HANCOCK JOHN INSTITUTIONAL SERIES TRUST
N-30B-2, 1996-05-08
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<PAGE>
================================================================================
                               John Hancock Funds
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

                                  Institutional
                                  Series Trust

                  INDEPENDENCE BALANCED FUND
                  INDEPENDENCE GROWTH FUND
                  INDEPENDENCE MEDIUM CAPITALIZATION FUND
                  INDEPENDENCE VALUE FUND
                  INDEPENDENCE DIVERSIFIED CORE EQUITY FUND II

                                 ANNUAL REPORT

                               February 29, 1996



<PAGE>

<TABLE>
                                    Table Of Contents

                     John Hancock Funds - Institutional Series Trust

<CAPTION>
                                                                                     Page

<S>                                                                                   <C>
1) Chairman's Message...........................................................       3

2) Portfolio Manager Commentary
     These commentaries reflect the views of the portfolio manager or portfolio
     management team through the end of the Fund's period discussed in this 
     report. Of course, the manager's or team's views are subject to change as
     market and other conditions warrant.

     John Hancock Independence Balanced Fund....................................       4

     John Hancock Independence Growth Fund......................................       8

     John Hancock Independence Medium Capitalization Fund.......................      12

     John Hancock Independence Value Fund.......................................      16

     John Hancock Independence Diversified Core Equity Fund II..................      20

3) Financial Statements.........................................................      24

4) Notes To Financial Statements................................................      51
</TABLE>

<TABLE>
<S>                                  <C>                                        <C>
                                                                                                                     
              TRUSTEES                            Thomas H. Drohan                         INVESTMENT ADVISER                      
      Edward J. Boudreau, Jr.           Senior Vice President and Secretary           John Hancock Advisers, Inc.                
        Thomas W.L. Cameron                       James B. Little                         101 Huntington Avenue                  
          James F. Carlin*                   Senior Vice President and                   Boston, MA 02199-7603                   
       William H. Cunningham*                 Chief Financial Officer                                                            
         Charles F. Fretz*                        Susan S. Newton                        INVESTMENT SUB-ADVISER                  
       Harold R. Hiser, Jr.*                      Vice President,               Independence Investment Associates, Inc.          
         Charles L. Ladner*                   Assistant Secretary and                       53 State Street             
        Leo E. Linbeck, Jr.*                     Compliance Officer                         Boston, MA 02109            
       Patricia P. McCarter*                    James J. Stokowski,                                                     
       Steven R. Pruchansky*                Vice President and Treasurer                 PRINCIPAL DISTRIBUTOR              
        Richard S. Scipione                                                             John Hancock Funds, Inc.        
          John P. Toolan*                             CUSTODIAN                          101 Huntington Avenue               
    * Members of Audit Committee              Investors Bank & Trust Company             Boston, MA 02199-7603                  
                                                    89 South Street                                                     
              OFFICERS                              Boston, MA 02110                          LEGAL COUNSEL             
      Edward J. Boudreau, Jr.,                                                                Hale and Dorr             
Chairman and Chief Executive Officer                TRANSFER AGENT                           60 State Street            
         Robert G. Freedman           John Hancock Investor Services Corporation             Boston, MA 02109                  
         Vice Chairman and                         P.O. Box 9277                                                                  
      Chief Investment Officer                 Boston, MA 02205-9277                    INDEPENDENT ACCOUNTANTS         
          Anne C. Hodsdon                                                                 Arthur Andersen LLP              
             President                                                                  One International Place         
                                                                                         Boston, MA 02110-2604
</TABLE>
                                                                                
                                       2

<PAGE>
                               CHAIRMAN'S MESSAGE

DEAR FELLOW SHAREHOLDERS: 

The stock market's record-breaking, whirlwind performance in 1995 will be a
tough act to follow in 1996. In fact, we've already seen greater market
volatility this year, particularly among last year's leaders N technology
stocks. That's to be expected after a year that saw market indexes soar,
including the Standard & Poor's 500-Stock Index's 37% advance. While many of the
same economic conditions that fostered the stellar 1995 market are still in
place N slow economic growth, muted inflation and decent corporate earnings N it
would be unrealistic to expect the market to stage a repeat in 1996. The old
saying "trees don't grow to the sky" comes to mind. Shareholders would do well
to temper expectations of investment returns and perhaps revisit their
investment allocations to determine if rebalancing their portfolio makes sense.

[PHOTO: A 1 1/4" x 1" photo of Edward J. Boudreau, Jr., Chairman and Chief 
Executive Officer, flush right, next to second paragraph.]

     No matter how you scale back your market expectations, you should always be
able to count on consistent customer service performance. At John Hancock Funds,
we never stop working to find ways to sustain and improve the quality of
information and assistance we provide you. Our commitment to this task is no
less than John Hancock's loyalty was to his fledgling country when he is said to
have uttered, "if it does the public good, burn Boston." We won't go that far,
of course, but we share our namesake's dedication to putting the public before
all else.

     In our case, that public is you, our shareholders. We take very seriously
the role you have entrusted to us, that of helping you achieve your financial
goals. Part of that will always involve good customer service. So please do not
hesitate to call a Customer Service Representative at 1-800-755-4371 if you have
any questions or need information. We take pride in helping you with the same
spirit that John Hancock displayed at the dawning of America.

Sincerely,

/s/ Edward J. Boudreau, Jr.

    EDWARD J. BOUDREAU, JR., CHAIRMAN AND CHIEF EXECUTIVE OFFICER

                                       3



<PAGE>

                     BY JANE A. SHIGLEY AND JEFFREY B. SAEF
                        FOR THE PORTFOLIO MANAGEMENT TEAM

                                  John Hancock
                           Independence Balanced Fund

                    Fund continues to build positions during
                    ----------------------------------------
                           strong stock, bond markets
                           --------------------------

[call out--left side]
"...Financial services companies...were strong performers for the Fund..."

Throughout the past eight months, the U.S. stock market continued to astound
many observers as most of the broad market measures broke through to record
heights. The stock market's gains stemmed largely from lower interest rates and
rising company profits and earnings. The U.S. bond market also showed surprising
strength during five of the past six months, fueled as well by falling interest
rates, a benign inflation outlook and expectations of a slow growth economy. In
January, the Federal Reserve Board cut short-term interest rates one-quarter
point, but investors were disappointed with the magnitude of that action. In the
following weeks, they also worried that scattered signs of economic strength
could be enough to stall any further Fed cuts. These factors set the stage for
the bond market's slight pullback in February. 

     From July 6, 1995, through February 29, 1996, John Hancock Independence
Balanced Fund posted a total return of 10.42% at net asset value, while the
average balanced fund returned 10.95%, according to Lipper Analytical Services.
During the same period, a 50/50 blended index combining the Standard & Poor's
500-Stock Index and the Lehman Brothers Government/Corporate Bond Index (L.G.C.)
returned 12.09%, as tracked by the Frank Russell Company.

     The Fund has the flexibility to weigh either stocks or bonds to as high as
75% of its investments as market and economic conditions warrant. However, we
continued to keep the

[PHOTO: A 2 1/2" x 3 1/2" photo of Jane A. Shigley and Jeffrey B. Saef at 
bottom right. Caption reads: "Jane A. Shigley and Jeffrey B. Saef."]

                                       4

<PAGE>
   John Hancock Funds - Institutional Series Trust -- Independence Balanced Fund

[call out--right side]
"...our stock market outlook calls for continued corporate earnings growth, but
not as strong as 1995." 

[CHART: Bar chart with the heading "Fund Performance" at top left hand column. A
footnote below states "For the period July 6, 1995 through February 29, 1996."
The chart is scaled in increments of 5% from bottom to top, with 15% at the top
and 0% at the bottom. Within the chart are three solid bars. The first
represents 10.42% total return for John Hancock Independence Balanced Fund. The
second represents 10.95% total return for the average balanced fund. The third
represents 12.09% total return for the 50% S&P 500-Stock Index/50% L.G.C. Bond
Index. A footnote below reads: "The total return for John Hancock Independence
Balanced Fund is at net asset value with all dividends reinvested. The average
capital appreciation fund is tracked by Lipper Analytical Services. The S&P
500-Stock Index and the Lehman Brothers Government/Corporate Bond Index are
unmanaged indices commonly used as broad measures of stock and bond performance.
The performance is tracked by Frank Russell Company. See following page for
historical information.]

Fund almost evenly divided between stocks and bonds during the period.

Financials, Health-care Stocks Winners

On the equity side, we continued to apply our disciplined investment style.
Using a team of research analysts, we combine human analysis and computer
valuation models to rank our investment universe. The most attractively ranked
stocks are generally "cheap" stocks with improving fundamentals. Additionally,
we kept an eye toward diversifying across a broad range of stocks -- such as
growth and value, large and small companies -- in order to spread and reduce the
overall volatility of the Fund.

     Financial services companies, such as American Express, benefited from a
favorable interest-rate environment and were strong performers for the Fund
during its first fiscal year. Health-care companies -- including Johnson &
Johnson and Bristol-Myers Squibb -- also provided good gains on the heels of new
product developments and rising earnings. Finally, PepsiCo, one of the fund's
largest holdings and best performers during the period, was buoyed by its
growing snack food and soft drink businesses.

Fixed Income Strategy

Because the Fund is still in its early stages, we believe that the best way to
provide a diversified and liquid portfolio was to put our fixed-income money to
work in the U.S. Treasury market. As the Fund grows, we will move toward
generally dividing its bond holdings roughly as follows: 50% in government
securities, 35% in corporate bonds and 15% in mortgage-backed securities. When
opportunities within these sectors present themselves, however, there may be
times when we will tilt these weightings slightly away from the norm.

Outlook

As we begin 1996, our stock market outlook calls for continued corporate
earnings growth, but not as strong as 1995. If the economy chugs along at a
moderate growth rate, and interest rates continue to stay low, we could see more
upside from stocks. As far as the bond market goes, we believe that the pullback
the market experienced in February allows for a more constructive environment
going forward. But regardless of market conditions, we'll stick to our
disciplined investment style in striving for above-average total returns.


                                       5

<PAGE>

                              A LOOK AT PERFORMANCE
                                                                            
<TABLE>

The table on the right shows the cumulative total return for the John Hancock
Independence Balanced Fund. Total return is a performance measure that equals
the sum of all income and capital gains dividends, assuming reinvestment of
these distributions, and the change in the price of the Fund's shares, expressed
as a percentage of the Fund's net asset value per share. Remember that all
figures represent past performance and are no guarantee of how the Fund will
perform in the future. Also, keep in mind that the total return and share price
of the Fund's investments will fluctuate. As a result, your Fund's shares may be
worth more or less than their original cost, depending on when you sell them.

                             CUMULATIVE TOTAL RETURN


For The Period Ended December 31, 1995             
<CAPTION>

                                            LIFE OF
                                              FUND 
                                              ----
<S>                                           <C>
John Hancock Independence Balanced Fund (1)   9.23%


                              Notes On Performance
(1)  Commenced on July 6, 1995

</TABLE>

                                     

                                       6

<PAGE>

                    WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Independence Balanced Fund would be worth on February 29, 1996, assuming you
invested on the day the Fund started and have reinvested all distributions. For
comparison, we've shown the same $250,000 investment in a blend of 50% in the
Standard & Poor's 500 Stock Index and 50% in the Lehman Brothers Government/
Corporate Bond Index. The Standard & Poor's 500 Stock Index is an unmanaged
index that includes 500 widely traded common stocks and is a commonly used mea
sure of stock market performance. The Lehman Brothers Government/Corporate Bond
Index is an unmanaged index that measures the performance of U.S. government
bonds, U.S. corporate bonds, and Yankee bonds.

[CHART: Line chart with the heading Independence Balanced Fund, representing the
growth of a hypothetical $250,000 investment over the life of the fund. Within
the chart are two lines.

The first line represents the value of the Standard & Poor's 500 Stock Index and
is equal to $280,249 as of February 29, 1996. The second line represents the
value of the hypothetical $250,000 investment made in the Independence Balanced
Fund on July 6, 1995 and is equal to $276,055 as of February 29, 1996.]

                                       7



<PAGE>

              BY COREEN KRAYSLER FOR THE PORTFOLIO MANAGEMENT TEAM

                                  John Hancock
                            Independence Growth Fund

                     Stocks move higher led by technology,
                     -------------------------------------
                        finance and health-care sectors
                        -------------------------------

[call out--left side]
"...U.S. stock indexes posted some of their highest annual returns ever in
1995."

To the surprise of many, the stock market has just kept on climbing. Propelled
by low inflation, moderate economic growth and huge investor inflows, U.S. stock
indexes posted some of their highest annual returns ever in 1995. Among the
winners were large company stocks, and technology, finance and health-care
shares. The upward momentum continued into early 1996. For the year ended
February 29, 1996, the Russell 1000 Growth Index advanced 35.67%.

     Into this favorable climate, we launched John Hancock Independence Growth
Fund. The Fund had a total return of 9.94% at net asset value from its opening
on October 2, 1995 through February 29, 1996. This number isn't particularly
meaningful, however, because it's based on such a short time early in the Fund's
life. During the same period, the Russell 1000 Growth Index N the Fund's
benchmark N returned 10.03% and the average growth and income fund returned
8.86%, according to Lipper Analytical Services.

Strategy and performance

We believe our strategy made the difference in our results. Our goal is to
deliver above-average total return by focusing on stocks that are cheap with
improving fundamentals. In other words, we look for stocks anywhere we can find
them that are priced at less than what they're worth and show signs of improving
prospects. To find securities like this, we conduct in-depth research on
companies, looking at measures like earnings growth, sales projections, cash
flow and dividends. From that, we come up with earnings and growth estimates.
Then our proprietary models digest this data to generate a ranking of stocks
from most to least attractive, based on both cheapness and improving
fundamentals. We use this list in tailoring the Fund to mirror the risk
characteristics

[PHOTO: A 2 1/4" x 2 1/4" photo of Coreen Kraysler centered at bottom of page.
Caption reads: "Coreen Kraysler."]

                                       8

<PAGE>

   John Hancock Funds - Institutional Series Trust -- Independence Growth Fund

[call out--right side]
"...we'll stick to looking for cheap stocks with improving fundamentals." 

[CHART: Bar chart with the header "Fund Performance" at top left hand column. A
footnote below states: "For the period October 2, 1995 through February 29,
1996." The chart is scaled in increments of 5%, with 15% at top and 0% at
bottom. Within the chart there are three solid bars. The first represents the
9.94% total return for John Hancock Independence Growth Fund. The second
represents the 8.86% total return for the average growth and income fund. The
third represents the 10.03% total return for the Russell 1000 Growth Index. A
footnote below states: "The total return for John Hancock Independence Growth
Fund is at net asset value with all distributions reinvested. the average growth
and income fund is tracked by Lipper Analytical Services. The Russell 1000
Growth Index is an unmanaged index comprised of stocks with greater than average
growth orientation. It is comprised of securities of the largest 1000 public
companies in the United States equity markets. See following page for historical
performance information."]

and industry weightings of the Russell 1000 Growth Index.

     During its first five months, the Fund benefited most from our stock
selection in the drug, technology and chemical sectors. In the drug group --
about 11% of the Fund's total net assets N one of the top contributors to
performance was Johnson & Johnson. Its stock price rose 30% during the period
largely because of its strong array of new products. About 13% of the Fund's
investments were in technology, where one of the top performers was Digital
Equipment Corporation. Strong earnings sent the company's stock up 15% in the
first two months of 1996. In the chemical group, Monsanto returned 30% for the
five-month period, thanks to its success in developing products that rely on
biotechnology to help lower farming costs.

     In addition, some of our largest investments gave the Fund a strong start.
Three of them -- PepsiCo, Philip Morris, and General Electric (GE) -- benefited
from strong international growth. At PepsiCo, improved earnings from the
company's restaurant operations, worldwide dominance in the snack food business
and a share buy back program also gave the stock a boost. Philip Morris' huge
cash flow (that is, earnings after capital expenditures) helped its stock
performance, as did GE's strong portfolio of businesses.

     Of course, there were also disappointments. Among them was Home Depot,
which suffered from the slowdown in housing turnover and steep decline in lumber
prices. The combination was simply too much to overcome. Nevertheless, we held
onto the stock, believing that it's well-positioned to benefit once home sales
do pick-up.

     Our outlook is for more of the same: continued low inflation with moderate
economic growth. Under this scenario, we could see decent stock market returns
in 1996. But it's unlikely they'd rival 1995's exceptional results. Regardless
of what happens, we'll stick to looking for cheap stocks with improving
fundamentals. We believe this strategy works in all market climates and can help
the Fund produce strong long-term results.


                                       9

<PAGE>

                             A LOOK AT PERFORMANCE


<TABLE>
The table on the right shows the cumulative total return for the John Hancock
Independence Growth Fund. Total return is a performance measure that equals the
sum of all income and capital gains dividends, assuming reinvestment of these
distributions, and the change in the price of the Fund's shares, expressed as a
percentage of the Fund's net asset value per share. Remember that all figures
represent past performance and are no guarantee of how the Fund will perform in
the future. Also, keep in mind that the total return and share price of the
Fund's investments will fluctuate. As a result, your Fund's shares may be worth
more or less than their original cost, depending on when you sell them.

<CAPTION>
                            CUMULATIVE TOTAL RETURN

For the period ended December 31, 1995

                                                   LIFE OF
                                                    FUND
                                                    ----

<S>                                                 <C>   
John Hancock Independence Growth Fund(1)            4.85% 




                              Notes To Performance

(1)  Commenced on October 2, 1995.
</TABLE>



                                       10

<PAGE>

                    WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Independence Growth Fund would be worth on February 29, 1996, assuming you
invested on the day the Fund started and have reinvested all distributions. For
comparison, we've shown the same $250,000 investment in the Russell 1000 Growth
Index -- an unmanaged capitalization-weighted price-only index, which is
comprised of 1,000 of the largest capitalized U.S. domiciled companies whose
common stock traded in the United States on the New York Stock Exchange. The
securities in this index have less than average growth orientation.

[CHART: Line chart with the heading Independence Growth Fund, representing the
growth of hypothetical $250,000 investment over the life of the fund. Within the
chart are two lines.

The first line represents the value of the Russell 1000 Growth Index and is
equal to $276,975 as of February 29, 1996. The second line represents the value
of the hypothetical $250,000 investment made in the Independence Growth Fund on
October 2, 1995 and is equal to $274,852 as of February 29, 1996.]

                                       11

<PAGE>

               BY DAVID CANAVAN FOR THE PORTFOLIO MANAGEMENT TEAM

                                  John Hancock
                              Independence Medium
                              Capitalization Fund

                Fund launched in strong stock market environment
                ------------------------------------------------

[CALL OUT -- LEFT SIDE]
"One of the major themes for the stock market's prospects in 1996 will be the
economic climate."

Over the past five months the stock market has grabbed headlines as it continued
to reach record highs, then outdo itself by eventually breaking through these
records. Company earnings were strong, interest rates were falling and while
economic growth was slow, it was steady. However, the rally didn't treat all
stocks equally. Large capitalization stocks -- represented by the Standard &
Poor's 500-Stock Index -- were the market leaders, up over 10% during that
period. Their strong performance can be attributed, in part, to the fact that
individual investors poured records amounts of cash into the stock market
through mutual funds. The managers of those funds, in turn, gravitated toward
the more liquid, larger-cap stocks. Small capitalization stocks, as measured by
the Russell 2000, were up only 5.25%. Medium capitalization stocks, meanwhile,
fell nicely between the two, and the Callan Medium Capitalization Index returned
8.05% for the period.

Strategy/performance review

From its inception on October 2, 1995 through February 29, 1996, John Hancock
Independence Medium Capitalization Fund had a total return of 9.71% at net asset
value. The result isn't particularly meaningful, however, because it is based on
such a short term early in the life of the Fund. For the same period, the
average mid cap fund returned 6.08%, accord ing to Lipper Analytical Services.

     At the core of our investment philosophy is the conviction that the most
attractive stocks -- those with the best chances of outperforming the Callan
Medium Capitalization index -- combine cheapness with improving fundamentals. By
cheapness, we mean that the current price of

[PHOTO: A 2 1/2" x 2" photo of David Canavan centered at bottom. Caption reads
"David Canavan."]

                                       12

<PAGE>

                John Hancock Funds - Institutional Series Trust --
                    Independence Medium Capitalization Fund

[CALL OUT -- RIGHT SIDE]
"Many of our oil stocks...did particularly well during the period."

[CHART: Bar chart with the header "Fund Performance" at top left hand column. A
footnote below states: "For the period October 2, 1995 through February 29,
1996." The chart is scaled in increments of 5%, with 10% at top and 0% at
bottom. Within the chart there are three solid bars. The first represents the
9.71% total return for John Hancock Independence Medium Capitalization Fund. The
second represents the 6.08% total return for the average mid-cap fund. The third
represents the 8.05% total return for the Callan Medium Capitalization Index. A
footnote below states: "The total return for John Hancock Independence Medium
Capitalization Fund is at net asset value with all distributions reinvested. the
average medium capitalization fund is tracked by Lipper Analytical Services. The
Callan Medium Capitalization Index is an unmanaged index commonly used as a
broad measure of performance of the stock of companies with market
capitalization of $1 billion to $5 billion. See following page for historical
performance information.]


a given security is not reflecting what we believe to be its fair value. By
improving fundamentals, we're referring to the notion that a company's basic
business is getting better.

     Many of our oil stocks, including Anadarko, and Phillips Petroleum did
particularly well during the period. The harsh Northeast winter led to
higher-than-normal draws on a relatively low energy supply and helped push the
price of oil, and oil-related stocks, higher. Health-care stocks, particularly
those companies that apply some technology to their core businesses, also were
winners. Guidant Corp., for instance, is a leader in using technology in its
pulmonary devices. Airlines stocks rallied on a wave of good news. Greater
passenger traffic, and the labor agreement with Delta pilots not only lifted
Delta stock, but also Northwest Airlines and UAL Corp., the parent company of
United Airlines. Within the financial sector, insurance companies such as
Lincoln National and Allstate and banks such as Chemical Bank, got a boost from
falling interest rates.

     Many of our technology stocks, on the other hand, proved to be
disappointing. It's not altogether surprising that the sector experienced a
sharp pullback toward the end of the period, given its robust strength during
most of 1995. Semiconductor makers and manufacturers of semiconductor equipment
- -- including LSI Logic, National Semiconductor and LAM Research -- were among
the hardest hit. Because the underlying fundamentals of these semiconductor
companies had deteriorated significantly, we pared back our stake in them.

Outlook for 1996

One of the major themes for the stock market's prospects in 1996 will be the
economic climate. In our view, inflation will remain low at between 2.5% and 3%
this year. Meanwhile, we expect the economy to continue to grow, although the
pace could be weaker than in 1995. Our estimates call for real gross domestic
product growth to decline to 1% in 1996. However, that scenario still provides a
fairly healthy backdrop for the stock market. Given our economic outlook, we
expect corporate earnings to grow an average of 5% in 1996, down from 18% in
1995. So while it's unlikely that the market will achieve last year's tremendous
gains, stocks could perform more in line with historical returns. Regardless of
market conditions, we'll continue to focus on finding stocks within our universe
that offer the best potential for outperforming the medium capitalization sector
as a whole.



                                       13

<PAGE>


                             A LOOK AT PERFORMANCE

<TABLE>
The table on the right shows the cumulative total return for the John Hancock
Independence Medium Capitalization Fund. Total return is a performance measure
that equals the sum of all income and capital gains dividends, assuming
reinvestment of these distributions, and the change in the price of the Fund's
shares, expressed as a percentage of the Fund's net asset value per share.
Remember that all figures represent past performance and are no guarantee of how
the Fund will perform in the future. Also, keep in mind that the total return
and share price of the Fund's investments will fluctuate. As a result, your
Fund's shares may be worth more or less than their original cost, depending on
when you sell them.

                            CUMULATIVE TOTAL RETURN

<CAPTION>
For the period ended December 31, 1995

                                                                   LIFE OF
                                                                     FUND
                                                                     ----

<S>                                                                  <C>   
John Hancock Independence Medium Capitalization Fund(1)              4.75% 


                              Notes to Performance
(1) Commenced on October 2, 1995.
</TABLE>



                                       14

<PAGE>

                    WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Independence Medium Capitalization Fund would be worth on February 29, 1996,
assuming you invested on the day the Fund started and have reinvested all
distributions. For comparison, we've shown the same $250,000 investment in the
Callan Medium-Capitalization Index -- a subset of the Callan Broad Market Index.
The Callan Broad Market Index is an unmanaged index that includes common stocks
of the two thousand largest companies with capitalizations ranging between $85
million and $75 billion. This index includes both growth and value stocks.

[CHART: Line chart with the heading Independence Medium Capitalization Fund,
representing the growth of a hypothetical $250,000 investment over the life of
the fund. Within the chart are two lines.

The first line represents the value of the hypothetical $250,000 investment made
in the Independence Medium Capitalization Fund on October 2, 1995 and is equal
to $274,269 as of February 29, 1996. The second line represents the value of the
Callan Medium-Capitalization Index and is equal to $270,125 as of February 29,
1996.]

                                       15

<PAGE>

              BY COREEN KRAYSLER FOR THE PORTFOLIO MANAGEMENT TEAM

                      John Hancock Independence Value Fund

                      Fund starts with wind at its back as
                      ------------------------------------
                        stock market continues to climb
                        -------------------------------

[CALL OUT -- LEFT SIDE]
"Our strategy gave us an edge this period in the banking and insurance
sectors..."

John Hancock Independence Value Fund began on October 2, 1995, well into one of
the stock market's strongest years on record. With moderate economic growth, low
inflation, positive corporate earnings, and huge inflows from mutual funds, most
U.S. stock indexes returned over 30% for the year. Although high-flying
technology stocks pulled back late in 1995, many other sectors continued to
rise. The Russell 1000 Value Index, the Fund's benchmark, rose 34.14% for the
year ended February 29, 1996 -- and 10.79% during the last five months.

     This environment helped the Fund get off to a good start with a total
return of 12.52% at net asset value from October 2, 1995, through February 29,
1996. This number isn't particularly meaningful, however, because it's based on
such a short time early in the Fund's life. For the same period, the average
growth and income fund returned 8.86%, according to Lipper Analytical Services.

Strategy

We try to deliver an above-average total return by focusing on stocks that meet
two criteria. First, they have to be cheap, meaning that they're selling for
less than what we believe they're worth. And, second, they have to show signs of
improving fundamentals -- like a pick-up in earnings growth, sales projections,
cash flow or dividends. What we're aiming for are risk characteristics and
industry weightings that mirror the Russell 1000 Value Index, plus better stock
selection. To do this, our analysts research companies to come up with estimates
for earnings and growth potential. Then we feed this information into a
proprietary data base with models that rank the stocks from most to least
attractive. We use this list to tailor the Fund to look like the Index.

     Our strategy gave us an edge this period in the banking and insurance
sectors, which together represented 26% of the Fund's net assets.

[PHOTO: A 2 1/4" x 2 1/4" photo of Coreen Kraysler centered at bottom. Caption
reads: "Coreen Kraysler."]

                                       16

<PAGE>

           John Hancock Mutual Funds - Institutional Series Trust --
                            Independence Value Fund

[CALL OUT -- RIGHT SIDE]
"...we'll keep looking for cheap stocks with improving prospects."

[CHART: Bar chart with the header "Fund Performance" at top left hand column. A
footnote below states: "For the period October 2, 1995 through February 29,
1996." The chart is scaled in increments of 5%, with 10% at top and 0% at
bottom. Within the chart there are three solid bars. The first represents the
12.52% total return for John Hancock Independence Value Fund. The second
represents the 10.79% total return for the Russell 1000 Value Index. The third
represents the 8.86% total return for the average growth and income fund. A
footnote below states: "The total return for John Hancock Independence Value
Fund is at net asset value with all distributions reinvested. The average growth
and income fund is tracked by Lipper Analytical Services. The Russell 1000 Value
Index is comprised of stocks of companies from the Russell 1000 Index with a
less than average growth orientation. See following page for historical
performance information."]

Chemical Bank and First Chicago, two of our largest investments, benefited from
a favorable environment for financial stocks. In addition, Chemical Bank's stock
price rose on expectations that its merger with Chase Manhattan would cut costs
and strengthen earnings prospects. Meanwhile, First Chicago's stock rebounded
after investors decided concerns about its large credit card portfolio were
unfounded.

     Our energy selections -- about 11% of net assets -- also fueled the Fund's
return. In the oil group, both Halliburton and Texaco did especially well.
Texaco's stock benefited from the company's restructuring, as well as an
improved outlook for production from new oil fields in Mexico and the North Sea.
Similarly, investors rewarded Halliburton for its restructuring, improving
fundamentals and naming a new CEO. By contrast, Exxon, the Fund's largest
investment, just kept pace with the market, despite the company's strong
management, worldwide exposure and solid chemical operation.

     Although electric utilities -- about 10% of the Fund's investments --
usually benefit from falling interest rates, some of our utilities did not do as
well as we'd hoped. Baltimore Gas and Electric's stock price suffered from
concerns that its planned merger with Potomac Electric might not be approved.
And Pacific Gas & Electric did poorly due to uncertainties about what kind of
rate decreases California regulatory authorities might impose. Nevertheless, we
still believe both stocks have strong prospects.

Outlook

With continued low inflation and moderate economic growth, the stock market
could continue to deliver decent returns. But it's unlikely they'll approach
1995's stellar performance. Regardless of what happens, we'll keep looking for
cheap stocks with improving prospects. In the process, we'll continually adjust
our earnings and growth estimates to reflect changing market and economic
conditions. New telecommunications legislation, for example, recently made long
distance telephone carriers attractive. That's the kind of opportunity we'll be
looking for.



                                       17

<PAGE>

                             A LOOK AT PERFORMANCE


<TABLE>
The table on the right shows the cumulative total return for the John Hancock
Independence Value Fund. Total return is a performance measure that equals the
sum of all income and capital gains dividends, assuming reinvestment of these
distributions, and the change in the price of the Fund's shares, expressed as a
percentage of the Fund's net asset value per share. Remember that all figures
represent past performance and are no guarantee of how the Fund will perform in
the future. Also, keep in mind that the total return and share price of the
Fund's investments will fluctuate. As a result, your Fund's shares may be worth
more or less than their original cost, depending on when you sell them.

                            CUMULATIVE TOTAL RETURN

<CAPTION>
For the period ended December 31, 1995


                                                                   LIFE OF
                                                                     FUND
                                                                     ----

<S>                                                                  <C>   
John Hancock Independence Value Fund(1)                              7.77% 



                              Notes to Performance
(1) Commenced on October 2, 1995.
</TABLE>



                                       18

<PAGE>

                   WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Independence Value Fund would be worth on February 29, 1996, assuming you
invested on the day the Fund started and have reinvested all distributions. For
comparison, we've shown the same $250,000 investment in the Russell 1000 Value
Index -- an unmanaged capitalization-weighted price-only index, which is
comprised of 1,000 of the largest capitalized U.S. domiciled companies whose
common stock traded in the United States on the New York Stock Exchange. The
securities in this index have less than average growth orientation.

[CHART: Line chart with the heading Independence Value Fund, representing the
growth of a hypothetical $250,000 investment over the life of the fund. Within
the chart are two lines.

The first line represents the value of the hypothetical $250,000 investment made
in the Independence Value Fund on October 2, 1995 and is equal to $281,299 as of
February 29, 1996. The second line represents the value of the Russell 1000
Value Index and is equal to $276,975 as of February 29, 1996.]


                                       19

<PAGE>

               BY PAUL MCMANUS FOR THE PORTFOLIO MANAGEMENT TEAM

                                  John Hancock
                            Independence Diversified
                              Core Equity Fund II

                Strong corporate earnings and soaring bull market
                -------------------------------------------------
                             mark Fund's first year
                             ----------------------

[CALL OUT -- LEFT SIDE]
"Our stocks come from across a vast range of industries..."

The near-ideal market conditions that existed when the Fund was launched on
March 10, 1995 prevailed throughout its first fiscal year. The period was marked
by a slow-growing economy, declining interest rates, muted inflation and strong
corporate earnings. The result was a strongly advancing market and a solid
return for the Fund's first fiscal year. From its opening through February 29,
1996, the Fund posted a total return of 30.48% at net asset value. During the
same period, the average growth and income fund returned 29.32%, according to
Lipper Analytical Services, and the Standard & Poor's 500-Stock Index returned
33.93%.

Strategy and
top performers

The Fund takes a bottom-up approach to investing. That simply means that we
don't make bets on market sectors, but instead build the portfolio
stock-by-stock based on individual merit. Using our team of analysts and
computer valuation models, we choose the best stocks that combine our two
selection criteria: value and improving fundamentals. Our stocks come from
across a vast range of industries and company types to create a portfolio that
reflects the risk profile and characteristics of our benchmark S&P 500-Stock
Index. During the Fund's first fiscal year, some of its top performers were in
the telecommunications, technology and aerospace groups. Our financial and
pharmaceutical companies were also steady performers.

     Telecommunications companies are reaping the rewards of some major changes
in their industry, in particular the recent passage of a major

[PHOTO: A 2 1/2" x 2 1/2" photo of Paul McManus centered at bottom. Caption
reads: "Paul McManus."]

                                       20

<PAGE>

               John Hancock Funds - Institutional Series Trust --
                  Independence Diversified Core Equity Fund II

"...there's still room for the market to advance, even at a slower rate."

[CHART: Bar chart with the heading "Fund Performance" at top left hand column. A
footnote below states "For the period March 10, 1995 through February 29, 1996."
The chart is scaled in increments of 10% from bottom to top, with 40% at the top
and 0% at the bottom. Within the chart, there are three solid bars. The first
represents the 30.48% total return for John Hancock Independence Diversified
Core Equity II. The second represents the 29.32% total return for the average
growth and income fund. The third represents the 33.93% total return for the S&P
500-Stock Index. A footnote below states: "The total return for John Hancock
Independence Diversified Core Equity II is at net asset value with all
distributions reinvested. The average growth and income fund is tracked by
Lipper Analytical Services. The S&P 500-Stock Index is an unmanaged index that
includes 500 widely-traded common stocks. See following page for historical
performance information."]

telecommunications bill that fosters competition. While we still don't know the
bill's full impact, in our view, the long-line carriers such as Fund holdings
AT&T and GTE are better positioned from a cost perspective to benefit from the
new bill than the higher-cost local Bell operating companies. AT&T has already
taken steps to position itself by splitting into three companies and, despite
criticism for its announced layoffs, the company's stock charged forward in the
period.

     Technology stocks, the darlings of the 1995 rally, served us well,
especially in the first half of the period when earnings momentum was at its
height. In late summer, tech stocks experienced some pullback, especially the
semiconductor companies as supply began to catch up to demand. While the Fund
felt the effect, it was moderated by the fact that by then, we were
underweighted in the sector, having taken profits on some high flyers earlier
on. As prices came down, we began to increase or add to our technology holdings
across several subsectors, including Microsoft, Texas Instruments, Integrated
Device Technologies and Komag, a disc-drive company with strong fundamentals and
an attractive price. Another addition was Analog Devices, a specialty
semiconduct or company whose stock rose after we bought it in the second half
despite the sector's overall decline.

     Our aerospace stocks turned in strong showings, including Lockheed, which
continues to generate excess cash, and Boeing, which benefited from an
anticipated increase in airplane orders on the heels of improvement in the
airline industry. Not surprisingly, the cyclical companies -- those such as
paper, forest product and automobile-related companies that are more vulnerable
to a slow economy -- lagged during the period.

Outlook

After the market's 1995 performance, it would be unrealistic to expect more of
the same this year. However, as long as interest rates stay low or fall, and the
economy continues its slow-growth mode, there's still room for the market to
advance, even at a slower rate. Politics will be key this year in determining
which direction the market takes. We'll be watching to see whether, once
campaigning ends, there is a renewed effort to balance the federal budget. That
would send a positive message to the market and possibly prompt lower interest
rates. Whatever happens, we'll stick to our disciplined investment style of
finding reasonably priced companies that have improving prospects. It's the way
we know best to add value over the long term.



                                       21

<PAGE>
                             A LOOK AT PERFORMANCE


<TABLE>
The table on the right shows the cumulative total return for the John Hancock
Independence Diversified Core Equity Fund II. Total return is a performance
measure that equals the sum of all income and capital gains dividends, assuming
reinvestment of these distributions, and the change in the price of the Fund's
shares, expressed as a percentage of the Fund's net asset value per share.
Remember that all figures represent past performance and are no guarantee of how
the Fund will perform in the future. Also, keep in mind that the total return
and share price of the Fund's investments will fluctuate. As a result, your
Fund's shares may be worth more or less than their original cost, depending on
when you sell them.

                            CUMULATIVE TOTAL RETURN

<CAPTION>
For the period ended December 31, 1995

                                                                  LIFE OF
                                                                    FUND
                                                                    ----

<S>                                                                <C>   
John Hancock Independence Diversified Core Equity Fund II(1)       25.84%



                              Notes to Performance
(1) Commenced on March 10, 1995.
</TABLE>



                                       22

<PAGE>

                   WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Independence Diversified Core Equity Fund II would be worth on February 29,
1996, assuming you invested on the day the Fund started and have reinvested all
distributions. For comparison, we've shown the same $250,000 investment in the
Standard & Poor's 500 Stock Index -- an unmanaged index that includes 500 widely
traded common stocks and is often used as a measure of stock market performance.

[CHART: Line chart with the heading Independence Diversified Core Equity Fund
II, representing the growth of a hypothetical $250,000 investment over the life
of the fund. Within the chart are two lines.

The first line represents the value of the Standard and Poor's 500 Stock Index
and is equal to $327,024 as of February 29, 1996. The second line represents the
value of the hypothetical $250,000 investment made in the Independence
Diversified Core Equity Fund II on March 10, 1995 and is equal to $326,197 as of
February 29, 1996.]

                                       23

<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Assets and Liabilities
February 29, 1996
- ---------------------------------------------------------------------------------------------------------------------------

<CAPTION>
                                                                                           INDEPENDENCE        INDEPENDENCE
                                                                                           BALANCED FUND       GROWTH FUND
                                                                                           -------------       -----------

<S>                                                                                         <C>                  <C>     
Assets:
  Investments at value - Note C:
    Common stocks (cost - $2,348,623 and $500,016, respectively)                            $2,546,331           $544,806
    Corporate bonds (cost - $31,930 and none, respectively)                                     30,885                 --
    U.S. government and agencies securities (cost - $2,524,743 and none, respectively).      2,498,594                 --
    Short-term investments (cost - $88,000 and $5,000, respectively)                            88,000              5,000
    Corporate savings account                                                                      444                773
                                                                                            ----------           --------
                                                                                             5,164,254            550,579
  Receivable for investments sold                                                                4,448                 --
  Dividends receivable                                                                           7,848                874
  Interest receivable                                                                           40,250                 --
  Receivable from John Hancock Advisers, Inc. - Note B                                          68,683             80,327
  Other assets                                                                                     188                 --
  Deferred organization expenses - Note A                                                        8,147              8,016
                                                                                            ----------           --------
          Total Assets                                                                       5,293,818            639,796
          ---------------------------------------------------------------------------------------------------------------

Liabilities:
  Payable for shares repurchased                                                                21,934                 --
  Payable for investments purchased                                                             31,046                 --
  Payable to John Hancock Advisers, Inc. and affiliates - Note B                                13,322             10,549
  Accounts payable and accrued expenses                                                         72,582             79,820
                                                                                            ----------           --------
          Total Liabilities                                                                    138,884             90,369
          ---------------------------------------------------------------------------------------------------------------

Net Assets:
  Capital paid-in                                                                            4,935,225            503,059
  Accumulated net realized gain on investments                                                  20,423              1,578
  Net unrealized appreciation of investments                                                   170,514             44,790
  Undistributed net investment income                                                           28,772                 --
                                                                                            ----------           --------
          Net Assets                                                                        $5,154,934           $549,427
          ===============================================================================================================

Net Asset Value Per Share:
  (based on 557,295 and 59,172 shares, respectively, of beneficial interest outstanding -
  unlimited number of shares authorized with no par value)                                  $     9.25           $   9.29
  =======================================================================================================================
 
</TABLE>

The Statement of Assets and Liabilities is each Fund's balance sheet and shows
the value of what the Fund owns, is due and owes as of February 29,
1996. You'll also find the net asset value per share as of that date.


