OSTEX INTERNATIONAL INC /WA/
S-8, 1998-01-13
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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    AS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION ON JANUARY 12, 1998
                          REGISTRATION NO. 333-_______
============================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549
                               -------------------
                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
                               -------------------
                            OSTEX INTERNATIONAL, INC.
             (Exact Name of Registrant as Specified in Its Charter)
                                   WASHINGTON
         (State or Other Jurisdiction of Incorporation or Organization)
                                   91-1450247
                      (I.R.S. Employer Identification No.)

                        2203 AIRPORT WAY SOUTH, SUITE 400
                            SEATTLE, WASHINGTON 98134
          (Address of Principal Executive Offices, Including Zip Code)

                            OSTEX INTERNATIONAL, INC.
                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN
                                       and
                            OSTEX INTERNATIONAL, INC.
         AMENDED AND RESTATED DIRECTORS' NONQUALIFIED STOCK OPTION PLAN
                            (Full Title of the Plans)
                              ---------------------
      Robert M. Littauer                             COPY TO:
   Ostex International, Inc.                    Stephen M. Graham
2203 Airport Way South, Suite 400                Perkins Coie LLP
  Seattle, Washington 98134               1201 Third Avenue, 40th Floor
      (206) 292-8082                      Seattle, Washington 98101-3099
(Name, Address and Telephone Number,            (206) 583-8888
   Including Area Code, of                     
    Agent for Service)

                      -------------------
<TABLE>
<CAPTION>


                         CALCULATION OF REGISTRATION FEE
============================== ================== ========================== ========================= ====================
                                                      PROPOSED MAXIMUM           PROPOSED MAXIMUM
     TITLE OF SECURITIES         AMOUNT TO BE          OFFERING PRICE           AGGREGATE OFFERING          AMOUNT OF
      TO BE REGISTERED         REGISTERED(3)(4)         PER SHARE(1)                 PRICE(1)           REGISTRATION FEE
============================== ================== ========================== ========================= ====================
============================== ================== ========================== ========================= ====================
<S>                            <C>                <C>                        <C>                       <C>               

COMMON STOCK, $.01 PAR VALUE
PER SHARE(2)
  1994 Stock Option Plan           1,000,000                $2.63                   $2,630,000                     $776

  Directors' Nonqualified
   Stock Option Plan                 100,000                $2.63                   $  263,000                      $78
                                                                                                                  -----
                                                                                                             Total $854
============================== ================== ========================== ========================= ====================

<FN>

(1)  Estimated  solely  for the  purpose of  calculating  the  registration  fee
     pursuant to Rule 457 under the  Securities  Act of 1933,  as  amended.  The
     price per share is estimated to be $2.63,  based on the average of the high
     sales price  ($2.75) and the low sales price  ($2.50) for the  Registrant's
     Common Stock as reported on the Nasdaq National Market on January 6, 1998.
(2)  Includes rights to purchase Series A Junior Participating Preferred Stock,
     par value $.01 per share, associated with the Common Stock.
(3)  Includes an indeterminate number of additional shares that may be necessary
     to adjust  the  number of shares  reserved  for  issuance  pursuant  to the
     Amended and  Restated  1994 Stock  Option Plan and the Amended and Restated
     Directors' Nonqualified Stock Option Plan as the result of any future stock
     dividend,  stock  split,  spin-off,  combination  or  exchange  of  shares,
     recapitalization, merger, consolidation, distribution to stockholders other
     than a normal cash  dividend,  or similar  adjustment  of the  Registrant's
     outstanding Common Stock.
(4)  Prior Form S-8 Registration Statement No. 333-4802, filed by the Registrant
     on  May 6,  1996,  registered  an  aggregate  of  1,000,000  shares  of the
     Registrant's  Common Stock,  of which 750,000  shares were allocated to the
     1994 Stock Option Plan and 250,000  shares were allocated to the Directors'
     Nonqualified Stock Option Plan.

</FN>
</TABLE>



<PAGE>


                                     PART II

                 INFORMATION REQUIRED IN REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

         The following  documents are hereby  incorporated  by reference in this
Registration Statement:

         (a) The  Registrant's  Annual  Report on Form  10-K for the year  ended
December  31,  1996,  filed on March 31, 1997 with the  Securities  and Exchange
Commission (the "Commission") under Section 13(a) of the Securities Exchange Act
of 1934, as amended (the "Exchange  Act"),  which contains  certified  financial
statements for the most recent fiscal year for which such  statements  have been
filed;

         (b) All other reports filed by the Registrant pursuant to Section 13(a)
or 15(d) of the  Exchange  Act since the end of the fiscal  year  covered by the
Annual Report on Form 10-K referred to in (a) above; and

         (c) The description of the  Registrant's  Common Stock contained in the
Registrant's Registration Statement on Form 8-A filed with the Commission on May
6, 1996  (Registration  No.  0-25250)  under  Section 12(g) of the Exchange Act,
including  any  amendments  or reports  filed for the purpose of  updating  such
description.

         All  documents  filed by the  Registrant  pursuant to  Sections  13(a),
13(c),  14 and 15(d) of the  Exchange Act after the date hereof and prior to the
filing  of a  post-effective  amendment,  which  indicates  that the  securities
offered hereby have been sold or which deregisters the securities covered hereby
then remaining unsold, shall also be deemed to be incorporated by reference into
this Registration Statement and to be a part hereof commencing on the respective
dates on which such documents are filed.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         Sections  23B.08.500  through  23B.08.600  of the  Washington  Business
Corporation  Act (the  "WBCA")  authorize a court to award,  or a  corporation's
board of directors to grant,  indemnification to directors,  officers, employees
and agents of the  Registrant and those serving at the  Registrant's  request in
similar positions in any other corporation, partnership, joint venture, trust or
other  enterprise  in terms  sufficiently  broad to permit such  indemnification
under  certain  circumstances  for  liabilities  (including   reimbursement  for
expenses  incurred)  arising under the  Securities  Act of 1933, as amended (the
"Securities Act").  Article 9 of the Registrant's  Amended and Restated Articles
of Incorporation  provides for indemnification of the Registrant's directors and
officers,  to the full extent  permissible  by applicable law as then in effect,
against all  expenses  and  liabilities  (including  any  obligation  to pay any
judgment,  settlement,  penalty,  fine,  including an excise tax  assessed  with
respect to an employee  benefit  plan,  or expense  incurred with respect to the
proceeding,  including  attorney's  fees)  actually and  reasonably  incurred in
connection with any threatened, pending or completed action, suit or proceeding,
whether civil, criminal,  administrative or investigative, and whether formal or
informal, in which the director or officer is, was or is threatened to be made a
party to or is otherwise  involved in by reason of the fact that the director or
officer is or was a director or officer of the Registrant,  or, by reason of the

<PAGE>

fact that,  while a director  or officer of the  Registrant,  such  director  or
officer  is or was  serving  at the  request of the  Registrant  as a  director,
officer,  partner,  trustee,  employee or agent of another  corporation  or of a
partnership,  joint venture,  trust,  employee benefit plan or other enterprise.
The director or officer will not be indemnified for any proceeding  initiated by
such director or officer unless such  proceeding  was, prior to its  initiation,
authorized by the Registrant's Board of Directors or unless the proceeding is to
enforce  the rights of  indemnification.  No  indemnity  may be  provided by the
Registrant for acts or omissions of an indemnified  director finally adjudged to
be  intentional  misconduct  or a knowing  violation of law, for conduct of such
director finally adjudged to be in violation of Section  23B.08.310 of the WBCA,
for any  transaction  with  respect to which it was finally  adjudged  that such
director personally  received a benefit in money,  property or services to which
the  director  was not legally  entitled,  or to the extent the  corporation  is
otherwise prohibited by applicable law from paying such indemnification.

         Section  23B.08.320  of the WBCA  authorizes a  corporation  to limit a
director's liability to the corporation or its shareholders for monetary damages
for acts or omissions as a director,  except in certain circumstances  involving
intentional   misconduct,   self-dealing   or   illegal   corporate   loans   or
distributions,  or any transaction from which the director personally receives a
benefit in money,  property  or  services  to which the  director is not legally
entitled.  Article  8 of the  Registrant's  Amended  and  Restated  Articles  of
Incorporation  provides  for  limitation  of director  liability  to the maximum
extent permitted by the WBCA.

         The  Registrant  also  maintains  an  insurance   policy  insuring  its
directors and officers  against  liability  for certain acts or omissions  while
acting in their official capacity.

