OSTEX INTERNATIONAL INC /WA/
10-Q, 1998-05-15
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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<PAGE>


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 10-Q



- ------  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES
  X                           EXCHANGE ACT OF 1934
- ------
                  FOR THE QUARTERLY PERIOD ENDED MARCH 31, 1998

                                    -- or --
      
- ------ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES
  X                           EXCHANGE ACT OF 1934
- ------
      
                        FOR THE TRANSITION PERIOD FROM       TO     
                                                       -----    -----

                              --------------------
                                     0-25250
                             COMMISSION FILE NUMBER

                            OSTEX INTERNATIONAL, INC.
                 NAME OF REGISTRANT AS SPECIFIED IN ITS CHARTER


                               STATE OF WASHINGTON
          STATE OR OTHER JURISDICTION OF INCORPORATION OR ORGANIZATION

                                   91-1450247
                      I.R.S. EMPLOYER IDENTIFICATION NUMBER

          2203 AIRPORT WAY SOUTH, SUITE 400, SEATTLE, WASHINGTON 98134
                                  206-292-8082
           ADDRESS AND TELEPHONE NUMBER OF PRINCIPAL EXECUTIVE OFFICES


                                      [N/A]
       FORMER NAME, ADDRESS AND FISCAL YEAR, IF CHANGED SINCE LAST REPORT

                              --------------------

    Indicate  by  checkmark  whether  the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange
Act of 1934 during the preceding 12 months (or for such shorter  period that the
registrant  was required to file such  reports) and (2) has been subject to such
filing requirements for the past 90 days.

Yes   X     No  
    -----     -----

    THE NUMBER OF SHARES OF THE REGISTRANT'S  COMMON STOCK OUTSTANDING AS OF MAY
7, 1998 WAS 12,696,250.

                              --------------------


<PAGE>


                            OSTEX INTERNATIONAL, INC.

                               INDEX TO FORM 10-Q

                         PART I - FINANCIAL INFORMATION

                                                                 PAGE
                                                                 ----
ITEM 1 - FINANCIAL STATEMENTS                                     2

       Condensed Balance Sheets                                   F-1

       Condensed Statements of Operations                         F-2

       Condensed Statements of Cash Flow                          F-3

       Notes to Condensed Financial Statements                    F-4

ITEM 2 - MANAGEMENT'S DISCUSSION AND ANALYSIS OF
         FINANCIAL CONDITION AND RESULTS OF OPERATIONS            2

ITEM 3 - QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT
         MARKET RISK                                              5

                          PART II -- OTHER INFORMATION

ITEM 1 - LEGAL PROCEEDINGS                                        5

ITEM 6 - EXHIBITS AND REPORTS ON FORM 8-K                         6



<PAGE>


                         PART I -- FINANCIAL INFORMATION


ITEM 1.    FINANCIAL STATEMENTS

       Attached hereto are Ostex International, Inc.'s (the "Company's or Ostex'
") unaudited condensed balance sheet as of March 31, 1998, and audited condensed
balance  sheet as of December 31, 1997,  the unaudited  condensed  statements of
operations for the three months ended March 31, 1998 and 1997, and the unaudited
condensed  statements of cash flow for the three months ended March 31, 1998 and
1997. Notes follow the unaudited  financial  statements and are an integral part
thereof.


ITEM 2.    MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION 
           AND RESULTS OF OPERATIONS

         This Quarterly Report on Form 10-Q contains forward-looking  statements
which  reflect the  Company's  current  views with respect to future  events and
financial performance.  These forward-looking  statements are subject to certain
risks and  uncertainties,  including  those  discussed  below,  that could cause
actual  results  or the  timing of  certain  events to  differ  materially  from
historical results or those  anticipated.  Words used herein such as "believes,"
"anticipates,"  "expects,"  "intends," and similar  expressions  are intended to
identify  forward-looking   statements  but  are  not  the  exclusive  means  of
identifying such statements.  In addition,  the disclosures in this Item 2 under
the  caption  "Other  Factors  that  May  Affect  Operating  Results",   consist
principally  of a brief  discussion of risks which may affect future results and
are thus, in their  entirety,  forward-looking  in nature.  Readers are urged to
carefully  review and  consider the various  disclosures  made by the Company in
this  report  and in the  Company's  other  reports  previously  filed  with the
Securities and Exchange Commission (the  "Commission"),  including the Company's
Annual  Report on Form 10-K for the fiscal year ended  December 31,  1997,  that
attempt to advise  interested  parties of the risks and factors  that may affect
the Company's business.

