OSTEX INTERNATIONAL INC /WA/
DEF 14A, 1997-04-25
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                            SCHEDULE 14A INFORMATION
                  PROXY STATEMENT PURSUANT TO SECTION 14(A) OF
                      THE SECURITIES EXCHANGE ACT OF 1934


 [X]  Filed by the Registrant
 [ ]  Filed by a party other than the Registrant

Check the appropriate box:
    [ ]  Preliminary Proxy Statement
    [ ]  Confidential, for Use of the Commission Only [as permitted by Exchange
         Act Rule 14(a)-6(e)(2)]
    [X]  Definitive Proxy Statement
    [ ]  Definitive Additional Material
    [ ]  Soliciting Material Pursuant to ss. 240.14a-11(c) or ss. 240.14a-12
    


                            OSTEX INTERNATIONAL, INC.
                (NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER)




Payment of Filing Fee:

    [X]  No fee required.
    [ ]  $125 per Exchange Act Rule 0-11(c)(1)(ii), 14a-6(i)(1) or 14a-6(i)(2),
         or Item 22(a)(2) of Schedule 14A.

    [ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) 
         and 0-11:
         (1)  Title of each class of securities to which transaction applies:
         (2)  Aggregate number of securities to which transaction applies:
         (3)  Per unit price or other underlying  value of transaction  computed
              pursuant to Exchange  Act Rule 0-11 (set forth the amount on which
              filing fee is calculated and how determined):
         (4)  Proposed maximum aggregate value of transaction:
         (5)  Total fee paid:

    [ ]  Fee paid previously with written preliminary materials.

    [ ]  Check box if any part of the fee is offset as provided by Exchange Act
         Rule 0-11(a)(2) and identify the filing for which the offsetting fee 
         was paid previously.  Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing:
         (1)  Amount previously paid:
         (2)  Form, schedule or registration statement number:
         (3)  Filing party:
         (4)  Date filed:


<PAGE>


                                  [OSTEX LOGO]






                            OSTEX INTERNATIONAL, INC.
                        2203 Airport Way South, Suite 400
                            Seattle, Washington 98134



                                 April 23, 1997


Dear Shareholder:

         You are cordially  invited to attend the Annual Meeting of Shareholders
of Ostex International, Inc. to be held on Monday, June 2, 1997, at 9:00 a.m. at
the  Bellevue  Athletic  Club,  located  at  11200  SE  6th  Street,   Bellevue,
Washington.

         The matters to be acted upon are described in the  accompanying  Notice
of Annual Meeting of Shareholders and Proxy Statement. At the Annual Meeting, we
will also  report on Ostex's  operations  and respond to any  questions  you may
have.

         Whether or not you plan to attend the Annual  Meeting,  it is important
that your shares be represented and voted.  THEREFORE,  PLEASE  COMPLETE,  SIGN,
DATE  AND  MAIL  THE  ENCLOSED  PROXY  AS  SOON  AS  POSSIBLE  IN  THE  ENCLOSED
POSTAGE-PREPAID  ENVELOPE.  Returning  the  enclosed  proxy will not affect your
right to  revoke it later or to vote your  shares  in person if you  attend  the
Annual Meeting.

                                Very truly yours,


                                /S/ H. RAYMOND CAIRNCROSS

                                H. Raymond Cairncross
                                CHAIRMAN OF THE BOARD
                                AND CHIEF EXECUTIVE OFFICER


<PAGE>


                            OSTEX INTERNATIONAL, INC.
                        2203 Airport Way South, Suite 400
                            Seattle, Washington 98134

                    NOTICE OF ANNUAL MEETING OF SHAREHOLDERS
                             TO BE HELD JUNE 2, 1997


To the Shareholders of Ostex International, Inc.:

         The Annual Meeting of the  Shareholders  of Ostex  International,  Inc.
(the "Company") will be held at the Bellevue Athletic Club,  located at 11200 SE
6th Street, in Bellevue,  Washington, on June 2, 1997, at 9:00 a.m. If you would
like directions,  please call the Company at (206) 292-8082.  The Annual Meeting
is held for the following purposes:

         1.       To elect two directors to the Company's Board of Directors;

         2.       To approve proposed amendments to the Company's 1994 Stock 
                  Option Plan;

         3.       To approve proposed amendments to the Company's Directors' 
                  Nonqualified Stock Option Plan;

         4.       To ratify the  selection of Arthur  Andersen LLP as the  
                  Company's  independent  auditors for the fiscal year ending 
                  December 31, 1997; and

         5.       To  transact  such  other  business  as may  properly  come
                  before  the  Annual  Meeting  or any adjournment or 
                  postponement thereof.

         The foregoing  items of business are more fully  described in the Proxy
Statement accompanying this Notice.

         The  record  date for the  Annual  Meeting  is  April  16,  1997.  Only
shareholders  of record at the close of  business  on that date are  entitled to
notice of, and to vote at, the Annual Meeting or any adjournment or postponement
thereof.

                                By Order of the Board of Directors


                                /S/ JEFFREY J. MILLER

                                Jeffrey J. Miller
                                SECRETARY

Seattle, Washington
April 23, 1997



         ALL  SHAREHOLDERS  ARE CORDIALLY  INVITED TO ATTEND THE ANNUAL MEETING.
WHETHER OR NOT YOU EXPECT TO ATTEND THE ANNUAL MEETING,  PLEASE  COMPLETE,  SIGN
AND DATE THE  ENCLOSED  PROXY AND RETURN IT AS SOON AS POSSIBLE IN THE  ENCLOSED
POSTAGE-PREPAID  ENVELOPE IN ORDER TO ENSURE YOUR REPRESENTATION AT THE MEETING.
THE GIVING OF SUCH  PROXY DOES NOT AFFECT  YOUR RIGHT TO REVOKE IT LATER OR VOTE
YOUR SHARES IN PERSON IN THE EVENT THAT YOU SHOULD ATTEND THE ANNUAL MEETING.


<PAGE>






                            OSTEX INTERNATIONAL, INC.
                                 PROXY STATEMENT

                                     FOR THE
                         ANNUAL MEETING OF SHAREHOLDERS
                             TO BE HELD JUNE 2, 1997
                       ----------------------------------

                 INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

         This enclosed proxy is solicited on behalf of the Board of Directors of
Ostex International, Inc., a Washington corporation (the "Company"), to be voted
at the Company's 1997 Annual Meeting of Shareholders (the "Annual Meeting"),  to
be held at 9:00 a.m. on Monday,  June 2, 1997,  at the Bellevue  Athletic  Club,
located at 11200 SE 6th Street, in Bellevue,  Washington,  or at any adjournment
or postponement  thereof,  for the purposes set forth in the accompanying Notice
of Annual Meeting of Shareholders.  Any shareholder  requiring directions to the
Bellevue Athletic Club should call the Company at (206) 292-8082.

VOTING AND OUTSTANDING SHARES

         Only holders of record of Company  common  stock,  $0.01 par value (the
"Common  Stock"),  at the close of business on April 16,  1997,  are entitled to
notice of and to vote at the Annual  Meeting.  At the close of business on April
16,  1996,  there were  outstanding  and entitled to vote  12,447,617  shares of
Common Stock.  Shareholders  of record on such date are entitled to one vote for
each share of Common  Stock  held on all  matters to be voted upon at the Annual
Meeting.  All votes will be tabulated by the inspector of election appointed for
the Annual Meeting, who will separately tabulate affirmative and negative votes,
abstentions and broker nonvotes.

         The  presence  in person or by proxy of holders of record of a majority
of the outstanding  shares of Common Stock is required to constitute a quorum at
the  Annual  Meeting.  Under  Washington  law  and  the  Company's  Articles  of
Incorporation,  assuming the presence of a quorum, the election of the Company's
directors requires a plurality of votes cast, and the other proposals  described
in the  accompanying  Notice to  Shareholders  (including  the  approval  of the
amendments  to the 1994 Stock Option Plan (the "1994  Plan") and the  Directors'
Nonqualified  Stock Option Plan (the "Directors'  Plan")) require that the votes
cast in favor exceed the votes cast against the proposal.

         Abstentions and "broker  nonvotes" (shares by a broker or nominee as to
which a broker  or  nominee  indicates  on the  proxy  that it does not have the
authority, either express or discretionary,  to vote on a particular matter) are
counted for purposes of determining  the presence of a quorum.  For the election
of directors,  an abstention from voting and broker nonvotes will not be counted
either in favor or against the nominees.  For all other  matters,  an abstention
from voting and broker nonvotes will have the practical effect as a vote against
the respective matters because they are not affirmative votes.

REVOCABILITY OF PROXIES

         Any person giving a proxy pursuant to this  solicitation  has the power
to revoke it at any time  before it is voted.  It may be revoked by filing  with
the Secretary of the Company at the Company's  principal  executive office, 2203
Airport Way South,  Suite 400,  Seattle,  Washington  98134, a written notice of
revocation or a duly  executed  proxy bearing a later date, or it may be revoked
by attending the Annual Meeting and voting in person.
Attendance at the Annual Meeting will not, by itself, revoke a proxy.

SOLICITATION

         The  Company  will bear the entire  cost of  solicitation  of  proxies,
including  preparing,  printing and mailing this Proxy Statement,  the proxy and
any  additional  information  furnished to  shareholders.  The Company will also

<PAGE>

request brokerage firms, banks, nominees,  custodians and fiduciaries to forward
proxy  materials  to the  beneficial  owners of shares of Common Stock as of the
record date. The Company will provide  reimbursement  for the cost of forwarding
the proxy  materials  in  accordance  with  customary  practice.  In addition to
mailing of this Proxy  Statement  and the  accompanying  proxy,  proxies  may be
solicited by  directors,  officers and other  employees of the Company,  without
additional  compensation,  in person or by  telephone,  telegraph  or  facsimile
transmission.  The Company may also use a proxy  solicitation  firm and will pay
commercially reasonable fees for required services not to exceed $5,000.

         This Proxy Statement and accompanying proxy card are first being mailed
to shareholders on or about April 23, 1997.


                                   PROPOSAL 1:
                 ELECTION OF DIRECTORS AND DIRECTOR INFORMATION


         The Company's  Articles of Incorporation  (the  "Articles")  divide the
Board of  Directors  into three  classes,  each class  consisting,  as nearly as
possible,  of one-third of the total  number of  directors.  The members of each
class are  elected to serve for a  three-year  term and until the  election  and
qualification of their successors.  At each annual meeting of shareholders,  one
class of the Board of  Directors is elected and  directors in the other  classes
remain in office  until their  respective  three-year  terms  expire.  Under the
Company's  Amended Bylaws,  the Board of Directors is to be comprised of no more
than nine  members  and no fewer than five  members,  the exact  number of which
shall be set by the Board of Directors from time to time. The Board of Directors
currently consists of six directors.

         At the  Annual  Meeting,  shareholders  will  be  asked  to  elect  two
directors  to the class whose term of office will expire at the year 2000 annual
meeting of shareholders (the "Class 1" Directors).  The nominees for election as
director  are Dr. David R. Eyre and Dr.  Fredric J.  Feldman.  Unless  otherwise
directed,  the persons named in the proxy intend to cast all proxies in favor of
Drs.  Eyre and Feldman to serve as Class 1 Directors.  Both nominees have agreed
to serve if elected and  management  has no reason to believe  that they will be
unable to serve, but if either of them is not able to serve, it is intended that
the proxies will be voted for the election of such nominee as  designated by the
Board of Directors to fill any such vacancy.

         The  nominees  for  director  for  any  class  will be  elected  by the
plurality of the votes cast in such class.


INFORMATION ABOUT THE DIRECTOR NOMINEES

         DAVID R. EYRE,  PH.D. (age 53) is a founder of the Company and has been
a Director since the Company's  formation in May 1989. Dr. Eyre currently serves
on the  Nominating  Committee  of the Board of  Directors.  His  major  research
interests include collagen  biochemistry,  inborn skeletal  diseases,  cartilage
pathology,   biochemistry  of  the  intervertebral  disc,  bone  metabolism  and
osteoporosis.   Since  1985,  Dr.  Eyre  has  served  as  Burgess  Professor  of
Orthopedics at the University of Washington,  where he is also Adjunct Professor
of  Biochemistry  and Oral  Biology  and  Director  of the  Orthopedic  Research
Laboratories.  Dr.  Eyre  has  previously  served  as a  research  scientist  at
Children's  Hospital Medical Center in Boston,  Massachusetts,  and as a faculty
member in the Department of Biological  Chemistry at Harvard Medical School.  In
addition,  Dr. Eyre has served on the permanent  scientific staff of the Kennedy
Institute  of  Rheumatology  in London,  England,  and as a  Research  Fellow at
Massachusetts  General  Hospital  and  Harvard  Medical  School.  Dr.  Eyre  has
published  numerous articles on the biochemistry of connective  tissue. Dr. Eyre
earned his Ph.D. and B.S. in biochemistry from the University of Leeds, England.