ITEM 8.  EXHIBITS

     EXHIBIT
     NUMBER        DESCRIPTION
     ------        ---------------------------------------------------
       5.1         Opinion of Perkins Coie LLP regarding legality of the Common
                   Stock being registered

      23.1         Consent of Arthur Andersen LLP (contained in this Form S-8)

      23.2         Consent of Perkins Coie LLP (included in its Opinion filed 
                   as Exhibit 5.1)

      24.1         Power of Attorney (see Signature Page in this Form S-8)

      99.1         Ostex International, Inc. Amended and Restated 1994 Stock  
                   Option Plan

      99.2         Amendment, dated July 16, 1997, to Ostex International, Inc.
                   Amended and Restated 1994 Stock Option Plan

      99.3         Ostex International, Inc. Amended and Restated Directors' 
                   Nonqualified Stock Option Plan

ITEM 9.  UNDERTAKINGS

A.       The undersigned Registrant hereby undertakes:

         (1) To file, during any period in which offers or sales are being made,
a post-effective amendment to this Registration Statement:

                  (a)      To include any prospectus required by 
Section 10(a)(3) of the Securities Act of 1933, as amended 
(the "Securities Act");


<PAGE>

                  (b) To reflect in the  prospectus  any facts or events arising
after the  effective  date of this  Registration  Statement  (or the most recent
post-effective  amendment  thereof)  which,  individually  or in the  aggregate,
represent a fundamental change in the information set forth in this Registration
Statement; and

                  (c) To include any  material  information  with respect to the
plan of distribution not previously disclosed in this Registration  Statement or
any material change to such information in this Registration Statement;

PROVIDED,  HOWEVER,  that clauses (a)(1)(i) and (a)(1)(ii) above do not apply if
the information  required to be included in a post-effective  amendment by those
paragraphs  is  contained  in periodic  reports  filed with or  furnished to the
Commission  by the  Registrant  pursuant  to Section 13 or Section  15(d) of the
Exchange Act that are incorporated by reference in this Registration Statement.

         (2) That,  for the  purpose  of  determining  any  liability  under the
Securities Act, each such  post-effective  amendment shall be deemed to be a new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

         (3) To remove from registration by means of a post-effective  amendment
any of the securities  being registered that remain unsold at the termination of
the offering.

B.  The  undersigned   Registrant   hereby  undertakes  that,  for  purposes  of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
Registrant's  annual  report  pursuant to Section 13(a) or 15(d) of the Exchange
Act (and, where  applicable,  each filing of an employee  benefits plan's annual
report  pursuant to Section 15(d) of the Exchange Act) that is  incorporated  by
reference  in  this  Registration   Statement  shall  be  deemed  to  be  a  new
registration  statement  relating to the  securities  offered  therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

C. Insofar as indemnification  for liabilities  arising under the Securities Act
may  be  permitted  to  directors,  officers  and  controlling  persons  of  the
Registrant pursuant to the foregoing  provisions,  or otherwise,  the Registrant
has been advised that, in the opinion of the Commission, such indemnification is
against  public  policy as expressed in the  Securities  Act and is,  therefore,
unenforceable.  In the  event  that a claim  for  indemnification  against  such
liabilities  (other than the payment by the  Registrant of expenses  incurred or
paid by a  director,  officer or  controlling  person of the  Registrant  in the
successful  defense of any  action,  suit or  proceeding)  is  asserted  by such
director,  officer or controlling person in connection with the securities being
registered, the Registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction  the  question  of whether  such  indemnification  by it is against
public  policy as  expressed in the  Securities  Act and will be governed by the
final adjudication of such issue.



<PAGE>


                                   SIGNATURES

         Pursuant to the  requirements  of the  Securities  Act, the  Registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the  City of  Seattle,  State of  Washington,  on the 9th day of
January, 1998.

                                   OSTEX INTERNATIONAL, INC.

                                   By  /S/ ROBERT M. LITTAUER
                                     ------------------------------------
                                           Robert M. Littauer
                              Senior Vice President, Finance and Administration
                                  Principal Financial and Accounting Officer

                                POWER OF ATTORNEY

Each person whose signature  appears below hereby  authorizes Robert M. Littauer
and John M. Brenneman,  and each of them, as attorneys-in-fact,  with full power
of  substitution,  to  execute  in  the  name  and on  behalf  of  such  person,
individually  and  in  each  capacity  stated  below,  and  to  file  any or all
amendments (including post-effective amendments) to this Registration Statement,
and to file  the  same  with  all  exhibits  thereto,  and  other  documents  in
connection therewith, with the Commission or any regulatory authority.

Pursuant to the  requirements  of the Securities  Act of 1933, as amended,  this
Registration  Statement  has been signed below by the  following  persons in the
capacities indicated on the 9th day of January, 1998.

              SIGNATURE                             TITLE

- ------------------------------------      --------------------------

      /s/ Thomas A. Bologna               Chief Executive Officer and President,
- ------------------------------------                Director
        Thomas A. Bologna


     /s/ Robert M. Littauer               Senior Vice President, Finance and 
- ------------------------------------              Administration
        Robert M. Littauer            Principal Financial and Accounting Officer


      /s/ Thomas J. Cable                 Chairman of the Board
- ------------------------------------
         Thomas J. Cable

                                          Director
- ------------------------------------
      Elisabeth L. Evans, M.D.

      /s/ David R. Eyre                   Director
- ------------------------------------
         David R. Eyre

     /s/ Fredric J. Feldman               Director
- ------------------------------------
        Fredric J. Feldman

  /s/ Gilbert S. Omenn, M.D., Ph.D.       Director
- ------------------------------------
     Gilbert S. Omenn, M.D., Ph.D.

      /s/ Gregory D. Phelps               Director
- ------------------------------------
        Gregory D. Phelps

     /s/ John H. Trimmer                  Director
- ------------------------------------
        John H. Trimmer



<PAGE>




                                  EXHIBIT 23.1

                    CONSENT OF INDEPENDENT PUBLIC ACCOUNTANTS

          ------------------------------------------------------------


As independent  public  accountants,  we hereby consent to the  incorporation by
reference  in  this  registration  statement  on  Form S 8 of our  report  dated
February 12, 1997 included in Ostex International,  Inc.'s Annual Report on Form
10-K for the year ended  December 31, 1996,  and to all  references  to our firm
included in this registration statement.



/s/   ARTHUR ANDERSEN LLP

Seattle, Washington
January 9, 1998



<PAGE>






                                INDEX TO EXHIBITS

EXHIBIT
NUMBER          DESCRIPTION
- -----------     ------------------------------------------

   5.1          Opinion of Perkins Coie LLP regarding legality of Common Stock 
                being registered

  23.1          Consent of Arthur Andersen LLP (contained in Form S-8)

  23.2          Consent of Perkins Coie LLP (included in its Opinion filed as 
                Exhibit 5.1)

  24.1          Power of Attorney (see Signature Page in Form S-8)

  99.1          Ostex International, Inc. Amended and Restated 1994 Stock 
                Option Plan

  99.2          Amendment, dated July 16, 1997, to Ostex International, Inc. 
                Amended and Restated 1994 Stock Option Plan

  99.3          Ostex International, Inc. Amended and Restated Directors' 
                Nonqualified Stock Option Plan











                                   EXHIBIT 5.1


                                PERKINS COIE LLP
          1201 THIRD AVENUE, 40TH FLOOR, SEATTLE, WASHINGTON 98101-3099
               TELEPHONE: (206) 583-8888 FACSIMILE: (206) 583-8500



                                               January 9, 1998



Ostex International, Inc.
2203 Airport Way South, Suite 400
Seattle, Washington  98134

         Re:      Registration Statement on Form S-8 of Shares of Common Stock,
                  Par Value $.01 per Share, of Ostex International, Inc.

Ladies and Gentlemen:

         We have acted as counsel to you in connection with the preparation of a
Registration  Statement  on Form S-8 (the  "Registration  Statement")  under the
Securities  Act of 1933,  as amended (the "Act"),  which you are filing with the
Securities and Exchange  Commission  with respect to 1,100,000  shares of Common
Stock,  $0.01  par value per share  (the  "Shares"),  1,000,000  of which may be
issued pursuant to the Ostex International, Inc. Amended and Restated 1994 Stock
Option  Plan  and  100,000  of  which  may  be  issued  pursuant  to  the  Ostex
International,  Inc. Amended and Restated  Directors'  Nonqualified Stock Option
Plan (together,  the "Plans").  We have examined the Registration  Statement and
such documents and records of the Company and other  documents as we have deemed
necessary  for the  purpose of this  opinion.  In giving  this  opinion,  we are
assuming the authenticity of all instruments  presented to us as originals,  the
conformity with originals of all  instruments  presented to us as copies and the
genuineness of all signatures.

         Based upon and subject to the foregoing, we are of the opinion that any
original issuance Shares that may be issued pursuant to the Plans have been duly
authorized and that, upon the due execution by the Company and the  registration
by its registrar of such Shares,  issuance  thereof by the Company in accordance
with the terms of the  Plans,  and the  receipt  of  consideration  therefor  in
accordance  with the terms of the Plans,  such  Shares  will be validly  issued,
fully paid and nonassessable.

         We hereby  consent to the filing of this  opinion as Exhibit 5.1 to the
Registration  Statement.  In giving such consent, we do not admit that we are in
the category of persons whose consent is required under Section 7 of the Act.