OVERVIEW

       Ostex was incorporated in the State of Washington in 1989. The Company is
engaged in the  discovery  and  commercialization  of products  associated  with
osteoporosis and other collagen-related  diseases. The Company believes that its
lead product, the OSTEOMARK-registered trademark- test, incorporates 
breakthrough technology in the area of bone resorption measurement.

       Osteoporosis is a significant  health problem.  According to the National
Osteoporosis  Foundation (the "NOF"),  osteoporosis  afflicts  approximately  28
million people in the U.S. alone. Additionally millions of people are at risk of
skeletal  degradation  associated  with  Paget's  disease of bone,  cancer  that
metastasizes  to  bone,  hyperparathyroidism  (overactivity  of the  parathyroid
gland,  characterized by a reduction of bone mass) and renal osteodystrophy.  In
spite  of  the  serious  human  and  economic  consequences  of  these  diseases
(according  to the NOF, the direct  healthcare  and indirect  lost  productivity
costs of osteoporosis  exceed $10 billion annually in the U.S.  alone),  medical
intervention usually commences only after pain, immobility,  fractures, or other
symptoms have appeared. The Company expects the osteoporosis  therapeutic market
will increase significantly.  The Company also believes new therapeutic products
are under development for osteoporosis, some of which are in late-stage clinical
trials,  and  that  the  Osteomark  test can be used to  effectively  predict  a
patient's  response to osteoporosis  therapy and monitor existing  therapies and
other therapies which may be developed.

       The Company is the exclusive licensee of the Osteomark technology,  known
clinically  as the NTx assay,  which is a urine test that can aid in  healthcare
decision-making  at  early  menopause  and  beyond.  The  Osteomark  assay  is a
non-invasive  diagnostic test which  quantitatively  indicates the level of bone
resorption.  Individuals  who are losing bone collagen at accelerated  rates may
progress to low bone mass, a major cause of  osteoporosis.  The Company believes
that  early  identification  of high  levels  of bone  resorption  provides  the
opportunity  to predict  skeletal  response  (bone mineral  density) to hormonal
antiresorptive therapy in postmenopausal women which are intended to prevent the
onset of  osteoporosis.  The Company also believes that the Osteomark assay aids
clinicians   in   monitoring   the  effects  of   antiresorptive   therapies  in
postmenopausal  women,  as well as in  older  patients  who  have  already  lost
significant bone mass.

<PAGE>

       On May  8,  1995,  the  Company's  Osteomark  assay  became  commercially
available in the United States as a urinary  assay that provides a  quantitative
measure of the excretion of cross-linked N-telopeptides of Type I collagen (NTx)
as an indicator of human bone resorption,  and in July 1996 the Company received
expanded claims from the Food and Drug Administration (the "FDA") for the assay.
The 1996 claims allow that an Osteomark test measurement,  if taken prior to the
initiation  of  hormonal  antiresorptive  therapy,  can be utilized to predict a
patient's  response  to that  therapy,  in terms of its  effect on bone  mineral
density.  Additionally,  the  claims  allow  that  the  test  can  be  used  for
therapeutic  monitoring of antiresorptive  therapies in postmenopausal women, as
well as individuals  diagnosed with  osteoporosis and Paget's  disease,  and for
therapeutic  monitoring  of  estrogen-suppressing  therapies.  In March 1998 the
claims were further  expanded by allowing  that, in addition to the 1996 claims,
an Osteomark test measurement can identify the probability of a decrease in bone
mineral density in postmenopausal  women taking calcium supplements  relative to
those treated with hormonal antiresorptive therapy.