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       24

<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Assets and Liabilities
February 29, 1996
- -----------------------------------------------------------------------------------------------------------------------------------

<CAPTION>
                                                                                                 INDEPENDENCE
                                                                                                    MEDIUM          INDEPENDENCE
                                                                                              CAPITALIZATION FUND    VALUE FUND
                                                                                              -------------------   ------------

<S>                                                                                               <C>                <C>     
Assets:
  Investments at value - Note C:
    Common stocks (cost - $3,546,872 and $618,673, respectively)                                  $3,838,606         $676,256
    Short-term investments (cost - $99,000 and $10,000, respectively)                                 99,000           10,000
    Corporate savings account                                                                            404            3,192
                                                                                                  ----------         --------
                                                                                                   3,938,010          689,448

  Receivable for investments sold                                                                         --           10,683
  Dividends receivable                                                                                10,234            2,958
  Interest receivable                                                                                     27                5
  Receivable from John Hancock Advisers, Inc. - Note B                                                48,525           76,973
  Other assets                                                                                           127               --
  Deferred organization expenses - Note A                                                              8,016            8,016
                                                                                                  ----------         --------
          Total Assets                                                                             4,004,939          788,083
          -------------------------------------------------------------------------------------------------------------------

Liabilities:
  Payable for investments purchased                                                                       --           18,985
  Payable to John Hancock Advisers, Inc. and affiliates - Note B                                      11,820           10,710
  Accounts payable and accrued expenses                                                               70,211           76,485
                                                                                                  ----------         --------
          Total Liabilities                                                                           82,031          106,180
          -------------------------------------------------------------------------------------------------------------------

Net Assets:
  Capital paid-in                                                                                  3,626,554          619,905
  Accumulated net realized gain (loss) on investments                                                 (4,647)           3,145
  Net unrealized appreciation of investments                                                         291,734           57,583
  Undistributed net investment income                                                                  9,267            1,270
                                                                                                  ----------         --------
          Net Assets                                                                              $3,922,908         $681,903
          ===================================================================================================================

Net Asset Value Per Share:
  (based on 422,379 and 71,972 shares, respectively, of beneficial interest outstanding -
  unlimited number of shares authorized with no par value)                                        $     9.29         $   9.47
  ===========================================================================================================================
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       25

<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Assets and Liabilities
February 29, 1996
- --------------------------------------------------------------------------------------------------

<CAPTION>
                                                                              INDEPENDENCE
                                                                            DIVERSIFIED CORE
                                                                             EQUITY FUND II
                                                                            ----------------

<S>                                                                             <C>         
Assets:
  Investments at value - Note C:
    Common stocks (cost - $163,762,530)                                         $186,013,110
    Short-term investments (cost - $2,343,000)                                     2,343,000
    Corporate savings account                                                            583
                                                                                ------------
                                                                                 188,356,693

  Receivable for shares sold                                                          15,422
  Dividends receivable                                                               535,567
  Foreign tax receivable                                                               1,108
  Interest receivable                                                                    688
  Receivable from John Hancock Advisers, Inc. - Note B                                31,754
  Other assets                                                                         6,062
  Deferred organization expenses - Note A                                              7,631
                                                                                ------------
      Total Assets                                                               188,954,925
      --------------------------------------------------------------------------------------

Liabilities:
  Payable for shares repurchased                                                      22,768
  Payable to John Hancock Advisers, Inc. and affiliates - Note B                     109,367
  Accounts payable and accrued expenses                                              144,200
                                                                                ------------
      Total Liabilities                                                              276,335
      --------------------------------------------------------------------------------------

Net Assets:
  Capital paid-in                                                                164,482,855
  Accumulated net realized gain on investments and foreign currenc transactions    1,357,757
  Net unrealized appreciation of investments                                      22,250,580
  Undistributed net investment income                                                587,398
                                                                                ------------
      Net Assets                                                                $188,678,590
      ======================================================================================

Net Asset Value Per Share:
  (based on 17,214,404 shares of beneficial interest outstanding - unlimited
  number of shares authorized with no par value)                                $      10.96
  ==========================================================================================
  
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       26

<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Operations
Period ended February 29, 1996*
- ------------------------------------------------------------------------------------------------------------

<CAPTION>
                                                                            INDEPENDENCE        INDEPENDENCE
                                                                            BALANCED FUND       GROWTH FUND
                                                                            -------------       ------------

<S>                                                                           <C>                <C>    
Investment Income:
  Dividends (net of foreign withholding tax of $83 and none, respectively)    $ 22,351           $  3,537
  Interest                                                                      60,233                426
                                                                              --------           --------
                                                                                82,584              3,963
  Expenses:
    Registration and filing fees                                                58,256             61,477
    Investment management fee - Note B                                          11,878              1,704
    Auditing fee                                                                11,500             11,500
    Custodian fee                                                                5,490              4,165
    Printing                                                                     4,532              2,164
    Organization expense - Note A                                                1,226                723
    Transfer agent fee - Note B                                                    848                107
    Trustees' fees                                                                 496                 50
    Legal fees                                                                     372                404
    Financial services fee - Note B                                                160                 16
    Miscellaneous                                                                  126                 59
                                                                              --------           --------
      Total Expenses                                                            94,884             82,369
      Less Expense Reimbursements and Reductions - Note B                      (79,593)           (80,343)
                                                                              --------           --------
      Net Expenses                                                              15,291              2,026
      ---------------------------------------------------------------------------------------------------
      Net Investment Income                                                     67,293              1,937
      ---------------------------------------------------------------------------------------------------

Realized and Unrealized Gain on Investments:
  Net realized gain on investments sold                                         20,423              2,701
  Change in net unrealized appreciation/depreciation of investments            170,514             44,790
                                                                              --------           --------
      Net Realized and Unrealized Gain on Investments                          190,937             47,491
      ---------------------------------------------------------------------------------------------------
      Net Increase in Net Assets Resulting from Operations                    $258,230           $ 49,428
      ===================================================================================================   
      

* Independence Balanced Fund and Independence Growth Fund commenced operations on July 6, 1995 and 
  October 2, 1995, respectively.
</TABLE>


The Statement Of Operations summarizes for each of the Funds, the investment
income earned and expenses incurred in operating the Fund. It also shows net
gains (losses) for the period stated.

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       27

<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Operations
Period ended February 29, 1996*
- --------------------------------------------------------------------------------------------------------------

<CAPTION>
                                                                             INDEPENDENCE
                                                                                MEDIUM            INDEPENDENCE 
                                                                          CAPITALIZATION FUND      VALUE FUND
                                                                          -------------------     ------------

<S>                                                                              <C>                 <C>     
Investment Income:
  Dividends                                                                      $ 25,988            $  8,146
  Interest                                                                          7,777                 584
                                                                                 --------            -------- 
                                                                                   33,765               8,730
                                                                                 --------            --------

  Expenses:
    Registration and filing fees                                                   56,134              57,767
    Auditing fee                                                                   11,500              11,500
    Investment management fee - Note B                                              9,177               1,855
    Custodian fee                                                                   4,984               4,165
    Printing                                                                        2,751               2,539
    Organization expense - Note A                                                     723                 723
    Transfer agent fee - Note B                                                       574                 116
    Legal fees                                                                        416                 405
    Trustees' fees                                                                    385                  50
    Financial services fee - Note B                                                   116                  20
    Miscellaneous                                                                     104                  59
                                                                                 --------            --------
      Total Expenses                                                               86,864              79,199
      Less Expense Reimbursements and Reductions - Note B                         (75,379)            (76,993)
                                                                                 --------            --------
      Net Expenses                                                                 11,485               2,206
      -------------------------------------------------------------------------------------------------------
      Net Investment Income                                                        22,280               6,524

Realized and Unrealized Gain (Loss) on Investments:
  Net realized gain (loss) on investments sold                                     (4,647)              3,145
  Change in net unrealized appreciation/depreciation of investments               291,734              57,583
                                                                                 --------            --------
      Net Realized and Unrealized Gain on Investments                             287,087              60,728
      -------------------------------------------------------------------------------------------------------
      Net Increase in Net Assets Resulting from Operations                       $309,367            $ 67,252
      =======================================================================================================

* Independence Medium Capitalization Fund and Independence Value Fund commenced operations on 
  October 2, 1995, respectively.
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       28



<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Operations
Period ended February 29, 1996*
- ------------------------------------------------------------------------------------------------

<CAPTION>
                                                                                            INDEPENDENCE  
                                                                                          DIVERSIFIED CORE
                                                                                           EQUITY FUND II 
                                                                                          ----------------
                                                                                             
<S>                                                                                           <C>        
Investment Income:    
  Dividends (net of foreign withholding tax of $11,178)                                        $ 2,572,006
  Interest                                                                                         156,903
                                                                                               -----------
                                                                                                 2,728,909
  Expenses:
    Investment management fee - Note B                                                             504,982
    Registration and filing fees                                                                   116,406
    Custodian fee                                                                                   57,145
    Transfer agent fee - Note B                                                                     50,498
    Trustees' fees                                                                                  16,701
    Auditing fee                                                                                    11,500
    Financial services fee -  Note B                                                                 5,556
    Printing                                                                                         2,954
    Miscellaneous                                                                                    2,274
    Organization expense - Note A                                                                    1,856
    Legal fees                                                                                       1,543
                                                                                               -----------
          Total Expenses                                                                           771,415
          Less Expense Reimbursements and Reductions - Note B                                      (63,083)
                                                                                               -----------
          Net Expenses                                                                             708,332
          ------------------------------------------------------------------------------------------------
          Net Investment Income                                                                  2,020,577
          ------------------------------------------------------------------------------------------------

Realized and Unrealized Gain on Investments and Foreign Currency Transactions:
  Net realized gain on investments sold and foreign currency transactions                        1,499,534
  Change in net unrealized appreciation/depreciation of investments                             22,250,580
          Net Realized and Unrealized Gain on Investments and Foreign Currency Transactions     23,750,114
          ------------------------------------------------------------------------------------------------
          Net Increase in Net Assets Resulting from Operations                                 $25,770,691
          ===============================================================================================-
          

* Independence Diversified Core Equity Fund II commenced operations on March 10, 1995.
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       29

<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Changes in Net Assets
- ----------------------------------------------------------------------------------------------------------------------

                                                                                                INDEPENDENCE       INDEPENDENCE    
                                                                                                BALANCED FUND      GROWTH FUND     
                                                                                                -------------      ------------    
                                                                                                PERIOD ENDED       PERIOD ENDED    
                                                                                              FEBRUARY 29, 1996  FEBRUARY 29, 1996 
                                                                                              -----------------  ----------------- 
                                                                                
<S>                                                                                                  <C>              <C>       
Increase (Decrease) in Net Assets:                                                                      
From Operations:                                                                                        
  Net investment income                                                                              $   67,293       $    1,937
  Net realized gain on investments sold                                                                  20,423            2,701
  Change in net unrealized appreciation/depreciation of investments                                     170,514           44,790
                                                                                                     ----------       ----------
    Net Increase in Net Assets Resulting from Operations                                                258,230           49,428
                                                                                                     ----------       ----------
Distributions to Shareholders: *                                                                        
  Dividends from net investment income                                                                  (38,521)          (1,937)
  Distributions from net realized short-term gain on investments sold                                         0           (1,123)
                                                                                                     ----------       ----------
    Total Distributions to Shareholders                                                                 (38,521)          (3,060)
                                                                                                     ----------       ----------
From Fund Share Transactions: **                                                                        
  Shares sold                                                                                         5,415,754          500,075
  Shares issued to shareholders in reinvestment of distributions                                         38,522            3,060
                                                                                                     ----------       ----------
                                                                                                      5,454,276          503,135
  Less shares repurchased                                                                              (519,051)             (76)
                                                                                                     ----------       ----------
    Net increase                                                                                      4,935,225          503,059
                                                                                                     ----------       ----------
                                                                                                        
Net Assets:                                                                                             
  Beginning of period                                                                                         0                0
                                                                                                     ----------       ----------
  End of period (including undistributed net investment income of $28,772 and none, respectively)    $5,154,934       $  549,427
                                                                                                     ==========       ==========
                                                                                                        
* Distributions to Shareholders                                                                         
  Per share dividends from net investment income                                                     $   0.1300       $   0.0329
                                                                                                     ----------       ----------
  Per share distributions from net realized short-term gain on investments sold                               0       $   0.0191
                                                                                                     ----------       ----------
                                                                                                        
** Analysis of Fund Share Transactions:                                                                 
  Shares sold                                                                                           609,416           58,832
  Shares issued to shareholders in reinvestment of distributions                                          4,250              348
                                                                                                     ----------       ----------
                                                                                                        613,666           59,180
  Less shares repurchased                                                                               (56,371)              (8)
                                                                                                     ----------       ----------
    Net increase                                                                                        557,295           59,172
                                                                                                     ==========       ==========
                                                                                                     

[dagger] Independence Balanced Fund and Independence Growth Fund commenced Operations on July 6, 1995 and 
         October 2, 1995, respectively.
</TABLE>

The Statement of Changes in Net Assets shows how the value of each Fund's net
assets has changed since the commencement of operations. The difference reflects
net investment income, any investment gains and losses, distributions paid to
shareholders, and any increase or decrease in money shar eholders invested in
each Fund. The footnotes illustrate the number of Fund shares sold, reinvested
and redeemed during the period, along with the per share amount of distributions
made to shareholders of each Fund for the period indicated.

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       30

<PAGE>


                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Changes in Net Assets
- -------------------------------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                 INDEPENDENCE
                                                                                     MEDIUM                 INDEPENDENCE
                                                                               CAPITALIZATION FUND           VALUE FUND
                                                                               -------------------        -----------------
                                                                                 PERIOD ENDED               PERIOD ENDED
                                                                               FEBRUARY 29, 1996          FEBRUARY 29, 1996
                                                                               -------------------        -----------------
<S>                                                                               <C>                         <C>
Increase (Decrease) in Net Assets:
From Operations:
  Net investment income                                                           $   22,280                  $  6,524
  Net realized gain (loss) on investments sold                                        (4,647)                    3,145
  Change in net unrealized appreciation/depreciation of investments                  291,734                    57,583
                                                                                  ----------                  --------
    Net Increase in Net Assets Resulting from Operations                             309,367                    67,252
                                                                                  ----------                  --------

Distributions to Shareholders: *
  Dividends from net investment income                                               (13,013)                   (5,254)
                                                                                  ----------                  --------

From Fund Share Transactions: **
  Shares sold                                                                      3,855,325                   615,732
  Shares issued to shareholders in reinvestment of distributions                      13,012                     5,254
                                                                                  ----------                  --------
                                                                                   3,868,337                   620,986
  Less shares repurchased                                                           (241,783)                   (1,081)
                                                                                  ----------                  --------
    Net increase                                                                   3,626,554                   619,905
                                                                                  ----------                  --------

Net Assets:
  Beginning of period                                                                    ---                       ---
  End of period (including undistributed net investment income of 
    $9,267 and $1,270, respectively)                                              $3,922,908                  $681,903
                                                                                  ==========                  ========

* Distributions to Shareholders
  Per share dividends from net investment income                                  $   0.0333                  $ 0.0893
                                                                                  ----------                  --------

** Analysis of Fund Share Transactions:
  Shares sold                                                                        448,130                    71,507
  Shares issued to shareholders in reinvestment of distributions                       1,480                       585
                                                                                  ----------                  --------
                                                                                     449,610                    72,092
  Less shares repurchased                                                            (27,231)                     (120)
                                                                                  ----------                  --------
    Net increase                                                                     422,379                    71,972
                                                                                  ==========                  ========

[dagger] Independence Medium Capitalization Fund and Independence Value Fund commenced operations 
         on October 2, 1995, respectively.

</TABLE>
                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       31

<PAGE>


                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Changes in Net Assets
- --------------------------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                                            INDEPENDENCE
                                                                                                             DIVERSIFIED
                                                                                                           EQUITY FUND II
                                                                                                         -----------------
                                                                                                            PERIOD ENDED
                                                                                                         FEBRUARY 29, 1996
                                                                                                         -----------------
<S>                                                                                                         <C>             
Increase (Decrease) in Net Assets:
From Operations:
  Net investment income                                                                                     $   2,020,577
  Net realized gain on investments sold and foreign currency transactions                                       1,499,534
  Change in net unrealized appreciation/depreciation of investments                                            22,250,580
                                                                                                            -------------
    Net Increase in Net Assets Resulting from Operations                                                       25,770,691
                                                                                                            -------------

Distributions to Shareholders: *
  Dividends from net investment income                                                                         (1,434,011)
    Distributions from net realized short-term gain on investments sold and foreign currency transactions        (140,945)
                                                                                                            -------------

      Total Distributions to Shareholders                                                                      (1,574,956)
                                                                                                            -------------


From Fund Share Transactions: **
  Shares sold                                                                                                 174,862,644
  Shares issued to shareholders in reinvestment of distributions                                                1,574,424
                                                                                                            -------------
                                                                                                              176,437,068
  Less shares repurchased                                                                                     (11,954,213)
                                                                                                            -------------
    Net increase                                                                                              164,482,855
                                                                                                            -------------

Net Assets:
    Beginning of period                                                                                               ---
                                                                                                            -------------
    End of period (including undistributed net investment income of $587,398)                               $ 188,678,590
                                                                                                            =============

* Distributions to Shareholders
    Per share dividends from net investment income                                                          $      0.1113
                                                                                                            -------------
    Per share distributions from net realized short-term gain on investments sold and
       foreign currency transactions                                                                        $      0.0090
                                                                                                            -------------


** Analysis of Fund Share Transactions:
  Shares sold                                                                                                  18,245,546
  Shares issued to shareholders in reinvestment of distributions                                                  153,808
                                                                                                            -------------
                                                                                                               18,399,354
  Less shares repurchased                                                                                      (1,184,950)
                                                                                                            -------------
    Net increase                                                                                               17,214,404
                                                                                                            =============



[dagger] Independence Diversified Core Equity Fund II commenced operations on March 10, 1995.
</TABLE>


                                       
                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       32

<PAGE>


                              FINANCIAL STATEMENTS

  John Hancock Funds - Institutional Series Trust -- Independence Balanced Fund

<TABLE>
Financial Highlights 
The following table includes selected data for a share outstanding 
throughout the period, total investment return, key ratios and supplemental data.
- ---------------------------------------------------------------------------------------
<CAPTION>

                                                                                                   
                                                             THE PERIOD JULY 6, 1995
                                                           (COMMENCEMENT OF OPERATIONS)
                                                               TO FEBRUARY 29, 1996
                                                           ----------------------------
<S>                                                                     <C>
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                  $ 8.50(a)
                                                                        ------
  Net Investment Income                                                   0.25
  Net Realized and Unrealized Gain on Investments                         0.63
                                                                        ------
    Total from Investment Operations                                      0.88
                                                                        ------

  Less Distributions:
    Dividends from Net Investment Income                                 (0.13)
                                                                        ------
  Net Asset Value, End of Period                                        $ 9.25
                                                                        ======
  Total Investment Return at Net Asset Value (e)                         10.42%(c)
  Total Adjusted Investment Return at Net Asset Value (b)(e)              7.36%(c)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                             $5,155
  Ratio of Expenses to Average Net Assets                                 0.90%*
  Ratio of Adjusted Expenses to Average Net Assets (b)(d)                 5.58%*
  Ratio of Net Investment Income to Average Net Assets                    3.96%*
  Ratio of Adjusted Net Investment Loss to Average Net Assets (b)(d)     (0.72%)*
  Portfolio Turnover Rate                                                   31%


  * On an annualized basis.
(a) Initial price to commence operations.
(b) On an unreimbursed basis.
(c) Not annualized.
(d) Adjusted expenses as a percentage of average net assets are expected to
    decrease and adjusted net investment income as a percentage of average net
    assets are expected to increase as the net assets of the Fund grow. 
(e) Total investment return assumes dividend reinvestment. 
</TABLE>



The Financial Highlights summarizes the impact of the following factors on a
single share for the period indicated: net investment income, gains (losses),
dividends and total investment return of the Fund. It shows how the Fund's net
asset value for a share has changed since the commencement of operations.
Additionally, important relationships between some items presented in the
financial statements are expressed in ratio form.


                                       
                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       33

<PAGE>


                              FINANCIAL STATEMENTS

   John Hancock Funds - Institutional Series Trust -- Independence Growth Fund

<TABLE>
Financial Highlights 
The following table includes selected data for a share outstanding throughout the period, 
total investment return, key ratios and supplemental data.
- -----------------------------------------------------------------------------------------
<CAPTION>
                                                                                                
                                                           FOR THE PERIOD OCTOBER 2, 1995
                                                             (COMMENCEMENT OF OPERATIONS)
                                                                  TO FEBRUARY 29, 1996
                                                           -------------------------------

<S>                                                                        <C>
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                     $  8.50(a)
                                                                           -------
  Net Investment Income                                                       0.03(e)
  Net Realized and Unrealized Gain on Investments                             0.81
                                                                           -------
    Total from Investment Operations                                          0.84
                                                                           -------
  Less Distributions:
  Dividends from Net Investment Income                                       (0.03)
  Distributions from Net Realized Short-Term Gain on Investments             (0.02)
                                                                           -------
    Total Distributions                                                      (0.05)
                                                                           -------
  Net Asset Value, End of Period                                           $  9.29
                                                                           =======
  Total Investment Return at Net Asset Value (f)                              9.94%(c)
  Total Adjusted Investment Return at Net Asset Value (b)(f)                 (5.63%)(c)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                                $   549
  Ratio of Expenses to Average Net Assets                                     0.95%*
  Ratio of Adjusted Expenses to Average Net Assets (b)(d)                    38.57%*
  Ratio of Net Investment Income to Average Net Assets                        0.91%*
  Ratio of Adjusted Net Investment Loss to Average Net Assets (b)(d)        (36.71%)*
  Portfolio Turnover Rate                                                       21%

  * On an annualized basis.
(a) Initial price to commence operations.
(b) On an unreimbursed basis.
(c) Not annualized.
(d) Adjusted expenses as a percentage of average net assets are expected to 
    decrease and adjusted net investment income as a percentage of average net 
    assets is expected to increase as the net assets of the Fund grow.
(e) On average month end shares outstanding.
(f) Total investment return assumes dividend reinvestment.
</TABLE>

                                       
                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       34

<PAGE>


                              FINANCIAL STATEMENTS

John Hancock Funds - Institutional Series Trust -- Independence Medium 
Capitalization

<TABLE>
Financial Highlights
The following table includes selected data for a share outstanding throughout the period, 
total investment return, key ratios and supplemental data.
- ------------------------------------------------------------------------------------------
<CAPTION>

                                                            FOR THE PERIOD OCTOBER 2, 1995
                                                            (COMMENCEMENT OF OPERATIONS)
                                                                 TO FEBRUARY 29, 1996
                                                            ------------------------------
<S>                                                                       <C>
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                    $ 8.50(a)
                                                                          ------
  Net Investment Income                                                     0.08(c)
  Net Realized and Unrealized Gain on Investments                           0.74
                                                                          ------
    Total from Investment Operations                                        0.82
                                                                          ------

  Less Distributions:
    Dividends from Net Investment Income                                   (0.03)
                                                                          ------
  Net Asset Value, End of Period                                          $ 9.29
                                                                          ======
  Total Investment Return at Net Asset Value (e)                            9.71%(d)
  Total Adjusted Investment Return at Net Asset Value (b)(e)                7.00%(d)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                               $3,923
  Ratio of Expenses to Average Net Assets                                   1.00%*
  Ratio of Adjusted Expenses to Average Net Assets (b)                      7.55%*
  Ratio of Net Investment Income to Average Net Assets                      1.94%*
  Ratio of Adjusted Net Investment Loss to Average Net Assets (b)          (4.61%)*
  Portfolio Turnover Rate                                                      3%

  * On an annualized basis.
(a) Initial price to commence operations.
(b) On an unreimbursed basis.
(c) On average month end shares outstanding.
(d) Not annualized.
(e) Total investment return assumes dividend reinvestment.
</TABLE>

                                       
                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       35

<PAGE>


                              FINANCIAL STATEMENTS

John Hancock Funds - Institutional Series Trust -- Independence Value Fund

<TABLE>
Financial Highlights 
The following table includes selected data for a share outstanding throughout the period, 
total investment return, key ratios and supplemental data.
- ------------------------------------------------------------------------------------------------
<CAPTION>
                                                                  FOR THE PERIOD OCTOBER 2, 1995
                                                                   (COMMENCEMENT OF OPERATIONS)
                                                                       TO FEBRUARY 29, 1996
                                                                  ------------------------------
<S>                                                                         <C>
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                      $ 8.50(a)
                                                                            ------  
  Net Investment Income                                                       0.10(e)
  Net Realized and Unrealized Gain on Investments                             0.96
                                                                            ------
    Total from Investment Operations                                          1.06
                                                                            ------
  Less Distributions:
    Dividends from Net Investment Income                                     (0.09)
                                                                           -------
  Net Asset Value, End of Period                                           $  9.47
                                                                           =======
  Total Investment Return at Net Asset Value (f)                             12.52%(c)
  Total Adjusted Investment Return at Net Asset Value (b)(f)                 (1.18%)(c)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                                $   682
  Ratio of Expenses to Average Net Assets                                     0.95%*
  Ratio of Adjusted Expenses to Average Net Assets (b)(d)                    34.06%*
  Ratio of Net Investment Income to Average Net Assets                        2.81%*
  Ratio of Adjusted Net Investment Loss to Average Net Assets (b)(d)        (30.30%)*
  Portfolio Turnover Rate                                                       12%


  * On an annualized basis.
(a) Initial price to commence operations.
(b) On an unreimbursed basis.
(c) Not annualized.
(d) Adjusted expenses as a percentage of average net assets are expected to decrease 
    and adjusted net investment income as a percentage of average net assets are 
    expected to increase as the net assets of the Fund grow.
(e) On average month end shares outstanding.
(f) Total investment return assumes dividend reinvestment.
</TABLE>

                                       
                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       36

<PAGE>


                              FINANCIAL STATEMENTS

John Hancock Funds - Institutional Series Trust -- Independence Diversified Core
Equity Fund

<TABLE>
Financial Highlights 
The following table includes selected data for a share outstanding throughout the period, 
total investment return, key ratios and supplemental data.
- -----------------------------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                                FOR THE PERIOD MARCH 10, 1995
                                                                                                 (COMMENCEMENT OF OPERATIONS)
                                                                                                      TO FEBRUARY 29, 1996
                                                                                                -----------------------------
<S>                                                                                                     <C>
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                                                  $   8.50(a)
                                                                                                        --------
  Net Investment Income                                                                                     0.20(c)
  Net Realized and Unrealized Gain on Investments and Foreign Currency Transactions                         2.38
                                                                                                        --------
    Total from Investment Operations                                                                        2.58
                                                                                                        --------

  Less Distributions:
    Dividends from Net Investment Income                                                                   (0.11)
    Distributions from Net Realized Gains on Investments Sold and Foreign Currency Transactions            (0.01)
                                                                                                        --------
    Total Distributions                                                                                    (0.12)
                                                                                                        --------
  Net Asset Value, End of Period                                                                        $  10.96
                                                                                                        ========
  Total Investment Return at Net Asset Value (e)                                                           30.48%(d)
  Total Adjusted Investment Return at Net Assets Value (b)(e)                                              30.42%(d)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                                                             $188,679
  Ratio of Expenses to Average Net Assets                                                                   0.70%*
  Ratio of Adjusted Expenses to Average Net Assets (b)                                                      0.76%*
  Ratio of Net Investment Income to Average Net Assets                                                      2.00%*
  Ratio of Adjusted Net Investment Income to Average Net Assets (b)                                         1.94%*
  Portfolio Turnover Rate                                                                                     39%

  * On an annualized basis.
(a) Initial price to commence operations.
(b) On an unreimbursed basis.
(c) On average month end shares outstanding.
(d) Not annualized.
(e) Total investment return assumes dividend reinvestment.
</TABLE>

                                       
                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       37


<PAGE>



                              FINANCIAL STATEMENTS

John Hancock Funds - Institutional Series Trust -- Independence Balanced Fund

<TABLE>
Schedule of Investments
February 29, 1996

<CAPTION>
                                               NUMBER OF        MARKET
ISSUER, DESCRIPTION                             SHARES           VALUE
- -------------------                             ------           -----
<S>                                             <C>           <C>
COMMON STOCKS 
Aerospace (1.33%)
  Boeing Co.                                      200         $   16,225
  Raytheon Co.                                    400             20,050
  United Technologies Corp.                       300             32,250
                                                              ----------
                                                                  68,525
                                                              ----------
Automobile/Truck (1.60%)
  Chrysler Corp.                                  700             39,462
  Dana Corp.                                      400             12,100
  General Motors Corp.                            600             30,750
                                                              ----------
                                                                  82,312
                                                              ----------
Banks (3.21%)
  Banc One Corp.                                  110              3,918
  BankAmerica Corp.                               400             28,500
  Chemical Banking Corp.                          300             21,488
  Citicorp                                        100              7,800
  First Bank System, Inc.                         400             23,050
  First Chicago NBD Corp.                         200              8,675
  First Union Corp.                               300             18,150
  Fleet Financial Group, Inc.                     200              8,225
  J.P. Morgan & Co., Inc.                         200             16,375
  NationsBank Corp.                               400             29,500
                                                              ----------
                                                                 165,681
                                                              ----------
Beverages (1.60%)
  PepsiCo, Inc.                                 1,300             82,225
                                                              ----------
Building Products (0.92%)
  Home Depot, Inc. (The)                          700             30,275
  Lowe's Cos., Inc.                               300              9,300
  Masco Corp.                                     100              2,850
  Willamette Industries, Inc.                     100              5,250
                                                              ----------
                                                                  47,675
                                                              ----------
Chemicals (2.04%)
  Air Products & Chemicals, Inc.                  100              5,325
  Hercules, Inc.                                  800             48,000
  Monsanto Co.                                    300             40,386
  Morton International, Inc.                      300             11,363
                                                              ----------
                                                                 105,074
                                                              ----------
Computers (1.77%)
  Cisco Systems, Inc.*                            200              9,500
  Compaq Computer Corp.*                          100              5,063
  Digital Equipment Corp. *                       200             14,400
</TABLE>


The Schedule of Investments is a complete list of all securities owned by the
Independence Balanced Fund on February 29, 1996. It's divided into four main
categories: Common Stocks, Corporate Bonds, U.S. Government and Agencies
Securities and short-term investments. The investments are further broken down
by industry groups. Short-term investments, which represent the Fund's "cash"
position, are listed last.

<TABLE>

<CAPTION>

                                              NUMBER OF         MARKET
ISSUER, DESCRIPTION                             SHARES           VALUE
- -------------------                             ------           -----
<S>                                             <C>           <C>
Computers (continued)
  Hewlett-Packard Co.                             100         $   10,075
  Komag, Inc. *                                   400             12,550
  Microsoft Corp.*                                400             39,475
                                                              ----------
                                                                  91,063
                                                              ----------
Diversified Operations (2.19%)
  AlliedSignal, Inc.                              300             16,688
  Lockheed Martin Corp.                           400             30,500
  Ogden Corp.                                     100              2,136
  Tenneco, Inc.                                 1,000             55,875
  Textron, Inc.                                   100              7,875
                                                              ----------
                                                                 113,074
                                                              ----------
Drugs (3.32%)
  Abbott Laboratories                             900             37,575
  Bristol-Myers Squibb Co.                        800             68,100
  Merck & Co., Inc.                               900             59,625
  Schering-Plough Corp.                           100              5,613
                                                              ----------
                                                                 170,913
                                                              ----------
Electronics (2.26%)
  Applied Materials, Inc.*                        300             10,725
  General Electric Co.                            800             60,400
  Integrated Device Technology, Inc.*             400              4,800
  Lam Research Corp.*                             300             11,063
  Linear Technology Corp.                         300             13,950
  Tektronix, Inc.                                 100              4,538
  Teradyne, Inc. *                                300              6,113
  Texas Instruments, Inc.                         100              4,988
                                                              ----------
                                                                 116,577
                                                              ----------
Finance (1.65%)
  American Express Co.                          1,300             59,800
  Federal National Mortgage Assn                  800             25,300

                                                                  85,100
                                                              ----------
Foods (1.45%)
  Conagra, Inc.                                   100              4,213
  CPC International, Inc.                         100              6,925
  Heinz (H.J.) Co.                                500             17,000
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       38

<PAGE>



                              FINANCIAL STATEMENTS

John Hancock Funds - Institutional Series Trust -- Independence Balanced Fund

<TABLE>

<CAPTION>
                                              NUMBER OF            MARKET
ISSUER, DESCRIPTION                             SHARES              VALUE
- -------------------                             ------              -----
<S>                                             <C>               <C>
Foods (continued)
  Sara Lee Corp.                                   200            $    6,475
  Unilever N.V                                     300                40,350
                                                                  ----------
                                                                      74,963
                                                                  ----------
Healthcare (0.32%)
  Columbia/HCA Healthcare Corp.                    100                 5,475
  Vencor, Inc. *                                   300                11,213
                                                                  ----------
                                                                      16,688
                                                                  ----------
Insurance (2.97%)
  Aetna Life & Casualty Co.                        500                37,813
  Allstate Corp.                                   200                 8,575
  American International Group, Inc.               100                 9,663
  General Re Corp.                                 100                14,386
  Lincoln National Corp.                           800                44,000
  Marsh & McLennan Cos., Inc.                      400                38,850
                                                                  ----------
                                                                     153,287
                                                                  ----------
Machinery (0.17%)
  Dover Corp.                                      200                 8,900
                                                                  ----------
Medical/Dental (2.14%)
  Baxter International, Inc.                       600                27,450
  Johnson & Johnson                                700                65,450
  Medtronic, Inc.                                  300                17,213
                                                                  ----------
                                                                     110,113
                                                                  ----------
Metals (0.23%)
  Aluminum Co. of America                          100                 5,675
  Phelps Dodge Corp.                               100                 6,113
                                                                  ----------
                                                                      11,788
                                                                  ----------
Office Equipment & Supplies (1.89%)
  Pitney-Bowes, Inc.                               400                19,300
  Xerox Corp.                                      600                78,150
                                                                  ----------
                                                                      97,450
                                                                  ----------
Oil & Gas (5.53%)
  Amoco Corp.                                      800                55,600
  Baker Hughes, Inc.                               300                 7,913
  British Petroleum Co. PLC, American
    Depository Receipt ("ADR")
    (United Kingdom)                               100                10,036
  Exxon Corp.                                    1,000                79,500
  Halliburton Co.                                  400                21,950
  Mobil Corp.                                      500                54,813
  Panhandle Eastern Corp.                          700                20,038
  Phillips Petroleum Co.                         1,000                35,000
                                                                  ----------
                                                                     284,850
                                                                  ----------
Paper (0.59%)
  Kimberly-Clark Corp.                             400                30,550
                                                                  ----------
Photo Equipment (0.69%)
  Eastman Kodak Co.                                500            $   35,750
                                                                  ----------
Pollution Control (0.23%)
  Browning-Ferris Industries, Inc.                 400                11,850
                                                                  ----------
Retail (3.20%)
  Albertson's, Inc.                                200                 7,400
  Federated Department Stores, Inc. *              900                27,225
  Gap, Inc. (The)                                  100                 5,360
  McDonald's Corp.                                 600                30,000
  Premark International, Inc.100                 5,235
  Price/Costco, Inc.*                            1,100                18,975
  Ryans Family Steak Houses, Inc.*               1,200                 7,950
  Safeway, Inc.                                    400                11,950
  Toys "R" Us, Inc.                                700                16,713
  Wal-Mart Stores, Inc.                          1,600                34,000
                                                                  ----------
                                                                     164,808
                                                                  ----------
Rubber (0.46%)
  Goodyear Tire & Rubber Co.                       500                23,750
                                                                  ----------
Telecommunications (2.34%)
  A T & T Corp.                                  1,600               101,800
  MCI Communications Corp.                         200                 5,850
  Sprint Corp.                                     300                12,900
                                                                  ----------
                                                                     120,550
                                                                  ----------
Textiles (0.15%)
  Tommy Hilfiger Corp.* .                          200                 7,925
                                                                  ----------
Tobacco (1.35%)
  Philip Morris Cos., Inc.                         700                69,300
                                                                  ----------
Transportation (0.84%)
  Conrail, Inc.                                    300                21,638
  CSX Corp.                                        100                 4,488
  Delta Air Lines, Inc.                            100                 7,800
  Northwest Airlines Corp.*                        200                 9,175
                                                                  ----------
                                                                      43,101
                                                                  ----------
Utilities (2.96%)
  Entergy Corp.                                    900                25,538
  GTE Corp.                                      1,500                64,313
  Northern States Power Co.                        300                14,775
  Pacific Telesis Group .                        1,500                42,375
  SBC Communications, Inc.                         100                 5,488
                                                                  ----------
                                                                     152,489
                                                                  ----------
                            TOTAL COMMON STOCKS
                              (Cost $2,348,623) (49.40%)           2,546,331
                                                 -----            ----------
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       39

<PAGE>

                              FINANCIAL STATEMENTS

  John Hancock Funds - Institutional Series Trust -- Independence Balanced Fund

<TABLE>
<CAPTION>

                                   INTEREST    MATURITY       PAR VALUE         MARKET
ISSUER, DESCRIPTION                  RATE        DATE      (000'S OMITTED)       VALUE
- -------------------                  ----        ----      ---------------       -----
<S>                                <C>         <C>               <C>          <C>
CORPORATE BONDS
Diversified Operations (0.40%)
  Hanson Overseas                                                           
    PLC, Sr Note                    7.375%     01-15-03          $ 20         $   20,485                                        
                                                                              ----------

Utilities (0.20%)
  Hydro-Quebec Corp.,
    Deb Ser IF,
    (Gtd By Province
    of Quebec)                      7.375      02-01-03            10             10,400
                                                                              ----------
       TOTAL CORPORATE BONDS
            (Cost $31,930) (0.60%)                                                30,885
                            -----                                             ----------

U.S. GOVERNMENT AND AGENCIES SECURITIES
Governmental - U.S. (48.47%)
  United States
    Treasury Bond                  11.625      11-15-04           500            683,985
  United States
    Treasury Bond                   8.125      08-15-21           205            241,771
  United States
    Treasury Note                   7.375      11-15-97           110            113,403
  United States
    Treasury Note                   6.125      05-15-98           320            324,198
  United States
    Treasury Note                   7.125      09-30-99           110            115,053
  United States
    Treasury Note                   6.125      07-31-00           235            238,342
  United States
    Treasury Note                   6.125      09-30-00           160            162,426
  United States
    Treasury Note                   7.500      11-15-01           200            215,594
  United States
    Treasury Note                   7.500      02-15-05           370            403,822
                                                                              ----------
                                  TOTAL U.S. GOVERNMENT
                                AND AGENCIES SECURITIES   
                              (Cost $2,524,743) (48.47%)                       2,498,594
                                                  -----                       ----------
</TABLE>

<TABLE>
<CAPTION>

                                           INTEREST        PAR VALUE        MARKET  
ISSUER, DESCRIPTION                          RATE      (000'S OMITTED)       VALUE
- -------------------                          ----      ---------------      ------
<S>                                          <C>            <C>           <C>
SHORT-TERM INVESTMENTS 
Joint Repurchase Agreement (1.71%)
  Investment in a joint repurchase
  agreement transaction with
  BT Securities Corp., Dated
  02-29-96, due 03-01-96
  (secured by U.S. Treasury
  Bond, 12.50% due 08-15-14
  and by U. S. Treasury Notes,
  6.00% thru 8.25% due
  08-31-97 thru 07-15-98)
  - Note A                                   5.43%          $88           $   88,000
                                                                          ----------
Corporate Savings Account (0.00%)
  Investors Bank & Trust Company
    Daily Interest Savings Account
    Current Rate 4.75%                                                           444
                                                                          ----------
               TOTAL SHORT-TERM INVESTMENTS (1.71%)                           88,444
                                             ----                         ----------
                        TOTAL INVESTMENTS (100.18%)                       $5,164,254
                                           ======                         ==========

* Non-income producing security.