       FREDRIC J.  FELDMAN,  PH.D.  (age 57) has served as the  President of FJF
Associates  since 1992, a firm providing  management  and investment  consulting
services to venture  capital and  emerging  growth  companies in the health care
industry.  From 1995 to 1996, Dr. Feldman served as the interim Chief  Executive
Officer of Biex,  Inc., a biotechnology  company focused on women's health care,
from 1992 to 1995 as the  Chairman of the Board and Chief  Executive  Officer of
Oncogenetics,  Inc., a genetic cancer diagnostic company,  and from 1988 to 1992

<PAGE>

as  President  and  Chief  Executive  Officer  of  Microgenic   Corporation,   a
biotechnology  diagnostic  company.  Dr.  Feldman  received a Ph.D.  and M.S. in
chemistry  from the University of Maryland and a B.S. in chemistry from Brooklyn
College of City University of New York.

         THE BOARD OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE ELECTION OF EACH OF
THE DIRECTOR NOMINEES.

INFORMATION ABOUT DIRECTORS WHOSE TERMS OF OFFICE CONTINUE AFTER 
THE ANNUAL MEETING

DIRECTORS WHOSE TERMS EXPIRE IN 1998

         ROBERT J. GLASER (age 45) has been the Company's  President and Chief
Operating  Officer since April 1996 and a Director of the Company since May
1995. Mr. Glaser served on the Audit  Committee of the Board of Directors  until
he became an officer of the Company in April 1996. Prior to joining the Company,
Mr.  Glaser held a variety of U.S.  and  international  positions at Merck & Co.
("Merck"),  a  pharmaceutical  company,   including  positions  as  Senior  Vice
President, Marketing, U.S. Human Health from January 1994 to April 1996, as Vice
President,  Marketing,  Merck Human  Health  Division  from June 1993 to January
1994, as Vice President,  Merck Vaccine Division,  from March 1993 to June 1993,
as Vice President, Sales & Marketing, Merck Vaccine Division, from 1991 to 1993,
and as Executive Director of Marketing, Merck, Sharp & Dohme, from 1989 to 1991.
Mr. Glaser received an M.B.A. from the Kellogg School at Northwestern University
and a B.A. from Gettysburg College.

         GREGORY D. PHELPS  (age 48) has been a Director  of the  Company  since
November 1995 and is serving on the  Compensation  and Nominating  Committees of
the Board of Directors.  Mr. Phelps has been Executive Vice President of Genzyme
Corporation, a biotechnology company, since 1991. Mr. Phelps served as President
and Chief Executive Officer of Viagene,  Inc., a biotechnology  company focusing
on development  of gene  therapies for viral diseases and cancers,  from 1988 to
1990,  and as President and Chief  Executive  Officer of  ZymoGenetics,  Inc., a
company developing  biotherapeutic  products, from 1986 to 1988. His career also
includes management  positions with Baxter  International,  a general healthcare
company,  from  1975  to  1986,  where  he was  Vice  President  of  the  Hyland
Therapeutics  Division.  Mr.  Phelps  received an M.B.A.  from Harvard  Business
School and a B.S. from Bradley University.

DIRECTORS WHOSE TERMS EXPIRE IN 1999

         THOMAS J.  CABLE (age 57) has been a  Director  of the  Company  since
1989  and  currently  serves  on the  Audit,  Compensation  and  Nominating
Committees  of the Board of Directors.  Mr. Cable is  co-founder  and partner of
Cable & Howse Ventures,  Inc., a venture management company founded in 1979. Mr.
Cable was also  co-founder  and,  from 1982 to 1985,  a partner in Cable Howse &
Ragen,  a  Seattle  investment  banking  and  brokerage  firm now known as Ragen
MacKenzie.  Mr.  Cable is a  founder  and  current  Chairman  of the  Washington
Research Foundation and serves on the board of directors of Mycogen Corporation,
an  agricultural  biotechnology  company,  Fischer  Imaging,  an x-ray equipment
manufacturer for mammography,  EndoSonics,  an intravascular ultrasound company,
Molecular  Simulations,  a computation  chemistry  software company,  and Omeros
Medical  Systems,  Inc., a company  developing  orthopedic  surgical devices and
products.  Mr. Cable earned an M.B.A from  Stanford  University  and a B.A. from
Harvard College.

         H. RAYMOND CAIRNCROSS (age 55) is a founder of the Company and has been
Chairman of the Board of Directors since 1989 and Chief Executive  Officer since
1991.  From 1991 to April 1996, Mr.  Cairncross  also served as President of the
Company.  In 1987,  Mr.  Cairncross  founded  Cairncross &  Hempelmann,  P.S., a
Seattle law firm of which he previously served as Managing Partner and currently
is a nonpracticing shareholder and a director. Mr. Cairncross is a member of the
board of directors of Information Optics Corporation,  a company developing high
speed  computer  memory  systems,  and Omeros Medical  Systems,  Inc., a company
developing  orthopedic surgical devices and products.  Mr. Cairncross received a
J.D. and a B.A. from Stanford University.

<PAGE>


COMPENSATION OF DIRECTORS

         The Company does not pay any cash  compensation to directors serving in
that  capacity,  although  directors are reimbursed  actual travel  expenses for
attendance  at  Board  of  Directors  and  committee  meetings.   The  Company's
nonemployee directors participate in the Company's Directors Plan. The Directors
Plan, as proposed to be amended, is described below under "Proposal 3: Amendment
to the Directors Plan."

BOARD COMMITTEES

         The Company's Board of Directors has standing Audit, Compensation and
Nominating Committees.

         The Audit  Committee  currently  consists  of Mr.  Cable.  The Board of
Directors  intends to appoint  Dr.  Feldman to the  committee  if elected at the
Annual Meeting by the shareholders. The Audit Committee makes recommendations to
the Board of Directors regarding the selection of independent auditors,  reviews
the results and scope of the audit and other services  provided by the Company's
independent  auditors,  and reviews and evaluates the Company's internal control
functions. The Audit Committee did not meet in 1996.

         The  Compensation  Committee  currently  consists of Messrs.  Cable and
Phelps.  The  Compensation  Committee  administers the Company's  employee stock
option  plans and makes  recommendations  to the Board of  Directors  concerning
compensation  for  executive  officers  and  consultants  of  the  Company.  The
Compensation Committee met one time in 1996.

         The Nominating Committee currently consists of Messrs. Cable and Phelps
and Dr. Eyre.  The  Nominating  Committee  administers  the search  process,  if
necessary, for new members of the Company's Board of Directors and may recommend
executive  officers to the Board of  Directors.  Shareholders  intending to make
Board of Directors  recommendations  must provide  written notice of such intent
not later than 120 days in advance of the date of an annual shareholders meeting
with  information   regarding  such  nominee.   The  Nominating   Committee  was
established in April 1997.

BOARD MEETINGS

         During 1996,  there were five  meetings of the Board of  Directors  and
each director  attended at least 75% of the aggregate  number of Board  meetings
and meetings of committees on which he served.



<PAGE>



                             EXECUTIVE COMPENSATION

EXECUTIVE COMPENSATION

         SUMMARY  COMPENSATION  TABLE.  The  following  table sets forth certain
information  regarding  compensation  paid during the years ended  December  31,
1996, 1995 and 1994 to (i) the Company's  Chief Executive  Officer and (ii) each
of the  Company's  executive  officers  who earned  more than  $100,000  in 1996
(collectively, the "Named Executive Officers").

<TABLE>
<CAPTION>

                                         Annual Compensation                 Long Term Compensation
                                ----------------------------------------- -----------------------------
     Name and Principal                                    Other Annual       Securities Underlying          All Other
          Position                Year        Salary       Compensation            Options (#)              Compensation
- -----------------------------   ----------------------------------------- -----------------------------  -----------------
<S>                              <C>         <C>           <C>                      <C>                     <C>

H. Raymond Cairncross,
Chairman of the Board             1996       $ 250,000          -                      -                        -
and Chief Executive Officer       1995       $ 250,000          -                      -                        -
                                  1994       $ 168,000          -                   500,000                 $ 40,000
Robert J. Glaser, Director,
President and Chief               1996       $ 174,000          -                   200,000                     -
Operating Officer                 1995            -             -                    10,000                     -
                                                                                                         
William K. Strelke, Vice          1996       $ 125,000     $ 24,000 (1)              12,500                     -
President, Sales &                1995       $ 124,000     $ 36,000 (1)              20,000                     -
Marketing                         1994        $ 84,000      $ 5,000 (1)              37,500                     -

- -------

<FN>
(1)      Represents commissions earned.
</FN>
</TABLE>

       OPTION GRANTS IN 1996. The following table sets forth certain information
regarding stock options granted to the Named Executive  Officers during the year
ended December 31, 1996.

<TABLE>
<CAPTION>

                              SHARES      PERCENTAGE OF                                  OF STOCK PRICE
                            UNDERLYING    TOTAL OPTIONS    EXCERCISE                    APPRECIATION FOR
                              OPTIONS       GRANTED TO     PRICE PER  EXPIRATION           OPTION TERM
NAME                        GRANTED (#)     EMPLOYEES      SHARE (1)     DATE           5%            10%
- ----                        -----------     ---------      ---------     ----           --            ---
<S>                           <C>             <C>           <C>        <C>         <C>            <C>

H. Raymond Cairncross            -              0%             -          N/A            -             -
Robert J. Glaser              200,000          45%          $ 14.00    4/15/2006   $ 1,761,000    $ 4,462,000
William K. Strelke             12,500           3%          $ 10.75    7/1/2006    $    85,000    $   214,000

- -------

<FN>
(1)   In February  1997,  the Board of Directors  repriced all stock options
        granted during 1996 to $5.75, the fair market value of the Common Stock
        as reported on the repricing date.
</FN>
</TABLE>


<PAGE>



       OPTION EXERCISES AND YEAR END OPTION VALUES FOR 1996. The following table
sets forth certain  information  regarding  options exercised during 1996 by the
Named Executive Officers and the value of such persons'  unexercised  options at
December 31, 1996.

<TABLE>
<CAPTION>
                                                                       NUMBER OF                          VALUE OF
                                                                        SHARES                          UNEXERCISED
                                   SHARES                             UNDERLYING                          IN-THE
                                  ACQUIRED                            UNEXERCISED                          MONEY
                                 ON EXERCISE     VALUE                OPTIONS AT                         OPTIONS AT
                                      #         REALIZED                FISCAL                             FISCAL
             NAME                                 ($)                  YEAR END                         YEAR END (1)
            ------               ----------      -----                 --------                         ------------

                                                             EXERCISABLE    UNEXERCISABLE       EXERCISABLE       UNEXERCISABLE
                                                             -----------    -------------       -----------       -------------
<S>                                 <C>           <C>          <C>             <C>                <C>                <C>

H. Raymond Cairncross                 -            -           545,500         250,000            $757,850           $125,000
Robert J. Glaser                      -            -             3,333         200,000               -                  -
William K. Strelke                    -            -            23,750          46,250             $9,375             $9,375


- ------

<FN>
(1)     Based on the $5.50 closing  price of the Company's  Common Stock on 
        December 31, 1996, as reported on the National Market tier of the 
        Nasdaq Stock Market, as reported  by the Wall  Street  Journal,  minus
        the  per-share  exercise  price, multiplied by the number of shares 
        underlying the option.
</FN>
</TABLE>


COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

       During 1996, the Company's  Compensation  Committee  consisted of Messrs.
Cable and Phelps,  both of whom were  nonemployee  directors.  To the  Company's
knowledge, no member of the Compensation Committee has a relationship that would
constitute an interlocking  relationship with executive officers or directors of
another entity.

       Mr. Cable is Chairman of the Board of Trustees of the Washington Research
Foundation  (the "WRF"),  a  not-for-profit  licensing  agency  dedicated to the
transfer to the private  sector of  technology  developed at the  University  of
Washington  (the  "University").  During the year ended  December 31, 1996,  the
Company  incurred  approximately  $154,000 in patent legal expenses on behalf of
the WRF in accordance with the Company's  worldwide exclusive license agreements
with the WRF for the urinary assay for measuring bone  resorption and osteoclast
colony stimulating factor technologies.


COMPENSATION COMMITTEE REPORT ON EXECUTIVE COMPENSATION

       The Compensation Committee of the Board of Directors (the "Committee") is
responsible for determining  the  compensation of the executive  officers of the
Company. The Committee is comprised of two nonemployee directors.  In making its
determinations,  the Committee relies on input from compensation consultants and
reviews  appropriate  decisions with all nonemployee  directors who constitute a
majority of the full Board of Directors.

       EXECUTIVE COMPENSATION  PHILOSOPHY.  The Company's executive compensation
program reflects the philosophy that executives' rewards should be structured to
closely  align  their  interests  with those of the  shareholders.  The  program
emphasizes  stock-based  incentives,  and  extends  these  concepts  beyond  the
executive  officer  population  to all  full-time  employees  in the interest of

<PAGE>

motivation,   teamwork,  and  fairness.  The  Company's  executive  compensation
programs  are  designed to attract  and retain  experienced  and well  qualified
executive  officers  who will enhance the  performance  of the Company and build
shareholder  value.  The  Company's  executive  compensation  program  generally
includes two components: base salary and stock options.

       In setting the compensation level for executive  officers,  the Committee
is guided by the following considerations:

       -  compensation levels should be competitive with compensation  generally
          being  paid  to  executives  in  the   biotechnology   and  diagnostic
          industries  to ensure the  Company's  ability  to  attract  and retain
          superior executives;
       -  a significant portion of executive officer compensation should be paid
          in the form of equity based incentives to link closely shareholder and
          executive  interests  and to  encourage  stock  ownership by executive
          officers; and
       -  each individual  executive  officer's  compensation should reflect the
          performance  of the  Company  as a whole  and the  performance  of the
          executive officer.