                                Very truly yours,

                                  PERKINS COIE










                                  EXHIBIT 99.1


                            OSTEX INTERNATIONAL, INC.

                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN


         This 1994 Stock  Option  Plan (the  "Plan")  provides  for the grant of
options to acquire shares of Common Stock,  $.01 par value (the "Common Stock"),
of Ostex International,  Inc., a Washington  corporation (the "Company").  Stock
options  granted  under this Plan that qualify under Section 422 of the Internal
Revenue Code of 1986, as amended (the  "Code"),  are referred to in this Plan as
"Incentive Stock Options." Incentive Stock Options and stock options that do not
qualify under Section 422 of the Code  ("Non-Qualified  Stock Options")  granted
under this Plan are referred to as "Options."

1.       PURPOSES

         The  purposes  of this Plan are to retain  the  services  of valued key
employees  and  consultants  of the Company,  and such other persons as the Plan
Administrator shall select in accordance with Section 3 below, to encourage such
persons  to  acquire a greater  proprietary  interest  in the  Company,  thereby
strengthening  their incentive to achieve the objectives of the  shareholders of
the  Company,  and to  serve  as an aid  and  inducement  in the  hiring  of new
employees, consultants and other persons selected by the Plan Administrator.

2.       ADMINISTRATION

         This  Plan  shall be  administered  by the  Board of  Directors  of the
Company (the "Board"), except that the Board may, in its discretion, establish a
committee  composed of members of the Board or other persons to administer  this
Plan,  which committee (the  "Committee")  may be an executive,  compensation or
other  committee,  including a separate  committee  especially  created for this
purpose. The Committee shall have such of the powers and authority vested in the
Board  hereunder  as the  Board  may  delegate  to it  (including  the power and
authority to interpret any provision of this Plan or of any Option). The members
of any such Committee shall serve at the discretion of the Board.  The Board, or
the Committee if one has been  established by the Board, are referred to in this
Plan as the "Plan Administrator." Following registration of any of the Company's
securities  under Section 12 of the Securities  Exchange Act of 1934, as amended
(the  "Exchange   Act"),  no  person  shall  serve  as  a  member  of  the  Plan
Administrator  if his or her service would disqualify this Plan from eligibility
under  Securities and Exchange  Commission  Rule 16b-3,  as amended from time to
time, or any successor rule or regulatory  requirement;  PROVIDED, that the Plan
Administrator  shall consist of at least the minimum number of persons  required
by Securities and Exchange  Commission Rule 16b-3, as amended,  or any successor
rule or regulatory  requirement.  If, and so long as, the Company has a class of
equity securities  registered under Section 12 of the Exchange Act, the Board of
Directors in  determining  the  membership  of any such  committee  shall,  with
respect to option grants to any persons  subject to or likely to become  subject
to Section 16 of the Exchange  Act,  give due  consideration  to the  provisions
regarding (a) "outside  directors" as contemplated by Section 162(m) of the Code
and (b) "nonemployee directors" as contemplated by Rule 16b-3 under the Exchange
Act.

         Subject to the  provisions  of this Plan,  and with a view to effecting
its purpose,  the Plan Administrator shall have sole authority,  in its absolute
discretion,  to: (a) construe and interpret this Plan; (b) define the terms used

<PAGE>

in this Plan; (c) prescribe, amend and rescind rules and regulations relating to
this Plan;  (d)  correct  any  defect,  supply any  omission  or  reconcile  any
inconsistency  in this Plan; (e) determine the individuals to whom Options shall
be granted  under this Plan and whether the Option is an Incentive  Stock Option
or a  Non-Qualified  Stock  Option;  (f)  determine  the  time or times at which
Options shall be granted under this Plan;  (g) determine the number of shares of
Common Stock  subject to each Option,  the  exercise  price of each Option,  the
duration  of each  Option  and the  times  at which  each  Option  shall  become
exercisable;  (h) determine all other terms and  conditions of Options;  and (i)
make all other  determinations  necessary or advisable for the administration of
this Plan. All decisions,  determinations and  interpretations  made by the Plan
Administrator  shall be binding and conclusive on all  participants in this Plan
and on their legal representatives, heirs and beneficiaries.

3.       ELIGIBILITY

         Incentive  Stock Options may be granted to any  individual  who, at the
time the  Option is  granted,  is an  employee  of the  Company  or any  Related
Corporation  (as defined  below),  including  employees who are directors of the
Company  ("Employees").  Non-Qualified Stock Options may be granted to Employees
and to such other persons other than directors who are not Employees as the Plan
Administrator  shall  select.   Options  may  be  granted  in  substitution  for
outstanding  Options of  another  corporation  in  connection  with the  merger,
consolidation,  acquisition of property or stock or other reorganization between
such other corporation and the Company or any subsidiary of the Company. Options
also may be granted in exchange for outstanding  Options.  Any person to whom an
Option is granted under this Plan is referred to as an "Optionee."

         As used in this Plan, the term "Related Corporation," when referring to
a subsidiary corporation, shall mean any corporation (other than the Company) in
an unbroken chain of corporations  beginning with the Company if, at the time of
the  granting  of the  Option,  each of the  corporations  other  than  the last
corporation in the unbroken chain owns stock  possessing  fifty percent (50%) or
more of the total  combined  voting  power of all classes of stock of one of the
other  corporations in such chain. When referring to a parent  corporation,  the
term "Related  Corporation"  shall mean any corporation (other than the Company)
in an unbroken chain of corporations  ending with the Company if, at the time of
granting of the Option,  each of the  corporations  other than the Company  owns
stock  possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock of one of the other corporations in such chain.

4.       STOCK

         Subject to approval of the Plan by shareholders of the Company, options
to  purchase a maximum  of  1,750,000  shares of the  Company's  authorized  but
unissued, or required,  Common Stock may be issued pursuant to the Plan, subject
to adjustment as provided in Section 5.13(a) below; PROVIDED, that any shares of
Common Stock received or withheld by the Company as payment for shares of Common
Stock purchased upon exercise of Options  pursuant to Section 5.9 below shall be
added to the  number of such  shares as to which  Options  may be  granted.  The
number of shares  with  respect to which  Options  may be granted  hereunder  is
subject to adjustment as set forth in Section 5.13 below.  In the event that any
outstanding Option expires or is terminated for any reason, the shares of Common
Stock allocable to the  unexercised  portion of such Option may again be subject
to an  Option to the same  Optionee  or to a  different  person  eligible  under
Section 3 above.


<PAGE>

5.       TERMS AND CONDITIONS OF OPTIONS

         Each Option  granted  under this Plan shall be  evidenced  by a written
agreement approved by the Plan  Administrator (the "Agreement").  Agreements may
contain such additional provisions, not inconsistent with this Plan, as the Plan
Administrator  in its  discretion  may deem  advisable.  All Options  also shall
comply with the following requirements:

         5.1      NUMBER OF SHARES AND TYPE OF OPTION

         Each  Agreement  shall  state the  number of shares of Common  Stock to
which it pertains  and whether the Option is intended to be an  Incentive  Stock
Option or a Non-Qualified Stock Option. In the absence of action to the contrary
by the Plan Administrator in connection with the grant of an Option, all Options
shall  be  Non-Qualified   Stock  Options.   The  aggregate  fair  market  value
(determined at the Date of Grant, as defined below) of the stock with respect to
which Incentive Stock Options are exercisable for the first time by the Optionee
during any calendar year (granted under this Plan and all other  Incentive Stock
Option plans of the Company, a Related Corporation or a predecessor corporation)
shall  not  exceed  such  limit  as may be  prescribed  by the Code as it may be
amended from time to time.  Any Option which  exceeds the annual limit shall not
be void but rather shall be a Non-Qualified Stock Option.

                  (a) LIMITATION ON NUMBER OF SHARES UNDERLYING OPTIONS. Subject
to  adjustment  from time to time as  provided in Section  5.13 below,  the Plan
Administrator  shall not grant  options to any person in any one fiscal  year of
the Company in an amount  that  exceeds,  in the  aggregate,  200,000  shares of
Common Stock.  This limitation shall be applied in a manner  consistent with the
requirements  of, and only to the  extent  required  for  compliance  with,  the
exclusion from the limitation on  deductibility  of  compensation  under Section
162(m) of the Code.

         5.2      DATE OF GRANT

         Each Agreement shall state the date the Plan  Administrator  has deemed
to be the  effective  date of the Option for purposes of this Plan (the "Date of
Grant").