The percentage shown for each investment category is the total value of that category 
as a percentage of the net assets of the 
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       40


<PAGE>



                              FINANCIAL STATEMENTS

   John Hancock Funds - Institutional Series Trust -- Independence Growth Fund

<TABLE>
Schedule of Investments
February 29, 1996
- --------------------------------------------------------------------------------
<CAPTION>
                                                  NUMBER OF          MARKET
ISSUER, DESCRIPTION                                 SHARES            VALUE
- -------------------                                 ------            -----
<S>                                                   <C>           <C>
COMMON STOCKS 
Advertising (2.26%)
  Interpublic Group Of Companies, Inc.                100           $  4,213
  Omnicom Group, Inc.                                 200              8,175
                                                                    --------
                                                                      12,388
                                                                    --------
Aerospace (1.83%)
  Raytheon Co.                                        200             10,025
                                                                    --------
Automobile/Truck (1.04%)
  General Motors Corp. (Class E)                      100              5,713
                                                                    --------
Banks (2.39%)
  First Bank System, Inc.                             100              5,763
  NationsBank Corp.                                   100              7,375
                                                                    --------
                                                                      13,138
                                                                    --------
Beverages (4.60%)
  PepsiCo, Inc.                                       400             25,300
                                                                    --------
Building Products (5.32%)
  Home Depot, Inc. (The)                              400             17,300
  Lowe's Cos., Inc.                                   200              6,200
  Masco Corp.                                         200              5,700
                                                                    --------
                                                                      29,200
                                                                    --------
Chemicals (4.84%)
  Great Lakes Chemical Corp.                          100              7,150
  Hercules, Inc.                                      100              6,000
  Monsanto Co.                                        100             13,463
                                                                    --------
                                                                      26,613
                                                                    --------
Computers (6.78%)
  Cisco Systems, Inc.*                                200              9,500
  Compaq Computer Corp.*                              100              5,063
  Digital Equipment Corp.*                            100              7,200
  Mentor Graphics Corp. *                             200              2,850
  Oracle Systems Corp.*                               100              5,200
  Parametric Technology Corp.*                        100              7,433
                                                                    --------
                                                                      37,246
                                                                    --------
Cosmetics & Toiletries (1.46%)
  Avon Products, Inc.                                 100              8,038
                                                                    --------
Diversified Operations (2.03%)
  AlliedSignal, Inc.                                  100              5,563
  Tenneco, Inc.                                       100              5,588
                                                                    --------
                                                                      11,151
                                                                    --------
</TABLE>

The Schedule Of Investments is a complete list of all securities owned by the
Independence Growth Fund on February 29, 1996. It's divided into two main
categories: common stocks and short-term investments. Common stocks are further
broken down by industry groups. Short-term investments, which represent the
Funds's "cash" position, are listed last.

<TABLE>
<CAPTION>
                                                  NUMBER OF          MARKET
ISSUER, DESCRIPTION                                 SHARES            VALUE
- -------------------                                 ------            -----
<S>                                                   <C>           <C>
Drugs (11.04%)
  Abbott Laboratories                                 100           $  4,175
  Bristol-Myers Squibb Co.                            100              8,513
  Forest Laboratories, Inc.*                          200             10,400
  Lilly (Eli) and Co.                                 200             12,100
  Merck & Co., Inc.                                   300             19,870
  Schering-Plough Corp.                               100              5,613
                                                                    --------
                                                                      60,671
                                                                    --------
Electronics (10.68%)
  Analog Devices, Inc.*                               300              8,063
  Applied Materials, Inc.*                            200              7,150
  General Electric Co.                                200             15,100
  Integrated Device Technology, Inc.*                 200              2,400
  Intel Corp.                                         100              5,881
  Linear Technology Corp.                             100              4,650
  LSI Logic Corp.                                     100              2,763
  Millipore Corp.                                     100              4,438
  Teradyne, Inc. *                                    100              2,036
  Texas Instruments, Inc.                             100              4,988
  VLSI Technology, Inc.*                              100              1,200
                                                                    --------
                                                                      58,669
                                                                    --------
Finance (3.41%)
  American Express Co.                                200              9,200
  Dean Witter Discover & Co.                          100              5,375
  Equifax, Inc.                                       200              4,150
                                                                    --------
                                                                      18,725
                                                                    --------
Foods (2.63%)
  CPC International, Inc.                             100              6,925
  Kellogg Co.                                         100              7,550
                                                                    --------
                                                                      14,475
                                                                    --------
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       41



<PAGE>

                              FINANCIAL STATEMENTS

   John Hancock Funds - Institutional Series Trust -- Independence Growth Fund

<TABLE>
<CAPTION>
                                                 NUMBER OF           MARKET
ISSUER, DESCRIPTION                               SHARES             VALUE
- -------------------                               ------             -----
<S>                                                <C>              <C>
Hotels & Motels (0.89%)
  Marriott International, Inc.                     100              $  4,913
                                                                    --------
Insurance (2.55%)
  Allstate Corp.                                   100                 4,288
  Marsh & McLennan Cos., Inc.                      100                 9,713
                                                                    --------
                                                                      14,001
                                                                    -------- 
Machinery (1.62%)
  Dover Corp.                                      200                 8,900
                                                                    -------- 
Medical/Dental (6.33%)
  Baxter International, Inc.                       100                 4,575
  Johnson & Johnson                                200                18,700
  Medtronic, Inc.                                  200                11,475
                                                                    -------- 
                                                                      34,750
                                                                    -------- 
Office Equipment & Supplies (3.25%)
  Pitney-Bowes, Inc.                               100                 4,825
  Xerox Corp.                                      100                13,025
                                                                    --------
                                                                      17,850
                                                                    -------- 
Oil & Gas (0.99%)
  Anadarko Petroleum Corp.                         100                 5,450
                                                                    -------- 
Paper (1.39%)
  Kimberly-Clark Corp.                             100                 7,638
                                                                    -------- 
Photo Equipment (1.30%)
  Eastman Kodak Co.                                100                 7,150
                                                                    -------- 
Pollution Control (1.06%)
  Browning-Ferris Industries, Inc.                 100                 2,963
  WMX Technologies, Inc.                           100                 2,850
                                                                    -------- 
                                                                       5,813
                                                                    -------- 
Publishing (1.59%)
  McGraw-Hill Cos., Inc.                           100                 8,738
                                                                    -------- 
Retail (7.24%)
  Albertson's, Inc.                                200                 7,400
  Federated Department Stores, Inc. *              100                 3,025
  Outback Steakhouse, Inc.*                        100                 3,550
  Premark International, Inc.                      100                 5,238
  Staples, Inc. *                                  200                 5,175
  Toys "R" Us, Inc.*                               200                 4,775
  Wal-Mart Stores, Inc.                            500                10,625
                                                                    --------
                                                                      39,788
                                                                    --------
Steel (0.52%)
  British Steel PLC, (ADR)
  (United Kingdom)                                 100                 2,850
                                                                    -------- 
Telecommunications (3.38%)
  A T & T Corp.                                    200                12,725
  MCI Communications Corp.                         200                 5,850
                                                                    -------- 
                                                                      18,575
                                                                    -------- 
Tobacco (3.60%)                                                             
  Philip Morris Cos., Inc.                         200              $ 19,800
                                                                    -------- 
Transportation (1.42%)
  Delta Air Lines, Inc.                            100                 7,800
                                                                    --------
Utilities (1.72%)
  GTE Corp.                                        100                 4,288
  Nynex Corp.                                      100                 5,150
                                                                    -------- 
                                                                       9,438
                                                                    -------- 
                  TOTAL COMMON STOCKS
                      (Cost $500,016)           (99.16%)             544,806
                                                                    --------

<CAPTION>
                                           INTEREST     PAR VALUE
ISSUER, DESCRIPTION                          RATE    (000'S OMITTED)
- -------------------                          ----     -------------
<S>                                       <C>              <C>      <C>
SHORT-TERM INVESTMENTS
Joint Repurchase Agreement (0.91%)
  Investment in a joint repurchase
    agreement transaction with BT
    Securities Corp., Dated 02-29-96,
    due 03-01-96 (secured by U.S.
    Treasury Bond, 12.50% due
    08-15-14 and by U. S. Treasury
    Notes, 6.00% thru 8.25% due
    08-31-97 thru 07-15-98) -
    Note A                                  5.43%          $5          5,000
                                                                    --------
Corporate Savings Account (0.14%)
  Investors Bank & Trust Company
    Daily Interest Savings Account
    Current Rate 4.75%                                                   773
                                                                    --------
              TOTAL SHORT-TERM INVESTMENTS (1.05%)                     5,773
                                            ----                    --------
                       TOTAL INVESTMENTS (100.21%)                  $550,579
                                          ======                    ========

* Non-income producing security.
The percentage shown for each investment category is the total value of that
category as a percentage of the net assets of the Fund.

</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       42



<PAGE>


                              FINANCIAL STATEMENTS

   John Hancock Funds - Institutional Series Trust -- Independence Growth Fund

<TABLE>
Schedule of Investments 
February 29, 1996
- --------------------------------------------------------------------------------
<CAPTION>

                                              NUMBER OF             MARKET
ISSUER, DESCRIPTION                             SHARES               VALUE
- -------------------                             ------               -----

<S>                                              <C>              <C>
COMMON STOCKS 
Advertising (1.25%)
  Omnicom Group, Inc.                            1,200            $   49,050
                                                                  ----------
Aerospace (0.27%)
  United Technologies Corp.                        100                10,750
                                                                  ----------
Automobile/Truck (0.99%)
  Dana Corp.                                     1,100                33,275
  General Motors Corp.(Class H)                    100                 5,725
                                                                  ----------
                                                                      39,000
                                                                  ----------
Banks (8.80%)
  Bank Of Boston, Corp.                            600                29,175
  Bank Of New York                                 200                10,375
  Barnett Banks, Inc.                              400                25,000
  Chemical Banking Corp.                           400                28,650
  Comerica, Inc.                                   400                15,550
  Fifth Third Bancorp                              600                30,750
  First Bank System, Inc.                        1,000                57,625
  First Chicago NBD Corp.                        1,100                47,713
  Fleet Financial Group, Inc.                    1,000                41,120
  NationsBank Corp.                                300                22,120
  Northern Trust Corp.                             700                36,920
                                                                  ----------
                                                                     344,998
                                                                  ----------
Beverages (0.16%)
  PepsiCo, Inc.                                    100                 6,325
                                                                  ----------
Building Products (2.13%)
  Home Depot, Inc. (The)                           300                12,975
  Lowe's Cos., Inc.                                900                27,900
  Masco Corp.                                      900                25,650
  Rayonier, Inc.                                   500                17,125
                                                                  ----------
                                                                      83,650
                                                                  ----------
Chemicals (5.98%)
  Air Products & Chemicals, Inc.                   800                42,600
  Great Lakes Chemical Corp.                       500                35,750
  Hercules, Inc.                                 1,000                60,000
  Monsanto Co.                                     100                13,461
  Morton International, Inc.                       700                26,511
  Praxair, Inc.                                    800                27,600
  Sigma Aldrich Corp.                              500                28,625
                                                                  ----------
                                                                     234,547
                                                                  ----------
Computers (2.24%)
  Digital Equipment Corp. *                        500                36,000
  Komag, Inc. *                                    400                12,550

</TABLE>

The Schedule Of Investments is a complete list of all securities owned by the
Independence Medium Capitalization Fund on February 29, 1996. It's divided into
two main categories: common stocks and short-term investments. Common stocks are
further broken down by industry groups. Short-term investments, which represent
the Fund's "cash" position, are listed last.

<TABLE>
<CAPTION>

                                                NUMBER OF          MARKET
ISSUER, DESCRIPTION                              SHARES             VALUE
- -------------------                              ------             -----
<S>                                                <C>            <C>
Computers (continued)
  Mentor Graphics Corp. *                          400            $    5,700
  Novell, Inc.*                                    700                 8,531
  Parametric Technology Corp. *                    200                14,875
  Policy Management Systems Corp. *                200                10,225
                                                                  ----------
                                                                      87,881
                                                                  ----------
Cosmetics & Toiletries (1.15%)
  Avon Products, Inc.                              500                40,186
  Tambrands, Inc.                                  100                 4,825
                                                                  ----------
                                                                      45,011
                                                                  ----------
Diversified Operations (4.23%)
  AlliedSignal, Inc.                               100                 5,563
  Canadian Pacific, Ltd.                           700                13,825
  Corning, Inc.                                    300                 9,750
  Lockheed Martin Corp.                            300                22,875
  Ogden Corp.                                      700                14,963
  Tenneco, Inc.                                    600                33,525
  Textron, Inc.                                    600                47,250
  Tyco International Ltd.                          500                18,063
                                                                  ----------
                                                                     165,814
                                                                  ----------
Drugs (1.16%)
  Bristol-Myers Squibb Co.                         100                 8,513
  Forest Laboratories, Inc. *                      300                15,600
  Mylan Laboratories, Inc.                       1,100                21,450
                                                                  ----------
                                                                      45,563
                                                                  ----------
Electronics (5.04%)
  Analog Devices, Inc.* .                          550                14,781
  Applied Materials, Inc.*                         800                28,600
  General Signal Corp.                             600                21,825
  Integrated Device Technology, Inc.*              400                 4,800
  Lam Research Corp.*                              300                11,063
  Linear Technology Corp.                          600                27,900
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       43


<PAGE>

                              FINANCIAL STATEMENTS

               John Hancock Funds - Institutional Series Trust --
                    Independence Medium Capitalization Fund

<TABLE>
<CAPTION>

                                                           NUMBER OF     MARKET
ISSUER, DESCRIPTION                                         SHARES        VALUE
- -------------------                                         ------        -----
<S>                                                         <C>         <C>
Electronics (continued)
  LSI Logic Corp.                                             800     $   22,100
  Millipore Corp.                                             100          4,438
  National Semiconductor Corp.*                               900         14,063
  Parker-Hannifin Corp.                                       600         21,075
  Teradyne, Inc. *                                            600         12,225
  Texas Instruments, Inc.                                     300         14,963
                                                                      ----------
                                                                         197,833
                                                                      ----------
Energy (0.40%)
  Wheelabrator Technologies, Inc.                           1,000         15,875
                                                                      ----------
Finance (3.96%)
  Ahmanson (H.F.) & Co.                                     1,200         27,300
  American Express Co.                                        800         36,800
  Dean Witter Discover & Co.                                  500         26,875
  Golden West Financial Corp.                                 100          5,063
  Great Western Financial Corp.                               100          2,288
  MBNA Corp.                                                1,350         38,138
  Salomon, Inc.                                               500         19,063
                                                                      ----------
                                                                         155,527
                                                                      ----------
Foods (0.48%)
  Universal Foods Corp.                                       500         18,938
                                                                      ----------
Healthcare (1.94%)
  Health Management Associates,
    Inc. (Class A) *                                          150          4,706
  Tenet Healthcare Corporation                              1,200         26,850
  U.S. Health Care, Inc.                                      300         14,625
  Vencor, Inc. *                                              800         29,900
                                                                      ----------
                                                                          76,081
                                                                      ----------
Hotels & Motels (1.00%)
  Marriott International, Inc.                                800         39,300
                                                                      ----------
Insurance (10.49%)
  Aetna Life & Casualty Co.                                 1,200         90,750
  Allstate Corp.                                              100          4,288
  Aon Corp.                                                   500         26,000
  Cigna Corp.                                                 400         47,400
  Lincoln National Corp.                                    1,200         66,000
  Marsh & McLennan Cos., Inc.                               1,000         97,125
  Providian Corp.                                           1,100         50,875
  Safeco Corp.                                                800         29,000
                                                                      ----------
                                                                         411,438
                                                                      ----------
Leisure & Recreation (0.16%)
  Gaylord Entertainment Co. (Class A)                         100          2,675
  Harley-Davidson, Inc.                                       100          3,588
                                                                      ----------
                                                                           6,263
                                                                      ----------
Machinery (1.71%)
  Cooper Industries, Inc.                                     700     $   27,038
  Dover Corp.                                                 900         40,050
                                                                      ----------
                                                                          67,088
                                                                      ----------
Medical/Dental (2.86%)
  Baxter International, Inc.                                  100          4,575
  Becton Dickinson & Co.                                      500         41,000
  Guidant Corp.                                               700         33,163
  Medtronic, Inc.                                             200         11,475
  Pall Corp.                                                  800         21,800
                                                                      ----------
                                                                         112,013
                                                                      ----------
Metals (1.00%)
  Asarco, Inc.                                                100          2,988
  Newmont Mining Corp.                                        100          5,688
  Phelps Dodge Corp.                                          500         30,563
                                                                      ----------
                                                                          39,239
                                                                      ----------
Office Equipment & Supplies (2.93%)
  Pitney-Bowes, Inc.                                        1,300         62,725
  Xerox Corp.                                                 400         52,100
                                                                      ----------
                                                                         114,825
                                                                      ----------
Oil & Gas (7.31%)
  Anadarko Petroleum Corp.                                    200         10,900
  Baker Hughes, Inc.                                        1,300         34,288
  Dresser Industries, Inc.                                  1,100         30,938
  Halliburton Co.                                             900         49,388
  Kerr-McGee Corp.                                            500         29,813
  Mobil Corp.                                                 100         10,963
  Panhandle Eastern Corp.                                   1,400         40,075
  Phillips Petroleum Co.                                      700         24,500
  Sun Co., Inc.                                             1,100         32,038
  Texaco, Inc.                                                300         23,925
                                                                      ----------
                                                                         286,828
                                                                      ----------
Paper (1.63%)
  Champion International                                      500         20,000
  Kimberly-Clark Corp.                                        100          7,638
  Westvaco Corp.                                            1,250         36,250
                                                                      ----------
                                                                          63,888
                                                                      ----------
Pollution Control (0.93%)
  Allwaste                                                    200            875
  Browning-Ferris Industries, Inc.                          1,200         35,550
                                                                      ----------
                                                                          36,425
                                                                      ----------
Retail (9.06%)
  Albertson's, Inc.                                           300         11,100
  Cracker Barrel Old Country Store, Inc.                    1,000         21,000
  Federated Department Stores, Inc. *                       1,600         48,400

</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       44

<PAGE>

                              FINANCIAL STATEMENTS

               John Hancock Funds - Institutional Series Trust --
                    Independence Medium Capitalization Fund

<TABLE>
<CAPTION>

                                                 NUMBER OF      MARKET
ISSUER, DESCRIPTION                               SHARES         VALUE
- -------------------                               ------         -----
<S>                                                <C>        <C>
                                   
Retail (continued)
  Gap, Inc. (The)                                    700      $   37,538
  Kroger Co.                                         600          22,275
  Outback Steakhouse, Inc. *                         300          10,650
  Premark International, Inc.                        700          36,663
  Price/Costco, Inc.*                              1,800          31,050
  Ryans Family Steak Houses, Inc.*                 2,600          17,225
  Safeway, Inc.                                    1,200          35,850
  Super Valu Stores, Inc.                            100           3,225
  Sysco Corp.                                      1,100          36,163
  TJX Cos., Inc. (The)                               800          17,800
  Toys "R" Us, Inc.*                               1,100          26,263
                                                              ----------
                                                                 355,202
                                                              ----------
Rubber (1.21%)
  Goodyear Tire & Rubber Co.                       1,000          47,500
                                                              ----------
Steel (1.27%)
  AK Steel Holding Corp.                             300          10,838
  British Steel PLC, (ADR)
  (United Kingdom)                                   600          17,100
  Carpenter Technology                               600          21,750
                                                              ----------
                                                                  49,688
                                                              ----------
Telecommunications (0.44%)
  A T & T Corp.                                      200          12,725
  MCI Communications Corp.                           100           2,925
  Scientific-Atlanta, Inc.                           100           1,675
                                                              ----------
                                                                  17,325
                                                              ----------
Textiles (1.27%)
  Liz Claiborne, Inc.                                500          15,688
  Tommy Hilfiger Corp.* .                            400          15,850
  Warnaco Group, Inc. (Class A)                      700          18,200
                                                              ----------
                                                                  49,738
                                                              ----------
Tobacco (1.22%)
  Universal Corp.                                    200           5,375
  UST, Inc.                                        1,200          42,600
                                                              ----------
                                                                  47,975
                                                              ----------
Toys/Games/Hobby Products (0.08%)
  Mattel, Inc.                                       100           3,325
                                                              ----------
Transportation (4.09%)
  Conrail, Inc.                                      700          50,488
  CSX Corp.                                          500          22,438
  Delta Air Lines, Inc.                              300          23,400
  Northwest Airlines Corp. *                         400          18,350
  Trinity Industries, Inc.                           300          10,013
  UAL Corp.                                          200          35,725
                                                              ----------
                                                                 160,414
                                                              ----------
Utilities (9.01%)
  Baltimore Gas & Electric Co.                     1,700      $   48,238
  Central & South West Corp.                       1,200          33,300
  CMS Energy Corp.                                   100           3,038
  Consolidated Edison Of N.Y.                        700          22,838
  Consolidated Natural Gas Co.                     1,100          47,300
  Entergy Corp.                                    2,800          79,450
  GTE Corp.                                          200           8,575
  Houston Industries, Inc.                           400           9,050
  Idaho Power Co.                                    600          17,400
  LG&E Energy Corp.                                  100           4,300
  Northern States Power Co.                          700          34,475
  Peco Energy Co.                                    600          16,950
  Pinnacle West Capital Corp.                      1,000          28,375
                                                              ----------
                                                                 353,289
                                                              ----------
             TOTAL COMMON STOCKS
               (Cost $3,546,872) (97.85%)                      3,838,606
                                  -----                       ----------

<CAPTION>                                                     
                                        INTEREST    PAR VALUE
ISSUER, DESCRIPTION                       RATE   (000'S OMITTED)
- -------------------                       ----    -------------  
<S>                                       <C>         <C>     <C>
SHORT-TERM INVESTMENTS
Joint Repurchase Agreement (2.52%)
  Investment in a joint repurchase
    agreement transaction with BT
    Securities Corp., Dated 02-29-96,
    due 03-01-96 (secured by U.S.
    Treasury Bond, 12.50% due
    08-15-14 and by U. S. Treasury
    Notes, 6.00% thru 8.25% due
    08-31-97 thru 07-15-98) -
    Note A                                  5.43%     $99         99,000
                                                              ----------
Corporate Savings Account (0.01%)
  Investors Bank & Trust Company
    Daily Interest Savings Account
    Current Rate 4.75%.                                              404
                                                              ----------
              TOTAL SHORT-TERM INVESTMENTS (2.53%)                99,404
                                            ----              ----------
                       TOTAL INVESTMENTS (100.38%)            $3,938,010
                                          ======              ==========


* Non-income producing security.                                       
The percentage shown for each investment category is the total value of that
category as a percentage of the net assets of the Fund.
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       45


<PAGE>

                              FINANCIAL STATEMENTS

   John Hancock Funds - Institutional Series Trust -- Independence Value Fund

<TABLE>
Schedule of Investments
February 29, 1996
- --------------------------------------------------------------------------------
<CAPTION>

                                                 NUMBER OF     MARKET
ISSUER, DESCRIPTION                               SHARES        VALUE
- -------------------                               ------        -----
<S>                                                <C>        <C>
COMMON STOCKS 
Aerospace (4.24%)
  Boeing Co.                                       100        $  8,113
  Raytheon Co.                                     200          10,025
  United Technologies Corp.                        100          10,750
                                                              --------
                                                                28,888
                                                              --------
Automobile/Truck (5.81%)
  Chrysler Corp.                                   200          11,275
  Dana Corp.                                       200           6,050
  Eaton Corp.                                      100           5,788
  Ford Motor Co.                                   200           6,250
  General Motors Corp.                             200          10,250
                                                              --------
                                                                39,613
                                                              --------
Banks (18.50%)
  Bank of Boston, Corp.                            100           4,863
  BankAmerica Corp.                                200          14,250
  Chemical Banking Corp.                           300          21,486
  Citicorp                                         100           7,800
  First Bank System, Inc.                          200          11,525
  First Chicago NBD Corp.                          400          17,350
  First Union Corp.                                100           6,050
  Fleet Financial Group, Inc.                      300          12,336
  J.P. Morgan & Co., Inc.                          100           8,186
  Key Corp.                                        200           7,525
  NationsBank Corp.                                200          14,750
                                                              --------
                                                               126,121
                                                              --------
Building Products (0.84%)
  Masco Corp.                                      200           5,700
                                                              --------
Chemicals (3.41%)
  Hercules, Inc.                                   100           6,000
  Monsanto Co.                                     100          13,463
  Morton International, Inc.                       100           3,788
                                                              --------
                                                                23,251
                                                              --------
Computers (0.46%)
  Komag, Inc. *                                    100           3,138
                                                              --------
Containers (0.20%)
  Stone Container Corp.                            100           1,375
                                                              --------
Diversified Operations (5.14%)
  AlliedSignal, Inc.                               100           5,563
  Lockheed Martin Corp.                            100           7,625


</TABLE>

The Schedule of Investments is a complete list of all securities owned by the
Independence Value Fund on February 29, 1996. It's divided into two main
categories: common stocks and short-term investments. Common stocks are further
broken down by industry groups. Short-term investments, which represent the
Fund's "cash" position, are listed last.

<TABLE>
<CAPTION>       
                                                NUMBER OF      MARKET
ISSUER, DESCRIPTION                               SHARES        VALUE
- -------------------                               ------        -----
<S>                                                <C>        <C>
Diversified Operations (continued)
  Ogden Corp.                                      500        $ 10,688
  Tenneco, Inc.                                    200          11,175
                                                              --------
                                                                35,051
                                                              --------
Drugs (2.50%)
  Bristol-Myers Squibb Co.                         200          17,025
                                                              --------
Electronics (2.14%)
  Analog Devices, Inc.*                            150           4,031
  Applied Materials, Inc.*                         100           3,575
  Teradyne, Inc. *                                 100           2,038
  Texas Instruments, Inc.                          100           4,988
                                                              --------
                                                                14,632
                                                              --------
Finance (2.13%)
  Ahmanson (H.F.) & Co.                            200           4,550
  American Express Co.                             100           4,600
  Dean Witter Discover & Co.                       100           5,375
                                                              --------
                                                                14,525
                                                              --------
Insurance (7.77%)
  Aetna Life & Casualty Co.                        100           7,563
  Allstate Corp.                                   300          12,863
  Cigna Corp.                                      100          11,850
  Lincoln National Corp.                           200          11,000
  Marsh & McLennan Cos., Inc.                      100           9,713
                                                              --------
                                                                52,989
                                                              --------
Medical/Dental (0.67%)
  Baxter International, Inc.                       100           4,575
                                                              --------
Metals (1.77%)
  Asarco, Inc.                                     200           5,975
  Phelps Dodge Corp.                               100           6,113
                                                              --------
                                                                12,088
                                                              --------
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       46



<PAGE>


                             FINANCIAL STATEMENTS

   John Hancock Funds - Institutional Series Trust -- Independence Value Fund

<TABLE>
<CAPTION>

                                                NUMBER OF      MARKET
ISSUER, DESCRIPTION                              SHARES         VALUE
- -------------------                              ------         -----
<S>                                                <C>        <C>
Office Equipment & Supplies (2.62%)
  Pitney-Bowes, Inc.                               100        $  4,825
  Xerox Corp.                                      100          13,025
                                                              --------
                                                                17,850
                                                              --------
Oil & Gas (10.65%)
  Amoco Corp.                                      100           6,950
  Anadarko Petroleum Corp.                         100           5,450
  Chevron Corp.                                    100           5,563
  Exxon Corp.                                      300          23,850
  Halliburton Co.                                  100           5,488
  Mobil Corp.                                      100          10,963
  Panhandle Eastern Corp.                          100           2,863
  Phillips Petroleum Co.                           100           3,500
  Texaco, Inc.                                     100           7,975
                                                              --------
                                                                72,602
                                                              --------
Paper (1.12%)
  Kimberly-Clark Corp.                             100           7,638
                                                              --------
Retail (2.93%)
  Albertson's, Inc.                                200           7,400
  Federated Department Stores, Inc. *              100           3,025
  Price/Costco, Inc.*                              200           3,450
  Ryans Family Steak Houses, Inc.*                 200           1,325
  Toys "R" Us, Inc.*                               200           4,775
                                                              --------
                                                                19,975
                                                              --------
Rubber (0.70%)
  Goodyear Tire & Rubber Co.                       100           4,750
                                                              --------
Steel (1.67%)
  British Steel PLC, (ADR)
    (United Kingdom)                               400          11,400
                                                              --------
Telecommunications (1.56%)
  A T & T Corp.                                    100           6,363
  Sprint Corp.                                     100           4,300
                                                              --------
                                                                10,663
                                                              --------
Tobacco (1.97%)
  Philip Morris Cos., Inc.                         100           9,900
  UST, Inc.                                        100           3,550
                                                              --------
                                                                13,450
                                                              --------
Transportation (0.66%)
  CSX Corp.                                        100           4,488
                                                              --------
Utilities (19.72%)
  Baltimore Gas & Electric Co.                     600          17,025
  Bellsouth Corp.                                  200           7,975
  British Telecommunications PLC, (ADR)
    (United Kingdom)                               100           5,686
  Central & South West Corp.                       200           5,550
  Consolidated Natural Gas Co.                     100           4,300
  Entergy Corp.                                    400          11,350
  GTE Corp.                                        500          21,436
  Houston Industries, Inc.                         600          13,575
  LG&E Energy Corp.                                200           8,600
  Nynex Corp.                                      200          10,300
  Pacific Gas And Electric Co.                     300           7,686
  Pacific Telesis Group                            200           5,650
  Peco Energy Co.                                  400          11,300
  Texas Utilities                                  100           4,036
                                                              --------
                                                               134,469
                                                              --------
                  TOTAL COMMON STOCKS
                      (Cost $618,673) (99.18%)                 676,256
                                       -----                  --------

<CAPTION>

                                        INTEREST     PAR VALUE
ISSUER, DESCRIPTION                       RATE    (000'S OMITTED)
- -------------------                       ----     ------------- 
<S>                                       <C>          <C>    <C>      
SHORT-TERM INVESTMENTS
Joint Repurchase Agreement (1.47%)
  Investment in a joint repurchase
    agreement transaction with BT
    Securities Corp., Dated 02-29-96,
    due 03-01-96 (secured by U.S.
    Treasury Bond, 12.50% due 08-15-14
    and by U. S. Treasury Notes, 6.00%
    thru 8.25% due 08-31-97 thru
    07-15-98) - Note A.                     5.43%      $10      10,000
                                                              --------
Corporate Savings Account (0.46%)
  Investors Bank & Trust Company
    Daily Interest Savings Account
    Current Rate 4.75%.                                          3,192
                                                              --------
            TOTAL SHORT-TERM INVESTMENTS   (1.93%)              13,192
                                            ----              --------
                       TOTAL INVESTMENTS (101.11%)            $689,448
                                          ======              ========

* Non-income producing security.
The percentage shown for each investment category is the total value of that
category as a percentage of the net assets of the Fund.
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       47


<PAGE>


                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust --
                  Independence Diversified Core Equity Fund II

<TABLE>
Schedule of Investments 
February 29, 1996
- --------------------------------------------------------------------------------
<CAPTION>

                                                 NUMBER OF          MARKET
ISSUER, DESCRIPTION                                SHARES            VALUE
- -------------------                                ------            -----
<S>                                                <C>           <C>
COMMON STOCKS
Aerospace (2.77%)
  Boeing Co.                                       22,700        $  1,841,538
  Raytheon Co.                                     35,000           1,754,375
  United Technologies Corp.                        15,100           1,623,250
                                                                 ------------
                                                                    5,219,163
                                                                 ------------
Automobile/Truck (2.24%)
  Chrysler Corp.                                   27,800           1,567,225
  Dana Corp.                                       26,500             801,625
  Eaton Corp.                                      15,000             868,125
  General Motors Corp.                             19,200             984,000
                                                                 ------------
                                                                    4,220,975
                                                                 ------------
Banks (6.57%)
  BankAmerica Corp.                                19,700           1,403,625
  Barnett Banks, Inc.                               8,700             543,750
  Chemical Banking Corp.                           26,700           1,912,387
  First Bank System, Inc.                          33,200           1,913,150
  First Union Corp.                                37,000           2,238,500
  Fleet Financial Group, Inc.                      42,400           1,743,700
  NationsBank Corp.                                35,800           2,640,250
                                                                 ------------
                                                                   12,395,362
                                                                 ------------
Beverages (2.74%)
  Anheuser-Busch Cos., Inc.                         6,000             404,250
  Coca-Cola Co. (The)                              15,400           1,243,550
  PepsiCo, Inc.                                    55,800           3,529,350
                                                                 ------------
                                                                    5,177,150
                                                                 ------------
Building Products (2.72%)
  Home Depot, Inc. (The)                           93,300           4,035,225
  Lowe's Cos., Inc.                                35,300           1,094,300
                                                                 ------------
                                                                    5,129,525
                                                                 ------------
Chemicals (5.40%)
  Hercules, Inc.                                   67,200           4,032,000
  Monsanto Co.                                     24,400           3,284,850
  Morton International, Inc.                       75,900           2,874,712
                                                                 ------------
                                                                   10,191,562
                                                                 ------------
Computers (2.61%)
  Cisco Systems, Inc.* .                           14,000             665,000
  Digital Equipment Corp.*                         14,900           1,072,800
  Hewlett-Packard Co.                              12,700           1,279,525
  Komag, Inc.*                                     14,500             454,937

</TABLE>

The Schedule of Investments is a complete list of all securities owned by the
Independence Diversified Core Equity Fund II on February 29, 1996. It's divided
into two main categories: common stocks and short-term investments. Common
stocks are further broken down by industry groups. Short-term investments, which
represent the Fund's "cash" position, are listed last.

<TABLE>
<CAPTION>

                                                  NUMBER OF         MARKET
ISSUER, DESCRIPTION                                SHARES            VALUE
- -------------------                                ------            -----
<S>                                                <C>           <C>
Computers (continued)
  Mentor Graphics Corp.*                           20,000        $    285,000
  Microsoft Corp.*                                 11,800           1,164,512
                                                                 ------------
                                                                    4,921,774
                                                                 ------------
Cosmetics & Toiletries (0.21%)
  Avon Products, Inc.                               4,900             393,838
                                                                 ------------
Diversified Operations (5.04%)
  AlliedSignal, Inc.                               14,900             828,813
  Dial Corp.                                       45,200           1,356,000
  Lockheed Martin Corp.                            40,500           3,088,125
  Tenneco, Inc.                                    48,600           2,715,525
  Textron, Inc.                                     9,500             748,125
  Whitman Corp.                                    32,800             762,600
                                                                 ------------
                                                                    9,499,188
                                                                 ------------
Drugs (5.21%)
  Bristol-Myers Squibb Co.                         69,300           5,899,162
  Merck & Co., Inc.                                29,100           1,927,875
  Pfizer, Inc.                                     15,300           1,007,887
  Schering-Plough Corp.                            17,700             993,412
                                                                 ------------
                                                                    9,828,336
                                                                 ------------
Electronics (6.83%)
  Analog Devices, Inc.*                            35,500             954,063
  Applied Materials, Inc.*                         23,800             850,850
  General Electric Co.                             77,200           5,828,600
  Intel Corp.                                      28,000           1,646,750
  Lam Research Corp.*                              12,600             464,625
  Millipore Corp.                                  24,200           1,073,875
  Parker-Hannifin Corp.                                50               1,756
  Tektronix, Inc.                                  18,500             839,437

</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       48



<PAGE>

                             FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust --
                  Independence Diversified Core Equity Fund II

<TABLE>
<CAPTION>

                                                 NUMBER OF          MARKET
ISSUER, DESCRIPTION                                SHARES            VALUE
- -------------------                              ---------          ------
<S>                                                <C>            <C>

Electronics (continued)
  Teradyne, Inc.*                                  23,700        $    482,887
  Texas Instruments, Inc.                          15,000             748,125
                                                                 ------------
                                                                   12,890,968
                                                                 ------------
Finance (3.60%)
  American Express Co.                             89,600           4,121,600
  Dean Witter Discover & Co.                       32,300           1,736,125
  Equifax, Inc.                                     7,800             161,850
  Federal National Mortgage Assn                   24,500             774,812
                                                                 ------------
                                                                    6,794,387
                                                                 ------------
Foods (3.36%)
  CPC International, Inc.                          10,000             692,500
  General Mills, Inc.                              10,300             592,250
  Sara Lee Corp.                                   35,300           1,142,838
  Unilever N.V., (ADR) (Netherlands)               29,100           3,913,950
                                                                 ------------
                                                                    6,341,538
                                                                 ------------
Healthcare (0.93%)
  Columbia/HCA Healthcare Corp.                    19,200           1,051,200
  Health Management Associates, Inc. 
    (Class A)*                                     14,100             442,388
  Vencor, Inc.*                                     7,200             269,100
                                                                 ------------
                                                                    1,762,688
                                                                 ------------
Insurance (6.77%)
  Aetna Life & Casualty Co.                        46,800           3,539,250
  Allstate Corp.                                   70,610           3,027,404
  Cigna Corp.                                      12,200           1,445,700
  Lincoln National Corp.                           35,000           1,925,000
  Marsh & McLennan Cos., Inc.                      24,900           2,418,412
  Safeco Corp.                                     11,300             409,625
                                                                 ------------
                                                                   12,765,391
                                                                 ------------
Machinery (0.46%)
  Dover Corp.                                      19,400             863,300
                                                                 ------------
Medical/Dental (3.66%)
  Baxter International, Inc.                       47,600           2,177,700
  Johnson & Johnson                                35,400           3,309,900
  Medtronic, Inc.                                  24,800           1,422,900
                                                                 ------------
                                                                    6,910,500
                                                                 ------------
Metals (0.28%)
  Asarco, Inc.                                     10,400             310,700
  Phelps Dodge Corp.                                3,700             226,163
                                                                 ------------
                                                                      536,863
                                                                 ------------
Office Equipment & Supplies (2.66%)
  Xerox Corp.                                      38,500           5,014,625
                                                                 ------------

Oil & Gas (9.15%)
  Amoco Corp.                                      28,600        $  1,987,700
  Anadarko Petroleum Corp.                         35,500           1,934,750
  British Petroleum Co. PLC, (ADR)
    (United Kingdom)                                5,200             521,950
  Exxon Corp.                                      36,700           2,917,650
  Halliburton Co.                                  15,400             845,075
  Imperial Oil Ltd. (Canada)24,500                894,250
  Mobil Corp.                                      30,800           3,376,450
  Panhandle Eastern Corp.                          27,200             778,600
  Phillips Petroleum Co.                           69,800           2,443,000
  Texaco, Inc.                                     19,600           1,563,100
                                                                 ------------
                                                                   17,262,525
                                                                 ------------
Paper (2.28%)
  Kimberly-Clark Corp.                             39,200           2,993,900
  Mead Corp.                                       26,200           1,310,000
                                                                 ------------
                                                                    4,303,900
                                                                 ------------
Photo Equipment (1.56%)
  Eastman Kodak Co.                                41,200           2,945,800
                                                                 ------------
Pollution Control (0.33%)
  Browning-Ferris Industries, Inc.                 21,000             622,125
                                                                 ------------
Retail (5.04%)
  Albertson's, Inc.                                46,100           1,705,700
  Federated Department Stores, Inc.*               52,500           1,588,125
  McDonald's Corp.                                 14,700             735,000
  Price/Costco, Inc.*                              86,600           1,493,850
  Staples, Inc.*                                   26,700             690,863
  Toys "R" Us, Inc.*                               73,400           1,752,425
  Wal-Mart Stores, Inc.                            73,000           1,551,250
                                                                 ------------
                                                                    9,517,213
                                                                 ------------
Rubber (0.60%)
  Goodyear Tire & Rubber Co.                       23,800           1,130,500
                                                                 ------------
Soap & Cleaning Preparations (0.61%)
  Colgate-Palmolive Co.                            14,700           1,150,275
                                                                 ------------
Steel (0.53%)
  British Steel PLC, (ADR)
    (United Kingdom)                               35,300           1,006,050
                                                                 ------------
Telecommunications (4.98%)
  A T & T Corp.                                   113,500           7,221,438
  Pacific Telesis Group                            37,200           1,050,900
  Sprint Corp.                                     26,000           1,118,000
                                                                 ------------
                                                                    9,390,338
                                                                 ------------
Tobacco (2.60%)
  Philip Morris Cos., Inc.                         37,000           3,663,000
  UST, Inc.                                        34,700           1,231,850
                                                                 ------------
                                                                    4,894,850
                                                                 ------------
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       49


<PAGE>



                             FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust --
                  Independence Diversified Core Equity Fund II

<TABLE>
<CAPTION>

                                                  NUMBER OF          MARKET
ISSUER, DESCRIPTION                                 SHARES            VALUE
- -------------------                               ---------          ------
<S>                                                 <C>           <C>

Transportation (0.50%)
  Conrail, Inc.                                      4,100        $    295,713
  Delta Air Lines, Inc.                              8,400             655,200
                                                                  ------------
                                                                       950,913
                                                                  ------------
Utilities (6.35%)
  Consolidated Natural Gas Co.                      11,900             511,700
  Entergy Corp.                                     86,400           2,451,600
  GTE Corp.                                        141,600           6,071,100
  Pacific Gas & Electric Co.24,700                 632,938
  Peco Energy Co.                                   11,800             333,350
  Unicom Corp.                                      61,900           1,980,800
                                                                  ------------
                                                                    11,981,488
                                                                  ------------
                  TOTAL COMMON STOCKS
                  (Cost $163,762,530)               (98.59%)       186,013,110
                                                     -----        ------------

</TABLE>


<TABLE>
<CAPTION>

                                       INTEREST     PAR VALUE       MARKET
ISSUER, DESCRIPTION                      RATE    (000'S OMITTED)     VALUE
- -------------------                      ----    ---------------    ------
<S>                                     <C>         <C>          <C>
SHORT-TERM INVESTMENTS
Joint Repurchase Agreement (1.24%)
  Investment in a joint repurchase
    agreement transaction with BT
    Securities Corp., Dated 02-29-96,
    due 03-01-96 (secured by U.S.
    Treasury Bond, 12.50% due
    08-15-14 and by U. S. Treasury
    Notes, 6.00% thru 8.25% due
    08-31-97 thru 07-15-98) -
    Note A                              5.43%        $2,343      $  2,343,000
                                                                 ------------

Corporate Savings Account (0.00%)
  Investors Bank & Trust Company
    Daily Interest Savings Account 
    Current Rate 4.75%                                                    583
                                                                 ------------
         TOTAL SHORT-TERM INVESTMENTS  (1.24%)                      2,343,583
                                        ----                     ------------
                    TOTAL INVESTMENTS  (99.83%)                  $188,356,693
                                        =====                    ============

* Non-income producing security.