       The Company is manufacturing  and marketing the Osteomark assay initially
in an Enzyme-linked  Immunosorbent  Assay ("ELISA")  microtiter plate format for
testing  urine  samples and is in the latter  stages of adapting  the  Osteomark
assay to a serum format.  The Company  believes that the use of a serum NTx test
provides  a  number  of  advantages  to  testing  laboratories,   including  the
elimination   of  the   requirement   to  normalize  NTx  values  to  creatinine
concentration and to ultimately perform NTx testing on random access,  automated
analyzers.  The Company plans to initiate clinical studies of its serum NTx test
in an ELISA format during the second quarter of 1998.

       Worldwide  promotion of the Osteomark test kits is supported by Johnson &
Johnson Clinical  Diagnostics,  Inc. ("Johnson & Johnson").  In 1995 the Company
entered into research, development, license and supply agreements with Johnson &
Johnson. These agreements grant Johnson & Johnson a license to manufacture, sell
and  distribute  certain  products  using  Ostex's bone  resorption  technology.
Currently,  Ostex sells  Johnson & Johnson the  Osteomark  assay in the existing
microtiter  plate  format  for  distribution  in the United  States and  certain
foreign countries and Johnson & Johnson is adapting the urine assay for use with
its  automated  analyzer.  Ostex will  receive  royalties on Johnson & Johnson's
automated analyzer sales of products incorporating licensed Ostex technology.

       Ostex has also entered into a research and  development  agreement  and a
license agreement with Mochida Pharmaceutical Co., Ltd. ("Mochida"),  a Japanese
pharmaceutical  company,  for the  commercialization  of the Osteomark  assay in
Japan.  Under the research and development  agreement,  Mochida has an option to
license the NTx serum assay upon  completion  of certain  milestones.  Under the
license  agreement,  Ostex granted Mochida exclusive  marketing and distribution
rights to certain  Ostex  products  in Japan,  and Ostex  sells to  Mochida  the
critical reagents  necessary for Mochida to assemble  Osteomark kits. In January
1998  Mochida  launched  the  Osteomark  assay in Japan  for the  management  of
patients with hyperparathyroidism and for patients with metastatic bone tumors.

       The Company also plans to develop the Osteomark  assay in other  formats,
including  formats suitable for use in the physician's  office.  The Company has
entered into agreements with Hologic,  Inc.  ("Hologic"),  a worldwide leader in
X-ray and  ultrasound  bone  sonometers  used to measure  and/or  estimate  bone
density to assist in the diagnosis and monitoring of osteoporosis and other bone
diseases, and Metrika, Inc. ("Metrika"), a diagnostic device company, to develop
physician office "point-of-care" Osteomark assay devices.

<PAGE>

RESULTS OF OPERATIONS FOR THE THREE MONTHS ENDED MARCH 31, 1998 
AND MARCH 31, 1997

       Total  revenues  were  $581,000  for the quarter  ended  March 31,  1998,
compared to $654,000 for the quarter  ended March 31, 1997.  Product  sales were
$556,000  and research  testing  services  were  $25,000  during the three month
period ended March 31, 1998,  compared to product sales of $654,000 for the same
period in 1997.  The  decrease  in  product  sales was due to lower  orders  for
Osteomark kits from domestic reference laboratories.

       The  Company's  gross margin  decreased to 67% in the quarter ended March
31, 1998,  compared to a gross margin of 77% in the first quarter of 1997. While
overall  pricing  levels have  increased  slightly in the first  quarter of 1998
compared to the 1997 quarter,  lower production volume  negatively  impacted the
1998 quarter.  Cost of products sold  primarily  include labor costs,  materials
management,  equipment and facility costs. The increase of cost of products sold
in the first  quarter of 1998 compared to the same quarter in 1997 resulted from
a slight  increase in labor costs and royalty  payments on product sales,  and a
lower production volume compared to the 1997 first quarter. The lower production
volume adversely  impacted gross margin as unabsorbed  overhead was allocated to
cost of products sold in the quarter  ended March 31, 1998.  The gross margin is
expected to continue to fluctuate depending on the volume and timing of customer
orders and the production levels needed to fill customer demand.