         5.3      OPTION PRICE

         Each Agreement shall state the price per share of Common Stock at which
it is exercisable.  The exercise price shall be fixed by the Plan  Administrator
at whatever  price the Plan  Administrator  may determine in the exercise of its
sole  discretion;  PROVIDED,  that the per share  exercise  price for any Option
granted  following the effective  date of  registration  of any of the Company's
securities under Section 12 of the Securities  Exchange Act of 1934 shall not be
less than the fair  market  value per share of the  Common  Stock at the Date of
Grant as determined by the Plan  Administrator in good faith;  PROVIDED FURTHER,
that the per share  exercise  price for an  Incentive  Stock Option shall not be
less than the fair  market  value per share of the  Common  Stock at the Date of
Grant as determined by the Plan  Administrator in good faith;  PROVIDED FURTHER,
that with respect to Incentive Stock Options granted to greater-than-ten percent
(>10%)  shareholders  of the Company (as  determined  with  reference to Section
424(d) of the Code),  the  exercise  price per share  shall not be less than one
hundred  ten  percent  (110%) of the fair  market  value per share of the Common
Stock at the Date of Grant; and, PROVIDED FURTHER,  that Incentive Stock Options
granted in  substitution  for  outstanding  Options of  another  corporation  in
connection with the merger,  consolidation,  acquisition of property or stock or

<PAGE>

other  reorganization  involving such other  corporation  and the Company or any
subsidiary  of the  Company may be granted  with an exercise  price equal to the
exercise price for the substituted Option of the other  corporation,  subject to
any adjustment  consistent with the terms of the  transaction  pursuant to which
the substitution is to occur.

         5.4      DURATION OF OPTIONS

         At the time of the grant of the Option,  the Plan  Administrator  shall
designate,  subject to Section  5.7 below,  the  expiration  date of the Option,
which  date shall not be later than ten (10) years from the Date of Grant in the
case of Incentive  Stock  Options;  PROVIDED,  that the  expiration  date of any
Incentive Stock Option granted to a greater-than-ten  percent (>10%) shareholder
of the Company (as  determined  with  reference  to Section  424(d) of the Code)
shall not be later than five (5) years from the Date of Grant. In the absence of
action to the contrary by the Plan Administrator in connection with the grant of
a  particular  Option,  and  except in the case of  Incentive  Stock  Options as
described above, all Options granted under this Plan shall expire ten (10) years
from the Date of Grant.

         5.5      VESTING SCHEDULE

         No  Option  shall be  exercisable  until  it has  vested.  The  vesting
schedule for each Option shall be  specified  by the Plan  Administrator  at the
time of grant of the Option;  PROVIDED, that if no vesting schedule is specified
at the time of grant, the Option shall vest according to the following schedule:

                                            PERCENTAGE OF
         NUMBER OF YEARS                   TOTAL OPTION TO
     FOLLOWING DATE OF GRANT               BE EXERCISABLE
   ----------------------------         --------------------
                1                               20%
                2                               40%
                3                               60%
                4                               80%
                5                              100%

         5.6      ACCELERATION OF VESTING

         The vesting of one or more  outstanding  Options may be  accelerated by
the Plan  Administrator  at such times and in such amounts as it shall determine
in its sole  discretion.  If an Employee  Optionee's  employment  terminates  by
reason of death or Disability (as defined in Section 5.7 below), any Option held
by such Employee Optionee who has been  Continuously  Employed by the Company or
Related Corporation for a minimum of two (2) years shall become fully vested and
exercisable  and may  thereafter be exercised  during the term of the Option set
forth in Section 5.7 below.  "Continuously  Employed"  shall mean the absence of
any  interruption  or termination  of service.  Continuous  Employment  with the
Company or Related  Corporation shall not be considered  interrupted in the case
of sick  leave,  military  leave or any other  leave of absence  approved by the
Company or Related  Corporation or in the case of transfers between locations of
the Company or between the Company,  Related  Corporations or their  successors,
provided  that the  Optionee  continues  to be an employee of the Company or any
Related Corporation.  The vesting of Options also shall be accelerated under the
circumstances described in Sections 5.13 and 5.14 below.


<PAGE>

         5.7      TERM OF OPTION

         Vested Options shall terminate, to the extent not previously exercised,
upon the occurrence of the first of the following events:  (i) the expiration of
the Option,  as designated by the Plan  Administrator in accordance with Section
5.4  above;  (ii)  the  expiration  of  ninety  (90)  days  from  the date of an
Optionee's  termination  of  employment  or  contractual  relationship  with the
Company or any Related Corporation for any reason whatsoever other than death or
Disability  (as defined  below)  unless,  in the case of a  Non-Qualified  Stock
Option, the exercise period is extended by the Plan  Administrator  until a date
not later than the expiration date of the Option; or (iii) the expiration of one
(1) year  from (A) the date of death  of the  Optionee  or (B)  cessation  of an
Optionee's  employment or contractual  relationship  by reason of Disability (as
defined below) unless, in the case of a Non-Qualified Stock Option, the exercise
period is  extended  by the Plan  Administrator  until a date not later than the
expiration  date of the  Option.  If an  Optionee's  employment  or  contractual
relationship  is terminated by death,  any Option held by the Optionee  shall be
exercisable  only by the person or persons to whom such Optionee's  rights under
such  Option  shall pass by the  Optionee's  will or by the laws of descent  and
distribution  of the state or county of the  Optionee's  domicile at the time of
death.  "Disability"  shall  mean  that a person  is  unable  to  engage  in any
substantial gainful activity by reason of any medically determinable physical or
mental  impairment that can be expected to result in death or that has lasted or
can be  expected  to last for a  continuous  period of not less than twelve (12)
months. The Plan Administrator  shall determine whether an Optionee has incurred
a  Disability  on  the  basis  of  medical  evidence   acceptable  to  the  Plan
Administrator.  Upon making a determination of Disability,  the Committee shall,
for purposes of the Plan,  determine  the date of an Optionee's  termination  of
employment or contractual relationship.

         Unless  accelerated  in  accordance  with  Section 5.6 above,  unvested
Options  shall  terminate  immediately  upon  termination  of  employment of the
Optionee  by  the  Company  for  any  reason  whatsoever,   including  death  or
Disability.

         If,  in  the  case  of  an  Incentive   Stock  Option,   an  Optionee's
relationship with the Company changes (e.g., from an Employee to a non-Employee,
such as a  consultant),  such change shall not  constitute a  termination  of an
Optionee's employment with the Company but rather the Optionee's Incentive Stock
Option.  For  purposes of this Section 5.7,  transfer of  employment  between or
among  the  Company  and/or  any  Related  Corporation  shall  not be  deemed to
constitute  a  termination  of  employment  with  the  Company  or  any  Related
Corporation.  For purposes of this Section  5.7,  employment  shall be deemed to
continue while the Optionee is on military leave,  sick leave or other bona fide
leave of  absence  (as  determined  by the Plan  Administrator).  The  foregoing
notwithstanding,  with respect to Incentive Stock Options,  employment shall not
be deemed to continue  beyond the first  ninety (90) days of such leave,  unless
the Optionee's reemployment rights are guaranteed by statute or by contract.

         5.8      EXERCISE OF OPTIONS

         Options shall be exercisable,  either all or in part, at any time after
vesting,  until  termination;  PROVIDED,  that after  registration of any of the
Company's  securities under Section 12 of the Exchange Act, Optionee must comply
with the six (6) month  holding  period  requirements  of  Section  16(b) of the
Exchange Act and Rule 16b-3 thereunder.  If less than all of the shares included
in the  vested  portion  of any  Option  are  purchased,  the  remainder  may be
purchased at any subsequent  time prior to the expiration of the Option term. No
portion of any Option for less than fifty (50) shares (as  adjusted  pursuant to
Section 5.13 below) may be exercised;  PROVIDED,  that if the vested  portion of
any Option is less than fifty (50) shares,  it may be exercised  with respect to
all shares for which it is vested.  Only whole shares may be issued  pursuant to
an Option,  and to the extent that an Option covers less than one (1) share,  it
is unexercisable.  Options or portions thereof may be exercised by giving to the

<PAGE>

Company an executed  notice of election to exercise,  which notice shall specify
the  number of shares to be  purchased,  and be  accompanied  by  payment in the
amount of the aggregate exercise price for the Common Stock so purchased,  which
payment shall be in the form  specified in Section 5.9 below.  The Company shall
not be obligated to issue,  transfer or deliver a certificate of Common Stock to
any Optionee,  or to his personal  representative,  until the aggregate exercise
price  has been  paid for all  shares  for  which  the  Option  shall  have been
exercised and adequate  provision has been made by the Optionee for satisfaction
of any tax withholding  obligations  associated  with such exercise.  During the
lifetime of an Optionee, Options are exercisable only by the Optionee.