The percentage shown for each investment category is the total value of that
category as a percentage of the net assets of the Fund.
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       50


<PAGE>


                         NOTES TO FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

NOTE A -  
ACCOUNTING POLICIES 

John Hancock Independence Balanced Fund ("Independence Balanced Fund"), John
Hancock Independence Growth Fund ("Independence Growth Fund"), John Hancock
Independence Medium Capitalization Fund ("Independence Medium Capitalization
Fund"), John Hancock Independence Value Fund ("Independence Value Fund") and
John Hancock Independence Diversified Core Equity Fund II ("Independence
Diversified Core Equity Fund II"), (each, a "Fund" and collectively, the
"Funds"), are separate portfolios of John Hancock Institutional Series Trust
(the "Trust"), an open-end management investment company, registered under the
Investment Company Act of 1940. The Trust, organized as a Massachusetts business
trust in 1994, consists of twelve series portfolios: the Funds, John Hancock
Small Capitalization Equity Fund, John Hancock Multi-Sector Growth Fund, John
Hancock Active Bond Fund, John Hancock Dividend Performers Fund, John Hancock
Fundamental Value Fund, John Hancock Global Bond Fund and John Hancock
International Equity Fund. Prior to September 12, 1995, John Hancock
Multi-Sector Growth Fund was known as John Hancock Berkeley Sector Opportunity
Fund, John Hancock Active Bond Fund was known as John Hancock Berkeley Bond
Fund, John Hancock Dividend Performers Fund was known as John Hancock Berkeley
Dividend Performers Fund, John Hancock Fundamental Value Fund was known as John
Hancock Berkeley Fundamental Value Fund, John Hancock Global Bond Fund was known
as John Hancock Berkeley Global Bond Fund and John Hancock International Equity
Fund was known as John Hancock Berkeley Overseas Growth Fund. The investment
objective of Independence Balanced Fund and Independence Diversified Core Equity
Fund II is to seek above average total return consisting of capital appreciation
and income. The investment objective of Independence Growth Fund, Independence
Medium Capitalization Fund and Independence Value Fund is to seek above-average
total return. Each Fund currently has one class of shares with equal rights as
to voting, redempt ion, dividends and liquidation within their respective Fund.
The Trustees may authorize the creation of additional portfolios from time to
time to satisfy various investment objectives.

     Significant accounting policies of the Fund are as follows:

VALUATION OF INVESTMENTS Securities in the Funds' portfolios are valued on the
basis of market quotations, valuations provided by independent pricing services
or, at fair value as determined in good faith in accordance with procedures
approved by the Trustees. Short-term debt investments maturing within 60 days
are valued at amortized cost, which approximates market value. All portfolio
transactions initially expressed in terms of foreign currencies have been
translated into U.S. dollars as described in "Foreign Currency Translation"
below.

JOINT REPURCHASE AGREEMENT Pursuant to an exemptive order issued by the
Securities and Exchange Commission, the Funds, along with other registered
investment companies having a management contract with John Hancock Advisers,
Inc. (the "Adviser"), a wholly-owned subsidiary of The Berkeley Financial Group,
may participate in a joint repurchase agreement transaction. Aggregate cash
balances are invested in one or more repurchase agreements, whose underlying
securities are obligations of the U.S. government and/or its agencies. The
Funds' custodian bank receives delivery of the underlying securities for the
joint account on the Funds' behalf. The Adviser is responsible for ensuring that
the agreement is fully collateralized at all times.

INVESTMENT TRANSACTIONS Investment transactions are recorded as of the date of
purchase, sale or maturity. Net realized gains and losses on sales of
investments are determined on the identified cost basis. Capital gains realized
on some foreign securities are subject to foreign taxes and are accrued, as
applicable.

FEDERAL INCOME TAXES The Funds' policies are to comply with the requirements of
the Internal Revenue Code that are applicable to regulated investment companies
and to distribute all of their taxable income, including net realized gain on
investments, to their shareholders. Therefore, no federal income tax provisions
are required. Additionally, net capital losses of $4,647 attributable to



                                       51

<PAGE>

                         NOTES TO FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

security transactions occuring after October 31, 1995 from Independence Medium
Capitalization Fund are treated as arising on the first day (March 1, 1996) of
the Fund's current taxable year.

DIVIDENDS, DISTRIBUTIONS AND INTEREST Dividend income on investment securities
is recorded on the ex-dividend date or, in the case of some foreign securities,
on the date thereafter when the Funds are made aware of the dividend. Interest
income on investment securities is recorded on the accrual basis. Foreign income
may be subject to foreign withholding taxes which are accrued as applicable.

     The Funds record all dividends and distributions to shareholders from net
investment income and realized gains on the ex-dividend date. Such distributions
are determined in conformity with income tax regulations, which may differ from
generally accepted accounting principles.

EXPENSES The majority of the expenses of the Trust are directly identifiable to
an individual Fund. Expenses which are not readily identifiable to a specific
Fund will be allocated in such a manner as deemed equitable, taking into
consideration, among other things, the nature and type of expense and the
relative sizes of the Funds.

DEFERRED ORGANIZATION EXPENSE Expenses incurred in connection with the
organization of the Funds have been capitalized and are being charged to the
Funds' operations ratably over a five-year period that began with the
commencement of the investment operations of the Funds.

     In the event that any of the initial shares are redeemed during the
amortization period, the redemption proceeds will be reduced by a pro rata
portion of the then unamortized organization expense in the same proportion as
the number of the initial shares redeemed bears to the number of the initial
shares outstanding at the time of such redemption.

USE OF ESTIMATES The preparation of these financial statements in accordance
with generally accepted accounting principles incorporates estimates made by
management in determining the reported amount of assets, liabilities, revenues,
and expenses of the Funds.

FOREIGN CURRENCY TRANSLATION All assets and liabilities initially expressed in
terms of foreign currencies are translated into U.S. dollars based on London
currency exchange quotations as of 5:00 p.m., London time, on the date of any
determination of the net asset value of the Funds. Transactions affecting
statement of operations accounts and net realized gain/(loss) on investments are
translated at the rates prevailing at the dates of the transactions.

     The Funds do not isolate those portions of the results of operations
resulting from changes in foreign exchange rates on investments from the
fluctuations arising from changes in market prices of securities held. Such
fluctuations are included with the net realized and unrealized gain or loss from
investments.

     Reported net realized foreign exchange gains or losses arise from sales of
foreign currency, currency gains or losses realized between the trade and
settlement dates on securities transactions and the difference between the
amounts of dividends, interest, and foreign withholding taxes recorded on the
Funds' books and the U.S. dollar equivalent of the amounts actually received or
paid. Net unrealized foreign exchange gains or losses arise from changes in the
value of assets and liabilities other than investmen ts in securities at fiscal
year end, resulting from changes in the exchange rate.

NOTE B -
MANAGEMENT FEE, AND
TRANSACTIONS WITH AFFILIATES AND OTHERS

Under the present investment management contract, the Funds pay a monthly
management fee to the Adviser, for a continuous investment program equivalent,
on an annual basis as follows:

      FUND                                  RATE
      ----                                  ----
Independence           .70% of average daily net assets up to $500 million
 Balanced Fund         .65% of such assets in excess of $500 million

Independence           .80% of average daily net assets up to $500 million
 Growth Fund           .75% of such assets in excess of $500 million

Independence Medium    .80% of average daily net assets up to $500 million
Capitalization Fund    .75% of such assets in excess of $500 million

Independence           .80% of average daily net assets up to $500 million
 Value Fund            .75% of such assets in excess of $500 million

Independence           .50% of average daily net assets
 Diversified Core
 Equity Fund II



                                       52


<PAGE>

                         NOTES TO FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

     The Adviser is responsible for managing the Funds' investment business
affairs and overseeing the investment activities of the sub-adviser. The adviser
has a sub-investment management contract with Independence Investment
Associates, Inc. (the "Sub-Adviser"), under which the Sub-Adviser, subject to
the review of the Trustees and the overall supervision of the Adviser, provides
the Funds with investment services and advice with respect to investment
transactions. The Adviser pays the Sub-Adviser a portion of its advisory fee
quarterly from each Fund as follows:

Independence           60% of the advisory fee payable on the Fund's
 Balanced Fund         average daily net assets

Independence           55% of the advisory fee payable on the Fund's
 Growth Fund           average daily net assets

Independence           55% of the advisory fee payable on the Fund's
 Medium                average daily net assets
 Capitalization Fund

Independence           55% of the advisory fee payable on the Fund's
 Value Fund            average daily net assets

Independence           80% of the advisory fee payable on the Fund's
 Diversified           average daily net assets
 Core Equity Fund II

     Effective July 1, 1995, the Sub-Adviser has waived its fees until further
notice on Independence Balanced Fund, Independence Growth Fund, Independence
Medium Capitalization Fund and Independence Value Fund.

     In the event normal operating expenses of the Funds, exclusive of certain
expenses prescribed by state law, are in excess of the most restrictive state
limit where the Funds are registered to sell shares of beneficial interest, the
fees payable to the Adviser will be reduced to the extent of such excess, and
the Adviser will make additional arrangements necessary to eliminate any
remaining excess expenses. The current limits are 2.5% of the first $30,000,000
of the Fund's average daily net assets, 2.0% of the next $70,000,000 and 1.5% of
the remaining average daily net assets.

     The Adviser has agreed to limit Funds' expenses further to the extent
required to prevent expenses from exceeding: 0.90% of Independence Balanced
Fund's average daily net assets, 0.95% of Independence Growth Fund's average
daily net assets, 1.00% of Independence Medium Capitalization Fund's average
daily net assets, 0.95% of Independence Value Fund's average daily net assets
and 0.70% of Independence Diversified Core Equity Fund II's average daily net
assets. Accordingly, for the period ended February 29, 1996, the reduction in
the Funds' expenses collectively with any additional amounts not borne by the
Funds by virtue of the expense limit amounted to $79,593 for Independence
Balanced Fund, $80,343 for Independence Growth Fund, $75,379 for Independence
Medium Capitalization Fund, $76,993 for Independence Value Fund and $63,083 for
Independence Diversified Core Equity Fund II. The Adviser reserves the right to
terminate this limitation in the future.

     The Funds have a distribution agreement with John Hancock Funds, Inc. ("JH
Funds"), a wholly-owned subsidiary of the Adviser. For the period ended February
29, 1996, all sales of shares of beneficial interest were sold at net asset
value. The Funds pay all expenses of printing prospectuses and other sales
literature, all fees and expenses in connection with qualification as a dealer
in various states, and all other expenses in connection with the sale and
offering for sale of the shares of the Funds which have not been herein
specifically allocated to the Trust.

     The Funds have a transfer agent agreement with John Hancock Investor
Services Corporation ("Investor Services"), a wholly-owned subsidiary of The
Berkeley Financial Group. The Funds pay Investor Services a monthly transfer
agent fee equivalent, on an annual basis, to 0.05% of the Funds' average daily
net asset value, plus out-of-pocket expenses incurred by Investor Services on
behalf of the Funds for proxy mailings.

     On March 26, 1996, the Board of Trustees approved retroactively to January
1, 1996, an agreement, with the Adviser to perform necessary tax and financial
management services for the Funds.

     Edward J. Boudreau, Jr., Richard S. Scipione and Thomas W.L. Cameron are
directors and officers of the Adviser, and/or its affiliates as well as Trustees
of the Funds. The compensation of unaffiliated 



                                       53


<PAGE>


                         NOTES TO FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust


Trustees is borne by the Funds. Effective with the fees paid for 1995, the
unaffiliated Trustees may elect to defer for tax purposes their receipt of this
compensation under the John Hancock Group of Funds Deferred Compensation Plan.
The Funds make investments into other John Hancock funds, as applicable, to
cover their liabilities for the deferred compensation. Investments to cover the
Funds' deferred compensation liability are recorded on the Funds' books as an
other asset. The deferred compensation liability and the related other asset are
always equal and are marked to market on a periodic basis to reflect any income
earned by the investment as well as any unrealized gains or losses. The
investment has no impact on the operations of the Funds.

NOTE C -
INVESTMENT TRANSACTIONS

<TABLE>

Cost of purchases and proceeds from sales of securities, excluding short term
obligations, for the period ended February 29, 1996 were as follows:
<CAPTION>

                                      PURCHASES      PROCEEDS
                                      ---------      --------
<S>                                <C>            <C>
Independence Balanced Fund
  U.S. Government Securities       $  2,887,219   $   364,798
Other Investments                   3,756,846       394,395
Independence Growth Fund              605,829       108,514
Independence Medium                              
Capitalization Fund                 3,621,411        69,891
Independence Value Fund               682,756        67,228
Independence Diversified Core                      
  Equity Fund II                    208,169,010    45,905,183
</TABLE>


<TABLE>
     At February 29, 1996, the cost (excluding the corporate savings account)
and gross unrealized appreciation and depreciation in value of investments owned
by the Funds, as computed on a federal income tax basis, were as follows:

<CAPTION>   
                                                                              NET UNREALIZED
                         AGGREGATE  GROSS UNREALIZED     GROSS UNREALIZED      APPRECIATION/
                            COST      APPRECIATION         DEPRECIATION        DEPRECIATION
                         ---------  ----------------     ----------------     --------------
 <S>                  <C>             <C>                 <C>                 <C> 
Independence
  Balanced Fund       $  4,993,296    $   225,835         $   (55,321)        $   170,514
Independence
  Growth Fund              505,016         60,598             (15,808)             44,790
Independence
  Medium
  Capitalization
  Fund                   3,645,872        357,236             (65,502)            291,734
Independence
  Value Fund               628,673         63,772              (6,189)             57,583
Independence
  Diversified Core
  Equity Fund II       166,116,602     24,761,255          (2,521,747)         22,239,508
</TABLE>

NOTE D -
RECLASSIFICATION OF CAPITAL ACCOUNTS

During the year ended February 29, 1996, Independence Diversified Core Equity
Fund II has reclassified $832 from accumulated net realized gain on investments
and foreign currency transactions to undistributed net investment income. This
represents the cumulative adjustment necessary to report these balances on a tax
basis, excluding certain temporary differences, as of February 29, 1996.
Additional adjustments may be needed in subsequent reporting periods. These
reclassifications, which have no impact on the net asset value of the Fund, are
primarily attributable to certain differences in the computation of
distributable income and capital gains under federal tax rules versus generally
accepted accounting principles. The calculation of net investment income per
share in the financial highlights excludes these adjustments



                                       54


<PAGE>


                John Hancock Funds - Institutional Series Trust

REPORT OF INDEPENDENT PUBLIC ACCOUNTANTS 

To the Shareholders and Board of Trustees of John Hancock Institutional Series
Trust:

We have audited the accompanying statements of assets and liabilities of John
Hancock Institutional Series Trust (the Trust) comprising the Independence
Balanced Fund, Independence Growth Fund, Independence Medium Capitalization
Fund, Independence Value Fund, and Independence Diversified Core Equity Fund II,
including the schedules of investments, as of February 29, 1996, the related
statements of operations for the periods then ended, and the statements of
changes in net assets and the financial highlights for the periods presented.
These financial statements and financial highlights are the responsibility of
the Funds' management. Our responsibility is to express an opinion on these
financial statements and these financial highlights based on our audits.

     We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audits to obtain
reasonable assurance about whether the financial statements and financial
highlights are free of material misstatement. An audit includes examining, on a
test basis, evidence supporting the amounts and disclosures in the financial
statements. Our procedures included confirmation of securities owned as of
February 29, 1996 by correspondence with the custodian and brokers. An audit
also includes assessing the accounting principles used and significant estimates
made by management, as well as evaluating the overall financial statement
presentation. We believe that our audits provide a reasonable basis for our
opinion.

     In our opinion, the financial statements and financial highlights referred
to above present fairly, in all material respects, the financial position of
John Hancock Institutional Series Trust as of February 29, 1996, the results of
their operations for the periods then ended, the changes in their net assets and
the financial highlights for the periods presented, in conformity with generally
accepted accounting principles.

Arthur Andersen LLP
Boston, Massachusetts
April 5, 1996

TAX INFORMATION NOTICE (UNAUDITED)

For Federal Income Tax purposes, the following information is furnished with
respect to the distributions of the Funds during its fiscal year ended February
29, 1996.

     With respect to the Funds' ordinary taxable income for the fiscal year
ended February 29, 1996, shareholders will receive a 1996 U.S. Treasury
Department Form 1099-DIV in January of 1997. This will reflect the total of all
distributions which are taxable for the calendar year 1996.

     For the fiscal year ended February 29, 1996, 24.92% of the ordinary income
distributions from Independence Balanced Fund qualify for the corporate
dividends received deduction, 100% of the ordinary income distributions from
Independence Growth Fund qualify for the corporate dividends received deduction,
100% of the ordinary income distributions from Independence Medium
Capitalization Fund qualify for the corporate dividends received deduction,
83.67% of the ordinary income distributions from Independence Value Fund qualify
for the corporate dividends received deduction and 72.64% of the ordinary income
distributions from Independence Diversified Core Equity Fund II qualify for the
corporate dividends received deduction.


                                       55


<PAGE>

A 1/2" x 1/2" John Hancock Funds logo in upper left hand corner of the page. A
box sectioned in quadrants with a triangle in upper left, a circle in upper
right, a cube in lower left and a diamond in lower right. A tag line below
reads: "A Global Investment Management Firm."
                                                                 

                                                                       Bulk Rate
                                                                    U.S. Postage
                                                                            PAID
                                                                     Brocton, MA
                                                                  Permit No. 582









     This report is for the information of shareholders of the John Hancock
Institutional Series Trust. It may be used as sales literature when preceded or
accompanied by the current prospectus, which details charges, investment
objectives and operating policies.

A recycled logo in lower left hand corner with caption "Printed on Recycled
Paper."


<PAGE>
================================================================================
                               JOHN HANCOCK FUNDS
- --------------------------------------------------------------------------------





                           INSTITUTIONAL SERIES TRUST


                             DIVIDEND PERFORMERS FUND
                             ACTIVE BOND FUND
                             GLOBAL BOND FUND
                             MULTI-SECTOR GROWTH FUND
                             FUNDAMENTAL VALUE FUND
                             INTERNATIONAL EQUITY FUND


                                  ANNUAL REPORT



                                February 29, 1996


<PAGE>

<TABLE>

                               Table of Contents

               John Hancock Funds - Institutional Series Trust
<CAPTION>


                                                                            Page

<S>                                                                         <C>
1) Chairman's Message ...................................................     3

2) Portfolio Manager Commentary
    This commentary reflects the views of the portfolio manager or 
    portfolio management team through the end of the Fund's period 
    discussed in this report. Of course, the manager's or team's 
    views are subject to change as market and other conditions warrant.

    John Hancock Dividend Performers Fund ...............................     4

    John Hancock Active Bond Fund .......................................     8

    John Hancock Global Bond Fund .......................................    12

    John Hancock Multi-Sector Growth Fund ...............................    16

    John Hancock Fundamental Value Fund .................................    20

    John Hancock International Equity Fund ..............................    24

3) Financial Statements .................................................    28

4) Notes To Financial Statements ........................................    56
</TABLE>

<TABLE>
<CAPTION>
<S>                                     <C>                                            <C>
               TRUSTEES                            JAMES J. STOKOWSKI,                         SUB-INVESTMENT ADVISER
        EDWARD J. BOUDREAU, JR.                VICE PRESIDENT AND TREASURER                   Dividend Performers Fund
          THOMAS W.L. CAMERON                SUSAN S. NEWTON, VICE PRESIDENT,          SOVEREIGN ASSET MANAGEMENT CORPORATION
           JAMES F. CARLIN*             ASSISTANT SECRETARY AND COMPLIANCE OFFICER              1235 WESTLAKES DRIVE
        WILLIAM H. CUNNINGHAM*                JOHN A. MORIN, VICE PRESIDENT                       BERWYN, PA 19312
           CHARLES F. FRETZ*                                                                   Fundamental Value Fund
         HAROLD R. HISER, JR.*                          CUSTODIANS                          NM CAPITAL MANAGEMENT, INC.
          CHARLES L. LADNER*                         Global Bond Fund                     6501 AMERICAS PARKWAY, SUITE 950
         LEO E. LINBECK, JR.*                    International Equity Fund                   ALBUQUERQUE, NM 87110-5372
         PATRICIA P. MCCARTER*              STATE STREET BANK AND TRUST COMPANY              International Equity Fund
         STEVEN R. PRUCHANSKY*                      225 FRANKLIN STREET               JOHN HANCOCK ADVISERS INTERNATIONAL LTD
          RICHARD S. SCIPIONE                        BOSTON, MA 02110                             34 DOVER STREET
LT. GEN. NORMAN H. SMITH, USMC (RET.)*           Dividend Performers Fund                     LONDON, ENGLAND W1X 3RA
            JOHN P. TOOLAN*                          Active Bond Fund
     * Members of Audit Committee                Multi-Sector Growth Fund                      PRINCIPAL DISTRIBUTOR
                                                  Fundamental Value Fund                      JOHN HANCOCK FUNDS, INC.
               OFFICERS                       INVESTORS BANK & TRUST COMPANY                   101 HUNTINGTON AVENUE
       EDWARD J. BOUDREAU, JR.,                       89 SOUTH STREET                          BOSTON, MA 02199-7603
 Chairman and Chief Executive Officer                BOSTON, MA 02111
ROBERT G. FREEDMAN, VICE CHAIRMAN AND                                                              LEGAL COUNSEL
       CHIEF INVESTMENT OFFICER                       TRANSFER AGENT                               HALE AND DORR
      ANNE C. HODSDON, PRESIDENT        JOHN HANCOCK INVESTOR SERVICES CORPORATION                60 STATE STREET
           JAMES B. LITTLE,                            P.O.BOX 9277                               BOSTON, MA 02109
      SENIOR VICE PRESIDENT AND                    BOSTON, MA 02205-9277
       CHIEF FINANCIAL OFFICER                                                                INDEPENDENT ACCOUNTANTS
          THOMAS H. DROHAN,                         INVESTMENT ADVISER                         DELOITTE & TOUCHE LLP
 SENIOR VICE PRESIDENT AND SECRETARY            JOHN HANCOCK ADVISERS, INC.                      125 SUMMER STREET
                                                   101 HUNTINGTON AVENUE                       BOSTON, MA 02110-1617
                                                   BOSTON, MA 02199-7603

</TABLE>
                   
                     
                    

                                       2


<PAGE>

                               CHAIRMAN'S MESSAGE

DEAR FELLOW SHAREHOLDERS: 

     The stock market's record-breaking, whirlwind performance in 1995 will be a
tough act to follow in 1996. In fact, we've already seen greater market
volatility this year, particularly among last year's leaders N technology
stocks. That's to be expected after a year that saw market indexes soar,
including the Standard & Poor's 500-Stock Index's 37% advance. While many of the
same economic conditions that fostered the stellar 1995 market are still in
place N slow economic growth, muted inflation and decent corporate earnings N it
would be unrealistic to expect the market to stage a repeat in 1996. The old
saying "trees don't grow to the sky" comes to mind. Shareholders would do well
to temper expectations of investment returns and perhaps revisit their
investment allocations to determine if rebalancing their portfolio makes sense.

[PHOTO: A 1 1/4" photo of Edward J. Boudreau Jr., Chairman and Chief
Executive Officer, flush right, next to first paragraph.]
    
     No matter how you scale back your market expectations, you should always be
able to count on consistent customer service performance. At John Hancock Funds,
we never stop working to find ways to sustain and improve the quality of
information and assistance we provide you. Our commitment to this task is no
less than John Hancock's loyalty was to his fledgling country when he is said to
have uttered, "if it does the public good, burn Boston." We won't go that far,
of course, but we share our namesake's dedication to putting the public before
all else. 

     In our case, that public is you, our shareholders. We take very seriously
the role you have entrusted to us, that of helping you achieve your financial
goals. Part of that will always involve good customer service. So please do not
hesitate to call a Customer Service Representative at 1-800-755-4371 if you have
any questions or need information. We take pride in helping you with the same
spirit that John Hancock displayed at the dawning of America.



Sincerely,

/S/ Edward J. Boudreau, Jr.

EDWARD J. BOUDREAU, JR. CHAIRMAN AND CHIEF EXECUTIVE OFFICER


                                       3


<PAGE>

                    BY JOHN F. SNYDER III, PORTFOLIO MANAGER
                                  John Hancock
                            Dividend Performers Fund

[CALL OUT -- LEFT SIDE]
"...Some of our top performers during the period were our drug stocks..."

Historic Bull Market Marks Fund's First Year
- --------------------------------------------

John Hancock Dividend Performers Fund's first fiscal year was marked by an
historic bull market whose engine was falling interest rates, soaring corporate
earnings, tame inflation and slow economic growth. This combination drove the
Standard & Poor's 500-Stock Index -- the most common measure of the broad stock
market -- up 30.45% between March 30, 1995, when the Fund was launched, and
February 29, 1996, the Fund's fiscal year end. The Fund, too, prospered in this
environment and posted a total return of 22.79% at net asset value, for the same
period. That compared to the average growth and income fund's 25.76% total
return, according to Lipper Analytical Services.

     The difference in performance was due to the fact that we own almost no
technology stocks, while many of our peers have invested as much as 20% to 50%
of their portfolios in the sector. We believe the key to successful wealth
building lies in sticking to a time-tested investment discipline, no matter
which way the market's winds blow. It's not that we don't like technology
stocks; they simply don't meet our primary investment criterion. The Fund
focuses on high-quality, stable growth stocks that have a history of increasing
dividends every year for at least 10 years. Most technology stocks don't fit
that bill. In fact, some technology companies didn't even exist 10 years ago and
many don't pay dividends. So we're sticking to our tried and true investme nt
strategy. It's not too exciting, but we believe it's the best way to prese rve
and enhance wealth over time and outperform the broader market while maintaining
a prudent level of risk.


Winners And Losers

Some of our top performers during the period were our drug stocks, especially
Johnson &

[PHOTO: A 1 1/2" x 3 1/2" photo of the Dividend Performers management team,
bottom right. Caption reads: "John Snyder, Portfolio Manager, (seated center)
and members of the Dividend Performers Management Group."]


                                       4


<PAGE>

John Hancock Funds - Institutional Series Trust -- Dividend Performers Fund

[CALL OUT -- RIGHT SIDE]
"...We're still optimistic about the long-term prospects for stocks."

[CHART: Bar chart with heading "Fund Performance" at top left hand column.
Footnote below states "For the period March 30, 1995 through February 29, 1996."
The chart is scaled in increments of 10%, with 40% at the top and 0% at the
bottom. Within the chart, there are three solid bars. The first represents the
22.79% total return for John Hancock Dividend Performers Fund. The second
represents the 30.45% total return for the S&P 500-stock Index. The third
represents the 25.76% total return for the average growth and income fund. A
footnote below states: "The total return for John Hancock Dividend Performers
Fund is at net asset with all distributions reinvested. The average growth and
income fund is tracked by Lipper Analytical Services. The S&P 500-Stock Index is
an unmanaged index that includes 500 widely-traded common stocks. See following
page for historical performance information."]


Johnson and Merck & Co., which benefited from a slew of new drug approvals and
waning fears of government mandated health-care reform. Two other stars were
NationsBank and PepsiCo -- two of our largest holdings. NationsBank reaped the
rewards of falling interest rates, low inflation and strong loan growth.
PepsiCo's snack food and soft drink businesses have continued to grow rapidly,
especially overseas.

     Our retail stocks, however, were disappointing. Uncertainty about the
economy and high debt levels have kept consumers from spending money. Almost all
our retailers have felt the pinch, from Wal-Mart to Pep Boys, the auto parts
chain. We're holding onto the stocks nonetheless, because most of the bad news
is already priced into them and we're confident that the retailers we have
chosen can advance in a more competitive climate.

Investment Theme 

One consistent growth theme that has attracted our attention is the
consolidation of distribution companies in highly fragmented industries. In
their quest to cut costs, companies are reducing the number of vendors they use
in order to negotiate better prices and manage inventories more efficiently. In
response, we are seeing consolidation among distributors trying to grow big
enough to satisfy the full-service needs of these companies. The distributors we
prefer not only outperform their peers, but als o are increasing their market
share through acquisitions. A favorite is Alco Standard, the nation's leading
distributor of office supplies, primarily copiers. It still has only 8% market
share. However, it is rapidly acquiring smaller rivals. Another is Sysco Corp.,
the largest food service company in the country, which has only 10% market share
and an acquisition strategy that gives it lots of room to grow.

A Look Ahead

We're not likely to see stocks repeat their spectacular 1995 gains, but we're
still optimistic about the long-term prospects for stocks. The key will be to
maintain a stock-picking discipline even if we see a slowdown in earnings growth
in the broader market. The stable growth companies that we favor have the
potential to increase their earnings more than the projected earnings growth of
the market. After a wild 1995, investors may look with favor upon these stable
"dividend performers."

                                       5


<PAGE>


                             A LOOK AT PERFORMANCE


The table on the right shows the cumulative total return for the John Hancock
Dividend Performers Fund. Total return is a performance measure that equals the
sum of all income and capital gains dividends, assuming reinvestment of these
distributions, and the change in the price of the Fund's shares, expressed as a
percentage of the Fund's net asset value per share. Remember that all figures
represent past performance and are no guarantee of how the Fund will perform in
the future. Also, keep in mind that the total return and share price of the
Fund's investments will fluctuate. As a result, your Fund's shares may be worth
more or less than their original cost, depending on when you sell

<TABLE>

                            CUMULATIVE TOTAL RETURN

For the period ended December 31, 1995

                                                                   LIFE OF
                                                                     FUND
                                                                     ----
<S>                                                                 <C>   
John Hancock Dividend Performers Fund(1)                            18.31%



                              Notes to Performace

(1)  Commenced on March 30, 1995.

</TABLE>


                                       6


<PAGE>

                   WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Dividend Performers Fund would be worth on February 29, 1996, assuming you
invested on the day the Fund started and have reinvested all distributions. For
comparison, we've shown the same $250,000 investment in the Standard & Poor's
500 Stock Index -- an unmanaged index that includes 500 widely traded common
stocks and is often used as a measure of stock market performance.


[LINE CHART with the heading Dividend Performers Fund, representing the growth 
of a hypothetical $250,000 investment over the life of the fund. Within the 
chart are two lines.

The first line represents the value of the Standard & Poor's 500 Stock Index and
is equal to $327,024 as of February 29, 1996. The second line represents the 
value of the hypothetical $250,000 investment made in the Dividend Performers
Fund on March 30, 1995 and is equal to $306,972 as of February 29, 1996.]





                                       7


<PAGE>


                        BY JAMES K. HO, PORTFOLIO MANAGER

                                  John Hancock
                                Active Bond Fund

                   Attractive bond market conditions prevail
                   -----------------------------------------
                          during the Fund's first year
                          ----------------------------

[CALL OUT--LEFT SIDE]

"...we increased the Fund's exposure to corporate bonds..."

After a difficult 1994, the new year brought dramatic proof of just how swiftly
the investment climate can change for the better. By the time the Fund began
operating on March 30, 1995, the pace of economic growth had slowed enough that
many bond market investors expected the Federal Reserve would soon sever its
string of seven straight interest-rate increases and begin cutting rates again.
Those expectations were fulfilled in July 1995, when the Fed trimmed one-quarter
percentage point off the rate banks charge each other for overnight loans, known
as the federal funds rate. Two more quarter-point cuts followed, in December
1995 and January 1996. The cuts took place against a backdrop of moderating
inflation and slowing growth. As investors reached for yield in a declining-rate
environment, corporate bonds, with their higher yields than comparable
government securities, were prime beneficiaries.

     During its first fiscal year, John Hancock Active Bond Fund focused on
building strategic positions. One consequence of that was an unusually high cash
position during the period as we selectively added holdings to the portfolio.
Cash as a percentage of the Fund's total assets was 22% at the end of February;
normally, we would expect it to be around 5%. While having a large cash position
caused performance to lag overall in 1995, it helped protect the Fund in
February when interest rates rose and bond prices fell on reports that suggested
the economy

[PHOTO: A 2 1/2" x 3 1/2" photo of the Active Bond Management Group. Caption
reads: "The Active Bond Management Group (l-r): Ben Matthews; James Ho,
Portfolio Manager; Seth Robbins"]

                                       8


<PAGE>

     John Hancock Funds - Institutional Series Trust -- Active Bond Fund

[CALL OUT--RIGHT SIDE]

"...the outlook for bonds has become more uncertain in 1996."


[CHART: Bar chart with the heading "Fund Performance" at top of left hand
column. A footnote below states "For the period March 30, 1995 through February
29, 1996." The chart is scaled in increments of 5%, with 15% at the top and 0%
at the bottom. Within the chart, there are three solid bars. The first
represents the 7.76% total return for John Hancock Active Bond Fund. The second
represents the 11.86% total return for the Lehman Government/Corporate Index.
The third represents the 10.90% total return for the average corporate debt
A-rated fund. A footnote below states: "The total return for John Hancock Active
Bond Fund is at net asset with all distributions reinvested. The average
corporate debt A-rated fund is tracked by Lipper Analytical Services. The Lehman
Brothers Government/Corporate Bond Index is a broad index composed of
investment-grade corporate and government bonds. See following page for
historical performance information.]


might be heating up. The Fund's total return from its inception on March 30,
1995 through February 29, 1996 was 7.76% at net asset value, compared to 10.90%
for the average corporate debt A-rated fund, according to Lipper Analytical
Services. The Lehman Government/Corporate Index's return was 11.86% for the
same period.

Sector and strategy review

During the period, we continued to increase the Fund's stake in corporate bonds
and by the end of February, they totaled about 35% of the Fund's net assets.
Another 42% was in U.S. Government securities. In the current climate, our goal
is to increase the corporate sector to about 70% of the Fund. Utilities, at 18%
of net assets, were the largest corporate sector in the Fund. Electric utilities
were top performers during the past year, despite serious questions about the
long-term health of the industry as it prepares for deregulation. Accordingly,
we focused on higher-yielding utility bonds, issued by improving companies that
were among the first to confront the challenges of a more competitive future.
Examples include Long Island Lighting Company and Midland Funding Corp., a
co-generation venture with Consumer Power.

     As economic growth slowed, we de-emphasized our stake in the bonds of
cyclical industries. One exception is Weirton Steel, which makes tin containers
for food and is therefore less susceptible to downturns in the economy than more
traditional steel manufacturers. Also, as media companies benefited from
industry consolidation and the long-awaited passage of the Telecommunications
Act, the Fund profited from investments in Time Warner, Turner Broadcasting
Systems and Century Communications, a cable-service provider.

Outlook

The outlook for bonds has become more uncertain in 1996. Shortly after the
Fund's fiscal year ended, interest rates on the bellwether 30-year Treasury Bond
rose as a spate of mixed economic data prompted fears that increased economic
growth might keep the Fed from further lowering interest rates. It remains to be
seen whether rates will keep increasing. In this environment, the Fund should
hold up well relative to its peers because of its shorter duration. Duration is
a measure of how much the Fund's share price fluctuates in response to interest
rate moves. The shorter the duration, the less the price moves with changes in
rates.