       BASE SALARY.  An executive  officer's  base salary is  determined  by the
Company's overall  performance,  the responsibility of the particular  position,
and   an   assessment   of   the   person's   performance   against   individual
responsibilities  and objectives,  including,  where appropriate,  the impact of
such performance on the business results of the Company.  The Committee also may
consider  nonfinancial  indicators  including,  but not  limited  to,  strategic
developments  for which an  executive  officer  has  responsibility,  intangible
elements  of  managerial  performance  and levels of  compensation  to  maintain
competitive  levels with similar  companies in the  biotechnology and diagnostic
industries.  Executive  officer  salaries are  generally  reviewed  annually and
adjusted each calendar year based upon these considerations.

       STOCK  OPTIONS.  Stock  options are a regular  component of the executive
compensation  program.  The Committee  sets  guidelines  for the number of stock
options  granted or shares awarded,  based on the Company's  performance and the
targeted value of each executive's overall compensation package. In setting such
guidelines,  the Committee evaluates the long-term incentive packages offered to
the Company's executives in relation to the long-term incentive packages offered
by other  biotechnology  companies  which the  Committee  considers to be in the
Company's  peer group.  These option grants  reflect the  Committee's  policy of
encouraging  long-term  performance  and  promoting  executive  retention  while
further aligning  management's and shareholders'  interest in the performance of
the Company's Common Stock.

       In 1996,  the Committee  granted an aggregate of 257,500 stock options to
seven executive officers of the Company as an incentive for future  performance,
including  options for  200,000  shares to Mr.  Glaser and 12,500  shares to Mr.
Strelke.

       EXECUTIVE  BENEFITS.  The Company offers the same benefits  package to
executive  officers as it does to all full-time employees of the Company.

       COMPENSATION OF THE CHIEF EXECUTIVE OFFICER.  Mr.  Cairncross' 1996 
compensation  consisted of a base salary of $250,000.

       In  April  1994,  Mr.  Cairncross  entered  into  an at  will  employment
agreement  with the  Company.  At that time,  an  initial  public  offering  was
contemplated  and was  ultimately  completed in February 1995. The Committee set
Mr.  Cairncross'  1994 base  salary at  $250,000,  to be  competitive  with base
salaries  paid to other  executives in the  biotechnology  industry with similar
responsibilities  and  seniority.  Mr.  Cairncross'  base  salary  has  remained
competitive and has not changed since 1994.

       COMPLIANCE WITH INTERNAL  REVENUE CODE SECTION 162(M).  Section 162(m) of
the Internal Revenue Code,  generally disallows a tax deduction to publicly-held
companies for annual  compensation  in excess of $1 million  earned by the chief
executive  officer or any of the other four highest  compensated  officers.  The
deduction limit does not apply,  however, to performance based compensation that
satisfies certain requirements.  Although the Committee has not yet determined a

<PAGE>

policy with respect to Section  162(m) and no officer of the Company is expected
to earn  compensation  in excess of $1 million in 1997 that would not qualify as
performance-based compensation, the Committee intends to review the implications
of Section 162(m) with respect to the Company's executive compensation policies.


                Compensation Committee of the Board of Directors
                ------------------------------------------------ 
                               Mr. Thomas J. Cable
                              Mr. Gregory D. Phelps


EMPLOYMENT, TERMINATION AND CHANGE OF CONTROL AGREEMENTS

       In  April  1994,  Mr.  Cairncross  entered  into  an at  will  employment
agreement  with the Company  which  provides  for an annual  salary of $250,000,
subject to  adjustment by the Board of Directors.  The  employment  agreement is
terminable at will by either party.

         The Company has entered into a consulting  agreement  with Dr. Eyre for
assistance  with the urinary assay for measuring bone  resorption and osteoclast
colony stimulating  factor  technologies which remains in effect at December 31,
1996. The agreement  provides for the payment of $6,000 per month by the Company
to Dr. Eyre, plus expenses. During the year ended December 31, 1996, the Company
paid Dr. Eyre $72,000 pursuant to the agreement.


                              CERTAIN TRANSACTIONS

         The  Company  has  entered  into  two  research   agreements  with  the
University of  Washington  extending  through March 31, 1999.  Pursuant to these
agreements,  the  Company  is  obligated  to fund  certain  research  activities
conducted by Dr. Eyre and one other research group at the University. During the
year ended  December 31, 1996,  the Company  paid the  University  approximately
$304,000  under these  agreements.  Dr. Eyre has been the Burgess  Professor  of
Orthopedics at the University since 1985.

         During the first  quarter 1996,  Mr. Glaser was Senior Vice  President,
Marketing,  U.S.  Human  Health of Merck and  Company,  Inc.  For the year ended
December 31, 1996, Merck and Merck affiliates purchased $379,000 of 
OSTEOMARK-Registered Trademark- kits from the Company.


<PAGE>


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

       The  following  table  sets  forth  certain  information   regarding  the
beneficial ownership of the Common Stock as of April 1, 1997, by (i) each person
who is known by the  Company  to own  beneficially  more  than 5% of the  Common
Stock;  (ii) each director and nominee for director;  (iii) each Named Executive
Officer;  and (iv) all  directors  and  executive  officers  of the Company as a
group.

<TABLE>
<CAPTION>
                                                NUMBER OF         PERCENTAGE BENEFICIALLY
NAME OF BENEFICIAL OWNER                        SHARES (1)               OWNED (2)
- --------------------------                      ----------               ---------
<S>                                              <C>                     <C> 
David R. Eyre, Ph.D. (3)                         1,448,500                11.64%
8011 East Mercer Way
Mercer Island, WA 98040

Thomas  J.  Cable  (4)                           1,029,236                 8.27%
c/o Cable & Howse Ventures
777  108th  Ave.  N.E.
Bellevue,   WA   98004

Wisconsin Investment Board                         839,000                 6.74%
P.O. Box 7842
Madison, WI  53707

Mochida Pharmaceutical, Co., Ltd.                  736,842                 5.92%
Y.S. Building
9 San-Eicho, Shinjuku-ku
Tokyo 160, Japan

H. Raymond Cairncross (5)                          678,500                 5.45%

Shaw Venture Partners                              642,935                 5.17%
400 S.W 6th Ave.
Suite 1100
Portland,   OR   97204

William K. Strelke (6)                              38,725                   *

Robert J. Glaser (7)                                 3,333                   *

Gregory D. Phelps (7)                                3,333                   *

Fredric J. Feldman                                   -                       -

Gilbert S. Omenn                                     -                       -

All directors and executive officers
as a group (twelve persons) (8)                  3,231,302                25.96%

- -------

*Less than 1%


<PAGE>

<FN>

(1)    This table is based upon  information  supplied  by  executive  officers,
       directors  and  principal  shareholders.  The  address  of  each  officer
       identified  in this  table is that of the  Company's  executive  offices.
       Unless otherwise  indicated in the footnotes to this table and subject to
       community property laws where applicable,  each of the shareholders named
       in this table has sole voting and  investment  power with  respect to the
       shares shown as beneficially owned.

(2)    Percentage of beneficial  ownership is based on 12,447,617  shares of 
       Common Stock  outstanding  as of April 1, 1997.

(3)    Includes  560,000  shares held in trust for the benefit of Dr. Eyre's  
       children and 37,500 shares subject to fully vested stock options.

(4)    Includes  991,070 shares held by CH Partners IV Limited  Partnership ("CH
       IV"), a venture  capital  fund of which Mr.  Cable is a general  partner.
       Under  federal   securities   laws,  Mr.  Cable  may  be  deemed  to  own
       beneficially all of the shares held by CH IV. In addition,  the number of
       shares   includes   6,666  shares  subject  to  stock  options  that  are
       exercisable within 60 days of April 1, 1997.

(5)    Includes 670,500 shares subject to stock options that are exercisable 
       within 60 days of April 1, 1997.

(6)    Includes 38,125 shares subject to stock options that are exercisable 
       within 60 days of April 1, 1997.

(7)    Represents shares subject to stock options that are exercisable within 
       60 days of April 1, 1997.

(8)    Includes 789,000 shares subject to stock options that are exercisable 
       within 60 days of April 1, 1997.
</FN>
</TABLE>


COMPLIANCE WITH SECTION 16(A) OF THE EXCHANGE ACT

         Section  16(a) of the  Securities  Exchange Act of 1934 (the  "Exchange
Act") requires the Company's  officers and  directors,  and persons who own more
than 10% of the  Common  Stock,  to file  reports  of  ownership  and  change in
ownership  with the  Securities  and  Exchange  Commission  ("SEC") and with the
National Association of Securities Dealers, Inc. Officers, directors and greater
than 10%  shareholders  are required by SEC  regulations  to furnish the Company
with copies of all Section 16(a) reports that they file.

         To the Company's knowledge, based solely on its review of the copies of
such reports furnished to the Company and written  representations that no other
reports were required,  all Section 16(a) filing requirements  applicable to its
officers,  directors  and greater than ten percent  shareholders  were  compiled
during the fiscal year ended December 31, 1996.




<PAGE>



                                PERFORMANCE GRAPH


 COMPARISON OF THE COMPANY'S CUMULATIVE TOTAL RETURN ON COMMON STOCK DURING THE
  PERIOD FROM JANUARY 25, 1995 (WHEN THE COMPANY'S STOCK BEGAN PUBLIC TRADING)
      TO DECEMBER 31, 1996 AMONG OSTEX INTERNATIONAL, INC., THE NASDAQ U.S.
            STOCK MARKET, AND THE HAMBRECHT & QUIST HEALTHCARE INDEX.


                     [PERFORMANCE GRAPHIC FILED SEPARATELY]


- ------------------------------------------------------------------------------
                     1/25/95  3/95  6/95  9/95  12/95  3/96  6/96  9/96  12/96
- ------------------------------------------------------------------------------
- ------------------------------------------------------------------------------
Ostex International,  100      99   245   236    203   168   111    84    58
Inc.
- ------------------------------------------------------------------------------
- ------------------------------------------------------------------------------
Nasdaq U.S. 
Stock Market          100    108    123   138    140   146   158    164   172
- ------------------------------------------------------------------------------
- ------------------------------------------------------------------------------
Hambrecht & Quist
Healthcare Index      100    109    117   144    166   169   159    172   171
- ------------------------------------------------------------------------------


The above graph  assumes  $100  invested in the Common  Stock,  the Nasdaq Stock
Market and the Hambrecht & Quist Healthcare Index with all dividends reinvested.
The Company has not paid cash dividends on its Common Stock.  Stock  performance
shown in the above graph for the Common Stock is historical and not  necessarily
indicative of future price performance.


                                   PROPOSAL 2:
                           AMENDMENT TO THE 1994 PLAN


         The Company's 1994 Plan was adopted by the Company's Board of Directors
in May  1994 and  approved  by the  Company's  shareholders  in June  1994 to be
effective  for a ten-year  period.  The  Company  reserved a total of  1,000,000
shares of Common Stock for issuance  under both the 1994 Plan and the  Company's
Directors Plan. The 1,000,000 shares reserved for issuance reflect the Company's
five-for-one stock split effected in the form of a stock dividend,  paid in June
1994.  As of April 1, 1997,  options to purchase an aggregate of 751,625  shares
had been  granted  under  the 1994  Plan and the  Directors  Plan.  The Board of
Directors  has  amended  the 1994 Plan to make it  separate  and apart  from the

<PAGE>

Directors  Plan and to  establish  a finite  number of  shares  of Common  Stock
reserved  for  issuance  under  the  1994  Plan.  At  the  Annual  Meeting,  the
shareholders  of the Company  will be asked to approve an  amendment to the 1994
Plan to increase the number of shares of Common Stock  authorized under the 1994
Plan to 1,750,000 shares.

         The  proposed  amendment  is designed  to help the Company  continue to
attract and retain the best  available  personnel for  positions of  substantial
responsibility,  and to provide an incentive to  officers,  employee  directors,
employees, consultants and advisors of the Company. Set forth below is a summary
description of the 1994 Plan, as recommended to the  shareholders for amendment,
and is qualified in its entirety by reference to the full text of the 1994 Plan,
a copy of which is available upon request from the Company.

DESCRIPTION OF THE 1994 PLAN

         Pursuant  to the  1994  Plan,  options  may be  granted  to  employees,
employee  directors,  consultants  and  advisors of the  Company.  The 1994 Plan
provides  for the  granting of both  incentive  stock  options  ("ISOs")  (stock
options that are intended to qualify for favorable  tax treatment  under Section
422 of the  Internal  Revenue  Code  of  1986,  as  amended  (the  "Code"))  and
nonqualified  stock  options  ("NSOs").  Options  granted  under  the 1994  Plan
generally become fully vested and exercisable four years from the date of grant,
with 25% of the total option  vesting on each  anniversary of the date of grant.
An  aggregate of 1,750,000  shares of Common  Stock is  authorized  for issuance
under the 1994 Plan, subject to adjustment from time to time for stock dividends
and certain other changes in  capitalization as provided in the 1994 Plan. As of
April 1, 1997, options for an aggregate of 711,625 shares had been granted under
the 1994 Plan, leaving 1,038,375 shares available for future issuance.

