HANCOCK JOHN INSTITUTIONAL SERIES TRUST
497J, 1995-10-06
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JOHN HANCOCK [LETTERHEAD]


October 6, 1995 

U.S. Securities and Exchange Commission 
Judiciary Plaza 
450 Fifth Street, N.W. 
Washington, D.C.  20549 

Re:      John Hancock Institutional Series Trust 
           File Nos. 811-8852; 33-86102 

         CERTIFICATE UNDER RULE 497(j) 

Gentlemen: 

Pursuant to 497(j) of Regulation C, under the Securities Act of 1933, in lieu of
filing under paragraph (b) or (c) of Rule 497, I hereby certify that the form of
Red Herring Prospectus and Statement of Additional Information dated December,
1995 for the above-captioned registrants that would have been filed under
paragraph (b) or (c) of Rule 497(j) does not differ from that contained in the
most recent registration statement amendment and the text of most recent
registration statement has been filed electronically.

Sincerely, 

/s/Marilyn Lutzer 
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Marilyn Lutzer 


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