                                       9


<PAGE>

                            A LOOK AT PERFORMANCE

The table on the right shows the cumulative total return for the John Hancock
Active Bond Fund. Total return is a performance measure that equals the sum of
all income and capital gains dividends, assuming reinvestment of these
distributions, and the change in the price of the Fund's shares, expressed as a
percentage of the Fund's net asset value per share. Remember that all figures
represent past performance and are no guarantee of how the Fund will perform in
the future. Also, keep in mind that the total return and share price of the
Fund's investments will fluctuate. As a result, your Fund's shares may be worth
more or less than their original cost, depending on when you sell them.

<TABLE>
                            CUMULATIVE TOTAL RETURN

For the period ended December 31, 1995
<CAPTION>
                                                                    LIFE OF
                                                                      FUND
                                                                      ----
<S>                                                                   <C>  
John Hancock Active Bond Fund(1)                                      8.78%


                                     YIELD
As of February 29, 1996
<CAPTION>
                                                                   SEC 30-DAY
                                                                      YIELD
                                                                      -----
John Hancock Active Bond Fund                                         6.21%


                              Notes to Performance
(1) Commenced on March 30, 1995.

</TABLE>


                                       10


<PAGE>


                   WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Active Bond Fund would be worth on February 29, 1996, assuming you invested on
the day the Fund started and have reinvested all distributions. For comparison,
we've shown the same $250,000 investment in the Lehman Government/Corporate Bond
Index -- an unmanaged index that measures the performance of U.S. government
bonds, U.S. corporate bonds, and Yankee bonds.

[CHART: Line Chart with the heading Active Bond Fund, representing the growth 
of a hypothetical $250,000 investment over the life of the fund. Within the 
chart are two lines.

The first line represents the value of the Lehman Government/Corporate Bond
Index and is equal to $279,662 as of February 29, 1996. The second line
represents the value of the hypothetical $250,000 investment made in the Active
Bond Fund on March 30, 1995 and is euqal to $269,393 as of February 29, 1996.]





                                       11


<PAGE>

                 BY LAWRENCE J. DALY, ANTHONY A. GOODCHILD AND
                      JANET L. CLAY, CO-PORTFOLIO MANAGERS

                                  John Hancock
                                Global Bond Fund

                    Attractive environment for global bonds;
                    ---------------------------------------
                           Europe lags United States
                           -------------------------

[CALL OUT--LEFT SIDE]

"During its first year of operation, the Fund remained in a building stage..."

John Hancock Global Bond Fund began operating in April 1995, at a time when
interest rates were peaking around the world and bond prices were bottoming out.
Later in the year, as U.S. economic growth slowed, the Federal Reserve lowered
interest rates three times, shaving a total of three-quarters of a percentage
point off the federal funds rate, the rate banks charge each other for overnight
loans. Stable to declining wages -- due mainly to competitive pressures from
developing economies in Asia and Latin America -- convinced many global bond
market investors that inflation was unlikely to be a problem anytime soon.
Meanwhile, the dollar rebounded versus most global currencies, offsetting losses
earlier in the year. Together those factors made for an attractive environment
for global bond investors, despite some volatility during the final weeks of the
Fund's fiscal year.

     During its first year of operation, the Fund remained in a building stage
and lacked sufficient assets to take full advantage of favorable market
conditions. In some cases, the Fund faced minimum investment requirements it
could not meet, forcing it to pass up some attractive opportunities. As a
result, cash levels were unusually high for most of the period and overall
performance lagged somewhat. The Fund's total return from its starting date on
April 19, 1995 through February 29, 1996 was 4.37%, at net asset value. During
the same period, the JP Morgan Global Government Index returned 4.27%. By
comparison, the average general world income fund returned 9.26%, according to
Lipper Analytical Services. As the Fund has grown, we've begun implementing a
strategy we believe will yield competitive results in the months and years to
come. 

[PHOTO: A 2" x 3" photo of Anthony A. Goodchild, Janet Clay, Lawrence J. Daly,
bottom right. Caption reads: "Anthony A. Goodchild, Janet Clay, Lawrence J.
Daly."]


                                       12


<PAGE>

      John Hancock Funds - Institutional Series Trust -- Global Bond Fund

[CALL OUT--RIGHT SIDE]

"The outlook for the global bond market remains favorable despite its recent
setbacks."

[CHART: Bar Chart with the heading "Fund Performance at top of left hand
column. A footnote below states: "For the period April 19, 1995 through February
29, 1996." The chart is scaled in increments of 2%, with 10% at the top and 0%
at the bottom. Within the chart, there are three solid bars. The first
represents the 4.37% total return for John Hancock Global Bond Fund. The second
represents the 9.26% total return for the average general world income fund. The
third represents the 4.27% total return for the JP Morgan Global Government
Index. A footnote below states: "The total return for John Hancock Global Bond
Fund is at net asset with all distributions reinvested. The average general
world income fund is tracked by Lipper Analytical Services. The JP Morgan Global
Government Index is a broad-based index composed of government bonds issued in
13 countries in Europe, Asia and North America. See following page for
historical performance information.]


Strategy recap 

The Fund distributes its assets among a number of attractive countries in an
effort to diversify the portfolio's risk. In determining country allocations, we
look for evidence of political stability, sound fiscal policies, a stable
currency and high relative value compared to other countries. At the end of the
fiscal year, the Fund's assets were invested in government bonds as follows:
about 45% in Europe, mainly Germany, France, Italy and the United Kingdom; about
34% in U.S. government bonds; about 7% in Canada, Australia and New Zealand.
Another 12% of the Fund's assets remained in cash equivalents. In Europe, our
largest concentration was a 17% stake in Germany, where interest rates have
remained stubbornly high despite low inflation and would therefore appear to
have room to fall. Notable for its absence in the Fund during the year was
Japan, where rates are so low and the economic picture so uncertain that we've
chosen not to get involved, other than through a 15.4% direct currency stake in
the yen. Elsewhere around the world, the Fund's currency positions roughly
paralleled global weightings with a slight bias toward the U.S. dollar. The Fund
also maintained a neutral stance on duration, an indicator of how much the
Fund's share price will vary in response to changing interest rates. With a
duration of just over five years, we essentially avoided betting on a move in
interest rates in either direction.

Outlook

The outlook for the global bond market remains favorable despite its recent
setbacks. We believe the world's developed economies are in the midst of a
long-term deflationary cycle brought on by increased competition from emerging
markets in Latin America and the Pacific Rim. This is very positive over the
long term. Real rates of return, which take into account inflation, remain
artificially high, especially in Europe. This should inhibit growth in the
coming months and eventually force down rates as central banks attempt to
stimulate economic activity. Given the lackluster economic climate in Europe,
rates would appear to have little room to rise much above current levels. In the
months ahead, we'll be watching closely for progress on a balanced budget
agreement in Washington. If the United States can show leadership by reducing
spending and cutting the deficit, others may follow, significantly improving the
outlook for global bond markets.


- --------------------------------------------------------------------------------
International investing involves special risks, such as currency and political
risks and differences in accounting standards and financial reporting.


                                       13


<PAGE>


                             A LOOK AT PERFORMANCE

The table on the right shows the cumulative total return for the John Hancock
Global Bond Fund. Total return is a performance measure that equals the sum of
all income and capital gains dividends, assuming reinvestment of these
distributions, and the change in the price of the Fund's shares, expressed as a
percentage of the Fund's net asset value per share. Remember that all figures
represent past performance and are no guarantee of how the Fund will perform in
the future. Also, keep in mind that the total return and share price of the
Fund's investments will fluctuate. As a result, your Fund's shares may be worth
more or less than their original cost, depending on when you sell them.

<TABLE>
                            CUMULATIVE TOTAL RETURN

For the period ended December 31, 1995

                                                                    LIFE OF
                                                                     FUND
                                                                     ----
<S>                                                     <C>          <C>   
John Hancock Global Bond Fund(1)                                     6.96% 


                                     YIELD
As of February 29, 1996
<CAPTION>
                                                                   SEC 30-DAY
                                                                     YIELD
                                                                     -----
  John Hancock Global Bond Fund                                      5.90%


                              Notes to Performance
(1) Commenced on April 19, 1995.

</TABLE>


                                       14


<PAGE>

                   WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Global Bond Fund would be worth on February 29, 1996, assuming you invested on
the day the Fund started and have reinvested all distributions. For comparison,
we've shown the same $250,000 investment in the J. P. Morgan Global Government
Index -- an unmanaged market capitalization-weighted index consisting of the
government bond markets of Australia, Belgium, Canada, Denmark, France, Germany,
Italy, Japan, Netherlands, Spain, Sweden, the United Kingdom and the United
States. All issues have a remaining maturity of at least one year and are
rebalanced monthly.

[CHART: Line Chart with the heading Global Bond Fund, representing the growth 
of a hypothetical $250,000 investment over the life of the fund. Within the 
chart are two lines.

The first lines represents the value of the J.P.Morgan Global Government Index
and is equal to $266,886 as of February 29, 1996. The second line represents 
the value of the hypothetical $250,000 investment made in the Global Bond Fund
on April 19, 1995 and is equal to $260,912 as of February 29, 1996.]




 

                                       15


<PAGE>

                      BY KEVIN R. BAKER, PORTFOLIO MANAGER

                                  John Hancock
                            Multi-Sector Growth Fund

                   Technology, health-care and energy stocks
                   -----------------------------------------
                          boost Fund in its first year
                          ----------------------------

[CALL OUT--LEFT SIDE]

"...throughout the year, the Fund maintained its holdings within the same five 
sectors..."

Kevin R. Baker, previously a member of John Hancock Multi-Sector Growth Fund's
management group, is now carrying out the day-to-day investment decisions for
the Fund. A second vice president of John Hancock Funds, Mr. Baker also manages
John Hancock Global Resources Fund and John Hancock Special Opportunities Fund.

Declining interest rates, low inflation, slow economic growth and steady
corporate earnings helped propel the stock market to record highs in 1995. The
trend continued in the first two months of 1996, despite an increase in market
volatility. In this positive environment, the Fund produced strong results for
its first fiscal year. From its opening on April 11, 1995 through February 29,
1996, the Fund had a total return of 25.98% at net asset value. For the same
period, the Standard & Poor's 500-Stock Index gained 29.49%. For another
comparison, the average capital appreciation fund returned 27.02% according to
Lipper Analytical Services.

Strategy & performance

Throughout the year, the Fund maintained its holdings within the same five
sectors of the economy that we identified at the outset as having the best
growth potential. They are energy, precious metals, technology, healthcare and
media and information distribution companies.

     Investing in energy stocks, which became the Fund's largest category by the
period's end at 31% of net assets, is a way to capitalize on exploding growth in
the world's developing markets, which have a huge unmet demand for energy.
Demand is also being fueled in the U.S. by the popularity of gas-guzzling
vehicles, increased speed limits and more driving. At the same time, worldwide
supply remains unchanged. Chesapeake Energy, whose advanced drilling techniques
paid off with new finds, was one of the Fund's best performers.

[PHOTO: A 2 " x 3" photo of Kevin R. Baker and James Boyd. Caption reads: "Kevin
R. Baker, Portfolio Manager (right) and Multi-Sector Growth group member James
Boyd."]


                                       16


<PAGE>

John Hancock Funds - Institutional Series Trust -- Multi-Sector Growth Fund

[CALL OUT--RIGHT SIDE]

"...the outlook remains positive for growth stocks..."

[CHART: Bar chart with the heading "Fund Performance" at the top of left
hand column. A footnote below states: "For the period April 11, 1995 through
February 29, 1996." The chart is scaled in increments of 10%, with 30% at the
top and 0% at the bottom. Within the chart, there are three solid bars. The
first represents the 25.98% total return for John Hancock Multi-Sector Growth
Fund. The second represents the 29.49% total return for the S&P 500-stock Index.
The third represents the 27.02% total return for the Average capital
appreciation fund. A footnote below states: "The total return for John Hancock
Multi-Sector Growth Fund is at net asset with all distributions reinvested. The
average capital appreciation fund is tracked by Lipper Analytical Services. The
S&P 500-Stock Index is an unmanaged index that includes 500 widely-traded common
stocks. See following page for historical performance information.]

As oil companies search for new resources, deep-water drilling companies such as
Diamond Offshore Drilling and Reading & Bates have profited. The same positive
supply and demand fundamentals exist in the precious metals sector. That caused
us to up our stake in this group to 14% of the Fund's net assets at the end of
the period. Two strong performers were Newmont Gold and Kinross Gold.

     After leading in the early part of the year, technology finished the period
as the Fund's second smallest category, with 9% of the Fund's net assets. The
shift out of technology occurred because we took profits on some popular
Internet stocks. These included Netscape and Uunet, bo th of which we sold for
three times what their prices were at the end of the period. We still like the
Internet stocks, but we'll wait until prices come down more before we go back
in. Several other tech winners during the period were Sun Microsystems, whose
software and hardware are being applied toward the Internet, and network company
Cascade Communications, which we sold during the period.

     Health-care stocks, which accounted for 26% of the Fund's net assets at the
end of the period, performed well as the industry's focus on cost containment
continues. Boston Scientific, a medical device manufacturer with a broad array
of products, was a stellar performer which we sold during the period. Others
were Healthsource, one of our largest holdings, and pharmaceutical giant Johnson
& Johnson.

     The media and information distribution sector dropped from 22% of the
Fund's net assets on August 31, 1995 to 2% by February 29, 1996 primarily
because we took profits on America Online and sold our broadcasting stocks. The
broadcasters' prices already reflected the expected increase in 1996 ad revenues
from the Olympics and presidential election. In addition, spot advertising
appeared weak. We're watching this category for signs of deterioration in future
earnings growth which would cause us to re-evaluate the group.

Outlook

It's unrealistic to expect 1996 to stage a repeat of last year's record-breaking
performance and we believe the broad stock market could revert to its more
historical level of 8% to 10% returns. Nonetheless, the outlook remains positive
for growth stocks, as long as the economy grows slowly and interest rates stay
low or decline further. With careful stock selection, the growth companies we
target are often better able to deliver higher-than-average earnings than the 
more economically sensitive cyclical companies.

                                       17


<PAGE>

                             A LOOK AT PERFORMANCE

The table on the right shows the cumulative total return for the John Hancock
Multi-Sector Growth Fund. Total return is a performance measure that equals the
sum of all income and capital gains dividends, assuming reinvestment of these
distributions, and the change in the price of the Fund's shares, expressed as a
percentage of the Fund's net asset value per share. Remember that all figures
represent past performance and are no guarantee of how the Fund will perform in
the future. Also, keep in mind that the total return and share price of the
Fund's investments will fluctuate. As a result, your Fund's shares may be worth
more or less than their original cost, depending on when you sell them. 

<TABLE>
                            CUMULATIVE TOTAL RETURN

For the period ended December 31, 1995
<CAPTION>

                                                                    LIFE OF
                                                                      FUND
                                                                      ----
<S>                                                                  <C>    
John Hancock Multi-Sector Growth Fund(1)                             20.79% 





                              Notes to Performance

(1) Commenced on April 11, 1995.

</TABLE>

                                       18


<PAGE>

                    WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Multi-Sector Growth Fund would be worth on February 29, 1996, assuming you
invested on the day the Fund started and have reinvested all distributions. For
comparison, we've shown the same $250,000 investment in the Standard & Poor's
500 Stock Index -- an unmanaged index that includes 500 widely traded common
stocks and is often used as a measure of stock market performance.

[CHART: Line chart with the heading Multi-Sector Growth Fund, representing the 
growth of a hypothetical $250,000 investment over the life of the fund. Within 
the chart are two lines.

The first line represents the value of the Standard & Poor's 500 Stock Index
and is equal to $327,024 as of February 29, 1996. The second line represents 
the value of the hypothetical $250,000 investment made in the Multi-Sector 
Growth Fund on April 11, 1995 and is equal to $314,941 as of February 29, 1996.]





                                       19


<PAGE>


           BY ANGELA BRISTOW, CFA, FOR THE PORTFOLIO MANAGEMENT TEAM

                                  John Hancock
                             Fundamental Value Fund

                  Fund maintains value discipline in the face
                  -------------------------------------------
                           of a booming stock market
                           -------------------------

[CALL OUT--LEFT SIDE]

"The Fund's value stratege is driven towards buying assets...of undervalued 
companies."

John Hancock Fundamental Value Fund began on April 19, 1995, as the stock market
was starting what was to be one of its strongest years on record. During this
time, the Fund concentrated on building positions in stocks that demonstrate
outstanding potential for above-average capital appreciation over the long-term.
From April 19, 1995 through February 29, 1996, the Fund posted a total return of
8.61% at net asset value. During the same period, the Standard & Poor's
500-Stock Index returned 29.62%. By comparison, the average growth and income
fund posted total returns of 23.09% according to Lipper Analytical Services.

     The Fund's value strategy is driven toward buying assets, specifically of
undervalued companies, those that are fundamentally sound with earnings growth
potential, but whose stocks are mispriced. Because of our asset value
orientation, we are less focused on near-term earnings momentum. This
longer-term perspective means we will very often be "out of step" with the
broader market, as we were during this period. While some short-term results may
be disappointing, we believe that those who understand our strategy and have the
ability to invest for the long term will share with us in the full potential of
our approach.

Top performers

One of the Fund's strongest performers in 1995 was Dole Foods. When it was added
to the Fund, it was out of favor and selling at a low price relative to both
asset value and earnings power. Since then, Dole has benefited from a
combination of a cyclical recovery in banana prices and 

[PHOTO: A 2 1/2" x 3 1/2" photo of The Fundamental Value portfolio management
team, bottom right. Caption reads: "The Fundamental Value Portfolio Management
Team: Charles Womack (left), Thomas Christopher (middle), Angela Bristow
(right)."]


                                       20


<PAGE>

   John Hancock Funds - Institutional Series Trust -- Fundamental Value Fund

[CALL OUT--RIGHT SIDE]

"The universe of stocks from which the Fund selects its holdings is more
undervalued today...than at any time in the last 10 years."

[CHART: Bar chart with heading "Fund Performance" at top left hand column.
Footnote below states "For the period April 19, 1995 through February 29, 1996."
The chart is scaled in increments of 10%, with 30% at the top and 0% at the
bottom. Within the chart, there are three solid bars. The first represents the
8.61% total return for John Hancock Fundamental Value Fund. The second
represents the 29.62% total return for the S&P 500-stock Index. The third
represents the 23.09% total return for the average growth and income fund. A
footnote below states: "The total return for John Hancock Fundamental Value Fund
is at net asset with all distributions reinvested. The average growth and income
fund is tracked by Lipper Analytical Services. The S&P 500-Stock Index is an
unmanaged index that includes 500 widely-traded common stocks. See following
page for historical performance information."]

its internal restructuring moves. These combined to recapture investors'
attention and the stock rose by more than 50%. We saw similar results from our
holdings in Ross Stores, Times Mirror and Boeing.

Three additions share common traits

Among the several interesting additions to the Fund was ANTEC, a leading
provider of the basic components needed to build the network systems that the
telecommunications industry will need with deregulation. It's also a "back door"
play on the growth potential of the Internet. Another was Cooper Cameron, a
market leader in deep-water, subsea oil and gas well completion technology which
has been overlooked by the market. With an outstanding management program of
internal restructuring, the company shows the potential to provide surprisingly
strong earnings recovery and price appreciation as the world's major oil
companies seek to add to productive reserves in heretofore undeveloped offshore
areas. A third holding was Horsham. Astutely managed, this company's shares sell
at a 30% discount to net asset value and near the value of the company's
holdings in gold and cash alone. That means investors are getting the rest of
the company's assets, primarily extensive holdings in North American commercial
real estate and gasoline refining and marketing, essentially "for free."

     While these companies are from different industries and appear quite
different, from our perspective they are really quite similar. Each has a strong
margin of safety, selling at or near conservative estimates of private market or
asset value. Each management has a solid track record and is highly motivated to
increase the stock price. Finally, each operates in an industry that gives it
room to grow earnings and stock prices above current levels. For these reasons,
we believe each of these new stocks can add materially to the Fund's future
returns.

     Looking ahead, we expect the perennial forces of competitive capitalism to
prevail, which could allow the asset values in our investments to be fully
realized. The universe of stocks from which the Fund selects its holdings is
more undervalued today, based on a comparison of median price to book value,
than at any time in the last 10 years. This bodes well for our strategy in
general and sustains our resolve to proceed as always, seeking the hidden
opportunities and overlooked asset values which have the potential to provide
above-average returns over time.



                                       21


<PAGE>

                             A LOOK AT PERFORMANCE

The table on the right shows the cumulative total return for the John Hancock
Fundamental Value Fund. Total return is a performance measure that equals the
sum of all income and capital gains dividends, assuming reinvestment of these
distributions, and the change in the price of the Fund's shares, expressed as a
percentage of the Fund's net asset value per share. Remember that all figures
represent past performance and are no guarantee of how the Fund will perform in
the future. Also, keep in mind that the total return and share price of the
Fund's investments will fluctuate. As a result, your Fund's shares may be worth
more or less than their original cost, depending on when you sell them.

<TABLE>
                            CUMULATIVE TOTAL RETURN

For the period ended December 31, 1995
<CAPTION>

                                                                   LIFE OF
                                                                     FUND
                                                                     ----
<S>                                                                  <C>   
John Hancock Fundamental Value Fund(1)                               6.10% 


                              Notes to Performance

(1) Commenced on April 19, 1995.

</TABLE>

                                       22


<PAGE>

                    WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment in the John Hancock
Fundamental Value Fund would be worth on February 29, 1996, assuming you
invested on the day the Fund started and have reinvested all distributions. For
comparison, we've shown the same $250,000 investment in the Standard & Poor's
500 Stock Index -- an unmanaged index that includes 500 widely traded common
stocks and is often used as a measure of stock market performance.

[CHART: Line chart with the heading Fundamental Value Fund, representing the 
growth of a hypothetical $250,000 investment over the life of the fund. Within 
the chart are two lines.

The first line represents the value of the Lehman Brothers Government/Corporate
Bond Index and is equal to $327,024 as of February 29, 1996. The second line
represents the value of the hypothetical $250,000 investment made in the 
Fundamental Value Fund on April 19, 1995 and is equal to $271,534 as of 
February 29, 1996.]







                                       23



<PAGE>
        BY DAVID S. BECKWITH AND JOHN L.F. WILLS, CO-PORTFOLIO MANAGERS

                                  John Hancock
                           International Equity Fund

[CALL OUT--LEFT SIDE]

"...Japanese stocks totaled about 28% of the Fund's assets."

                    Foreign Stocks Lag Surging U.S. market;
            faster growth, strong earnings help asia outpace europe

John Hancock International Equity Fund began operating on March 30, 1995. As is
often the case with new funds that are accumulating assets, cash as a percentage
of the Fund's total investments was high earlier in the period, and that held
performance back in the Fund's first fiscal year relative to its peer group.
From March 30, 1995 through February 29, 1996, the Fund's total return was 9.81%
at net asset value, compared to 15.41% for the average international fund,
according to Lipper Analytical Services. By comparison, the FT Actuaries World
Ex-US Index returned 10.38% for the same period.

    As time went on and we were able to put more of the Fund's assets to work,
we began to see results we hope will be more indicative of the Fund's long-term
performance. In fact, through the first two months of 1996, the Fund had
outperformed its peers. Clearly, this is a short-term barometer, but it's
encouraging. What follows is a regional breakdown of the Fund's key investments.

Japan

The Japanese economy has shown signs lately of emerging from a long and
difficult recession. Industrial production is picking up, buoyed in part by the
long-delayed rebuilding effort following the Kobe earthquake. Throughout the
Japanese economy, we see the potential for significant earnings gains. Large
holdings include cyclicals, such as Daido Steel and Fanuc, an industrial
robotics manufacturer. As consumer confidence has grown, we've moved into
consumer products manufacturers such as Matsushita Electric and Sony; and Jusco,
a retailer. By the end of the period, Japanese stocks totaled 28% of the Fund's
assets.

Hong Kong

Banks have been the performance drivers lately in Hong Kong, boosted by lower
interest rates around the world and a thriving local real estate market. The
Fund has investments in Wharf Holdings, a real estate developer; HSBC Holdings,
a bank; and CITIC Pacific, Swire Pacific and Hutchison Whampoa, broad-based
conglomerates that give the Fund exposure to China. Over the past six months,
Hong Kong has been the hottest market in Asia, with stocks up an average 

[PHOTO: A 1 3/4" x 1 1/2" photo of David S. Beckwith, bottom center. Caption
reads: "David S. Beckwith, Co-Portfolio Manager."]

                                      24

<PAGE>
  John Hancock Funds - Institutional Series Trust -- International Equity Fund

[CALL OUT--RIGHT SIDE]

"There are signs that the rest of the world may be catching up to the U.S. 
market."

[CHART: Bar chart with heading "Fund Performance" at top left hand column.
Footnote below states "For the period March 30, 1995 through February 29, 1996."
The chart is scaled in increments of 5%, with 20% at the top and 0% at the
bottom. Within the chart, there are three solid bars. The first represents the
9.81% total return for John Hancock International Equity Fund. The second
represents the 10.38% total return for the FT Actuaries World Ex-US Index. The
third represents the 15.41% total return for the average international fund. A
footnote below states: "The total return for John Hancock International Equity
Fund is at net asset with all distributions reinvested. The average
international fund is tracked by Lipper Analytical Services. The FT Actuaries
World Ex-US Index is a broad-based index composed of approximately 1800
securities in 23 countries. See following page for historical performance
information.]

of around 20%. Hong Kong represents about 15% of the Fund's total assets.
Elsewhere in Southeast Asia, the Fund has investments in Singapore, where our
largest holding is Keppel, a conglomerate with interests in shipping, banking
and property development; and Malaysia, where we own Resorts World, a casino and
resort operator.

[PHOTO: A 1 3/4" x 1 1/2" photo of John L.F. Wills at bottom left. Caption
reads: "John L.F. Wills, Co-Portfolio Manager."]

Europe

In Europe, we focused on France, Britain and Germany, and to a lesser extent on
Scandinavia. As a whole, Europe was overshadowed last year by surging stock
prices in the United States, despite stronger economic growth and solid
earnings. Overall, stock prices there are more attractive than they are in the
U.S. right now. In France, our largest holding is Carrefour, a global retailer
expanding aggressively into Latin America and other emerging markets. In
Britain, we especially like Dixons Group, an electronics retailer; and Thorn
EMI, an entertainment company whose music holdings have become takeover targets.
In Germany, we own just two stocks: Bayer, the pharmaceutical and chemical
company; and Mannesmann, a giant industrial conglomerate with holdings in
cellular communications, engineering and automotive applications.

Australia/New Zealand

Our focus in this part of the world is on natural-resource stocks, such as
Broken Hill Proprietary and Carter Holt Harvey, a New Zealand wood products
company. We also hold a position in Telecom Corp. of New Zealand, a well-run
communications company with a growing cellular operation.

Outlook

While foreign markets have lagged the U.S. stock market since 1993, there are
signs that the rest of the world may be catching up to the U.S. market. Even
while stock prices have stalled overseas, economic expansion and earnings growth
have continued unabated, often at a faster rate than in the United States. As a
result, traditional measures of value such as price-to-earnings ratio have grown
steadily more attractive, and represent a significant long-term opportunity.

- --------------------------------------------------------------------------------

International investing involves special risks, such as currency and political 
risks and differences in accounting standards and financial reporting.



                                       25


<PAGE>
                             A LOOK AT PERFORMANCE

The table on the right shows the cumulative total return for the John Hancock
International Equity Fund. Total return is a performance measure that equals the
sum of all income and capital gains dividends, assuming reinvestment of these
distributions, and the change in the price of the Fund's shares, expressed as a
percentage of the Fund's net asset value per share. Remember that all figures
represent past performance and are no guarantee of how the Fund will perform in
the future. Also, keep in mind that the total return and share price of the
Fund's investments will fluctuate. As a result, your Fund's shares may be worth
more or less than their original cost, depending on when you sell them.


<TABLE>
                             CUMULATIVE TOTAL RETURN

For the period ended December 31, 1995
<CAPTION>
                                                                    LIFE OF
                                                                     FUND
                                                                     ----
<S>                                                                   <C>  
John Hancock International Equity Fund(1)                             6.60%


                              Notes to Performance

(1) Commenced on March 30, 1995

</TABLE>

                                      26


<PAGE>
                   WHAT HAPPENED TO A $250,000 INVESTMENT...

The chart on the right shows how much a $250,000 investment
in the John Hancock International Equity Fund would be worth on February 29,
1996, assuming you invested on the day the Fund started and have reinvested all
distributions. For comparison, we've shown the same $250,000 investment in the
Financial Times-Actuaries World EX-US Index -- an unmanaged index composed of
securities in 23 countries, excluding the United States. Selection criteria,
overseen by the World Index Policy Committee, exclude all companies that cannot
be purchased by foreigners. Companies then are ranked by market capitalization,
and the top 5% are automatically included. 

[CHART: Line chart with the heading International Equity Fund, representing the
growth of a hypothetical $250,000 investment over the life of the fund.  Within
the chart are two lines.

The first line represents the value of the hypothetical $250,000 investment made
in the International Equity Fund on March 30, 1995 and is equal to $274,520 as
of February 29, 1996. The second line represents the value of the Financial
time-Actuaries World Index and is equal to $263,263 as of February 29, 1996.]


                                       27

<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust
<TABLE>

Statements of Assets and Liabilities
February 29, 1996
- ---------------------------------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                              DIVIDEND       ACTIVE        GLOBAL
                                                                                             PERFORMERS       BOND          BOND
                                                                                                FUND          FUND          FUND
                                                                                             ----------      ------        ------

<S>                                                                                          <C>           <C>           <C>       
Assets:
  Investments at value - Note C:
    Common and preferred stocks (cost - $2,510,160, none and none, respectively)             $2,975,969    $       --    $     --
    Bonds (cost - none, $887,319 and $186,537, respectively)                                         --       896,710     186,522
    Options (premium paid - none, none and $288, respectively)                                       --            --         128
    Short-term investments (cost - $351,000, $260,000 and $26,000, respectively)                351,000       260,000      26,000
    Corporate savings account                                                                     3,387         2,202          --
                                                                                             ----------    ----------    --------
                                                                                              3,330,356     1,158,912     212,650
  Cash                                                                                               --            --          47
  Receivable for closed forward foreign currency exchange contracts - Note A                         --            --         916
  Receivable for open forward foreign currency exchange contracts sold - Note A                      --            --          67
  Receivable for shares sold                                                                         13            --          -- 
  Interest receivable                                                                                56        17,714       4,344
  Dividends receivable                                                                            7,756            --          --
  Foreign tax receivable                                                                             --            --         143
  Deferred organization expenses - Note A                                                         6,765         6,705       6,674
                                                                                             ----------    ----------    --------
               Total Assets                                                                   3,344,946     1,183,331     224,841
               ------------------------------------------------------------------------------------------------------------------
Liabilities:                                                                                                              
  Payable for open forward foreign currency exchange contracts purchased - Note A                    --            --         318
  Dividend payable                                                                                   --           226          47
  Payable to John Hancock Advisers, Inc. and affiliates - Note B                                 25,726        12,478       7,735
                                                                                             ----------    ----------    --------
               Total Liabilities                                                                 25,726        12,704       8,100
               ------------------------------------------------------------------------------------------------------------------
Net Assets:                                                                                                               
  Capital paid-in                                                                             2,826,605     1,159,566     217,473
  Accumulated net realized gain on investments and foreign currency transactions                 22,146         1,670         332
  Net unrealized appreciation (depreciation) of investments and foreign currency                                          
    transactions                                                                                465,809         9,391        (448)
  Undistributed net investment income (distributions in excess of net investment income)          4,660            --        (616)
                                                                                             ----------    ----------    --------
               Net Assets                                                                    $3,319,220    $1,170,627    $216,741
               ==================================================================================================================
Net Asset Value Per Share                                                                                                 
  (based on 326,898, 135,437 and 25,613 shares, respectively, of beneficial interest                                      
  outstanding - unlimited number of shares authorized with no par value)                     $    10.15    $     8.64    $   8.46
  ===============================================================================================================================
</TABLE>

The Statement of Assets and Liabilities is each Fund's balance sheet and shows
the value of what the Fund owns, is due and owes as of February 29, 1996. You'll
also find the net asset value per share as of that date.

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       28


<PAGE>


                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Assets and Liabilities
February 29, 1996
- ----------------------------------------------------------------------------------------------------------------------------------
<CAPTION>
                                                                                      MULTI-SECTOR   FUNDAMENTAL     INTERNATIONAL
                                                                                          GROWTH        VALUE            EQUITY
                                                                                           FUND          FUND             FUND
                                                                                      ------------   -----------     ------------
<S>                                                                                    <C>            <C>             <C>        
Assets:
      Investments at value - Note C:
        Common stocks (cost - $7,307,108, $4,959,504 and $2,547,128, respectively)     $8,273,495     $5,185,108      $2,715,616
        Short-term investments (cost - $381,000, $121,000 and $190,000, respectively)     381,000        121,000         190,000
        Corporate savings account                                                             262            266              --
                                                                                       ----------     ----------      ----------
                                                                                        8,654,757      5,306,374       2,905,616
      Cash                                                                                     --             --             518
      Foreign currency, at value (cost - none, none and $103)                                  --             --             102
      Interest receivable                                                                      60             23              29
      Dividends receivable                                                                  1,530          5,107           4,991
      Deferred organization expenses - Note A                                               8,396          6,795           6,705
                                                                                       ----------     ----------      ----------
             Total Assets                                                               8,664,743      5,318,299       2,917,961
             -------------------------------------------------------------------------------------------------------------------
Liabilities:
      Payable for investments purchased                                                   224,027             --              --
      Payable for shares repurchased                                                           --             --             872
      Foreign tax payable                                                                      --             --             129
      Payable to John Hancock Advisers, Inc. and affiliates - Note B                       41,782         25,543          20,198
                                                                                       ----------     ----------      ----------
             Total Liabilities                                                            265,809         25,543          21,199
             -------------------------------------------------------------------------------------------------------------------
Net Assets:
      Capital paid-in                                                                   7,341,156      5,061,044       2,735,900
      Accumulated net realized gain (loss) on investments and foreign currency 
       transactions                                                                        91,391           (230)         (6,781)
      Net unrealized appreciation of investments and foreign currency transactions         96,387        225,604         168,456
      Undistributed net investment income (distributions in excess of net investment 
       income)                                                                                 --          6,338            (813)
                                                                                       ----------     ----------      ----------
             Net Assets                                                                $8,398,934     $5,292,756      $2,896,762
             ===================================================================================================================

Net Asset Value Per Share
    (based on 785,677, 582,012 and 313,634 shares, respectively,
    of beneficial interest outstanding - unlimited number of shares
    authorized with no par value)                                                      $    10.69     $     9.09      $     9.24
    ============================================================================================================================
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       29

<PAGE>

                              FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust

<TABLE>
Statements of Operations
Period ended February 29, 1996*
- --------------------------------------------------------------------------------------------------------------------------------
<CAPTION>
                                                                                            DIVIDEND       ACTIVE         GLOBAL
                                                                                           PERFORMERS       BOND           BOND
                                                                                              FUND          FUND           FUND
                                                                                           ----------     --------      ---------
<S>                                                                                         <C>           <C>           <C>   
Investment Income:
  Dividends                                                                                 $ 49,945      $     --      $     --
  Interest (net of foreign withholding tax of none, none and $113, respectively)              32,501        64,005         7,944
                                                                                            --------      --------      --------  
                                                                                              82,446        64,005         7,944
  Expenses:
    Registration and filing fees                                                              60,443        55,622        58,256
    Investment management fee - Note B                                                        15,229         4,469           876
    Custodian fee                                                                              8,809         8,463         7,268
    Printing                                                                                   7,286         7,951         5,575
    Auditing fee                                                                               7,000         7,000         7,000
    Organization expense - Note A                                                              1,525         1,512         1,397
    Transfer agent fee - Note B                                                                1,259           447            58
    Financial services fee                                                                        98            35             7
    Legal fees                                                                                    88            73            63
                                                                                            --------      --------      --------  
           Total Expenses                                                                    101,737        85,572        80,500
           Less Expenses Reimbursable by John Hancock Advisers, Inc. - Note B                (82,775)      (79,799)      (79,439)
                                                                                            --------      --------      --------  
           Net Expenses                                                                       18,962         5,773         1,061
           ---------------------------------------------------------------------------------------------------------------------
           Net Investment Income                                                              63,484        58,232         6,883
           ---------------------------------------------------------------------------------------------------------------------

Realized and Unrealized Gain (Loss) on Investments and Foreign Currency Transactions:
  Net realized gain on investments sold                                                       43,668         3,558         1,105
  Net realized loss on foreign currency transactions                                              --            --        (2,430)
  Change in net unrealized appreciation (depreciation) of investments                        465,809         9,391           (15)
  Change in net unrealized appreciation (depreciation) of foreign currency transactions           --            --          (433)
                                                                                            --------      --------      --------  
           Net Realized and Unrealized Gain (Loss) on Investments and
           Foreign Currency Transactions                                                     509,477        12,949        (1,773)
           ---------------------------------------------------------------------------------------------------------------------
           Net Increase in Net Assets Resulting from Operations                             $572,961      $ 71,181      $  5,110
           =====================================================================================================================


* Dividend Performers Fund and Active Bond Fund commenced investment operations on March 30, 1995. Global Bond Fund commenced 
investment operations on April 19, 1995.

</TABLE>

The Statement of Operations summarizes for each of the Funds, the investment
income earned and expenses incurred in operating the Fund. It also shows net
gains (losses) for the period stated.

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       30

<PAGE>

                             FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust
                                       

<TABLE>
Statements of Operations
Period ended February 29, 1996*
- --------------------------------------------------------------------------------------------------------------------------------
<CAPTION>
                                                                                        MULTI-SECTOR  FUNDAMENTAL  INTERNATIONAL
                                                                                           GROWTH        VALUE        EQUITY
                                                                                            FUND         FUND          FUND
                                                                                        ------------  -----------  -------------
<S>                                                                                     <C>             <C>           <C>     
Investment Income:
  Interest                                                                              $   23,782      $ 21,664      $ 19,380
  Dividends (net of foreign withholding tax of $60, $931 and $2,460, respectively)           5,884        42,598        16,711
                                                                                        ----------      --------      --------
                                                                                            29,666        64,262        36,091
  Expenses:
    Registration and filing fees                                                            61,477        60,249        59,624
    Investment management fee - Note B                                                      28,922        15,765        11,818
    Custodian fee                                                                           14,103         9,127        16,802
    Auditing fee                                                                             9,750         7,000         7,000
    Printing                                                                                 8,145         7,286         7,951
    Organization expense - Note A                                                            1,811         1,422         1,512
    Transfer agent fee - Note B                                                              1,806         1,125           646
    Financial services fee                                                                     216           167            84
    Legal fees                                                                                  78            68            70
                                                                                        ----------      --------      --------
         Total Expenses                                                                    126,308       102,209       105,507
         Less Expenses Reimbursable by John Hancock Advisers, Inc. - Note B                (92,922)      (83,656)      (92,015)
                                                                                        ----------      --------      --------
         Net Expenses                                                                       33,386        18,553        13,492
         ---------------------------------------------------------------------------------------------------------------------
         Net Investment Income (Loss)                                                       (3,720)       45,709        22,599
         ---------------------------------------------------------------------------------------------------------------------
         
Realized and Unrealized Gain (Loss) on Investments and Foreign Currency Transactions:
  Net realized gain (loss) on investments sold                                             100,214          (230)       (4,972)
  Net realized gain (loss) on foreign currency transactions                                  4,766            --        (2,564)
  Change in net unrealized appreciation (depreciation) of investments                      966,387       225,604       168,488
  Change in net unrealized appreciation (depreciation) of foreign
     currency transactions                                                                      --            --           (32)
         Net Realized and Unrealized Gain on Investments and Foreign 
           Currency Transactions                                                         1,071,367       225,374       160,920
         ---------------------------------------------------------------------------------------------------------------------
         Net Increase in Net Assets Resulting from Operations                           $1,067,647      $271,083      $183,519
         =====================================================================================================================


* Multi-Sector Growth Fund, Fundamental Value Fund and International Equity
Fund commenced investment operations on April 11, 1995, April 19, 1995 and March
30, 1995, respectively.

