeting of
Stockholders to be held on December 12, 2000 and any adjournments thereof.

     THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED AS DIRECTED, IF NO
DIRECTION IS GIVEN WITH RESPECT TO A PARTICULAR PROPOSAL, THIS PROXY WILL BE
VOTED FOR SUCH PROPOSAL.

     PLEASE MARK, DATE, SIGN, AND RETURN THIS PROXY CARD PROMPTLY, USING THE
ENCLOSED ENVELOPE, NO POSTAGE IS REQUIRED IF MAILED IN THE UNITED STATES.

<TABLE>
<S><C>
---------------                                                                 ---------------
   SEE REVERSE             CONTINUED AND TO BE SIGNED ON REVERSE SIDE             SEE REVERSE
       SIDE                                                                          SIDE
---------------                                                                 ---------------
</TABLE>

Dear Stockholder:

Please take note of the important information enclosed with this Proxy. There
are a number of issues related to the operation of the Company that require your
immediate attention.

Your vote counts, and you are strongly encouraged to exercise your right to vote
your shares.

Please mark the boxes on the proxy card to indicate how your shares will be
voted. Then sign the card, detach it and return your prompt consideration of
these matters.

Sincerely,

Valentis, Inc.


                                   DETACH HERE
-------------------------------------------------------------------------------



<PAGE>



/X/ PLEASE MARK VOTES AS IN THIS EXAMPLE.

MANAGEMENT RECOMMENDS A VOTE FOR THE NOMINEES LISTED IN PROPOSAL 1 AND FOR
PROPOSALS 2 THROUGH 5.

1.   Election of Directors.

NOMINEE:  Raju Kucherlapati        Bert W. O'Malley        Mark McDade
          FOR [ ]   WITHHELD [ ]   FOR [ ]   WITHHELD [ ]  FOR [ ]  WITHHELD [ ]


2. Approve an amendment to the Company's 1997 Equity Incentive Plan to increase
the aggregate number of shares of Common Stock authorized for issuance
thereunder by 2,000,000 shares.

     FOR [ ]              AGAINST [ ]              ABSTAIN [ ]

3. Approve an amendment to the Company's 1998 Non-Employee Directors' Stock
Option Plan to increase the aggregate number of shares of Common Stock
authorized for issuance thereunder by 200,000 shares.

     FOR [ ]              AGAINST [ ]              ABSTAIN [ ]

4. Approve an amendment to the Company's Employee Stock Purchase Plan to
increase the aggregate number of shares of Common Stock authorized for issuance
thereunder by 200,000 shares.

     FOR [ ]              AGAINST [ ]              ABSTAIN [ ]

5. Ratify the selection of Ernst & Young LLP as independent auditors for the
fiscal year ending June 30, 2001.

     FOR [ ]              AGAINST [ ]              ABSTAIN [ ]

6. In their discretion, the proxies are authorized to vote upon any other
business that may properly come before the meeting.

     Mark here for address change and notification [ ]

Please sign exactly as name appears hereon. Joint owners should each sign.
Executors, administrators, trustees, guardians or other fiduciaries should give
full title as such. If signing for a corporation, please sign in full corporate
name by a duly authorized officer.

Signature: ____________ Date: _________    Signature: __________ Date: _________




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