         The 1994  Plan may be  administered  by the  Board of  Directors,  or a
committee designated by the Board of Directors,  which shall have full power and
authority to administer  and interpret the 1994 Plan and to adopt,  from time to
time, such guidelines,  rules, regulations,  agreements, and instruments for the
administration  of the 1994 Plan as the Board of  Directors  deems  necessary or
advisable.  Currently,  the  1994  Plan  is  administered  by  the  Compensation
Committee of the Board of Directors.

         The Board of  Directors,  acting  through the  Compensation  Committee,
selects the  participants  to receive stock options and determines the number of
shares,  the type of grant,  the exercise price, as well as the time or times at
which options may be exercised and other terms and conditions of such grant. For
ISOs,  the  exercise  price  may not be less than the fair  market  value of the
Common Stock on the date of grant.  For NSOs, the option price may be less than,
equal to, or greater  than the fair market value of the Common Stock on the date
of grant. In the event of stock dividends,  splits, and similar capital changes,
the 1994 Plan  provides  for  appropriate  adjustments  in the  number of shares
available  for  options  and the number and option  prices of shares  subject to
outstanding options.

         The term of each option granted under the 1994 Plan may be no more than
ten years from the date of grant.  Options granted to employees  expire one year
following  termination  of  employment,  except  for ISOs  which  expire 90 days
following  termination of employment,  (but in neither event later than the date
of expiration  of the term of the option as set forth in the option  agreement),
and  except  in the  case of  permanent  disability  or  death.  In the  case of
termination of employment  due to permanent  disability or death of an employee,
the option  terminates one year from the date that the employee ceases work as a
result of the  employee's  disability  or death (but in no event  later than the
date of  expiration  of the  term of such  option  as set  forth  in the  option
agreement).  In addition,  for employees who have been continuously  employed by
the Company for a minimum of two years, regardless of the vesting schedule, upon
death or disability,  the option shall become fully vested and exercisable.  The
Board of Directors has the authority to extend the foregoing expiration dates of
any outstanding option in circumstances it deems  appropriate,  provided that it
may not extend an option  beyond the  original  term of such option  (e.g.,  ten
years from date of grant).

         The exercise  price of option shares may be paid in cash, by means of a
cash equivalent,  or in accordance with procedures for a "cashless  exercise" as
the same may be established from time to time by the Company and, if applicable,
a brokerage firm that the Company may retain to facilitate  exercises of options
and sales of shares under the 1994 Plan.  For NSOs,  the option holder must also
pay to the Company, at the time of purchase,  the amount of federal,  state, and
local  withholding  taxes required to be withheld by the Company.  Under certain

<PAGE>

limited  circumstances,  shares of Common  Stock may be used for  payment of the
option price or satisfaction of withholding obligations.

         In the event of a change of control  of the  Company,  any  outstanding
option  granted  under the 1994 Plan will become  fully  vested and  immediately
exercisable.  A "change of  control"  is defined  under the 1994 Plan as (i) the
acquisition  by any person of beneficial  ownership of 50% or more of the voting
power  of the  Company's  outstanding  securities  or (ii) the  occurrence  of a
transaction  requiring  shareholder  approval and  involving  the sale of all or
substantially all of the assets of the Company or the merger of the Company with
or into another corporation. In addition, upon the liquidation or dissolution of
the Company, all outstanding options shall terminate;  provided,  however,  that
prior to such  liquidation  or  dissolution,  an option  holder has the right to
exercise  his or her  options  in whole or in part  whether  or not the  vesting
requirements set forth in the option agreement have been satisfied.

         The options are  assignable  only (i) by will or by the laws of descent
and  distribution,  or (ii) in the case of an NSO, by gift to  immediate  family
members of the optionee,  partnership  of which the only partners are members of
the optionee's  immediate family,  and trusts established solely for the benefit
of such immediate family members.

         The 1994 Plan may be modified,  amended,  or terminated by the Board of
Directors  except  with  respect  to  options  granted  prior  to  such  action.
Notwithstanding  the  foregoing,   shareholder  approval  is  required  for  any
amendment  which  increases the number of shares subject to the 1994 Plan (other
than in connection with automatic  adjustments due to changes in  capitalization
or the  assumption  or  substitution  of options in  connection  with mergers or
acquisitions),  changes the persons  eligible  to receive  options,  or which is
otherwise  subject to shareholder  approval  pursuant to the federal  securities
laws or tax laws.

FEDERAL INCOME TAX CONSEQUENCES RELATING TO THE 1994 PLAN

         The 1994 Plan is not qualified  under Section 401(a) of the Code and is
not subject to the Employee Retirement Income Security Act of 1974.

         The federal income tax  consequences of an employee's  participation in
the 1994 Plan are complex and subject to change.  The following  discussion,  is
only a summary of the general rules applicable to options. Recipients of options
under the 1994 Plan should  consult  their own tax  advisors  since a taxpayer's
particular  situation may be such that some variation of the general rules would
apply.

         INCENTIVE STOCK OPTIONS

         If an option  granted  under the 1994 Plan is  treated  as an ISO,  the
optionee  will not recognize any income upon either the grant or the exercise of
the option and the  Company  will not be allowed a  deduction  for  federal  tax
purposes  with  respect  to such  grant or  exercise.  Upon a sale of the shares
received upon exercise of the option,  the tax treatment to the optionee and the
Company will depend  primarily upon whether the optionee has met certain holding
period  requirements  at the time he or she sells the shares.  In  addition,  as
discussed  below,  the  exercise of an  incentive  stock  option may subject the
optionee to alternative minimum tax liability.

         If an  optionee  exercises  an ISO and does not  dispose  of the shares
received  within two years after the date of the grant of such option and within
one year of the date of exercise,  any gain  realized upon  disposition  will be
characterized  as long-term  capital gain. In such case, the Company will not be
entitled to a federal tax deduction.

         If the optionee  disposes of the shares  either  within two years after
the date that the option is granted or within one year of the date of  exercise,
such  disposition  will be treated as a disqualifying  disposition and an amount
equal to the  lesser of (1) the fair  market  value of the shares on the date of
exercise minus the purchase price, or (2) the amount realized on the disposition
minus the purchase  price,  will be taxed as ordinary  income to the optionee in
the taxable year in which the  disposition  occurs.  The excess,  if any, of the
amount realized upon  disposition  over the fair market value at the time of the
exercise of the option will be treated as  long-term  capital gain if the shares
have been held for more than one year  following the exercise of the option.  In

<PAGE>

the event of a disqualifying disposition,  the Company may withhold income taxes
from the optionee's compensation with respect to the ordinary income realized by
the optionee as a result of the disqualifying disposition.

         The exercise of an ISO may subject an optionee to  alternative  minimum
tax  liability  because the excess of the fair market value of the shares at the
time an  incentive  stock option is  exercised  over the  purchase  price of the
shares is included in income for  purposes of the  alternative  minimum tax even
though it is not included in the taxable income for purposes of determining  the
regular tax liability of an incentive stock option recipient.  Consequently,  an
optionee may be obligated to pay  alternative  minimum tax in the year he or she
exercises an ISO.

         In general,  there will be no federal income tax deductions  allowed to
the Company upon the grant,  exercise, or termination of an ISO. However, in the
event an optionee  sells or disposes of stock  received  upon the exercise of an
ISO in a disqualifying disposition,  the Company will be entitled to a deduction
for federal  income tax purposes in an amount equal to the ordinary  income,  if
any,  recognized by the optionee upon  disposition of the shares,  provided that
the deduction is not otherwise disallowed under the Code.

         NONQUALIFIED STOCK OPTIONS

         NSOs  granted  under the 1994 Plan do not qualify as  "incentive  stock
options" and will not qualify for any special tax benefits to the  optionee.  An
optionee will not recognize any taxable  income at the time he or she is granted
an NSO. However, upon its exercise,  the optionee will recognize ordinary income
for federal tax purposes measured by the excess of the then fair market value of
the shares over the option exercise  price.  The income realized by the optionee
will be subject to income tax  withholding  by the  Company  out of the  current
earnings paid to the optionee. If such earnings are insufficient to pay the tax,
the  optionee  will be required to make a direct  payment to the Company for the
tax liability.

         The  optionee's  basis  for  determination  of gain or  loss  upon  the
subsequent  disposition  of shares  acquired upon the exercise of an NSO will be
the amount paid for such shares plus any ordinary income  recognized as a result
of the  exercise  of such  option.  Upon a  disposition  of any shares  acquired
pursuant to the  exercise of an NSO, the  difference  between the sale price and
the optionee's basis in the shares will be treated as a capital gain or loss and
will be characterized as long-term  capital gain or loss if the shares have been
held for more than one year at the date of their disposition.

         In general,  there will be no federal tax  consequences  to the Company
upon the grant or  termination  of an NSO or a sale or disposition of the shares
acquired upon the exercise of an NSO. However,  upon the exercise of an NSO, the
Company will be entitled to a deduction for federal income tax purposes equal to
the amount of ordinary  income that an  optionee is required to  recognize  as a
result of the exercise,  provided that the deduction is not otherwise disallowed
under the Code.

VOTE REQUIRED AND BOARD RECOMMENDATION

         The  affirmative  vote of the  holders of a  majority  of the shares of
Common Stock  represented  at the Annual Meeting is required for approval of the
amendment to the 1994 Plan.

         THE  BOARD  OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE  APPROVAL  OF THE
AMENDMENT TO THE COMPANY'S 1994 STOCK OPTION PLAN.



<PAGE>

                                   PROPOSAL 3:
                         AMENDMENT TO THE DIRECTORS PLAN

         The  Company's  Directors  Plan was adopted by the  Company's  Board of
Directors in May 1994 and approved by the Company's  shareholders  in June 1994.
The  Directors  Plan  provides  for  automatic  grants  of NSOs  to  nonemployee
directors of the Company upon  becoming a director at an exercise  price that is
equal to the fair  market  value  per share of the  Common  Stock on the date of
grant. In conjunction  with the adoption of the 1994 Plan, the Company  reserved
an aggregate of 1,000,000  shares of Common Stock for issuance  under both plans
(which shares  reserved for issuance  reflect the Company's  five-for-one  stock
split effected in the form of a stock dividend, paid in June 1994). The Board of
Directors has amended the Directors  Plan to make it separate and apart from the
1994 Plan and to establish a finite number of shares reserved for issuance under
the Directors Plan.

         In April 1997, the Company's Board of Directors unanimously approved an
amendment to the Directors Plan,  subject to shareholder  approval,  to increase
the total number of shares of Common Stock  authorized  under the Directors Plan
to 350,000  shares.  The  proposed  amendment  is  designed  to help the Company
continue to attract and retain the  services of  experienced  and  knowledgeable
outside  directors and to provide  additional  incentives  for such directors to
align their  proprietary  interests  with the  Company's  long-term  success and
progress.  Set forth below is a summary  description  of the Directors  Plan, as
recommended to the shareholders for amendment,  and is qualified in its entirety
by  reference  to the  full  text of the  Directors  Plan,  a copy of  which  is
available upon request from the Company.

DESCRIPTION OF THE DIRECTORS PLAN

         The Directors Plan provides for automatic grants of NSOs to nonemployee
directors of the Company at an exercise price equal to the fair market value per
share of the Common Stock on the date of grant.  Upon  becoming a director,  any
nonemployee  director  initially  elected or  appointed  will receive an initial
grant of options to purchase  25,000  shares of Common Stock.  Each  nonemployee
director  who has been in  office  for a period  of at least  five  months  will
automatically  receive an annual  grant of options to  purchase  10,000  shares,
effective as of the day following each annual meeting of  shareholders  at which
he  or  she  is  reelected  or  continues  as a  director.  Options  granted  to
nonemployee  directors become fully vested and exercisable  three years from the
date of grant, with one-third of the total option vesting on each anniversary of
the date of grant.  An aggregate of 350,000 shares of Common Stock is authorized
for issuance under the Directors  Plan,  subject to adjustment from time to time
for stock dividends and certain other changes in  capitalization  as provided in
the  Directors  Plan.  As of April 1, 1997,  options for an  aggregate of 40,000
shares had been  granted  under the  Directors  Plan to  nonemployee  directors,
leaving 310,000 shares available for future issuance.

         Options granted under the Directors Plan are nontransferable other than
by will or the laws of descent and  distribution  or, to the extent permitted by
Rule 16b-3 under the Exchange Act, to certain  family members and family trusts.
Options  expire 10 years  from the date of grant or 90 days  after a  director's
termination of service as a director, except in the case of death or disability,
in which case the options expire one year after termination.

         The administrator of the Directors Plan is the Board of Directors.  The
administrator has the power to construe the provisions of the Directors Plan, to
determine all questions  arising  thereunder,  and to adopt and amend such rules
and  regulations  for the  administration  of the Directors  Plan as it may deem
necessary or desirable.  No member of the Board of Directors may  participate in
any vote by the Board of Directors on any matter materially affecting the rights
of any such member under the Directors Plan.

         In the event of a change of control  of the  Company,  any  outstanding
option granted under the Directors Plan will become fully vested and immediately
exercisable.  A "change of control" is defined under the  Directors  Plan as (i)
the  acquisition  by any person of  beneficial  ownership  of 50% or more of the
voting power of the Company's outstanding securities or (ii) the occurrence of a
transaction  requiring  shareholder  approval and  involving  the sale of all or
substantially all of the assets of the Company or the merger of the Company with
or into another corporation. In addition, upon the liquidation or dissolution of

<PAGE>

the Company, all outstanding options shall terminate;  provided,  however,  that
prior to such  liquidation  or  dissolution,  an option  holder has the right to
exercise  his or her  options  in whole or in part  whether  or not the  vesting
requirements set forth in the option agreement have been satisfied.