</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       31

<PAGE>


                             FINANCIAL STATEMENTS

                John Hancock Funds - Institutional Series Trust
<TABLE>

Statements of Changes in Net Assets
- ------------------------------------------------------------------------------------------------------------------------------------
<CAPTION>
                                                                                     DIVIDEND          ACTIVE           GLOBAL
                                                                                    PERFORMERS          BOND             BOND
                                                                                       FUND             FUND             FUND
                                                                                ----------------- ---------------- -----------------
                                                                                  PERIOD ENDED      PERIOD ENDED     PERIOD ENDED
                                                                                FEBRUARY 29, 1996 FEBRUARY 29,1996 FEBRUARY 29, 1996
                                                                                ----------------- ---------------- -----------------
<S>                                                                                <C>            <C>                 <C>     
Increase (Decrease) in Net Assets:                                                                                  
From Operations:                                                                                                    
  Net investment income                                                            $    63,484    $    58,232         $  6,883
  Net realized gain (loss) on investments sold and foreign currency transactions        43,668          3,558           (1,325)
  Change in net unrealized appreciation (depreciation) of investments and                                           
    foreign currency transactions                                                      465,809          9,391             (448)
                                                                                   -----------    -----------         --------
        Net Increase in Net Assets Resulting from Operations                           572,961         71,181            5,110
                                                                                   -----------    -----------         --------
                                                                                                                    
Distributions to Shareholders: *                                                                                    
  Dividends from net investment income                                                 (58,824)       (58,232)          (6,883)
  Distributions from net realized gain on investments sold                             (21,522)        (1,888)              --
                                                                                   -----------    -----------         --------
        Total Distributions to Shareholders                                            (80,346)       (60,120)          (6,883)
                                                                                   -----------    -----------         --------
                                                                                                                    
From Portfolio Share Transactions: **                                                                               
  Shares sold                                                                        5,484,852      2,151,742          289,031
  Shares issued to shareholders in reinvestment of distributions                        80,347         57,656            6,810
                                                                                   -----------    -----------         --------
                                                                                     5,565,199      2,209,398          295,841
  Less shares repurchased                                                           (2,738,594)    (1,049,832)         (77,327)
                                                                                   -----------    -----------         --------
        Net Increase                                                                 2,826,605      1,159,566          218,514
                                                                                   -----------    -----------         --------

Net Assets:                                                                                                         
  Beginning of period                                                                       --             --               --
                                                                                   -----------    -----------         --------
  End of period (including undistributed net investment income of $4,660, none                                        
    and distributions in excess of net investment income of $616, respectively)    $ 3,319,220    $ 1,170,627         $216,741
                                                                                   ===========    ===========         ========
* Distributions to Shareholders:                                                                                    
  Per share dividends from net investment income                                   $    0.1863    $    0.5144         $ 0.4059
                                                                                   -----------    -----------         --------
  Per share distributions from net realized gain on investments sold               $    0.0742    $    0.0152               --
                                                                                   -----------    -----------         --------
* Analysis of Portfolio Share Transactions:                                                                         
  Shares sold                                                                          627,033        252,193           33,983
  Shares issued to shareholders in reinvestment of distributions                         8,685          6,688              797
                                                                                   -----------    -----------         --------
                                                                                       635,712        258,881           34,780
  Less shares repurchased                                                             (308,820)      (123,444)          (9,167)
                                                                                   -----------    -----------         --------
                                                                                                                    
    Net increase                                                                       326,898        135,437           25,613
                                                                                   ===========    ===========         ========

[DAGGER]Dividend Performers Fund and Active Bond Fund commenced investment
operations on March 30, 1995. Global Bond Fund commenced investment operations
on April 19, 1995.

</TABLE>

The statement of changes in net assets shows how the value of each Fund's net
assets have changed since the commencement of operations. The difference
reflects net investment income, any investment gains and losses, distributions
paid to shareholders, and any increase or decrease in money shareholders
invested in each Fund. The footnotes illustrate the number of Fund shares sold,
reinvested and redeemed during the period, along with the per share amount of
distributions made to shareholders of each Fund for the period indicated.

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       32


<PAGE>

                              FINANCIAL STATEMENTS

                    John Hancock Funds Institutional Series Trust
<TABLE>

Statements of Changes in Net Assets
- -----------------------------------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                  MULTI-SECTOR     FUNDAMENTAL       INTERNATIONAL
                                                                                     GROWTH           VALUE              EQUITY
                                                                                      FUND            FUND                FUND
                                                                               ----------------  ----------------  ----------------
                                                                                  PERIOD ENDED     PERIOD ENDED       PERIOD ENDED
                                                                               FEBRUARY 29,1996  FEBRUARY 29,1996  FEBRUARY 29,1996
                                                                                   [DAGGER]          [DAGGER]          [DAGGER]
                                                                               ----------------  ----------------  ----------------
<S>                                                                                 <C>            <C>              <C>       
Increase (Decrease) in Net Assets:
From Operations:
  Net investment income (loss)                                                      $   (3,720)    $   45,709       $   22,599
  Net realized gain (loss) on investments sold and foreign currency transactions       104,980           (230)          (7,536)
  Change in net unrealized appreciation (depreciation) of investments                  966,387        225,604          168,456
                                                                                    ----------     ----------       ----------
    Net Increase in Net Assets Resulting from Operations                             1,067,647        271,083          183,519
                                                                                    ----------     ----------       ----------

Distributions to Shareholders: *
  Dividends from net investment income                                                      --        (39,371)         (20,847)
  Distributions from net realized gain on investments sold                              (9,869)            --           (1,810)
                                                                                    ----------     ----------       ----------
    Total Distributions to Shareholders                                                 (9,869)       (39,371)         (22,657)
                                                                                    ----------     ----------       ----------
From Portfolio Share Transactions: **
  Shares sold                                                                        7,818,477      5,729,142        3,965,415
  Shares issued to shareholders in reinvestment of distributions                         9,654         39,370           22,657
                                                                                    ----------     ----------       ----------
                                                                                     7,828,131      5,768,512        3,988,072

  Less shares repurchased                                                             (586,975)      (707,468)      (1,252,172) 
                                                                                    ----------     ----------       ----------
    Net Increase                                                                     7,241,156      5,061,044        2,735,900
                                                                                    ----------     ----------       ----------

Net Assets:
  Beginning of period                                                                  100,000[DOUBLE      --               --
                                                                                          DAGGER]  
                                                                                    ----------     ----------       ----------
  End of period (including undistributed net investment income of 
  none, $6,338 and distributions in excess of net investment income
  of $813, respectively)                                                            $8,398,934     $5,292,756       $2,896,762
                                                                                    ==========     ==========       ==========
* Distributions to Shareholders:
  Per share dividends from net investment income                                    $   0.0168     $   0.1380       $   0.0832
                                                                                    ----------     ----------       ----------
  Per share distributions from net realized gain on investments sold                        --             --       $   0.0072
                                                                                    ----------     ----------       ----------
** Analysis of Portfolio Share Transactions:
  Shares sold                                                                          833,819        656,980          449,585
  Shares issued to shareholders in reinvestment of distributions                           967          4,423            2,551
                                                                                    ----------     ----------       ----------
                                                                                       834,786        661,403          452,136
  Less shares repurchased                                                              (60,874)       (79,391)        (138,502)
                                                                                    ----------     ----------       ----------
    Net increase                                                                       773,912        582,012          313,634
                                                                                    ==========     ==========       ==========


[DAGGER] Multi-Sector Growth Fund, Fundamental Value Fund and International
Equity Fund commenced investment operations on April 11, 1995, April 19, 1995   
and March 30, 1995, respectively.

[DOUBLE DAGGER] On January 11, 1995, the Adviser made an initial investment of
$100,000 in order to seed the Trust.

</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       33

<PAGE>


                              FINANCIAL STATEMENTS

  John Hancock Funds - Institutional Series Trust -- Dividend Performers Fund

<TABLE>
Financial Highlights
Selected data for a share of beneficial interest outstanding throughout the
period indicated, investment returns, key ratios and supplemental data are
listed as follows:
- ----------------------------------------------------------------------------------------------------
<CAPTION>
                                                                       FOR THE PERIOD MARCH 30, 1995
                                                                        (COMMENCEMENT OF OPERATIONS)
                                                                             TO FEBRUARY 29, 1996
                                                                       -----------------------------

<S>                                                                            <C>      
Per Share Operating Performance
   Net Asset Value, Beginning of Period                                        $ 8.50(b)
                                                                               ------
   Net Investment Income                                                         0.23**
   Net Realized and Unrealized Gain on Investments                               1.68
                                                                               ------
       Total from Investment Operations                                          1.91
                                                                               ------
   Less Distributions:
     Dividends from Net Investment Income                                       (0.19)
     Distributions from Net Realized Gain on Investments Sold                   (0.07)
                                                                               ------
            Total Distributions                                                 (0.26)
                                                                               ------
   Net Asset Value, End of Period                                              $10.15
                                                                               ======

   Total Investment Return at Net Asset Value (e)                               22.79%(c)
   Total Adjusted Investment Return at Net Asset Value (a)(e)                   19.79%(c)

Ratios and Supplemental Data
   Net Assets, End of Period (000's omitted)                                   $3,319
   Ratio of Expenses to Average Net Assets                                       0.75%*
   Ratio of Adjusted Expenses to Average Net Assets (a)(d)                       4.02%*
   Ratio of Net Investment Income to Average Net Assets                          2.51%*
   Ratio of Adjusted Net Investment Loss to Average Net Assets (a)(d)           (0.76%)*
   Portfolio Turnover Rate                                                         70%


  *  On an annualized basis. 
 **  On average month end shares outstanding.
(a)  On an unreimbursed basis.
(b)  Initial price to commence operations.
(c)  Not annualized.
(d)  Adjusted expenses as a percentage of average net assets are expected to
     decrease and adjusted net investment income as a percentage of average net
     assets are expected to increase as the net assets of the Fund grow.
(e)  Total investment return assumes dividend reinvestment and does not reflect
     the effect of sales charges.

</TABLE>

The financial highlights summarizes the impact of the following factors on a
single share for the period indicated: net investment income, gains (losses),
dividends and total investment return of the Fund. It shows how the Fund's net
asset value for a share has changed since the commencement of operations.
Additionally, important relationships between some items presented in the
financial statements are expressed in ratio form.

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       34

<PAGE>

                              FINANCIAL STATEMENTS

      John Hancock Funds - Institutional Series Trust -- Active Bond Fund

<TABLE>
Financial Highlights
Selected data for a share of beneficial interest outstanding throughout the
period indicated, investment returns, key ratios and supplemental data are
listed as follows:
- --------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                           FOR THE PERIOD MARCH 30, 1995
                                                                            (COMMENCEMENT OF OPERATIONS)
                                                                                TO FEBRUARY 29, 1996
                                                                           ----------------------------- 

<S>                                                                                  <C>      
Per Share Operating Performance                                                     
  Net Asset Value, Beginning of Period                                               $ 8.50(b)
                                                                                     ------   
  Net Investment Income                                                                0.51
  Net Realized and Unrealized Gain on Investments                                      0.16
                                                                                     ------   
        Total from Investment Operations                                               0.67
                                                                                     ------   
  Less Distributions:                                                             
    Dividends from Net Investment Income                                              (0.51)
    Distributions from Net Realized Gain on Investments Sold                          (0.02)
                                                                                     ------   
        Total Distributions                                                           (0.53)
                                                                                     ------
                                                                                    
  Net Asset Value, End of Period                                                     $ 8.64
                                                                                     ======
                                                                                  
  Total Investment Return at Net Asset Value (e)                                       7.76%(c)
  Total Adjusted Investment Return at Net Asset Value (a)(e)                          (0.46%)(c)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                                          $1,171
  Ratio of Expenses to Average Net Assets                                              0.65%*
  Ratio of Adjusted Expenses to Average Net Assets (a)(d)                              9.60%*
  Ratio of Net Investment Income to Average Net Assets                                 6.53%*
  Ratio of Adjusted Net Investment Loss to Average Net Assets (a)(d)                  (2.42%)*
  Portfolio Turnover Rate                                                                71%

 
  *  On an annualized basis.
(a)  On an unreimbursed basis.
(b)  Initial price to commence operations.
(c)  Not annualized.
(d)  Adjusted expenses as a percentage of average net assets are expected to
     decrease and adjusted net investment income as a percentage of average net
     assets are expected to increase as the net assets of the Fund grow.
(e)  Total investment return assumes dividend reinvestment and does not reflect
     the effect of sales charges.
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       35


<PAGE>

                              FINANCIAL STATEMENTS

     John Hancock Funds - Institutional Series Trust -- Global Bond Fund

<TABLE>
Financial Highlights
Selected data for a share of beneficial interest outstanding throughout the
period indicated, investment returns, key ratios and supplemental data are
listed as follows:
- -------------------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                      FOR THE PERIOD APRIL 19, 1995
                                                                                     (COMMENCEMENT OF OPERATIONS)
                                                                                             TO FEBRUARY 29, 1996
                                                                                     ------------------------------

<S>                                                                                           <C>       
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                                        $  8.50(b)
                                                                                              -------   
  Net Investment Income                                                                          0.41
  Net Realized and Unrealized Loss on Investments and Foreign Currency Transactions             (0.04)
                                                                                              -------   
        Total from Investment Operations                                                         0.37
                                                                                              -------   
  Less Distributions:
    Dividends from Net Investment Income                                                        (0.41)
                                                                                              -------   
  Net Asset Value, End of Period                                                              $  8.46
                                                                                              =======
  Total Investment Return at Net Asset Value (e)                                                 4.37%(c)
  Total Adjusted Investment Return at Net Asset Value (a)(e)                                   (54.55%)(c)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                                                   $   217
  Ratio of Expenses to Average Net Assets                                                        0.91%*
  Ratio of Adjusted Expenses to Average Net Assets (a)(d)                                       69.15%*
  Ratio of Net Investment Income to Average Net Assets                                           5.91%*
  Ratio of Adjusted Net Investment Income to Average Net Assets (a)(d)                         (62.33%)*
  Portfolio Turnover Rate                                                                         129%


  *  On an annualized basis.
(a)  On an unreimbursed basis.
(b)  Initial price to commence operations.
(c)  Not annualized.
(d)  Adjusted expenses as a percentage of average net assets are expected to
     decrease and adjusted net investment income as a percentage of average net
     assets are expected to increase as the net assets of the Fund grow.
(e)  Total investment return assumes dividend reinvestment and does not reflect
     the effect of sales charges.
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       36

<PAGE>

                              FINANCIAL STATEMENTS

  John Hancock Funds - Institutional Series Trust -- Multi-Sector Growth Fund

<TABLE>
Financial Highlights
Selected data for a share of beneficial interest outstanding throughout the
period indicated, investment returns, key ratios and supplemental data are
listed as follows:
- ------------------------------------------------------------------------------------------------------------------------
<CAPTION>
                                                                                           FOR THE PERIOD APRIL 11, 1995
                                                                                           (COMMENCEMENT OF OPERATIONS)
                                                                                                TO FEBRUARY 29, 1996
                                                                                           -----------------------------
<S>                                                                                                <C>       
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                                             $  8.50(b)
                                                                                                   -------   
  Net Investment Loss                                                                                (0.01)**
  Net Realized and Unrealized Gain on Investments and Foreign Currency Transactions                   2.22
                                                                                                   -------   
     Total from Investment Operations                                                                 2.21
                                                                                                   -------   
  Less Distributions:
     Dividends from Net Investment Income                                                            (0.02)
                                                                                                   -------   
  Net Asset Value, End of Period                                                                   $ 10.69
                                                                                                   =======
  Total Investment Return at Net Asset Value (e)                                                     25.98%(c)
  Total Adjusted Investment Return at Net Asset Value (a)(e)                                         23.70%(c)
  
Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                                                        $ 8,399
  Ratio of Expenses to Average Net Assets                                                             0.93%*
  Ratio of Adjusted Expenses to Average Net Assets (a)(d)                                             3.51%*
  Ratio of Net Investment Loss to Average Net Assets                                                 (0.10%)*
  Ratio of Adjusted Net Investment Loss to Average Net Assets (a)(d)                                 (2.68%)*
  Portfolio Turnover Rate                                                                              189%
  
  *  On an annualized basis.
 **  On average month end shares outstanding.
(a)  On an unreimbursed basis.
(b)  Initial price to commence operations.
(c)  Not annualized.
(d)  Adjusted expenses as a percentage of average net assets are expected to
     decrease and adjusted net investment income as a percentage of average net
     assets are expected to increase as the net assets of the Fund grow.
(e)  Total investment return assumes dividend reinvestment and does not reflect
     the effect of sales charges.
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       37

<PAGE>

                              FINANCIAL STATEMENTS

   John Hancock Funds - Institutional Series Trust -- Fundamental Value Fund

<TABLE>
Financial Highlights
Selected data for a share of beneficial interest outstanding throughout the
period indicated, investment returns, key ratios and supplemental data are
listed as follows:
- -------------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                FOR THE PERIOD APRIL 19, 1995
                                                                                (COMMENCEMENT OF OPERATIONS)
                                                                                    TO FEBRUARY 29, 1996
                                                                                -----------------------------

<S>                                                                                  <C>      
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                               $ 8.50(b)
                                                                                     ------   
  Net Investment Income                                                                0.17**
  Net Realized and Unrealized Gain on Investments                                      0.56
                                                                                     ------   
        Total from Investment Operations                                               0.73
                                                                                     ------   
  Less Distributions:
        Dividends from Net Investment Income                                          (0.14)
                                                                                     ------   
  Net Asset Value, End of Period                                                     $ 9.09
                                                                                     ======

  Total Investment Return at Net Asset Value (e)                                       8.61%(c)
  Total Adjusted Investment Return at Net Asset Value (a)(e)                           5.40%(c)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                                          $5,293
  Ratio of Expenses to Average Net Assets                                              0.83%*
  Ratio of Adjusted Expenses to Average Net Assets (a)(d)                              4.55%*
  Ratio of Net Investment Income to Average Net Assets                                 2.04%*
  Ratio of Adjusted Net Investment Loss to Average Net Assets (a)(d)                  (1.68%)*
  Portfolio Turnover Rate                                                                 0%

  *  On an annualized basis.
 **  On average month end shares outstanding.
(a)  On an unreimbursed basis.
(b)  Initial price to commence operations.
(c)  Not annualized.
(d)  Adjusted expenses as a percentage of average net assets are expected to
     decrease and adjusted net investment income as a percentage of average net
     assets is expected to increase as the net assets of the Fund grow.
(e)  Total investment return assumes dividend reinvestment and does not reflect
     the effect of sales charges.

</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       38

<PAGE>

                              FINANCIAL STATEMENTS

 John Hancock Funds - Institutional Series Trust -- International Equity Fund

<TABLE>
Financial Highlights
Selected data for a share of beneficial interest outstanding throughout the
period indicated, investment returns, key ratios and supplemental data are
listed as follows:
- ------------------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                     FOR THE PERIOD MARCH 30, 1995
                                                                                     (COMMENCEMENT OF OPERATIONS)
                                                                                          TO FEBRUARY 29, 1996
                                                                                     -----------------------------

<S>                                                                                           <C>      
Per Share Operating Performance
  Net Asset Value, Beginning of Period                                                        $ 8.50(b)
                                                                                              ------   
  Net Investment Income                                                                         0.15**
  Net Realized and Unrealized Gain on Investments and Foreign Currency Transactions             0.68
                                                                                              ------   
    Total from Investment Operations                                                            0.83
                                                                                              ------   
  Less Distributions:
  Dividends from Net Investment Income                                                         (0.08)
  Distributions from Net Realized Gain on Investments Sold                                     (0.01)
                                                                                              ------   
        Total Distributions                                                                    (0.09)
                                                                                              ------   
  Net Asset Value, End of Period                                                              $ 9.24
                                                                                              ======
  
  Total Investment Return at Net Asset Value (e)                                                9.81%(c)
  Total Adjusted Investment Return at Net Asset Value (a)(e)                                    3.26%(c)

Ratios and Supplemental Data
  Net Assets, End of Period (000's omitted)                                                   $2,897
  Ratio of Expenses to Average Net Assets                                                       1.05%*
  Ratio of Adjusted Expenses to Average Net Assets (a)(d)                                       8.19%*
  Ratio of Net Investment Income to Average Net Assets                                          1.75%*
  Ratio of Adjusted Net Investment Loss to Average Net Assets (a)(d)                           (5.39%)*
  Portfolio Turnover Rate                                                                         59%
  
  *  On an annualized basis.
 **  On average month end shares outstanding.
(a)  On an unreimbursed basis.
(b)  Initial price to commence operations.
(c)  Not annualized.
(d)  Adjusted expenses as a percentage of average net assets are expected to
     decrease and adjusted net investment income as a percentage of average net
     assets are expected to increase as the net assets of the Fund grow.
(e)  Total investment return assumes dividend reinvestment and does not reflect
     the effect of sales charges.
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       39


<PAGE>
                             FINANCIAL STATEMENTS

 John Hancock Funds - Institutional Series Trust -- Dividend Performers Fund

<TABLE>

Schedule of Investments
February 29, 1996 
Per share earnings and dividends, price/earnings ratios, company descriptions and their compound growth rates are
shown for the most recently reported ten year periods on common stocks and are unaudited.
- -----------------------------------------------------------------------------------------------------------------
<CAPTION>
                                                                                             COMPOUND
  NUMBER                                                                                      GROWTH        MARKET
OF SHARES    COMMON STOCKS (87.93%)                                                            RATE         VALUE
- ---------                                                                                      ----         -----

<S>          <C>                                                                               <C>         <C>
Advertising (2.28%)
 1,800       Interpublic Group Inc. @ 42 1/8                                                               $ 75,825
             One of the largest advertising agencies in                                                    --------
             the world
             Earnings P/S       $ .62, .75, .91, 1.05, 1.19, 1.30, 1.37, 1.67,1.86, 1.66       10.3% 
             Dividends P/S            $ .20, .22, .26, .32, .37, .41, .45, .49, .55, .61       13.2% 
             Price/Earnings Ratio                                                   26.7

Aerospace (0.69%)
   400       Rockwell International Corp. @ 57                                                               22,800
             Leading producer of aerospace, automotive                                                      -------
             and electronics products
             Earnings P/S     $1.98, 2.23, 3.01, 2.84, 2.56, 2.57, 2.16, 2.53, 2.87, 3.42       6.3%
             Dividends P/S            $.59, .66, .72, .77, .82, .88, .92, .98, 1.04, 1.10       7.2%
             Price/Earnings Ratio                                                    16.5

Banks (5.87%)
   770       Banc One Corp. @ 35 5/8                                                                         27,431
             Ohio-based bank holding company
             Earnings P/S     $1.16, 1.19, 1.56, 1.66, 1.66, 1.72, 2.08, 2.61, 2.20, 2.91       9.6%
             Dividends P/S            $.41, .45, .50, .57, .63, .70, .81, .98, 1.13, 1.24      11.7%
             Price/Earnings Ratio                                                    12.0

 1,200       First Tennessee National Corp. @ 31 1/2                                                         37,800
             Tennessee-based bank holding company
             Earnings P/S       $1.01, .78, 1.10, .65, 1.00, 1.35, 1.60, 1.66, 2.25, 2.43       9.2%
             Dividends P/S        $ .375, .395, .425, .485, .54, .57, .63, .75, .865, .97      10.0%
             Price/Earnings Ratio                                                    13.1

   700       KeyCorp. @ 37 5/8                                                                               26,338
             Multi-regional bank holding company
             Earnings P/S     $1.72, 1.88, 2.10, 2.32, 2.32, 2.45, 2.42, 2.89, 3.45, 3.30       6.7%
             Dividends P/S           $.48, .60, .68, .80, .88, .92, .98, 1.12, 1.28, 1.44      13.0%
             Price/Earnings Ratio                                                    11.4

 1,400       NationsBank Corp. @ 73 3/4                                                                     103,250
             Largest superregional bank in the Southeast
             Earnings P/S      $2.51, 2.01, 2.87, 4.44, 2.61, .81, 4.60, 5.00, 6.11, 7.13      11.0%
             Dividends P/S      $ .78, .86, .94, 1.10, 1.42, 1.48, 1.51, 1.64, 1.88, 2.08      11.5%
             Price/Earnings Ratio                                                    10.5
                                                                                                           --------
                                                                                                            194,819
                                                                                                           --------

Chemicals (5.78%)
 1,300       Air Products & Chemicals, Inc. @ 53 1\4                                                         69,225
             Producer of industrial and specialty 
             chemicals and gases
             Earnings P/S      $1.18, .04, 1.95, 2.02, 2.08, 2.23, 2.45, 1.76, 2.05, 3.29      12.1%
             Dividends P/S             $.39, .45, .55, .63, .69, .75, .83, .89, .95, 1.01      10.0%
             Price/Earnings Ratio                                                    17.1

</TABLE>


The Schedule of Investments is a complete list of all securities owned by 
Dividend Performers Fund on February 29, 1996. Its divided into three main 
categories: common stocks, preferred stocks and short-term investments. The 
common stocks are further broken down by industry groups. Short-term 
investments, which represent the Fund's "cash" position are listed last.
<TABLE>
<CAPTION>                          

                                                                                             COMPOUND
  NUMBER                                                                                      GROWTH        MARKET
OF SHARES                    COMMON STOCKS                                                     RATE         VALUE
- ---------                                                                                      ----         -----

<S>          <C>                                                                               <C>         <C>
Chemicals (continued)
   700       E.I. du Pont de Nemours and Co. @ 76 1/2                                                      $ 53,550
             Nation's largest chemical manufacturer
             Earnings P/S      $2.12, 2.46, 3.03, 3.53, 3.40, 2.08, 1.43, .83, 4.00, 5.61      10.2%
             Dividends P/S   $ 1.02, 1.10, 1.23, 1.45, 1.62, 1.68, 1.74, 1.76, 1.82, 2.03       8.0%
             Price/Earnings Ratio                                                    14.7

   600       PPG Inds., Inc. @ 46 3/8                                                                        27,825
             Manufacturer of specialty chemicals, 
             coatings and resins
             Earnings P/S     $ 1.33, 1.60, 2.13, 2.09, 2.22, .95, 1.51, 1.39, 2.44, 3.80      11.1%
             Dividends P/S          $ .47, .56, .64, .74, .82, .86, .94, 1.04, 1.12, 1.18      10.8%
             Price/Earnings Ratio                                                    12.8

 1,250       RPM, Inc. @ 14 3/4                                                                              18,438
             Manufacturer of specialty chemicals and 
             coatings to waterproof and rustproof 
             structures
             Earnings P/S              $ .34, .38, .45, .52, .43, .45, .54, .58, .79, .87      11.0%
             Dividends P/S              $.18, .21, .25, .27, .30, .34, .37, .39, .42, .46      11.0%
             Price/Earnings Ratio                                                    16.8

   400       Sigma-Aldrich Corp. @ 57 1/4                                                                    22,900
             Manufacturer of biochemical and organic 
             products used for research and diagnostics
             Earnings P/S      $ .69, .85, 1.15, 1.30, 1.13, 1.60, 1.92, 2.15, 2.21, 2.64      14.4%
             Dividends P/S             $ .13, .15, .17, .19, .20, .23, .26, .30, .34, .38      12.7%
             Price/Earnings Ratio                                                    22.3
                                                                                                           --------
                                                                                                            191,938
                                                                                                           --------

Commercial Services (2.48%)
 2,500       Sysco Corp. @ 32 7/8                                                                            82,188
             Largest distributer of food service products                                                  --------
             Earnings P/S           $ .35, .45, .60, .73, .76, .86, .95, 1.10, 1.24, 1.42      16.8% 
             Dividends P/S             $ .06, .07, .08, .09, .10, .14, .22, .28, .36, .44      24.8% 
             Price/Earnings Ratio                                                    22.7

Computer & Office Equipment (2.28%)
 1,600       Alco Standard Corp @ 47 3/8                                                                     75,800
             Distributor of office and paper products                                                      --------
             Earnings P/S       $ .64, .84, 1.15, 1.96, .91, .98, 1.11, (.025), .56, 1.82      12.3% 
             Dividends P/S       $ .315, .325, .35, .39, .425, .445, .465, .485, .51, .53       6.0%
             Price/Earnings Ratio                                                    26.1
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       40

<PAGE>
                             FINANCIAL STATEMENTS

 John Hancock Funds - Institutional Series Trust -- Dividend Performers Fund
<TABLE>
<CAPTION>

                                                                                          COMPOUND
  NUMBER                                                                                   GROWTH        MARKET
OF SHARES COMMON STOCKS                                                                     RATE         VALUE
- ---------                                                                                   ----         -----

<S>       <C>                                                                               <C>         <C>
Consumer Cyclicals & Services (1.68%)
   700    Albertson's,Inc. @ 37                                                                         $ 25,900
          Idaho-based operator of supermarkets and 
          combination food-drug stores
          Earnings P/S           $.38, .47, .61, .74, .88, .97, 1.05, 1.34, 1.65, 1.84      17.1% 
          Dividends P/S             $ .10, .12, .14, .19, .23, .27, .31, .35, .42, .50      19.6% 
          Price/Earnings Ratio                                                    21.0

   600    McDonald's Corp @ 50                                                                            30,000
          Dominant force in the fast food industry
          Earnings P/S         $.63, .73, .86, .98, 1.10, 1.18, 1.30, 1.46, 1.68, 1.98      12.1%
          Dividends P/S             $ .11, .12, .14, .15, .17, .18, .20, .21, .23, .26      10.0%
          Price/Earnings Ratio                                                    26.2
                                                                                                        --------
                                                                                                          55,900
                                                                                                        --------

Consumer Durables (1.13%)
 1,600    Leggett & Platt, Inc. @ 23 3/8                                                                  37,400
          Produces intermediate products for the                                                        --------
          home furnishings industry
          Earnings P/S       $ .475, .555, .545, .645, .42, .56, .82, 1.05, 1.39, 1.59      12.8% 
          Dividends P/S           $ .10, .14, .16, .185, .21, .215, .23, .27, .31, .38       9.4%
          Price/Earnings Ratio                                                    15.5

Consumer Non-Durables (12.62%)
 1,000    Archer-Daniels-Midland Co. @ 19 1/4                                                             19,250
          Major factor in soybean processing, corn 
          refining and flour milling
          Earnings P/S            $ .49, .65, .79, .89, .79, .82, .83, .84, 1.05, 1.50      13.2%
          Dividends P/S    $.027, .029, .030, .036, .050, .053, .056, .058, .069, .121      18.1%
          Price/Earnings Ratio                                                    12.2

   600    Campbell Soup Co. @ 61 3/4                                                                      37,050
          Leading food manufacturer and distributor
          Earnings P/S        $ .96, .94, .05, .02, 1.05, 1.68, 2.04, 1.08, 2.64, 2.89      13.0% 
          Dividends P/S           $ .33, .36, .42, .46, .50, .58, .76, .97, 1.12, 1.24      15.9% 
          Price/Earnings Ratio                                                    20.9

 1,000    CPC International Inc. @ 69 1/4                                                                 69,250
          Major international food processor
          Earnings P/S    $ 1.15, 2.17, 1.84, 2.11, 2.42, 2.61, 2.78, 2.95, 2.25, 3.43      11.5%
          Dividends P/S   $ .5675, .645, .76, .875, 1.00, 1.10, 1.20, 1.28, 1.38, 1.48      11.2%
          Price/Earnings Ratio                                                    20.3

   750    H.J. Heinz Co. @ 34                                                                             25,500
          Leading food manufacturer and distributor
          Earnings P/S    $ 1.24, 1.46, 1.67, 1.90, 1.34, 1.65, 1.43, 1.49, 1.46, 1.69       3.5%
          Dividends P/S            $ .32, .39, .45, .52, .60, .68, .76, .84, .92, 1.01      13.6%
          Price/Earnings Ratio                                                    20.0

   600    Kimberly-Clark Corp. @ 76 3/8                                                                   45,825
          Leading producer of consumer and personal care products
          Earnings P/S    $ 1.47, 1.87, 2.36, 2.63, 2.70, 3.01, 3.37, 1.95, 3.55, 3.66      10.7%
          Dividends P/S      $ .60, .70, .78, 1.26, 1.32, 1.48, 1.59, 1.67, 1.71, 1.76      12.7%
          Price/Earnings Ratio                                                    21.5

 1,600    PepsiCo, Inc. @ 63 1/4                                                                         101,200
          Second largest soft drink company
          Earnings P/S       $ .58, .76, .97, 1.13, 1.37, 1.35, 1.61, 1.96, 2.22, 2.00      13.2%
          Dividends P/S             $ .21, .22, .27, .32, .38, .46, .51, .61, .70, .78      15.7%
          Price/Earnings Ratio                                                    31.6

 1,000    Procter & Gamble Co. (The) @ 82                                                               $ 82,000
          Leading producer of household consumer products
          Earnings P/S       $.46, 1.48, 1.74, 2.25, 2.42, 2.49, 2.50, .74, 2.21, 4.05      24.3%
          Dividends P/S        $ .67, .68, .70, .83, .93, 1.00, 1.08, 1.17, 1.32, 1.50       9.4%
          Price/Earnings Ratio                                                    21.3

 1,200    Sara Lee Corp. @ 32 3/8                                                                         38,850
          Manufacturer of brand name packaged food 
          and consumer products
          Earnings P/S          $ .59, .71, .88, .94, .98, 1.41, 1.28, 1.43, .46, 1.66      12.2%
          Dividends P/S             $ .20, .25, .30, .36, .42, .47, .50, .58, .64, .68      14.6%
          Price/Earnings Ratio                                                    19.3
                                                                                                        --------
                                                                                                         418,925
                                                                                                        --------

Diversified Operations (1.26%)
   500    Corning Inc. @ 32 1/2                                                                           16,250
          Operations are in laboratory services, fiber 
          optics, specialty materials and consumer products
          Earnings P/S    $.93, 1.03, 1.63, 1.40, 1.54, 1.66, 1.40, (.09), 1.32, (.23)        NMF
          Dividends P/S             $ .35, .36, .38, .41, .46, .53, .62, .68, .69, .72       8.3%
          Price/Earnings Ratio                                                    19.3

 1,000    Federal Signal Corp. @ 25 1/2                                                                    25,500
          Manufactures fire trucks and street 
          sweepers, as well as public safety, signaling 
          and communications equipment
          Earnings P/S            $ .26, .32, .41, .50, .61, .68, .68, .85, 1.02, 1.14      15.9%
          Dividends P/S             $ .14, .15, .16, .19, .22, .27, .32, .36, .42, .50      15.2%
          Price/Earnings Ratio                                                    24.1
                                                                                                         --------
                                                                                                           41,750
                                                                                                         --------

Electrical Equipment (10.51%)
 1,500    AMP Inc. @ 42 5/8                                                                                63,937
          World's largest manufacturer of 
          electrical/electronic connectors
          Earnings P/S     $ .75, 1.16, 1.48, 1.32, 1.35, 1.23, 1.38, 1.42, 1.76, 1.98      10.2%
          Dividends P/S             $ .37, .43, .50, .60, .68, .72, .76, .80, .84, .92      10.7%
          Price/Earnings Ratio                                                    21.7

   900    Emerson Electric Co. @ 77 7/8                                                                    70,088
          Produces and sells electrical/electronic products and systems
          Earnings P/S    $ 1.87, 2.00, 2.31, 2.63, 2.75, 2.83, 2.96, 3.15, 4.04, 4.16       9.3%
          Dividends P/S     $ .93, .98, 1.03, 1.16, 1.28, 1.34, 1.40, 1.47, 1.60, 1.84       7.9%
          Price/Earnings Ratio                                                    19.6

 2,300    General Electric Co. @ 75 1/2                                                                   173,650
          Dominant force in home appliances, 
          electrical power, and financial services
          Earnings P/S     $1.37, 1.60, 1.88, 2.18, 2.43, 2.56, 2.51, 2.46, 3.46, 3.91      11.1% 
          Dividends P/S        $ .58, .65, .70, .82, .94, 1.02, 1.12, 1.26, 1.44, 1.64      12.2% 
          Price/Earnings Ratio                                                    19.9
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       41

<PAGE>
                             FINANCIAL STATEMENTS

  John Hancock Funds - Institutional Series Trust -- Dividend Performers Fund

<TABLE>
<CAPTION>

                                                                                          COMPOUND
  NUMBER                                                                                   GROWTH        MARKET
OF SHARES COMMON STOCKS                                                                     RATE         VALUE
- ---------                                                                                   ----         -----

<S>       <C>                                                                               <C>         <C>

Electrical Equipment (continued)
   600    W.W. Grainger, Inc. @ 68 3/8                                                                  $ 41,025
          Leading distributor of electrical equipment
          Earnings P/S    $ 1.24, 1.48, 1.57, 1.96, 2.31, 2.38, 2.58, 2.88, 2.50, 3.64      11.4%
          Dividends P/S             $ .36, .39, .43, .50, .57, .61, .65, .71, .78, .89      10.6%
          Price/Earnings Ratio                                                    19.1
                                                                                                        --------
                                                                                                         348,700
                                                                                                        --------
Energy (2.63%)
   700    Exxon Corp. @ 79 1/2                                                                            55,650
          Major factor in the crude oil, natural gas and 
          chemical industry
          Earnings P/S    $ 3.71, 3.43, 3.95, 2.32, 3.96, 4.45, 3.82, 4.21, 4.07, 5.18       2.7%
          Dividends P/S   $ 1.80, 1.90, 2.15, 2.30, 2.47, 2.68, 2.83, 2.88, 2.91, 3.00       5.8%
          Price/Earnings Ratio                                                    15.7

 1,000    Questar Corp. @ 31 1/2                                                                          31,500
          Diversified holding company for Utah, 
          Wyoming and Colorado natural gas 
          transmission, distribution and storage
          Earnings P/S      $ 1.20, .67, .64, 1.27, 1.44, 1.63, 1.85, 2.10, 1.21, 2.05       5.5%
          Dividends P/S        $ .87, .91, .94, .95, .97, 1.01, 1.04, 1.09, 1.13, 1.16       2.9%
          Price/Earnings Ratio                                                    15.8
                                                                                                        --------
                                                                                                          87,150
                                                                                                        --------

Healthcare (11.20%)
 2,100    Abbott Laboratories @ 41 3/4                                                                    87,675
          Major pharmaceutical and healthcare firm
          Earnings P/S        $ .58, .70, .84, .97, 1.11, 1.27, 1.47, 1.69, 1.87, 2.12      15.5%
          Dividends P/S             $ .20, .24, .29, .34, .40, .48, .58, .66, .74, .82      17.0%
          Price/Earnings Ratio                                                    19.5

   500    American Home Products Corp. @ 98 1/2                                                           49,250
          Leading manufacturer of ethical pharmaceuticals
          Earnings P/S  $ 2.73, (2.64), 3.22, 3.54, 6.01, 4.36, 3.67, 4.73, 4.97, 5.45       7.2%
          Dividends P/S   $ 1.55, 1.67, 1.80, 1.95, 2.15, 2.38, 2.66, 2.86, 2.94, 3.02       7.7%
          Price/Earnings Ratio                                                    18.1