       The Company's research and development  expenditures totaled $835,000 for
the quarter ended March 31, 1998,  compared to $1,078,000  for the quarter ended
March 31, 1997.  The $243,000  decrease was primarily  attributable  to a higher
level of clinical trial activity in the 1997 quarter.  Included in the Company's
clinical  studies  in the 1997  quarter  was a study for  variability  of NTx in
postmenopausal  women, a study for the  determination of variability and the NTx
reference  range in  males,  and a study  for the use of the  Osteomark  test in
helping to identify  bone  metastases.  The  Company  anticipates  research  and
development  expenses to increase in future  quarters with the  commencement  of
further clinical trials.  The decrease in research and development  expenses was
also  attributable to a restructuring of the University of Washington (the "UW")
research agreements during 1997. The restructuring  reduced the expenses paid to
the UW for research  during the quarter  ended March 31,  1998,  compared to the
same quarter 1997.

       Selling,  general and administrative  expenses totaled $2,251,000 for the
quarter ended March 31, 1998, compared to $1,923,000 for the quarter ended March
31, 1997. The $328,000  increase in the 1998 quarter was primarily due to higher
costs  associated with patent  prosecution,  litigation costs in connection with
the Company's legal action against  Osteometer Biotech A/S  ("Osteometer"),  and
defense costs  associated with  litigation  initiated by C.R. Bard ("Bard") (see
"Legal  Proceedings"  in Part II,  Item 1 of this  10-Q).  Selling,  general and
administrative  expenses  in the first  quarter  of 1998 also  increased  due to
promotion and advertising of the Osteomark test.

       Interest  income  totaled  $218,000 for the quarter ended March 31, 1998,
compared to $249,000 for the quarter  ended March 31, 1997.  The decrease is due
to lower  invested  balances  resulting  from using  cash to fund the  Company's
operating losses.


LIQUIDITY AND CAPITAL RESOURCES

       As of March  31,  1998,  the  Company  had  $16,404,000  in cash and cash
equivalents and short-term investments, working capital of $15,947,000 and total
shareholders'  equity of $19,123,000.  As a result of funding  operating  losses
during the three  months  ended  March 31,  1998,  cash,  cash  equivalents  and
short-term  investments  decreased by $2,561,000,  working capital  decreased by
$2,421,000 and  shareholders  equity  decreased by $2,521,000.  During the three
month period ended March 31, 1998 the Company  purchased $17,000 in property and
equipment and reduced notes payable by $44,000.

         The Company's  future  capital  requirements  depend upon many factors,
including  the timing and  effectiveness  of  commercialization  activities  and
collaborative  arrangements;  continued  scientific progress in its research and
development  programs;  the costs involved in filing,  prosecuting and enforcing
patent claims; the costs involved in legal efforts to enforce patent rights; and
the time and costs involved in obtaining  regulatory  approvals.  The Company is
likely to require  additional  funds from equity or debt financing and there can
be no assurance that such additional funds will be available on favorable terms,
if at all. Due to the Company's significant long-term cash requirements,  it may

<PAGE>

seek to raise additional  capital if conditions in the public equity markets are
favorable,  even if the Company does not have an immediate  need for  additional
cash at that  time.  If  additional  financing  is not  available,  the  Company
anticipates  that its existing  available  cash, its future license and research
revenues  from  existing  collaboration  agreements,  product sales and interest
income  from  short-term  investments  will be  adequate  to satisfy its capital
requirements  and to fund  operations  through  1999. No assurance can be given,
however,  that such funds will in fact be  adequate  until that time,  since the
Company's  prediction  is  subject  to a  number  of  risks  and  uncertainties,
including those discussed in the following paragraph.

OTHER FACTORS THAT MAY AFFECT OPERATING RESULTS

         The  Company's  operating  results  may  fluctuate  due to a number  of
factors  including,  but not  limited  to,  volume and timing of product  sales,
product pricing, market acceptance of the Company's products,  changing economic
conditions in the healthcare industry, delays and increased costs of product and
technology   development,   the  Company's   ability  to  develop  and  maintain
collaborative arrangements, the timing of payments under those arrangements, the
outcome of litigation,  and the effect of the Company's accounting policies,  as
well as other risk factors  detailed in the  Company's  1997 Form 10-K and other
Commission  filings.  All of the foregoing factors are difficult for the Company
to predict  and can  materially  adversely  affect the  Company's  business  and
operating results.


ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

       Not Applicable


                          PART II -- OTHER INFORMATION


ITEM 1.    LEGAL PROCEEDINGS

       In June 1996,  the Company filed an action in the United States  District
Court for the Western  District of  Washington  against  Osteometer  Biotech A/S
("Osteometer"),  a medical technology  company based in Denmark,  and Diagnostic
Systems  Laboratories  Inc. for patent  infringement of United States Patent No.
5,455,179.   The  Company  believes  Osteometer's  bone  resorption  immunoassay
incorporates technology which infringes patented Ostex technology.  In September
1996, the defendants  filed a response denying  infringement and  counterclaimed
that Ostex'  patent is invalid and  unenforceable.  By order dated July 7, 1997,
the Court granted  Ostex's  motion to file a  supplemental  complaint,  to add a
second  cause of action based upon United  States  Patent No.  5,641,837,  which
issued on June 24, 1997. On October 24, 1997, Ostex filed a second  supplemental
complaint to add third and fourth  causes of action  based upon U.S.  Patent No.
5,652,112,  which issued on July 29, 1997, and U.S. Patent No. 5,656,439,  which
issued  on August  12,  1997.  The  lawsuit  is  currently  scheduled  for trial
commencing  February  23,  1999.  Management  intends to continue to  vigorously
assert its position in the lawsuit.

       On April 9, 1997,  the  Company  was served  with a lawsuit  filed in the
United  States  District  Court,  Central  District of  California  by C.R. Bard
("Bard").  The complaint  alleged that Ostex' Osteomark  product  infringes U.S.
Patent No.  4,628,027  assigned to Bard in 1993.  On April 22,  1998,  the Court
issued an order granting Ostex' motion for summary judgment and dismissed Bard's
lawsuit with prejudice.

<PAGE>

ITEM 6.    EXHIBITS AND REPORTS ON FORM 8-K

       (A) EXHIBITS

       The following exhibits are filed herewith:

       10.2A        Amendment to the Amended and Restated
                    Directors' Nonqualified Stock Option Plan
       27.1         Financial Data Schedule


       (B) REPORTS ON FORM 8-K

       None





                                   SIGNATURES


       Pursuant to the requirements of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned, thereunto duly authorized.


                                          OSTEX INTERNATIONAL, INC.



       DATED:  May 14, 1998               By    /S/ ROBERT M. LITTAUER
                                            --------------------------------
                                                 Robert M. Littauer
                                               Senior Vice President,
                                             Finance and Administration
                                         (principal financial and principal 
                                                 accounting officer)

<PAGE>

<TABLE>
<CAPTION>

                            OSTEX INTERNATIONAL, INC.

                            CONDENSED BALANCE SHEETS
                      (IN THOUSANDS, EXCEPT SHARE AMOUNTS)


                                                         March 31,           December 31,
                                                           1998                 1997
                                                      -----------------   ------------------
                                                         (unaudited)
<S>                                                   <C>                 <C> 
CURRENT ASSETS:
     Cash and cash equivalents                        $          267      $        2,201
     Short-term investments                                   16,137              16,764
     Trade receivables and other current assets, net           1,087               1,344
     Inventory, at cost                                          246                 201
                                                      -----------------   ------------------
        Total current assets                                  17,737              20,510

PROPERTY, PLANT AND EQUIPMENT, net of accumulated
     depreciation                                              2,813               2,965

OTHER ASSETS                                                     637                 637

                                                      =================   ==================
        Total assets                                  $       21,187      $       24,112
                                                      =================   ==================


CURRENT LIABILITIES:
     Accounts payable and accrued expenses            $        1,790      $        2,142

NONCURRENT LIABILITIES:
     Note payable, net of current portion                        274                 326
                                                      -----------------   ------------------

        Total liabilities                                      2,064               2,468
                                                      -----------------   ------------------

