HANCOCK JOHN INSTITUTIONAL SERIES TRUST
497, 1998-02-02
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                       JOHN HANCOCK INSTITUTIONAL SERIES TRUST
                  Supplements to Prospectus dated July 1, 1997


                          John Hancock Active Bond Fund

Currently,  the Fund has a policy allowing 25% of total assets to be invested in
junk bonds but also has a policy  requiring  75% of the fund's  debt  securities
(other than commercial paper) to consist of investment grade debt securities and
their  unrated  equivalent.  These two policies  imperfectly  overlap  therefore
creating a conflicting measure of debt ratings.  The change set forth below will
eliminate this conflict.

Replace the second sentence of the second  paragraph on page 8 of the Prospectus
with the following:

At least 75% of the Fund's total assets will  consist of  investment  grade debt
securities  (i.e.  within the four highest  grades as  determined  by Standard &
Poor's  Ratings  Group  ("S&P"),  AAA,  AA, A or BBB,  or by  Moody's  Investors
Service, Inc. ("Moody's"),  Aaa, Aa, A or Baa); or debt securities of banks, the
U.S. Government,  its agencies or instrumentalities  and other issuers not rated
as a matter of policy  by S&P or  Moody's  that are the  unrated  equivalent  of
investment grade; or cash and cash-equivalents.

                       John Hancock Fundamental Value Fund

On December 3, 1997,  the Trustees of John Hancock  Fundamental  Value Fund (the
"Fund")  voted to change the Fund's name to John  Hancock  Small  Capitalization
Value Fund effective  January 1, 1998. This change more accurately  reflects the
Fund's  investment  strategy.  To add further clarity,  the investment policy is
amended  to  reflect  a  high  level  of   investment  in  securities  of  small
capitalization issuers.

Replace  the  first  three  paragraphs  on page 11 of the  Prospectus  with  the
following:

Under  normal  circumstances,  the Fund  will  invest  at least 80% of its total
assets in common  stocks  and other  equity  securities,  including  convertible
securities,  preferred  stocks and warrants,  of domestic and foreign issuers of
small-sized  companies with a total market  capitalization of $1 billion or less
("small  capitalization  companies").  Higher  risks are often  associated  with
investments  in  companies  with  small  market  capitalizations.  See  "Smaller
Capitalization Companies."

The Fund's  investment  policy  reflects  the  Adviser's  belief  that while the
securities markets tend to be efficient, sufficiently persistent price anomalies
exist which the disciplined active equity manager seeks to exploit to achieve an
above-average rate of return.

                  John Hancock Small Capitalization Equity Fund

On December 3, 1997,  the Trustees of John Hancock Small  Capitalization  Equity
Fund  (the  "Fund")  voted to  change  the  Fund's  name to John  Hancock  Small
Capitalization Growth Fund effective January 1, 1998. The change more accurately
reflects  the Fund's  strategy  to invest in common  stocks of  rapidly  growing
smaller capitalization  companies offering above average growth potential.  This
strategy has been in place since inception.

                      John Hancock Multi-Sector Growth Fund

The discussion of who is responsible  for the day-to-day  management of the Fund
contained in the  "Organization  and Management of the Fund" section is replaced
with the following:

Barbara C. Friedman,  CFA, is leader of the fund's portfolio  management team. A
senior vice  president  of the  Adviser,  Ms.  Friedman has been a member of the
management  team since joining John Hancock Funds in January 1998. Ms.  Friedman
has been in the investment business since 1973.

January 26, 1998

<PAGE>
                     JOHN HANCOCK INSTITUTIONAL SERIES TRUST
                  Supplements to Prospectus dated July 1, 1997


                      John Hancock Dividend Performers Fund

The Dividend  Performers  Fund's (the "Fund") strategy seeks to invest in common
stocks  with a  record  of  having  increased  their  dividends  in  each of the
preceding ten or more years.  Therefore,  The Fund's investment policy regarding
fixed income and below  investment  grade  securities is being  eliminated.  The
Fund's  strategy as well as its team leader,  John F. Snyder,  III, have been in
place since the Fund's inception.

In order to accomplish this change the Prospectus should be modified as follows:

Delete the second paragraph on page 12 and replace with the following:

Under normal circumstances, the Fund invests at least 65% of its total assets in
dividend  paying  securities.  The  Adviser  expects  that  common  stocks  will
ordinarily  offer the greatest  dividend paying  potential and will constitute a
majority of the Fund's assets.  For defensive  purposes,  however,  the Fund may
temporarily  hold high grade  short-term  debt  securities.  The Adviser and the
Fund's  subadviser,  Sovereign Asset Management Corp.  ("SAMCorp"),  will select
securities for the Fund's portfolio mainly for their investment  character based
upon  generally  accepted  elements  of  intrinsic  value,   including  industry
position,  management,  financial  strength,  earnings power,  marketability and
prospects for future growth.

Delete the fourth paragraph on page 12 of the Prospectus.

The paragraph under the following heading in the "Organization and Management of
the Funds" section on page 23 of the prospectus is replaced as follows:

Dividend Performers Fund

John F. Snyder, III, assisted by a group of portfolio managers and analysts, has
been primarily  responsible for management of the Fund since its inception.  Mr.
Snyder is an executive vice president of the Adviser, has been in the investment
business since 1972 and has been associated with the Adviser since 1991.

Delete all references to Dividend Performers Fund under the heading "Lower Rated
Securities" on page 30 of the Prospectus.

November 17, 1997


                          John Hancock Global Bond Fund

Replace the second sentence of the fourth  paragraph on page 9 of the Prospectus
with the following:

The Fund may, however,  invest less than 35% of its total assets in fixed-income
debt securities rated, at the time of investment, as low as CCC by S&P or Caa by
Moody's  or their  respective  equivalent  ratings  and  unrated  securities  of
comparable credit quality.


September 10, 1997

KBOPS2  1/98






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