 1,100    Johnson & Johnson @ 93 1/2                                                                     102,850
          Major producer of prescription and non-
          prescription drugs, toiletries, medical 
          instruments and supplies
          Earnings P/S      $.45, 1.18, 1.41, 1.60, 1.71, 2.20, 2.46, 2.74, 3.12, 3.72      23.5% 
          Dividends P/S          $ .34, .40, .48, .56, .66, .77, .89, 1.01, 1.13, 1.28      15.9% 
          Price/Earnings Ratio                                                    25.4

 1,000    Merck & Co., Inc. @ 66 1/4                                                                      66,250
          World's largest ethical drug manufacturer
          Earnings P/S      $ .54, .74, 1.02, 1.26, 1.52, 1.83, 2.12, 1.87, 2.38, 2.70      17.5% 
          Dividends P/S          $ .21, .27, .43, .55, .64, .77, .92, 1.03, 1.14, 1.24      21.8% 
          Price/Earnings Ratio                                                    23.2

 1,000    Pfizer Inc. @ 65 5/8                                                                            65,875
          Leading ethical pharmaceutical producer
          Earnings P/S      $.98, 1.02, 1.18, 1.01, 1.19, 1.07, 1.63, 1.03, 2.09, 2.48       9.7%
          Dividends P/S            $ .41, .45, .50, .55, .60, .66, .74, .84, .94, 1.04      10.9%
          Price/Earnings Ratio                                                    25.7
                                                                                                        --------
                                                                                                         371,900
                                                                                                        --------

Information Processing (3.93%)
 1,600    Automatic Data Processing, Inc. @ 38 3/4                                                      $ 62,000
          Largest independent computing services firm in the U.S.
          Earnings P/S           $ .42, .54, .62, .72, .74, .83, .94, 1.07, 1.22, 1.43      14.6%
          Dividends P/S      $ .093, .105, .125, .145, .17, .195, .225, .255, .29, .35      15.9%
          Price/Earnings Ratio                                                    27.3

 1,200    General Motors Corp. Class E @ 57 1/8                                                           68,550 
          Leading provider of information processing
          services 
          Earnings P/S         $.53, .66, .79, .91, 1.04, 1.15, 1.33, 1.51, 1.71, 1.96      14.0%
          Dividends P/S             $ .10, .13, .17, .24, .28, .32, .36, .40, .48, .52      20.1% 
          Price/Earnings Ratio                                                    29.3
                                                                                                        --------
                                                                                                         130,550
                                                                                                        --------

Insurance (5.61%)
   800    AFLAC Corp. @ 46 3/8                                                                            37,100
          Global specialty insurer
          Earnings P/S        $.78, .93, 1.08, .80, 1.16, 1.46, 1.79, 2.32, 2.83, 3.52      16.3% 
          Dividends P/S             $ .16, .18, .20, .23, .26, .30, .34, .39, .45, .51      13.8% 
          Price/Earnings Ratio                                                    13.1

   400    American International Group @ 96 5/8                                                           38,650
          Broadly based property-casualty insurance organization
          Earnings P/S    $ 3.35, 3.92, 4.42, 4.61, 3.08, 3.24, 3.40, 4.03, 4.58, 5.31       4.7%
          Dividends P/S   $ .081, .093, .125, .157, .183, .209, .236, .258, .287, .323      16.6%
          Price/Earnings Ratio                                                    17.4

   500    Chubb Corp. @ 97 1/8                                                                            48,562
          Broadly based property-casualty insurance organization
          Earnings P/S     $3.53, 3.97, 4.27, 4.91, 6.07, 6.55, 6.40, 4.32, 5.99, 7.44       8.6%
          Dividends P/S     $ .80, .89, 1.08, 1.16, 1.32, 1.48, 1.60, 1.72, 1.84, 1.96      10.5%
          Price/Earnings Ratio                                                    13.1

   200    Providian Corp. @ 46 1/4                                                                         9,250
          Broadly based property-casualty insurance organization
          Earnings P/S     $1.60, 1.75, 2.00, 2.31, 1.70, 2.67, 3.14, 3.13, 3.01, 3.61       8.5%
          Dividends P/S             $ .41, .44, .47, .50, .54, .60, .66, .73, .80, .90       8.2%
          Price/Earnings Ratio                                                    12.2

 1,100    Reliastar Financial Corp. @ 48                                                                  52,800
          Financial services company engaged in 
          life/health insurance and consumer finance
          Earnings P/S     $2.29, 1.86, 1.58, 2.07, 2.09, 1.71, 2.06, 2.62, 3.30, 4.36       6.7%
          Dividends P/S             $ .43, .47, .57, .59, .65, .69, .73, .79, .88, .98       9.6%
          Price/Earnings Ratio                                                    10.8
                                                                                                        --------
                                                                                                         186,362
                                                                                                        --------

Media and Information Services (1.64%)
   800    Gannett Co., Inc @ 68                                                                           54,400
          Publishes 81 daily/50 nondaily newspapers,                                                    --------
          operates 10 TV, 8 FM and 7 AM stations
          Earnings P/S    $ 1.71, 1.98, 2.26, 2.47, 2.36, 2.00, 2.40, 2.73, 3.25, 3.42       7.2%
          Dividends P/S     $ .86, .94, 1.02, 1.11, 1.21, 1.24, 1.26, 1.30, 1.34, 1.38       5.4%
          Price/Earnings Ratio                                                    20.3
</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       42

<PAGE>
                             FINANCIAL STATEMENTS

  John Hancock Funds - Institutional Series Trust -- Dividend Performers Fund

<TABLE>
<CAPTION>
                                                                                          COMPOUND
  NUMBER                                                                                   GROWTH        MARKET
OF SHARES COMMON STOCKS                                                                     RATE         VALUE
- ---------                                                                                   ----         -----

<S>       <C>                                                                               <C>         <C>

Packaging (2.53%)
 1,400    Bemis Company, Inc. @ 30 5/8                                                                  $ 42,875
          Producer of a broad range of flexible 
          packaging and equipment and pressure 
          sensitive materials
          Earnings P/S          $ .47, .59, .74, .90, .99, 1.03, 1.10, .89, 1.40, 1.63      13.2% 
          Dividends P/S              $.15, .18, .22, .30, .36, .42, .46, .50, .54, .64      17.5% 
          Price/Earnings Ratio                                                    18.4

 1,500    Sonoco Products Corp. @ 27 3/8                                                                  41,062
          Leading manufacturer of containers, paper 
          products and packaging
          Earnings P/S        $ .63, .77, 1.10, 1.18, .55, 1.05, .89, 1.25, 1.31, 1.70      10.4%
          Dividends P/S             $ .18, .21, .30, .39, .43, .44, .48, .50, .53, .59      14.1%
          Price/Earnings Ratio                                                    16.6
                                                                                                        --------
                                                                                                          83,937
                                                                                                        --------

Retail (4.78%)
   900    Lowe's Companies, Inc. @ 31                                                                     27,900
          Retailer of building materials and supplies, 
          lumber, hardware and appliances
          Earnings P/S          $ .36, .39, .46, .51, .48, .044, .581, .90, 1.45, 1.41      14.6%
          Dividends P/S      $ .0975, .105, .1125, .12, .13, .135, .14, .16, .17, .185       7.4%
          Price/Earnings Ratio                                                    25.4

   800    May Dept. Stores Co. (The) @ 46 5/8                                                             37,300
          Operates 318 department stores and 3,295 shoe stores
          Earnings P/S    $ 1.22, 1.45, 1.82, 1.75, 2.00, 2.01, 2.36, 2.77, 3.06, 3.00       9.4%
          Dividends P/S           $ .51, .56, .62, .69, .77, .81, .83, .90, 1.01, 1.12       9.1%
          Price/Earnings Ratio                                                    16.8

 1,700    Pep Boys - Manny, Moe & Jack
          (The) @ 30                                                                                      51,000
          Retailer of automotive parts and accessories
          Earnings P/S           $ .52, .62, .76, .63, .70, .64, .87, 1.01, 1.27, 1.33      11.0% 
          Dividends P/S             $ .07, .08, .09, .11, .12, .13, .14, .15, .17, .19      11.7% 
          Price/Earnings Ratio                                                    23.6

 2,000    Wal-Mart Stores, Inc. @ 21 1/4                                                                  42,500
          Operates chain of discount department stores
          Earnings P/S            $.20, .28, .37, .48, .57, .69, .87, 1.03, 1.18, 1.20      19.6%
          Dividends P/S            $ .021, .03, .04, .06, .07, .09, .11, .13, .17, .20      30.7%
          Price/Earnings Ratio                                                    19.9
                                                                                                        --------
                                                                                                         158,700
                                                                                                        --------

Steel (0.52%)
   800    Worthington Industries, Inc. @ 21 1/2                                                           17,200
          Processor of close-tolerance steel                                                            --------
          Earnings P/S             $ .45, .61, .70, .60, .61, .50, .63, .74, .94, 1.29      11.1%
          Dividends P/S             $ .14, .17, .19, .23, .26, .28, .32, .34, .39, .43      11.9%
          Price/Earnings Ratio                                                    18.3

Telecommunications (2.85%)
 1,000    ALLTEL Corp. @ 33 1/4                                                                           33,250
          One of the country's largest telephone 
          systems
          Earnings P/S      $ .53, 1.00, .94, 1.13, 1.18, 1.12, 1.22, 1.39, 1.43, 1.86      13.4%
          Dividends P/S             $ .44, .45, .51, .57, .64, .70, .74, .80, .88, .96       9.1%
          Price/Earnings Ratio                                                    16.4

 1,500    Frontier Corp. @ 30                                                                           $ 45,000
          Provides telephone service to the city of 
          Rochester N.Y. and outlying areas
          Earnings P/S         $.89, .93, 1.06, .99, .86, 1.18, 1.06, 1.21, 1.42, 1.02       1.4% 
          Dividends P/S             $ .64, .66, .68, .71, .73, .75, .77, .79, .81, .83       2.9% 
          Price/Earnings Ratio                                                    29.9

   300    SBC Communications, Inc. @ 54 7/8                                                               16,462
          Provides telephone service throughout the 
          United States and internationally
          Earnings P/S    $ 1.71, 1.74, 1.76, 1.82, 1.84, 1.93, 2.17, 2.39, 2.74, 3.10       6.1%
          Dividends P/S   $ 1.05, 1.14, 1.22, 1.29, 1.36, 1.41, 1.45, 1.50, 1.56, 1.63       5.0%
          Price/Earnings Ratio                                                    17.0
                                                                                                        --------
                                                                                                          94,712
                                                                                                        --------

Tobacco (1.79%)
   600    Philip Morris Cos., Inc. @ 99                                                                   59,400
          Global tobacco, brewing and food company                                                      --------
          Earnings P/S    $ 1.55, 1.94, 2.22, 3.18, 3.83, 4.24, 5.45, 4.06, 5.45, 6.51      15.4%
          Dividends P/S     $ .62, .79, 1.01, 1.25, 1.55, 1.91, 2.35, 2.60, 3.03, 3.65      21.8%
          Price/Earnings Ratio                                                    13.5

Transportation - Rail (0.27%)
   200    CSX Corp. @ 44 7/8                                                                               8,975
          Nation's third largest rail system                                                            --------
          Earnings P/S   $ 2.73, 2.78, (.30), 4.11, 1.82, (.34), .10, 1.73, 3.12, 2.94       0.7% 
          Dividends P/S             $ .58, .58, .62, .64, .70, .72, .76, .79, .88, .92       4.7% 
          Price/Earnings Ratio                                                    16.2

Utilities (3.60%)
 1,000    Central and South West Corp. @ 27 3/4                                                           27,750
          Dallas-based utility holding company
          Earnings P/S    $ 1.88, 1.96, 1.72, 1.63, 1.90, 1.99, 2.03, 1.40, 2.08, 2.10       1.1%
          Dividends P/S   $ 1.07, 1.14, 1.22, 1.30, 1.38, 1.46, 1.54, 1.62, 1.70, 1.72       5.4%
          Price/Earnings Ratio                                                    13.0

   500    Florida Progress Corp. @ 35 3/8                                                                 17,687
          Holding Co. for Florida Power electric utility services
          Earnings P/S    $ 2.47, 2.49, 2.35, 2.39, 2.33, 2.15, 2.05, 2.22, 2.27, 2.50       0.1%
          Dividends P/S   $ 1.54, 1.61, 1.67, 1.72, 1.78, 1.84, 1.90, 1.95, 1.99, 2.02       3.1%
          Price/Earnings Ratio                                                    13.5

   800    National Fuel Gas Co. @ 32 1/8                                                                  25,700
          Integrated natural gas system serves the 
          Buffalo, New York area and contiguous 
          districts reaching into western Pennsylvania 
          and eastern Ohio
          Earnings P/S    $ 1.75, 1.49, 1.65, 1.93, 1.83, 1.68, 1.94, 2.21, 2.23, 2.03       1.7%
          Dividends P/S   $ 1.12, 1.19, 1.25, 1.32, 1.40, 1.45, 1.49, 1.53, 1.57, 1.61       4.1%
          Price/Earnings Ratio                                                    16.2

   800    Union Electric Co. @ 42 1/4                                                                     33,800
          Largest electric utility in Missouri
          Earnings P/S    $ 2.89, 2.91, 2.56, 2.91, 2.74, 3.01, 2.83, 2.77, 3.01, 2.95       0.2%
          Dividends P/S   $ 1.86, 1.92, 1.94, 2.02, 2.10, 2.18, 2.26, 2.34, 2.40, 2.46       3.2%
          Price/Earnings Ratio                                                    13.5
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       43

<PAGE>
                             FINANCIAL STATEMENTS

  John Hancock Funds - Institutional Series Trust -- Dividend Performers Fund
<TABLE>
<CAPTION>
                                                                                          COMPOUND
  NUMBER                                                                                   GROWTH        MARKET
OF SHARES COMMON STOCKS                                                                     RATE         VALUE
- ---------                                                                                   ----         -----

<S>       <C>                                                                               <C>       <C>

Utilities (continued)
   500    Wisconsin Energy Corp. @ 28 7/8                                                             $   14,438
          Electric and gas utility holding company
          Earnings P/S    $ 1.58, 1.70, 1.82, 1.92, 1.85, 1.87, 1.66, 1.81, 1.67, 2.13      3.0%
          Dividends P/S     $ .88, .94, 1.01, 1.09, 1.16, 1.22, 1.29, 1.34, 1.40, 1.46      5.8%
          Price/Earnings Ratio                                                    13.2
                                                                                                      ----------
                                                                                                         119,375
                                                                                                      ----------
                                                                   TOTAL COMMON STOCKS
                                                                     (Cost $2,457,888)                 2,918,706
                                                                                                      ----------

          PREFERRED STOCKS (1.73%)
   700    American Express Co. FDC, 6 1/4%
          Conv @ 58 1/2                                                                                   40,950

   500    Browing-Ferris ACES, Conv Pfd
          7.25% @ 32 5/8                                                                                  16,313
                                                                                                      ----------
                                                                TOTAL PREFERRED STOCKS
                                                                        (Cost $52,272)                    57,263
                                                                                                      ----------
</TABLE>

<TABLE>
<CAPTION>
                                                                                         PAR VALUE
SHORT-TERM INVESTMENTS                                                   INTEREST         (000'S        MARKET
(10.68%)                                                                   RATE           OMITTED)       VALUE
                                                                           ----           -------       -----

<S>                                                                        <C>            <C>         <C>
                                                                                                     
Joint Repurchase Agreement (10.58%)                                                                  
Investment in a joint repurchase agreement                                                           
  transaction with BT Securities Corp., -                                                            
  Dated 2-29-96, due 03-01-96 (secured                                                               
  by U.S. Treasury Bonds 12.50% due                                                                  
  8-15-14 and by U.S. Treasury Notes,                                                                
  6.00% - 8.25% due 8-31-97 thru                                                                     
  7-15-98) Note A                                                          5.43%             $351     $  351,000
                                                                                                      ----------
                                                                                                     
Corporate Savings Account (0.10%)                                                                    
  Investors Bank & Trust Company                                                                     
  Daily Interest Savings Account                                                                     
  Current Rate 4.75%                                                                                       3,387
                                                                                                      ----------
                                                                                                     
                                                   TOTAL SHORT-TERM INVESTMENTS            (10.68%)      354,387
                                                                                           ======     ----------
                                                              TOTAL INVESTMENTS           (100.34%)   $3,330,356
                                                                                           ======     ==========
</TABLE>

NMF No Meaningful Figure
The percentage shown for each investment category is the total value of that
category as a percentage of the net assets of the Fund.


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       44

<PAGE>
                             FINANCIAL STATEMENTS

 John Hancock Funds - Institutional Series Trust -- Dividend Performers Fund

<TABLE>

Schedule of Investments
February 29, 1996

- -------------------------------------------------------------------------------------------------------
<CAPTION>

                                                                                  PAR VALUE
                                                              INTEREST   S+P        (000's       MARKET
ISSUER, DESCRIPTION                                             RATE   RATING**    OMITTED)      VALUE
- -------------------                                             ----   --------    --------      -----

<S>                                                            <C>       <C>        <C>        <C>   
BONDS
Banks (5.07%)
 Barclays North American Capital Corp.,
  Gtd Cap Note 05-15-21                                         9.750%   AA-        $ 25       $ 29,210
 RBSG Capital Corp.,
  Gtd Cap Note 03-01-04                                        10.125    A+           25         30,110
                                                                                               --------
                                                                                                 59,320
                                                                                               --------

Broadcasting (3.61%)
 Century Communications Corp.,
  Sr Sub Deb 10-15-03                                          11.875    B+           25         27,063
 Turner Broadcasting Systems Inc.,
  Sr Note 07-01-13                                              8.375    BB+          15         15,188
                                                                                               --------
                                                                                                 42,251
                                                                                               --------

Governmental - U.S. (25.54%)
 United States Treasury,
  Bond 05-15-18                                                 9.125    AAA          25         32,211
  Bond 02-15-23                                                 7.125    AAA          20         21,210
  Note 11-15-96                                                 7.250    AAA          25         25,336
  Note 05-15-98                                                 9.000    AAA          40         42,888
  Note 11-30-99                                                 7.750    AAA         130        138,876
  Note 05-15-01                                                 8.000    AAA          35         38,456
                                                                                               --------
                                                                                                298,977
                                                                                               --------

Governmental - U.S. Agencies (16.30%)
 Financing Corp.,
  Bond Ser B 04-06-18                                           9.800    AAA          25         32,945
 Government National Mortgage Association,
  30 Yr SF Pass Thru Ctf 11-15-24                               8.000    AAA         153        157,830
                                                                                               --------
                                                                                                190,775
                                                                                               --------

Publishing (3.60%)
 News America Holding Inc.,
  Deb 08-10-18                                                  8.250    BBB          25         25,683
 Time Warner Inc.,
  Deb 01-15-13                                                  9.125    BBB-         15         16,448
                                                                                               --------
                                                                                                 42,131
                                                                                               --------

Steel (2.07%)
 Weirton Steel Corp.,
  Sr Note 06-01-05                                             10.750    B            25         24,188
                                                                                               --------

Tobacco (1.21%)
 RJR Nabisco, Inc.,
  Note 09-15-03                                                 7.625    BBB-         15         14,223
                                                                                               --------
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       45

<PAGE>

                              FINANCIAL STATEMENTS

      John Hancock Funds - Institutional Series Trust -- Active Bond Fund

<TABLE>
                                                                                                        PER VALUE
                                                                                INTEREST       S+P        (OOO'S           MARKET
ISSUER, DESCRIPTION                                                               RATE       RATING      OMITTED)          VALUE
- -------------------                                                               ----       ------      --------          -----
<S>                                                                              <C>           <C>        <C>           <C>  
Transportation (1.65%)                                                          
  United Air Lines, Inc.,                                                       
     Deb Ser B 05-01-14                                                          11.210%       BB         $   15       $   19,397
                                                                                                                       ----------
Utilities (17.55%)                                                                                                               
  BVPS II Funding Corp.,                                                        
    Collateralized Lease Bond 12-01-07                                            8.330        BB             10            9,820
  CTC Mansfield Funding Corp.,                                                  
    Sec Lease Oblig 09-30-16                                                     11.125        B+             15           15,964
  E.I.P. Refunding Corp.,                                                       
    Sec Fac Bond 10-01-12                                                        10.250        B+             25           26,502
  First PV Funding Corp.,                                                       
    Lease Oblig Ser 1986 B 01-15-16                                              10.150        B+             10           10,350
  GTE Corp.,                                                                    
    Deb 11-15-17                                                                 10.300        BBB+           25           27,871
  Hydro-Quebec (Gtd by Province of Quebec),                                     
    Deb 02-01-03                                                                  7.375        A+             25           25,999
    Deb Ser HS 02-01-21                                                           9.400        A+             10           11,914
  Iberdrola International B.V.,                                                 
    Gtd Note 06-01-03 (R)                                                         7.125        AA-            25           25,707
  Long Island Lighting Co.,                                                     
    Gen Ref Bond 05-01-21                                                         9.750        BBB-           25           25,715
  Midland Funding Corp. I,                                                      
    Sr Sec Lease Oblig Ser C 07-23-02                                            10.330        BB-            24           25,606
                                                                                                                       ----------
                                                                                                                          205,448
                                                                                                                       ----------
                                                               TOTAL BONDS      
                                                             (Cost $887,319)                              (76.60%)        896,710
                                                                                                           -----       ----------
SHORT-TERM INVESTMENTS                                                          
Joint Repurchase Agreement (22.21%)                                             
  Investment in a joint repurchase agreement transaction with B.T.              
    Securities Corp., - Dated 02-29-96, Due 03-01-96 (secured by U.S.           
    Treasury Bond, 12.50%, due 8-15-14;                                         
    and U.S. Treasury Notes, 6.00% - 8.25%, due 8-31-97 thru 7-15-98) - Note A    5.430        --            260          260,000
                                                                                                                       ----------
Corporate Savings Account (0.19%)                                               
  Investors Bank & Trust Company                                                
    Daily Interest Savings Account                                              
    Current Rate 4.75%                                                                                                      2,202
                                                                                                                       ----------
                                              TOTAL SHORT-TERM INVESTMENTS                                (22.40%)        262,202
                                                                                                           -----       ----------
                                                         TOTAL INVESTMENTS                                (99.00%)     $1,158,912
                                                                                                           =====       ==========   


NOTES TO THE SCHEDULE OF INVESTMENTS
(R) These securities are exempt from registration under Rule 144A of the Securities Act of 1933. Such securities may be resold, 
    normally to qualified institutional buyers, in transactions exempt from registration. Rule 144A securities amounted to $25,707
    as of February 29, 1996. See note A of the Notes to Financial Statements for valuation policy.
  **Credit ratings are rated by Moody's Investor Services or John Hancock Advisers, Inc. where Standard and Poors ratings are not
    available and are unaudited.
The percentage shown for each investment category is the total value of that category as a percentage of the net assets of the Fund.

</TABLE>


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       46


<PAGE>

                              FINANCIAL STATEMENTS

      John Hancock Funds - Institutional Series Trust -- Global Bond Fund

<TABLE>

Schedule of Investments
February 29, 1996
- --------------------------------------------------------------------------------


<CAPTION>

                                                              PAR VALUE
                                                  INTEREST     (000'S    MARKET
ISSUER                                              RATE      OMITTED)#   VALUE
- ------                                              ----      ---------   -----

<S>                                       <C>              <C>          <C>  
BONDS
Australia (3.61%)
  Commonwealth of
    Australia, 1-15-01                              8.75%        10     $  7,813
                                                                        --------
Canada (1.82%)                                            
  Government of Canada, 12-01-05                    8.75          5        3,944
                                                                        --------
Denmark (3.91%)                                           
  Kingdom of Denmark, 3-15-06                       8.00         47        8,484
                                                                        --------
France (6.50%)                                            
  Government of France, 10-25-05                    7.75         66       14,084
                                                                        --------
Germany (16.76%)                                          
  Federal Republic of                                     
    Germany, 1-05-06 .                              6.00         55       36,331
                                                                        --------
Italy (4.58%)                                             
  Republic of Italy, 11-01-00                      10.50     15,000        9,922
                                                                        --------
New Zealand (1.55%)                                       
  Government of                                           
    New Zealand, 7-15-98                            8.00          5        3,361
                                                                        --------
Spain (3.84%)                                             
  Government of Spain, 02-28-05                    10.00      1,010        8,316
                                                                        --------
Sweden (3.16%)                                            
  Swedish Export Credit, 06-05-01                   6.50         50        6,853
                                                                        --------
United Kingdom (6.11%)                                    
  United Kingdom                                          
    Treasury Bonds, 12-07-06                        7.50          9       13,248
                                                                        --------
United States (34.22%)                                    
  United States                                           
    Treasury Notes, 12-31-00                        5.50         16       15,830
  United States                                           
    Treasury Notes, 05-15-05##                      6.50         57       58,336
                                                                        --------
                                                                          74,166
                                                                        -------- 
                                             TOTAL BONDS  
                                          (Cost $186,537)  (86.06%)      186,522
                                                             -----      --------                                            

</TABLE>

The Schedule of Investments is a complete list of all securities owned by Global
Bond Fund on February 29, 1996. It's divided into three main categories: bonds,
options and short-term investments. The bonds are further broken down by
currency denomination. Short-term investments, which represent the Fund's "cash"
position, are listed last.
<TABLE>
<CAPTION>
                                                       EXPIRATION
CURRENCY                                CURRENCY       DATE/STRIKE       MARKET
PURCHASED                                 SOLD           PRICE            VALUE
- ---------                               --------       -----------       ------ 
<S>                            <C>                     <C>                <C> 
OPTIONS
  USD 21,000                         YEN 2,289,000     July 96/109        $128
                                                                          ----
                                     TOTAL OPTIONS
                               (Premium paid $288)       ( 0.06%)          128
                                                          -----           ----
</TABLE>

<TABLE>
<CAPTION>
                                                         PAR VALUE
                                             INTEREST      (000'S
ISSUER                                         RATE       OMITTED)#
- ------                                         ----      ---------
<S>                                            <C>       <C>          <C>    
SHORT-TERM INVESTMENTS
Joint Repurchase Agreement (11.99%)
  Investment in a joint repurchase
    agreement transaction with BT
    Securities Corp. - Dated 02-29-96,
    Due 03-01-96 (secured by U.S.
    Treasury Bond, 12.50% Due   
    08-15-14, and by U.S. Treasury Note,
    8.50% Due 04-15-97) Note A                 5.43%     $    26         26,000
                                                                       --------
               TOTAL SHORT-TERM INVESTMENTS
                             (Cost $26,000)               (11.99%)       26,000
                                                           -----       --------
                          TOTAL INVESTMENTS               (98.11%)     $212,650
                                                           =====       ========


  # Par value of foreign bonds are expressed in local currency. 
 ## A portion of this security is segregated as collateral for open forward 
    currency contracts.
USD US Dollar 
YEN Japanese Yen 
The percentage shown for each investment category is the total value of that 
category as a percentage of the net assets of the Fund.

</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       47


<PAGE>


                              FINANCIAL STATEMENTS

     John Hancock Funds - Institutional Series Trust -- Global Bond Fund

<TABLE>

Portfolio Concentration
- --------------------------------------------------------------------------------

The Fund primarily invests in bonds issued by companies and governments of other
countries. The performance of the Fund is closely tied to the economic
conditions within the countries in which it invests. The concentration of
investment by country of denomination for individual securities held by the fund
is shown in the schedule of investments. In addition, the concentration of
investments can be aggregated by various investment categories. The table below
shows the percentages of the Fund's investments at February 29, 1996 assigned to
the various investment categories.

<CAPTION>

                                                     MARKET VALUE OF SECURITIES               
INVESTMENT CATEGORIES                                   AS A % OF NET ASSETS
- ---------------------                                   --------------------

<S>                                                           <C>
Finance                                                        3.16%
Governmental - Foreign                                        48.68
Governmental - United States                                  34.22
Options                                                        0.06
Short-term Investments                                        11.99
                                                              -----
                                   TOTAL INVESTMENTS          98.11%
                                                              =====

</TABLE>

                         NOTES TO FINANCIAL STATEMENTS.
                                       48


<PAGE>

                              FINANCIAL STATEMENTS

 John Hancock Funds - Institutional Series Trust -- Multi-Sector Growth Fund

<TABLE>

Schedule of Investments
February 29, 1996
- --------------------------------------------------------------------------------

<CAPTION>

                                                           NUMBER OF    MARKET 
ISSUER, DESCRIPTION                                         SHARES       VALUE
- -------------------                                         ------       -----

<S>                                                         <C>       <C>
COMMON STOCKS 
Aerospace (2.11%)
  Wyman-Gordon Co.*                                         10,000    $  177,500
                                                                      ----------
Computers (5.48%)
  Bell & Howell Co.*                                         3,000        89,625
  Compucom Systems, Inc.*                                   10,000        73,750
  Intuit, Inc.*                                                500        33,375
  Parametric Technology Co.*                                 1,500       111,562
  Sun Microsystems, Inc.*                                    1,500        78,750
  3Com Corp.*                                                1,500        73,313
                                                                      ----------
                                                                         460,375
                                                                      ----------
Diversified Operations (4.01%)
  CUC International Inc.*                                    1,000        32,375
  Primark Corp.*                                             7,700       304,150
                                                                      ----------
                                                                         336,525
                                                                      ----------
Drugs (4.66%)
  Elan Corp. PLC (American Depositary
    Receipt) (Ireland)*                                      3,000       174,000
  Pfizer, Inc.                                               2,000       131,750
  Watson Pharmaceutical, Inc.*                               2,000        86,000
                                                                      ----------
                                                                         391,750
                                                                      ----------
Electronics (1.05%)
  Linear Technology Corp.                                    1,500        69,750
  SCI Systems, Inc.*                                           500        18,531
                                                                      ----------
                                                                          88,281
                                                                      ----------
Hazardous Waste (2.11%)
  TETRA Technologies, Inc.*                                 13,000       177,125
                                                                      ----------
Healthcare (20.42%)
  Access Health, Inc.*                                       4,000       219,000
  HBO & Co.                                                  4,000       396,000
  HealthCare COMPARE Corp.*                                  1,000        48,750
  Healthsource, Inc.*                                       10,000       378,750
  Henry Schein, Inc.*                                        3,900       113,100
  Home Health Corporation of America*                       19,000       194,750
  Johnson & Johnson                                          1,000        93,500
  Oxford Health Plans, Inc.*                                 1,500       123,469
  PhyCor, Inc.*                                              1,000        45,500
  Universal Health Services, Inc.*                           2,000       102,250
                                                                      ----------
                                                                       1,715,069
                                                                      ----------
Leisure & Recreation (0.39%)
  Walt Disney Co., (The)                                       500        32,750
                                                                      ----------

</TABLE>

The schedule of investments is a complete list of all securities owned by the
Multi-Sector Growth Fund on February 29, 1996. It's divided into two main
categories: common stocks and short-term investments. Common stocks are further
broken down by industry groups. Short-term investments, which represent the
Fund's "cash" position are listed last.

<TABLE>
<CAPTION>

                                                           NUMBER OF    MARKET 
ISSUER, DESCRIPTION                                         SHARES       VALUE
- -------------------                                         ------       -----

<S>                                                         <C>       <C>
Medical (0.90%)
  I-Stat Corp.*                                              2,000    $   76,000
                                                                      ----------
Mining (23.07%)
  Agnico-Eagle Mines Ltd.                                   11,000       185,625
  Aurora Gold Ltd. (Australia)*                             13,000        23,360
  Couer D'Alene Mines Corp.                                 11,000       259,875
  Kinross Gold Corp. (Canada)*                              31,000       286,750
  Newmont Gold Co.                                           6,000       337,500
  Prime Resource Group, Inc. (Canada)*                       4,000        38,635
  Santa Fe Pacific Gold Corp.                               16,500       257,813
  Stillwater Mining Co.*                                    11,000       242,000
  TVX Gold, Inc. (Canada)* .                                31,000       306,125
                                                                      ----------
                                                                       1,937,683
                                                                      ----------
Oil & Gas - Equipment and Services (17.73%)
  Diamond Offshore Drilling, Inc.*                           7,000       256,375
  Falcon Drilling Co., Inc.*                                17,000       344,250
  Global Marine, Inc.*                                      34,000       301,750
  Nabors Industries, Inc.* .                                14,000       180,250
  Pride Petroleum Services, Inc.*                            9,000       100,687
  Reading & Bates Corp.*                                    16,000       306,000
                                                                      ----------
                                                                       1,489,312
                                                                      ----------
Oil & Gas - Exploration and Production (13.32%)
  Cairn Energy USA, Inc.*                                   14,000       152,250
  Chesapeake Energy Corp.* .                                 8,000       331,000
  Global Natural Resources, Inc.*                            4,400        55,000
  Lomak Petroleum, Inc.                                      6,000        66,000
  Swift Energy Co.*                                          6,000        69,750
  Triton Energy Corp.*                                       4,000       198,500
  Vintage Petroleum, Inc.                                   12,000       246,000
                                                                      ----------
                                                                       1,118,500
                                                                      ----------
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       49

<PAGE>

                              FINANCIAL STATEMENTS

 John Hancock Funds - Institutional Series Trust -- Multi-Sector Growth Fund

<TABLE>
<CAPTION>

                                                          NUMBER OF     MARKET
ISSUER, DESCRIPTION                                        SHARES        VALUE
- -------------------                                        ------        -----

<S>                                                       <C>         <C>
Publishing (1.25%)
  Scholastic Corp.*                                        1,500      $  104,625
                                                                      ----------
Telecommunications (2.00%)
  U.S. Order, Inc.*                                        3,000          70,500
  United States Satellite Broadcasting Co., Inc.*          3,000          97,500
                                                                      ----------
                                                                         168,000
                                                                      ----------
                                      TOTAL COMMON STOCKS
                                        (Cost $7,307,108) (98.50%)     8,273,495
                                                           -----      ----------

<CAPTION>
                                             INTEREST     PAR VALUE
                                               RATE    (000'S OMITTED)
                                               ----    ---------------
<S>                                           <C>         <C>         <C>
SHORT-TERM INVESTMENTS
Joint Repurchase Agreement (4.54%)
      Investment in a joint repurchase
      agreement transaction with BT
      Securities Corp. - Dated 02-29-96,
      due 03-01-96 (secured by U.S.
      Treasury Bond, 12.50% due 08-15-14,
      and by U.S. Treasury Notes,
      6.00% thru 8.25% due 08-31-97
      thru 07-15-98) - Note A                  5.43%      $    381       381,000
                                                                      ----------
Corporate Savings Account (0.00%)
      Investors Bank & Trust Company
      Daily Interest Savings Account
      Current Rate 4.75%                                                     262
                                                                      ----------
                              TOTAL SHORT-TERM INVESTMENTS   (4.54%)     381,262
                                                            ------    ----------
                                         TOTAL INVESTMENTS (103.04%)  $8,654,757
                                                            ======    ==========

* Non-income producing security.
The percentage shown for each investment category is the total value of that
category as a percentage of the net assets of the Fund.

</TABLE>


Portfolio Concentration
- --------------------------------------------------------------------------------
<TABLE>

The Multi-Sector Growth Fund invests primarily in securities issued in the
United States of America. The performance of the Fund is closely tied to the
economic and financial conditions within the countries in which it invests.
The concentration of investments by industry category for individual
securities held by the Fund is shown in the Schedule of Investments. In
Addition, concentration of investments can be aggregated by various
countries. The table below shows the percentages of the Fund's investments at
February 29, 1996 assigned to country categories.
<CAPTION>

                                                              MARKET VALUE AS A
                                                                PERCENTAGE OF
COUNTRY DIVERSIFICATION                                       FUND'S NET ASSETS
- -----------------------                                       -----------------
<S>                                                               <C>
Australia                                                           0.28%
Canada                                                              7.52
Ireland                                                             2.07
United States                                                      88.63
Short-term Investments                                              4.54
                                                                  ------
                                                TOTAL INVESTMENTS 103.04%
                                                                  ======
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       50

<PAGE>

                              FINANCIAL STATEMENTS

  John Hancock Funds - Institutional Series Trust -- Fundamental Value Fund

<TABLE>

Schedule of Investments
February 29, 1996
- --------------------------------------------------------------------------------

<CAPTION>
                                                                        MARKET
ISSUER, DESCRIPTION                                NUMBER OF SHARES      VALUE
- -------------------                                ----------------      -----

<S>                                                     <C>           <C>
COMMON STOCKS                                                     
Aircraft (6.04%)                                                  
  Boeing Co. (The)                                         400        $   32,450
  Thiokol Corp.                                          7,000           287,000
                                                                      ----------
                                                                         319,450
                                                                      ----------
Auto/Truck (5.68%)                                                
  Arvin Industries Inc.                                 13,600           300,900
                                                                      ----------
Beverages (4.80%)                                                 
  Coors (Adolph) Co.                                    13,100           253,813
                                                                      ----------
Diversified Operations (9.45%)                                    
  Hanson PLC, American Depository Receipts              15,900           234,525
  Horsham Corp.                                         18,000           265,500
                                                                      ----------
                                                                         500,025
                                                                      ----------
Foods (15.05%)                                                    
  Archer-Daniels-Midland Co.                            14,515           279,414
  Dole Food Co.                                          2,300            92,575
  Morrison Restaurants Inc.                             13,000           217,750
  Savannah Foods & Inds, Inc.                           19,000           206,625
                                                                      ----------
                                                                         796,364
                                                                      ----------
Leisure & Recreation (2.95%)                                      
  Outboard Marine Corp.                                  3,600            72,900
  Russ Berrie & Co. Inc.                                 5,200            83,200
                                                                      ----------
                                                                         156,100
                                                                      ----------
Machinery (0.64%)                                                 
  Harnischfeger Industries, Inc.                           900            34,087
                                                                      ----------
Oil & Gas ( 12.17%)                                               
  Cooper Cameron Corp.*                                  9,500           308,750
  Daniel Industries, Inc.                               17,800           253,650
  Parker Drilling Co.*                                  13,600            81,600
                                                                      ----------
                                                                         644,000
                                                                      ----------
Paper (4.89%)                                                     
  Crown Vantage, Inc.*                                     130             1,950
  Glatfelter (P.H.) Co.                                 13,400           222,775
  James River Corporation of Virginia                    1,300            34,287
                                                                      ----------
                                                                         259,012
                                                                      ----------
Pollution Control (4.65%)                                         
  Calgon Carbon Corp.                                   21,900           246,375
                                                                      ----------
Publishing (0.83%)                                                
  Times Mirror Co. (The) Class A                         1,300            44,200
                                                                      ----------
</TABLE>

The schedule of investments is a complete list of all securities owned by the
Fundamental Value Fund on February 29, 1996. It's divided into two main
categories: common stocks and short-term investments. Common stocks are further
broken down by industry groups. Short-term investments, which represent the
Fund's "cash" position are listed last.