         5.9      PAYMENT UPON EXERCISE OF OPTION

         Upon the exercise of any Option,  the aggregate exercise price shall be
paid to the Company in cash or by  certified or  cashier's  check.  In addition,
upon  approval of the Plan  Administrator,  an  Optionee  may pay for all or any
portion of the aggregate  exercise price by (i) delivering to the Company shares
of Common Stock  previously  held by such Optionee,  (ii) having shares withheld
from the amount of shares of Common Stock to be received by the Optionee,  (iii)
delivering an irrevocable subscription agreement obligating the Optionee to take
and pay for the shares of Common  Stock to be  purchased  within one (1) year of
the date of such exercise or (iv) complying with any other payment mechanisms as
the Plan Administrator may approve from time to time. The shares of Common Stock
received  or  withheld  by the  Company  as payment  for shares of Common  Stock
purchased  upon the  exercise of Options  shall have a fair market  value at the
date  of  exercise  (as  determined  by the  Plan  Administrator)  equal  to the
aggregate  exercise  price (or portion  thereof) to be paid by the Optionee upon
such exercise.

         5.10     RIGHTS AS A SHAREHOLDER

         An Optionee  shall have no rights as a shareholder  with respect to any
shares covered by an Option until such Optionee  becomes a record holder of such
shares,  irrespective  of whether  such  Optionee  has given notice of exercise.
Subject to the  provisions  of  Sections  5.13 and 5.14 below,  no rights  shall
accrue to an Optionee and no  adjustments  shall be made on account of dividends
(ordinary or  extraordinary,  whether in cash,  securities or other property) or
distributions  or other rights  declared on, or created in, the Common Stock for
which the record date is prior to the date the Optionee  becomes a record holder
of the shares of Common  Stock  covered by the Option,  irrespective  of whether
such Optionee has given notice of exercise.

         5.11     TRANSFER OF OPTION

         Options granted under this Plan and the rights and privileges conferred
by this Plan may not be  transferred,  assigned,  pledged or hypothecated in any
manner  (whether  by  operation  of law or  otherwise)  other than by will or by
applicable  laws of descent  and  distribution,  as defined by the Code,  or the
Employee   Retirement   Income  Security  Act,  or  the  rules  and  regulations
thereunder,  and  shall not be  subject  to  execution,  attachment  or  similar
process. Upon any attempt to transfer,  assign, pledge, hypothecate or otherwise
dispose  of any  Option  or of any  right or  privilege  conferred  by this Plan
contrary to the provisions  hereof,  or upon the sale, levy or any attachment or
similar  process upon the rights and  privileges  conferred  by this Plan,  such
Option shall thereupon terminate and become null and void.


<PAGE>

         5.12     SECURITIES REGULATION AND TAX WITHHOLDING

                  5.12.1  Shares  shall not be issued with  respect to an Option
unless the  exercise of such Option and the issuance and delivery of such shares
shall comply with all relevant provisions of law, including, without limitation,
any applicable  state  securities  laws, the Securities Act of 1933, as amended,
the  Exchange  Act, as amended,  the rules and  regulations  thereunder  and the
requirements  of any stock  exchange  upon which such shares may then be listed,
and such  issuance  shall be further  subject to the approval of counsel for the
Company  with  respect to such  compliance,  including  the  availability  of an
exemption  from  registration  for the  issuance  and sale of such  shares.  The
inability of the Company to obtain from any regulatory body the authority deemed
by the Company to be  necessary  for the lawful  issuance and sale of any shares
under this Plan, or the unavailability of an exemption from registration for the
issuance  and sale of any shares under this Plan,  shall  relieve the Company of
any liability with respect to the nonissuance or sale of such shares.

         As a condition to the exercise of an Option, the Plan Administrator may
require  the  Optionee to  represent  and warrant in writing at the time of such
exercise that the shares are being purchased only for investment and without any
then-present  intention to sell or distribute such shares.  At the option of the
Plan  Administrator,  a stop-transfer order against such shares may be placed on
the stock books and records of the  Company,  and a legend  indicating  that the
stock may not be pledged,  sold or  otherwise  transferred  unless an opinion of
counsel is  provided  stating  that such  transfer  is not in  violation  of any
applicable law or regulation,  may be stamped on the  certificates  representing
such  shares  in  order to  assure  an  exemption  from  registration.  The Plan
Administrator also may require such other documentation as may from time to time
be necessary to comply with federal and state  securities  laws. THE COMPANY HAS
NO  OBLIGATION  TO  UNDERTAKE  REGISTRATION  OF  OPTIONS  OR THE SHARES OF STOCK
ISSUABLE UPON THE EXERCISE OF OPTIONS.

                  5.12.2 As a condition  to the  exercise of any Option  granted
under  this  Plan,  the  Optionee  shall  make  such  arrangements  as the  Plan
Administrator  may require for the  satisfaction of any federal,  state or local
withholding tax obligations that may arise in connection with such exercise.

                  5.12.3 The issuance,  transfer or delivery of  certificates of
Common  Stock  pursuant  to the  exercise  of  Options  may be  delayed,  at the
discretion of the Plan Administrator,  until the Plan Administrator is satisfied
that the applicable  requirements  of the federal and state  securities laws and
the withholding provisions of the Code have been met.

         5.13     STOCK DIVIDEND, REORGANIZATION OR LIQUIDATION

                  5.13.1 If (i) the  Company  shall at any time be involved in a
transaction described in Section 424(a) of the Code (or any successor provision)
or any "corporate transaction" described in the regulations thereunder, (ii) the
Company shall declare a dividend payable in, or shall subdivide or combine,  its
Common Stock or (iii) any other event with  substantially  the same effect shall
occur, then the Plan Administrator  shall  proportionately  adjust the number of
shares of Common  Stock  authorized  for  issuance  under this Plan  pursuant to
Section 4 above, and shall further  proportionately  adjust the number of shares
of Common Stock and/or the exercise  price per share with respect to each Option
then  outstanding  so as to preserve  the rights of the  Optionee  substantially
proportionate  to the rights of the  Optionee  prior to such event,  all without
further  action  on the  part of the  Plan  Administrator,  the  Company  or the
Company's shareholders.


<PAGE>

                  5.13.2 If the Company is  liquidated  or  dissolved,  the Plan
Administrator shall allow the holders of any outstanding Options to exercise all
or any part of the unvested portion of the Options held by them; PROVIDED,  that
such Options must be exercised  prior to the effective date of such  liquidation
or  dissolution.  If the Option  holders do not exercise  their Options prior to
such effective date, each outstanding Option shall terminate as of the effective
date of the liquidation or dissolution.

                  5.13.3 The  foregoing  adjustments  in the  shares  subject to
Options  shall  be  made  by  the  Plan  Administrator,   or  by  any  successor
administrator  of this Plan,  or by the  applicable  terms of any  assumption or
substitution document.

                  5.13.4 The grant of an Option  shall not affect in any way the
right  or  power  of  the  Company  to  make   adjustments,   reclassifications,
reorganizations  or changes  of its  capital or  business  structure,  to merge,
consolidate or dissolve,  to liquidate or to sell or transfer all or any part of
its business or assets.

         5.14     CHANGE IN CONTROL; DECLARATION OF EXTRAORDINARY DIVIDEND

                  5.14.1   CHANGE IN CONTROL

         If at any time there is a Change in Control (as  defined  below) of the
Company,  all Options shall  accelerate and become fully vested and  immediately
exercisable for the duration of the Option term. For purposes of this Subsection
5.14.1, "Change in Control" shall mean either one of the following: (i) When any
"person,"  as such term is used in sections  13(d) and 14(d) of the Exchange Act
(other than a shareholder  of the Company on the date of this Plan, the Company,
a Subsidiary or an employee  benefit plan of the Company,  including any trustee
of such plan  acting as  trustee)  becomes,  after  the date of this  Plan,  the
"beneficial  owner" (as defined in Rule 13d-3 under the Exchange Act),  directly
or indirectly,  of securities of the Company representing fifty percent (50%) or
more of the combined voting power of the Company's then outstanding  securities;
or (ii) the  occurrence of a transaction  requiring  shareholder  approval,  and
involving the sale of all or  substantially  all of the assets of the Company or
the merger of the Company with or into another corporation.

                  5.14.2   DECLARATION OF EXTRAORDINARY DIVIDEND

         If at any time the  Company  declares  an  Extraordinary  Dividend  (as
defined below),  all Options shall  accelerate and thereupon become fully vested
and immediately exercisable for the duration of the Option term. For purposes of
this  Subsection  5.14.2,  "Extraordinary  Dividend"  shall mean a cash dividend
payable to  holders of record of the Common  Stock in an amount in excess of ten
percent (10%) of the then fair market value of the Company's  Common Stock.  The
fair market  value of the  Company's  Common Stock shall be  determined  in good
faith by the Board.

6.       EFFECTIVE DATE; TERM

         This Plan shall be  effective  as of the closing of the initial  public
offering  of  securities  of the  Company  under  the  Securities  Act of  1933.
Incentive  Stock Options may be granted by the Plan  Administrator  from time to
time thereafter  until ten (10) years after such approval.  Non-Qualified  Stock
Options may be granted  until this Plan is  terminated  by the Board in its sole
discretion.  Termination  of this Plan shall not  terminate  any Option  granted
prior to such termination.