         The exercise  price of option shares may be paid in cash, by means of a
cash equivalent,  or in accordance with procedures for a "cashless  exercise" as
the same may be established from time to time by the Company and, if applicable,
a brokerage firm that the Company may retain to facilitate  exercises of options
and sales of shares under the Directors Plan. The option holder must also pay to
the Company,  at the time of purchase,  the amount of federal,  state, and local
withholding taxes required to be withheld by the Company.  Under certain limited
circumstances,  shares of Common  Stock may be used for  payment  of the  option
price or satisfaction of withholding obligations.

         The Directors Plan may be modified, amended, or terminated by the Board
of  Directors  except  with  respect to options  granted  prior to such  action.
Notwithstanding  the  foregoing,   shareholder  approval  is  required  for  any
amendment  which  increases the number of shares  subject to the Directors  Plan
(other  than  in  connection  with  automatic  adjustments  due  to  changes  in
capitalization  or the assumption or  substitution of options in connection with
mergers or  acquisitions),  changes the persons eligible to receive options,  or
which is  otherwise  subject to  shareholder  approval  pursuant  to the federal
securities laws or tax laws.

FEDERAL INCOME TAX CONSEQUENCES

         There are no tax  consequences to the Company or the option holder upon
the grant of an option under the Directors Plan. Upon the exercise of an option,
the option holder recognizes ordinary income equal to the difference between the
exercise  price for the shares of Common  Stock and the fair market value of the
shares on the date of exercise.  The Company is entitled to a corresponding  tax
deduction  equal to the amount of income  recognized by the optionee at the time
of recognition by the option holder.

VOTE REQUIRED AND BOARD RECOMMENDATION

         The  affirmative  vote of the  holders of a  majority  of the shares of
Common Stock  represented  at the Annual Meeting is required for approval of the
amendment to the Directors Plan.

         THE  BOARD  OF  DIRECTORS  RECOMMENDS  A VOTE FOR THE  APPROVAL  OF THE
AMENDMENTS TO THE DIRECTORS PLAN.


                                   PROPOSAL 4:
                      RATIFICATION OF SELECTION OF AUDITORS


         The  Board  of  Directors  has  selected  Arthur  Andersen  LLP  as the
Company's  independent  auditors for the year ending  December 31, 1997, and has
further  directed that management  submit the selection of independent  auditors
for ratification by the shareholders at the Annual Meeting.  Arthur Andersen LLP
has audited the Company's financial  statements since the Company's inception in
1989.  Representatives  of Arthur Andersen LLP are expected to be present at the
Annual  Meeting  and will have an  opportunity  to make a  statement  if they so
desire and will be available to respond to appropriate questions.

         Shareholder ratification of the selection of Arthur Andersen LLP as the
Company's  independent  auditors  is not  required  by the  Company's  Bylaws or
otherwise. However, the Board of Directors is submitting the selection of Arthur
Andersen LLP to the  shareholders for ratification as a matter of good corporate
practice.  If the  shareholders  fail to  ratify  the  selection,  the  Board of
Directors  will  reconsider  whether  or not to retain  that  firm.  Even if the
selection is ratified,  the Board of Directors in its  discretion may direct the
appointment of a different  independent  accounting  firm at any time during the
year if the Board of  Directors  determines  that such a change  would be in the
best interests of the Company and its shareholders.

<PAGE>

         The affirmative vote of the holders of a majority of the shares present
in person or  represented  by proxy and  entitled to vote at the meeting will be
required to ratify the selection of Arthur Andersen LLP.

         THE BOARD OF DIRECTORS  RECOMMENDS A VOTE FOR THE  RATIFICATION  OF THE
SELECTION OF ARTHUR ANDERSEN LLP AS INDEPENDENT AUDITORS OF THE COMPANY.


                            PROPOSALS OF SHAREHOLDERS

         Shareholder  proposals  to be presented  at the  Company's  1998 Annual
Meeting of Shareholders  and included in the Company's Proxy Statement  relating
to such  meeting must be received by the Company no later than January 31, 1998.
Such proposals should be directed to the Secretary of the Company,  2203 Airport
Way South, Suite 400, Seattle, Washington 98134.

                                 OTHER BUSINESS

         The Board of  Directors  does not  intend  to bring any other  business
before  the Annual  Meeting,  nor is the Board  aware of any other  matter to be
brought before the Annual  Meeting,  except as specified in the Notice of Annual
Meeting of  Shareholders.  However,  as to any other  business that may properly
come  before  the Annual  Meeting,  it is  intended  that  proxies,  in the form
enclosed,  will be voted in respect thereto,  in accordance with the judgment of
the persons voting such proxies.


                                  ANNUAL REPORT

         A copy of the Company's 1996 Annual Report to Shareholders is enclosed.
Shareholders  not receiving a copy of such annual report may obtain one, without
charge,  upon request to the  Company's  Investor  Relations at 2203 Airport Way
South, Suite 400, Seattle, Washington 98134.

                                By Order of the Board of Directors


                                /S/ JEFFREY J. MILLER

                                Jeffrey J. Miller
                                SECRETARY

Seattle, Washington
April 23, 1997





                            OSTEX INTERNATIONAL, INC.

         AMENDED AND RESTATED DIRECTORS' NONQUALIFIED STOCK OPTION PLAN

         This Nonqualified Stock Option Plan (the "Plan") provides for the grant
of options  to  acquire  shares of Common  Stock,  $.01 par value  (the  "Common
Stock"), of Ostex International, Inc., a Washington corporation (the "Company").

         1.       PURPOSE.  The purpose of this Plan is to compensate certain 
directors of the Company (the "Optionees" or "Optionee").

         2.  ELIGIBILITY.  Persons  eligible to receive  options under this Plan
shall be all  directors  of the  Company who are not  otherwise  employed by the
Company or any  Related  Corporation,  as  defined  below  (the  "Directors"  or
"Director").  Options may be granted in substitution for outstanding  Options of
another corporation in connection with the merger, consolidation, acquisition of
property or stock or other reorganization between such other corporation and the
Company  or any  subsidiary  of the  Company.  Options  also may be  granted  in
exchange for outstanding Options.

         As used in this Plan, the term "Related Corporation," when referring to
a subsidiary corporation, shall mean any corporation (other than the Company) in
an unbroken chain of corporations  beginning with the Company if, at the time of
the  granting  of the  Option,  each of the  corporations  other  than  the last
corporation in the unbroken chain owns stock  possessing  fifty percent (50%) or
more of the total  combined  voting  power of all classes of stock of one of the
other  corporations in such chain. When referring to a parent  corporation,  the
term "Related  Corporation"  shall mean any corporation (other than the Company)
in an unbroken chain of corporations  ending with the Company if, at the time of
granting of the Option,  each of the  corporations  other than the Company  owns
stock  possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock of one of the other corporations in such chain.

         3. STOCK.. Options to purchase an aggregate of 350,000 shares of Common
Stock (subject to adjustment as provided in Section 4.12) may be issued pursuant
to the Plan. As of the date that a person is initially elected or appointed as a
Director,  the  Company  shall  automatically  grant to such  person  options to
purchase 25,000 shares of the Company's authorized but unissued,  or reacquired,
Common Stock (subject to adjustment as provided in Section  4.12).  In addition,
for each  Director  who is in office the day  following  any  annual  meeting of
shareholders  of the Company (at which meeting such  Director was  re-elected or
continued  in office) and who has been in office for at least five months  prior
to such annual meeting, the Company will automatically grant options to purchase
10,000  shares of Common  Stock  (subject to  adjustment  as provided in Section
4.12). In the event that any outstanding Option expires or is terminated for any
reason,  those shares of Common Stock  allocable to the  unexercised  portion of
such Option may be subject to one or more other Options  issued  pursuant to the
Plan.

         4.       TERMS AND CONDITIONS OF OPTIONS.  Each Option shall be 
evidenced by a written  agreement (the "Agreement") in the form approved by
the Company. Agreements may contain such additional provisions, not inconsistent
herewith, as the Company in its discretion may deem advisable. All Options shall
also comply with the following requirements:

                  4.1      NUMBER OF SHARES.  Each Agreement shall state the 
number of shares to which it pertains.

                  4.2  DATE OF  GRANT.  Each  Option  shall  state  the date the
Company and the Director entered into the Agreement (the "Date of Grant"), which
shall be (i) in the case of new  Directors,  the date the  individual  becomes a
Director,  or (ii) the case of  Directors  in office  the day  after any  annual
meeting of shareholders, the date after such meeting whichever is applicable.

                  4.3 OPTION PRICE.  The exercise price for all Options  granted
hereunder  shall be the fair  market  value on Date of Grant.  Such fair  market
value shall be the closing price at which it was traded on a national securities
exchange or the last sale price quoted on the National Association of Securities
Dealers  Automated  Quotation System or any successor or  substantially  similar
market thereto on the Date of Grant. If the Common Stock shall be traded on more
than one such market, the exercise price shall be determined on the basis of the
most  active  market.  If no such market  exists,  the  exercise  price shall be
established  at  fair  market  value  based  on  the  most  recent   arms-length
transaction occurring within eighteen (18) months preceding the Date of Grant by
or among the Company or any greater-than-ten-percent ( >10%) shareholders of the
Company or, if unavailable, by a qualified appraiser selected by the Company.

                  4.4      VESTING SCHEDULE.  All Options shall vest according 
to the following schedule:

                                          Percentage of
            Number of Years              Total Option to
         FOLLOWING DATE OF GRANT          BE EXERCISABLE

                  1                          33 1/3%
                  2                          33 1/3%
                  3                          33 1/3%


                  4.5  ACCELERATION OF VESTING.  Options granted pursuant to the
Plan shall become  immediately  vested and fully exercisable upon the Director's
termination  as a director of the  Company by reason of the death or  Disability
(as defined in Section 4.6 below) of the Director.  The vesting of Options shall
also be accelerated under the circumstances  described in Sections 4.12 and 4.13
below.

                  4.6      TERMINATION OF OPTION.  A vested Option shall 
terminate, to the extent not previously exercised, upon the occurrence of the 
first of the following events:

                           (i)      ten (10) years from the Date of Grant;

                           (ii) the expiration of ninety (90) days from the date
         of Optionee's  termination  as a Director of the Company for any reason
         other than death or Disability (as defined below); or

                           (iii) the expiration of one (1) year from the date of
         death of Optionee or the cessation of Optionee's  service as a Director
         by reason of Disability (as defined below).

         "Disability"  shall  mean  that a person  is  unable  to  engage in any
substantial gainful activity by reason of any medically determinable physical or
mental  impairment that can be expected to result in death or that has lasted or
can be  expected  to last for a  continuous  period of not less than twelve (12)
months.  If Optionee's  service as a Director is terminated by death, any Option
held by Optionee shall be exercisable only by the person or persons to whom such
Optionee's rights under such Option shall pass by Optionee's will or by the laws
of descent and  distribution  of the state or country of Optionee's  domicile at
the time of death.  Each unvested Option granted pursuant hereto shall terminate
upon Optionee's  termination as a Director for any reason whatsoever,  including
death or Disability.

                  4.7 EXERCISE OF OPTIONS. Options shall be exercisable,  either
all or in part,  at any  time  after  vesting.  If less  than all of the  shares
included in the vested portion of any Option are purchased, the remainder may he
purchased at any subsequent  time prior to the expiration of the Option term. No
portion  of any  Option  of less than one (1) share  (as  adjusted  pursuant  to
Section 4.12 hereof) may be exercised;  PROVIDED,  that if the vested portion of
any Option is less than fifty (50) shares,  it may be exercised  with respect to
all shares for which it is vested.  Only whole shares may be issued  pursuant to
an Option,  and to the extent that an Option  covers less than one share,  it is
unexercisable.  Options or portions  thereof may be  exercised  by giving to the
Company an executed  notice of election to exercise,  which notice shall specify
the  number of shares to be  purchased,  and be  accompanied  by  payment in the
amount of the  aggregate  option price for the Common Stock so purchased  and in
the form  specified in Section 4.8 below.  The Company shall not be obligated to
issue,  transfer or deliver a certificate of Common Stock to any Director, or to
his personal representative,  until the aggregate option price has been paid for
all shares for which the Option shall have been exercised and adequate provision
has  been  made by the  Optionee  for the  satisfaction  of any tax  withholding
obligations  associated with such exercise.  During the lifetime of an Optionee,
Options are exercisable only by Optionee.

                  4.8  PAYMENT  UPON  EXERCISE OF OPTION.  Upon  exercise of any
option,  the  aggregate  option price shall be paid to the Company in cash or by
certified or cashier's check.  Alternatively,  a Director may pay for all or any
portion of the aggregate  option exercise price (i) by delivering to the Company
shares of Common Stock  previously  held by such  Director,  (ii) having  shares
withheld  from the  amount  of  shares of  Common  Stock to be  received  by the
Director or (iii) delivering an irrevocable  subscription  agreement  obligating
the  Director  to take and pay for the  shares of common  Stock to be  purchased
within one (1) year of the date of exercise. The shares of Common Stock received
or withheld by the Company as payment for shares of Common Stock  purchased upon
the  exercise of Options  shall have a fair market value at the date of exercise
(as  determined  in  accordance  with  Section 4.3 above equal to the  aggregate
option  exercise  price (or  portion  thereof) to be paid by the  Director  upon
exercise.