SHAREHOLDERS' EQUITY:
     Common Stock, $.01 par value, 50,000,000
        authorized; 12,696,250 issued
        and outstanding                                          127                 127
     Additional paid-in capital                               45,642              45,642
     Accumulated other comprehensive 
        income - unrealized gain/(loss) on  
        short-term investments                                   (27)                  3
     Accumulated deficit                                     (26,619)            (24,128)
                                                      -----------------   ------------------
        Total shareholders' equity                            19,123              21,644
                                                      -----------------   ------------------

        Total liabilities and shareholders' equity    $       21,187       $      24,112
                                                      =================   ==================

</TABLE>

     The  accompanying  notes  are an  integral  part  of  these condensed 
balance sheets.


<PAGE>

<TABLE>
<CAPTION>

                            OSTEX INTERNATIONAL, INC.

                       CONDENSED STATEMENTS OF OPERATIONS
                    (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)
                                   (UNAUDITED)

                                                                 Quarter Ended
                                                     --------------------------------------
                                                         March 31,            March 31,
                                                           1998                 1997
                                                     ------------------   -----------------
<S>                                                  <C>                  <C>
REVENUE:
     Product sales and research testing services     $       581          $       654
                                                     ------------------   -----------------

OPERATING EXPENSES:
     Cost of products sold                                   189                  151
     Research and development                                835                1,078
     Selling, general and administrative                   2,251                1,923
                                                     ------------------   -----------------
          Total operating expenses                         3,275                3,152
                                                     ------------------   -----------------

          Loss from operations                            (2,694)              (2,498)

OTHER INCOME (EXPENSE):
     Interest income                                         218                  249
     Interest expense                                        (15)                 (20)

                                                     ------------------   -----------------
          Net loss                                   $     (2,491)        $    (2,269)
                                                     ------------------   -----------------


Basic and diluted net loss per common and
     common equivalent share                         $      (0.20)        $     (0.18)
                                                     ==================   =================
Shares used in calculation of net loss per share           12,696              12,448
                                                     ==================   =================

</TABLE>
     
     The  accompanying  notes are an integral part of these  condensed
financial statements.


<PAGE>

<TABLE>
<CAPTION>

                            OSTEX INTERNATIONAL, INC.

                        CONDENSED STATEMENTS OF CASH FLOW
                                 (IN THOUSANDS)
                                   (UNAUDITED)

                                                                 Quarter Ended
                                                       --------------------------------------
                                                             March 31,            March 31,
                                                               1998                1997
                                                       ------------------   -----------------
<S>                                                    <C>                  <C>   
CASH FLOWS FROM OPERATING ACTIVITIES                   $       (2,470)      $      (2,632)
                                                       ------------------   -----------------

CASH FLOWS FROM INVESTING ACTIVITIES:
     Purchases of short-term investments                      (18,538)             (3,033)
     Proceeds from sales of short-term investments             19,135               5,276
     Purchase of property, plant and equipment                    (17)               (174)
                                                       ------------------   -----------------
            Net cash provided by investing activities             580               2,069
                                                       ------------------   -----------------

CASH FLOWS FROM FINANCING ACTIVITIES:
     Proceeds from exercise of common stock options                 -                  26
     Payments on note payable                                     (44)                (39)
                                                       ------------------   -----------------
            Net cash used in financing activities                 (44)                (13)
                                                       ------------------   -----------------

NET DECREASE IN CASH AND CASH
     EQUIVALENTS                                               (1,934)               (576)

CASH AND CASH EQUIVALENTS, beginning of period                  2,201               1,289

                                                       ------------------   -----------------
CASH AND CASH EQUIVALENTS, end of period               $          267       $         713
                                                       ==================   =================

</TABLE>

     The  accompanying   notes  are  an  integral  part  of  these condensed 
financial statements.


<PAGE>
                                                       

                            OSTEX INTERNATIONAL, INC.