<PAGE>

7.       NO OBLIGATIONS TO EXERCISE OPTION

         The grant of an Option shall impose no obligation  upon the Optionee to
exercise such Option.

8.       NO RIGHT TO OPTIONS OR TO EMPLOYMENT

         The grant of any Options  under this Plan shall be  exclusively  within
the  discretion of the Plan  Administrator,  and nothing  contained in this Plan
shall be  construed  as giving any person  any right to  participate  under this
Plan.  The Plan  shall not  confer on any  Optionee  any right  with  respect to
continuation of any employment or contractual  relationship  with the Company or
any Related  Corporation,  nor shall it interfere in any way with the  Company's
or, where applicable,  a Related Corporation's right to terminate any Optionee's
employment  or  contractual  relationship  at any  time,  which  right is hereby
reserved.

9.       APPLICATION OF FUNDS

         The  proceeds  received  by the Company  from the sale of Common  Stock
issued  upon  the  exercise  of  Options  shall be used  for  general  corporate
purposes, unless otherwise directed by the Board.

10.      INDEMNIFICATION OF PLAN ADMINISTRATOR

         In addition  to all other  rights of  indemnification  they may have as
members of the Board,  members of the Plan Administrator shall be indemnified by
the Company for all reasonable  expenses and  liabilities of any type or nature,
including  reasonable  attorneys' fees,  incurred in connection with any action,
suit or  proceeding to which they or any of them are a party by reason of, or in
connection  with,  this Plan or any Option  granted under this Plan, and against
all amounts paid by them in settlement thereof (provided that such settlement is
approved by independent  legal counsel  selected by the Company),  except to the
extent that such  expenses  relate to matters for which it is adjudged that such
Plan  Administrator  member is liable for  willful  misconduct;  PROVIDED,  that
within  fifteen  (15) days after the  institution  of any such  action,  suit or
proceeding,  the Plan  Administrator  member involved therein shall, in writing,
notify the Company of such action,  suit or proceeding,  so that the Company may
have the opportunity to make appropriate arrangements to prosecute or defend the
same.

11.      AMENDMENT OF PLAN

         The Plan  Administrator  may, at any time,  modify,  amend or terminate
this Plan and Options granted under this Plan,  including,  without  limitation,
such  modifications  or amendments as are necessary to maintain  compliance with
applicable  statutes,  rules or  regulations;  PROVIDED,  that no amendment with
respect  to an  outstanding  Option  shall  be made  over the  objection  of the
Optionee thereof; and PROVIDED FURTHER,  that, following  registration of any of
the Company's  securities  under Section 12 of the Exchange Act, the approval of
the holders of a majority of the Company's  outstanding shares of voting capital
stock  represented at a meeting at which a quorum is present is required  within
twelve (12) months before or after the adoption by the Plan Administrator of any
amendment  that will permit the granting of Options to a class of persons  other
than those  currently  eligible to receive Options under this Plan or that would
cause this Plan to no longer comply with Securities and Exchange Commission Rule
16b-3,  as amended,  or any  successor  rule or other  regulatory  requirements.
Without  limiting the generality of the foregoing,  the Plan  Administrator  may
modify grants to persons who are eligible to receive Options under this Plan who
are  foreign  nationals  or  employed  outside  the United  States to  recognize
differences in local law, tax policy or custom.

         Approved by the Company's Board of Directors,  as Amended and Restated,
as of April 10, 1997:

         Approved by the Company's  shareholders,  as Amended and  Restated,  on
June 2, 1997:










                                  EXHIBIT 99.2

                          AMENDMENT DATED JULY 16, 1997

                                       TO

                            OSTEX INTERNATIONAL, INC.

                   AMENDED AND RESTATED 1994 STOCK OPTION PLAN


         The Ostex International, Inc. Amended and Restated 1994 Stock Option 
Plan (the "Plan") is hereby amended as follows:

         1.       Section 4 is amended by adding the following sentence at the 
                  end of the section:

                           "Notwithstanding the foregoing,  the aggregate number
                           of shares that may be issued  under  Incentive  Stock
                           Options shall not exceed 1,750,000."

         2.       The first sentence of Section 5.1(a) shall be amended to read
                  as follows:

                           "Subject to adjustment  from time to time as provided
                           in Section 5.13 below, the Plan  Administrator  shall
                           not grant  options  to any  person in any one  fiscal
                           year of the Company in an amount that exceeds, in the
                           aggregate,  300,000  shares of Common  Stock,  except
                           that the amount may be up to, but not exceed,  in the
                           aggregate,  800,000  shares of  Common  Stock for any
                           newly  hired  person  in any one  fiscal  year of the
                           Company."

         3.       The second sentence of Section 5.9 shall be amended to read 
                  as follows:

                           "In   addition,   unless   the   Plan   Administrator
                           determines  otherwise,  in its  sole  discretion,  an
                           Optionee  may  pay  for  all  or any  portion  of the
                           aggregate exercise price by delivering to the Company
                           shares  of  Common  Stock  previously  held  by  such
                           Optionee  for at least six (6) months (or any shorter
                           period  necessary to avoid a charge to the  Company's
                           earnings  for  financial  reporting  purposes).  Upon
                           approval of the Plan  Administrator,  an Optionee may
                           also  pay for  all or any  portion  of the  aggregate
                           exercise  price  by  (i)  delivering  an  irrevocable
                           subscription  agreement  obligating  the  Optionee to
                           take and pay for the  shares  of  Common  Stock to be
                           purchased  within  one (1)  year of the  date of such
                           exercise  or (ii)  complying  with any other  payment
                           mechanisms  the Plan  Administrator  may approve from
                           time to time.  The shares of Common Stock received by
                           the  Company  as payment  for shares of Common  Stock
                           purchased  upon the exercise of Options  shall have a
                           fair  market  value  at  the  date  of  exercise  (as
                           determined  by the Plan  Administrator)  equal to the
                           aggregate  exercise price (or portion  thereof) to be
                           paid by the Optionee upon such exercise."
<PAGE>

         4.       Section 5.14.1 shall be amended to read as follows:

                           "Except as otherwise provided in any Agreement for an
                           Option granted prior to July 31, 1997, if at any time
                           there is a Change in Control  (as  defined  below) of
                           the Company,  all Options shall accelerate and become
                           fully  vested  and  immediately  exercisable  for the
                           duration of the Option term.  All such Options  shall
                           terminate and cease to remain outstanding immediately
                           following the  consummation of the Change in Control,
                           except to the extent  such  Options  are assumed by a
                           successor  corporation  incident  to  the  Change  in
                           Control  or in the  event of a Change in  Control  as
                           defined in clause (i) of the following sentence.  For
                           purposes  of  this  Subsection  5.14.1,   "Change  in
                           Control" shall mean either one of the following:  (i)
                           when any  "person,"  as such term is used in sections
                           13(d) and 14(d) of the  Exchange  Act  (other  than a
                           shareholder  of the Company on the date of this Plan,
                           the Company, a Subsidiary or an employee benefit plan
                           of the  Company,  including  any trustee of such plan
                           acting as  trustee)  becomes,  after the date of this
                           Plan,  the  "beneficial  owner"  (as  defined in Rule
                           13d-3   under  the   Exchange   Act),   directly   or
                           indirectly, of securities of the Company representing
                           fifty  percent  (50%) or more of the combined  voting
                           power of the Company's then  outstanding  securities;
                           or (ii) the  occurrence  of a  transaction  requiring
                           shareholder  approval,  and involving the sale of all
                           or substantially  all of the assets of the Company or
                           the  merger  of the  Company  with  or  into  another
                           corporation."

         The date of the adoption of such  amendments  by the Board of Directors
of the corporation is July 16, 1997.

         The effective date of such amendments  shall be July 16, 1997, the date
of adoption by the Board.





                                  EXHIBIT 99.3


                            OSTEX INTERNATIONAL, INC.

         AMENDED AND RESTATED DIRECTORS' NONQUALIFIED STOCK OPTION PLAN

         This Nonqualified Stock Option Plan (the "Plan") provides for the grant
of options  to  acquire  shares of Common  Stock,  $.01 par value  (the  "Common
Stock"), of Ostex International, Inc., a Washington corporation (the "Company").

1.       PURPOSE

         The  purpose of this Plan is to  compensate  certain  directors  of the
Company (the "Optionees" or "Optionee").

2.       ELIGIBILITY

         Persons  eligible  to  receive  options  under  this Plan  shall be all
directors  of the Company who are not  otherwise  employed by the Company or any
Related Corporation,  as defined below (the "Directors" or "Director").  Options
may be granted in substitution for outstanding Options of another corporation in
connection with the merger,  consolidation,  acquisition of property or stock or
other  reorganization  between  such other  corporation  and the  Company or any
subsidiary  of  the  Company.  Options  also  may be  granted  in  exchange  for
outstanding Options.