                  4.9 RIGHTS AS A SHAREHOLDER.  An Optionee shall have no rights
as a  shareholder  with  respect to any shares  covered by the Option until such
Optionee  becomes a record holder of such shares,  irrespective  of whether such
Optionee  has given notice of exercise.  Subject to the  provisions  of Sections
4.12 and 4.13 below,  no rights shall  accrue to an Optionee and no  adjustments
shall be made on account of  dividends  (ordinary or  extraordinary,  whether in
cash,  securities or other property) or  distributions  or other rights declared
on, or created  in, the Common  Stock for which the record  date is prior to the
date the Optionee  becomes a record holder of the shares of Common Stock covered
by the  Option,  irrespective  of  whether  such  Optionee  has given  notice of
exercise.

                  4.10 TRANSFER OF OPTION.  Options  granted under this Plan and
the  rights  and  privileges  conferred  by this  Plan  may not be  transferred,
assigned,  pledged or hypothecated in any manner (whether by operation of law or
otherwise) other than by will or by applicable laws of descent and distribution,
as defined by the Code, or the Employee  Retirement  Income Security Act, or the
rules  and  regulations  thereunder,  and  shall not be  subject  to  execution,
attachment or similar  process.  Upon any attempt to transfer,  assign,  pledge,
hypothecate  or  otherwise  dispose of any  Option or of any right or  privilege
conferred by this Plan contrary to the provisions hereof, or upon the sale, levy
or any attachment or similar process upon the rights and privileges conferred by
this Plan, such Option shall thereupon terminate and become null and void.

                  4.11     SECURITIES REGULATION AND TAX WITHHOLDING.

                           4.11.1   Shares shall not be issued with respect to 
an Option  unless the exercise of such Option and the issuance and delivery
of such shares  shall  comply with all relevant  provisions  of law,  including,
without limitation,  any applicable state securities laws, the Securities Act of
1933, as amended, the Securities Exchange Act of 1934, as amended, the rules and
regulations  thereunder  and the  requirements  of any stock exchange upon which
such shares may then be listed,  and such issuance  shall be further  subject to
the  approval  of counsel  for the  Company  with  respect  to such  compliance,
including the  availability of an exemption from  registration  for the issuance
and sale of such  shares.  The  inability  of the  Company  to  obtain  from any
regulatory  body the  authority  deemed by the Company to be  necessary  for the
lawful issuance and sale of any shares under this Plan, or the unavailability of
an  exemption  from  registration  for the issuance and sale of any shares under
this Plan,  shall  relieve  the  Company of any  liability  with  respect to the
non-issuance or sale of such shares.

         As a condition  to the  exercise of an Option,  the Company may require
the  Optionee to represent  and warrant in writing at the time of such  exercise
that the  shares  are  being  purchased  only for  investment  and  without  any
then-present  intention to sell or distribute such shares.  At the option of the
Company,  a  stop-transfer  order against such shares may be placed on the stock
books and records of the Company, and a legend indicating that the stock may not
be  pledged,  sold or  otherwise  transferred  unless an  opinion  of counsel is
provided stating that such transfer is not in violation of any applicable law or
regulation, may be stamped on the certificates representing such shares in order
to assure an  exemption  from  registration.  The Company  also may require such
other documentation as may from time to time be necessary to comply with federal
and  state   securities  laws.  THE  COMPANY  HAS  NO  OBLIGATION  TO  UNDERTAKE
REGISTRATION  OF OPTIONS OR THE SHARES OF STOCK  ISSUABLE  UPON THE  EXERCISE OF
OPTIONS.

                           4.11.2   As a condition to the exercise of any Option
granted under this Plan, the Optionee shall make such  arrangements  as the
Company  may  require  for the  satisfaction  of any  federal,  state  or  local
withholding tax obligations that may arise in connection with such exercise.

                           4.11.3   The issuance, transfer or delivery of 
certificates  of Common  Stock  pursuant to the  exercise of Options may be
delayed, at the discretion of the Board, until the Company is satisfied that the
applicable  requirements  of the  federal  and  state  securities  laws  and the
withholding provisions of the Code have been met.

                  4.12     STOCK DIVIDEND, REORGANIZATION OR LIQUIDATION.

                           4.12.1   If (i) the Company shall at any time be 
involved in a transaction  described in Section  424(a) of the Code (or any
successor provision) or any "corporate transaction" described in the regulations
thereunder;  (ii) the  Company  shall  declare a dividend  payable  in, or shall
subdivide  or  combine,   its  Common  Stock  or  (iii)  any  other  event  with
substantially  the same effect shall occur, the number of shares of Common Stock
and/or  the  exercise  price  per  share  of each  outstanding  Option  shall be
proportionately   adjusted  so  as  to  preserve  the  rights  of  the  Optionee
substantially  proportionate  to the rights of the Optionee prior to such event,
and to the extent that such action shall  include an increase or decrease in the
number of shares of Common Stock subject to outstanding  Options,  the number of
shares  available under Section 4 of this Plan shall  automatically be increased
or decreased, as the case may be, proportionately, without further action on the
part of the Company or the Company's shareholders.

                           4.12.2   If the Company is liquidated or dissolved, 
the holders of any outstanding  Options may exercise all or any part of the
unvested portion of the Options held by them;  PROVIDED,  that such Options must
be exercised prior to the effective date of such liquidation or dissolution.  If
the Option holders do not exercise  their Options prior to such effective  date,
each  outstanding  Option  shall  terminate  as of  the  effective  date  of the
liquidation or dissolution.

                           4.12.3   The grant of an Option shall not affect in 
any  way  the  right  or  power  of  the   Company  to  make   adjustments,
reclassifications,  reorganizations  or  changes  of  its  capital  or  business
structure,  to  merge,  consolidate  or  dissolve,  to  liquidate  or to sell or
transfer all or any part of its business or assets.

                  4.13 CHANGE IN CONTROL; DECLARATION OF EXTRAORDINARY DIVIDEND.

                           4.13.1   CHANGE IN CONTROL.  If at any time there 
is a Change in Control (as defined below) of the Company, all Options shall
accelerate and become fully vested and immediately  exercisable for the duration
of the Option term. For purposes of this Subsection 4.13.1,  "Change in Control"
shall mean either one of the  following:  (i) When any "person," as such term is
used in sections  13(d) and 14(d) of the Exchange Act (other than a  shareholder
of the  Company  on the date of this  Plan,  the  Company,  a  Subsidiary  or an
employee benefit plan of the Company,  including any trustee of such plan acting
as trustee)  becomes,  after the date of this Plan, the  "beneficial  owner" (as
defined in Rule 13d-3  under the  Exchange  Act),  directly  or  indirectly,  of
securities  of the  Company  representing  fifty  percent  (50%)  or more of the
combined voting power of the Company's then outstanding securities;  or (ii) the
occurrence of a transaction requiring  shareholder  approval,  and involving the
sale of all or  substantially  all of the assets of the Company or the merger of
the Company with or into another corporation.

                           4.13.2   DECLARATION OF EXTRAORDINARY DIVIDEND.  If 
at any time the Company  declares  an  Extraordinary  Dividend  (as defined
below),  all Options  shall  accelerate  and  thereupon  become fully vested and
immediately  exercisable  for the duration of the Option  term.  For purposes of
this  Subsection  4.13.2,  "Extraordinary  Dividend"  shall mean a cash dividend
payable to  holders of record of the Common  Stock in an amount in excess of ten
percent (10%) of the then fair market value of the Company's  Common Stock.  The
fair market  value of the  Company's  Common Stock shall be  determined  in good
faith by the Board.

         5.  EFFECTIVE  DATE;  TERM.   Subject  to  approval  of  this  Plan  by
shareholders  of the Company,  this Plan shall be effective as of the date which
is the first Date of Grant  specified  in Section 4.2 above,  and Options may be
issued then and from time to time  thereafter  until this Plan is  terminated by
the Company.  Termination  of this Plan shall not terminate  any Option  granted
prior to such termination.

         6.       NO OBLIGATIONS TO EXERCISE OPTION.  The granting of an Option
shall impose no obligation upon the Optionee to exercise such Option.

         7.       APPLICATION OF FUNDS.  The proceeds received by the Company 
from the sale of Common Stock, pursuant to the exercise of Options granted 
hereunder, will be used for general corporate purposes.

         8.  INDEMNIFICATION  OF  BOARD.  In  addition  to all  other  rights or
indemnification  they may have as  directors of the Company or as members of the
Board,  members  of the  Board  shall  be  indemnified  by the  Company  for all
reasonable expenses and liabilities of any type and nature, including reasonable
attorneys fees,  incurred in connection  with any action,  suit or proceeding to
which they or any of them are a party by reason of, or in connection  with,  the
Plan or any Option  granted  hereunder,  and against all amounts paid by them in
settlement  thereof  (provided such settlement is approved by independent  legal
counsel selected by the Company), except to the extent that such expenses relate
to  matters  for which it is  adjudged  that such Board  members  are liable for
willful  misconduct;   PROVIDED,   that  within  fifteen  (15)  days  after  the
institution  of any such  action,  suit or  proceeding,  member(s)  of the Board
shall,  in writing,  notify the Company of such action,  suit or proceeding,  so
that the Company may have the  opportunity to make  appropriate  arrangements to
prosecute or defend the same.

         9.  AMENDMENT OF PLAN. The Company may, at any time,  modify,  amend or
terminate  this Plan and Options  granted  under this Plan,  including,  without
limitation,  such  modifications  or  amendments  as are  necessary  to maintain
compliance with applicable  statutes,  rules or regulations;  PROVIDED,  that no
amendment with respect to an outstanding Option shall be made over the objection
of the Optionee  thereof and  PROVIDED  FURTHER,  that:  (i) the approval of the
holders of a majority  of the  Company's  outstanding  shares of voting  capital
stock  represented at a meeting at which a quorum is present is required  within
twelve (12) months  before or after the  adoption by the Board of any  amendment
that will permit the granting of Options to a class of persons  other than those
currently  eligible to receive  Options under this Plan or that would cause this
Plan to no longer comply with Securities and Exchange  Commission Rule 16b-3, as
amended,  or any successor rule or other  regulatory  requirements and (ii) this
Plan shall not be amended  more than once  every six (6)  months,  other than to
comport with changes in the Code, the Employee  Retirement  Security Act, or the
rules thereunder.






                            OSTEX INTERNATIONAL, INC.

                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN


         This 1994 Stock  Option  Plan (the  "Plan")  provides  for the grant of
options to acquire shares of Common Stock,  $.01 par value (the "Common Stock"),
of Ostex International,  Inc., a Washington  corporation (the "Company").  Stock
options  granted  under this Plan that qualify under Section 422 of the Internal
Revenue Code of 1986, as amended (the  "Code"),  are referred to in this Plan as
"Incentive Stock Options." Incentive Stock Options and stock options that do not
qualify under Section 422 of the Code  ("Non-Qualified  Stock Options")  granted
under this Plan are referred to as "Options."

         1.  PURPOSES.  The  purposes of this Plan are to retain the services of
valued key employees and  consultants of the Company,  and such other persons as
the Plan  Administrator  shall select in  accordance  with  Section 3 below,  to
encourage such persons to acquire a greater proprietary interest in the Company,
thereby   strengthening  their  incentive  to  achieve  the  objectives  of  the
shareholders of the Company, and to serve as an aid and inducement in the hiring
of  new  employees,   consultants  and  other  persons   selected  by  the  Plan
Administrator.

         2.  ADMINISTRATION.  This Plan  shall be  administered  by the Board of
Directors  of the  Company  (the  "Board"),  except  that the Board may,  in its
discretion,  establish  a  committee  composed  of members of the Board or other
persons to administer  this Plan,  which committee (the  "Committee")  may be an
executive,  compensation  or other  committee,  including  a separate  committee
especially created for this purpose. The Committee shall have such of the powers
and  authority  vested in the Board  hereunder  as the Board may  delegate to it
(including the power and authority to interpret any provision of this Plan or of
any Option).  The members of any such Committee shall serve at the discretion of
the Board. The Board, or the Committee if one has been established by the Board,
are referred to in this Plan as the "Plan Administrator." Following registration
of any of the Company's  securities under Section 12 of the Securities  Exchange
Act of 1934, as amended (the "Exchange  Act"), no person shall serve as a member
of the Plan  Administrator if his or her service would disqualify this Plan from
eligibility under Securities and Exchange Commission Rule 16b-3, as amended from
time to time, or any successor rule or regulatory  requirements;  PROVIDED, that
the Plan  Administrator  shall consist of at least the minimum number of persons
required by Securities and Exchange  Commission Rule 16b-3,  as amended,  or any
successor rule or regulatory requirements. If, and so long as, the Company has a
class of equity securities  registered under Section 12 of the Exchange Act, the
Board of Directors in determining  the  membership of any such committee  shall,
with  respect  to option  grants to any  persons  subject to or likely to become
subject  to  Section  16 of the  Exchange  Act,  give due  consideration  to the
provisions  regarding (a) "outside  directors" as contemplated by Section 162(m)
of the Code and (b) "nonemployee  directors" as contemplated by Rule 16b-3 under
the Exchange Act.