                     NOTES TO CONDENSED FINANCIAL STATEMENTS


1.  SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

BASIS OF PRESENTATION

The  unaudited  condensed  financial  statements  include the  accounts of Ostex
International,  Inc. (a Washington corporation) (the "Company"). These financial
statements have been prepared in accordance with generally  accepted  accounting
principles  for  interim  financial  reporting  and  pursuant  to the  rules and
regulations of the Securities and Exchange  Commission.  While these  statements
reflect  all  normal  recurring   adjustments  which  are,  in  the  opinion  of
management,  necessary  for fair  presentation  of the  results  of the  interim
periods,  they do not include all of the information  and footnotes  required by
generally accepted accounting principles for complete financial statements.  For
further  information,  refer to the financial  statements and footnotes  thereto
included in the  Company's  Annual  Report filed on Form 10-K for the year ended
December 31, 1997.


NET LOSS PER COMMON AND COMMON EQUIVALENT SHARE

The Company adopted SFAS No. 128,  "Earnings per Share," effective  December 15,
1997.  Basic net loss per share is the net loss divided by the average number of
shares  outstanding during the year. Diluted net loss per share is calculated as
the net loss  divided  by the sum of the  average  number of shares  outstanding
during the year plus the net  additional  shares that would have been issued had
all dilutive options been exercised,  less shares that would be repurchased with
the  proceeds  from such  exercise  (Treasury  Stock  Method).  During all years
presented,   the  effect  of  including  outstanding  options  is  antidilutive,
therefore,  no options are considered in the calculation of diluted net loss per
share. There is no difference between the previously reported net loss per share
and the basic and diluted net loss per share.


2.  CONTINGENCIES

LEGAL PROCEEDINGS

Refer to Part II, Item 1 of this Form 10-Q.


3.  NEW ACCOUNTING PRONOUNCEMENTS

The Company has adopted SFAS No. 130, "Reporting  Comprehensive  Income",  which
establishes  standards for reporting and disclosure of comprehensive income. The
components of comprehensive income for the three months ended March 31, 1998 and
March 31, 1997, are as follows (in thousands) :

                                            March 31,       March 31,
                                              1998            1997
                                            ---------       ---------
         Net loss                           $ (2,491)       $ (2,269)
         Unrealized gain/(loss)
           on short-term investments             (30)           (171)
                                            ---------       ---------
         Total comprehensive loss           $ (2,521)       $ (2,440)
                                            =========       =========




                                  EXHIBIT 10.2A

                            OSTEX INTERNATIONAL, INC.

             AMENDMENT TO DIRECTORS' NONQUALIFIED STOCK OPTION PLAN


         An amendment to the Amended and Restated Directors'  Nonqualified Stock
Option  Plan was made by  inserting  the  following  sentence  after  the  third
sentence of Section 3:

         "In addition, each Director who was in office immediately following the
annual meeting of the Company's  shareholders  on June 2, 1997 and whose initial
grant was for less than a total of 25,000  shares shall be granted,  as of March
4, 1998 (the date of amendment),  an amount of shares,  which when added to such
initial  grant  equals  25,000  shares,  such grant to vest from the date of the
initial grant over the following three years as provided in Section 4.4."



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<ARTICLE> 5
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1998
<PERIOD-END>                               MAR-31-1998
<CASH>                                             267
<SECURITIES>                                    16,137
<RECEIVABLES>                                      576
<ALLOWANCES>                                        25
<INVENTORY>                                        246
<CURRENT-ASSETS>                                17,737
<PP&E>                                           4,695
<DEPRECIATION>                                   1,882
<TOTAL-ASSETS>                                  21,187
<CURRENT-LIABILITIES>                            1,790
<BONDS>                                            274
                                0
                                          0
<COMMON>                                           127
<OTHER-SE>                                      18,996
<TOTAL-LIABILITY-AND-EQUITY>                    21,187
<SALES>                                            581
<TOTAL-REVENUES>                                   581
<CGS>                                              189
<TOTAL-COSTS>                                      189
<OTHER-EXPENSES>                                 3,086
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 203
<INCOME-PRETAX>                                (2,491)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                            (2,491)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (2,491)
<EPS-PRIMARY>                                    (.20)
<EPS-DILUTED>                                    (.20)
        

</TABLE>


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