         As used in this Plan, the term "Related Corporation," when referring to
a subsidiary corporation, shall mean any corporation (other than the Company) in
an unbroken chain of corporations  beginning with the Company if, at the time of
the  granting  of the  Option,  each of the  corporations  other  than  the last
corporation in the unbroken chain owns stock  possessing  fifty percent (50%) or
more of the total  combined  voting  power of all classes of stock of one of the
other  corporations in such chain. When referring to a parent  corporation,  the
term "Related  Corporation"  shall mean any corporation (other than the Company)
in an unbroken chain of corporations  ending with the Company if, at the time of
granting of the Option,  each of the  corporations  other than the Company  owns
stock  possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock of one of the other corporations in such chain.

3.       STOCK

         Options to  purchase an  aggregate  of 350,000  shares of Common  Stock
(subject to adjustment  as provided in Section  4.12) may be issued  pursuant to
the Plan.  As of the date that a person is  initially  elected or appointed as a
Director,  the  Company  shall  automatically  grant to such  person  options to
purchase 25,000 shares of the Company's authorized but unissued,  or reacquired,
Common Stock (subject to adjustment as provided in Section  4.12).  In addition,
for each  Director  who is in office the day  following  any  annual  meeting of
shareholders  of the Company (at which meeting such  Director was  re-elected or
continued  in office) and who has been in office for at least five months  prior
to such annual meeting, the Company will automatically grant options to purchase
10,000  shares of Common  Stock  (subject to  adjustment  as provided in Section
4.12). In the event that any outstanding Option expires or is terminated for any
reason,  those shares of Common Stock  allocable to the  unexercised  portion of
such Option may be subject to one or more other Options  issued  pursuant to the
Plan.


<PAGE>

4.       TERMS AND CONDITIONS OF OPTIONS

         Each Option shall be evidenced by a written agreement (the "Agreement")
in the form  approved by the Company.  Agreements  may contain  such  additional
provisions, not inconsistent herewith, as the Company in its discretion may deem
advisable. All Options shall also comply with the following requirements:

         4.1      NUMBER OF SHARES

         Each Agreement shall state the number of shares to which it pertains.

         4.2      DATE OF GRANT

         Each Option shall state the date the Company and the  Director  entered
into the Agreement (the "Date of Grant"),  which shall be (i) in the case of new
Directors,  the date the individual  becomes a Director,  or (ii) in the case of
Directors in office the day after any annual meeting of  shareholders,  the date
after such meeting whichever is applicable.

         4.3      OPTION PRICE

         The exercise price for all Options granted  hereunder shall be the fair
market value on Date of Grant. Such fair market value shall be the closing price
at which it was traded on a national  securities exchange or the last sale price
quoted on the National  Association of Securities  Dealers  Automated  Quotation
System or any successor or  substantially  similar market thereto on the Date of
Grant.  If the Common  Stock shall be traded on more than one such  market,  the
exercise price shall be determined on the basis of the most active market. If no
such market exists, the exercise price shall be established at fair market value
based on the most recent arms-length  transaction occurring within eighteen (18)
months   preceding   the  Date  of  Grant  by  or  among  the   Company  or  any
greater-than-ten-percent  (>10%) shareholders of the Company or, if unavailable,
by a qualified appraiser selected by the Company.

         4.4      VESTING SCHEDULE

         All Options shall vest according to the following schedule:

                                            PERCENTAGE OF
         NUMBER OF YEARS                   TOTAL OPTION TO
     FOLLOWING DATE OF GRANT               BE EXERCISABLE
  ------------------------------        --------------------
                1                               33 1/3%
                2                               33 1/3%
                3                               33 1/3%


<PAGE>

         4.5      ACCELERATION OF VESTING

         Options granted  pursuant to the Plan shall become  immediately  vested
and fully  exercisable  upon the  Director's  termination  as a director  of the
Company by reason of the death or  Disability  (as defined in Section 4.6 below)
of the  Director.  The vesting of Options  shall also be  accelerated  under the
circumstances described in Sections 4.12 and 4.13 below.

         4.6      TERMINATION OF OPTION

         A  vested  Option  shall  terminate,   to  the  extent  not  previously
exercised, upon the occurrence of the first of the following events:

                   (i)     ten (10) years from the Date of Grant;

                  (ii) the  expiration  of  ninety  (90)  days  from the date of
Optionee's  termination  as a Director of the Company for any reason  other than
death or Disability (as defined below); or

                 (iii) the  expiration of one (1) year from the date of death of
Optionee  or the  cessation  of  Optionee's  service as a Director  by reason of
Disability (as defined below).

         "Disability"  shall  mean  that a person  is  unable  to  engage in any
substantial gainful activity by reason of any medically determinable physical or
mental  impairment that can be expected to result in death or that has lasted or
can be  expected  to last for a  continuous  period of not less than twelve (12)
months.  If Optionee's  service as a Director is terminated by death, any Option
held by Optionee shall be exercisable only by the person or persons to whom such
Optionee's rights under such Option shall pass by Optionee's will or by the laws
of descent and  distribution  of the state or country of Optionee's  domicile at
the time of death.  Each unvested Option granted pursuant hereto shall terminate
upon Optionee's  termination as a Director for any reason whatsoever,  including
death or Disability.

         4.7      EXERCISE OF OPTIONS

         Options shall be exercisable,  either all or in part, at any time after
vesting.  If less than all of the shares  included in the vested  portion of any
Option are  purchased,  the  remainder may be purchased at any  subsequent  time
prior to the  expiration  of the Option  term.  No portion of any Option of less
than one (1)  share  (as  adjusted  pursuant  to  Section  4.12  hereof)  may be
exercised; PROVIDED, that if the vested portion of any Option is less than fifty
(50)  shares,  it may be  exercised  with  respect to all shares for which it is
vested. Only whole shares may be issued pursuant to an Option, and to the extent
that an Option  covers  less than one  share,  it is  unexercisable.  Options or
portions thereof may be exercised by giving to the Company an executed notice of
election to  exercise,  which  notice  shall  specify the number of shares to be
purchased,  and be accompanied by payment in the amount of the aggregate  option
price for the Common Stock so purchased and in the form specified in Section 4.8
below.  The  Company  shall not be  obligated  to issue,  transfer  or deliver a
certificate of Common Stock to any Director, or to his personal  representative,
until the  aggregate  option  price has been paid for all  shares  for which the
Option shall have been  exercised  and adequate  provision  has been made by the
Optionee for the satisfaction of any tax withholding obligations associated with
such exercise. During the lifetime of an Optionee,  Options are exercisable only
by Optionee.


<PAGE>

         4.8      PAYMENT UPON EXERCISE OF OPTION

         Upon exercise of any option,  the aggregate  option price shall be paid
to the Company in cash or by  certified  or cashier's  check.  Alternatively,  a
Director may pay for all or any portion of the aggregate  option  exercise price
(i) by delivering to the Company shares of Common Stock  previously held by such
Director,  (ii) having shares withheld from the amount of shares of Common Stock
to be received by the Director or (iii)  delivering an irrevocable  subscription
agreement obligating the Director to take and pay for the shares of Common Stock
to be  purchased  within  one (1) year of the date of  exercise.  The  shares of
Common Stock received or withheld by the Company as payment for shares of Common
Stock  purchased  upon the exercise of Options shall have a fair market value at
the date of exercise (as determined in accordance  with Section 4.3 above) equal
to the aggregate  option  exercise price (or portion  thereof) to be paid by the
Director upon exercise.

         4.9      RIGHTS AS A SHAREHOLDER

         An Optionee  shall have no rights as a shareholder  with respect to any
shares covered by the Option until such Optionee becomes a record holder of such
shares,  irrespective  of whether  such  Optionee  has given notice of exercise.
Subject to the  provisions  of  Sections  4.12 and 4.13 below,  no rights  shall
accrue to an Optionee and no  adjustments  shall be made on account of dividends
(ordinary or  extraordinary,  whether in cash,  securities or other property) or
distributions  or other rights  declared on, or created in, the Common Stock for
which the record date is prior to the date the Optionee  becomes a record holder
of the shares of Common  Stock  covered by the Option,  irrespective  of whether
such Optionee has given notice of exercise.

         4.10     TRANSFER OF OPTION

         Options granted under this Plan and the rights and privileges conferred
by this Plan may not be  transferred,  assigned,  pledged or hypothecated in any
manner  (whether  by  operation  of law or  otherwise)  other than by will or by
applicable  laws of descent  and  distribution,  as defined by the Code,  or the
Employee   Retirement   Income  Security  Act,  or  the  rules  and  regulations
thereunder,  and  shall not be  subject  to  execution,  attachment  or  similar
process. Upon any attempt to transfer,  assign, pledge, hypothecate or otherwise
dispose  of any  Option  or of any  right or  privilege  conferred  by this Plan
contrary to the provisions  hereof,  or upon the sale, levy or any attachment or
similar  process upon the rights and  privileges  conferred  by this Plan,  such
Option shall thereupon terminate and become null and void.