         Subject to the  provisions  of this Plan,  and with a view to effecting
its purpose,  the Plan Administrator shall have sole authority,  in its absolute
discretion,  to: (a) construe and interpret this Plan; (b) define the terms used
in this Plan; (c) prescribe, amend and rescind rules and regulations relating to
this Plan;  (d)  correct  any  defect,  supply any  omission  or  reconcile  any
inconsistency  in this Plan; (e) determine the individuals to whom Options shall
be granted  under this Plan and whether the Option is an Incentive  Stock Option
or a  Non-Qualified  Stock  Option;  (f)  determine  the  time or times at which
Options shall be granted under this Plan;  (g) determine the number of shares of
Common Stock  subject to each Option,  the  exercise  price of each Option,  the
duration  of each  Option  and the  times  at which  each  Option  shall  become
exercisable;  (h) determine all other terms and  conditions of Options;  and (i)
make all other  determinations  necessary or advisable for the administration of
this Plan. All decisions,  determinations and  interpretations  made by the Plan
Administrator  shall be binding and conclusive on all  participants in this Plan
and on their legal representatives, heirs and beneficiaries.

         3.  ELIGIBILITY.   Incentive  Stock  Options  may  be  granted  to  any
individual who, at the time the Option is granted, is an employee of the Company
or any Related  Corporation  (as defined  below),  including  employees  who are
directors  of the  Company  ("Employees").  Non-Qualified  Stock  Options may be
granted to Employees and to such other persons other than  directors who are not
Employees  as the Plan  Administrator  shall  select.  Options may be granted in
substitution for outstanding  Options of another  corporation in connection with
the  merger,   consolidation,   acquisition   of  property  or  stock  or  other
reorganization  between such other corporation and the Company or any subsidiary
of the Company. Options also may be granted in exchange for outstanding Options.
Any person to whom an Option is granted  under  this Plan is  referred  to as an
"Optionee."

         As used in this Plan, the term "Related Corporation," when referring to
a subsidiary corporation, shall mean any corporation (other than the Company) in
an unbroken chain of corporations  beginning with the Company if, at the time of
the  granting  of the  Option,  each of the  corporations  other  than  the last
corporation in the unbroken chain owns stock  possessing  fifty percent (50%) or
more of the total  combined  voting  power of all classes of stock of one of the
other  corporations in such chain. When referring to a parent  corporation,  the
term "Related  Corporation"  shall mean any corporation (other than the Company)
in an unbroken chain of corporations  ending with the Company if, at the time of
granting of the Option,  each of the  corporations  other than the Company  owns
stock  possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock of one of the other corporations in such chain.

         4.  STOCK.  Subject  to  approval  of the Plan by  shareholders  of the
Company,  options to  purchase a maximum of  1,750,000  shares of the  Company's
authorized but unissued, or required, Common Stock may be issued pursuant to the
Plan, subject to adjustment as provided in Section 5.13(a) below; PROVIDED, that
any shares of Common  Stock  received  or withheld by the Company as payment for
shares of Common Stock  purchased  upon exercise of Options  pursuant to Section
5.9 below shall be added to the number of such shares as to which Options may be
granted.  The  number of shares  with  respect to which  Options  may be granted
hereunder is subject to  adjustment  as set forth in Section 5.13 below.  In the
event that any outstanding  Option expires or is terminated for any reason,  the
shares of Common Stock allocable to the  unexercised  portion of such Option may
again be  subject to an Option to the same  Optionee  or to a  different  person
eligible under Section 3 above.

         5. TERMS AND CONDITIONS OF OPTIONS. Each Option granted under this Plan
shall be evidenced  by a written  agreement  approved by the Plan  Administrator
(the  "Agreement").  Agreements  may contain  such  additional  provisions,  not
inconsistent  with this Plan, as the Plan  Administrator  in its  discretion may
deem advisable. All Options also shall comply with the following requirements:

                  5.1 NUMBER OF SHARES AND TYPE OF OPTION.  Each Agreement shall
state the number of shares of Common  Stock to which it pertains and whether the
Option is intended to be an  Incentive  Stock  Option or a  Non-Qualified  Stock
Option.  In the absence of action to the contrary by the Plan  Administrator  in
connection with the grant of an Option, all Options shall be Non-Qualified Stock
Options.  The aggregate fair market value  (determined at the Date of Grant,  as
defined  below) of the stock with respect to which  Incentive  Stock Options are
exercisable for the first time by the Optionee during any calendar year (granted
under this Plan and all other  Incentive  Stock Option  plans of the Company,  a
Related Corporation or a predecessor corporation) shall not exceed such limit as
may be prescribed by the Code as it may be amended from time to time. Any Option
which  exceeds  the  annual  limit  shall  not be void  but  rather  shall  be a
Non-Qualified Stock Option.

                          (a) LIMITATION ON NUMBER OF SHARES UNDERLYING OPTIONS.
Subject to adjustment  from time to time as provided in Section 5.13 below,
the Plan  Administrator  shall not grant options to any person in any one fiscal
year of the Company in an amount that exceeds, in the aggregate,  200,000 shares
of Common Stock.  This limitation  shall be applied in a manner  consistent with
the  requirements  of, and only to the extent required for compliance  with, the
exclusion from the limitation on  deductibility  of  compensation  under Section
162(m) of the Code.

                  5.2 DATE OF GRANT.  Each  Agreement  shall  state the date the
Plan  Administrator  has  deemed  to be the  effective  date of the  Option  for
purposes of this Plan (the "Date of Grant").

                  5.3 OPTION  PRICE.  Each  Agreement  shall state the price per
share of Common Stock at which it is  exercisable.  The exercise  price shall be
fixed by the Plan  Administrator  at whatever price the Plan  Administrator  may
determine in the exercise of its sole discretion;  PROVIDED,  that the per share
exercise  price  for  any  Option  granted   following  the  effective  date  of
registration  of  any  of  the  Company's  securities  under  Section  12 of the
Securities Exchange Act of 1934 shall not be less than the fair market value per
share  of the  Common  Stock at the  Date of  Grant  as  determined  by the Plan
Administrator in good faith; PROVIDED FURTHER, that the per share exercise price
for an  Incentive  Stock Option shall not be less than the fair market value per
share  of the  Common  Stock at the  Date of  Grant  as  determined  by the Plan
Administrator in good faith;  PROVIDED  FURTHER,  that with respect to Incentive
Stock Options  granted to  greater-than-ten  percent ( >10%) shareholders of the
Company  (as  determined  with  reference  to Section  424(d) of the Code),  the
exercise  price per share shall not be less than one hundred ten percent  (110%)
of the fair  market  value per share of the  Common  Stock at the Date of Grant;
and, PROVIDED FURTHER,  that Incentive Stock Options granted in substitution for
outstanding  Options of  another  corporation  in  connection  with the  merger,
consolidation,   acquisition  of  property  or  stock  or  other  reorganization
involving  such  other  corporation  and the  Company or any  subsidiary  of the
Company may be granted with an exercise  price equal to the  exercise  price for
the  substituted  Option of the other  corporation,  subject  to any  adjustment
consistent with the terms of the transaction  pursuant to which the substitution
is to occur.

                  5.4  DURATION  OF  OPTIONS.  At the  time of the  grant of the
Option,  the Plan Administrator  shall designate,  subject to Section 5.7 below,
the expiration  date of the Option,  which date shall not be later than ten (10)
years from the Date of Grant in the case of Incentive  Stock Options;  PROVIDED,
that  the  expiration   date  of  any  Incentive   Stock  Option  granted  to  a
greater-than-ten  percent ( >10%) shareholder of the Company (as determined with
reference to Section  424(d) of the Code) shall not be later than five (5) years
from the Date of Grant.  In the  absence of action to the  contrary  by the Plan
Administrator in connection with the grant of a particular Option, and except in
the case of Incentive  Stock  Options as described  above,  all Options  granted
under this Plan shall expire ten (10) years from the Date of Grant.

                  5.5 VESTING SCHEDULE.  No Option shall be exercisable until it
has vested.  The vesting schedule for each Option shall be specified by the Plan
Administrator at the time of grant of the Option;  provided,  that if no vesting
schedule is specified at the time of grant,  the Option shall vest  according to
the following schedule:

                                                       Percentage of
                     Number of Years                  Total Option to
                  FOLLOWING DATE OF GRANT             BE EXERCISABLE

                            1                               20%
                            2                               40%
                            3                               60%
                            4                               80%
                            5                              100%

                  5.6  ACCELERATION  OF  VESTING.  The  vesting  of one or  more
outstanding  Options may be accelerated by the Plan  Administrator at such times
and in such amounts as it shall determine in its sole discretion. If an Employee
Optionee's employment terminates by reason of death or Disability (as defined in
Section  5.7  below),  any Option held by such  Employee  Optionee  who has been
Continuously Employed by the Company or Related Corporation for a minimum of two
(2) years shall  become  fully  vested and  exercisable  and may  thereafter  be
exercised  during  the term of the  Option  set  forth  in  Section  5.7  below.
"Continuously   Employed"  shall  mean  the  absence  of  any   interruption  or
termination  of  service.  Continuous  Employment  with the  Company  or Related
Corporation  shall  not be  considered  interrupted  in the case of sick  leave,
military leave or any other leave of absence  approved by the Company or Related
Corporation  or in the case of  transfers  between  locations  of the Company or
between the Company, Related Corporations or their successors, provided that the
Optionee continues to be an employee of the Company or any Related  Corporation.
The  vesting  of  Options  also  shall be  accelerated  under the  circumstances
described in Sections 5.13 and 5.14 below.

                  5.7 TERM OF OPTION.  Vested  Options shall  terminate,  to the
extent  not  previously  exercised,  upon  the  occurrence  of the  first of the
following  events:  (i) the expiration of the Option,  as designated by the Plan
Administrator  in  accordance  with Section 5.4 above;  (ii) the  expiration  of
ninety (90) days from the date of an  Optionee's  termination  of  employment or
contractual  relationship  with the Company or any Related  Corporation  for any
reason  whatsoever other than death or Disability (as defined below) unless,  in
the case of a Non-Qualified Stock Option, the exercise period is extended by the
Plan  Administrator  until a date  not  later  than the  expiration  date of the
Option;  or (iii) the  expiration  of one (1) year from (A) the date of death of
the  Optionee  or (B)  cessation  of an  Optionee's  employment  or  contractual
relationship by reason of Disability (as defined below) unless, in the case of a
Non-Qualified  Stock  Option,  the  exercise  period  is  extended  by the  Plan
Administrator  until a date not later than the expiration date of the Option. If
an Optionee's employment or contractual relationship is terminated by death, any
Option held by the Optionee shall be  exercisable  only by the person or persons
to whom such  Optionee's  rights under such Option shall pass by the  Optionee's
will or by the laws of descent  and  distribution  of the state or county of the
Optionee's domicile at the time of death.  "Disability" shall mean that a person
is  unable  to  engage  in any  substantial  gainful  activity  by reason of any
medically  determinable  physical or mental  impairment  that can be expected to
result in death or that has lasted or can be expected  to last for a  continuous
period  of not less  than  twelve  (12)  months.  The Plan  Administrator  shall
determine  whether an Optionee has incurred a Disability on the basis of medical
evidence  acceptable to the Plan  Administrator.  Upon making a determination of
Disability, the Committee shall, for purposes of the Plan, determine the date of
an Optionee's termination of employment or contractual relationship.

                  Unless  accelerated  in  accordance  with  Section  5.6 above,
unvested  Options shall terminate  immediately upon termination of employment of
the  Optionee  by the  Company  for any reason  whatsoever,  including  death or
Disability.

                  If, in the case of an Incentive  Stock  Option,  an Optionee's
relationship with the Company changes (e.g., from an Employee to a non-Employee,
such as a  consultant),  such change shall not  constitute a  termination  of an
Optionee's employment with the Company but rather the Optionee's Incentive Stock
Option.  For  purposes of this Section 5.7,  transfer of  employment  between or
among  the  Company  and/or  any  Related  Corporation  shall  not be  deemed to
constitute  a  termination  of  employment  with  the  Company  or  any  Related
Corporation.  For purposes of this Section  5.7,  employment  shall be deemed to
continue while the Optionee is on military leave,  sick leave or other bona fide
leave of  absence  (as  determined  by the Plan  Administrator).  The  foregoing
notwithstanding,  with respect to Incentive Stock Options,  employment shall not
be deemed to continue  beyond the first  ninety (90) days of such leave,  unless
the Optionee's re-employment rights are guaranteed by statute or by contract.