<TABLE>
<CAPTION>
                                                                        MARKET
ISSUER, DESCRIPTION                                NUMBER OF SHARES      VALUE
- -------------------                                ----------------      -----

<S>                                                     <C>           <C>
Real Estate (5.33%)                                                
  Castle & Cooke, Inc.*                                    766        $   11,394
  Tejon Ranch                                           17,200           270,900
                                                                      ----------
                                                                         282,294
                                                                      ----------
Retail (6.32%)                                                     
  Great Atlantic & Pacific Tea Co., Inc. (The)          11,600           261,000
  Ross Stores, Inc.                                      3,000            73,500
                                                                      ----------
                                                                         334,500
                                                                      ----------
Shoes (0.94%)                                                      
  Brown Group, Inc.                                      4,000            49,500
                                                                      ----------
Telecommunications (5.46%)                                         
  ANTEC Corp.*                                          16,500           288,750
                                                                      ----------
Textile (4.33%)                                                    
  Delta Woodside Industries, Inc.                        2,900            15,950
  Garan Inc.                                            14,000           213,500
                                                                      ----------
                                                                         229,450
                                                                      ----------
Transportation - Ship (4.68%)                                      
  Overseas Shipholding Group, Inc.                      13,200           247,500
                                                                      ----------
Utility - Electric Power (3.76%)                                   
  Destec Energy, Inc.*                                  17,100           198,788
                                                                      ----------
                                    TOTAL COMMON STOCKS 
                                      (Cost $4,959,504)  97.97%        5,185,108
                                                        ------        ----------
                                                                   
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       51

<PAGE>

                              FINANCIAL STATEMENTS


   John Hancock Funds - Institutional Series Trust -- Fundamental Value Fund

<TABLE>
<CAPTION>
                                        INTEREST     PAR VALUE
ISSUER, DESCRIPTION                       RATE    (000'S OMITTED)   MARKET VALUE
- -------------------                       ----    ---------------   ------------

<S>                                       <C>          <C>           <C>
SHORT-TERM INVESTMENTS
Joint Repurchase Agreement (2.29%)
   Investment in a joint repurchase 
   agreement transaction with BT 
   Securities Corp., - Dated 2-29-96, 
   due 03-01-96 (secured by U.S. 
   Treasury Bonds 12.50% due 
   8/15/14 and by U.S. Treasury Notes, 
   6.00% thru 8.25% due 8/31/97
   thru 7/15/98) - Note A                 5.43%        $121          $  121,000
                                                                     ----------
Corporate Savings Account (0.00%)
      Investors Bank & Trust Company
      Daily Interest Savings Account
      Current Rate 4.75%                                                    266
                                                                     ----------
           TOTAL SHORT-TERM INVESTMENTS   (2.29%)                       121,266
                                           ----                      ----------
                      TOTAL INVESTMENTS (100.26%)                    $5,306,374
                                         ======                      ==========



* Non-income producing security
The percentage shown for each investment category is the total value of that
category as a percentage of the net assets of the Fund.

</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       52

<PAGE>


                              FINANCIAL STATEMENTS


  John Hancock Funds - Institutional Series Trust -- International Equity Fund

<TABLE>

Schedule of Investments
February 29, 1996
- --------------------------------------------------------------------------------
<CAPTION>

                                                            NUMBER OF    MARKET
ISSUER, DESCRIPTION                                          SHARES       VALUE
- -------------------                                          ------       -----

<S>                                                         <C>         <C>
COMMON STOCKS
Australia (5.09%)
  Broken Hill Proprietary Co., Ltd. 
    (Diversified Operations) .                                1,210   $   17,529
  News Corp. Ltd. (The) (Publishing)                          3,100       17,632
  Plutonic Resources Ltd. 
    (Gold Mining & Products) .                               20,000      112,377
                                                                      ----------
                                                                         147,538
                                                                      ----------
Brazil (1.09%)
  Telecomunicacoes Brasileiras S/A.,
    American Depositary Receipts (ADR)
    (Telecommunications)                                        600       31,500
                                                                      ----------
Chile (0.85%)
  Santa Isabel S.A., (ADR) (Retail)*                          1,000       24,625
                                                                      ----------
Denmark (1.62%)
  Tele Danmark AS (Telecommunications)                          800       47,027
                                                                      ----------
France (4.48%)
  Banque Nationale de Paris (Banks)                             280       10,834
  Carrefour SA (Retail)                                         100       67,524
  LVMH Moet Henessey Louis Vuitton
    (Beverages)                                                 225       51,253
                                                                      ----------
                                                                         129,611
                                                                      ----------
Germany (3.19%)
  Bayer AG (Chemicals)                                          150       45,759
  Mannesmann AG (Diversified Operations)                        130       46,466
                                                                      ----------
                                                                          92,225
                                                                      ----------
Hong Kong (15.00%)
  Cheung Kong (Holdings) Ltd. (Real Estate)                  11,000       76,479
  CITIC Pacific Ltd. (Diversified Operations)                12,000       46,722
  HSBC Holdings Ltd. (Banks)                                  3,400       54,534
  Hutchison Whampoa Ltd. 
    (Diversified Operations) .                               10,000       63,382
  Joyce Boutique Holdings Ltd. (Retail)                     250,000       89,737
  Swire Pacific Ltd. (Diversified Operations)                 7,000       61,118
  Wharf (Holdings) Ltd. (Diversified Operations)             11,000       42,615
                                                                      ----------
                                                                         434,587
                                                                      ----------
Japan (27.96%)
  Bridgestone Corp. (Auto/Truck)                              4,000       62,420
  Daido Steel Co., Ltd. (Steel)                               3,000       15,329
  Denki Kagaku Kogyo K.K. (Chemicals)*                        4,000       16,024
  Fanuc Ltd. (Machinery)                                      2,000       86,779
  Fujisawa Pharmaceutical Co., Ltd. (Drugs)                   3,000       28,546

</TABLE>

The Schedule of Investments is a complete list of all securities owned by the
International Equity Fund on February 29, 1996. It's divided into two main
categories: common stocks and short-term investments. Common stocks are further
broken down by country. Under each country heading is a list of the securities
owned by the Fund. Short-term inve stments, which represent the Fund's "cash"
position, are listed last. Number of Market

<TABLE>
<CAPTION>
                                                            NUMBER OF    MARKET
ISSUER, DESCRIPTION                                          SHARES       VALUE
- -------------------                                          ------       -----
<S>                                                          <C>      <C>
Japan (continued)
  Itochu Corp. (Diversified Operations)                      10,000   $   66,987
  Jusco Co., Ltd. (Retail) .                                  2,000       50,240
  Matsushita Electric Industrial Co., Ltd. 
    (Electronics)                                             5,000       79,928
  Matsushita-Kotobuki Electronics Industries,
    Ltd. (Electronics)                                        2,000       50,431
  NKK Corp. (Steel)*                                          6,000       16,671
  Nippon Television Network Corp. 
    (Broadcasting)                                              200       57,091
  Oki Electric Industry Co., Ltd. 
    (Telecommunications)*                                     4,000       34,749
  Rohm Co., Ltd. (Electronics)                                  400       23,788
  Sanwa Bank, Ltd. (Banks) .                                  2,000       36,729
  Seino Transportation Co., Ltd. (Transportation)             1,000       16,652
  Sony Corp. (Electronics) .                                    700       41,030
  Sony Music Entertainment Inc. (Electronics)                 1,000       49,669
  Sumitomo Osaka Cement Co., Ltd. 
    (Building Products)                                       3,000       14,016
  Sumitomo Trust & Banking Co., Ltd. 
    (The) (Banks)                                             1,000       12,465
  TDK Corp. (Electronics)                                     1,000       50,431
                                                                      ----------
                                                                         809,975
                                                                      ----------
Malaysia (1.16%)
  Resorts World Berhad (Leisure & Recreation)                 6,000       33,669
                                                                      ----------
Mexico (1.37%)
  Telefonos de Mexico S.A. de C.V. (ADR)
    (Telecommunications)                                      1,300       39,650
                                                                      ----------
Netherlands (2.63%)
  Koninklijke P.T.T. Nederland
    (Telecommunications)                                        425       17,064
  Polygram N.V. (Audio/Video)                                 1,015       59,187
                                                                      ----------
                                                                          76,251
                                                                      ----------
</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.             
                                       53

<PAGE>



                              FINANCIAL STATEMENTS


  John Hancock Funds - Institutional Series Trust -- International Equity Fund

<TABLE>
<CAPTION>                                                            
                                                       NUMBER OF       MARKET
ISSUER, DESCRIPTION                                      SHARES         VALUE
- -------------------                                      ------         -----
<S>                                                      <C>          <C>       
New Zealand (2.52%)
  Carter Holt Harvey Ltd. (Paper)                        15,300       $   32,750
  Telecom Corporation of New Zealand
    (Telecommunications)                                  9,000           40,347
                                                                      ----------
                                                                          73,097
                                                                      ----------
Norway (3.68%)
  Den norske Bank AS (Banks)                              5,500           17,868
  Hafslund Nycomed (Drugs) .                              2,000           54,821
  Orkla AS (Diversified Operations)                         750           33,971
                                                                      ----------
                                                                         106,660
                                                                      ----------
Singapore (3.34%)
  Fraser & Neave Ltd. (Diversified Operations)            2,000           26,771
  Jardine Matheson Holdings Ltd. 
    (Diversified Operations) .                            2,400           19,200
  Keppel Corp. (Diversified Operations)                   5,000           50,637
                                                                      ----------
                                                                          96,608
                                                                      ----------
Spain (0.63%)
  Repsol SA (Oil & Gas)                                     500           18,262
                                                                      ----------
Sweden (3.37%)
  Atlas Copco AB (Machinery)                              1,000           17,327
  Investor AB (Diversified Operations)                    1,550           58,305
  Telefonaktiebolaget (LM) Ericsson
    (Telecommunications)                                  1,012           21,956
                                                                      ----------
                                                                          97,588
                                                                      ----------
Switzerland (2.51%)
  BBC Brown Boveri AG (Engineering)                          80           18,817
  Ciba-Geigy AG (Drugs)                                      42           37,519
  Nestle S.A. (Food)                                         15           16,415
                                                                      ----------
                                                                          72,751
                                                                      ----------
United Kingdom (13.26%)
  British Petroleum Co. PLC (Oil & Gas)                  10,000           82,746
  Carlton Communications PLC (Broadcasting)               2,500           16,022
  Dixons Group PLC (Retail)                              11,300           80,170
  Glaxo Welcome PLC (Drugs)                               2,700           37,360
  National Westminster Bank PLC (Banks)                   8,000           84,769
  Reed International PLC (Publishing)                     2,670           42,038
  Thorn EMI PLC (Leisure & Recreation)                    1,640           40,887
                                                                      ----------
                                                                         383,992
                                                                      ----------
                                     TOTAL COMMON STOCKS
                                       (Cost $2,547,128) (93.75%)      2,715,616
                                                          -----       ----------
</TABLE>

<TABLE>

                                            INTEREST    PAR VALUE      MARKET
ISSUER, DESCRIPTION                           RATE    (000'S OMITTED)   VALUE
- -------------------                           ----    ---------------   -----

<S>                                          <C>           <C>        <C>
SHORT-TERM INVESTMENTS
Joint Repurchase Agreement (6.56%)
      Investment in a joint repurchase
      agreement transaction with BT
      Securities Corp. - Dated 02-29-96,
      Due 03-01-96 (secured by U.S.
      Treasury Bond, 12.50% Due 08-15-14
      and by U.S. Treasury Note, 8.50%
      Due 04-15-97) - Note A                 5.43%         $190       $  190,000
                                                                      ----------
                           TOTAL SHORT-TERM INVESTMENTS   (6.56%)        190,000
                                                           ----       ----------
                                      TOTAL INVESTMENTS (100.31%)     $2,905,616
                                                         ======       ==========
</TABLE>

*Non-income producing security.
The percentage shown for each investment category is the total value of that
category as a percentage of the net assets of the Fund. 


                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       54

<PAGE>




                              FINANCIAL STATEMENTS


  John Hancock Funds - Institutional Series Trust -- International Equity Fund

<TABLE>

Portfolio Concentration
- --------------------------------------------------------------------------------

The Fund primarily invests in securities issued by companies of other countries.
The performance of the Fund is closely tied to the economic conditions within
the countries it invests. The concentration of investments by country for
individual securities held by the Fund is shown in the schedule of investments.
In addition, the concentration of investments can be aggregated by various
industry groups. The table below shows the percentages of the Fund's Investments
at February 29, 1996 assigned to the various investment categories.

<CAPTION>


                                                      MARKET VALUE OF SECURITIES
INVESTMENT CATEGORIES                                    AS A % OF NET ASSETS
- ---------------------                                    --------------------
<S>                                                            <C>
Audio/Video                                                     2.04%
Automobile/Trucks                                               2.16
Banks                                                           7.50
Beverages                                                       1.77
Broadcasting                                                    2.52
Building Products                                               0.48
Chemicals                                                       2.13
Diversified Operations                                         18.43
Drugs                                                           5.46
Electronics                                                    10.19
Engineering                                                     0.65
Food                                                            0.57
Gold Mining & Products                                          3.88
Leisure & Recreation                                            2.57
Machinery                                                       3.59
Oil & Gas                                                       3.49
Paper                                                           1.13
Publishing                                                      2.06
Real Estate                                                     2.64
Retail                                                         10.78
Steel                                                           1.11
Telecommunications                                              8.02
Transportation                                                  0.58
Short-Term Investments                                          6.56
                                                              ------ 
                        TOTAL INVESTMENTS                     100.31%
                                                              ======

</TABLE>

                       SEE NOTES TO FINANCIAL STATEMENTS.
                                       55

<PAGE>


                          NOTES OF FINANCIAL STATEMENTS

                 John Hancock Funds - Institutional Series Trust


NOTE A --                             
ACCOUNTING POLICIES 

John Hancock Dividend Performers Fund ("Dividend Performers Fund"), John Hancock
Active Bond Fund ("Active Bond Fund"), John Hancock Global Bond Fund ("Global
Bond Fund"), John Hancock Multi-Sector Growth Fund ("Multi-Sector Growth Fund"),
John Hancock Fundamental Value Fund ("Fundamental Value Fund") and John Hancock
International Equity Fund ("International Equity Fund"), (each, a "Fund" and
collectively, the "Funds"), are separate portfolios of John Hancock
Institutional Series Trust (the "Trust"), an open-end management investment
company, registered under the Investment Company Act of 1940. Prior to September
12, 1995, Dividend Performers Fund was known as John Hancock Berkeley Dividend
Performers Fund, Active Bond Fund was known as John Hancock Berkeley Bond Fund,
Global Bond Fund was known as John Hancock Berkeley Global Bond Fund,
Multi-Sector Growth Fund was known as John Hancock Berkeley Sector Opportunity
Fund, Fundamental Value Fund was known as John Hancock Berkeley Fundamental
Value Fund and International Equity Fund was known as John Hancock Berkeley
Overseas Growth Fund. The Trust, organized as a Massachusetts business trust in
1994, consists of twelve series portfolios: the Funds, John Hancock Small
Capitalization Equity Fund, John Hancock Independence Balanced Fund, John
Hancock Independence Diversified Core Equity Fund II, John Hancock Independence
Growth Fund, John Hancock Independence Medium Capitalization Fund and John
Hancock Independence Value Fund. Each Fund currently has one class of shares
with equal rights as to voting, redemption, dividends and liquidation within
their respective Fund. The Trustees may authorize the creation of additional
portfolios from time to time to satisfy various investment objectives.

     The investment objective of the Dividend Performers Fund is long-term
growth of capital and of income without assuming undue market risk. The
investment objective of the Active Bond Fund is a high level of current income,
consistent with prudent investment risk, through investment primarily in a
diversified portfolio of freely marketable investment grade debt securities of
U.S. and foreign issuers. The investment objective of the Global Bond Fund is a
competitive total investment return, consisting of curre nt income and capital
appreciation. The investment objective of the Multi-Sector Growth Fund is
long-term capital appreciation. The investment objective of the Fundamental
Value Fund is capital appreciation with income as a secondary consideration. The
investment objective of the International Equity Fund is long-term growth of
capital.

     Significant accounting policies of the Funds are as follows:

VALUATION OF INVESTMENTS Securities in the Funds portfolios are valued on the
basis of market quotations, valuations provided by independent pricing services
or, at fair value as determined in good faith in accordance with procedures
approved by the Trustees. Short-term debt investments maturing within 60 days
are valued at amortized cost which approximates market value. All portfolio
transactions initially expressed in terms of foreign currencies have been
translated into U.S. dollars as described in "Foreign Currency Translation"
below.

JOINT REPURCHASE AGREEMENT Pursuant to an exemptive order issued by the
Securities and Exchange Commission, the Funds, along with other registered
investment companies having a management contract with John Hancock Advisers,
Inc. (the "Adviser"), a wholly-owned subsidiary of The Berkeley Financial Group,
may participate in a joint repurchase agreement transaction. Aggregate cash
balances are invested in one or more repurchase agreements, whose underlying
securities are obligations of the U.S. government and/or its agencies. The
Fund's custodian bank receives delivery of the underlying securities for the
joint account on the Fund's behalf. The Adviser is responsible for ensuring that
the agreement is fully collateralized at all times.

INVESTMENT TRANSACTIONS Investment transactions are recorded as of the date of 
purchase, sale or maturity. Net realized gains and losses on sales of
investments are determined on the identified cost basis. Capital gains realized
on some foreign securities are subject to foreign taxes and are accrued, as
applicable. 

FEDERAL INCOME TAXES The Fund's policy is to comply with the requirements of the
Internal Revenue Code that are applicable to regulated investment companies.
They will not be subject to federal income tax on taxable earnings which are
distributed to shareholders.


                                       56


<PAGE>


                          NOTES OF FINANCIAL STATEMENTS

                  John Hancock Funds - Institutional Series Trust

For federal income tax purposes, net currency exchange gains and losses from
sales of foreign debt securities may be treated as ordinary income even though
such items are gains and losses for accounting purposes. For federal income tax
purposes and to the extent provided by regulations, to offset future net
realized capital gains, the Fundamental Value Fund has a capital loss
carryforward available of $230 expiring February 28, 2004. To the extent that
such carryforwards are used by the Funds, no capital gain dist ribution will be
made. Expired capital loss carryforwards are reclassified to capital paid-in, in
the year of expiration. Additionally, net capital losses for the International
Equity Fund of $6,781 and net foreign currency losses for the Global Bond Fund
of $1,367 attributable to security transactions occurring after October 31, 1995
are treated as arising on the first day (March 1, 1996) of the Funds next
taxable year.

DIVIDENDS, DISTRIBUTIONS AND INTEREST Dividend income on investment securities
is recorded on the ex-dividend date or, in the case of some foreign securities,
on the date thereafter when the Funds are made aware of the dividend. Interest
income on investment securities is recorded on the accr ual basis. Foreign
income may be subject to foreign withholding taxes which are accrued as
applicable.

     The Funds record all distributions to shareholders from net investment
income and realized gains on the ex-dividend date. Such distributions are
determined in conformity with income tax regulations, which may differ from
generally accepted accounting principles.

EXPENSES The majority of the expenses of the Trust are directly identifiable to
an individual Fund. Expenses which are not readily identifiable to a specific
Fund are allocated in such a manner as deemed equitable, taking into
consideration, among other things, the nature and type of expense and the
relative sizes of the Funds.

ORGANIZATION EXPENSE Expenses incurred in connection with the organization of
the Funds have been capitalized and are being charged to the Funds operations
ratably over a five-year period that began with the commencement of investment
operations of the Funds.

     In the event that any of the initial shares are redeemed during the
amortization period, the redemption proceeds will be reduced by a pro rata
portion of the then unamortized organization expense in the same proportion as
the number of the initial shares redeemed bears to the number of the initial
shares outstanding at the time of such redemption.

USE OF ESTIMATES The preparation of these financial statements in accordance
with generally accepted accounting principles incorporates estimates made by
management in determining the reported amounts of assets, liabilities, revenues,
and expenses of the Fund. 

DISCOUNT ON SECURITIES The Funds accrete discount from par value on securities
from either the date of issue or the date of purchase over the life of the
security, as required by the Internal Revenue Code.

FOREIGN CURRENCY TRANSLATION All assets or liabilities initially expressed in
terms of foreign currencies are translated into U.S. dollars based on London
currency exchange quotations as of 5:00 p.m., London time, on the date of any
determination of the net asset value of the Funds. Transactions affecting
statement of operations accounts and net realized gain/loss on investments are
translated at the rates prevailing at the dates of the transactions.

     The Fund does not isolate that portion of the results of operations
resulting from changes in foreign exchange rates on investments from the
fluctuations arising from changes in market prices of securities held. Such
fluctuations are included with the net realized and unrealized gain or loss from
investments. 

     Reported net realized foreign exchange gains or losses arise from sales of
foreign currency, currency gains or losses realized between the trade and
settlement dates on securities transactions and the difference between the
amounts of dividends, interest, and foreign withholding taxes recorded on the
Fund's books and the U.S. dollar equivalent of the amounts actually received or
paid. Net unrealized foreign exchange gains and losses arise from changes in the
value of assets and liabilities other than investmen ts in securities, resulting
from changes in the exchange rate.

FORWARD FOREIGN CURRENCY EXCHANGE CONTRACTS The Funds, other than Dividend
Performers Fund, may enter into forward foreign currency exchange contracts as a
hedge against the effect of fluctuations in currency exchange rates. A forward
foreign currency exchange contract involves an obligation to purchase or sell a
specific currency


                                       57


<PAGE>


                          NOTES OF FINANCIAL STATEMENTS

                 John Hancock Funds - Institutional Series Trust


at a future date at a set price. The aggregate principal amounts of the
contracts are marked-to-market daily at the applicable foreign currency exchange
rates. Any resulting unrealized gains and losses are included in the
determination of the Fund's daily net assets. The Funds record realized gains
and losses at the time the forward foreign currency contract is closed out or
offset by a matching contract. Risks may arise upon entering these contracts
from potential inability of counterparties to meet the terms of the contract and
from unanticipated movements in the value of a foreign currency relative to the
U.S. dollar.

     These contracts involve market or credit risk in excess of the unrealized
gain or loss reflected in the Fund's Statement of Assets and Liabilities. The
Funds may also purchase and sell forward contracts to facilitate the settlement
of foreign currency denominated portfolio transactions, under which it intends
to take delivery of the foreign currency. Such contracts normally involve no
market risk other than that offset by the currency amount of the underlying
transaction.
<TABLE>

     Open foreign currency forward sell contracts at February 29, 1996 for
Global Bond Fund were as follows:
<CAPTION>

                   PRINCIPAL AMOUNT   EXPIRATION   UNREALIZED APPRECIATION/
CURRENCY:        COVERED BY CONTRACT     MONTH         (DEPRECIATION)
- ---------        -------------------     -----         --------------
<S>                       <C>            <C>                <C> 
GERMAN MARK               47,000         APR 96             $ 1
FRENCH FRANK              49,418         APR 96              (1)
BRITISH POUND              7,000         MAR 96             $67
                                                            ---
                                                            $67
                                                            ===
</TABLE>

<TABLE> 
     Open foreign currency forward buy contracts at February 29, 1996 for Global
Bond Fund were as follows:
<CAPTION>

                   PRINCIPAL AMOUNT   EXPIRATION   UNREALIZED APPRECIATION/
CURRENCY:        COVERED BY CONTRACT     MONTH         (DEPRECIATION)
- ---------        -------------------     -----         --------------
<S>                     <C>              <C>                <C> 
JAPANESE YEN              417,532        MAR 96             ($25)
JAPANESE YEN            3,147,940        APR 96             (293)
                                                            ----
                                                           ($318)
                                                            ====

</TABLE>

     There were no open forward currency exchange contracts at February 29, 1996
for all other Funds.

OPTIONS Listed options will be valued at the last quoted sales price on the
exchange on which they are primarily traded. Purchased put or call
over-the-counter options will be valued at the average of the "bid" prices
obtained from two independent brokers. Written put or call over-the-counter
options will be valued at the average of the "asked" prices obtained from two
independent brokers. Upon the writing of a call or put option, an amount equal
to the premium received by the Fund will be included in the Statement of Assets
and Liabilities as an asset and corresponding liability. The amount of the
liability will be subsequently marked-to-market to reflect the current market
value of the written option.

     The Funds may use option contracts to manage its exposure to the stock
market and currency interest rates. Writing puts and buying calls will tend to
increase the Fund's exposure to the underlying instrument and buying puts and
writing calls will tend to decrease the Fund's exposure to the underlying
instrument, or hedge other Fund investments.

     The maximum exposure to loss for any purchased options will be limited to
the premium initially paid for the option. In all other cases, the face (or
"notional") amount of each contract at value will reflect the maximum exposure
of the Fund in these contracts, but the actual exposure will be limited to the
change in value of the contract over the period the contract remains open.

     Risks may also arise if counterparties do not perform under the contract's
terms, or if the Fund is unable to offset a contract with a counterparty on a
timely basis ("liquidity risk"). Exchange-traded options have minimal credit
risk as the exchanges act as counterparties to each transaction, and only
present liquidity risk in highly unusual market conditions. To minimize credit
and liquidity risks in over-the-counter option contracts, the Fund will
continuously monitor the creditworthiness of all its counterparties.

     At any particular time, except for purchased options, market or credit risk
may involve amounts in excess of those reflected in the Fund's period-end
Statement of Assets and Liabilities.

     There were no written option transactions for the period ended February 29,
1996 for all Funds.


                                       58

<PAGE>



                          NOTES OF FINANCIAL STATEMENTS

                 John Hancock Funds - Institutional Series Trust


NOTE B --                             
MANAGEMENT FEE, AND
TRANSACTIONS WITH AFFILIATES AND OTHERS

Under the present investment management contract, each Fund pays a monthly
management fee to the Adviser, for a continuous investment program equivalent,
on an annual basis as follows:

            FUND                                 RATE
            ----                                 ----
Dividend Performers Fund    .60% of average daily net assets up to $500 million
                            .55% of such assets in excess of $500 million

Active Bond Fund            .50% of average daily net assets up to $1.5 billion 
                            .45% of such assets in excess of $1.5 billion

Global Bond Fund            .75% of average daily net assets up to $250 million 
                            .70% of such assets in excess of $250 million

Multi-Sector Growth Fund    .80% of average daily net assets up to $500 million
                            .75% of such assets in excess of $500 million

Fundamental Value Fund      .70% of average daily net assets up to $500 million
                            .65% of such assets in excess of $500 million

International Equity Fund   .90% of average daily net assets up to $500 million
                            (.95% prior to September 12, 1995)
                            .65% of such assets in excess of $500 million

     In the event normal operating expenses of the Funds, exclusive of certain
expenses prescribed by state law, are in excess of the most restrictive state
limit where the Funds are registered to sell shares of beneficial interest, the
fees payable to the Adviser will be reduced to the extent of such excess, and
the Adviser will make additional arrangements necessary to eliminate any
remaining excess expenses. The current limits are 2.5% of the first $30,000,000
of the Fund's average daily net assets, 2.0% of the next $70,000,000 and 1.5% of
the remaining average daily net asset value.

     Prior to September 12, 1995, the Adviser agreed to limit the Funds
expenses, including the management fee, to the extent required to prevent
expenses from exceeding: 0.80% of Dividend Performers Fund's average daily net
assets, 0.70% of Active Bond Fund's average daily net assets, 1.10% of Global
Bond Fund's average daily net assets, 1.00% of Multi-Sector Growth Fund's
average daily net assets, 0.95% of Fundamental Value Fund's average daily net
assets and 1.15% of International Equity Fund's average daily net assets.

     Effective September 12, 1995, the Adviser agreed to limit the Funds
expenses further to the extent required to prevent expenses from exceeding:
0.70% of Dividend Performers Fund's average daily net assets, 0.60% of Active
Bond Fund's average daily net assets, 0.85% of Global Bond Fund's average daily
net assets, 0.90% of Multi-Sector Growth Fund's average daily net assets, 0.80%
of Fundamental Value Fund's average daily net assets and 1.00% of International
Equity Fund's average daily net assets. The Adviser reserves the right to
terminate this limitation in the future. Accordingly, for the period ended
February 29, 1996, the reduction in the Fund's expenses with any additional
amounts not borne by the Funds by virtue of the expense limit amounted to
$82,775 for Dividend Performers Fund, $79,799 for Active Bond Fund, $79,439 for
Global Bond Fund, $92,922 for Multi-Sector Growth Fund, $83,656 for Fundamental
Value Fund and $92,015 for International Equity Fund.

     Sovereign Asset Management Corp. ("SAMCorp"), serves as subadviser to
Dividend Performers Fund pursuant to a subadvisory agreement with that Fund and
the Adviser. SAMCorp was organized in 1992 and is an indirect wholly-owned
subsidiary of the John Hancock Mutual Life Insurance Company. The Adviser pays
SAMCorp a monthly management fee, equivalent on an annual basis, to the sum of
(a) 20% of the advisory fee payable on the Fund's average daily net assets up to
$100 million and (b) 55% of the advisory fee payable on the Fund's assets
exceeding $100 million.

     NM Capital Management, Inc. ("NM Capital"), serves as subadviser to
Fundamental Value Fund pursuant to a subadvisory agreement with that Fund and
the Adviser. NM Capital was organized in 1977 and is an indirect wholly-owned
subsidiary of the John Hancock Mutual Life Insurance Company. The Adviser pays
NM Capital a monthly management fee, equivalent on an annual basis, to the sum
of (a) 20% of the advisory fee payable on the Fund's average daily net assets up
to $100 million and (b) 55% of the advisory fee payable on the Fund's assets
exceeding $100 million.

     John Hancock Advisers International, Ltd. serves as subadviser to
International Equity Fund pursuant to a subadvisory agreement with that Fund and
the Adviser. Formed in 1987, it is a wholly-owned

                                       59


<PAGE>


                          NOTES OF FINANCIAL STATEMENTS

                 John Hancock Funds - Institutional Series Trust


subsidiary of the Adviser. The Adviser pays John Hancock Advisers International,
Ltd. a monthly management fee, equivalent on an annual basis, to the sum of (a)
70% of the advisory fee payable on the Fund's average daily net assets up to
$500 million and (b) 90% of the advisory fee payable on the Fund's assets
exceeding $500 million.

     The Funds are not responsible for payment of these subadvisory fees. 

     The Funds have a distribution agreement with John Hancock Funds, Inc. ("JH
Funds"), a wholly-owned subsidiary of the Adviser. For the period ended February
29, 1996, all sales of shares of beneficial interest were sold at net asset
value. The Funds pay all expenses of printing prospectuses and other sales
literature, all fees and expenses in connection with qualification as a dealer
in various states, and all other expenses in connection with the sale and
offering for sale of the shares of the Fund which have not been herein
specifically allocated to the Trust.

     The Funds have a transfer agent agreement with John Hancock Investor
Services Corporation ("Investor Services"), a wholly-owned subsidiary of The
Berkeley Financial Group. Each fund pays Investor Services an annual fee accrued
daily of 0.05% of its average daily net assets, plus certain out-of-pocket
expenses.

     On March 26, 1996, the Board of Trustees approved retroactively to January
1, 1996, an agreement with the Adviser to perform necessary tax and financial
management services for the Funds. The compensation for 1996 is estimated to be
at annual rate of 0.01875% of the average net assets of each Fund.

     Messrs. Edward J. Boudreau, Jr., Richard S. Scipione and Thomas W.L.
Cameron are directors and/or officers of the Adviser, and/or its affiliates as
well as Trustees of the Fund. The Adviser and other subsidiaries of John Hancock
Mutual Life Insurance Company owned 635,416 shares of beneficial interest of
Multi-Sector Growth Fund as of February 29, 1996. The compensation of
unaffiliated Trustees is borne by the Funds.


NOTE C --
INVESTMENT TRANSACTIONS
<TABLE>

Cost of purchases and proceeds from sales of securities, excluding short term
obligations, for the period ended February 29, 1996 were as follows:
<CAPTION>

                                                 PURCHASES               SALES
                                                 ---------               -----
<S>                                             <C>                   <C>
Dividend Performers Fund
  U.S. Government Securities                    $   201,250           $  201,000
  Other Investments                               3,768,396            1,302,342
Active Bond Fund
  U.S. Government Securities                        644,083              178,788
  Other Investments                                 588,061              169,520
Global Bond Fund
  U.S. Government Securities                        115,165               42,790
  Other Investments                                 207,174               94,302
Multi-Sector Growth Fund .                       14,222,604            7,015,710
Fundamental Value Fund                            4,962,327                2,593
International Equity Fund                         3,218,007              665,907

</TABLE>
<TABLE>

     At February 29, 1996, the cost (excluding the corporate savings account)
and gross unrealized appreciation and depreciation in value of investments owned
by the Funds, as computed on a federal income tax basis, were as follows:
<CAPTION>

                                                                  NET UNREALIZED
                     AGGREGATE  GROSS UNREALIZED GROSS UNREALIZED  APPRECIATION/
                       COST      APPRECIATION      DEPRECIATION     EPRECIATION)
                       ----      ------------      ------------     ------------
<S>                 <C>           <C>               <C>               <C>
Dividend
  Performers Fund   $2,865,116    $  473,890        ($  12,037)       $461,853
Active Bond Fund     1,147,319        13,019        (    3,628)          9,391
Global Bond Fund       212,537         1,419        (    1,434)            (15)
Multi-Sector
  Growth Fund        7,698,896     1,094,586        (  138,987)        955,599
Fundamental
  Value Fund         5,080,504       493,136        (  267,532)        225,604
International
  Equity Fund        2,737,128       201,544        (   33,056)        168,488

</TABLE>


                                       60


<PAGE>



                          NOTES OF FINANCIAL STATEMENTS

                 John Hancock Funds - Institutional Series Trust


NOTE D --
RECLASSIFICATION OF CAPITAL ACCOUNTS

During the period ended February 29, 1996, the Global Bond Fund has reclassified
amounts to reflect a decrease in undistributed net investment income of $616, an
increase in accumulated net realized loss on investments of $1,657 and a
decrease in capital paid-in of $1,041. The Multi-Sector Growth Fund has
reclassified amounts to reflect a decrease in accumulated net realized gain on
investments and accumulated net investment loss on investments of $3,720. The
International Equity Fund has reclassified amounts to reflect a decrease in
accumulated net realized loss on investments and undistributed net investment
income of $2,565. These represent the cumulative amounts necessary to report
these balances on a tax basis, excluding certain temporary differences, as of
February 29, 1996. Additional adjustments may be needed in subsequent reporting
periods. These reclassifications, which have no impact on the net asset value of
the Fund, are primarily attributable to certain differences in the computation
of distributable income and capital gains under federal tax rules versus
generally accepted accounting principles.


                                       61


<PAGE>

                 John Hancock Funds - Institutional Series Trust


INDEPENDENT AUDITORS' REPORT 

To the Shareholders and Trustees 
John Hancock Institutional Series Trust 

We have audited the accompanying statements of assets and liabilities, including
the schedules of investments, of John Hancock Institutional Series Trust
(comprised of John Hancock Dividend Performers Fund, John Hancock Active Bond
Fund, John Hancock Global Bond Fund, John Hancock Multi-Sector Growth Fund, John
Hancock Fundamental Value Fund and John Hancock International Equity Fund,
respectively) (The "Funds") as of February 29, 1996, and the related statements
of operations, the statements of changes in net assets and the financial
highlights for the period ended February 29, 1996. These financial statements
and financial highlights are the responsibility of the Fund's management. Our
responsibility is to express an opinion on these financial statements and
financial highlights based on our audits.

     We conducted our audits in accordance with generally accepted auditing
standards. Those standards require that we plan and perform the audit to obtain
reasonable assurance about whether the financial statements and financial
highlights are free of material misstatement. An audit includes examining, on a
test basis, evidence supporting the amounts and disclosures in the financial
statements. Our procedures included confirmation of securities owned at February
29, 1996 by correspondence with the custodian and brokers, where replies were
not received from brokers, we performed other auditing procedures. An audit also
includes assessing the accounting principles used and significant estimates made
by management, as well as evaluating the overall financial statement
presentation. We believe that our audits provide a reasonable basis for our
opinion.

     In our opinion, such financial statements and financial highlights present
fairly, in all material respects, the financial position of each of the
respective Funds constituting John Hancock Institutional Series Trust at
February 29, 1996, the results of their operations, the changes in their net
assets, and their financial highlights for each of the periods then ended in
conformity with generally accepted accounting principles.

Deloitte & Touche LLP
Boston, Massachusetts
April 10, 1996

TAX INFORMATION NOTICE (UNAUDITED)

For Federal income tax purposes, the following information is furnished with
respect to the distributions of the Fund for its fiscal year ended February 29,
1996.

     Shareholders will receive a 1996 U.S. Treasury Department Form 1099-DIV in
January of 1997. This will reflect the total of all distributions which are
taxable for the calendar year 1996.

     For the fiscal year ending February 29, 1996, the Dividend Performers Fund
had 45% of the ordinary income distributions qualify for the dividends received
deductions, the Multi-Sector Growth Fund had 5% of the ordinary income
distributions qualify for the dividends received deductions, the Fundamental
Value Fund had 82% of the ordinary income distributions qualify for the
dividends received deductions and the International Equity Fund had 7% of the
ordinary income distributions qualify for the dividends received deductions.


                                       62


<PAGE>


                 John Hancock Funds Institutional Series Trust

Dividend Increases (Unaudited) 

Listed below are the most recent dividend increases for the common stocks held
in Dividend Performers Fund as of February 29,1996.

                                                           PERCENT OF
COMPANY                                                DIVIDEND INCREASE
- -------                                                -----------------
Abbott Laboratories ............................             10.5%
AFLAC ..........................................             13.0
Air Products ...................................              6.1
Albertson's ....................................             18.2
Alco Standard ..................................              7.7
ALLTEL Corp. ...................................              8.3
American Home Products .........................              2.7
American International Group ...................             10.8
AMP, Inc. ......................................              9.5
Archer Daniels Midland .........................            110.1
Automatic Data Processing, Inc. ................             14.3
BankOne ........................................              9.7
Bemis, Inc. ....................................             18.5
Campbell's .....................................             11.3
Central and SouthWest ..........................              1.2
Chubb ..........................................              6.5
Corning, Inc. ..................................              5.9
CPC International ..............................              5.6
CSX Corp. ......................................             18.1
E.I. DuPont De Nemours & Co., Inc. .............             10.6
Emerson Electric ...............................             14.0
Exxon ..........................................              4.2
Federal Signal Corp. ...........................             19.0
First Tennessee National Corp. .................             12.8
Florida Progress Corp. .........................              2.0
Frontier Corp. .................................              2.4
Gannett ........................................              2.9
General Electric ...............................             12.2
General Motors, Cl E ...........................              8.3
Heinz ..........................................             10.4
Interpublic Group ..............................             10.7
Johnson & Johnson ..............................             13.8
KeyCorp ........................................             12.5
Kimberly Clark .................................              3.0
Leggett & Platt ................................             11.1
Lowe's Department Stores .......................             11.1
May Department Stores ..........................              9.6
McDonald's .....................................             12.5
Merck ..........................................             13.3
National Fuel & Gas ............................              2.5
Nationsbank ....................................             16.0
Pep Boys (The) .................................             11.8
PepsiCo ........................................             11.1
Pfizer, Inc. ...................................             10.6
Phillip Morris .................................             21.2
PPG Industries .................................              3.4
Procter & Gamble ...............................             14.3
Providian ......................................             11.1
Questar ........................................              3.5
Reliastar Financial ............................             11.1
Rockwell International .........................              7.4
RPM, Inc. ......................................              7.1
Sara Lee .......................................             11.8
SBC Communications .............................              4.4
Sigma Aldrich ..................................             22.2
Sonoco Products ................................             12.5
Sysco ..........................................             18.2
Union Electric .................................              2.5
W.W. Grainger ..................................             15.0
Wal-Mart .......................................             17.6
Wisconsin Energy Corp. .........................              4.3
Worthington Ind ................................             10.0
                                                            -----
The average dividend increase for this group was            11.84%
                                                            =====

                                       63


<PAGE>



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or accompanied by the current prospectus, which details charges, investment 
objectives and operating policies.


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