         4.11     SECURITIES REGULATION AND TAX WITHHOLDING

                  4.11.1  Shares  shall not be issued with  respect to an Option
unless the  exercise of such Option and the issuance and delivery of such shares
shall comply with all relevant provisions of law, including, without limitation,
any applicable  state  securities  laws, the Securities Act of 1933, as amended,
the  Securities  Exchange  Act of 1934,  as amended,  the rules and  regulations
thereunder and the requirements of any stock exchange upon which such shares may
then be listed,  and such issuance  shall be further  subject to the approval of
counsel  for  the  Company  with  respect  to  such  compliance,  including  the
availability of an exemption from registration for the issuance and sale of such
shares.  The  inability  of the Company to obtain from any  regulatory  body the
authority deemed by the Company to be necessary for the lawful issuance and sale
of any shares  under this  Plan,  or the  unavailability  of an  exemption  from
registration  for the  issuance  and sale of any shares  under this Plan,  shall
relieve the Company of any liability with respect to the non-issuance or sale of
such shares.


<PAGE>

         As a condition  to the  exercise of an Option,  the Company may require
the  Optionee to represent  and warrant in writing at the time of such  exercise
that the  shares  are  being  purchased  only for  investment  and  without  any
then-present  intention to sell or distribute such shares.  At the option of the
Company,  a  stop-transfer  order against such shares may be placed on the stock
books and records of the Company, and a legend indicating that the stock may not
be  pledged,  sold or  otherwise  transferred  unless an  opinion  of counsel is
provided stating that such transfer is not in violation of any applicable law or
regulation, may be stamped on the certificates representing such shares in order
to assure an  exemption  from  registration.  The Company  also may require such
other documentation as may from time to time be necessary to comply with federal
and  state   securities  laws.  THE  COMPANY  HAS  NO  OBLIGATION  TO  UNDERTAKE
REGISTRATION  OF OPTIONS OR THE SHARES OF STOCK  ISSUABLE  UPON THE  EXERCISE OF
OPTIONS.

                  4.11.2 As a condition  to the  exercise of any Option  granted
under this Plan,  the Optionee shall make such  arrangements  as the Company may
require for the  satisfaction  of any federal,  state or local  withholding  tax
obligations that may arise in connection with such exercise.

                  4.11.3 The issuance,  transfer or delivery of  certificates of
Common  Stock  pursuant  to the  exercise  of  Options  may be  delayed,  at the
discretion  of the Board,  until the Company is  satisfied  that the  applicable
requirements  of the  federal  and  state  securities  laws and the  withholding
provisions of the Code have been met.

         4.12     STOCK DIVIDEND, REORGANIZATION OR LIQUIDATION

                  4.12.1 If (i) the  Company  shall at any time be involved in a
transaction described in Section 424(a) of the Code (or any successor provision)
or any "corporate transaction" described in the regulations thereunder; (ii) the
Company shall declare a dividend payable in, or shall subdivide or combine,  its
Common Stock or (iii) any other event with  substantially  the same effect shall
occur,  the number of shares of Common Stock and/or the exercise price per share
of each outstanding Option shall be  proportionately  adjusted so as to preserve
the  rights of the  Optionee  substantially  proportionate  to the rights of the
Optionee  prior to such event,  and to the extent that such action shall include
an  increase  or  decrease  in the number of shares of Common  Stock  subject to
outstanding Options, the number of shares available under Section 4 of this Plan
shall   automatically   be  increased  or   decreased,   as  the  case  may  be,
proportionately,  without  further  action  on the  part of the  Company  or the
Company's shareholders.

                  4.12.2 If the Company is liquidated or dissolved,  the holders
of any outstanding  Options may exercise all or any part of the unvested portion
of the Options held by them; PROVIDED, that such Options must be exercised prior
to the effective date of such liquidation or dissolution.  If the Option holders
do not exercise their Options prior to such  effective  date,  each  outstanding
Option  shall  terminate  as  of  the  effective  date  of  the  liquidation  or
dissolution.

                  4.12.3 The grant of an Option  shall not affect in any way the
right  or  power  of  the  Company  to  make   adjustments,   reclassifications,
reorganizations  or changes  of its  capital or  business  structure,  to merge,
consolidate or dissolve,  to liquidate or to sell or transfer all or any part of
its business or assets.


<PAGE>

         4.13     CHANGE IN CONTROL; DECLARATION OF EXTRAORDINARY DIVIDEND

                  4.13.1   CHANGE IN CONTROL

         If at any time there is a Change in Control (as  defined  below) of the
Company,  all Options shall  accelerate and become fully vested and  immediately
exercisable for the duration of the Option term. For purposes of this Subsection
4.13.1, "Change in Control" shall mean either one of the following: (i) When any
"person,"  as such term is used in sections  13(d) and 14(d) of the Exchange Act
(other than a shareholder  of the Company on the date of this Plan, the Company,
a Subsidiary or an employee  benefit plan of the Company,  including any trustee
of such plan  acting as  trustee)  becomes,  after  the date of this  Plan,  the
"beneficial  owner" (as defined in Rule 13d-3 under the Exchange Act),  directly
or indirectly,  of securities of the Company representing fifty percent (50%) or
more of the combined voting power of the Company's then outstanding  securities;
or (ii) the  occurrence of a transaction  requiring  shareholder  approval,  and
involving the sale of all or  substantially  all of the assets of the Company or
the merger of the Company with or into another corporation.

                  4.13.2   DECLARATION OF EXTRAORDINARY DIVIDEND

         If at any time the  Company  declares  an  Extraordinary  Dividend  (as
defined below),  all Options shall  accelerate and thereupon become fully vested
and immediately exercisable for the duration of the Option term. For purposes of
this  Subsection  4.13.2,  "Extraordinary  Dividend"  shall mean a cash dividend
payable to  holders of record of the Common  Stock in an amount in excess of ten
percent (10%) of the then fair market value of the Company's  Common Stock.  The
fair market  value of the  Company's  Common Stock shall be  determined  in good
faith by the Board.

5.       EFFECTIVE DATE; TERM

         Subject to approval of this Plan by shareholders  of the Company,  this
Plan  shall  be  effective  as of the  date  which  is the  first  Date of Grant
specified in Section 4.2 above,  and Options may be issued then and from time to
time  thereafter  until this Plan is terminated by the Company.  Termination  of
this Plan shall not terminate any Option granted prior to such termination.

6.       NO OBLIGATIONS TO EXERCISE OPTION

         The granting of an Option shall impose no obligation  upon the Optionee
to exercise such Option.

7.       APPLICATION OF FUNDS

         The  proceeds  received by the Company  from the sale of Common  Stock,
pursuant to the exercise of Options granted hereunder,  will be used for general
corporate purposes.


<PAGE>

8.       INDEMNIFICATION OF BOARD

         In addition  to all other  rights or  indemnification  they may have as
directors of the Company or as members of the Board,  members of the Board shall
be indemnified by the Company for all reasonable expenses and liabilities of any
type and nature,  including  reasonable  attorneys fees,  incurred in connection
with any action,  suit or proceeding to which they or any of them are a party by
reason of, or in connection with, the Plan or any Option granted hereunder,  and
against all amounts paid by them in settlement thereof (provided such settlement
is approved by independent legal counsel selected by the Company), except to the
extent that such  expenses  relate to matters for which it is adjudged that such
Board members are liable for willful misconduct;  PROVIDED,  that within fifteen
(15)  days  after  the  institution  of any  such  action,  suit or  proceeding,
member(s)  of the Board  shall,  in writing,  notify the Company of such action,
suit or  proceeding,  so that  the  Company  may have  the  opportunity  to make
appropriate arrangements to prosecute or defend the same.

9.       AMENDMENT OF PLAN

         The Company may, at any time, modify,  amend or terminate this Plan and
Options  granted  under  this  Plan,   including,   without   limitation,   such
modifications  or  amendments  as are  necessary  to  maintain  compliance  with
applicable  statutes,  rules or  regulations;  PROVIDED,  that no amendment with
respect  to an  outstanding  Option  shall  be made  over the  objection  of the
Optionee thereof and PROVIDED FURTHER,  that: (i) the approval of the holders of
a  majority  of  the  Company's  outstanding  shares  of  voting  capital  stock
represented at a meeting at which a quorum is present is required  within twelve
(12) months before or after the adoption by the Board of any amendment that will
permit the granting of Options to a class of persons other than those  currently
eligible to receive  Options under this Plan or that would cause this Plan to no
longer comply with Securities and Exchange Commission Rule 16b-3, as amended, or
any successor rule or other regulatory requirements and (ii) this Plan shall not
be amended  more than once  every six (6)  months,  other  than to comport  with
changes  in the  Code,  the  Employee  Retirement  Security  Act,  or the  rules
thereunder.

         Approved by the Company's Board of Directors,  as Amended and Restated,
as of April 10, 1997.

         Approved by the Company's  shareholders,  as Amended and  Restated,  on
June 2, 1997.





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