                  5.8 EXERCISE OF OPTIONS. Options shall be exercisable,  either
all or in part, at any time after vesting,  until  termination;  PROVIDED,  that
after  registration of any of the Company's  securities  under Section 12 of the
Exchange  Act,  Optionee  must  comply  with the six (6)  month  holding  period
requirements of Section 16(b) of the Exchange Act and Rule 16b-3 thereunder.  If
less than all of the shares  included  in the  vested  portion of any Option are
purchased,  the remainder may be purchased at any  subsequent  time prior to the
expiration of the Option term. No portion of any Option for less than fifty (50)
shares (as adjusted pursuant to Section 5.13 below) may be exercised;  PROVIDED,
that if the vested portion of any Option is less than fifty (50) shares,  it may
be  exercised  with  respect to all  shares  for which it is vested.  Only whole
shares may be issued  pursuant  to an Option,  and to the extent  that an Option
covers less than one (1) share, it is unexercisable. Options or portions thereof
may be  exercised  by giving to the  Company an  executed  notice of election to
exercise,  which notice shall specify the number of shares to be purchased,  and
be accompanied by payment in the amount of the aggregate  exercise price for the
Common  Stock so  purchased,  which  payment  shall be in the form  specified in
Section 5.9 below.  The Company  shall not be  obligated  to issue,  transfer or
deliver  a  certificate  of Common  Stock to any  Optionee,  or to his  personal
representative,  until the aggregate exercise price has been paid for all shares
for which the Option shall have been  exercised and adequate  provision has been
made  by the  Optionee  for  satisfaction  of any  tax  withholding  obligations
associated with such exercise.  During the lifetime of an Optionee,  Options are
exercisable only by the Optionee.

                  5.9 PAYMENT UPON EXERCISE OF OPTION.  Upon the exercise of any
Option,  the aggregate exercise price shall be paid to the Company in cash or by
certified  or  cashier's   check.  In  addition,   upon  approval  of  the  Plan
Administrator,  an  Optionee  may pay for all or any  portion  of the  aggregate
exercise  price  by (i)  delivering  to  the  Company  shares  of  Common  Stock
previously held by such Optionee, (ii) having shares withheld from the amount of
shares of Common  Stock to be  received by the  Optionee,  (iii)  delivering  an
irrevocable  subscription  agreement obligating the Optionee to take and pay for
the shares of Common  Stock to be  purchased  within one (1) year of the date of
such exercise or (iv)  complying  with any other payment  mechanisms as the Plan
Administrator may approve from time to time. The shares of Common Stock received
or withheld by the Company as payment for shares of Common Stock  purchased upon
the  exercise of Options  shall have a fair market value at the date of exercise
(as determined by the Plan Administrator)  equal to the aggregate exercise price
(or portion thereof) to be paid by the Optionee upon such exercise.

                  5.10 RIGHTS AS A SHAREHOLDER. An Optionee shall have no rights
as a  shareholder  with  respect to any shares  covered by an Option  until such
Optionee  becomes a record holder of such shares,  irrespective  of whether such
Optionee  has given notice of exercise.  Subject to the  provisions  of Sections
5.13 and 5.14 below,  no rights shall  accrue to an Optionee and no  adjustments
shall be made on account of  dividends  (ordinary or  extraordinary,  whether in
cash,  securities or other property) or  distributions  or other rights declared
on, or created  in, the Common  Stock for which the record  date is prior to the
date the Optionee  becomes a record holder of the shares of Common Stock covered
by the  Option,  irrespective  of  whether  such  Optionee  has given  notice of
exercise.

                  5.11 TRANSFER OF OPTION.  Options  granted under this Plan and
the  rights  and  privileges  conferred  by this  Plan  may not be  transferred,
assigned,  pledged or hypothecated in any manner (whether by operation of law or
otherwise) other than by will or by applicable laws of descent and distribution,
as defined by the Code, or the Employee  Retirement  Income Security Act, or the
rules  and  regulations  thereunder,  and  shall not be  subject  to  execution,
attachment or similar  process.  Upon any attempt to transfer,  assign,  pledge,
hypothecate  or  otherwise  dispose of any  Option or of any right or  privilege
conferred by this Plan contrary to the provisions hereof, or upon the sale, levy
or any attachment or similar process upon the rights and privileges conferred by
this Plan, such Option shall thereupon terminate and become null and void.

                  5.12     SECURITIES REGULATION AND TAX WITHHOLDING.

                           5.12.1   Shares shall not be issued with respect to 
an Option  unless the exercise of such Option and the issuance and delivery
of such shares  shall  comply with all relevant  provisions  of law,  including,
without limitation,  any applicable state securities laws, the Securities Act of
1933,  as amended,  the  Exchange  Act, as  amended,  the rules and  regulations
thereunder and the requirements of any stock exchange upon which such shares may
then be listed,  and such issuance  shall be further  subject to the approval of
counsel  for  the  Company  with  respect  to  such  compliance,  including  the
availability of an exemption from registration for the issuance and sale of such
shares.  The  inability  of the Company to obtain from any  regulatory  body the
authority deemed by the Company to be necessary for the lawful issuance and sale
of any shares  under this  Plan,  or the  unavailability  of an  exemption  from
registration  for the  issuance  and sale of any shares  under this Plan,  shall
relieve the Company of any liability with respect to the non-issuance or sale of
such shares.

         As a condition to the exercise of an Option, the Plan Administrator may
require  the  Optionee to  represent  and warrant in writing at the time of such
exercise that the shares are being purchased only for investment and without any
then-present  intention to sell or distribute such shares.  At the option of the
Plan  Administrator,  a stop-transfer order against such shares may be placed on
the stock books and records of the  Company,  and a legend  indicating  that the
stock may not be pledged,  sold or  otherwise  transferred  unless an opinion of
counsel is  provided  stating  that such  transfer  is not in  violation  of any
applicable law or regulation,  may be stamped on the  certificates  representing
such  shares  in  order to  assure  an  exemption  from  registration.  The Plan
Administrator also may require such other documentation as may from time to time
be necessary to comply with federal and state  securities  laws. THE COMPANY HAS
NO  OBLIGATION  TO  UNDERTAKE  REGISTRATION  OF  OPTIONS  OR THE SHARES OF STOCK
ISSUABLE UPON THE EXERCISE OF OPTIONS.

                           5.12.2   As a condition to the exercise of any 
Option granted under this Plan,  the Optionee shall make such  arrangements
as the Plan Administrator may require for the satisfaction of any federal, state
or local  withholding  tax  obligations  that may arise in connection  with such
exercise.

                           5.12.3   The issuance, transfer or delivery of 
certificates  of Common  Stock  pursuant to the  exercise of Options may be
delayed,  at  the  discretion  of  the  Plan   Administrator,   until  the  Plan
Administrator  is satisfied that the applicable  requirements of the federal and
state securities laws and the withholding provisions of the Code have been met.

                  5.13     STOCK DIVIDEND, REORGANIZATION OR LIQUIDATION.

                           5.13.1   If (i) the Company shall at any time be 
involved in a transaction  described in Section  424(a) of the Code (or any
successor provision) or any "corporate transaction" described in the regulations
thereunder,  (ii) the  Company  shall  declare a dividend  payable  in, or shall
subdivide  or  combine,   its  Common  Stock  or  (iii)  any  other  event  with
substantially  the same effect shall occur,  then the Plan  Administrator  shall
proportionately  adjust  the  number of shares of Common  Stock  authorized  for
issuance  under  this  Plan  pursuant  to  Section 4 above,  and  shall  further
proportionately  adjust the number of shares of Common Stock and/or the exercise
price per share with respect to each Option then  outstanding  so as to preserve
the  rights of the  Optionee  substantially  proportionate  to the rights of the
Optionee prior to such event, all without further action on the part of the Plan
Administrator, the Company or the Company's shareholders.

                           5.13.2   If the Company is liquidated or dissolved, 
the Plan Administrator  shall allow the holders of any outstanding  Options
to exercise all or any part of the unvested portion of the Options held by them;
PROVIDED,  that such Options must be exercised  prior to the  effective  date of
such  liquidation  or  dissolution.  If the Option holders do not exercise their
Options prior to such effective date, each outstanding Option shall terminate as
of the effective date of the liquidation or dissolution.

                           5.13.3   The foregoing adjustments in the shares 
subject  to  Options  shall  be made by the Plan  Administrator,  or by any
successor  administrator  of  this  Plan,  or by  the  applicable  terms  of any
assumption or substitution document.

                           5.13.4   The grant of an Option shall not affect in 
any  way  the  right  or  power  of  the   Company  to  make   adjustments,
reclassifications,  reorganizations  or  changes  of  its  capital  or  business
structure,  to  merge,  consolidate  or  dissolve,  to  liquidate  or to sell or
transfer all or any part of its business or assets.

            5.14     CHANGE IN CONTROL; DECLARATION OF EXTRAORDINARY DIVIDEND.

                           5.14.1   CHANGE IN CONTROL.  If at any time there is
a Change in Control (as defined  below) of the Company,  all Options  shall
accelerate and become fully vested and immediately  exercisable for the duration
of the Option term. For purposes of this Subsection 5.14.1,  "Change in Control"
shall mean either one of the  following:  (i) When any "person," as such term is
used in sections  13(d) and 14(d) of the Exchange Act (other than a  shareholder
of the  Company  on the date of this  Plan,  the  Company,  a  Subsidiary  or an
employee benefit plan of the Company,  including any trustee of such plan acting
as trustee)  becomes,  after the date of this Plan, the  "beneficial  owner" (as
defined in Rule 13d-3  under the  Exchange  Act),  directly  or  indirectly,  of
securities  of the  Company  representing  fifty  percent  (50%)  or more of the
combined voting power of the Company's then outstanding securities;  or (ii) the
occurrence of a transaction requiring  shareholder  approval,  and involving the
sale of all or  substantially  all of the assets of the Company or the merger of
the Company with or into another corporation.

                           5.14.2   DECLARATION OF EXTRAORDINARY DIVIDEND.  If 
at any time the Company  declares  an  Extraordinary  Dividend  (as defined
below),  all Options  shall  accelerate  and  thereupon  become fully vested and
immediately  exercisable  for the duration of the Option  term.  For purposes of
this  Subsection  5.14.2,  "Extraordinary  Dividend"  shall mean a cash dividend
payable to  holders of record of the Common  Stock in an amount in excess of ten
percent (10%) of the then fair market value of the Company's  Common Stock.  The
fair market  value of the  Company's  Common Stock shall be  determined  in good
faith by the Board.

         6. EFFECTIVE DATE; TERM. This Plan shall be effective as of the closing
of the initial public offering of securities of the Company under the Securities
Act of 1933.  Incentive  Stock Options may be granted by the Plan  Administrator
from  time  to time  thereafter  until  ten  (10)  years  after  such  approval.
Non-Qualified  Stock Options may be granted until this Plan is terminated by the
Board in its sole  discretion.  Termination of this Plan shall not terminate any
Option granted prior to such termination.

         7.       NO OBLIGATIONS TO EXERCISE OPTION.  The grant of an Option 
shall impose no obligation upon the Optionee to exercise such Option.

         8. NO RIGHT TO OPTIONS OR TO EMPLOYMENT. The grant of any Options under
this Plan shall be exclusively within the discretion of the Plan  Administrator,
and nothing  contained  in this Plan shall be construed as giving any person any
right to participate  under this Plan. The Plan shall not confer on any Optionee
any  right  with  respect  to  continuation  of any  employment  or  contractual
relationship with the Company or any Related Corporation, nor shall it interfere
in any way with the  Company's  or, where  applicable,  a Related  Corporation's
right to terminate any Optionee's employment or contractual  relationship at any
time, which right is hereby reserved.

         9.       APPLICATION OF FUNDS.  The proceeds received by the Company 
from the sale of Common Stock issued upon the exercise of Options  shall be
used for general corporate purposes, unless otherwise directed by the Board.

         10.  INDEMNIFICATION  OF PLAN  ADMINISTRATOR.  In addition to all other
rights of indemnification  they may have as members of the Board, members of the
Plan  Administrator  shall be  indemnified  by the  Company  for all  reasonable
expenses and liabilities of any type or nature,  including reasonable attorneys'
fees,  incurred in connection with any action,  suit or proceeding to which they
or any of them are a party by reason of, or in connection with, this Plan or any
Option  granted  under  this  Plan,  and  against  all  amounts  paid by them in
settlement  thereof  (provided  that such  settlement is approved by independent
legal counsel selected by the Company),  except to the extent that such expenses
relate to matters for which it is adjudged that such Plan  Administrator  member
is liable for willful misconduct;  PROVIDED, that within fifteen (15) days after
the institution of any such action,  suit or proceeding,  the Plan Administrator
member involved  therein shall,  in writing,  notify the Company of such action,
suit or  proceeding,  so that  the  Company  may have  the  opportunity  to make
appropriate arrangements to prosecute or defend the same.

         11. AMENDMENT OF PLAN. The Plan Administrator may, at any time, modify,
amend or terminate  this Plan and Options  granted  under this Plan,  including,
without  limitation,  such  modifications  or  amendments  as are  necessary  to
maintain compliance with applicable  statutes,  rules or regulations;  PROVIDED,
that no amendment with respect to an  outstanding  Option shall be made over the
objection  of the  Optionee  thereof;  and  PROVIDED  FURTHER,  that,  following
registration of any of the Company's securities under Section 12 of the Exchange
Act,  the  approval of the holders of a majority  of the  Company's  outstanding
shares of voting  capital  stock  represented  at a meeting at which a quorum is
present is required  within  twelve (12) months  before or after the adoption by
the Plan Administrator of any amendment that will permit the granting of Options
to a class of persons  other than those  currently  eligible to receive  Options
under  this  Plan  or that  would  cause  this  Plan to no  longer  comply  with
Securities and Exchange Commission Rule 16b-3, as amended, or any successor rule
or  other  regulatory  requirements.  Without  limiting  the  generality  of the
foregoing,  the Plan Administrator may modify grants to persons who are eligible
to receive Options under this Plan who are foreign nationals or employed outside
the United States to recognize differences in local law, tax policy or custom.






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